March 21, 2017 u vol. 114 u no. 12

From the Cover

3246 Leaf initiation in plants E2337 Biomarker for cancerous cell subtypes E2460 Electron transport chains and enzyme activity 3026 Light–matter interplay in quantum chemistry 3258 Mirror self-recognition in monkeys

Contents

Cover image: Pictured is the pin-like THIS WEEK IN PNAS shoot of a mutant leafless (lfs) tomato 2995 In This Issue plant. Yossi Capua and Yuval Eshed used lfs tomato plants and hormone- inhibitor–induced leafless tomato plants to uncover the genetic basis of plant leaf LETTERS (ONLINE ONLY) initiation. The authors found that E2266 On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering microapplication of auxin (orange), Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, a phytohormone that plays a role in leaf and Paola Pizzo initiation, activated expression of auxin E2268 Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum reporters in both plant types, but failed and mitochondria? to initiate leaf production in the lfs Deborah Naon, Marta Zaninello, Marta Giacomello, Tatiana Varanita, Francesca Grespi, mutant plants. The authors suggest that Sowmya Lakshminaranayan, Annalisa Serafini, Martina Semenzato, Stephanie Herkenne, Maria the LEAFLESS gene might provide Isabel Herna´ndez-Alvarez, Antonio Zorzano, Diego De Stefani, Gerald W. Dorn II, a context-specific auxin response to and Luca Scorrano induce leaf initiation. See the article by E2270 Does influenza drive absolute humidity? – Capua and Eshed on pages 3246 3251. Edward B. Baskerville and Sarah Cobey Image courtesy of Yossi Capua. E2272 Reply to Baskerville and Cobey: Misconceptions about causation with synchrony and seasonal drivers George Sugihara, Ethan R. Deyle, and Hao Ye

OPINION—Leading scientists discuss current issues 2997 Why we need a centralized repository for isotopic data Jonathan N. Pauli, Seth D. Newsome, Joseph A. Cook, Chris Harrod, Shawn A. Steffan, Christopher J. O. Baker, Merav Ben-David, David Bloom, Gabriel J. Bowen, Thure E. Cerling, Carla Cicero, Craig Cook, Michelle Dohm, Prarthana S. Dharampal, Gary Graves, Robert Gropp, Keith A. Hobson, Chris Jordan, Bruce MacFadden, Suzanne Pilaar Birch, Jorrit Poelen, Sujeevan Ratnasingham, Laura Russell, Craig A. Stricker, Mark D. Uhen, Christopher T. Yarnes, and Brian Hayden

RETROSPECTIVE 3002 Stephen Fienberg: Superman of statistics Larry Wasserman

Free online through the PNAS open access option. PNAS u March 21, 2017 u vol. 114 u no. 12 u iii–vii Downloaded by guest on October 1, 2021 3050 Characterization of NiFe oxyhydroxide electrocatalysts COMMENTARIES by integrated electronic structure calculations 3004 The depressed brain in Parkinson’s disease: and spectroelectrochemistry Implications for an inflammatory biomarker Zachary K. Goldsmith, Aparna K. Harshan, James B. Brit Mollenhauer and Daniel Weintraub Gerken, Ma´rton Vo¨ro¨s, Giulia Galli, Shannon S. Stahl, See companion article on page 2735 in issue 10 of volume 114 and Sharon Hammes-Schiffer 3006 Glucagon antagonism in islet cell proliferation 3056 Tailoring