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Professor Peter Goldreich Member of the Board of Adjudicators Chairman of the Selection Committee for the Prize in Astronomy
The Shaw Prize The Shaw Prize is an international award to honour individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence. The award is dedicated to furthering societal progress, enhancing quality of life, and enriching humanity’s spiritual civilization. Preference is to be given to individuals whose significant work was recently achieved and who are currently active in their respective fields. Founder's Biographical Note The Shaw Prize was established under the auspices of Mr Run Run Shaw. Mr Shaw, born in China in 1907, was a native of Ningbo County, Zhejiang Province. He joined his brother’s film company in China in the 1920s. During the 1950s he founded the film company Shaw Brothers (HK) Limited in Hong Kong. He was one of the founding members of Television Broadcasts Limited launched in Hong Kong in 1967. Mr Shaw also founded two charities, The Shaw Foundation Hong Kong and The Sir Run Run Shaw Charitable Trust, both dedicated to the promotion of education, scientific and technological research, medical and welfare services, and culture and the arts. ~ 1 ~ Message from the Chief Executive I warmly congratulate the six Shaw Laureates of 2014. Established in 2002 under the auspices of Mr Run Run Shaw, the Shaw Prize is a highly prestigious recognition of the role that scientists play in shaping the development of a modern world. Since the first award in 2004, 54 leading international scientists have been honoured for their ground-breaking discoveries which have expanded the frontiers of human knowledge and made significant contributions to humankind. -
Cambridge's 92 Nobel Prize Winners Part 4 - 1996 to 2015: from Stem Cell Breakthrough to IVF
Cambridge's 92 Nobel Prize winners part 4 - 1996 to 2015: from stem cell breakthrough to IVF By Cambridge News | Posted: February 01, 2016 Some of Cambridge's most recent Nobel winners Over the last four weeks the News has been rounding up all of Cambridge's 92 Nobel Laureates, which this week comes right up to the present day. From the early giants of physics like JJ Thomson and Ernest Rutherford to the modern-day biochemists unlocking the secrets of our genome, we've covered the length and breadth of scientific discovery, as well as hugely influential figures in economics, literature and politics. What has stood out is the importance of collaboration; while outstanding individuals have always shone, Cambridge has consistently achieved where experts have come together to bounce their ideas off each other. Key figures like Max Perutz, Alan Hodgkin and Fred Sanger have not only won their own Nobels, but are regularly cited by future winners as their inspiration, as their students went on to push at the boundaries they established. In the final part of our feature we cover the last 20 years, when Cambridge has won an average of a Nobel Prize a year, and shows no sign of slowing down, with ground-breaking research still taking place in our midst today. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1.1996 James Mirrlees, Trinity College: Prize in Economics, for studying behaviour in the absence of complete information As a schoolboy in Galloway, Scotland, Mirrlees was in line for a Cambridge scholarship, but was forced to change his plans when on the weekend of his interview he was rushed to hospital with peritonitis. -
Martin Karplus &LISTING RELEASE IMMEDIATE for 7:30 PM PM 7:30 SEP 24 52 East 11 Cultural New Forum Austrian York SEP 25 1953 Photographs MARTIN KARPLUS Exhib
