November 2001 Volume 2, Number 1 Dermal Toxicology Specialty Section

successful program committee will be Executive Council helpful in directly building the

President reputation and membership of DTSS.

G. Frank Gerberick, Ph.D. I am also pleased to announce that DTSS Procter & Gamble will be sponsoring two student awards [email protected] for 2002. The Awards Committee is

President-Elect being chaired by Suzana Theophilus with assistance from our Past-President, Jim E. Riviere, DVM, Ph.D. Anna Shvedova. A description of the North Carolina State University awards and the information required for [email protected] President’s Message participating is listed on the DTSS Vice-President website.

Ian Kimber, Ph.D. s stated in our last DTSS newsletter, Finally, just a reminder that our DTSS Syngenta the executive council’s number one A Reception has been scheduled for [email protected] priority for this year is to build the Monday, March 18, 2002. Hope to see DTSS’s membership by at least 50%. Secretary-Treasurer Guilin Qiao and other members of his you in Nashville!

Jeffrey D. Laskin, Ph.D. membership committee have been very G. Frank Gerberick UMDNJ - Robert Wood Johnson active in recruiting new members to the [email protected] Medical School Dermal Toxicology Specialty Section. In [email protected] addition, they have been working closely

with SOT headquarters to get a solid Counselors read on our current DTSS membership. I Committee Updates pleased to announce that our DTSS Diane A. Heck, Ph.D. Rutgers University membership has risen from 64 to 81 paid [email protected] members since last year’s SOT meeting. Membership Committee The current membership list is posted on Submitted by Guilin Qiao B. Jean Meade, Ph.D our DTSS website. Thanks to Guilin and CDC/NIOSH other Membership Committee members embership in the DTSS is [email protected] for all their hard work. We’re hoping M growing! As of Oct. 2001, our that the news will be even better in the records indicated a total of 84 members Anna A. Shvedova, Ph.D., DSc. coming months following their (81 reported from SOT Headquarters CDC/NIOSH completion of their current recruiting and 3 which are in-process). This [email protected] effort. Please help them in any way you reflects a 30% increase in membership can. since June. In order to maintain a viable,

active specialty section, we must The Dermal Toxicology Specialty Section Another key priority for DTSS is to have continue to grow our membership. Two newsletter is published 3 times/year (March, a very active Program Committee. This July, November) in electronic format. If you new recruiting efforts were implemented Committee is being lead by our recently through email; one was to would like to share a book review, meeting President-Elect, Jim Riviere. Jim is report, web site, or any other item of general ensure current DTSS members’ interest to the specialty section, please send it to already working with his committee on a continued participation when they renew the editors by the beginning of the month prior few ideas for the 2003 SOT meeting. As their SOT membership and the second, to the listed publication dates. We also you already know, DTSS will be co- was to encourage “Potential Members” welcome any comments or suggestions sponsoring a symposium entitled, Alter to select the DTSS Section on their SOT pertaining to overall content or format. Gene Expression and Cutaneous invoices. The committee is also Toxicity at next years SOT meeting planning additional recruiting activities Michael K. Robinson, Editor Nashville, TN. The symposium has been The Procter & Gamble Co. for the 2002 meeting in March. As a Cincinnati, Ohio 45253 slotted for Tuesday, March 19, 2002. DTSS member, you can take an active Tel. 53-627-2192; Fax. 513-627-0400 Please support DTSS and attend this role in growing our specialty section. If [email protected] symposium, which looks to be a very each member would encourage just one interesting and informative session. If person to join the DTSS we could Lisa K. Ryan, Associate Editor any of you have ideas for symposium, UMDNJ double our numbers. Mentors, workshops or continuing education remember that student and postdoctoral Newark, NJ 07103 courses for the 2003 annual meeting, Tel. 973-972-2624 SOT members are permitted to join one [email protected] please send your ideas to Jim Riviere. Specialty Section for free. There is no doubt that having a

An updated membership list, based on the Lisa K. Ryan, Co-Chair 3. Include the following information Oct. 2001 roster, will be posted on the [email protected] with your abstract submission: DTSS page on the SOT website. To Name provide the most accurate information University possible to our Derm-Tox community, Methods Committee Department the membership committee is asking that Program (BS, MS, PhD, other) Submitted by Robert L. Bronaugh you CAREFULLY CHECK the list and Year of study in the program

TAKE ACTIONS accordingly if: Email, phone, fax o promote the development and Advisor Name understanding of dermal toxicology 1.) You are a paid member of DTSS T Advisor email, phone, fax methods, the Methods Committee has and your name is not on the posted Indicate if you are planning to developed a preliminary program for an list. Check your personal records attend the SOT meeting SOT symposium. The outline for the and contact SOT to verify that they suggested symposium entitled received your payment. Also please 1. Deadline; February 15, 2002 "Disruption of Protein Phosphorylation notify the DTSS membership 2. Winners will be notified within the in Dermal Toxicity" has been forwarded committee. (If you are a member week before the SOT meeting and you are on the list, we thank to the Program Committee for their 3. Awards will be presented at the you!) review. SOT DTSS Business Meeting 2.) Your listed contact information is Robert L. Bronaugh, Chair (contact Anna Shvedova for inaccurate. Contact the DTSS [email protected] meeting information) membership committee and provide Elena A. Serbinova, Co-Chair them with the corrected [email protected] Eugenia (Suzana) Theophilus information. [email protected]