porosity and rotational dynamics in a series E. Danielle Dean, Roger H. Unger, and William L. Holland of octacarboxylate metal-organic frameworks See companion articles on pages 2747 and 2753 in issue 10 of Florian Moreau, Daniil I. Kolokolov, Alexander G. Stepanov, volume 114 Timothy L. Easun, Anne Dailly, William Lewis, Alexander J. Blake, Harriott Nowell, Matthew J. Lennox, Elena Besley, Sihai 3009 Keeping the nitrogen-fixation dream alive Yang, and Martin Schro¨der Emilio Jimenez Vicente and Dennis R. Dean See companion article on page E2460 EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES E2285 Determining climate effects on US total PNAS PLUS agricultural productivity Xin-Zhong Liang, You Wu, Robert G. Chambers, Daniel L. 3012 Significance Statements Schmoldt, Wei Gao, Chaoshun Liu, Yan-An Liu, Chao Sun, Brief statements written by the authors about the significance of their and Jennifer A. Kennedy papers. 3062 Recombination reactions as a possible mechanism of mass-independent fractionation of sulfur isotopes in the Archean atmosphere of Earth PERSPECTIVE Dmitri Babikov 3017 LIGO and the opening of a unique observational window on the universe ENGINEERING Vassiliki Kalogera and Albert Lazzarini E2293 Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of INAUGURAL ARTICLE organoid behaviors Yu Shrike Zhang, Julio Aleman, Su Ryon Shin, Tugba Kilic, 3026 Atoms and molecules in cavities, from weak to Duckjin Kim, Seyed Ali Mousavi Shaegh, Solange Massa, Reza strong coupling in quantum-electrodynamics Riahi, Sukyoung Chae, Ning Hu, Huseyin Avci, Weijia Zhang, (QED) chemistry Antonia Silvestri, Amir Sanati Nezhad, Ahmad Manbohi, Fabio Johannes Flick, Michael Ruggenthaler, Heiko Appel, De Ferrari, Alessandro Polini, Giovanni Calzone, Noor Shaikh, and Angel Rubio Parissa Alerasool, Erica Budina, Jian Kang, Nupura Bhise, Joa˜o Ribas, Adel Pourmand, Aleksander Skardal, Thomas Shupe, Colin E. Bishop, Mehmet Remzi Dokmeci, Anthony Atala, PHYSICAL SCIENCES and Ali Khademhosseini E2375 Massive increase in visual range preceded the origin of APPLIED PHYSICAL SCIENCES terrestrial vertebrates 3035 Anatomy of news consumption on Facebook Malcolm A. MacIver, Lars Schmitz, Ugurcan Mugan, Todd D. Ana Lucı´a Schmidt, Fabiana Zollo, Michela Del Vicario, Murphey, and Curtis D. Mobley Alessandro Bessi, Antonio Scala, Guido Caldarelli, H. Eugene Stanley, and Walter Quattrociocchi PHYSICS 3040 Solar fuels photoanode materials discovery E2303 Entanglement of quantum clocks through gravity  by integrating high-throughput theory Esteban Castro Ruiz, Flaminia Giacomini, and Caslav Brukner and experiment Qimin Yan, Jie Yu, Santosh K. Suram, Lan Zhou, Aniketa Shinde, 3068 Higher-than-ballistic conduction of viscous Paul F. Newhouse, Wei Chen, Guo Li, Kristin A. Persson, John M. electron flows Gregoire, and Jeffrey B. Neaton Haoyu Guo, Ekin Ilseven, Gregory Falkovich, and Leonid S. Levitov CHEMISTRY E2275 Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers SOCIAL SCIENCES Davit Jishkariani, Christopher M. MacDermaid, Yam N. Timsina, Silvia Grama, Syeda