FOR IMMEDIATE RELEASE & LISTING Exhibition: MARTIN KARPLUS Photographs 1953 – 2009 SEP 25 – NOV 28, 2014 Austrian Cultural Forum New York 11 East 52nd Street, New York SEP 24 | EXHIBITION OPENING 7:30 PM – 9PM (no RSVP req'd) Self Portrait of Martin Karplus, Marineland of the pacific, California, USA 1956 Martin Karplus is a chemist, Professor emeritus at Harvard University, and Nobel laureate who has spent the past treet treet york| new | ny 10022 | phone:(212) 319 5300 | (212) fax: 644 8660 [email protected] | | www.acfny.org fifty years consumed by a passion for documenting humanity in thousands of photographs. Sourced from Europe, s Asia, and the Americas, these photographs candidly capture societies at pivotal moments in their cultural and nd economic development in rich Kodachrome color. From September 25 through November 28, the Austrian Cultural Forum New York will present these works in his first ever New York retrospective, Martin Karplus | Photographs 1953- 2009. In 1953, nearing the completion of his PhD at Cal Tech, the Austrian-born, American Karplus received his uncle’s Leica camera as a gift from his parents and headed to Oxford University on a fellowship. In the ensuing years he austriancultural forum | east 11 52 would spend months on end exploring the globe, documenting what he describes in his artist statement as a “vision of a world, much of which no longer exists”. Images from the Netherlands, Denmark, Greece, Italy, France, Yugoslavia, and Germany present the closure of a bygone lifestyle as societies modernized and rebuilt in the wake of World War II and the dawning of the Cold War. -
From the Cover Contents
July 26, 2011 u vol. 108 u no. 30 u 12187–12560 Cover image: Pictured is a Tasmanian devil (Sarcophilus harrisii), a carnivorous marsupial whose numbers are dwindling due to an infectious facial cancer called Devil Facial Tumor Disease. Webb Miller et al. sequenced the genome of devils from northwest and south- east Tasmania, spanning the range of this threatened species on the Australian island. The authors report that the sequences reveal a worrisome dearth of genetic diversity among devils, suggesting the need for genetically characterized stocks to help breed hardier devils that might be better equipped to fight diseases. See the article by Miller et al. on pages 12348–12353. Image courtesy of Stephan C. Schuster. From the Cover 12348 Decoding the Tasmanian devil genome 12283 Illuminating chromosomal architecture 12295 Symmetry of cultured cells 12319 Caloric restriction and infertility 12366 Genetic diversity among ants Contents COMMENTARIES 12189 Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group THIS WEEK IN PNAS nucleosomal-2 (HMGN2) association Catherine A. Musselman and Tatiana G. Kutateladze See companion article on page 12283 12187 In This Issue 12191 Examining the establishment of cellular axes using intrinsic chirality LETTERS (ONLINE ONLY) Jason C. McSheene and Rebecca D. Burdine See companion article on page 12295 E341 Difference between restoring and predicting 3D 12193 Secrets of palm oil biosynthesis revealed structures of the loops in G-protein–coupled Toni Voelker receptors by molecular modeling See companion article on page 12527 Gregory V. Nikiforovich, Christina M. Taylor, Garland R. Marshall, and Thomas J. Baranski E342 Reply to Nikiforovich et al.: Restoration of the loop regions of G-protein–coupled receptors Dahlia A. -
REAL-TIME IMAGING of NITRIC OXIDE (NO) SIGNALS DERIVED from DIFFERENTIALLY TARGETED ENDOTHELIAL NITRIC OXIDE SYNTHASES (Enos) USING GENETICALLY ENCODED BIOSENSORS
T.C. BIRUNI UNIVERSITY INSTITUTE OF GRADUATE EDUCATION DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS MOLECULAR AND MEDICAL GENETICS GRADUATE PROGRAM REAL-TIME IMAGING OF NITRIC OXIDE (NO) SIGNALS DERIVED FROM DIFFERENTIALLY TARGETED ENDOTHELIAL NITRIC OXIDE SYNTHASES (eNOS) USING GENETICALLY ENCODED BIOSENSORS Mete Emir ÖZGÜRSES ADVISOR Asst. Prof. Dr. Emrah EROĞLU July, 2020 T.C. BIRUNI UNIVERSITY INSTITUTE OF GRADUATE EDUCATION DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS MOLECULAR AND MEDICAL GENETICS GRADUATE PROGRAM REAL-TIME IMAGING OF NITRIC OXIDE (NO) SIGNALS DERIVED FROM DIFFERENTIALLY TARGETED ENDOTHELIAL NITRIC OXIDE SYNTHASES (eNOS) USING GENETICALLY ENCODED BIOSENSORS Mete Emir ÖZGÜRSES ADVISOR Asst. Prof. Dr. Emrah EROĞLU July, 2020 III DECLARATION I declare that I have designed and performed all experiments in the current study entitled “Real-time imaging of nitric oxide (NO) signals derived from differentially targeted endothelial nitric oxide synthases (eNOS) using genetically encoded biosensors” according to good scientific practices. I obtained all the information contained in this thesis under academic and ethical rules. All the information I have used from secondary literature has been respectively referenced. I also declare that have not violated any patents and copyrights during the preparation and writing of this thesis. Mete Emir Ozgurses IV To all human being, V ACKNOWLEDGEMENT I would like to express my deepest gratitude to everyone who has supported me through this thesis. Firstly, I would like to thank Asst. Prof. Emrah Eroğlu for allowing me to work in his lab. He has guided me throughout the project both by challenging me to be more competent in science and by sharing his instructive ideas. -
