With Primary Site Investigator)

Daptomycin for AHO – Supplemental Digital Content

Supplemental Digital Content 2. Number of patients randomized by country and investigational site (with primary site investigator)

Daptomycin Comparator (N=75) (N=73) United States, n (%) 21 (28.0%) 20 (27.0%) UT Health Science Center Houston, Houston, TX 1 (1.3%) - Gloria P. Heresi, MD Children's Hospital of Orange County, Orange, CA 6 (8.0%) 5 (6.8%) Antonio Arrieta, MD Rady Children’s Hospital San Diego, San Diego, CA 6 (8.0%) 7 (9.5%) John Bradley, MD University of Nebraska Medical Center, Omaha, NE - 1 (1.4%) Kari Simonsen, MD UW-Madison, Madison, WI 2 (2.7%) - Ellen R. Wald, MD Toledo Children's Hospital, Toledo, OH 3 (4.0%) - Jeffrey Blumer, MD Children's Hospital of Michigan, Detroit, MI 1 (1.3%) 3 (4.1%) Jocelyn Ang, MD Levine Children's Hospital, Charlotte, NC - 3 (4.1%) Brian Scannell, MD Connecticut Children's Medical Center, Hartford, CT 1 (1.3%) - Nicolas Bennett, MD LSUHSC – Shreveport, Shreveport, LA - 1 (1.4%) John Vanchiere, MD, PhD Children’s Medical Center of Dallas, Dallas, TX 1 (1.3%) - Lawson Copley, MD Spain, n (%) 6 (8.0%) 9 (12.2%) Hospital Universitario de Getafe, Madrid - 1 (1.4%) Luis Manuel Prieto Tato, MD Hospital 12 de Octubre, Madrid - 1 (1.4%) Pablo Rojo, MD Hospital San Joan de Deu, Barcelona 2 (2.7%) 2 (2.7%) Juan Jose Garcia, MD Hospital Gregorio Marañon, Madrid - 1 (1.4%) Jesùs Saavedra-Lozano, MD Hospital Universitario La Fe de Valencia, Valencia 3 (4.0%) 4 (5.4%) Maria Carmen Otero, MD / Emilio Monteagudo Montesinos, MD Hospital Clínico Universitario de Santiago de Compostela, Santiago 1 (1.3%) - de Compostela Frederico Martinon Torres, MD Ukraine, n (%) 14 (18.7%) 17 (23.0%) Dnipropetrovsk Children Clinical Hospital, Dnipropetrovsk 10 (13.3%) 12 (16.2%) Valeriy Digtyar, Prof. City Children's Hospital, Poltava - 2 (2.7%) Igor Ksonz, M.D., PhD Medical and Diagnostic Center of Acinus, Kirovograd 4 (5.3%) 3 (4.1%) Volodymyr Bilyy, MD

Daptomycin for AHO – Supplemental Digital Content

Germany, n (%) 3 (4.0%) 2 (2.7%) University Medical Center Freiburg, Freiburg 1 (1.3%) - Marcus Hufnagel, MD Universitätsklinikum Carl Gustav Carus, Dresden 2 (2.7%) 1 (1.4%) Reinhard Berner, MD Asklepios-Klinik Sankt Augustin, Sankt Augustin - 1 (1.4%) Gerd Horneff, Prof. Greece, n (%) 3 (4.0%) 2 (2.7%) Hippokration Hospital, Thessaloniki 2 (2.7%) 1 (1.4%) Emmanuel Roilides, Prof. Aghia Sophia Children's Hospital, Athens - 1 (1.4%) Athanasios Michos, Prof. Heraklion University Hospital, Heraklion 1 (1.3%) - Emmanuel Galanakis, Prof. Bulgaria, n (%) 3 (4.0%) - University Multiprofile Hospital “Dr. Georgi Stranski”, Pleven 1 (1.3%) - Borislav Ninov, Assoc. Prof. University Multiprofile Hospital “N. I. Pirogov”, Sofia 2 (2.7%) - Stefan Stoilov, Dr. Russia, n (%) 4 (5.3%) 3 (4.1%) Smolensk Regional Clinical Hospital, Smolensk 1 (1.3%) 1 (1.4%) Antonina Zuzova, Dr. Territorial Children's Clinical Hospital, Stavropol 3 (4.0%) 2 (2.7%) Alexander Yagoda, Dr. South Africa, n (%) 6 (8.0%) 6 (8.1%) Chris Hani Baragwanath Hospital, Johannesburg 5 (6.7%) 5 (6.8%) Aysha Badat, Dr. Lakeview Hospital, Johannesburg 1 (1.3%) 1 (1.4%) Ismail Haroon Mitha, Dr. Argentina, n (%) 2 (2.7%) - Hospital Italiano Regional del Sur, Buenos Aires 2 (2.7%) - Eduardo Teplitz, MD Australia, n (%) - 1 (1.4%) The Geelong Hospital, Victoria - 1 (1.4%) Eugene Athan, MD Chile, n (%) 1 (1.3%) 2 (2.7%) Hospital Gustavo Fricke, Viña del Mar 1 (1.3%) 2 (2.7%) Karen Ducasse, MD Estonia, n (%) 1 (1.3%) - Tallinn Children's Hospital, Tallinn 1 (1.3%) - Matis Martson, Dr. France, n (%) 1 (1.3%) 1 (1.4%) CHU Estaing, Clermont Ferrand 1 (1.3%) 1 (1.4%) Federico Canavese, MD Georgia, n (%) - 1 (1.4%) M. Iashvili Children’s Central Hospital, Tbilisi - 1 (1.4%) Tinatin Antadze, Dr. Israel, n (%) 1 (1.3%) - Pediatrics Hille Yaffe MC, Hadera 1 (1.3%) - Adi Klein-Kremer, MD Italy, n (%) 3 (4.0%) 5 (6.8%) University of Milano, Milano 3 (4.0%) 5 (6.8%) Susanna Esposito, Prof. Latvia, n (%) 4 (5.3%) 4 (5.4%)

Daptomycin for AHO – Supplemental Digital Content

Children's Clinical University Hospital, Riga 4 (5.3%) 4 (5.4%) Arnis Engelis, Prof. Malaysia, n (%) 1 (1.3%) - Hospital Sultan Abdul Hali, SunGai Petani Kedah 1 (1.3%) - Vijaya Kumar AL L.Suppan, MD Panama, n (%) - 1 (1.4%) Hospital del Niño, Panama - 1 (1.4%) Dora Estripeaut, MD United Kingdom, n (%) 1 (1.3%) 1 (1.4%) Great North Children's Hospital, Newcastle 1 (1.3%) 1 (1.4%) Marieke Emonts, Dr.