S. Gillani, Masoumeh Divar, Srujana S. ECONOMIC SCIENCES Yadavalli, Ralph-Olivier Moussodia, Pawaret Leowanawat, 3074 Yellow taxis have fewer accidents than blue taxis Angely M. Berrios Camacho, Ricardo Walter, Mark Goulian, because yellow is more visible than blue Michael L. Klein, and Virgil Percec Teck-Hua Ho, Juin Kuan Chong, and Xiaoyu Xia 3026 Atoms and molecules in cavities, from weak to 3079 Impact of savings groups on the lives of the poor strong coupling in quantum-electrodynamics Dean Karlan, Beniamino Savonitto, Bram Thuysbaert, (QED) chemistry and Christopher Udry Johannes Flick, Michael Ruggenthaler, Heiko Appel, and Angel Rubio PSYCHOLOGICAL AND COGNITIVE SCIENCES 3044 Metallacycle-cored supramolecular assemblies with 3035 Anatomy of news consumption on Facebook tunable fluorescence including white-light emission Ana Lucı´a Schmidt, Fabiana Zollo, Michela Del Vicario, Mingming Zhang, Shouchun Yin, Jing Zhang, Zhixuan Zhou, Alessandro Bessi, Antonio Scala, Guido Caldarelli, Manik Lal Saha, Chenjie Lu, and Peter J. Stang H. Eugene Stanley, and Walter Quattrociocchi

iv u www.pnas.org Contents Downloaded by guest on October 1, 2021 3085 Classroom sound can be used to classify teaching BIOPHYSICS AND COMPUTATIONAL BIOLOGY practices in college science courses 3103 Accurate model annotation of a near-atomic Melinda T. Owens, Shannon B. Seidel, Mike Wong, Travis E. resolution cryo-EM map Bejines, Susanne Lietz, Joseph R. Perez, Shangheng Sit, Corey F. Hryc, Dong-Hua Chen, Pavel V. Afonine, Joanita Zahur-Saleh Subedar, Gigi N. Acker, Susan F. Akana, Brad Jakana, Zhao Wang, Cameron Haase-Pettingell, Wen Jiang, Balukjian, Hilary P. Benton, J. R. Blair, Segal M. Boaz, Katharyn E. Paul D. Adams, Jonathan A. King, Michael F. Schmid, Boyer, Jason B. Bram, Laura W. Burrus, Dana T. Byrd, Natalia and Wah Chiu Caporale, Edward J. Carpenter, Yee-Hung Mark Chan, Lily Chen, Amy Chovnick, Diana S. Chu, Bryan K. Clarkson, Sara E. 3109 Clinical concentrations of chemically diverse general Cooper, Catherine Creech, Karen D. Crow, Jose´R. de la Torre, anesthetics minimally affect lipid bilayer properties Wilfred F. Denetclaw, Kathleen E. Duncan, Amy S. Edwards, Karl F. Herold, R. Lea Sanford, William Lee, Olaf S. Andersen, Karen L. Erickson, Megumi Fuse, Joseph J. Gorga, Brinda and Hugh C. Hemmings Jr. Govindan, L. Jeanette Green, Paul Z. Hankamp, Holly E. Harris, 3115 Sensory domain contraction in histidine kinase CitA Zheng-Hui He, Stephen Ingalls, Peter D. Ingmire, J. Rebecca triggers transmembrane signaling in the Jacobs, Mark Kamakea, Rhea R. Kimpo, Jonathan D. Knight, Sara K. Krause, Lori E. Krueger, Terrye L. Light, Lance Lund, membrane-bound sensor Leticia M. Ma´rquez-Magan˜a, Briana K. McCarthy, Linda J. Michele Salvi, Benjamin Schomburg, Karin Giller, Sabrina McPheron, Vanessa C. Miller-Sims, Christopher A. Moffatt, Graf, Gottfried Unden, Stefan Becker, Adam Lange, Pamela C. Muick, Paul H. Nagami, Gloria L. Nusse, Kristine M. and Christian Griesinger Okimura, Sally G. Pasion, Robert Patterson, Pleuni S. Pennings, CELL BIOLOGY