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This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University Record by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. Medical News: David Clayson endows #1 Inside: University Opera to stage works Washington People: Bruce Backus neurology chair, psychology scholarship O by Argento, Menotti on March 23-25 works to maintain researchers' safety 8

March 9, 2001 Volume 25 No. 22 ^feshington University in StLouis Jupiter moons brought into focus by McKinnon Evidence for wet, slushy Ganymede found Stress, chaos formed lo's huge mountains

BY TONY FITZPATRICK advantage of the BY TRENT C. STOCKTON is the most geologically active body in the numerous Voyager solar system, with mountains up to 55,000 Planetary scientists studying Jupiter's images and the higher t takes a lot of stress feet tall. (In comparison, the summit of icy moon Ganymede have combined resolution of the Galileo and a little chaos to Mount Everest is a meager 29,000 feet.) stereo images from the Galileo ones, point to volcanism I create some of the lo's surface is dotted with active mission with 1970s Voyager images and as the main impetus tallest mountains in volcanoes spewing plumes of sulfurous gas found provocative features on its surface. behind the troughs. our solar system. and emitting vast streams of scorching lava. The researchers have mapped long swathes "This is a new kind of That is the theory The heat released from Io - from lava as of bright flat terrain that they think is stereo topographical An irregularly shaped caldera, proposed by University hot as 1,800 degrees Kelvin (2,800 degrees evidence of water or slush that emerged 1 information over or pit, within a bright swath earth and planetary Fahrenheit) - is about 25 to 30 times billion, years or so ago. hundreds of kilometers called Sippar Sulcus on scientists studying greater per square foot than the heat This bright terrain, long since frozen across Ganymede," said Jupiter's moon Ganymede mountain formation released from Earth. This makes lo's over, lies uniformly in troughs about one William B. McKinnon, dominates this image taken by and volcanic activity on mountains, which are not volcanoes, all the kilometer (a little over a half-mile) beneath Ph.D., professor of earth NASA's Galileo spacecraft. Io, one of Jupiter's many more interesting, because at these tempera- Ganymede's older, darker, cratered terrain. and planetary sciences in moons. The researchers tures planetary scientists would expect the Ganymede, the largest moon in the solar Arts & Sciences and co- analyzed images taken surface to be liquid or soft, with little system, is an icy satellite of Jupiter and is author of the study published in Nature on by the Galileo and Voyager spacecraft and topography. larger than the planet Mercury. The roles March 1. found that lo's enigmatic mountains may How, then, can mountains form in such a that volcanism and various forms of "What we think we're seeing is evidence be the combined result of heating, melting furnace-like environment? William B. tectonics have played in molding the . of an eruption of water on the surface of and tilting of giant blocks of crust. McKinnon, Ph.D., professor of earth and complex topography of Ganymede have Ganymede," McKinnon said. "We see these The origin of lo's prodigious mountains planetary sciences in Arts & Sciences, been hotly debated over the years. long, smooth troughs that step down up to has intrigued planetary scientists for over Andrew J. Dombard, who recently earned a But the newly created images, taking See Ganymede, Page 6 20 years. Io, about the size of Earth's moon, See Io, Page 6 Brain damage contributor identified

BY GILA RECKESS

Researchers have identified a protein that plays an impor- tant role in neonatal brain injury. The protein, clusterin, might also contribute to adult brain damage — for example after spinal cord injury or stroke. The results appear in the March issue of the journal Nature Medicine. The first author is Byung Hee Han, M.D., research associate in neurology at the School of Medicine. David M. Holtzman, M.D., associate professor of neurology and of molecular biology and pharmacol- ogy, led the research team. Blockage of blood flow to the brain before or during birth can Omni roll Wendy Miyuki Whiteside, junior biology major in Arts & Sciences, performs during the George Warren Brown School of temporarily deprive the brain of Social Work's seventh annual International Festival in Brown Hall. Whiteside and Abby Shelton (left), sophomore Japanese major in oxygen and other nutrients, as Arts & Sciences, are members of the St. Louis Osuwa Taiko at Washington University. They joined about 75 international social work happens when an adult has a students in presenting native foods and entertainment at the March 2 celebration. stroke. Without a continuous supply of oxygen, some brain cells die or are damaged, WU to invest up to $40 million in venture capital funds causing hypoxic- To support and encourage the with the objective of helping ischemic development of new St. Louis establish the St. Louis region as a "The focus of the University's strategy is to encourage (H-I) injury. science-and-technology compa- center of science-and-technology- The outcome nies, the University's Board of based industries," Wrighton said. investment in science-based companies, with the objective of may be long- Trustees will invest up to $40 "With the wise counsel and helping establish the St. Louis region as a center of science- term cogni- tive difficul- million of the institution's strong support of the Trustees — and-technology-based industries." endowment in St. Louis-based especially Board Chair John F. ties, seizures Holtzman: Led venture capital funds, according McDonnell and Investment MARK S. WRIGHTON and motor research team to Chancellor Mark S. Wrighton. Committee Chair John H. Biggs problems, as The Trustee Investment Commit- — we see this as a way to parallel in cerebral palsy. tee made the decision at its March the University's strength in "The University is the region's capital funds in the St. Louis area Scientists know of two main 2 meeting. science and research with the largest research enterprise, and and then to invest in each based types of cell death, each triggered by "The focus of the University's region's potential to grow as a many of the innovations discov- on its future potential," said a different cascade of biological strategy is to encourage invest- magnet for high-technology ered by our faculty will benefit Barbara Feiner, vice chancellor for events. In apoptosis, cells shrink and ment in science-based companies, business and industry," he said. from strong technology-based finance. die. In necrosis, cells swell and burst. As generators of ideas and enterprises in St. Louis," Wrighton "The Trustees will develop a Apoptosis accounts for Spring Break inventions, the faculty scientists of said. process through which the about half of the cell death that the University and other St. Louis The funds invested by the University will select the venture occurs after H-I injury to the The Record will not publish research institutions seek to University will only go to venture capital firms, monitor their developing brain. Researchers the week of Spring Break, stimulate the transfer of impor- capital funds, not the actual high- progress, and assure that their have identified several ways to March 12-16. Look for our next tant discoveries and technology technology businesses themselves. activities are consistent with the block apoptosis and thereby issue March 23. from their laboratories to the "Our strategy is to select a few University's expectations for the lessen brain deterioration. public, Wrighton said. strongly committed venture See Investment, Page 2 See Protein, Page 7 2 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS Intellectual property, technology focus of new law school program

BY ANN NICHOLSON expanded course offerings. Dorsey D. Ellis Jr., J.D., chair of Recognizing the exponential the advisory board for the new growth in legal issues related program and the William R. to new technologies from Orthwein Distinguished Professor cyberspace to biotechnology, the of Law, noted that a number of School of Law is launching a new factors will strengthen the new Master of Laws (LL.M.) Program LL.M.'s offerings. in Intellectual Property and "The new LL.M. program will Technology Law. capitalize on the University's "The new master's degree prominence in information and program is designed to provide biotechnology, the region's unique graduates of both U.S. and strengths in biotechnology, and international law schools with the law school's own teaching and specialized, advanced study and scholarly expertise in interna- practical skills training in this tional and comparative law and in increasingly complex area of the intellectual property law," law," said Joel Seligman, J.D., law Ellis said. school dean and the Ethan A. H. The program's 26-member Shepley University Professor. "The advisory board is made up of program builds on our strengths in attorneys at the World Intellectual Olln professorship Barbara A. Schaal, Ph.D., professor of biology in Arts & Sciences and of intellectual property law and our Property Organization, at the U.S. genetics at the School of Medicine, was installed as the Spencer T. Olin Professor of Biology in successful LL.M. programs in tax Patent and Trademark Office and Arts & Sciences on March 1 in a ceremony in Duncker Hall. Joining Schaal (left) at the reception and for international students." practicing intellectual property are Mary Dell Pritzlaff, University Board of Trustees member and daughter of Spencer T. Olin, and The American Bar Association law at leading law firms and Ralph S. Quatrano, Ph.D., Spencer T. Olin Professor in Arts & Sciences and chair of the Depart- businesses, both in St. Louis ment of Biology. Schaal joined the biology department in 1980 and served as chair from 1993-97. recently granted permission for the intellectual property program, one and nationally. of only a half-dozen among the 183 The master's degree courses accredited law schools in the U.S. will be taught by law school University Libraries to host 'James Merrill: A Celebration' The law school officially will faculty who are nationally and inaugurate the program at a major internationally recognized in their Washington University conference on "Intellectual Property, respective fields and adjunct Libraries will host a Panelist Information Digital Technology and Electronic professors, many of whom also symposium titled "James Commerce" on April 6-7. serve on the advisory board. Merrill: A Celebration" on • Mary Jo Bang, assistant poems have appeared in The "The explosion of new tech- Patent law expert F. Scott Kieff, March 22. professor of English in Arts & New York Times Book Review, nologies driving the J.D., visiting assistant James Merrill (1925-1995) Sciences, is the author of two The New Yorker, The Atlantic, U.S. and global professor at Northwest- has been called "the leading lyric books of poetry and recipient Rolling Stone and many other economies — combined ern University School of poe: of his generation." A of the Bakeless Prize. publications. She has won with a dramatic rise in Law and co-author of the prolific writer of poetry, fiction ' • William Gass, the David grants and awards from the the importance of casebook and treatise and drama, Merrill won a May Distinguished Professor