Supplementary information
Algorithms
1. Specific COPD code and more than one prescription of a COPD medication and presence of spirometry. The first COPD medication had to be prescribed within 4 weeks of the COPD diagnostic code. 2. Specific COPD code and presence of spirometry 3. Specific COPD code and more than one prescription of a COPD medication. The first COPD medication had to be prescribed within 4 weeks of the COPD diagnostic code. 4. Specific COPD code only 5. Non-specific bronchitis codes and more than one prescription of a COPD medication. The first COPD medication had to be prescribed within 4 weeks of the COPD diagnostic code. 6. Non-specific bronchitis codes only 7. Respiratory symptoms and presence of spirometry. Respiratory symptoms consisted of persistent cough, sputum production, or dyspnoea 8. Respiratory symptom definition only
Specific COPD codes medcode term 18476 COPD follow-up 45771 Chronic obstructive pulmonary disease does not disturb sleep 4084 Airways obstructn irreversible 794 Emphysema 998 Chronic obstructive airways disease 1001 Chronic obstructive pulmonary disease 5710 Chronic obstructive airways disease NOS 9520 Chronic obstructive pulmonary disease monitoring 9876 Severe chronic obstructive pulmonary disease 10802 Moderate chronic obstructive pulmonary disease 10863 Mild chronic obstructive pulmonary disease 10980 Centrilobular emphysema 11287 Chronic obstructive pulmonary disease annual review 14798 Emphysematous bronchitis 18621 Chronic obstructive pulmonary disease follow-up 18792 Chronic obstructive pulmonary disease monitoring admin 23492 Chronic bullous emphysema NOS 26018 Chronic obstructive pulmonary disease monitoring by nurse 26306 Chronic bullous emphysema 28755 Chronic obstructive pulmonary disease monitoring 1st letter 33450 Emphysema NOS 34202 Chronic obstructive pulmonary disease monitoring 2nd letter 34215 Chronic obstructive pulmonary disease monitoring 3rd letter 37247 Chronic obstructive pulmonary disease NOS 37371 Chronic obstructive pulmonary disease monitoring due 44525 Obstructive chronic bronchitis NOS 45998 Chronic obstructive pulmonary disease monitoring by doctor 93568 Very severe chronic obstructive pulmonary disease 12166 Other specified chronic obstructive airways disease 38074 Chronic obstructive pulmonary disease monitor phone invite 42258 Chronic obstructive pulmonary disease monitoring verb invite 42313 Health education - chronic obstructive pulmonary disease 45770 Chronic obstructive pulmonary disease disturbs sleep 45777 Chronic obstructive pulmonary disease clini management plan
COPD medication codes prodcode productname 8 salbutamol 100micrograms/dose inhaler 17 salbutamol 100micrograms/dose inhaler cfc free 31 ventolin 100microgram/inhalation inhalation powder (glaxo wellcome uk ltd) 38 beclometasone 100micrograms/dose inhaler 99 becotide 100 inhaler (glaxosmithkline uk ltd) 218 aminophylline 100 mg cap 235 bricanyl 250micrograms/dose inhaler (astrazeneca uk ltd) 273 theophylline 200 mg cap 282 salbutamol 2mg/5ml oral solution sugar free 454 pulmicort 200microgram inhaler (astrazeneca uk ltd) 465 salmeterol 25micrograms/dose inhaler 510 ventolin 5mg/ml respirator solution (glaxosmithkline uk ltd) 549 serevent 25micrograms/dose inhaler (glaxosmithkline uk ltd) 555 aminophylline 225mg modified-release tablets 590 phyllocontin continus 225mg tablets (napp pharmaceuticals ltd) 638 seretide 250 accuhaler (glaxosmithkline uk ltd) 665 seretide 100 accuhaler (glaxosmithkline uk ltd) 674 ventolin 2.5mg nebules (glaxosmithkline uk ltd) 696 salbutamol 8mg modified-release capsules 719 salmeterol 50micrograms/dose dry powder inhaler 746 tiotropium 18 microgram capsule 752 carbocisteine 375mg capsules 856 ventolin 2mg/5ml syrup (glaxosmithkline uk ltd) 860 salbutamol 4mg tablets 862 salbulin inhalation powder (3m health care ltd) 863 slo-phyllin 125mg capsule (lipha pharmaceuticals ltd) 879 theophylline 125mg modified-release capsules 880 theophylline 60mg modified-release capsules 881 salbutamol 2mg tablets 882 salbutamol 200microgram inhalation powder capsules 883 becodisks 200microgram disc (allen & hanburys ltd) 895 beclazone 100 easi-breathe inhaler (teva uk ltd) 896 becotide easi-breathe 100microgram/actuation pressurised inhalation (allen & hanburys ltd) 898 ventolin evohaler 100 100microgram/inhalation pressurised inhalation (glaxo wellcome uk ltd) 907 bricanyl turbohaler 500 500microgram turbohaler (astrazeneca uk ltd) 908 pulmicort 400 turbohaler (astrazeneca uk ltd) 909 budesonide 200micrograms/dose inhaler 910 serevent diskhaler 50microgram inhalation powder (glaxo wellcome uk ltd) 911 flixotide accuhaler 250 250microgram/inhalation inhalation powder (allen & hanburys ltd) 947 budesonide 50micrograms/actuation refill canister 956 pulmicort 200 turbohaler (astrazeneca uk ltd) 957 salamol easi-breathe 100microgram/actuation pressurised inhalation (ivax pharmaceuticals uk ltd) 958 ventolin easi-breathe 100microgram/actuation pressurised inhalation (allen & hanburys ltd) 959 budesonide 50micrograms/dose inhaler 960 pulmicort 100 turbohaler (astrazeneca uk ltd) 987 ventolin 4mg tablet (allen & hanburys ltd) 1093 salamol 100microgram/actuation inhalation powder (ivax pharmaceuticals uk ltd) 1097 slo-phyllin 60mg capsule (lipha pharmaceuticals ltd) 1100 beclazone 100 inhaler (teva uk ltd) 1236 becloforte 250micrograms/dose inhaler (glaxosmithkline uk ltd) 1242 beclometasone 250micrograms/dose inhaler 1243 beclazone 250 easi-breathe inhaler (teva uk ltd) 1258 becotide 200 inhaler (glaxosmithkline uk ltd) 1259 beclometasone 200micrograms/dose inhaler 1269 becotide 50microgram/ml nebuliser liquid (allen & hanburys ltd) 1346 salbutamol 0.05mg/ml injection 1406 becotide 50 inhaler (glaxosmithkline uk ltd) 1409 ipratropium bromide 20micrograms/dose inhaler 1410 ipratropium bromide 0.25mg/ml 1411 ipratropium bromide 250micrograms/ml 1412 flixotide 250microgram/actuation inhalation powder (allen & hanburys ltd) 1414 salamol 5mg/2.5ml nebuliser liquid steri-neb unit dose vials (teva uk ltd) 1415 steri-neb ipratropium 250microgram/ml nebuliser liquid (ivax pharmaceuticals uk ltd) 1423 uniphyllin continus 200mg tablets (napp pharmaceuticals ltd) 1424 flixotide 250microgram disc (allen & hanburys ltd) 1426 flixotide 500microgram disc (allen & hanburys ltd) 1518 flixotide 50microgram/actuation inhalation powder (allen & hanburys ltd) 1537 becotide 200microgram rotacaps (glaxosmithkline uk ltd) 1551 beclazone 250 inhaler (teva uk ltd) 1552 becloforte easi-breathe 250microgram/actuation pressurised inhalation (allen & hanburys ltd) 1619 terbutaline 500micrograms/dose dry powder inhaler 1620 terbutaline 250micrograms/dose inhaler 1628 terbutaline 250micrograms/actuation refill canister 1630 salbutamol 2.5mg/2.5ml nebuliser liquid unit dose vials 1635 salbuvent 2mg/5ml oral solution (pharmacia ltd) 1642 budesonide 400micrograms/dose dry powder inhaler 1676 flixotide 125microgram/actuation inhalation powder (allen & hanburys ltd) 1680 pulmicort ls 50micrograms/dose inhaler (astrazeneca uk ltd) 1698 salbutamol 100micrograms/dose breath actuated inhaler 1711 salbutamol 5mg/2.5ml nebuliser liquid unit dose vials 1725 beclazone 50 easi-breathe inhaler (teva uk ltd) 1727 becotide easi-breathe 50microgram/actuation pressurised inhalation (allen & hanburys ltd) 1734 beclometasone 100micrograms/dose breath actuated inhaler 1741 salbutamol 100micrograms/dose breath actuated inhaler cfc free 1833 theophylline 200mg modified-release tablets 1834 theophylline 400mg modified-release tablets 1861 aerobec 100 autohaler (meda pharmaceuticals ltd) 1882 ventodisks 200microgram/blister disc (allen & hanburys ltd) 1885 beclazone 200 inhaler (teva uk ltd) 1950 ventodisks 400microgram/blister disc (allen & hanburys ltd) 1951 becodisks 400microgram disc (allen & hanburys ltd) 1952 ventolin 400microgram rotacaps (glaxosmithkline uk ltd) 1956 pulmicort 1mg respules (astrazeneca uk ltd) 1957 ventolin 5mg nebules (glaxosmithkline uk ltd) 1959 pulmicort 0.5mg respules (astrazeneca uk ltd) 1972 oxygen bp size af lightweight gas 1360 litres 1974 oxis 12 turbohaler (astrazeneca uk ltd) 1975 oxis 6 turbohaler (astrazeneca uk ltd) 2044 prednisone 2.5 mg tab 2092 budesonide 200micrograms/dose dry powder inhaler 2124 pulmicort refil 200 mcg inh 2125 pulmicort 200microgram refill canister (astrazeneca uk ltd) 2147 theophylline 250mg modified-release capsules 2148 beclometasone 400microgram disc 2149 steri-neb salamol 2.5 mg inh 2152 ipratropium bromide with salbutamol 20mcg + 100mcg 2159 aerobec 50 autohaler (meda pharmaceuticals ltd) 2160 beclometasone 50micrograms/dose breath actuated inhaler 2224 serevent 50micrograms/dose accuhaler (glaxosmithkline uk ltd) 2229 becodisks 100microgram disc (allen & hanburys ltd) 2282 fluticasone 500micrograms/dose dry powder inhaler 2335 qvar 100 inhaler (teva uk ltd) 2368 prednisolone 2.5mg tablet 2390 prednisolone e/c 1 mg tab 2395 salbutamol 2 mg/5ml syr 2437 oxitropium bromide 100micrograms/dose inhaler 2440 flixotide accuhaler 500 500microgram/inhalation inhalation powder (allen & hanburys ltd) 2510 oxygen bp gas 1280 litres 2600 beclometasone 250micrograms/dose breath actuated inhaler 2655 airomir 100micrograms/dose inhaler (teva uk ltd) 2723 fluticasone 25micrograms/dose inhaler 2757 slo-phyllin 250mg capsule (lipha pharmaceuticals ltd) 2758 bricanyl refill canister (astrazeneca uk ltd) 2799 prednisolone 10 mg tab 2850 salbutamol 400microgram inhalation powder capsules 2851 ventolin 200microgram rotacaps (glaxosmithkline uk ltd) 2869 salbutamol 8mg modified-release tablets 2892 becloforte 400microgram disks (glaxosmithkline uk ltd) 2893 beclometasone 200micrograms disc 2949 prednisone 5mg tablets 2951 fluticasone 250microgram/actuation pressurised inhalation 2978 salbutamol 200micrograms/dose dry powder inhaler 2992 beclazone 50 inhaler (teva uk ltd) 2995 nuelin sa 175mg tablets (meda pharmaceuticals ltd) 3018 beclometasone 50micrograms/dose inhaler 3059 prednisolone 50 mg tab 3065 bextasol inhalation powder (allen & hanburys ltd) 3075 becotide 400microgram rotacaps (glaxosmithkline uk ltd) 3119 becloforte integra 250microgram/actuation inhaler with compact spacer (glaxo laboratories ltd) 3150 beclometasone 100micrograms/actuation extrafine particle cfc free inhaler 3163 salbutamol 200micrograms disc 3188 pulmicort complete 50 mcg inh 3189 salbuvent inh inh 3220 qvar 50 autohaler (teva uk ltd) 3254 salbulin 4mg tablet (3m health care ltd) 3289 flixotide 25micrograms/dose inhaler (glaxosmithkline uk ltd) 3297 salmeterol 50micrograms disc 3322 aerolin inh 400 100 mcg aer 3345 sintisone tablet (pharmacia ltd) 3347 oxygen bp size f gas 1360 litres 3363 becloforte 400microgram disks with diskhaler (glaxosmithkline uk ltd) 3388 theophylline 175mg modified-release tablets 3442 pulmicort complete 200 mcg inh 3443 salbutamol 100microgram/inhalation spacehaler (celltech pharma europe ltd) 3534 bricanyl 5mg tablets (astrazeneca uk ltd) 3546 qvar 50 inhaler (teva uk ltd) 3556 beclometasone 50micrograms with salbutamol 100micrograms/inhalation inhaler 3557 prednisone 1mg tablets 3570 budesonide 200micrograms/actuation refill canister 3584 bricanyl 1.5mg/5ml syrup (astrazeneca uk ltd) 3666 seretide 500 accuhaler (glaxosmithkline uk ltd) 3743 filair 50 inhaler (meda pharmaceuticals ltd) 3753 flixotide diskhaler-community pack 250 mcg 3758 pulmadil inhalation powder (3m health care ltd) 3763 terbutaline respules inh 3764 bricanyl respules (5mg/2ml) 2.5 mg/ml inh 3786 fenoterol 100micrograms/dose / ipratropium 40micrograms/dose inhaler 3838 salbutamol 400mcg/beclometh.100mcg r/cap inh 3927 filair 100 inhaler (meda pharmaceuticals ltd) 3947 becotide 100microgram rotacaps (glaxosmithkline uk ltd) 3988 flixotide diskhaler-community pack 100 mcg 3989 flixotide 100microgram disc (allen & hanburys ltd) 3993 filair forte 250micrograms/dose inhaler (meda pharmaceuticals ltd) 3994 salbutamol 4mg modified-release tablets 4055 salbulin 2mg/5ml oral solution (3m health care ltd) 4131 fluticasone 100microgram disc 4132 fluticasone 125microgram/actuation pressurised inhalation 4165 zithromax 250mg capsules (pfizer ltd) 4171 ventolin 2mg tablet (allen & hanburys ltd) 4222 bricanyl 10mg/ml respirator solution (astrazeneca uk ltd) 4268 ipratropium bromide 40micrograms/dose inhaler 4365 beclometasone 100micrograms disc 4412 oxygen bp size g gas 3400 litres 4413 qvar 100 autohaler (teva uk ltd) 4497 ventolin accuhaler 200 200microgram/actuation inhalation powder (glaxo wellcome uk ltd) 4499 aerobec 250microgram/actuation pressurised inhalation (meda pharmaceuticals ltd) 4514 aminophylline 350mg modified-release tablets 4538 oxygen bp size pd gas 300 litres 4541 bricanyl sa 7.5mg tablets (astrazeneca uk ltd) 4545 pulmicort ls 50microgram refill canister (astrazeneca uk ltd) 4593 theophylline 125mg tablets 4601 asmabec 100 clickhaler (focus pharmaceuticals ltd) 4634 salamol 2.5mg/2.5ml nebuliser liquid steri-neb unit dose vials (teva uk ltd) 4640 bricanyl 5mg/2ml nebuliser liquid (astrazeneca uk ltd) 4665 salbulin 100micrograms/dose inhaler (3m health care ltd) 4688 fluticasone 50microgram/actuation pressurised inhalation 4759 beclometasone 100microgram inhalation powder capsules 4791 oxygen bp size c gas 170 litres 4801 budesonide 500micrograms/2ml nebuliser liquid unit dose vials 4803 beclazone 250microgram/actuation inhalation powder (actavis uk ltd) 4842 fenoterol 100microgram/actuation inhaler 4908 ventolin rotahaler (glaxosmithkline uk ltd) 4926 flixotide accuhaler 100 100microgram/inhalation inhalation powder (allen & hanburys ltd) 4942 budesonide 1mg/2ml nebuliser liquid unit dose vials 5057 azithromycin 200mg/5ml oral suspension 5116 azithromycin 250mg capsules 5143 seretide 50 evohaler (glaxosmithkline uk ltd) 5161 seretide 125 evohaler (glaxosmithkline uk ltd) 5170 salamol 100micrograms/dose inhaler cfc free (teva uk ltd) 5172 seretide 250 evohaler (glaxosmithkline uk ltd) 5185 fenoterol 200micrograms/dose inhaler 5223 fluticasone 50micrograms/dose inhaler cfc free 5261 nuelin sa 250 tablets (meda pharmaceuticals ltd) 5308 terbutaline 5mg/2ml nebuliser liquid unit dose vials 5309 flixotide 50micrograms/dose evohaler (glaxosmithkline uk ltd) 5335 zithromax 500mg tablets (pfizer ltd) 5453 uniphyllin continus 400mg tablets (napp pharmaceuticals ltd) 5516 salamol 100micrograms/dose easi-breathe inhaler (teva uk ltd) 5521 beclometasone 200micrograms/dose dry powder inhaler 5522 beclometasone 100micrograms/dose dry powder inhaler 5551 flixotide 0.5mg/2ml nebules (glaxosmithkline uk ltd) 5558 salmeterol 50micrograms with fluticasone 500micrograms