Blake Riggs, Joseph Romeo, Scott W. Roy, Tatiane Russo-Tait, Lisa M. Schultheis, Lakshmikanta Sengupta, Rachel Small, E2327 Rab5-regulated endocytosis plays a crucial role in Greg S. Spicer, Jonathon H. Stillman, Andrea Swei, Jennifer M. apical extrusion of transformed cells Wade, Steven B. Waters, Steven L. Weinstein, Julia K. Willsie, Sayaka Saitoh, Takeshi Maruyama, Yuta Yako, Mihoko Kajita, Diana W. Wright, Colin D. Harrison, Loretta A. Kelley, Gloriana Yoichiro Fujioka, Yusuke Ohba, Nobuhiro Kasai, Natsu Sugama, Trujillo, Carmen R. Domingo, Jeffrey N. Schinske, Shunsuke Kon, Susumu Ishikawa, Takashi Hayashi, Tomohiro and Kimberly D. Tanner Yamazaki, Masazumi Tada, and Yasuyuki Fujita 3216 Neural basis of impaired safety signaling in Obsessive E2337 Integrin-β4 identifies cancer stem cell-enriched Compulsive Disorder populations of partially mesenchymal carcinoma cells Annemieke M. Apergis-Schoute, Claire M. Gillan, Naomi A. Brian Bierie, Sarah E. Pierce, Cornelia Kroeger, Daniel G. Stover, Fineberg, Emilio Fernandez-Egea, Barbara J. Sahakian, Diwakar R. Pattabiraman, Prathapan Thiru, Joana Liu Donaher, and Trevor W. Robbins Ferenc Reinhardt, Christine L. Chaffer, Zuzana Keckesova, 3222 Predicting the knowledge–recklessness distinction in and Robert A. Weinberg the human brain E2347 SMN deficiency in severe models of spinal muscular Iris Vilares, Michael J. Wesley, Woo-Young Ahn, Richard J. atrophy causes widespread intron retention and Bonnie, Morris Hoffman, Owen D. Jones, Stephen J. Morse, DNA damage Gideon Yaffe, Terry Lohrenz, and P. Read Montague Mohini Jangi, Christina Fleet, Patrick Cullen, Shipra V. Gupta, Shila Mekhoubad, Eric Chiao, Norm Allaire, C. Frank Bennett, Frank Rigo, Adrian R. Krainer, Jessica A. Hurt, John P. Carulli, SUSTAINABILITY SCIENCE and John F. Staropoli E2285 Determining climate effects on US total E2357 Genetic dissection of colorectal cancer progression agricultural productivity by orthotopic transplantation of engineered Xin-Zhong Liang, You Wu, Robert G. Chambers, Daniel L. cancer organoids Schmoldt, Wei Gao, Chaoshun Liu, Yan-An Liu, Chao Sun, Arianna Fumagalli, Jarno Drost, Saskia J. E. Suijkerbuijk, Ruben and Jennifer A. Kennedy van Boxtel, Joep de Ligt, G. Johan Offerhaus, Harry Begthel, 3091 Consequences of a price incentive on free riding and Evelyne Beerling, Ee Hong Tan, Owen J. Sansom, Edwin electric energy consumption Cuppen, Hans Clevers, and Jacco van Rheenen Mikael Elinder, Sebastian Escobar, and Ingel Petre´ 3121 Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling Kai Kessenbrock, Prestina Smith, Sander Christiaan Steenbeek, BIOLOGICAL SCIENCES Nicholas Pervolarakis, Raj Kumar, Yasuhiro Minami, Andrei Goga, Lindsay Hinck, and Zena Werb ANTHROPOLOGY 3127 Functional characterization of CFI-402257, a potent 3097 Hunter-gatherer residential mobility and the marginal and selective Mps1/TTK kinase inhibitor, for the value of rainforest patches treatment of cancer Vivek V. Venkataraman, Thomas S. Kraft, Nathaniel J. Dominy, Jacqueline M. Mason, Xin Wei, Graham C. Fletcher, Reza and