Guggenheim Foundation, the intellectual property — "Principles of Patent Pulitzer Prize for "Divine Emeritus in the Humanities in Missouri Arts Council and the presents significant new Law," also will join the Comedies" and two National Arts & Sciences and former Ingram-Merrill Foundation. challenges to the legal Washington University Book Awards for "Nights and director of the International • Carl Phillips, director of profession," said Charles law school faculty this fall Days" and "Mirabell: Books of Writers Center at the Univer- the Creative Writing Program R. McManis, J.D., and teach in the LL.M. Number." sity, has written many works of in Arts & Sciences, has professor of law and program. Merrill also received the fiction, literary criticism and authored several books of director of the new McManis: Director Interdisciplinary Bollingen Prize in Poetry, a philosophy. He has won two poetry. He has been a finalist LL.M. program. of new program opportunities will National Book Critics Circle National Book Critics Circle for the National Book Award "Today's easy dissemi- abound between the new Award for "The Changing Light Awards - for "Habitations of and the National Book Critics nation of information globally also intellectual property program and at Sandover" and the Rebekah the Word" and for "Finding a Circle Award and has won underlines the need to increase the School of Medicine's Genome Johnson Bobbitt National Prize Form" - and a Lannan Lifetime prizes and fellowships from intellectual property protections Sequencing Center and Center for for Poetry. He served as Achievement Award. the Guggenheim Foundation and to address such complex issues Computational Biology; School of Connecticut's poet laureate. • Jack Hagstrom, professor and the Library of Congress. across different legal cultures." Engineering and Applied Science's Merrill had a long association emeritus of pathology at • Sherod Santos, professor Intellectual property law Center for Biocybemetics and with the University Libraries. As Columbia College of Physi- of English at the University of encompasses protections for Intelligence Systems and its the primary repository for his cians and Surgeons, co- Missouri, Columbia, has "creations of the mind," ranging Institute of Biological and papers, the libraries' Special authored a bibliography of the written four books of poetry. from patents for inventions to Medical Engineering; and the Collections department houses a works of Thorn Gunn and is He has won an Award for copyrights for literary and artistic Philosophy-Neurosciences- nearly comprehensive collection working on a bibliography of Literary Excellence from the works to trademarks associated Psychology Program in Arts & of works by or about Merrill, as Merrill's work. American Academy of Arts with commercial products to trade Sciences, Ellis said. well as most of his manuscripts • Tim Materer, professor of and Letters and fellowships secret protections for manufactur- Additionally, the law school's and a wide array of photo- English at the University of from the Ingram-Merrill ing processes or product formulas. Institute for Global Legal Studies graphs, interviews and ephem- Missouri, Columbia, wrote Foundation, the Guggenheim In today's high-tech world, and Center for Interdisciplinary era. "Merrill's Apocalypse" and Foundation and the National intellectual property issues are Studies will include intellectual This symposium marks the "Modernist Alchemy: Poetry Endowment for the Arts. becoming commonplace with property topics among their areas release of Merrill's "Collected and the Occult," as well as • Stephen Yenser, professor recent headlines highlighting the of scholarly interest. Poems" (Knopf, February 2001) several other studies of modern of English and director of Napster dispute over music that Businesses are increasingly and recognizes the passage of literature. creative writing at the can be downloaded over the dealing with intellectual property what would have been his 75th • J.D. McClatchy is co-editor University of California-Los Internet, ongoing conflicts over issues, demonstrating the birthday March 3. of James Merrill's newly Angeles, co-edited Merrill's Internet domain names and battles substantial need for lawyers Scheduled events include a published "Collected Poems." "Collected Poems" and wrote over the application of techniques trained in this area, McManis said. lecture by Timothy Materer and He is editor of The Yale Review "The Consuming Myth: The for genetically engineering crops. For example, the St. Louis region a discussion of Merrill's work by and has written several books Work of James Merrill." His Beginning this fall, the new is experiencing tremendous panelists Jack Hagstrom, J.D. of poetry and literary essays. In poems and essays have LL.M. program will offer introduc- growth in biotechnology research McClatchy and Stephen Yenser. 1996, he was named a Chancel- appeared in The Nation, The tory courses and advanced and development through the This program will be held in the lor of the Academy of Ameri- New Yorker, The Yale Review, seminars in intellectual property Missouri Botanical Garden, Moot Courtroom in Anheuser- can Poets. The Paris Review, Poetry and law as well as in a wide range of Monsanto/Pharmacia, the Donald Busch Hall. • Lynne McMahon, other magazines. He has won related topics including antitrust, Danforth Plant Science Center A reception and exhibition of professor of English and a Discovery Award, two international investment law, and several new corporate items from the libraries' James creative writing at the Univer- Fulbright teaching fellowships, entertainment law, sports law, incubators for biotechnology Merrill Collection will immedi- sity of Missouri, Columbia, has an Ingram Merrill Foundation bioethics, and legal issues stem- firms. The law school's new ately follow in the Special published three books of Award and the B.F. Connors ming from the human genome intellectual property program will Collections department in Olin poetry. Her essays, reviews, or Prize for Poetry. project. Students in the juris help provide the legal expertise Library, Level 5. "Collected doctor (J.D.) program will also be needed to make St. Louis a Poems" and several other books able to take advantage of these See Law program, Page 6 by Merrill and recent works by McClatchy, Lynne McMahon, program or to register online, visit program participants will be Carl Phillips, Sherod Santos and www.library.wusd.edu/units/spec/ available for purchase. Items Stephen Yenser reading selected merrill. To be added to the mailing from the program will be on poems. This program will list, call the Special Collections Record (USPS 600-430; ISSN 1043-0520), display in Special Collections conclude with a slide show on department, 935-5495. Volume 25, Number 22/March 9,2001. through May 22. Merrill, compiled by J.D. For more information about Published for the faculty, staff and friends A reading of Merrill poems McClatchy. the Merrill Collection at Univer- Washington University community news of Washington University. Produced weekly begins at 7:30 p.m. in Simon The day's events are free, but sity Libraries visit www.library. Editor Kevin M. Kiley during the school year, except school Assistant Editor Jessica N. Roberts holidays, and monthly during June, July Hall Auditorium with Mary Jo registration is required by March wustl.edu/units/spec/manu- and August by the Office of Public Affairs, Bang, William Gass, J.D. 15. For more details about the Assistant Editor Neil Schoenherr scripts/mlc/merrill. Associate Vice Chancellor Judith Jasper Leicht Washington University, Campus Box 1070, Acting Executive Editor Donna Kettenbach One Brookings Drive, St. Louis, MO 63130. our region, and — if successful faculty — such as scholar- Medical News Editor Diane Duke Williams Periodicals postage paid at St. Louis, MO. Production Carl Jacobs — will help advance high- ships, endowed professorships Where to send address changes, News & Comments Investment technology businesses. We also and general academic corrections: hope to influence other funding (314) 935-6603 • from Page 1 program support." Campus Box 1070 Postmaster and non-employees Record, sources in the St. Louis region "We believe in the poten- [email protected] Washington University, Campus Box 1070, to do the same. As with all of tial of St. Louis, and we hope Medical News One Brookings Drive, St. Louis, MO 63130. use of these funds," said our endowment investments, this will encourage other local McDonnell, the retired chairman (314)286-0119 Employees Office of Human Resources, we want this effort to be institutions and pension funds Campus Box 8508 Washington University, Campus Box 1184, of the board of the former successful in supporting the to invest in a successful future [email protected] One Brookings Drive, St. Louis, M0 63130. McDonnell Douglas Corporation. important benefits that the for businesses and for science Feiner added, "We believe this University's endowment and technology in the region," effort will bring great benefit to I ^VfehingtonUniversity in St iDuis provides our students and McDonnell said. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS March 9, 2001 3 Medical School Update ■ - David Clayson endows chair in neurology, scholarship in psychology

BY GILA RECKESS Arts & Sciences in 1963. He tor and researcher for more orthopaedic surgery in adoles- said David G. Mohler, M.D., a established the professorship to than 38 years. He was head and cents and children. former student of Clayson's and Alumnus David Clayson, support scientists whose research director of clinical training of The legacy he leaves with this now an assistant professor of Ph.D., has established a is relevant to developing effective psychology in psychiatry at the professorship and scholarship orthopaedic surgery at Stanford professorship in the treatments of ALS and other medical college for 25 years. mirror Clayson's lifelong University. "As a professor, I've Department of Neurology and a neurodegenerative diseases. Clayson also was co-founder dedication to teaching. He was tried to model my own ap- scholarship for graduate studies "I am saddened by Dr. and charter president of the the first recipient of the Dean's proach on his ability to mentor in the Department of Psychology Clayson's terrible illness but Association of Professors of Award for Lifetime Achievement students and help them develop at the University. Both will bear grateful for his humanity and Psychology in Medical Schools, in Teaching at Weill Medical both professionally and his name. generosity in making this the first nationwide organiza- College of Cornell University personally." The announcement was made wonderful gift," said Dennis W tion of its kind in the United and the only nonphysician to Since learning of Clayson's by Chancellor Mark S. Wrighton Choi, M.D., Ph.D., head of the States and Canada. He also has receive the Elliot Hochstein illness, Mohler has flown from and William A. Peck, M.D., Department of Neurology. "The been prominent in state and Award, given for distinguished California to visit his former executive vice chancellor for Clayson chair will accelerate the national organizations for teaching by the graduating class teacher once a month. medical affairs and dean of the identification of treatments for psychology professionals and is at Cornell. He also prompted In addition to his many School of Medicine. ALS so that someday others will a consultant at the Memorial