cfc free inhaler 5580 flixotide accuhaler 50 50microgram/inhalation inhalation powder (allen & hanburys ltd) 5584 oxygen cylinders size pd (boc ltd) 5683 flixotide 250micrograms/dose evohaler (glaxosmithkline uk ltd) 5718 flixotide 125micrograms/dose evohaler (glaxosmithkline uk ltd) 5740 airomir 100micrograms/dose autohaler (teva uk ltd) 5753 salbutamol 400micrograms disc 5773 oxygen bp size dd gas 460 litres 5780 oxygen cylinders size af (boc ltd) 5804 beclometasone 250micrograms/dose dry powder inhaler 5822 fluticasone 250micrograms/dose inhaler cfc free 5837 salamol steri-neb 5mg/2.5ml nebuliser liquid (numark management ltd) 5864 salmeterol 25micrograms with fluticasone 250micrograms cfc free inhaler 5885 fluticasone 100micrograms/dose dry powder inhaler 5889 salamol 100microgram/inhalation inhalation powder (kent pharmaceuticals ltd) 5898 salamol steri-neb 2.5mg/2.5ml nebuliser liquid (numark management ltd) 5941 uniphyllin continus 300mg tablets (napp pharmaceuticals ltd) 5942 salmeterol 50micrograms with fluticasone 250micrograms cfc free inhaler 5975 fluticasone 125micrograms/dose inhaler cfc free 5976 oxygen bp size dd 460 litre inhalation gas (boc ltd) 5992 beclometasone 50micrograms/dose dry powder inhaler 6081 ipratropium bromide 20micrograms/dose breath actuated inhaler 6276 carbocisteine 250mg/5ml oral solution 6315 slo-phyllin 250mg capsules (merck serono ltd) 6325 symbicort 200/6 turbohaler (astrazeneca uk ltd) 6419 oxygen cylinders size f (boc ltd) 6420 oxygen bp size d gas 340 litres 6423 oxygen bp with integral headset 1360 litre inhalation gas (boc ltd) 6462 salbutamol 95micrograms/dose dry powder inhaler 6522 ipratropium bromide 20micrograms/dose inhaler cfc free 6526 formoterol 12microgram inhalation powder capsules with device 6556 oxygen cylinders size c (boc ltd) 6569 salmeterol 25micrograms with fluticasone 125micrograms cfc free inhaler 6616 salmeterol 25micrograms with fluticasone 50micrograms cfc free inhaler 6619 oxygen bp size cd gas 460 litres 6719 ipratropium bromide 500micrograms/2ml nebuliser liquid unit dose vials 6746 budesonide 400micrograms/dose / formoterol 12micrograms/dose dry powder inhaler 6758 ipratropium 250micrograms/1ml nebuliser liquid steri-neb unit dose vials (teva uk ltd) 6768 oxygen bp size cd 460 litre inhalation gas (boc ltd) 6772 ipratropium bromide 250micrograms/1ml nebuliser liquid unit dose vials 6780 symbicort 400/12 turbohaler (astrazeneca uk ltd) 6796 budesonide 200micrograms/dose / formoterol 6micrograms/dose dry powder inhaler 6802 mucodyne 375mg capsules (sanofi) 6848 oxygen cylinders size dd with integral headset 2 and 4litres/minute flow rate (boc ltd) 6920 mecysteine 100mg gastro-resistant tablets 6938 salmeterol 50micrograms with fluticasone 100micrograms dry powder inhaler 6976 oxygen bp with integral headset gas 430 litres 6988 aminophylline hydrate 100mg modified-release tablets 7013 symbicort 100/6 turbohaler (astrazeneca uk ltd) 7017 salbutamol 100micrograms/dose dry powder inhaler 7031 oxygen bp size e gas 680 litres 7042 oxygen cylinders size e (boc ltd) 7133 formoterol 12micrograms/dose dry powder inhaler 7192 bambuterol 10mg tablets 7239 oxygen cylinders size b10s (air products plc) 7268 serevent 25micrograms/dose evohaler (glaxosmithkline uk ltd) 7270 salmeterol 25micrograms/dose inhaler cfc free 7452 ventolin .25 mg inj 7584 prednisolone 4 mg tab 7602 fluticasone 50microgram disc 7638 fluticasone 250microgram disc 7653 beclometasone 400microgram inhalation powder capsules 7710 prednisolone 15 mg tab 7711 terbutaline 250micrograms/dose inhaler with spacer 7724 betamethasone valerate 100micrograms/actuation inhaler 7730 theo-dur 300mg tablets (astrazeneca uk ltd) 7731 theo-dur 200mg tablets (astrazeneca uk ltd) 7732 theophylline 300mg modified-release tablets 7733 theophylline 250mg modified-release tablets 7788 budesonide 100micrograms/dose dry powder inhaler 7832 choline theophyllinate 200mg tablets 7841 nuelin 125mg tablets (3m health care ltd) 7891 fluticasone 500microgram disc 7934 prednisone 30 mg tab 7935 maxivent 100microgram/inhalation inhalation powder (ashbourne pharmaceuticals ltd) 7948 fluticasone 250micrograms/dose dry powder inhaler 7953 terbutaline 1.5mg/5ml oral solution sugar free 7954 bricanyl 250micrograms/dose spacer inhaler (astrazeneca uk ltd) 7964 beclometasone 50micrograms/ml nebuliser suspension 7965 salbutamol 5mg/ml nebuliser liquid 8012 exirel 15mg capsule (3m health care ltd) 8056 aminophylline 100mg tablets 8057 aminophylline 100mg modified-release tablets 8111 becloforte vm 250microgram/actuation vm pack (allen & hanburys ltd) 8183 oxygen bp gas 640 litres 8251 pulmicort refil 50 mg inh 8252 pirbuterol 15mg capsule 8267 sodium cromoglicate 1mg/dose / salbutamol 100micrograms/dose inhaler 8333 ipratropium bromide 40microgram inhalation powder capsules 8339 fenoterol hydrobromide complete unit inh 8429 ventolin i/v 5 mg inj 8433 budesonide 100micrograms/actuation inhaler 8450 flixotide diskhaler-community pack 50 mcg 8504 exirel 15 mg tab 8505 oxygen bp gas 6400 litres 8522 terbutaline 7.5mg modified-release tablets 8572 rimiterol inhaler 8635 flixotide 50microgram disc (allen & hanburys ltd) 8636 ventolin s/r 8 mg spa 8676 terbutaline 10mg/ml nebuliser liquid 8757 oxygen bp gas 3200 litres 8806 phyllocontin continus 350mg tablet (napp pharmaceuticals ltd) 8955 theophylline 100 mg tab 9018 mucodyne 375mg capsule (aventis pharma) 9092 theophylline 350mg modified release tablets 9164 fluticasone 50micrograms/dose dry powder inhaler 9233 beclometasone 200microgram inhalation powder capsules 9270 ipratropium bromide with fenoterol hydrobromide 500micrograms + 1.25mg/4ml 9384 salbutamol 4mg modified-release capsules 9477 asmabec 100microgram/actuation spacehaler (celltech pharma europe ltd) 9571 beclometasone 250micrograms/actuation vortex inhaler 9577 asmabec 50 clickhaler (focus pharmaceuticals ltd) 9599 beclazone 50microgram/actuation inhalation powder (actavis uk ltd) 9642 mucodyne 250mg/5ml oral solution (aventis pharma) 9651 asmasal 100microgram/inhalation spacehaler (celltech pharma europe ltd) 9658 oxitropium bromide 100micrograms/dose breath actuated inhaler 9711 formoterol 6micrograms/dose dry powder inhaler 9727 prednisolone 50mg tablets 9805 salbutamol 5mg/50ml solution for infusion vials 9889 oxygen cylinders size g (boc ltd) 9895 oxygen bp size df with integral headset gas 1360 litres 9906 mucodyne 250mg/5ml syrup (sanofi) 9921 beclometasone 100micrograms/dose breath actuated inhaler cfc free 9943 visclair 100mg gastro-resistant tablets (ranbaxy (uk) ltd) 10043 oxygen composite cylinders size b10c with integral headset (air products plc) 10053 oxygen connection cubing 1.8m 10090 beclometasone 50micrograms/actuation extrafine particle cfc free inhaler 10218 budesonide 100micrograms/dose / formoterol 6micrograms/dose dry powder inhaler 10321 budesonide 400microgram inhalation powder capsules 10331 nuelin 60mg/5ml liquid (3m health care ltd) 10353 salbuvent rondo 10360 aerocrom inhaler (castlemead healthcare ltd) 10407 phyllocontin paediatric continus 100mg tablets (napp pharmaceuticals ltd) 10433 theophylline 60mg/5ml oral solution 10458 ventolin cr 4mg tablet (allen & hanburys ltd) 10561 aminophylline 250mg/ml injection 10723 theophylline 125mg/5ml syrup 10744 theophylline 