Kirk M. Endicott Kiarash, Richard Brokx, Richard Hodgson, Irina Beletskaya, Mark R. Bray, and Tak W. Mak BIOCHEMISTRY 3133 Stepwise unfolding supports a subunit model for E2310 Deep-sea vent phage DNA polymerase specifically vertebrate kinetochores initiates DNA synthesis in the absence of primers Giulia Vargiu, Alexandr A. Makarov, James Allan, Tatsuo Fukagawa, Daniel G. Booth, and William C. Earnshaw Bin Zhu, Longfei Wang, Hitoshi Mitsunobu, Xueling Lu, Alfredo J. Hernandez, Yukari Yoshida-Takashima, Takuro Nunoura, Stanley Tabor, and Charles C. Richardson DEVELOPMENTAL BIOLOGY E2319 Arsenic trioxide targets MTHFD1 and SUMO-dependent E2365 miR-285–Yki/Mask double-negative feedback loop nuclear de novo thymidylate biosynthesis mediates blood–brain barrier integrity in Drosophila Elena Kamynina, Erica R. Lachenauera, Aislyn C. DiRisio, Dong Li, Yanling Liu, Chunli Pei, Peng Zhang, Linqing Pan, Jing Rebecca P. Liebenthal, Martha S. Field, and Patrick J. Stover Xiao, Songshu Meng, Zengqiang Yuan, and Xiaolin Bi

Contents PNAS u March 21, 2017 u vol. 114 u no. 12 u v Downloaded by guest on October 1, 2021 3139 Integration of Shh and Fgf signaling in controlling Hox MEDICAL SCIENCES gene expression in cultured limb cells E2430 Immune protection against reinfection with Alan R. Rodrigues, Nayuta Yakushiji-Kaminatsui, Yuji Atsuta, nonprimate hepacivirus Guillaume Andrey, Patrick Schorderet, Denis Duboule, Stephanie Pfaender, Stephanie Walter, Elena Grabski, Daniel Todt, and Clifford J. Tabin Janina Bruening, Ine´s Romero-Brey, Theresa Gather, Richard J. P. Brown, Kerstin Hahn, Christina Puff, Vanessa M. Pfankuche, EVOLUTION Florian Hansmann, Alexander Postel, Paul Becher, Volker Thiel, E2375 Massive increase in visual range preceded the origin of Ulrich Kalinke, Bettina Wagner, Ralf Bartenschlager, Wolfgang terrestrial vertebrates Baumga¨rtner, Karsten Feige, Thomas Pietschmann, Jessika M. V. Cavalleri, and Eike Steinmann Malcolm A. MacIver, Lars Schmitz, Ugurcan Mugan, Todd D. Murphey, and Curtis D. Mobley 3169 ZNF503/Zpo2 drives aggressive breast cancer E2385 The presumed ginkgophyte Umaltolepis has progression by down-regulation of seed-bearing structures resembling those GATA3 expression of Peltaspermales and Umkomasiales Payam Shahi, Chih-Yang Wang, Devon A. Lawson, Euan M. Slorach, Angela Lu, Ying Yu, Ming-Derg Lai, Hugo Gonzalez Fabiany Herrera, Gongle Shi, Niiden Ichinnorov, Masamichi Velozo, and Zena Werb Takahashi, Eugenia V. Bugdaeva, Patrick S. Herendeen, and Peter R. Crane 3175 Phosphoproteins in extracellular vesicles as candidate E2392 Unified reduction principle for the evolution of markers for breast cancer mutation, migration, and recombination I-Hsuan Chen, Liang Xue, Chuan-Chih Hsu, Juan Sebastian Paez Paez, Li Pan, Hillary Andaluz, Michael K. Wendt, Anton B. Iliuk, Lee Altenberg, Uri Liberman, and Marcus W. Feldman Jian-Kang Zhu, and W. Andy Tao E2401 Multiple origins of viral capsid proteins from 3181 Ablation of cytochrome P450 omega-hydroxylase cellular ancestors 4A14 gene attenuates hepatic steatosis and fibrosis Mart