the foundation of an honorary other honors, awards and "We are honored that Dr. be spared its ravages." Sloan-Kettering Cancer Center society for junior faculty to prizes, Clayson notes with Clayson's name will be associated He also established a scholar- and the Hospital for Special encourage their commitment pleasure that a former student with Washington University in ship for graduate students in Surgery. to teaching. named his first son after him. "I perpetuity," Wrighton said. "His psychology in appreciation for Based on his own research, "Dr. Clayson taught me that always tell my students they are generous contributions to both his years as a student in the Clayson has written extensively faculty members could indeed be my purpose and my family," the Department of Psychology department. on the psychological effects of approachable and empathetic," he said. and the Department of Neurology "We are very grateful for Dr. demonstrate his lifelong commit- Clayson's contribution," said ment to our University." Henry L. Roediger III, Ph.D., Clayson suffers from amyo- chair of the Department of trophic lateral sclerosis (ALS), or Psychology. "It is satisfying to see Lou Gehrig's disease, a neuro- evidence of the positive experi- muscular disease that usually ences our graduate students have causes death within five years of here. And it is even more diagnosis. "I am impressed by Dr. gratifying to know that such Clayson's enthusiasm and memories inspired Dr. Clayson compassion for others in the face to aid the department's mission of his own devastating illness," of excelling in teaching, research Peck said. "His dedication will and training future leaders in help us recruit and support top our field." faculty, reinforcing our tradition Clayson is emeritus professor of excellence in medical research." at the Weill Medical College of Clayson earned his doctorate Cornell University, where he in psychology from the College of served as a mentor, administra- Nitrous oxide reduces children's pain, anxiety during suturing

BY ANNE ENRIGHT SHEPHERD Luhmann said the method showed fewer side effects such as To young children and their irritability and dizziness and parents, a trip to the emer- reduced recovery time from gency room for stitches can approximately an hour to under mean not only the pain of an five minutes. injury but also anxiety about Children ranging in age from the procedure. 2 to 6 received one of four In a new study, School of different kinds of care: (1) Medicine researchers determined standard care, which included Checking lip Oil health At a recent health fair for the local Chinese community, first-year that nitrous oxide, or laughing comforting and topical anesthesia medical student Peggy Chern takes blood from Hsueh Shih for a cholesterol check. The Asian- gas, is more effective in sedating augmented with injected Pacific American Student Association (APAMSA) sponsors the annual fair, held this year at the lidocaine if needed; (2) standard Chinese Baptist Church in Maryland Heights. APAMSA also sponsors an annual health fair for the young children during facial Vietnamese community. suturing than the more tradi- care and oral midazolam; (3) tional use of an oral pain standard care and nitrous oxide; medication. The study, which or (4) standard care, oral appears in a recent issue of midazolam and nitrous oxide. Gelberman elected president of American Academy of Orthopaedic Surgery Annals of Emergency Medicine, Videotapes of the procedures examined 204 children ages 2 to were blindly scored using the BY JIM DRYDEN from the National Institutes of He has served on the editorial 6. Lacerations requiring sutures Observational Scale of Behavioral Health since 1976 for his research boards of several medical contribute to as many as half of Distress-Revised to assess distress The head of the Department of on dense regular connective publications and is a former emergency department visits by at the beginning of the procedure Orthopaedic Surgery was tissue. He also has research associate editor of the Journal of injured children. and during wound cleaning, elected the new president of the interests in radius fractures, Hand Surgery. He also serves as a "The nitrous oxide worked lidocaine injecting, suturing and American Academy of Ortho- carpal instability and nerve reviewer for the Journal of Bone very well at reducing anxiety in recovery. Doctors inserting paedic Surgery, the largest injuries. and Joint Surgery and the Journal the age group we studied," said sutures, who were blinded to the medical organization of its type He is the author of more than of Orthopaedic Research. Jan D. Luhmann, M.D., assistant method of sedation administered in the world. 200 scientific manuscripts and has He came to the medical professor of pediatrics. "Prior to to their patients, noted adverse Richard H. Gelberman, M.D., received numerous awards for his school in 1995 as the first head this study, nitrous oxide had not effects. Parents also completed the Fred C. Reynolds Professor research, of the then-new Department of been commonly used in questionnaires. and head of orthopaedic surgery, including the Orthopaedic Surgery. Prior to his pediatric emergency units. We Both the parents and physi- became president of the 25,500- Kappa Delta, arrival in St. Louis, Gelberman knew of its widespread and cians said use of standard care member academy March 2 at Nicolas had been a professor of ortho- successful use by dentists in the combined with nitrous oxide was its 68th annual meeting in Andry, paedic surgery at Harvard outpatient setting, so we the highest of all the care San Francisco. Emanuel University Medical School and postulated that it would work methods in reducing pain and He has been a member of the Kaplan, chief of the Hand Surgery well in our setting, too." anxiety. The standard care, oral academy since 1981 and has Sumner Koch Service at Massachusetts When compared to the oral midazolam and nitrous oxide served on more than a dozen of and Marshall General Hospital. pain medication midazolam, method ranked second. its committees and task forces. Urist awards. He received an undergraduate Most recently, he had been one of Gelberman degree from the University of the organization's vice presidents. Gelberman: Hand isaformer North Carolina at Chapel Hill in Mini-Medical School starts March 27 As president, he plans to and wrist surgeon viceDresi. 1965 and a medical degree from initiate a new program designed dent of the American Society for the University of Tennessee in Want to go to medical school addition to some hands-on to improve musculoskeletal care Surgery of the Hand and has Memphis in 1969. Gelberman was but dread the long hours training. Attendees learn for the public through better served on numerous executive an intern at the University of and arduous exams? Here's your operating-room protocol and education for doctors. committees for several national Southern California. He com- chance. Washington University's practice suturing techniques, "We hope to improve care for and international academic pleted his orthopaedic surgery Mini-Medical School is being tour the Genome Sequencing the population, better educate orthopaedic associations. residency at the University of repeated March 27 through May Center and guide minimally orthopaedic surgeons and He is a member of the Wisconsin. He also completed a 15. The eight-week course is invasive surgical instruments improve the efficiency and American Board of Orthopaedic fellowship in hand and micro- open to University supporters, using a miniaturized video effectiveness of orthopaedic Surgery, the American Ortho- vascular surgery at Duke Univer- employees and the general camera. practices," Gelberman said. paedic Association, the Associa- sity Medical Center and a public. It is taught on Tuesdays Information is presented in Gelberman also is chief of tion of Bone and Joint Surgeons, fellowship in pediatric ortho- from 7 to 9 p.m. at the Eric P. an easy-to-understand informal hand and wrist surgery and the Orthopaedic Research Society paedics at Boston Children's Newman Education Center, 320 style, and there are no exams. director of the medical school's and the Academic Orthopaedic Hospital. S. Euclid Ave. Students are able to talk with hand and upper extremity Society. He also is an honorary The American Academy of Enrollment this spring will be faculty after lectures; refresh- fellowship training program. He member of the Mexican Ortho- Orthopaedic Surgeons is an limited to 110 participants. ments are provided. also is orthopaedic surgeon-in- paedic Association, the Canadian organization that provides Medical school professors The fee to attend is $65. For chief at Barnes-Jewish and Orthopaedic Research Society and education programs for ortho- teach the sessions, which include more information or to register, St. Louis Children's hospitals. the Swiss Society for Surgery of paedic surgeons, allied health lectures on various diseases in call 362-9858. Gelberman has had support the Hand. professionals and the public. 4 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS University Events Washington University Opera to perform works by Argento, Menotti

BY LIAM OTTEN Expectations," with libretto by pletely mad, which gives the piece actual ghostly presence, ultimately John Olon-Scrymgeour. As a University Opera a lot of tension. It's a great 30 sparking a tragic confrontation The Washington University young woman, Havisham (sung minutes of high drama, and I with Toby. Opera will stage a pair of by senior Kendra Ford) went mad think that Kendra does it in a way "Baba is another tormented WHO: Jolly Stewart, director; intimate works by two 20th after being abandoned on the that won't let the audience relax character who has lived through John Stewart, conductor century, Italian-American morning of her wedding and has for a second." things that are hard for most of us composers: Dominick Argento's remained tormented ever since. WHAT: "Miss Havisham's Wedding "The Medium" centers on the to understand," Stewart said. "The "Miss Havisham's Wedding Night" True to her famous vow, Night" by Dominick Argento and "The character of Madame Flora (sung central mystery is, after so many and Gian-Carlo Menotti's "The Havisham has never since left her Medium" by Gian-Carlo Menotti by junior Kendall Gladen), a phony seances, what suddenly Medium." rooms nor removed her wedding WHERE: Bixby Gallery in Bixby Hall fraudulent psychic. Baba, as Flora makes her believe that someone The production is sponsored gown; indeed, a decaying wedding also is known, regularly stages from beyond has spoken to her? by the Department of Music in cake sits atop the lace-bedecked WHEN: 8 p.m. March 23 and 24, and seances with the aid of her What makes the tables turn? Arts & Sciences in collaboration table upon which she keeps and at 3 p.m. March 25 daughter Monica (graduate Ultimately, I think it's a question with the School of Art. Perfor- rereads tattered letters from her COST: $7 general seating, $12 table student Elizabeth Hendricks) and the audience has to answer for mances are at 8 p.m. March 23-24 former fiance. seating. Tickets are available at the the mute boy Toby (senior Klaus themselves." and 3 p.m. March 25 in the "It's years later and she's still EdisonTheatre Box Office, 935-6543, Georg). One evening, however, Tickets are $7 for gallery seating University's Bixby Gallery. obsessing," said director Jolly and through MetroTix, 534-1111 while conducting a session with and $12 for table seating. Tickets "Miss Havisham's Wedding Stewart, who founded the clients (sophomore Scott Levin are available at the Edison Theatre Night" is a one-act monodrama Washington University Opera in ties. "The fascinating thing is that and graduate students Kellie Box Office, 935-6543, and through based on the character from 1991 with her husband, John she goes back and forth between Gregg and Christine Johnson), MetroTix, 534-1111, with any Charles Dickens' novel "Great Stewart, director of vocal activi- self-awareness and being com- Baba becomes convinced of an remaining tickets sold at the door. "Black Rain" • Neurotoxicity • Mutant Mice • IT Leadership Skills