80 mg eli 10808 mucodyne paediatric 125mg/5ml syrup (sanofi) 10825 terbutaline 5mg tablets 10831 biophylline 125mg/5ml oral solution (lorex synthelabo ltd) 10858 pulmadil auto inhalation powder (3m health care ltd) 10958 salbutamol .25 mg inj 10968 foradil 12microgram inhalation powder capsules with device (novartis pharmaceuticals uk ltd) 11046 ipratropium bromide with salbutamol 500micrograms + 2.5mg/2.5ml 11149 betnelan 500microgram tablets (focus pharmaceuticals ltd) 11198 beclometasons 50 micrograms/actuation vortex inhaler 11307 salbutamol 100micrograms/dose / beclometasone 50micrograms/dose inhaler 11410 fluticasone 500micrograms/dose / salmeterol 50micrograms/dose dry powder inhaler 11478 fluticasone 2mg/2ml nebuliser liquid unit dose vials 11497 beclometasone 400micrograms/dose dry powder inhaler 11588 fluticasone 125micrograms/dose / salmeterol 25micrograms/dose inhaler cfc free 11618 fluticasone 250micrograms/dose / salmeterol 25micrograms/dose inhaler cfc free 11659 oxygen bp size dd with integral headset gas 460 litres 11719 slo-phyllin 60mg capsules (merck serono ltd) 11732 beclometasone 50micrograms/dose breath actuated inhaler cfc free 11779 ipratropium bromide 40microgram inhalation powder capsules with device 11993 pro-vent 300mg capsule (wellcome medical division) 12042 ventolin cr 8mg tablet (allen & hanburys ltd) 12144 bambuterol 20mg tablets 12240 theophylline 300mg modified release capsules 12463 pirbuterol 15 mg tab 12479 aerolin inh auto refil 100 mcg aer 12486 bronchodil 500microgram/dose inhalation powder (viatris pharmaceuticals ltd) 12529 fabrol 200mg granules (novartis consumer health uk ltd) 12563 exirel inhalation powder (3m health care ltd) 12699 pecram 225mg modified-release tablet (novartis consumer health uk ltd) 12808 fenoterol 100micrograms/dose / ipratropium bromide 40micrograms/dose breath actuated inhaler 12822 salbutamol 2.5mg with ipratropium bromide 500micrograms/2.5ml unit dose nebuilser solution 12909 salbutamol 100micrograms/dose / ipratropium 20micrograms/dose inhaler 12994 fluticasone 50micrograms/dose / salmeterol 25micrograms/dose inhaler cfc free 13037 pulvinal beclometasone dipropionate 200micrograms/dose dry powder inhaler (chiesi ltd) 13038 pulvinal salbutamol 200micrograms/dose dry powder inhaler (chiesi ltd) 13040 fluticasone 250micrograms/dose / salmeterol 50micrograms/dose dry powder inhaler 13181 easyhaler salbutamol sulphate 100micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 13206 oxygen bp with integral headset gas 300 litres 13273 fluticasone 100micrograms/dose / salmeterol 50micrograms/dose dry powder inhaler 13290 clenil modulite 100micrograms/dose inhaler (chiesi ltd) 13307 bricanyl 500microgram/ml injection (astrazeneca uk ltd) 13522 prednisolone 2 mg tab 13529 amnivent-225 sr tablets (ashbourne pharmaceuticals ltd) 13575 bambec 20mg tablets (astrazeneca uk ltd) 13615 prednisone 10 mg tab 13757 tropiovent steripoule 250microgram/ml nebuliser liquid (ashbourne pharmaceuticals ltd) 13815 beclazone 100microgram/actuation inhalation powder (actavis uk ltd) 13996 salamol 100microgram/inhalation inhalation powder (sandoz ltd) 14294 qvar 50micrograms/dose easi-breathe inhaler (teva uk ltd) 14306 formoterol 12micrograms/dose inhaler cfc free 14321 beclometasone 200micrograms/dose inhaler cfc free 14482 bricanyl 2.5 mg inj 14483 terbutaline 500micrograms/ml injection 14514 zithromax 200mg/5ml oral suspension (pfizer ltd) 14524 bdp 250microgram/actuation spacehaler (celltech pharma europe ltd) 14525 salbutamol 100micrograms/inhalation vortex inhaler 14527 bambec 10mg tablets (astrazeneca uk ltd) 14561 salbutamol 400microgram / beclometasone 200microgram inhalation powder capsules 14567 asmabec 250 clickhaler (focus pharmaceuticals ltd) 14590 asmabec 250microgram/actuation spacehaler (celltech pharma europe ltd) 14700 budesonide 400micrograms/actuation inhaler 14736 pulvinal beclometasone dipropionate 400micrograms/dose dry powder inhaler (chiesi ltd) 14739 norphyllin sr 225mg tablets (teva uk ltd) 14757 pulvinal beclometasone dipropionate 100micrograms/dose dry powder inhaler (chiesi ltd) 14991 aminophylline 250mg/10ml injection 15075 bronchodil 20mg tablet (viatris pharmaceuticals ltd) 15165 reproterol 500micrograms/dose inhaler 15214 oxygen bp size pd 300 litre inhalation gas (medigas ltd) 15281 oxygen cylinders size pa2 with integral headset (air products plc) 15284 slo-phyllin 125mg capsules (merck serono ltd) 15301 carbocisteine 125mg/5ml oral solution 15326 beclometasone 100micrograms/dose inhaler cfc free 15365 theophylline 10mg/5ml sf elixir 15409 theophylline 3 mg sol 15441 fenoterol hydrobromide .5 % sol 15613 salbutamol 500micrograms/1ml solution for injection ampoules 15706 beclometasone 100 micrograms/actuation vortex inhaler 15979 oxygen bp with integral headset 300 litre inhalation gas (boc ltd) 16054 budesonide 200micrograms/actuation breath actuated powder inhaler 16124 oxygen cylinders (medigas ltd) 16148 clenil modulite 250micrograms/dose inhaler (chiesi ltd) 16151 clenil modulite 200micrograms/dose inhaler (chiesi ltd) 16158 clenil modulite 50micrograms/dose inhaler (chiesi ltd) 16236 pirbuterol acetate inhaler 16305 flixotide 2mg/2ml nebules (glaxosmithkline uk ltd) 16523 oxygen cylinders size cd with integral headset 0-15litres/minute flow rate (boc ltd) 16577 easyhaler salbutamol sulphate 200micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 16584 beclometasone 50micrograms/dose inhaler cfc free 16625 ventide rotacaps (glaxosmithkline uk ltd) 16724 prednisone 50 mg tab 16994 aminophylline hydrate 350mg modified-release tablets 17002 aminophylline hydrate 225mg modified-release tablets 17005 oxygen bp size cd with integral headset gas 460 litres 17140 aminophylline 200mg tablets 17185 ventolin 500micrograms/1ml solution for injection ampoules (glaxosmithkline uk ltd) 17465 fluticasone 500micrograms/2ml nebuliser liquid unit dose vials 17644 oxygen bp with integral headset gas 2122 litres 17654 easyhaler beclometasone 200micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 17670 easyhaler budesonide 100micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 17696 ventmax sr 4mg capsules (chiesi ltd) 17874 monovent 1.5mg/5ml oral solution (lagap) 17901 bricanyl nebule 2.5 ml 18140 respontin 500micrograms/2ml nebules (glaxosmithkline uk ltd) 18288 choline theophyllinate 100mg tablets 18299 fenoterol 1.25mg/4ml / ipratropium 500micrograms/4ml nebuliser liquid unit dose vials 18314 aerocrom syncroner with spacer (castlemead healthcare ltd) 18394 bdp 50microgram/actuation spacehaler (celltech pharma europe ltd) 18421 respontin nebules 250microgram/ml nebuliser liquid (glaxo wellcome uk ltd) 18456 salbutamol 200microgram / beclometasone 100microgram inhalation powder capsules 18484 ventide paediatric rotacaps (glaxosmithkline uk ltd) 18537 budesonide 200microgram inhalation powder capsules 18622 salbulin 2mg tablet (3m health care ltd) 18848 qvar 100micrograms/dose easi-breathe inhaler (teva uk ltd) 18937 sabidal sr 270 270 mg tab 18968 salbutamol 5mg/5ml solution for infusion ampoules 18988 choline theophyllinate 62.5mg/5ml oral solution 19031 bdp 100microgram/actuation spacehaler (celltech pharma europe ltd) 19121 beclometasone 100micrograms with salbutamol 200micrograms inhalation capsules 