Mcgovern Institute for Brain Research
McGovern Institute for Brain Research The McGovern Institute for Brain Research at MIT is a research and teaching institute committed to advancing human understanding and communications. The goal of the McGovern Institute is to investigate and ultimately understand the biological basis of higher brain function in humans. The Institute is conducting interdisciplinary research that combines and extends the results of recent breakthroughs in three major, interrelated areas: systems and computational neuroscience, imaging and cognitive neuroscience, and genetic and cellular neuroscience. Activities We initiated a faculty search during spring 2007. Although we reviewed over 100 applications, we ultimately decided not to make an offer and will instead run the search again in 2007–2008. We held our second annual imaging symposium at the McGovern Institute on May 15, 2007. The co-organizers of this year’s event were Christopher Moore, Alan Jasanoff, and Charles Jennings. The theme, “Plumbing the Mind: Brain Activation and the Regulation of Cerebral Blood Flow,” brought together people working on the physiological mechanisms of neurovascular coupling with others interested in the development of brain imaging technology, especially (but not exclusively) fMRI. Held in the brain and cognitive sciences complex, it was an oversubscribed event that was incredibly well received. The Institute’s Annual Scolnick Prize lecture and dinner was held May 21, 2007. The winner, Dr. David Julius, gave a late afternoon talk, followed by a well-attended dinner at the McGovern Institute. The Scolnick Prize recognizes an outstanding discovery or significant advance in the field of neuroscience. The McGovern Institute held its 5th annual retreat June 3–5 at the Newport Marriott in Newport, Rhode Island. -
Wake Forest Magazine Offers a 70 Class Notes Series of Milestones Along with the Millstones in the Story of Women at the University
CAMPUS DURING COVID-19 | WFU WOMEN: A HISTORY OF THEIR OWN | KAREN BAYNES-DUNNING (’89): UNDAUNTED SPRING 2021 R E A D I N G t h e R I V E R THE MAGAZINE OF WAKE FOREST UNIVERSITY FEATURES 38 COPING IN THE PANDEMIC Photography by Ken Bennett Wake Forest’s director of photography captured the first month of the fall semester, when campus community members embraced “Show Humanitate.” 2 52 READING THE RIVER LESSONS FROM A TIME OF By Carol L. Hanner UPHEAVAL Yadkin Riverkeeper Brian Fannon (’89) By Kerry M. King (’85) combines biology, history and a love of water Six alumni reflect on student life in the for his exceptional life in the flow. 1960s and early ’70s and how 2020 echoes those times. 18 88 UNDAUNTED CONSTANT & TRUE By Maria Henson (’82) By Sophie Hollis (’19) Karen Baynes-Dunning (’89) infuses arduous A young grad learns about isolation and work for social justice and children’s progress reaching out in a pandemic. with lessons from wondrous family lore. 34 DEPARTMENTS A HISTORY OF THEIR OWN 66 Around the Quad Illustration by Lisa Perrin As women move into their second century of 69 Philanthropy voting rights, Wake Forest Magazine offers a 70 Class Notes series of milestones along with the millstones in the story of women at the University. WAKEFOREST FROM theh PRESIDENT MAGAZINE 2019 ROBERT SIBLEY this issue of wake forest magazine is the first of 2021, a year MAGAZINE OF THE YEAR that will mark the University’s continuing challenges with the COVID-19 pandemic and an upcoming personal milestone for me and my wife, Julie. -
Nfap Policy Brief » October 2019
