Claire Voisin
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Unrestricted Immigration and the Foreign Dominance Of
Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of -
FIELDS MEDAL for Mathematical Efforts R
Recognizing the Real and the Potential: FIELDS MEDAL for Mathematical Efforts R Fields Medal recipients since inception Year Winners 1936 Lars Valerian Ahlfors (Harvard University) (April 18, 1907 – October 11, 1996) Jesse Douglas (Massachusetts Institute of Technology) (July 3, 1897 – September 7, 1965) 1950 Atle Selberg (Institute for Advanced Study, Princeton) (June 14, 1917 – August 6, 2007) 1954 Kunihiko Kodaira (Princeton University) (March 16, 1915 – July 26, 1997) 1962 John Willard Milnor (Princeton University) (born February 20, 1931) The Fields Medal 1966 Paul Joseph Cohen (Stanford University) (April 2, 1934 – March 23, 2007) Stephen Smale (University of California, Berkeley) (born July 15, 1930) is awarded 1970 Heisuke Hironaka (Harvard University) (born April 9, 1931) every four years 1974 David Bryant Mumford (Harvard University) (born June 11, 1937) 1978 Charles Louis Fefferman (Princeton University) (born April 18, 1949) on the occasion of the Daniel G. Quillen (Massachusetts Institute of Technology) (June 22, 1940 – April 30, 2011) International Congress 1982 William P. Thurston (Princeton University) (October 30, 1946 – August 21, 2012) Shing-Tung Yau (Institute for Advanced Study, Princeton) (born April 4, 1949) of Mathematicians 1986 Gerd Faltings (Princeton University) (born July 28, 1954) to recognize Michael Freedman (University of California, San Diego) (born April 21, 1951) 1990 Vaughan Jones (University of California, Berkeley) (born December 31, 1952) outstanding Edward Witten (Institute for Advanced Study, -
Institut Des Hautes Ét Udes Scientifiques
InstItut des Hautes É t u d e s scIentIfIques A foundation in the public interest since 1981 2 | IHES IHES | 3 Contents A VISIONARY PROJECT, FOR EXCELLENCE IN SCIENCE P. 5 Editorial P. 6 Founder P. 7 Permanent professors A MODERN-DAY THELEMA FOR A GLOBAL SCIENTIFIC COMMUNITY P. 8 Research P. 9 Visitors P. 10 Events P. 11 International INDEPENDENCE AND FREEDOM, THE INSTITUTE’S TWO OPERATIONAL PILLARS P. 12 Finance P. 13 Governance P. 14 Members P. 15 Tax benefits The Marilyn and James Simons Conference Center The aim of the Foundation known as ‘Institut des Hautes Études Scientifiques’ is to enable and encourage theoretical scientific research (…). [Its] activity consists mainly in providing the Institute’s professors and researchers, both permanent and invited, with the resources required to undertake disinterested IHES February 2016 Content: IHES Communication Department – Translation: Hélène Wilkinson – Design: blossom-creation.com research. Photo Credits: Valérie Touchant-Landais / IHES, Marie-Claude Vergne / IHES – Cover: unigma All rights reserved Extract from the statutes of the Institut des Hautes Études Scientifiques, 1958. 4 | IHES IHES | 5 A visionary project, for excellence in science Editorial Emmanuel Ullmo, Mathematician, IHES Director A single scientific program: curiosity. A single selection criterion: excellence. The Institut des Hautes Études Scientifiques is an international mathematics and theoretical physics research center. Free of teaching duties and administrative tasks, its professors and visitors undertake research in complete independence and total freedom, at the highest international level. Ever since it was created, IHES has cultivated interdisciplinarity. The constant dialogue between mathematicians and theoretical physicists has led to particularly rich interactions. -
Summer 2020 Re Visiting a Past Event
REINVENTING AMERICAN DEMOCRACY FOR THE 21ST CENTURY THE INTERSECTION OF DEMOCRACY & RELIGION A Nation in Crisis SUMMER 2020 RE VISITING A PAST EVENT Policy Perspectives on Police Use of Lethal Force As America reckons with its relationship to police violence, we are reminded that progress can be slow. It has been more than five years since the deaths of Michael Brown and Eric Garner. On February 4, 2015, the Academy convened a discussion at the University of California, Berkeley, led by Andrea Roth (Assistant Professor of Law, University of California, Berkeley School of Law) and Franklin Zimring (William G. Simon Professor of Law, University of California, Berkeley School of Law) about the hundreds of people who are killed each year by police, the racial disparity among the victims, and the incomplete data that make analyzing the problem so difficult. The conversation also covered the effectiveness of various avenues for police reform. To read the full transcript of this event (published in the Spring 2015 issue of the Bulletin) and hundreds of other Stated Meetings from the last twenty years, please visit amacad.org/bulletin. A video of this event and many others can be found at youtube.com/americanacad. For more information about Academy events, please visit www.amacad.org/events. SUMMER 2020 CONTENTS Features 16 Letters from Members Letters upon election are an Academy tradition. Letters of reflection are something new. 20 Online Discussions A series of virtual programs on topics related to the COVID-19 pandemic. CONTENTS 4 Our Work 4 Reinventing American Democracy for the 21st Century 9 New Issue of Dædalus Explores the Intersection of Democracy & Religion 12 A New Profile of Humanities Departments Members 25 Noteworthy 9 Departments 3 From the President 28 From the Archives ON THE COVER: Several hundred doctors, nurses, and medical professionals gathered on June 5, 2020, in St. -
Investigating Cosmic Snowballs