19376 beclometasone 200micrograms with salbutamol 400micrograms inhalation capsules 19389 asmabec 50microgram/actuation spacehaler (celltech pharma europe ltd) 19401 beclometasone 250micrograms/actuation inhaler and compact spacer 19563 becotide for nebuliser 19642 ventolin nebules 19649 ventolin rotahaler 19653 ventolin respirator 19726 ventolin s/r 19732 cobutolin inh 19735 uniphyllin continus 19736 becotide susp for nebulisation 19737 atrovent nebuliser solution (1ml vial) 19799 tulobuterol 2mg 19805 atrovent 20095 precortisyl forte 25mg tablet (aventis pharma) 20225 aminophylline 500 mg inj 20670 prednisolone e/c 20675 salbutamol rotahaler complete unit 20680 aerolin autohaler 20707 becotide 100 20720 atrovent forte 20763 becloforte 20781 salbutamol u.dose nebulising 2.5mg/2.5ml 20803 ipratropium bromide nebuliser solution 20812 pulmicort refill 20825 spacehaler bdp 250microgram/actuation spacehaler (celltech pharma europe ltd) 20838 salbuvent 2mg tablet (pharmacia ltd) 21005 beclometasone 250micrograms/dose inhaler cfc free 21102 salbutamol 2mg/5ml oral solution (lagap) 21330 oxygen composite cylinders size if2 with integral headset (medigas ltd) 21331 oxygen composite cylinders with integral headset (air products plc) 21402 oxygen cylinders size pd (air products plc) 21482 beclometasone 100micrograms/dose inhaler (generics (uk) ltd) 21769 lasma 300mg tablet (pharmax ltd) 21833 decortisyl 5mg tablet (roussel laboratories ltd) 21859 asmaven 100microgram inhalation powder (berk pharmaceuticals ltd) 22080 aminophylline 20 ml inj 22225 beclomethasone /salbutamol 22313 ventmax sr 8mg capsules (chiesi ltd) 22430 spacehaler salbutamol 100microgram/inhalation spacehaler (celltech pharma europe ltd) 22467 salbutamol respirator soln 22512 salbutamol inhaler 22550 duovent 22661 pirbuterol 10mg capsule 22663 respacal 2mg tablet (ucb pharma ltd) 22669 choline theophyllinate 270 mg tab 22790 reproterol 10mg/ml respirator solution 22828 carbocisteine 750mg/5ml forte oral solution 23269 maxivent 2.5mg/2.5ml nebuliser liquid unit dose steripoule vials (ashbourne pharmaceuticals ltd) 23337 oxygen cylinder f size 1280 litres 23512 precortisyl 5mg tablet (hoechst marion roussel) 23567 respontin 250micrograms/1ml nebules (glaxosmithkline uk ltd) 23572 aminophylline sr 225mg modified-release tablet (ivax pharmaceuticals uk ltd) 23675 pulmicort l.s. refil 23688 ventolin rotacaps 23709 ipratropium 500micrograms/2ml nebuliser liquid steri-neb unit dose vials (teva uk ltd) 23741 novolizer budesonide 200microgram/actuation pressurised inhalation (meda pharmaceuticals ltd) 23787 exirel 10mg capsule (3m health care ltd) 23905 oxygen cylinders size d (boc ltd) 23961 ipratropium bromide 250microgram/ml inhalation vapour (galen ltd) 24219 becotide rotacaps 24380 sodium cromoglicate 1mg/dose / salbutamol 100micrograms/dose inhaler with spacer 24418 biophylline 350mg tablet (lorex synthelabo ltd) 24456 carbocisteine 375mg tablets 24645 ventolin 5mg/5ml solution for infusion ampoules (glaxosmithkline uk ltd) 24660 betamethasone valerate 24674 biophylline 500mg tablet (lorex synthelabo ltd) 24716 prednisolone e/c 24898 spacehaler bdp 100microgram/actuation spacehaler (celltech pharma europe ltd) 25020 ipratropium bromide (forte) 25073 salbutamol 25093 theophylline s/r 25204 beclometasone 100micrograms/dose inhaler (a a h pharmaceuticals ltd) 25218 salbutamol cfc/free b/a 25272 precortisyl 1mg tablet (hoechst marion roussel) 25339 maxivent 5mg/2.5ml nebuliser liquid unit dose steripoule vials (ashbourne pharmaceuticals ltd) 25784 atimos modulite 12micrograms/dose inhaler (chiesi ltd) 25820 bronchodil 10mg/5ml oral solution (viatris pharmaceuticals ltd) 25821 exirel 7.5mg/5ml oral solution (3m health care ltd) 25829 pirbuterol 7.5mg/5ml oral solution 26063 beclometasone 100micrograms/dose inhaler (teva uk ltd) 26079 uniphyllin paediatric continus 26420 exirel 10 mg tab 26525 ventolin 26616 ipratropium bromide with fenoterol hydrobromide 0micrograms + 100micrograms/actuation 26665 pulmicort complete 26716 airomir autohaler cfc free b/a 26829 brelomax 2mg tablet (abbott laboratories ltd) 26873 cobutolin 2mg tablet (actavis uk ltd) 27040 phyllocontin continus 27188 easyhaler budesonide 200micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 27301 bromhexine hcl 8mg tablets 27340 salbuvent 0.5mg/ml injection (pharmacia ltd) 27505 ipratropium bromide with fenoterol hydrobromide 40micrograms + 100micrograms/actuation 27525 becotide 50 27558 choledyl 27573 ventolin 27583 pulmicort 27679 beclometasone 100microgram/actuation pressurised inhalation (approved prescription services ltd) 27842 aminophylline 2 ml inj 27889 prednisolone 27915 fluticasone prop disk refill 27959 prednisolone 27962 deltastab 1mg tablet (waymade healthcare plc) 28073 beclometasone 250microgram/actuation pressurised inhalation (approved prescription services ltd) 28241 aminophylline 250mg/10ml solution for injection minijet pre-filled syringes (ucb pharma ltd) 28376 prednisolone 2.5mg gastro-resistant tablet (biorex laboratories ltd) 28508 salbutamol 100microgram/inhalation inhalation powder (ivax pharmaceuticals uk ltd) 28577 ventolin 50microgram/ml injection (allen & hanburys ltd) 28640 beclometasone 100microgram/actuation inhalation powder (actavis uk ltd) 28761 spacehaler bdp 50microgram/actuation spacehaler (celltech pharma europe ltd) 28859 deltastab 5mg tablet (waymade healthcare plc) 28881 salbutamol 2mg/5ml oral solution sugar free (a a h pharmaceuticals ltd) 29267 salbuvent 4mg tablet (pharmacia ltd) 29273 aminophylline 225mg modified-release tablet (hillcross pharmaceuticals ltd) 29325 beclometasone 250micrograms/dose inhaler (generics (uk) ltd) 30118 salbutamol 100micrograms/dose inhaler cfc free (teva uk ltd) 30204 salbutamol 200micrograms inahalation capsules 30210 beclometasone 250micrograms/dose inhaler (teva uk ltd) 30212 salbutamol cyclohaler 30229 ipratropium bromide 250microgram/ml nebuliser liquid (galen ltd) 30230 salbutamol 100micrograms/actuation breath actuated inhaler 30238 beclometasone 50microgram/actuation pressurised inhalation (approved prescription services ltd) 30240 aerolin autohaler 100microgram/actuation pressurised inhalation (3m health care ltd) 30390 deltastab 2 mg tab 30596 aminophylline 225mg modified-release tablet (actavis uk ltd) 30649 easyhaler budesonide 400micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 30971 decortisyl 25 mg tab 31082 salbuvent 5mg/ml respirator solution (pharmacia ltd) 31290 salbulin cfc free 31327 prednisolone steaglate 6.65mg tablet 31758 uniphyllin continus 31774 beclometasone 50micrograms/dose inhaler (generics (uk) ltd) 31845 salapin 2mg/5ml syrup (pinewood healthcare) 31933 salbutamol 100micrograms/dose inhaler (a a h pharmaceuticals ltd) 32050 salbutamol 400 cyclocaps (teva uk ltd) 32102 salbutamol 4mg tablets (a a h pharmaceuticals ltd) 32461 choline theophyllinate 90 mg tab 32812 numotac 10mg tablet (3m health care ltd) 32874 beclometasone 50microgram/actuation inhalation powder (actavis uk ltd) 32893 theophylline 100mg/lysine 74mg mg tab 33089 salbutamol 100micrograms/dose inhaler (kent pharmaceuticals ltd) 33258 beclometasone 250micrograms/dose inhaler (a a h pharmaceuticals ltd) 33373 salbutamol 200 cyclocaps (teva uk ltd) 33588 salbutamol 100micrograms/dose