NATIONAL FOUNDATION FOR AMERICAN POLICY NFAP POLICY BRIEF» OCTOBER 2019 IMMIGRANTS AND NOBEL PRIZES : 1901- 2019 EXECUTIVE SUMMARY Immigrants have been awarded 38%, or 36 of 95, of the Nobel Prizes won by Americans in Chemistry, Medicine and Physics since 2000.1 In 2019, the U.S. winner of the Nobel Prize in Physics (James Peebles) and one of the two American winners of the Nobel Prize in Chemistry (M. Stanley Whittingham) were immigrants to the United States. This showing by immigrants in 2019 is consistent with recent history and illustrates the contributions of immigrants to America. In 2018, Gérard Mourou, an immigrant from France, won the Nobel Prize in Physics. In 2017, the sole American winner of the Nobel Prize in Chemistry was an immigrant, Joachim Frank, a Columbia University professor born in Germany. Immigrant Rainer Weiss, who was born in Germany and came to the United States as a teenager, was awarded the 2017 Nobel Prize in Physics, sharing it with two other Americans, Kip S. Thorne and Barry C. Barish. In 2016, all 6 American winners of the Nobel Prize in economics and scientific fields were immigrants. Table 1 U.S. Nobel Prize Winners in Chemistry, Medicine and Physics: 2000-2019 Category Immigrant Native-Born Percentage of Immigrant Winners Physics 14 19 42% Chemistry 12 21 36% Medicine 10 19 35% TOTAL 36 59 38% Source: National Foundation for American Policy, Royal Swedish Academy of Sciences, George Mason University Institute for Immigration Research. Between 1901 and 2019, immigrants have been awarded 35%, or 105 of 302, of the Nobel Prizes won by Americans in Chemistry, Medicine and Physics. -
2014-2015 Annual Report
THE HELEN HAY WHITNEY FOUNDATION 2014-2015 Annual REport 20 Squadron Boulevard, Suite 630 New City, NY 10956 www.hhwf.org Tel: (845) 639-6799 Fax: (845) 639-6798 THE HELEN HAY WHITNEY FOUNDATION BOARD OF TRUSTEES Averil Payson Meyer, President Steven C. Harrison, Ph.D., Vice President Lisa A. Steiner, M.D., Vice President W. Perry Welch, Treasurer Thomas M. Jessell, Ph.D. Payne W. Middleton Thomas P. Sakmar, M.D. Stephen C. Sherrill SCIENTIFIC ADVISORY COMMITTEE Steven C. Harrison, Ph.D., Chairman David J. Anderson, Ph.D. Daniel Kahne, Ph.D. Philippa Marrack, Ph.D. Markus Meister, Ph.D. Barbara J. Meyer, Ph.D. Julie A. Theriot, Ph.D. Jonathan S. Weissman, Ph.D. S. Lawrence Zipursky, Ph.D. ADMINISTRATIVE DIRECTOR and SECRETARY Robert Weinberger Page 1 REPORT OF THE VICE PRESIDENT AND CHAIRMAN, SCIENTIFIC ADVISORY COMMITTEE I am pleased to report on two years of activity for the Scientific Advisory Committee. Our charge, to select an outstanding group of Fellows each year and to respond as needed to advisory issues that occasionally arise during the tenure of their fellowship, is always a stimulating one, and the talks from third-year Fellows at the Annual Meeting continue to give remarkably positive feedback. Our partnerships with HHMI, the Simons Foundation, and Merck have benefitted the program greatly. We have three Simons Fellows, eight HHMI Fellows and two Merck Fellows, in addition to the eleven we now support from endowment income. (Let me add, on behalf of the SAC, a note of thanks to Perry Welch, the Treasurer of the Foundation, who oversees that endowment with great dedication and insight.) A class of 24 means the competition is fierce, and we continue to identify an extraordinary group of young biomedical scientists. -
SCIENCE and SUSTAINABILITY Impacts of Scientific Knowledge and Technology on Human Society and Its Environment
EM AD IA C S A C I A E PONTIFICIAE ACADEMIAE SCIENTIARVM ACTA 24 I N C T I I F A I R T V N Edited by Werner Arber M O P Joachim von Braun Marcelo Sánchez Sorondo SCIENCE and SUSTAINABILITY Impacts of Scientific Knowledge and Technology on Human Society and Its Environment Plenary Session | 25-29 November 2016 Casina Pio IV | Vatican City LIBRERIA EDITRICE VATICANA VATICAN CITY 2020 Science and Sustainability. Impacts of Scientific Knowledge and Technology on Human Society and its Environment Pontificiae Academiae Scientiarvm Acta 24 The Proceedings of the Plenary Session on Science and Sustainability. Impacts of Scientific Knowledge and Technology on Human Society and its Environment 25-29 November 2016 Edited by Werner Arber Joachim von Braun Marcelo Sánchez Sorondo EX AEDIBVS ACADEMICIS IN CIVITATE VATICANA • MMXX The Pontifical Academy of Sciences Casina Pio IV, 00120 Vatican City Tel: +39 0669883195 • Fax: +39 0669885218 Email: [email protected] • Website: www.pas.va The opinions expressed with absolute freedom during the presentation of the papers of this meeting, although published by the Academy, represent only the points of view of the participants and not those of the Academy. ISBN 978-88-7761-113-0 © Copyright 2020 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form, or by any means, electronic, mechanical, recording, pho- tocopying or otherwise without the expressed written permission of the publisher. PONTIFICIA ACADEMIA SCIENTIARVM LIBRERIA EDITRICE VATICANA VATICAN CITY The climate is a common good, belonging to all and meant for all. -