Investigating Cosmic Snowballs Professor David Jewitt CREDIT: NASA INVESTIGATING COSMIC SNOWBALLS Professor David Jewitt and his team at UCLA explore the nature of comets. These fleeting visitors to our cosmic shore are important sources of information, and can help to reveal the origin and evolution of the solar system. Most recently, Professor Jewitt’s team have explained the unusual activity of some of the most distant comets in the solar system. Comets play a vivid historical role in the orbital periods of less than 200 years), human psyche, often being interpreted and the other supplying long-period as portents of impending doom. In the objects (greater than 200 years). The era of modern science, we realise that nearest store of cometary precursors, comets are simply icy leftovers, frozen in containing billions of nuclei larger time since the solar system’s formation than a kilometre across, is called the about 4.6 billion years ago. Kuiper Belt. This is a fat disk of objects encircling the Sun with an inner edge Far from bringing us doom and disaster, at Neptune’s orbit – approximately 7.5 comets offer scientists unparalleled billion kilometres from the Sun, or 30 opportunities to learn about the earliest AU – and reaching out to at least several periods of the solar system’s evolution. thousand AU. Pluto resides in this region At the same time, they are some of and is now recognised as large Kuiper the most challenging objects to Belt object. study and remain some of the least well understood. The Kuiper belt was discovered by Professor David Jewitt and his former What Are Comets and Where Do student Jane Luu in 1992. -
Twenty Female Mathematicians Hollis Williams
Twenty Female Mathematicians Hollis Williams Acknowledgements The author would like to thank Alba Carballo González for support and encouragement. 1 Table of Contents Sofia Kovalevskaya ................................................................................................................................. 4 Emmy Noether ..................................................................................................................................... 16 Mary Cartwright ................................................................................................................................... 26 Julia Robinson ....................................................................................................................................... 36 Olga Ladyzhenskaya ............................................................................................................................. 46 Yvonne Choquet-Bruhat ....................................................................................................................... 56 Olga Oleinik .......................................................................................................................................... 67 Charlotte Fischer .................................................................................................................................. 77 Karen Uhlenbeck .................................................................................................................................. 87 Krystyna Kuperberg ............................................................................................................................. -
Comments on the 2011 Shaw Prize in Mathematical Sciences - - an Analysis of Collectively Formed Errors in Physics by C
Global Journal of Science Frontier Research Physics and Space Science Volume 12 Issue 4 Version 1.0 June 2012 Type : Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA) Online ISSN: 2249-4626 & Print ISSN: 0975-5896 Comments on the 2011 Shaw Prize in Mathematical Sciences - - An Analysis of Collectively Formed Errors in Physics By C. Y. Lo Applied and Pure Research Institute, Nashua, NH Abstract - The 2011 Shaw Prize in mathematical sciences is shared by Richard S. Hamilton and D. Christodoulou. However, the work of Christodoulou on general relativity is based on obscure errors that implicitly assumed essentially what is to be proved, and thus gives misleading results. The problem of Einstein’s equation was discovered by Gullstrand of the 1921 Nobel Committee. In 1955, Gullstrand is proven correct. The fundamental errors of Christodoulou were due to his failure to distinguish the difference between mathematics and physics. His subsequent errors in mathematics and physics were accepted since judgments were based not on scientific evidence as Galileo advocates, but on earlier incorrect speculations. Nevertheless, the Committee for the Nobel Prize in Physics was also misled as shown in their 1993 press release. Here, his errors are identified as related to accumulated mistakes in the field, and are illustrated with examples understandable at the undergraduate level. Another main problem is that many theorists failed to understand the principle of causality adequately. It is unprecedented to award a prize for mathematical errors. Keywords : Nobel Prize; general relativity; Einstein equation, Riemannian Space; the non- existence of dynamic solution; Galileo. GJSFR-A Classification : 04.20.-q, 04.20.Cv Comments on the 2011 Shaw Prize in Mathematical Sciences -- An Analysis of Collectively Formed Errors in Physics Strictly as per the compliance and regulations of : © 2012. -
Section 1: MIT Facts and History