inhaler (generics (uk) ltd) 33691 prednisolone 5mg gastro-resistant tablet (biorex laboratories ltd) 33817 salbutamol 100micrograms/dose inhaler cfc free (actavis uk ltd) 33849 beclometasone 100microgram/actuation inhalation powder (neo laboratories ltd) 33888 azithromycin 250mg tablets 33988 prednisolone 5mg tablet (co-pharma ltd) 33990 prednisolone 5mg tablet (ivax pharmaceuticals uk ltd) 34018 salbutamol 5mg/2.5ml nebuliser liquid (galen ltd) 34029 salbutamol 400micrograms inahalation capsules 34109 prednisolone 5 mg gastro-resistant tablet 34134 aerolin 400 100microgram/actuation inhalation powder (3m health care ltd) 34162 salbutamol 2.5mg/2.5ml nebuliser liquid (galen ltd) 34310 salbutamol 100micrograms/dose inhaler cfc free (a a h pharmaceuticals ltd) 34311 salbutamol 100microgram/inhalation inhalation powder (berk pharmaceuticals ltd) 34315 beclometasone 250microgram/actuation inhalation powder (actavis uk ltd) 34428 beclometasone 50microgram/actuation inhalation powder (neo laboratories ltd) 34618 salbutamol 2mg tablets (actavis uk ltd) 34619 salbutamol 100microgram/inhalation inhalation powder (kent pharmaceuticals ltd) 34631 prednisolone 1mg tablet (co-pharma ltd) 34702 salbutamol 100microgram/inhalation inhalation powder (c p pharmaceuticals ltd) 34739 beclometasone 50micrograms/dose inhaler (teva uk ltd) 34794 beclometasone 200micrograms/dose inhaler (a a h pharmaceuticals ltd) 34859 beclometasone 250microgram/actuation inhalation powder (neo laboratories ltd) 34914 prednisolone 1mg tablet (celltech pharma europe ltd) 34919 beclometasone 50micrograms/dose inhaler (a a h pharmaceuticals ltd) 34938 salbutamol 4mg tablets (actavis uk ltd) 35011 tiotropium bromide 18microgram inhalation powder capsules 35014 tiotropium bromide 18microgram inhalation powder capsules with device 35015 erdosteine 300mg capsules 35071 becodisks 200microgram (glaxosmithkline uk ltd) 35106 becodisks 100microgram with diskhaler (glaxosmithkline uk ltd) 35107 beclometasone 400microgram inhalation powder blisters with device 35113 beclometasone 200microgram inhalation powder blisters 35118 becodisks 400microgram with diskhaler (glaxosmithkline uk ltd) 35165 serevent 50microgram disks with diskhaler (glaxosmithkline uk ltd) 35178 erdotin 300mg capsules (galen ltd) 35225 flixotide 100microgram disks with diskhaler (glaxosmithkline uk ltd) 35288 beclometasone 400microgram inhalation powder blisters 35293 beclometasone 200microgram inhalation powder blisters with device 35299 becodisks 400microgram (glaxosmithkline uk ltd) 35374 flixotide 500microgram disks (glaxosmithkline uk ltd) 35392 flixotide 500microgram disks with diskhaler (glaxosmithkline uk ltd) 35408 becodisks 100microgram (glaxosmithkline uk ltd) 35430 becodisks 200microgram with diskhaler (glaxosmithkline uk ltd) 35461 flixotide 250microgram disks with diskhaler (glaxosmithkline uk ltd) 35503 salmeterol 50microgram inhalation powder blisters 35510 budesonide 200micrograms/dose dry powder inhalation cartridge with device 35522 bricanyl 500micrograms/1ml solution for injection ampoules (astrazeneca uk ltd) 35542 salmeterol 50microgram inhalation powder blisters with device 35557 ipramol nebuliser solution 2.5ml steri-neb unit dose vials (teva uk ltd) 35566 oxygen bp with set gas 1360 litres 35580 beclometasone 100microgram inhalation powder blisters with device 35602 budesonide 200micrograms/dose dry powder inhalation cartridge 35611 flixotide 250microgram disks (glaxosmithkline uk ltd) 35631 budelin novolizer 200micrograms/dose inhalation powder (meda pharmaceuticals ltd) 35638 fluticasone 100microgram inhalation powder blisters with device 35652 beclometasone 100microgram inhalation powder blisters 35700 fluticasone 500microgram inhalation powder blisters with device 35724 budelin novolizer 200micrograms/dose inhalation powder refill (meda pharmaceuticals ltd) 35725 formoterol easyhaler 12micrograms/dose dry powder inhaler (orion pharma (uk) ltd) 35744 bricanyl 2.5mg/5ml solution for injection ampoules (astrazeneca uk ltd) 35772 fluticasone 100microgram inhalation powder blisters 35825 serevent 50microgram disks (glaxosmithkline uk ltd) 35861 terbutaline 2.5mg/5ml solution for injection ampoules 35862 terbutaline 500micrograms/1ml solution for injection ampoules 35905 fluticasone 250microgram inhalation powder blisters 35986 flixotide 50microgram disks (glaxosmithkline uk ltd) 36021 fluticasone 50microgram inhalation powder blisters with device 36090 flixotide 100microgram disks (glaxosmithkline uk ltd) 36290 flixotide 50microgram disks with diskhaler (glaxosmithkline uk ltd) 36401 fluticasone 250microgram inhalation powder blisters with device 36462 fluticasone 500microgram inhalation powder blisters 36677 reproterol 10mg/5ml oral solution 36864 tiotropium bromide 2.5micrograms/dose solution for inhalation cartridge with device cfc free 37432 fostair 100micrograms/dose/6micrograms/dose inhaler (chiesi ltd) 37447 fluticasone 50microgram inhalation powder blisters 37470 beclometasone 100micrograms/dose / formoterol 6micrograms/dose inhaler cfc free 37612 terbutaline 5mg/2ml nebuliser liquid unit dose vials (galen ltd) 37791 ipratropium bromide 250microgram/ml 38079 salbutamol 100micrograms/dose dry powder inhalation cartridge with device 38097 salbutamol cyclocaps 200microgram inhalation powder (dupont pharmaceuticals ltd) 38120 theophylline 500mg modified release tablets 38136 salbulin novolizer 100micrograms/dose inhalation powder (meda pharmaceuticals ltd) 38214 salbutamol 100micrograms/dose dry powder inhalation cartridge 38226 salbulin novolizer 100micrograms/dose inhalation powder refill (meda pharmaceuticals ltd) 38407 prednisolone 20mg tablet 38416 salbutamol cyclocaps 400microgram inhalation powder (dupont pharmaceuticals ltd) 38419 terbutaline 1.5mg/5ml oral solution sugar free (a a h pharmaceuticals ltd) 39040 phyllocontin forte continus 350mg tablets (napp pharmaceuticals ltd) 39099 pulmicort 100micrograms/dose inhaler cfc free (astrazeneca uk ltd) 39102 budesonide 100micrograms/dose inhaler cfc free 39200 aerobec forte 250 autohaler (meda pharmaceuticals ltd) 39879 budesonide 200micrograms/dose inhaler cfc free 40057 pulmicort 200micrograms/dose inhaler cfc free (astrazeneca uk ltd) 40177 ipratropium bromide 250microgram/ml nebuliser liquid (hillcross pharmaceuticals ltd) 40218 azithromycin 500mg tablets (teva uk ltd) 40599 salbutamol 5mg/2.5ml nebuliser liquid unit dose steripoule vials (galen ltd) 40637 ipratropium 250micrograms/1ml nebuliser liquid unit dose steripoule vials (galen ltd) 40655 salbuvent 100microgram/actuation inhalation powder (pharmacia ltd) 40709 salbutamol 2.5mg/2.5ml nebuliser liquid unit dose vials (a a h pharmaceuticals ltd) 40832 ipratropium 500micrograms/2ml nebuliser liquid unit dose steripoule vials (galen ltd) 41269 beclometasone 400 cyclocaps (teva uk ltd) 41412 beclometasone 400micrograms/actuation inhaler 41548 salbutamol 2mg tablets (approved prescription services ltd) 41549 salbutamol 2mg tablet (c p pharmaceuticals ltd) 41691 salbutamol 2mg/5ml oral solution sugar free (sandoz ltd) 41832 monovent 1.5mg/5ml syrup (sandoz ltd) 42103 tulobuterol 1mg/5ml sugar free syrup 42279 salbutamol 2.5mg/2.5ml nebuliser liquid unit dose steripoule vials (galen ltd) 42497 salbutamol 8mg tablet 42511 aminophylline 