Krupovic and Eugene V. Koonin Xiaoyan Zhang, Sha Li, Yunfeng Zhou, Wen Su, Xiongzhong 3145 Discovery of an endogenous Deltaretrovirus in the Ruan, Bing Wang, Feng Zheng, Margaret Warner, Jan-A˚ke genome of long-fingered bats (Chiroptera: Miniopteridae) Gustafsson, and Youfei Guan    Helena Farkasova´, Toma´s Hron, Jan Paces, Pavel Hulva, Petr 3186 mTORC1/2 inhibition preserves ovarian function and Benda, Robert James Gifford, and Daniel Elleder fertility during genotoxic chemotherapy Kara N. Goldman, Devon Chenette, Rezina Arju, Francesca E. GENETICS Duncan, David L. Keefe, Jamie A. Grifo, and Robert J. Schneider E2411 Conserved forkhead dimerization motif controls DNA 3192 BAP1 inhibits the ER stress gene regulatory network replication timing and spatial organization of and modulates metabolic stress response chromosomes in S. cerevisiae Fangyan Dai, Hyemin Lee, Yilei Zhang, Li Zhuang, Hui Yao, A. Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K. Villwock, Yuanxin Xi, Zhen-Dong Xiao, M. James You, Wei Li, Xiaoping Su, Christian Linke, Matteo Barberis, Lin Chen, and Boyi Gan and Oscar M. Aparicio 3151 Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis MICROBIOLOGY − − screen in an Arf / mouse model E2440 Polyphosphate granule biogenesis is temporally and Emilie A. Chapeau, Agnieszka Gembarska, Eric Y. Durand, functionally tied to cell cycle exit during starvation Emeline Mandon, Claire Estadieu, Vincent Romanet, Marion in Pseudomonas aeruginosa Wiesmann, Ralph Tiedt, Joseph Lehar, Antoine de Weck, Lisa R. Racki, Elitza I. Tocheva, Michael G. Dieterle, Meaghan C. Roland Rad, Louise Barys, Sebastien Jeay, Stephane Ferretti, Sullivan, Grant J. Jensen, and Dianne K. Newman Audrey Kauffmann, Esther Sutter, Armelle Grevot, Pierre Moulin, Masato Murakami, William R. Sellers, Francesco Hofmann, E2450 Simplified and representative bacterial community of and Michael Rugaard Jensen maize roots Ben Niu, Joseph Nathaniel Paulson, Xiaoqi Zheng, IMMUNOLOGY AND INFLAMMATION and Roberto Kolter E2420 Myocardial aging as a T-cell–mediated phenomenon E2460 Modular electron-transport chains from eukaryotic Gustavo Campos Ramos, Anne van den Berg, Vaˆnia organelles function to support nitrogenase activity Nunes-Silva, Johannes Weirather, Laura Peters, Matthias Jianguo Yang, Xiaqing Xie, Mingxuan Yang, Ray Dixon, Burkard, Mike Friedrich, Ju¨rgen Pinnecker, Marco Abeßer, and Yi-Ping Wang Katrin G. Heinze, Kai Schuh, Niklas Beyersdorf, Thomas See Commentary on page 3009 Kerkau, Jocelyne Demengeot, Stefan Frantz, and Ulrich Hofmann 3198 Comparative genomics uncovers the prolific and distinctive metabolic potential of the 3157 Engineered erythrocytes covalently linked to cyanobacterial genus Moorea antigenic peptides can protect against Tiago Leao, Guilherme Castela˜o, Anton Korobeynikov, Emily A. autoimmune disease Monroe, Sheila Podell, Evgenia Glukhov, Eric E. Allen, Novalia Pishesha, Angelina M. Bilate, Marsha C. Wibowo, William H. Gerwick, and Lena Gerwick Nai-Jia Huang, Zeyang Li, Rhogerry Dhesycka, Djenet Bousbaine, Hojun Li, Heide