1 MIT Facts and History Economic Information 9 Technology Licensing Office 9 People 9 Students 10 Undergraduate Students 11 Graduate Students 12 Degrees 13 Alumni 13 Postdoctoral Appointments 14 Faculty and Staff 15 Awards and Honors of Current Faculty and Staff 16 Awards Highlights 17 Fields of Study 18 Research Laboratories, Centers, and Programs 19 Academic and Research Affiliations 20 Education Highlights 23 Research Highlights 26 7 MIT Facts and History The Massachusetts Institute of Technology is one nologies for artificial limbs, and the magnetic core of the world’s preeminent research universities, memory that enabled the development of digital dedicated to advancing knowledge and educating computers. Exciting areas of research and education students in science, technology, and other areas of today include neuroscience and the study of the scholarship that will best serve the nation and the brain and mind, bioengineering, energy, the envi- world. It is known for rigorous academic programs, ronment and sustainable development, informa- cutting-edge research, a diverse campus commu- tion sciences and technology, new media, financial nity, and its long-standing commitment to working technology, and entrepreneurship. with the public and private sectors to bring new knowledge to bear on the world’s great challenges. University research is one of the mainsprings of growth in an economy that is increasingly defined William Barton Rogers, the Institute’s founding pres- by technology. A study released in February 2009 ident, believed that education should be both broad by the Kauffman Foundation estimates that MIT and useful, enabling students to participate in “the graduates had founded 25,800 active companies. -
An Interview with Ewine Van Dishoeck
Issue 52 j October 2018 . Dear Colleagues, Welcome to the 5th anniversary edition of AstroPAH! What better way to cele- brate this festive occasion with you than with a show of lasers as featured on our cover. This year’s Nobel Prize in physics went to Arthur Ashkin, Gerard´ Mourou and Donna Strickland for their ground-breaking work in creating tools made of light. As the cover reveals, this has been of utmost importance to multiple fields amongst which astronomy and chemistry. Noteworthy is that Donna Strickland is the 3rd woman ever to win a Nobel Prize in physics (and the 1st in over 50 years). We would further like to celebrate our anniversary with a tribute to our Kavli-price winner Ewine van Dishoeck, who was awarded this ”Nobel-price for astronomy” for her ”combined contributions to observational, theoretical, and laboratory astrochemistry, elucidating the life cycle of interstellar clouds and the formation of stars and planets” Enjoy our interview with her in the In Focus. Of course our newsletter itself is also ’In Focus’ with some nice numbers from your feedback, showing our impact in the community. Thanks to all of you who responded to our survey! We will take your feedback into account to improve our newsletter and continue to keep you updated on the rich field of PAH-related research. We also thank everyone who has sent their paper abstracts to us, in this issue and all previous ones. Once again, our abstract section is full of interesting papers on the- oretical, experimental, and observational studies of astronomical PAHs and so much more. -
Opening Ceremony
Opening ceremony Sir John Ball, President of the International Mathematical Union Your Majesty, Señor Ruiz Gallardón, Señora Cabrera, Señora Aguirre, Professor Manuel de León, Distinguished guests, Ladies and gentlemen, ¡Bienvenidos al ICM dos mil seis! Welcome to ICM 2006, the 25th International Congress of Mathematicians, and the first ICM to be held in Spain. We offer our heartfelt thanks to the Spanish nation, so rich in history and culture, for its invitation to Madrid. We greatly appreciate that His Majesty King Juan Carlos is honouring mathematics by His presence here today. While celebrating this feast of mathematics, with the many talking-points that it will provide, it is worth reflecting on the ways in which our community functions. Mathematics is a profession of high standards and integrity. We freely discuss our work with others without fear of it being stolen, and research is communicated openly prior to formal publication. Editorial procedures are fair and proper, and work gains its reputation through merit and not by how it is promoted. These are the norms operated by the vast majority of mathematicians. The exceptions are rare, and they are noticed. Mathematics has a strong record of service, freely given. We see this in the time and care spent in the refereeing of papers and other forms of peer review. We see it in the running of mathematical societies and journals, in the provision of free mathematical software and teaching resources, and in the various projects world-wide to improve electronic access to the mathematical literature, old and new. We see it in the nurturing of students beyond the call of duty. -
Professor Peter Goldreich Member of the Board of Adjudicators Chairman of the Selection Committee for the Prize in Astronomy
The Shaw Prize The Shaw Prize is an international award to honour individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence. The award is dedicated to furthering societal progress, enhancing quality of life, and enriching humanity’s spiritual civilization. Preference is to be given to individuals whose significant work was recently achieved and who are currently active in their respective fields. Founder's Biographical Note The Shaw Prize was established under the auspices of Mr Run Run Shaw. Mr Shaw, born in China in 1907, was a native of Ningbo County, Zhejiang Province. He joined his brother’s film company in China in the 1920s. During the 1950s he founded the film company Shaw Brothers (HK) Limited in Hong Kong. He was one of the founding members of Television Broadcasts Limited launched in Hong Kong in 1967. Mr Shaw also founded two charities, The Shaw Foundation Hong Kong and The Sir Run Run Shaw Charitable Trust, both dedicated to the promotion of education, scientific and technological research, medical and welfare services, and culture and the arts. ~ 1 ~ Message from the Chief Executive I warmly congratulate the six Shaw Laureates of 2014. Established in 2002 under the auspices of Mr Run Run Shaw, the Shaw Prize is a highly prestigious recognition of the role that scientists play in shaping the development of a modern world. Since the first award in 2004, 54 leading international scientists have been honoured for their ground-breaking discoveries which have expanded the frontiers of human knowledge and made significant contributions to humankind.