25mg/ml injection (celltech pharma europe ltd) 42830 ventolin 100micrograms/dose evohaler (glaxosmithkline uk ltd) 42858 ventolin 200micrograms/dose accuhaler (glaxosmithkline uk ltd) 42867 terbutaline 1.5mg/5ml oral solution (sandoz ltd) 42886 bricanyl 500micrograms/dose turbohaler (astrazeneca uk ltd) 42910 aminophylline 250mg/10ml solution for injection ampoules (martindale pharmaceuticals ltd) 42928 flixotide 100micrograms/dose accuhaler (glaxosmithkline uk ltd) 42985 flixotide 50micrograms/dose accuhaler (glaxosmithkline uk ltd) 42994 flixotide 250micrograms/dose accuhaler (glaxosmithkline uk ltd) 43046 salipraneb 0.5mg/2.5mg nebuliser solution 2.5ml ampoules (arrow generics ltd) 43074 flixotide 500micrograms/dose accuhaler (glaxosmithkline uk ltd) 43085 bricanyl 5mg/2ml respules (astrazeneca uk ltd) 43400 clamelle 500mg tablets (actavis uk ltd) 43544 prednisone 5mg tablet (knoll ltd) 43738 indacaterol 150microgram inhalation powder capsules with device 43794 nebusal 7% inhalation solution 4ml ampoules (forest laboratories uk ltd) 43870 sodium chloride 7% inhalation solution 4ml ampoules 43893 onbrez breezhaler 150microgram inhalation powder capsules with device (novartis pharmaceuticals uk ltd) 44064 onbrez breezhaler 300microgram inhalation powder capsules with device (novartis pharmaceuticals uk ltd) 44173 roflumilast 500microgram tablets 44380 prednisone 1mg modified-release tablets 44431 daxas 500microgram tablets (takeda uk ltd) 44713 salbutamol 100microgram/inhalation inhalation powder (celltech pharma europe ltd) 45302 prednisolone 5mg tablet (biorex laboratories ltd) 45610 indacaterol 300microgram inhalation powder capsules with device 45863 salbutamol 5mg/2.5ml nebuliser liquid (generics (uk) ltd) 46157 beclometasone 200 cyclocaps (teva uk ltd) 46551 salbutamol 100microgram/inhalation inhalation powder (neo laboratories ltd) 46695 azithromycin 500mg tablet (hillcross pharmaceuticals ltd) 49016 sodium chloride 7% inhalation solution 4ml vials 49045 nebusal 7% inhalation solution 4ml vials (forest laboratories uk ltd) 49530 azithromycin 200mg/5ml oral suspension (sandoz ltd) 50508 mucodyne 250mg/5ml syrup (sigma pharmaceuticals plc) 52029 zithromax 250mg capsules (mawdsley-brooks & company ltd) 53303 carbocisteine 375mg capsules (arrow generics ltd)
Spirometry codes medcode readterm 6118 spirometry 10336 spirometry reversibility 10337 spirometry screening 10420 spirometry reversibility negative 10492 spirometry reversibility positive 13683 referral for spirometry 14453 forced expiratory volume - fev 19428 chronic obstructive pulmonary disease excluded by spirometry 26241 spirometry indicated 29015 spirometry 45993 incentive spirometry 102522 post bronchodilator spirometry 6091 Percent predicted FEV1 8512 FEV1/FVC percent 10320 Forced expired volume in 1 second 11078 FEV1/FVC > 70% of predicted 14455 FEV1/FVC ratio normal 14456 FEV1/FVC ratio 19830 FEV1 after bronchodilation 19832 FEV1/FVC ratio after bronchodilator 23237 FEV1 before bronchodilation 23285 FEV1/FVC ratio abnormal 25083 FEV1/FVC < 70% of predicted 27141 FEV1/FVC ratio before bronchodilator 43040 FEV1 pre steroids 43041 FEV1 post steroids 58632 FEV1/FVC ratio pre steroids 58633 FEV1/FVC ratio post steroids 99777 Forced expired volume in 1 second reversibility 100391 Forced expired volume in 1 second percentage change 101079 Percentage predicted FEV1 after bronchodilation
Non-specific bronchitis codes / Frequent winter bronchitis medcode readterm 148 bronchitis unspecified 152 wheezy bronchitis 3243 chronic bronchitis 3480 bronchitis nos 4519 h/o: bronchitis 5798 chronic asthmatic bronchitis 5909 chronic wheezy bronchitis 7092 recurrent wheezy bronchitis 11150 mucopurulent chronic bronchitis 13247 fh: bronchitis 13262 fh: bronchitis/coad 14798 emphysematous bronchitis 15157 chronic bronchitis nos 15626 chronic catarrhal bronchitis 17359 chest infection - unspecified bronchitis 24248 mixed simple and mucopurulent chronic bronchitis 25603 simple chronic bronchitis 27819 obstructive chronic bronchitis 37959 fetid chronic bronchitis 40159 purulent chronic bronchitis 44525 obstructive chronic bronchitis nos 61118 simple chronic bronchitis nos 61513 mucopurulent chronic bronchitis nos 62913 [v]screening for chronic bronchitis or emphysema 66043 other chronic bronchitis 68066 other chronic bronchitis nos 202167 INFLUENZAL BRONCHITIS 207165 Acute streptococcal bronchitis 207166 Acute viral bronchitis unspecified 216109 Acute membranous bronchitis 216111 Acute bronchitis due to mycoplasma pneumoniae 216112 Acute bronchitis NOS 216141 Chest infection - unspecified bronchopneumonia 220234 BRONCHITIS FIBRINOUS ACUTE 225216 Acute pseudomembranous bronchitis 225241 Bronchitis NOS 234340 Acute bronchitis due to rhinovirus 239395 H/O: bronchitis 243349 Acute bronchitis and bronchiolitis 243350 Acute pneumococcal bronchitis 243351 Acute bronchitis due to echovirus 243389 Bronchitis unspecified 261710 Acute wheezy bronchitis 261711 Acute purulent bronchitis 261712 Acute croupous bronchitis 261713 Acute bronchitis due to respiratory syncytial virus 271007 Acute bronchitis due to coxsackievirus 280054 Acute fibrinous bronchitis 280055 Acute bronchitis due to parainfluenza virus 280082 Chest infection - unspecified bronchitis 289164 Acute bronchitis 289165 Acute neisseria catarrhalis bronchitis 289166 Subacute bronchitis unspecified 289233 [X]Acute bronchitis due to other specified organisms 293231 BRONCHITIS SUBACUTE 298435 Acute haemophilus influenzae bronchitis 298436 Acute bacterial bronchitis unspecified 298440 Acute bronchitis or bronchiolitis NOS 303952 BRONCHITIS ACUTE 303954 VIRAL BRONCHITIS 303963 BRONCHOPNEUMONIA 306525 BRONCHITIS PURULENT 306528 CATARRHAL BRONCHITIS 308788 Acute bronchitis
Respiratory symptom codes
Wheeze medcode readterm 152 wheezy bronchitis 173 wheezing 2210 [d]wheezing 2891 wheezing symptom 4836 nocturnal cough / wheeze 5861 o/e - expiratory wheeze 5909 chronic wheezy bronchitis 5978 acute wheezy bronchitis 7092 recurrent wheezy bronchitis 42317 increasing exercise wheeze 100954 [d]mild wheeze 101037 [d]moderate wheeze 101073 [d]severe wheeze 101421 [d]very severe wheeze 102480 on examination - inspiratory wheeze
Chronic cough medcode readterm 92 cough 292 chesty cough 1025 bronchial cough 1160 [d]cough 1234 productive cough nos 1273 c/o - cough 1612 chronic cough 3068 night cough present 3628 persistent cough 3645 coughing up phlegm 4070 morning cough 4836 nocturnal cough / wheeze 4931 dry cough 7706 productive cough -clear sputum 7707 cough symptom nos 7708 productive cough-yellow sputum 7773 productive cough -green sputum 16717 smokers' cough 22318 difficulty in coughing up sputum 29318 evening cough 43795 unexplained cough 60903 cough aggravates symptom 100333 cough on exercise