"University Events" lists a portion of the Noon. Cell biology and physiology seminar. Todorovic, asst. prof, of anesthesiology and molecular biology div., U. of Glasgow, Reichman, prof, of medicine, preventive activities taking place at Washington "Molecular Regulation of SMC Differentia- of psychiatry. Room 550 Clinical Sciences Scotland. Room 322 Rebstock Hall. medicine and community health, N.J. University March 9-28. Visit the Web for tion During Vascular Development and Research Bldg. 362-8560. 935-7569. Medical School, Newark. East Pavilion expanded calendars for the School of Following Injury." Gary K. Owens, prof., Aud., Barnes-Jewish Hosp. Bldg. 4 p.m. Immunology Research Seminar Medicine (medschool. wustl. edu/events/) assoc. dean and dir. of medical and Ph.D. 362-6904. Wednesday, March 14 Series. "From Mouse to Man? Murine g- and the Hilltop Campus (cf6000.wustl.edu/ programs, molecular physiology and Herpesvirus 68 as a Model of Human g- Noon-1 p.m. Genetics seminar. "Pharma- calendar/events/). biological physics dept., U. of Va. School of 4 p.m. Biochemistry and molecular Herpesvirus Infection." Samuel H. Speck, cogenetics Turning Genetic Polymorphism Medicine, Charlottesville. Room 426 biophysics lecture. Cori lecture. "From prof, of pathology and assoc. prof, of Into Better Therapy." Howard L McLeod, McDonnell Medical Sciences Bldg. Genome Sequences to Protein interac- molecular microbiology. Eric P. Newman core dir. of pharmacology, Alvin J. Siteman 362-2254. tions." David Eisenberg, prof., structural Education Center. 362-2763. Cancer Center, and asst. prof, of medicine. biology and molecular medicine lab., U. of Noon. Friday Forum Luncheon Series. Room 823 McDonnell Medical Sciences Exhibitions Calif., Los Angeles. Cori Aud., 4565 7 p.m. Architecture Monday Night Lecture "Caught by Politics: Art of the 1930s and Bldg. 362-7072. McKinley Ave. 362-0261. Series. Grand Center Housing Competition 1940s." Sabine Eckmann, curator, Gallery lecture. Phillip Durham and Elva Rubio, 4 p.m. Chemistry seminar. The Bayer "Caught By Politics: Art of the 1930s and of Art, and Angela Miller, assoc. prof, of architects, Rubio/Durham Architects, St. Distinguished Leadership. "Surface 1940s." The Gallery of Art. Through March history. Cost: $15 (includes lunch). Gallery Thursday, March 15 Louis, Mo./Chicago, III. Steinberg Hall Patterning and Decoration by Self- 18. Steinberg Hall Aud. 935-4523. of Art. For reservations, call 935-5490. 11 a.m. Pulmonary and Critical Care Grand Aud. (reception 6:30 p.m., Givens Hall). organizing Block Copolymers." Martin "Farewell to Bosnia." Gilles Peress, 4 p.m. Anatomy and neurobiology seminar. Rounds. "The Influence of Regional 935-6293. Moller, prof., U. of Ulm, Germany. Room photographer. The Gallery of Art and the St. "Linking Neuronal Activity and Behavioral Ventilation Distribution on Lung Function." 458 Louderman Hall (recption following at Louis Chapter of the United Nations Assoc. Performance: Some Insights From Studies William A. Altemeier, senior fellow in Tuesday, March 20 5:30 p.m.). 935-6530. Through March 18. Steinberg Hall Aud. of Depth Perception." Gregory C. medicine. East Pavilion Aud., Barnes- 4:15 p.m. Earth and planetary sciences 935-4523. DeAngelis, asst. prof, of anatomy and Jewish Hosp. Bldg. 362-6904. Noon. Molecular Microbiology and colloquium. "RbC104, Oxygen Volumes neurobiology and of biomedical engineer- Microbial Pathogenesis Seminar Series. Noon-1 p.m. Genetics seminar. "Genomic and Core/mantle Interaction." David ing. Room 928 McDonnell Medical "Pyroptosis and the Cellular Immune and Bioinformatic Analysis of Transcription Walker, prof., Lamont-Doherty Earth Sciences Bldg. 362-7043. Response to Salmonella typhimurium." Networks in Yeast." Barak A. Cohen, Observatory, Columbia U. Room 361 Brad T. Cookson, asst. prof, of laboratory genetics dept., Harvard Medical School. McDonnell Hall. 935-5610. Film Monday, March 12 Room 823 McDonnell Medical Sciences medicine and microbiology, U. of Bldg. 362-7072. Washington, Seattle. Cori Aud., 4565 4:30 p.m. Mathematics Kirk Lecture. 4 p.m. Immunology Research Seminar McKinley Ave. 362-2742. "Dirichlet Forms in Holomorphic Function Series. "Molecular Determinants of Tuesday, March 20 12:05-12:55 p.m. Program in Physical Spaces." Leonard Gross, prof., Cornell U. Lymphoid Follicle Structure." David D. Friday, March 16 Therapy seminar. "What Types of Room 199 Cupples I Hall (tea 4 p.m., 6 p.m. Japanese Film Series. "Black Rain." Chaplin, prof, of genetics, of medicine and 9:15 a.m. Pediatric Grand Rounds. Movements Improve in Neurosurgical Room 200). 935-6760. Room 219 Ridgley Hall. 935-5156. assoc. prof, of molecular microbiology. Eric "Functional MRI of Language Develop- Treatment of Parkinson's Disease?" Amy P. Newman Education Center. 362-2763. 5 p.m. Vision Science Seminar Series. 7 p.m. Gallery of Art Film Series. "Scarlet ment." Bradley L. Schlaggar, instr. in Bastian, asst. prof, of program in physical "Myocilin, a Glaucoma-associated Street." Fritz Lang, dir. (1945). Steinberg 4 p.m. Neuroscience Seminar. James neurology and pediatrics. Clopton Aud. therapy and of anatomy and neurobiology. Molecule, in the Optic Nerve." Cynthia Hall Aud. 935-4523. Trimmer, State U. of N.Y., Stony Brook. 4950 Children's Place. 454-6006. Classroom B114, 4444 Forest Park Blvd. Ricard, instr. in ophthalmology and visual Room 928 McDonnell Medical Sciences Noon. Cell biology and physiology seminar. 286-1404. sciences. East Pavilion Aud., Barnes- Bldg. 362-7043. Wednesday, March 21 "On the Selection of Axes of Cell 4 p.m. Anesthesiology research seminar. Jewish Hosp. Bldg. 362-5722. Polarization: Bud-site Selection in Yeast." 6 p.m. Near Eastern Film Series. "Himmo, 5:30 p.m. Mallinckrodt Inst. of Radiology "Mutational Analysis of the Nicotinic 7 p.m. Gallery of Art Lecture Series. King of Jerusalem." Room 219 Ridgley Hall. lecture. Annual Daniel R. Biello memorial John R. Pringle, prof, of biology, U. of N.C., Receptor Binding Site." Gustav Akk, "Berlin Noir: Robert Siodmak's Holly- 935-5156. lecture. "Advances in Molecular Imaging for Chapel Hill. Room 426 McDonnell Medical research instr. in anesthesiology. Room wood." Lutz Koepnick, assoc. prof, of Imaging Gene Expression." Sanjiv S. Sciences Bldg. 747-1808. 5550 Clinical Sciences Research Bldg. German languages and literatures and film Gambhir, assoc. prof, and head of bio- 4 p.m. Neuroscience seminar. "From 362-8560. and media studies. Steinberg Hall Aud. Tuesday, March 27 imaging assay lab, molecular and medical Peppers to Pain: The Molecular Biology of 4 p.m. Chemistry seminar. "Nanowires: 935-4523. pharmacology dept., Crump Inst. for 6 p.m. Chinese Film Series. "Horse Thief." Nociception." David Julius, cellular and Synthesizing the Computer of the Future." Biological Imaging, U. of Calif., Los Room 219 Ridgley Hall. 935-5156. molecular neurobiology dept, U. of Calif., Thomas E. Mallouk, the DuPont Prof, of Angeles. Scarpellino Aud., first floor, 510 S. Friday, March 23 San Francisco. 362-7043. Materials Chemistry, Penn State, Kingshighway Blvd. 362-2866. 9:15 a.m. Pediatric Grand Rounds. "Status University Park, Pa. Room 311 McMillen 7:30 p.m. St. Louis Astronomical Society Epilepticus: Risk Factors, Frequency and Lab. 935-6530. Tuesday, March 13 lecture. "Carbon Stars." Katharina Outcomes." Edwin Trevathan, assoc. prof, Lodders, senior research asst. in earth and of neurology and pediatrics and dir., Lectures Noon. Molecular Microbiology and planetary sciences an the McDonnell Center Wednesday, March 21 Pediatric Epilepsy Center and Pediatric Microbial Pathogenesis Seminar Series. for the Space Sciences. Co-sponsored by 11 a.m. Assembly Series. The Spires and EEG Labs. Clopton Aud., 4950 Children's "The Evolution of Virulence and Antibiotic earth and planetary sciences and NASA's Omicron Delta Kappa Honors Lecture. Place. 454-6006. Resistance in Diarrheal Diseases: Missouri Space Grant Consortium. Room Friday, March 9 Dave Eggers, author of "A Heartbreaking Adventures in the Land of Ooze." Paul 162 McDonnell Hall. 935-4614. 11 a.m. Chemistry seminar. The Bayer Work of Staggering Genius" and editor of 9:15 a.m. Pediatric Grand Rounds. "A Tale Ewald, prof, of biology, Amherst College, Distinguished Leadership. "Structure and McSweeney's, a literary journal. Graham of Three Viruses: Clinically Relevant Mass. Cori Aud., 4565 McKinley Ave. Dynamics of Brush-like Molecules at Monday, March 19 Chapel. 935-5285. Sequence-based Genotyping." Max Q. 747-2630. Surfaces." Martin Moller, prof., U. of Ulm, Arens, research asst. prof.; assoc. dir., 4 p.m. Biology seminar. "Aberrant Gene Noon. Orthopaedic research seminar. Germany. Room 311 McMillen Lab. 4 p.m. Anesthesiology research seminar. 935-6530. clinical virology and co-dir., retrovirus lab. Expression in Tumour Cells Following "Systemic Implications of Total Joint "Neurotoxicity of General Anesthetics in the Clopton Aud., 4950 Children's Place. Inactivation of the Tumour Suppressors RB Replacement." Joshua Jacobs, biochemis- Developing Brain." Vesna Jevtovic 11 a.m. Religious Studies Program 454-6006. and p53." Robert White, biochemistry and try dept., Rush U„ Chicago. Room 11300 lecture. Inaugural Witherspoon Lecture in West Pavilion, Barnes-Jewish Hosp. Bldg. Religion and Science. "Science and/or 454-7800. Religion." Steven Weinberg, physics and Best-selling memoirist Dave Eggers comes to Graham 4 p.m. African Studies Lecture Series. astronomy depts., U. of Texas, Austin. "Black Aesthetics and the Politics of Graham Chapel. 935-7752. Writer Dave Eggers will give an i Eggers now is Representation." Sylvester 0. Ogbechie, Noon. Cell biology and physiology Assembly Series talk at 11 Assembly Series editor of art history and archaeology dept. Co- seminar. "Intercellular Calcium T '"" sponsored by African and Afro-American a.m. March 21 in Graham Chapel. il McSweeney's, a Signalling." Thomas H. Steinberg, assoc. University freshmen are t Studies, Washington LL, and Center for prof, of cell biology and physiology and of Who: Writer Dave Eggers (left) groundbreaking International Studies, U. of Mo., St. Louis. medicine. Room 426 McDonnell Medical familiar with Eggers' tale of a literary journal Room 200F Eliot Hall. 935-5690. Science Bldg. 747-4233. family tragedy from reading his What: Spires and Omicron Delta Kappa that publishes 4 p.m. Chemistry seminar. "The Molecular Honors Lecture 2:30 p.m. Physics seminar. "Form Factors best-selling memoir, "A Heart- esoteric pieces Biochemistry of Quorum Sensing: How for Fluctuations in the Cosmic Background breaking Work of Staggering V ••" Where: Graham Chapel by writers such Bacteria Talk to Each Other." Stephen Radiation." Steven Weinberg, U. of Texas, Genius," for English composition as David Foster Ferrand, chemistry dept., U. of III. Room Austin. Room 204 Crow Hall (refresh- When: 11 a.m. March 21 class. Wallace and 311 McMillen Lab. 935-6530. ments 2:15 p.m.). 