C. Patterson, Stephanie K. Dougan, 3204 Resuscitation of Pseudomonas aeruginosa from Takeshi Maruyama, Harvey F. Lodish, and Hidde L. Ploegh dormancy requires hibernation promoting factor (PA4463) for ribosome preservation 3163 Sensing of cell stress by human γδ TCR-dependent Tatsuya Akiyama, Kerry S. Williamson, Robert Schaefer, Shawna recognition of annexin A2 Pratt, Connie B. Chang, and Michael J. Franklin Romain Marlin, Angela Pappalardo, Hannah Kaminski, Carrie R. Willcox, Vincent Pitard, Sonia Netzer, Camille Khairallah, 3210 Structure of deformed wing virus, a major honey Anne-Marie Lomenech, Christelle Harly, Marc Bonneville, bee pathogen  Jean-Franc¸ois Moreau, Emmanuel Scotet, Benjamin E. Willcox, Karel Skubnı´k, Jirı´ Nova´cek, Tibor Fu¨zik, Antonı´nPridal, Benjamin Faustin, and Julie De´chanet-Merville Robert J. Paxton, and Pavel Plevka

vi u www.pnas.org Contents Downloaded by guest on October 1, 2021 NEUROSCIENCE 3240 Myosin filament activation in the heart is tuned to the E2466 Amyotrophic lateral sclerosis-linked mutations mechanical task increase the viscosity of liquid-like TDP-43 Massimo Reconditi, Marco Caremani, Francesca Pinzauti, RNP granules in neurons Joseph D. Powers, Theyencheri Narayanan, Ger J. M. Stienen, Pallavi P. Gopal, Jeffrey J. Nirschl, Eva Klinman, Marco Linari, Vincenzo Lombardi, and Gabriella Piazzesi and Erika L. F. Holzbaur PLANT BIOLOGY E2476 Synchronous circadian voltage rhythms with E2533 Auxin response cell-autonomously controls ground asynchronous calcium rhythms in the tissue initiation in the early Arabidopsis embryo suprachiasmatic nucleus Barbara K. Mo¨ller, Colette A. ten Hove, Daoquan Xiang, Nerys Ryosuke Enoki, Yoshiaki Oda, Michihiro Mieda, Daisuke Ono, Williams, Lorena Gonza´lez Lo´pez, Saiko Yoshida, Margot Smit, Sato Honma, and Ken-ichi Honma Raju Datla, and Dolf Weijers E2486 Novel combinatorial screening identifies neurotrophic 3246 Coordination of auxin-triggered leaf initiation by factors for selective classes of motor neurons tomato LEAFLESS Se´bastien Schaller, Dorothe´e Buttigieg, Alysson Alory, Arnaud Yossi Capua and Yuval Eshed Jacquier, Marc Barad, Mark Merchant, David Gentien, Pierre de la Grange, and Georg Haase POPULATION BIOLOGY E2494 Correlated variability modifies working memory fidelity in primate prefrontal neuronal ensembles 3252 Black-swan events in animal populations Sean C. Anderson, Trevor A. Branch, Andrew B. Cooper, Matthew L. Leavitt, Florian Pieper, Adam J. Sachs, and Nicholas K. Dulvy and Julio C. Martinez-Trujillo 3216 Neural basis of impaired safety signaling in Obsessive PSYCHOLOGICAL AND COGNITIVE SCIENCES Compulsive Disorder 3258 Spontaneous expression of mirror self-recognition in Annemieke M. Apergis-Schoute, Claire M. Gillan, Naomi A. monkeys after learning precise visual-proprioceptive Fineberg, Emilio Fernandez-Egea, Barbara J. Sahakian, association for mirror images and Trevor W. Robbins Liangtang Chang, Shikun Zhang, Mu-ming Poo, 3222 Predicting the knowledge–recklessness distinction in and Neng Gong the human brain Iris Vilares, Michael