ACLY Antibody [6E7D7] Cat. No.: 23-966

ACLY Antibody [6E7D7]

Specifications

HOST SPECIES: Mouse

SPECIES REACTIVITY: Human, Monkey, Mouse

IMMUNOGEN: Recombinant protein of human ACLY

TESTED APPLICATIONS: Flow, ICC, WB

WB: ,1:500 - 1:2000

APPLICATIONS: ICC: ,1:50 - 1:200

Flow: ,1:20 - 1:50

POSITIVE CONTROL: 1) HeLa

2) K-562

3) COS-7

4) HepG2

5) Raji

6) NIH/3T3

PREDICTED MOLECULAR Observed: 121kDa WEIGHT:

October 2, 2021 1 https://www.prosci-inc.com/acly-antibody-6e7d7-23-966.html Properties

PURIFICATION: Affinity purification

CLONALITY: Monoclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: ACLY

ACL, ATPCL, CLATP, ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, citrate cleavage ALTERNATE NAMES: enzyme

GENE ID: 47

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl- CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and BACKGROUND: phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

October 2, 2021 2 https://www.prosci-inc.com/acly-antibody-6e7d7-23-966.html