935-6276. "Dave Eggers' book was a grand Rick Moody. 4 p.m. Mouse genetics conference. "Using 4 p.m. Anatomy and neurobiology experiment for us," said Amy Pawl, Unusual in its tone and style, Each issue of McSweeney's is Transgenic, Targeted and Insertional seminar. Glenn C. Conroy, prof, of adjunct assistant professor in the Mutant Mice to Analyze Gene Function and anatomy and neurobiology. Room 928 the book has received considerable designed as an individual work of Expression." Jeffrey H. Miner, asst. prof, McDonnell Medical Sciences Bldg. . Department of English in Arts & literary attention. The New York art - issue No. 4, for example, of cell biology and physiology and of 362-7043. Sciences. "We wanted to get the Times' Michiko Kakutani de- consists of 14 individually medicine, renal div. Room 9941 Clinical Sciences Research Bldg. 362-8983. 4:30 p.m. Mathematics colloquium. "A first-year students talking about a scribed Eggers' story as "a designed miniature books Novel Approach to Estimating Hormonal common text; we picked Eggers' virtuosic piece of writing, a big contained in a customized box. 8 p.m. Writing Program Reading Series. Pulse-times and Structural Parameters." memoir because we felt its daring, manic-depressive stew of a Eggers' talk, which is free and Lynne McMahon, poet. Author of "The Somesh Chattopadhyay, U. of Virginia, uncommon combination of book." open to the public, is the Spires House of Entertaining Science," Charlottesville. Room 199 Cupples I Hall "Devolution of the Nude," and "Faith." (tea 4 p.m., Room 200). 935-6760. literary seriousness and pop Before publishing his first and Omicron Delta Kappa Hurst Lounge, Room 201 Duncker Hall. culture playfulness would spark book, Eggers was editor of a San Honors Lecture. For more 935-7130. Monday, March 26 debates on a range of topics, from Francisco magazine called Might, information, call 935-5285 or family dynamics to media culture known for its satiric stunts and visit the Assembly Series Web Thursday, March 22 Noon. School of Law's Inst. for Global to the role of writing in making Legal Studies lecture. Achilleas off-the-wall subject matter. The page (http://wupa.wustl.edu/ 11 a.m. Pulmonary and Critical Care Grand Demetriades, British-educated, Greek sense of the world." magazine folded in 1997, and assembly). Rounds. "Target Practice." Lee B. Cypriot attorney. Co-sponsored by Hellenic record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS March 9, 2001 5 Poet Lynne McMahon to read for Writing Program Sports Poet Lynne McMahon will read reminds us Yorker, The Adantic Monthly, from her work for the that intellect Poetry, APR, Kenyon Review and 20-point win puts scored nine points and dished University's Writing Program and play are the Yale Review, among others. Her seven assists. Reading Series at 8 p.m. March 21 luminous kin." many awards include the Pushcart women in Sweet 16 The Bears finish the season in Hurst Lounge. McMahon Prize and the Best of American The Bears earned a spot in the with a 23-4 record, tying the A book signing follows the is the author of Poetry Prize as well as grants from Sweet 16 with an 87-67 victory school record for wins in a reading and copies of McMahon's three books of the Guggenheim and Ingram- over Wisconsin-Eau Claire on season. works will be available for poetry: "The Merrill foundations. She serves as a March 3 in the second round purchase. House of professor of English at the Univer- of the NCAA Tournament. WU Baseball opens 4-1 "Lynn McMahon is a poet of Entertaining sity of Missouri, Columbia. jumped on Eau Claire early, The baseball team won its first astonishing range and graceful McMahon: To read Science" (1999), The reading is sponsored by pulling ahead 25-3 and four games and opened its daring," said Carl Phillips, here March 21 "Devolution of the Writing Program in Arts & allowing the Blugolds to shoot season with a 4-1 weekend at professor of English in Arts & the Nude" Sciences and is free and open to just 8 percent in the first nine Kelly Field. Four complete-game Sciences and director of the (1993) and "Faith" (1988). Her the public. For more information, minutes. WU extended its lead performances propelled the Writing Program. "Her work poems have appeared in The New call 935-7130. to as much as 26 four minutes Bears to the four wins. Jon Curd into the second half. went the distance in a 6-2 Four Bears scored in double victory over Webster University. figures, led by Tasha Rodgers' On Saturday, the Bears downed Access to Equal Justice focus of law conference game-high 22 points to go with Coe College and Aurora eight rebounds, four assists A federal prisoner whose Susan Rosenberg, whose law and director of clinical University, both by 3-2 scores, and four steals. Sophomore sentence was commuted due 58-year sentence for weapons education, is one of the with Kurt O'Neal and Noah Jennifer Rudis finished with a to the efforts of Jane Aiken, J.D., possession was commuted by organizers of the conference, Valentino picking up the wins. career-high 20 points and 10 professor of law and director of former President Clinton on Jan. which will highlight innovative Damien Janet shut out Aurora, boards. Lindsey Merrill scored the School of Law's Civil Justice 20, will discuss her experiences law school teaching, commu- 7-0, Sunday; but the Bears fell 12 points and Robin Clinic, will be among the and the role attorneys and law nity projects, government 11-4 to Coe in Sunday's finale. Lahargoue had 10. speakers at a law school confer- students played, including programs and technological Dusty Deschamp finished the ence on "Access to Equal Justice." Aiken's and another attorney resources. weekend 10 for 18 with two The conference is set for who handled her clemency case. Topics include legal services Men's hoops out of doubles, four RBIs and four 9 a.m.-5 p.m. March 23 in Co-sponsored by the for underrepresented communi- NCAA Tournament walks to earn University Athletic Anheuser-Busch Hall. It will Association of American Law ties, new skills for public interest Ryan Knuppel hit a long three- Association Player of the Week focus on improving the delivery Schools, the conference will lawyering, the role of pro bono pointer with four ticks left to lift honors. of legal services to under- include presentations by law lawyer networks, and free legal Elmhurst College to a 78-77 win represented individuals in the St. school faculty and staff, St. Louis Internet services. The conference over the Bears men's basketball Track women win Louis region through increased legal services providers, commu- is free and open to the public, team in the second round of the UAA championship partnerships with the law nity and government leaders, but registration is required and NCAA Tournament on March 3 The women's indoor track, led school, community organiza- and Missouri Supreme Court limited to 100 attendees. For in Elmhurst, 111. by UAA records from Sarah tions, legal services programs and Appeals Court judges. Karen more information or to register, The Bears led 77-72 with Springer and Elizabeth Stoll, and the courts. Tokarz, J.D., LL.M., professor of call 935-6419. just under two minutes left, won the University Athletic but Knuppel, who hit eight Association (UAA) Indoor Track three-pointers on the night, and Field Championship on Society of St. Louis. Room 202 Anheuser- 4 p.m. The Seigle Seminar in American connected three times in the Sunday, March 25 March 2-3. The men's team Busch Hall. 935-7988 Culture. "New York's African Burial last 1:38 to lift the Bluejays to Ground: Memorial, Memory and Human finished second, trailing Emory Noon-1 p.m. Work, Families and Public 10:45 a.m. Men's baseball vs. Milwaukee the come-from-behind win. Rights." Michael Blakey, prof, of Policy Brown Bag Seminar Series. School of Engineering. Kelly Field. University by just 21 points. anthropology and anatomy, curator of the Chris Alexander led the "Career Attainments of Women in 935-5220. The NCAA Indoor Track and W. Montague Cobb Human Skeletal Bears with 21 points, seven Science." Donna Ginther, asst. prof, of 1:15 p.m. Men's baseball vs. Illinois Collection and scientific dir., New York Field Championships are today economics. Room 300 Eliot Hall. Wesleyan U., Bloomington. Kelly Field. rebounds and a career-high African Burial Ground Project, Howard U. and Saturday, hosted by the 935-4918. 935-5220. five blocks. Dustin Tylka Ann W. Olin Women's Bldg. Lounge. University of Wisconsin- finished with 16 points, Chris 4 p.m. Assembly Series. The Rabbi 935-5216. Oshkosh. Stoll, Suzi Ramsey and Jeffries had 13 and Jarriot Ferdinand M. Isserman and the Thomas C. Monday, March 26 Todd Bjerkaas all earned bids to Hennings Memorial Lectures. Paul Simon, Rook had 10. Ryan Patton 4 p.m. Women's tennis vs. Webster U. Tao llinois' former senior U.S. senator; dir. of the meet. Tennis Center. 935-5220. Public Policy Inst., Southern III. U., Carbondale, Graham Chapel. 935-5285. < Music Tuesday, March 27 4 p.m. Immunology Research Seminar course. "Refresher Course and Update in Series. "Cellular and Molecular Basis for 2 p.m. Men's baseball vs. Westminster General Surgery." (Continues through Human Immune Response to Porcine Monday, March 19 College, New Wilmington, Pa. Kelly Field. And more... March 24.) Cost: $450 physicians; $375, Xenograft." Thalachallour Mohanakumar, 935-5220. physicians in training, allied health prof, of medicine, of pathology and the professionals (includes luncheons and 8 p.m. Senior honors recital. Music of 3 p.m. Women's Softball vs. Maryville U. Jacqueline and William Maritz Prof, of dinner). The Ritz-Carlton Hotel, St. Louis. Bach, Mozart, Chopin, Prokofiev. Rita Ho, Softball Field. 935-5220. Friday, March 16 surgery. Eric P. Newman Education Center. pianist. Graham Chapel. 935-5581. To register, call 362-6891. 362-2763. 7:30 a.m. Center for the Application of 8 a.m. STD/HIV course. "STD Clinician." Information Technology membership 4 p.m. The Seigel Seminar in American (Continuing Thursdays through April 26.) Thursday, March 22 CAITFocus session. "Developing IT Culture. "Memorial and Memory: Cost: $90. Distance Learning Instructional 8:30 p.m. Holmes Jazz Series. William Leadership Skills." CAIT Offices, 5 N. Struggles for a Usable Past." Robert Technology Center, U. of Mo., St. Louis. To Lenihan Group. Holmes Lounge, Ridgley Jackson. 935-4792. Dallek, author and prof, of history, Boston Worship register, call 747-0294. Hall. 935-5581. U. Sponsored by American Culture Studies. Ann W. Olin Women's Bldg. Tuesday, March 20 Friday, March 23 Lounge. 935-5216. Friday, March 23 Friday, March 9 Noon-1 p.m. Toastmasters event. Demo 9 a.m. Law School conference. "Access to 8 p.m. WU opera. "Miss Havisham's and membership building session. 7 p.m. Architecture Monday Night Lecture 11:15 a.m. Catholic Mass. (Followed by Equal Justice." Anheuser-Busch Hall. To Series. Warren Schwartz, architect, Wedding Night," Dominick Argento, dir., Sponsored by Washington U. meatless soup lunch.) Catholic Student register, call 935-6419. Schwartz-Silver Architects, Inc., Boston. and "The Medium," Gian-Carlo Menotti, Center, 6352 Forsyth Blvd. 935-9191. Toastmasters for Oratorical Readiness Steinberg Hall Aud. (reception 6:30 p.m., dir. (Also March 24, same time; and March (WUTF0R). Room 1140A, 4480 Clayton 1:10 p.m. Muslim Friday prayers. Includes Givens Hall). 935-6293. 