J. Wesley, Woo-Young Ahn, Richard J. Bonnie, Morris Hoffman, Owen D. Jones, Stephen J. Morse, CORRECTIONS (ONLINE ONLY) Gideon Yaffe, Terry Lohrenz, and P. Read Montague BIOPHYSICS AND COMPUTATIONAL BIOLOGY 3228 Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety E2540 Quantifying antiviral activity optimizes drug Xin Su, Jing-Jing Chen, Lin-Yun Liu, Qian Huang, Li-Zhao combinations against hepatitis C virus infection Zhang, Xiao-Yang Li, Xiang-Nan He, Wenlian Lu, Shan Yoshiki Koizumi, Hirofumi Ohashi, Syo Nakajima, Yasuhito Sun, Huawei Li, and Yong-Chun Yu Tanaka, Takaji Wakita, Alan S. Perelson, Shingo Iwami, and Koichi Watashi

PHARMACOLOGY CELL BIOLOGY E2293 Multisensor-integrated organs-on-chips platform for E2542 A set of NF-κB–regulated microRNAs induces automated and continual in situ monitoring of acquired TRAIL resistance in Lung cancer organoid behaviors Young-Jun Jeon, Justin Middleton, Taewan Kim, Alessandro Yu Shrike Zhang, Julio Aleman, Su Ryon Shin, Tugba Kilic, Lagana`, Claudia Piovan, Paola Secchiero, Gerard J. Nuovo, Ri Duckjin Kim, Seyed Ali Mousavi Shaegh, Solange Massa, Reza Cui, Pooja Joshi, Giulia Romano, Gianpiero Di Leva, Bum-Kyu Riahi, Sukyoung Chae, Ning Hu, Huseyin Avci, Weijia Zhang, Lee, Hui-Lung Sun, Yonghwan Kim, Paolo Fadda, Hansjuerg Antonia Silvestri, Amir Sanati Nezhad, Ahmad Manbohi, Fabio Alder, Michela Garofalo, and Carlo M. Croce De Ferrari, Alessandro Polini, Giovanni Calzone, Noor Shaikh, Parissa Alerasool, Erica Budina, Jian Kang, Nupura Bhise, Joa˜o NEUROSCIENCE Ribas, Adel Pourmand, Aleksander Skardal, Thomas Shupe, E2543 A natural product inhibits the initiation of α-synuclein Colin E. Bishop, Mehmet Remzi Dokmeci, Anthony Atala, and Ali Khademhosseini aggregation and suppresses its toxicity Michele Perni, Ce´line Galvagnion, Alexander Maltsev, Georg Meisl, E2504 Deactivation kinetics of acid-sensing ion channel 1a Martin B. D. Mu¨ller, Pavan K. Challa, Julius B. Kirkegaard, Patrick are strongly pH-sensitive Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, David M. MacLean and Vasanthi Jayaraman Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan PHYSIOLOGY Bax, Michael Zasloff, and Christopher M. Dobson E2514 Mechanisms regulating angiogenesis underlie seasonal control of pituitary function Jennifer Castle-Miller, David O. Bates, and Domingo J. Tortonese SI CORRECTION (ONLINE ONLY)

E2524 Lys49 myotoxin from the Brazilian lancehead pit viper PSYCHOLOGY, EVOLUTION elicits pain through regulated ATP release E2544 Cumulative cultural evolution in the laboratory: Chuchu Zhang, Katalin F. Medzihradszky, Elda E. Sa´nchez, An experimental approach to the origins of Allan I. Basbaum, and David Julius structure in human language ’ – 3234 Hysteresis of KcsA potassium channel s activation Simon Kirby, Hannah Cornish, and Kenny Smith deactivation gating is caused by structural changes at the channel’s selectivity filter Cholpon Tilegenova, D. Marien Cortes, and Luis G. Cuello ix Subscription Form

Contents PNAS u March 21, 2017 u vol. 114 u no. 12 u vii Downloaded by guest on October 1, 2021