Exertional breathlessness medcode readterm 735 [d]breathlessness 1429 breathlessness 3092 [d]dyspnoea 5175 breathlessness symptom 5896 dyspnoea - symptom 6326 breathless - moderate exertion 7000 o/e - dyspnoea 7932 breathless - mild exertion 19426 mrc breathlessness scale: grade 3 19427 mrc breathlessness scale: grade 2 19429 mrc breathlessness scale: grade 5 19430 mrc breathlessness scale: grade 4 19432 mrc breathlessness scale: grade 1 21801 breathlessness nos 24889 breathless - strenuous exertion 31143 breathless - at rest 42287 borg breathlessness score: 6 severe (+) 53771 dyspnoea on exertion 57193 borg breathlessness score: 3 moderate 57759 borg breathlessness score: 2 slight 59860 borg breathlessness score: 4 somewhat severe 64049 borg breathlessness score: 5 severe 67566 borg breathlessness score: 9 very, very sev (almost maximal) 68707 borg breathlessness score: 1 very slight 70061 borg breathlessness score: 7 very severe 70818 borg breathlessness score: 0.5 very, very slight 72334 borg breathlessness score: 8 very severe (+) 101843 borg breathlessness score: 10 maximal 741 [D]Shortness of breath 2563 [D]Respiratory distress 2575 Short of breath on exertion 2931 Difficulty breathing 4822 Shortness of breath 5349 Shortness of breath symptom 9297 [D]Respiratory insufficiency 22094 Short of breath dressing/undressing 40813 Unable to complete a sentence in one breath
Sputum codes medcode readterm 292 chesty cough 1025 bronchial cough 1234 productive cough nos 3645 coughing up phlegm 7706 productive cough -clear sputum 7708 productive cough-yellow sputum 7773 productive cough -green sputum 22318 difficulty in coughing up sputum 1251 [d]abnormal sputum 3727 sputum sent for c/s 8287 sputum sample obtained 8760 [d]positive culture findings in sputum 9807 sputum - symptom 14804 sputum appears infected 15430 [d]sputum abnormal - colour 16026 sputum examination: abnormal 18964 sputum clearance 20086 [d]sputum abnormal - amount 22318 difficulty in coughing up sputum 23582 [d]abnormal sputum nos 24181 sputum: mucopurulent 29294 sputum appears normal 30754 yellow sputum 30904 sputum sent for examination 31417 sputum - not infected 35577 sputum examination - general 36515 [d]abnormal sputum - tenacious 36880 green sputum 40201 sputum microscopy: nad 40202 mucoid sputum - o/e 42573 clear sputum 43270 sputum evidence of infection 43272 sputum examination nos 44214 [d]sputum abnormal - odour 49029 sputum gen. exam. nos 49694 sputum: organism on gram stain 52806 sputum: frothy/watery 54177 sputum: excessive - mucoid 61079 sputum inspection nos 91680 expectoration of induced sputum from respiratory tract 100484 volume of sputum 100524 moderate sputum 100629 white sputum 100647 copious sputum 100931 brown sputum 101782 profuse sputum 103209 grey sputum
QOF codes
H3... Chronic obstructive pulmonary disease H31.. Chronic bronchitis H310. Simple chronic bronchitis H3100 Chronic catarrhal bronchitis H310z Simple chronic bronchitis NOS H311. Mucopurulent chronic bronchitis H3110 Purulent chronic bronchitis H3111 Fetid chronic bronchitis H311z Mucopurulent chronic bronchitis NOS H312. Obstructive chronic bronchitis H3120 Chronic asthmatic bronchitis H3121 Emphysematous bronchitis H3123 Bronchiolitis obliterans H312z Obstructive chronic bronchitis NOS H313. Mixed simple and mucopurulent chronic bronchitis H31y. Other chronic bronchitis H31y1 Chronic tracheobronchitis H31yz Other chronic bronchitis NOS H31z. Chronic bronchitis NOS H32.. Emphysema H320. Chronic bullous emphysema H3200 Segmental bullous emphysema H3201 Zonal bullous emphysema H3202 Giant bullous emphysema H3203 Bullous emphysema with collapse H320z Chronic bullous emphysema NOS H321. Panlobular emphysema H322. Centrilobular emphysema H32y. Other emphysema H32y0 Acute vesicular emphysema H32y1 Atrophic (senile) emphysema H32y2 MacLeod's unilateral emphysema H32yz Other emphysema NOS H32z. Emphysema NOS H36.. Mild chronic obstructive pulmonary disease H37.. Moderate chronic obstructive pulmonary disease H38.. Severe chronic obstructive pulmonary disease H39.. Very severe chronic obstructive pulmonary disease H3A.. End stage chronic obstructive airways disease (v23) H3y.. Other specified chronic obstructive airways disease H3y0. Chronic obstructive pulmonary disease with acute lower respiratory infection (v23) H3y1. Chronic obstructive pulmonary disease with acute exacerbation, unspecified (v23) H3z.. Chronic obstructive airways disease NOS
GP Questionnaire
1. Do you think this patient has COPD? Yes / No / Uncertain 2. What was the diagnosis of COPD based on? (please circle all that apply) Smoking history symptoms spirometry other (please describe) 3. Has a respiratory physician seen the patient and confirmed a diagnosis of COPD? 4. Does the patient have any other respiratory condition? If yes, than what?
Table S1: The PPV and proportion of patients diagnosed with COPD who also had cardiovascular disease or asthma Algorithm Number Number PPV and 95% Number Number PPV and 95% CI with confirmed CI with confirmed CVDx COPD asthma COPD COPD Code + 20 17 85.0, 59.6-95.6 18 14 72.2, 45.3-89.1 spirometry + COPD medication COPD Code + 24 20 83.3, 61.1-94.1 20 14 70.0, 45.0-87.0 spirometry COPD Code + 18 16 88.9, 61.1-97.6 16 9 56.3, 29.8-79.6 COPD medication COPD Code only 18 16 88.9, 61.1-97.6 15 12 80.0, 48.8-94.4 Bronchitis + COPD 21 8 38.1, 19.1-61.7 27 4 14.8, 5.3-35.1 medication Bronchitis only 19 8 42.1, 21.1-66.5 23 6 26.1, 11.4-49.1 Symptoms + 15 9 60.0, 31.8-82.9 19 4 21.1, 7.3-47.3 spirometry Symptoms only 9 2 22.2, 3.9-67.0 23 2 8.7, 1.9-31.4
Table S2: The PPV and proportion of patients diagnosed with COPD who were current smokers Algorithm Number Number PPV and 95% CI current confirmed COPD smokers COPD Code + 49 44 89.9, 77.1-95.8 spirometry + COPD medication COPD Code + 51 39 76.5, 62.5-86.4 spirometry COPD Code + COPD 55 46 83.6, 71.0-91.4 medication COPD Code only 47 41 87.2, 73.8-94.3 Bronchitis + COPD 67 34 50.7, 38.7-62.7 medication Bronchitis only 64 19 29.7, 19.6-42.3 Symptoms + 50 20 40.0, 27.1-54.5 spirometry Symptoms only 58 6 10.3, 4.6-21.7
Table S3: The PPV and proportion of patients diagnosed with COPD by COPD severity Algorithm GOLD 1 GOLD 2 GOLD 3 GOLD 4 Number Number confirmed, Number Number confirmed, (PPV (PPV and 95% CI) confirmed, (PPV confirmed, and 95% CI) and 95% CI) (PPV and 95% CI) COPD Code + spirometry 9, 34, 22, 6, + COPD medication (69.2, 36.5-89.8) (87.2, 71.8-94.8) (100) (100)
COPD Code + spirometry 8, 35, 20, 3, (66.7, 32.9-89.1) (83.3, 68.2-92.1) (100) (75, 4.1-99.5)
COPD Code + COPD 14, 32 20, 6, medication (82.4, 53.7-94.9) (84.2, 68.1-93.0) (95.2, 69.1-99.4) (100)
COPD Code only 14, 37, 14, 3, (82.4, 53.7-94.9) (86.0, 71.5-93.8) (93.3, 58.4-99.3) (100) Bronchitis + COPD 7, 20, 11, 2, medication (36.8, 17.3-62.0) (76.9, 55.6-89.9) (91.7, 49.9-99.2) (100)
Bronchitis only 3, 7, 10 1, (20.0, 5.6-51.2) (63.6, 28.8-83.3) (100) (100)
Symptoms + spirometry 4, 19, 10 1, (57.1, 15.0-90.9) (90.5, 66.0-97.9) (90.9, 46.3-99.1) (100)
Symptoms only 2, 6, 0 0 (40, 3.8-91.9) (100)
Table S4 : The PPV and proportion of patients diagnosed with COPD by timing of diagnosis Algorithm 2004 to end 2008 Post 2008
Number Number PPV and 95% Number Number PPV and 95% in confirmed CI in confirmed CI algorithm COPD algorithm COPD COPD Code + 32 28 87.5, 69.8-95.5 53 48 90.6, 78.7-96.1 spirometry + COPD medication COPD Code + 14 11 78.6, 46.0-94.0 66 56 84.8, 73.7-91.8 spirometry COPD Code + 27 23 85.2, 64.9-94.7 61 54 88.5, 77.4-94.5 COPD medication COPD Code only 21 16 76.2, 51.7-90.5 68 61 89.7, 79.6-95.1 Bronchitis + COPD 94 42 44.7, 34.8-55.0 5 2 40.0, 3.8-91.9 medication Bronchitis only 83 22 26.5, 18.0-37.2 5 4 80.0, 11.1-99.2 Symptoms + 63 28 44.4, 32.4-57.1 22 9 40.9, 21.6-63.5 spirometry Symptoms only 64 10 15.6, 8.5-27.0 26 1 3.8, 0.47-25.4