25, 3 p.m.) Bixby Gallery, Bixby Hall. For Ave. 935-6001. Monday, March 26 sermon and prayer service. Lambert tickets, call 935-6543. Lounge, Mallinckrodt Student Center. 1p.m. Center for the Application of Tuesday, March 27 935-3543. Thursday, March 22 Information Technology E-commerce Roundtable kickotf. CAIT Offices, 5 N. Noon. Molecular Microbiology and 7:30 a.m. Continuing Medical Education Jackson. 935-4792. Microbial Pathogenesis Seminar Series. Friday, March 16 "Molecular Genetic Analysis of Invasion 11:15 a.m. Catholic Mass. Catholic Student and Intracellular Development in the AIDS Sports Center, 6352 Forsyth Blvd. 935-9191. Opportunist Toxoplasma." John Boothroyd, prof, and co-chair of 1:10 p.m. Muslim Friday prayers. Includes microbiology and immunology, Stanford Thursday, March 15 sermon and prayer service. Lambert U. Cori Aud., 4565 McKinley Ave. Lounge, Mallinckrodt Student Center. 1:30 p.m. Men's baseball vs. Greenville 362-8873. 935-3543. College, III. Kelly Field. 935-5220. 4 p.m. Pain Center seminar. Jon Levine, prof, of oral and maxillofacial surgery, U. Saturday, March 17 Wednesday, March 21 of Calif., San Francisco. Room 5550 10 p.m. Catholic Mass. (Scripture study 9 Clinical Sciences Research Bldg. Noon. Men's baseball vs. Milwaukee School p.m.) Mudd Hall. 935-9191. 362-8560. of Engineering. Kelly Field. 935-5220. 7 p.m. School of Architecture Lecture Thursday, March 22 Series. Danelle Guthrie and Tom Buresch, Sunday, March 18 architects, Guthrie and Buresch Architects, 7 p.m. Lenten/Easter Reflection Series. 11 a.m. Men's baseball vs. Milwaukee "Understanding Suffering and Healing." Los Angeles. Co-sponsored by School of School of Engineering. Kelly Field. Architecture and Grand Center, Inc. Margaret Mary Moore. (Also March 29, 935-5220. Steinberg Hall Aud. (reception 6:30 p.m., April 5 and 19, same time.) Catholic Givens Hall). 935-6200. Student Center, 6352 Forsyth Blvd. Thursday, March 22 935-9191. Wednesday, March 28 12:30 p.m. Men's baseball vs. Illinois College, Jacksonville. Kelly Field. Friday, March 23 11 a.m. Assembly Series. Women's Week 935-5220. Keynote Lecture, bell hooks, author. 11:15 a.m. Catholic Mass. (Followed by Graham Chapel. 935-5285. meatless soup lunch.) Catholic Student Friday, March 23 Center, 6352 Forsyth Blvd. 935-9191. 4 p.m. Biochemistry and molecular biophysics seminar. "Insights Into the 3:30 p.m. Women's and Men's track and 1:10 p.m. Muslim Friday prayers. Includes Physiological Functions of Intracellular field. WU Mini Meet. Bushyhead Track and sermon and prayer service. Lambert Lipid Binding Proteins." Luis B. Agellon, Francis Field. 935-5220. Lounge, Mallinckrodt Student Center. asst. prof, of biochemistry, U. of Alberta, 935-3543. Edmonton, Alberta, Canada. Erlanger Aud., Saturday, March 24 McDonnell Medical Sciences Bldg. Tuesday, March 27 362-0261. 10:45 a.m. Men's baseball vs. Milwaukee GOWning achievement The School of Art's Des Lee Gallery School of Engineering. Kelly Field. 7 p.m. Reconciliation services. Catholic played host March 1 to "Gowns in the Gallery," an up-close 4 p.m. Chemistry seminar. 935-5220. Student Center, 6352 Forsyth Blvd. preview to the school's fully staged Fashion Show in May at the "Oxazaborolidinones as Versatile Chiral 935-9191. Saint Louis Galleria. (Left-right) Judges Bonnie Edmonds and Lewis Acids in Enantiotopic Face Selective 1:15 p.m. Men's baseball vs. Simpson and Group Selective Reactions." Toshiro College, Indianola, Iowa. Kelly Field. Jane Kairuz, co-coordinators of Fashion Show, examine a skirt- Harade, chemistry dept., Kyoto Inst. of 935-5220. Wednesday, March 28 and-jacked combination by junior Sarah Davidzuk, as modeled Technology, Japan. Room 311 McMillen 10 p.m. Reconciliation services. Mudd by sophomore Suzelle Tempero. Lab. 935-6530. Hall. 935-9191. 6 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS

would have big moraines and big round edges like a flowing Ganymede glacier does." — from Page 1 Moreover, the images reveal depressions that resemble volcanic a full kilometer. They're really calderas along the edges of the very much like rift valleys on the bright terrains. On Earth, calderas Earth, and they're repaved with are large, more-or-less circular something pretty smooth. The craters usually caused by the material in the troughs is more collapse of underground lava like terrestrial lava in terms of its reservoirs. fluidity than relatively stiff glacial "The caldera-like features make ice. We can see this material is a pretty good circumstantial case banked up against the edges of for volcanism causing this the walls of the trough and topography," McKinnon said. "We appears to have been pretty fluid, think these particularly bright much more so than solid, albeit terrains were formed by volcan- warm, ice. These features directly ism, which means that most or all support the idea that they were the other bright terrains started created by volcanism." out this way, and became frac- The researchers used tured, or grooved, over time stereoimaging - a method where through tectonic forces." three- dimensional objects are The earliest proposal about reproduced by combining two or Ganymede is that there was water more images of the same subject on the Jovian moon billions of taken from slightly different years ago. An alternate theory Making his point Assistant Attorney General Gregory L. Barnes argues against a retrial for a angles - to reconstruct the proposed that the bright features convicted murderer during a special session of the Missouri Court of Appeals for the Eastern physical topography of were due to glacier ice that District, held Feb. 26 at the School of Law's Bryan Cave Moot Courtroom. Chief Judge Mary Ganymede's terrains. Maps were erupted from Ganymede's mantle. Kathryn Hoff was joined on the bench by three University alumni, Judges William H. Crandall Jr., then generated from the A third theory proposes that Richard B. Teitelman and Kathianne K. Crane. The court periodically holds sessions in law schools stereoimages. Ganymede's rifts were caused by a as part of its educational program. McKinnon says the images process similar to seafloor provide fundamental new spreading seen on Earth. While information about what really crustal spreading could conceiv- McKinnon said. "For this heat, it's happened long ago on Jupiter's ably operate on Ganymede, it like trying to run up a down large satellite and also illuminates cannot account for the smooth lo escalator; you run in place. But if The researchers used an essential mystery about the swaths McKinnon studied. - way the body reworks its older, "In the places we have looked ■ from Page 1 the escalator slows down, meaning stereoimaging, a method the lava eruptions slow down, then where three-dimensional darker material. at, the two edges of the trough you (the heat) can in fact run to One trough extends an simply cannot be matched up," Ph.D. from the University, and the top." objects are reproduced by estimated 900 kilometers, roughly McKinnon said. Paul M. Schenk, Ph.D., of The researchers used combining two or more 600 miles, the Galileo has been Houston's Lunar and Planetary stereoimaging - a method where approximate distance orbiting Jupiter since 1995. Institute, answer this geological three-dimensional objects are images of the same subject between St. Louis and Its 12 scientific experiments conundrum in the February issue reproduced by combining two or taken from slightly New Orleans. have enhanced researchers' of the journal Geology. The paper more images of the same subject different angles. "The long trough understanding of Jupiter's is called "Chaos on lo: A model taken from slightiy different is probably a billion atmosphere, large moons for formation of mountain blocks angles - to reconstruct the years old, but it's and vast magnetic field. It by crustal heating, melting, and physical topography of much of actually one of the carried the first atmo- tilting." The work was funded by Io's surface. Maps of all the course, volcanoes are notoriously younger volcanic spheric probe to enter NASA's Planetary Geology and mountains and volcanoes on Io's unstable, so if volcanism falters in features," McKinnon Jupiter's atmosphere. one region, the surrounding crust Geophysics and Jovian Systems surface were also made. said. "It's the last gasp McKinnon: Jupiter In other firsts, it was the Data Analysis programs. "The stereo data and high- begins to heat. This causes the of the process that moons researcher first mission to discover a "Two things work in concert resolution pictures taken by the crust to expand, generating made the bright satellite of an asteroid (Ida's to produce Io's mountains," ongoing Galileo mission allowed compressive thermal stress, which terrain." satellite Dactyl); the first to go McKinnon said. "These are us and others to confirm that Io's in turn forces the crust apart, According to McKinnon, the into orbit around Jupiter; the first compressive stress, due to the mountains were indeed tilted forming faults and mountains. geological explanation for such to make a close flyby of an general movement or sinking of fault blocks and not volcanoes," This helps explain why long lanes of flatness is that they asteroid (Gaspra); and the first to the crust closer to Io's center, and McKinnon said. "You can see concentrations of mountains are occurred by the extending and provide direct observations of a thermal stress, which is generated sequences of mountains in early, seen on lo that are separated from opening up of Ganymede's crust. comet hitting a planet (Shoe- when regions of cool crust middle and late stages of collapse; concentrations of volcanoes. The And then that portion of the maker-Levy 9). suddenly become heated." first tall and steep with researchers propose that similar crust became flooded with some Galileo has also provided The combination of compres- landsliding, then intermediate, events may have occurred on sort of lava. extensive information about active sive and thermal stresses breaks up and then basically flat." Europa, another satellite of The high-resolution Galileo volcanism on the moon lo and the the crust and produces irregular, Working out the irregular and Jupiter, and on the early Earth. images show that material that possibility of a subsurface ocean or chaotic, distributions of chaotic distribution of the "Even though the moons have flooded the lanes is "no less liquid on the moon Europa. Later this mountain peaks. Slight changes in mountain peaks - which is quite different surfaces - Europa is ice; than a slush," McKinnon said. year, it will make close approaches the rate of lava flow from Io's different from the linear or lo, rock - they have common "But it is not glacial ice, which to the moons Callisto and lo. mantle and the heating of cooler arcuate patterns found on Earth - geological phenomena," McKinnon crust below the surface create the allowed the researchers to said. "This combination of thermal mountain-forming faults. propose that Io's mountains are and compressive stresses could "Heat is actually trying to come the result of natural disturbances operate in other situations where a that the "rapidly changing out from deep in the interior of lo, in the surface crust. body gets a lot of heat. The early Law program landscape of both law and but the crust is subsiding, or Io's lava makes it to the Earth was very hot, and therefore ■ from Page 2 technology require any lawyer — sinking, as new layers of lava are surface and normally radiates its could have been more like lo in whether IP specialist or not — to laid down, all on the order of one heat into space - lo has no terms of tectonics and volcanism thriving center of biotechnology, maintain up-to-date training. to several centimeters a year," atmosphere to speak of. Of than the Earth today." McManis said. "An LL.M. in intellectual At the same time, foreign property law from Washington countries are adopting patent and University will not only help the trademark protections at unprec- savvy IP specialist to proudly edented levels, creating a demand display newly minted ability with Employment for lawyers who understand cutting-edge issues, but also will international aspects of the field. help the general lawyer better Use the World Wide Web to obtain complete job descriptions. Go to https://hr.wustl.edu/ (Hilltop) or http://medlcine.wustl.edu/wumshr (Medical). The intellectual property program advise clients about the latest will augment the school's already trends impacting the most Senior Medical Director, Human Associate Director, Receptionist 010256 Office of Human Sciences Writer highly respected advanced degree significant portion of the asset Hilltop Resources and Annual Giving Department Resources at Payroll 010201 Programs 010231 010108 Secretary 010258 362-7196. External training in U.S. law for interna- base for most clients," Kieff said. Campus Mechanic Application Senior Prospect candidates: Submit Administrative tional students, Ellis said. For more information on the (Bargaining Unit Processor II010202 Researcher 010236 resumes to the Office Information regarding Assistant I 010259 Kieff, who has extensive new program or the April 6-7 Employee) 010111-2 of Human Resources, positions may be Assistant Football Application Administrative 4480 Clayton Ave., experience practicing in the field conference, visit the law school's obtained in tbe Office of Appointment Coach 010203 Processor II010238 Assistant II010261 Campus Box 8002, Human Resources, Coordinator 010128 St. Louis, MO 63110, of intellectual property law, noted Web site at http://ls.wustl.edu. < Room 130, West Administrative Reference/Subject Program Coordinator Research Assistant or call 362-7196. Campus. If you are not Assistant 010209 Librarian Assistant 010262 010140 (Psychology) 010241 a WU staff member, call Project Manager Statistical Data Assistant Accountant Analyst 010553 935-9836. Staff Coordinator, 010210 Reference/Subject 010263 members call 935-5906. Programming and All Librarian (German) Senior Prospect Secretary III 010773 Campus Events Customer Service Research Technician Researcher 010213 010242 Representative/ Research Patient 000256 010146 Weekend/Evening Customer Specialist/ Receptionist 010264 Coordinator 010883 Director 010149 Manager/Circulation Campus Watch Sr. Research Project Coordinator Police Service Aide Payroll Assistant Assistant/Jr. Assistant 010243 Financial Aid 010218 010265 010981 Research Associate Coordinator 010155 Lab Technician Coordinator, Alumni 000297 & Student Marketing Receptionist/ Animal Care Catalog Librarian 010220 The following incidents were reported to University Police March 1-5. Readers with & Relations 010245 Secretary 010266 Technician Research Assistant 010166 Network Engineer (weekends only) information that could assist in investigating these incidents are urged to call 935-5555. This 000341 Administrative Research Assistant 011008 information is provided as a public service to promote safety awareness and is available on Lan Engineer 010171 010222 010268 General Services Secretary (part time) the University Police Web site at rescomp.wustl.edu/-wupd. Assistant Facility Phone Operator 010246 Research Technician Assistant 000377 Administrative Aide I (part time) 011152 Manager 010179 010223 010270 Research Assistant Administrative Aide Zone Manager Administrative 010247 Senior Departmental 010023 Shuttle Coordinator Accounting Assistant 010182 Assistant 010225 010272 March 5 area for evidence and witnesses Administrative Assistant General 011192 Director of MBA Assistant Director for was unsuccessful. Total loss was Secretary 010032 Counsel 010248 Deputized Police Student Services SIS Services and Business Manager 12:55 p.m.— A University Administrative Officer 010273 valued at $6,000. Instructional 010184 Training 010226 011232 employee stated that between Technology Specialist Coordinator 010249 Planned Giving Associate Director of Medical Secretary II University Police also responded 010033 Research Technician 8:45 a.m. and 12:45 p.m. an Officer 010194 Foundation Medical (part time) 011275 to four additional reports of theft, Director of 010250 unknown person stole her Administrative Aide Relations 010227 Medical Assistant II Admissions and three reports of vandalism, one 010197 Director of Residential College Campus 011279 vehicle that was parked behind Marketing 010069 Director 010251-53 report of leaving the scene of an Career Services Operations, This is a partial list of the Stix International House. Associate Director of Information Executive Programs Administrative positions at the School automobile accident and one Research All doors to the vehicle had Coordinator 010198 010228 Assistant 010254 of Medicine. report of disturbing the peace. Communications Employees: Contact been locked. A search of the Communications Senior Compliance ECS/FWS Awards 010107 the medical school's Technician 1010199 Auditor 010229-30 Processor 010255 record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS March 9, 2001 7 Notables

Ph.D., professor of otolaryngol- ogy, and Joel A. Goebel, M.D., Of note associate professor of otolaryn- Carole L. Wilson, Ph.D., research gology in the School of Medicine, assistant professor of pediatrics in received a one-year, $15,000 the School of Medicine, received a grant from the National Science two-year, $462,750 grant from the Foundation for a research National Institute of Dental and conference titled "The Vestibular Craniofacial Research for a research Labyrinth in Health and Disease project titled "Modulation of Beta- Conference." ... Defensins by Matrilysin." ... Aaron DiAntonio, Ph.D., Master of social work student assistant professor of molecular Jenny Brav and about 20 class- biology and pharmacology in the mates in a "Organizing, Coalition School of Medicine, received a Building and Lobbying" course will three-year, $225,000 grant from be heading to Jefferson City at 5:30 the Whitehall Foundation for a.m. March 13 to lobby members of research titled "Regulated the Missouri legislature on bills Proteolysis and the Control of related to elder abuse, public Synaptic Growth." ... housing and the establishment of a Michael Brent, Ph.D., prisoner ombudsman. The George associate professor of computer Warren Brown School of Social science, received a two-year, Work students are looking for $150,000 grant from the National members of the campus commu- Science Foundation for research nity to join them in their efforts. titled "Complete Gene Structure John Robertson, Ph.D., visiting Prediction." ... professor of social work, teaches the Washington University has course, which includes the Lobby received a National Institutes of Day effort supported by the Health, grant to support summer Missouri Association for Social undergraduate research fellow- Welfare. For more information, ships for 10 students majoring in contact Brav at jvbl@gwbmail. engineering, math, physics or other physical sciences. The four- NASA teams With University Students Nathan Bayless, junior mechanical engineering wustl.edu.... student in the University's Dual Degree program, works with a Compton-Drew Middle School Arthur H. Neufeld, Ph.D., the year, $325,000 grant will allow students to participate in student at the St. Louis Science Center. Bayless was one of seven School of Engineering and Bernard Becker Research Professor Applied Science students who worked with middle school children on an interactive Web site that of Opthamology and Visual biomedical research with selected taught them about electricity and magnetism. The University students were involved in a NASA Sciences in the School of Medicine, mentors in biology, biomedical video featuring the middle school students. The video, "Patterns, Functions and Algebra: Wired for received a one-year, $47,075 grant engineering, chemistry, bio- Space," is part of a NASA series, NASA CONNECT, free instructional TV programs delivered to from Horncrest Foundation Inc., chemistry and molecular classrooms via satellite. NASCAR racing champion Jeff Gordon made a guest appearance on the for research titled "Demonstration biophysics, cell biology and program, demonstrating how important math, science and engineering is to racing. The film was of Pharmacological physiology, surgery, genetics and shown March 2 to students at Compton-Drew Middle School. Neuroprotection in a Glaucoma medicine.... Model Using Old Rats." ... Mary-Jean Co well, Ph.D., Wu Ling-Gang, Ph.D., assistant associate professor of performing professor of anesthesiology in the arts in Arts & Sciences, has been School of Medicine, received a one- elected to a three-year term on year, $120,676 grant from the the National Board of the Obituaries National Science Foundation for American College Dance Festival research titled "Regulation of the Association and to a two-year Kinetics of Vesicle Endocytosis in a term as vice-president of the Enrique Higa, 61 Central Synapse."... Missouri Dance Educators Organization. Enrique Higa, M.D., former Stephen M. Highstein, M.D., Margaret J. Sigelnski, 62 associate professor of Margaret J. Sigelnski, Mo.; daughter, Denise Wanser pathology at the School of department secretary in of Florida; mother, Josephine Medicine, died Monday, Feb. 19, Nobel Prize winner to give Witherspoon Lecture residential life, died Sunday, R. Brandt of East Alton, 111.; 2001, of cancer at his home in Feb. 4, 2001, at Barnes-Jewish brother, John Brandt of Wood Chesterfield, Mo. He was 61. on elementary particle physics, Nobel Laureate Steven Weinberg Hospital after complications River, 111., five sisters, will present "Science and/or cosmology and other subjects. from a blood clot. She was 62. Josephine Nagele of Religion," the inaugural Weinberg was educated at Sigelnski had worked for Theodosia, Mo., Joan Walton Raymond Gerfen, 33 Cornell, Copenhagen and Witherspoon Lecture in Religion the University for 17 years. of Cottage Hills, 111., June and Science, at 11 a.m. March 23 Princeton universities. He has Raymond W Gerfen, former She is survived by her Brandt of East Alton, 111., Joyce medical research technologist in Graham Chapel. taught at Columbia, Berkeley and husband, William J. Sigelnski; Livingston of Piedmont, Mo., Weinberg is the Josey Regental Harvard universities and also at in neurology and neurosurgery at four sons, Robert Leporin of and Jenny Tumbus of St. the School of Medicine, died Chair of Science and professor in Massachusetts Institute of St. Louis, Steven Leporin of Louis; and 19 grandchildren. the physics and astronomy Technology. Saturday, Feb. 24,2001, after Texas, Dennis Leporin of Funeral services were held being struck by lightning at his departments the University of The Witherspoon Lecture Series Cahokia, 111., and Michael Feb. 6 at Braun Colonial Texas, Austin. His research has farm in St. Clair County. He was made possible by a grant in Leporin of House Springs, Funeral Home in Cahokia. spanned a broad range of topics in 2000 from William Witherspoon, a was 33. quantum field theory, elemental retired investment banker and a particle physics and