(Publication Only) Corynebacterium Spp. and Arcanobacterium Haemolyticum Identification

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R2737 Abstract (publication only) Corynebacterium spp. and Arcanobacterium haemolyticum identification. Usefulness of the Vitek 2 ANC card R. Soloaga*, N. Carrion, C. Barberis, M. Almuzara, L. Guelfand, J. Pidone, C. Vay (Buenos Aires, AR) Introduction: Corynebacterium diphtheriae and C.ulcerans may be isolated from suspected cases of classical diphtheria, cutaneous diphtheria and very rarely from other clinical infections. Non-diphtheric corynebacteria are opportunistic pathogens, especially in nosocomial setting where they have been associated with endocarditis, pulmonary infection, medical devices infections and urinary tract infection. A. haemolyticum infection manifests as exudative pharyngitis and tonsillitis accompanied by cervical lymphadenopathy and less commonly, the organism causes deep-seated infections and skin and soft-tissue infections Objective: The aim of this study was to determine the Vitek 2 ANC card (bioMèrieux, Marcy l’Etoile, France) performance for identification of the most frequently clinical relevant Corynebacterium species and Arcanobacterium haemolyticum Methods: Sixty-two unique clinical isolates (2 C. diphtheriae, 7 C. jeikeium, 10 C. amycolatum, 15 C.striatum, 12 C.urealyticum, 1 C.minutissimum, 8 C. pseudodiphtheriticum, 1 C. ulcerans and 6 Arcanobacterium haemolyticum) represented the 9 taxa included in the Vitek 2 ANC database and 6 strains represented related species not included in the database were analyzed in this study. All the strains were identified using 16S rRNA gene sequencing (16S) as the reference method. For Vitek identification, all the strains were isolated in pure culture on Columbia blood agar. After 24-48 h incubation to 35ºC in ambient air, a bacterial suspension was made in 0.45% aqueous ClNa and adjusted to a McFarland of 2.7-3.2 with Vitekk 2 Densicheck instrument (bioMérieux).The inoculated card was loaded into the Vitek 2C automated identification system according to the manufacturer´s instruction. A computer-assisted algorithm was used to interpret the results. Results: The Vitek 2C ANC card correctly identified 60 (96.7%) of 62 isolates; only two strain (2.3%) remained unidentified. The results were available within 6.25 h. Identification of 6 non-data base strains resulted in 3 strains incorrectly identified as belonging to species in the data base. Conclusion: ANC card could be considered a reliable and useful tool for routine use in the rapid identification of the most frequent Corynebacterium species isolated in human infections..

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ID 2 | Issue No: 4.1 | Issue Date: 29.10.14 | Page: 1 of 24 © Crown Copyright 2014 Identification of Corynebacterium Species
UK Standards for Microbiology Investigations Identification of Corynebacterium species Issued by the Standards Unit, Microbiology Services, PHE Bacteriology – Identification | ID 2 | Issue no: 4.1 | Issue date: 29.10.14 | Page: 1 of 24 © Crown copyright 2014 Identification of Corynebacterium species Acknowledgments UK Standards for Microbiology Investigations (SMIs) are developed under the auspices of Public Health England (PHE) working in partnership with the National Health Service (NHS), Public Health Wales and with the professional organisations whose logos are displayed below and listed on the website https://www.gov.uk/uk- standards-for-microbiology-investigations-smi-quality-and-consistency-in-clinical- laboratories. SMIs are developed, reviewed and revised by various working groups which are overseen by a steering committee (see https://www.gov.uk/government/groups/standards-for-microbiology-investigations- steering-committee). The contributions of many individuals in clinical, specialist and reference laboratories who have provided information and comments during the development of this document are acknowledged. We are grateful to the Medical Editors for editing the medical content. For further information please contact us at: Standards Unit Microbiology Services Public Health England 61 Colindale Avenue London NW9 5EQ E-mail: [email protected] Website: https://www.gov.uk/uk-standards-for-microbiology-investigations-smi-quality- and-consistency-in-clinical-laboratories UK Standards for Microbiology Investigations are produced in association with: Logos correct at time of publishing. Bacteriology – Identification | ID 2 | Issue no: 4.1 | Issue date: 29.10.14 | Page: 2 of 24 UK Standards for Microbiology Investigations | Issued by the Standards Unit, Public Health England Identification of Corynebacterium species Contents ACKNOWLEDGMENTS .........................................................................................................
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P.O. Box 131375, Bryanston, 2074 Ground Floor, Block 5 Bryanston Gate, 170 Curzon Road Bryanston, Johannesburg, South Africa www.thistle.co.za Tel: +27 (011) 463 3260 Fax: +27 (011) 463 3036 Fax to Email: + 27 (0) 86-557-2232 e-mail : [email protected] Please read this section first The HPCSA and the Med Tech Society have confirmed that this clinical case study, plus your routine review of your EQA reports from Thistle QA, should be documented as a “Journal Club” activity. This means that you must record those attending for CEU purposes. Thistle will not issue a certificate to cover these activities, nor send out “correct” answers to the CEU questions at the end of this case study. The Thistle QA CEU No is: MT-2015/009. Each attendee should claim THREE CEU points for completing this Quality Control Journal Club exercise, and retain a copy of the relevant Thistle QA Participation Certificate as proof of registration on a Thistle QA EQA. MICROBIOLOGY LEGEND CYCLE 38 ORGANISM 1 Arcanobacterium haemolyticum Arcanobacterium haemolyticum was first described by MacLean et al. in 1946 as a pathogen in cases of exudative pharyngitis and soft-tissue infections. In 1982 the previously named Corynebacterium haemolyticum was included in a new genus to reflect major differences in cell wall components and chemotaxonomic characters, the genus Arcanobacterium. Currently, there are nine identified species within this genus of which A. haemolyticum, A. pyogenes and A. bernardiae have been recovered from clinical specimens. It is a catalase-negative, aerobic, beta-haemolytic, nonmotile, irregular gram-positive to gram-variable rod that may be misidentified as Streptococcus species, Corynebacterium species, or A.
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