Ucsf Magazine Winter 2020 Cover Illustration: Mike Mcquaid; This Spread: Perkins Eastman Whatinside Matters Ucsf
MAGAZINE Winter 2020 Special Issue The Future SPECIAL ISSUE // THE FUTURE FEATURES 14 The Climate Crisis Is a Health Crisis Medicine must reckon with the coming catastrophe. 22 The Essence of Who We Are When we gain precise control over our brains and our genes, what will it mean to be human? 28 Who Will Benefit from Precision Medicine? Mostly the white and the wealthy – unless health systems tackle disparities. 34 Better Parts Ageless muscles. Off-the-shelf organs. Bionic superlimbs. And more. 38 Emerging and Ebbing Threats We’re winning some battles against infectious diseases and losing others. 42 Postcards from the Future Four trailblazers share their visions for cancer, aging, mental health, and AI. 46 What Will Health and Medicine Look Like in 2050? UCSF experts weigh in on predictions. DEPARTMENTS 2 What Matters 3 Inside UCSF NEW HEIGHTS 12 Brain Trust In this artist’s rendering of UCSF’s reimagined 32 Big Picture Parnassus Heights campus, an open 48 UCSF: The Campaign promenade replaces the steep, west-side staircase to Koret Way. 49 Alumni Hub Learn more about the vision for the campus’s 54 Med Mystery future at ucsf.edu/cphp. UCSF MAGAZINE WINTER 2020 COVER ILLUSTRATION: MIKE MCQUAID; THIS SPREAD: PERKINS EASTMAN COVER ILLUSTRATION: WHATINSIDE MATTERS UCSF What will health look UCSF MAGAZINE WINTER 2020 • VOL. 8 NO. 2 like in the future? EDITOR-IN-CHIEF Cyril Manning EXECUTIVE EDITOR We are living in an age of biomedical dis- Anne Kavanagh SENIOR EDITOR ruptors: gene editing, artificial intelligence, Ariel Bleicher machine learning, robotics, and many others. -
Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel
International Journal of Molecular Sciences Article Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel Lucie Macikova 1,2 , Lenka Vyklicka 1, Ivan Barvik 3, Alexander I. Sobolevsky 4 and Viktorie Vlachova 1,* 1 Department of Cellular Neurophysiology, Institute of Physiology Czech Academy of Sciences, 142 20 Prague, Czech Republic 2 Department of Physiology, Faculty of Science, Charles University, 128 00 Prague, Czech Republic 3 Division of Biomolecular Physics, Institute of Physics, Faculty of Mathematics and Physics, Charles University, 121 16 Prague, Czech Republic 4 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA * Correspondence: [email protected]; Tel.: +420-296-442-711 Received: 23 July 2019; Accepted: 13 August 2019; Published: 16 August 2019 Abstract: The vanilloid transient receptor potential channel TRPV3 is a putative molecular thermosensor widely considered to be involved in cutaneous sensation, skin homeostasis, nociception, and pruritus. Repeated stimulation of TRPV3 by high temperatures above 50 ◦C progressively increases its responses and shifts the activation threshold to physiological temperatures. This use-dependence does not occur in the related heat-sensitive TRPV1 channel in which responses decrease, and the activation threshold is retained above 40 ◦C during activations. By combining structure-based mutagenesis, electrophysiology, and molecular modeling, we showed that chimeric replacement of the residues from the TRPV3 cytoplasmic inter-subunit interface (N251–E257) with the homologous residues of TRPV1 resulted in channels that, similarly to TRPV1, exhibited a lowered thermal threshold, were sensitized, and failed to close completely after intense stimulation. Crosslinking of this interface by the engineered disulfide bridge between substituted cysteines F259C and V385C (or, to a lesser extent, Y382C) locked the channel in an open state.