cosmology. past student and teacher at Weinberg was awarded the 1979 University College. His gift was several organs, including the "This is exciting because Nobel Prize in physics and the 1991 motivated by a deep interest in brain. But its role in nerve-cell very few molecules are known National Medal of Science. both science and religion. Protein damage was unclear. So the to influence the necrotic He holds honorary doctorates The lecture is sponsored by Study uncovers new researchers determined how mice component of cell death," from 12 universities and has the religious studies program and lacking clusterin react to brain Holtzman said. "Either authored more than 200 articles is free and open to the public. contributor to brain damage injury. clusterin contributes to a new — from Page 1 The mice suffered roughly half pathway that's neither necrotic as much brain injury as mice that nor apoptotic, or it actually Necrosis might account for the were able to make clusterin. contributes to necrosis." other half of brain injury after "We thought clusterin might Having shown that clusterin prenatal or perinatal brain trauma. help protect cells against injury," plays a critical role in neonatal It also might account for most of Holtzman said. "But apparently, it brain injury, Holtzman and his the cell death after adult brain actually contributes to cell death." colleagues hope to determine injury. But because scientists have Two observations made the whether the protein also not identified all the key compo- researchers conclude that becomes involved after other nents of the necrosis pathway, it clusterin is not involved in forms of acute nervous system has been difficult to __ _ injury such as stroke intervene to prevent or spinal cord injury it from killing cells. 'This is exciting because very few molecules as well as in To identify the neurodegenerative main factors that are known to influence the necrotic diseases such as contribute to the component of cell death. Either clusterin Alzheimer's disease. aftereffects of "If the implica- decreased oxygen contributes to a new pathway that's neither tions of this paper and blood flow to necrotic nor apoptotic, or it actually are correct, we the brain in new- predict that borns, Holtzman's contributes to necrosis." clusterin will play a team first examined DAVID M. HOLTZMAN, M.D. role in brain injury a mouse model of models that include A Champion for the aits Henry I. Schvey, Ph.D., chair of the Performing Arts Department (PAD) in Arts & Sciences, congratu- cerebral palsy that some form of lates Annelise Mertz, professor emerita in the PAD'S Dance mimics the effects of H-I injury. apoptosis. First, the lack of caspase-independent injury, Program, on the dedication of the Annelise Mertz Dance Studio in They found that an enzyme called clusterin in the genetically altered such as necrosis," Holtzman Mallinckrodt Center at a ceremony Sunday. The naming — which caspase-3 became highly active in mice failed to affect caspase-3 said. "We also think that if you honors Mertz's achievements as a teacher, performer and chore- the brain cells of these mice, activity. Second, the brain cells block both clusterin and ographer, and champion for the arts — was made possible by the indicating the onset of apoptosis. that accumulated clusterin and caspase-3 effects, you will have generosity of Dr. Morris D. Marcus, a dermatologist and professor But some of the dying brain cells the cells with activated caspase-3 an additive effect. Modifying emeritus at the University's School of Medicine, in memory of his had large amounts of clusterin. did not overlap — cells had the clusterin pathway may late wife, Margaret Marcus, a former student of Mertz's. Clusterin was known to clusterin or caspase-3 but therefore be a new target for accumulate during cell death in not both. developing therapies." 8 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS record.wustl.edu Washington People

Bruce Backus and his staff draw most attention when, laden with equipment, they're rushing down a corridor to the scene of a chemical spill or an emergency indoor air quality response. But dealing with emergencies is a small part of the Environmental Health and Safety Office's (EHS) job. Most of the 200 calls and e-mails that come in on an average day are more mundane — questions about complying with government regulations or requests for hazardous-waste pickup. Backus, the director of EHS in the School of Medicine, wants his staff of 32 to stay in close touch with labs because he believes that cooperation is the way to avoid violations and accidents. "We're not the police," Backus said. "We're partners with the researchers." The faculty welcomes this approach. "Providing a safe working environment is the right thing to do, and Bruce Bruce Backus (center), director of environmental health and safety, instructs occupational and health helps us do it. He is knowledge- technologists Maria Thomas (left) and Brad King during a mock cleanup in a lab environment. Thomas able and practical, a rare and King are wearing full face respirators; Backus is holding an air quality monitor. disposal of this waste, which are rigorously enforced. Inspectors from the Environ- Backstopping researchers' safety mental Protection Agency (EPA) and the Missouri Department of Natural Resources may make an combination," said James R. mental problems," Backus said. and Backus has members of his unannounced visit any time, and Bruce Backus Schreiber, M.D., the Elaine and His employer supported staff on duty around the clock. they typically begin by checking Mitchell Yanow Professor of Backus' pursuing a master's degree They have dealt with chemical trash cans, sewer drains and handles everything Obstetrics and Gynecology. in chemical engineering while he spills, radioactive material spills and loading docks for dumping. If Backus' interest in medicine continued to work full-time. After even a fire in an operating room. In they don't find any - they never from routine can be traced to his father, a graduation, Backus was undecided addition to acting as liaison have at the medical school - they pediatric neurologist. He was as to whether go into biotechnol- between University protective go to Backus' office and announce questions to serving in the Navy at the time ogy or the environmental field. services and city emergency that they are going to inspect labs. of Backus' birth, and the family The opportunity to work with Fay workers, they often go to the scene Backus and his staff see to it earthquake and traveled with him to such Thompson, Ph.D., CIH, a leader in to clear the area or help the injured. that the labs are always ready. faraway postings as Taipei. the environmental health and At the scene of a chemical spill, they They hold regular training flood plans "There are pictures of me safety field, led him down the may put on "moon suits" to sessions with lab workers and do toddling down a dirt road with a environmental path. perform a cleanup. inspections of their own, pointing water buffalo in the background, In 1988, he joined Thompson Calls complaining about an out potential trouble spots, but I was too young to remem- making sure paperwork is in ber any of it," Backus said with order and checking labels on BY DAVID LINZEE a smile. bottles of chemicals for accuracy. When his father left the "Bruce is an enormously talented environmental health Mistakes have brought fines of service, the family returned to and safety professional. The Washington University $1,000 per bottle at other the United States, settling first in School of Medicine is fortunate to have him leading its universities. Illinois, then in Minnesota. In his rare quiet moments, Like many boys growing up environmental health and safety program." Backus gets to sit back and in the 1960s, Backus followed EMMETT BARKLEY contemplate disaster. He is the the space race avidly and built medical school's point man for telescopes and model rockets. figuring out what to do in the event "I liked to try to figure out at the Department of Environ- odor may not seem as dramatic, of a bioterrorism strike, earthquake, how things worked," he said. mental Health and Safety at the but Backus takes any threat to flood or other calamity. Once he took apart his father's University of Minnesota, which indoor air quality seriously. "We have plans in place," he pocket watch. "Unfortunately, was responsible for all five "First we want to know what's said. "Our priority is to support there were a few pieces left over university campuses. Ten years causing the odor and is it a the hospitals, but we must also Bruce 0. Backus after I put it back together," he later, he came to Washington health hazard," Backus said. ensure the safety of medical noted dryly. University's medical school. "Then we find out where it's school people and protection of Chemistry and biology were His work here has won high coming from." our research and teaching Born: Oakland, Calif. his favorite subjects in high praise from fellow administrators. To answer the first question, programs." University position: Director, school, and he majored in "Bruce has a unique ability to EHS staffers use not just their Backus and his family live in Environmental Health and Safety chemistry at college. After discern the needs of faculty, noses but an array of monitoring Kirkwood. His wife, Liz, a former Office in the School of Medicine earning a bachelor's degree, understand the regulatory issues equipment,.including devices real estate analyst, has a journalism Backus went to work in agricul- and deploy his staff and resources that can identify particular degree. Currently, she is a volunteer Education: B.A., Chemistry, tural engineering. Dealing with to provide a safe, healthy environ- chemicals in the air. Tracking the teacher and an activities leader at Macalester College; M.S., Chemical wastewater caused him to think ment," said Denise A. McCartney, smell to its source often calls for church and schools their three Engineering, University of Minnesota, about the dangers of pollution in associate vice chancellor for old-fashioned detective work. children attend. On weekends, the Twin Cities Campus a crowded world. research. In one case, reports of a smell family enjoys outings to such Family: Wife Liz; children Will, 10, "The increase in population Walter W. Davis Jr., assistant of gas in one lab had EHS destinations as the Magic House John, 8, Carolyn, 3 and the waste we generate is the dean and chief facilities officer, workers looking all over the and Elephant Rock State Park. The basis of many of our environ- said, "Bruce is establishing, plumbing chases and into Backus children are also fascinated without question, one of the basement tunnels, and they with model rockets, like dad. premier environmental health and finally found a gas pipe that a His scientific curiosity, which safety programs in the nation, if contractor had cut and failed to has widened with the years, serves not the world." reseal. Other cases have called for him well in a job that calls for This sentiment is echoed by diplomacy rather than detective him to grasp many diverse Bpt^iJlJ Bj experts outside the University. work. When a lab complains research projects. >~ "Bruce is an enormously about fumes coming from "Bruce was one of the first talented environmental health and construction work, or one lab people here to see the experimen- ik* safety professional," said Emmett complains about the chemicals tal and clinical potential of our •UP