The membership committee would like to Awards Committee Anna Shvedova thank our president, Frank Gerberick, for Submitted by Anna Shvedova [email protected] his guidance, and the membership committee, for their hard work and Dermal Toxicology Specialty Section determination. And especially want to Student Awards 2002 Program Committee thank you, the DTSS members, for your Submitted by Jim E. Riviere continued support. he SOT Dermal Toxicology T Specialty Section (DTSS) is pleased Solicitation of Ideas for Continuing Guilin Qiao, Chair to announce that DTSS and Avon Education and/or Scientific [email protected] Products, Inc. will sponsor a student Presentations for the 2003 SOT Brian C. Jones, Co-Chair award for in vitro skin research during Meeting: [email protected] the 2002 SOT meeting. In addition, DTSS and Procter & Gamble will t is that time of year again where our Communications Committee sponsor a student award for skin related I section needs to seriously research. The award will recognize consider program ideas for the 2003 Submitted by Michael K. Robinson outstanding student candidates for their SOT meeting. Sponsoring and

contribution to advancing the co-sponsoring continuing education and he goal of the Communications understanding of skin toxicology and scientific platform sessions and Committee of the DTSS is to T pharmacology. Eligible and interested workshops are a major function of SOT coordinate the collection and students are encouraged to apply. Work specialty sections. Additionally, dissemination of information relevant to will be judged based on abstracts skin has been listed as a target area for the needs of dermal toxicologists within submitted prior to the SOT meeting. such programs. Formal submissions of the specialty section, as well as assisting Winner(s) will be announced at the programs are due in May, 2002 right the Council in outreach to the general annual meeting of the Dermal after the Nashville SOT meeting. It thus toxicology community. We do so Toxicology Specialty Section and will behooves us to seriously start thinking of through the use of a specialty section receive checks and diplomas. The programs which DTSS would like to newsletter and an SOT- linked web site. deadline for submission of abstracts is propose for the 2003 meeting. In that

February 25, 2002. line, Drs. Bob Bronaugh and Alan The newsletter is published 3 times each Brimfield have proposed a symposium year (currently March, July, and Eligible and interested students are on "Disruption of Protein November) and contains reports from the encouraged to apply! Phosphorylation in Dermal Toxicity" president, committee updates, job and are working on the specifics of such postings, member news, member honors For more information, contact: a meeting. Also, should other and awards, and member publications. Dr. Eugenia (Suzana) Theophilus, DTSS specialty sections have concepts that The newsletter is sent to all members by Awards Committe Chair overlap with our section's focus email and is posted to the web site. The ([email protected]) on skin, co-sponsorship of proposals is web site includes postings of the DTSS or beneficial. by-laws, current DTSS membership, Dr. Anna Shvedova, DTSS Past- current DTSS council members, special President and Student Award Committee I urge you to contact me with any ideas announcements, the annual report, a member ([email protected]) you may have so that these can President's Corner, and the current and be properly presented at a meeting of the previous DTSS newsletters. Guidelines for the DTSS Student DTSS Program Committee in

Award submission 2001: Nashville next year. Note: We are aware that the currently 1. Prepare an extra copy of the posted web site information is outdated abstract or platform presentation Jim E. Riviere, DVM, PhD; Chair, (with the exception of the newsletters). submitted to the SOT during DTTS Program Committee, Updated information will be sent to SOT abstract submissions Phone: (919) 513-6305 for posting as soon as possible. 2. Send copy via email to Suzana [email protected]

Theophilus at Michael K. Robinson, Chair [email protected] [email protected] 2 Dermal Toxicology Specialty Section

Meetings. Students need to register for

Member Comments/Views the Placement service. There is no Position Announcement charge for students. Postdoctoral Fellow e encourage your enthusiastic W involvement and suggestions! Opportunity at Take a moment and send us your Procter & Gamble comments. – eds.

Special Announcement Procter & Gamble Co. has an opportunity for a postdoctoral Meeting Announcement DTSS member, Richard P. Moody, notes that the Automated In Vitro fellow at P&G’s Miami Valley From: Valerian Kagan Dermal Absorption (AIDA) Laboratories in Cincinnati, protocol IP-53 developed at Health Ohio. ext summer, jointly with colleagues Canada, has recently been updated N from Russia we are organizing an Posdoctoral Fellow – Skin Allergy (ad and is available at http://ecvam- international meeting in St. Petersburg on code NAUSRD001258): The individual Reactive Oxygen and Nitrogen sis.jrc.it/ a new Web database of the will work on the development of Species. We plan to have a special European Centre for the Validation alternative, in vitro methods for session on oxidative stress in skin. of Alternative Methods (ECVAM). predicting skin allergy. The scope of the We'll be glad to have DTSS members The updated method has several research program involves developing an participate in the meeting (in fact revisions from the earlier protocol understanding of the chemical, Dr. J. Laskin and A. Shvedova are that was previously available from metabolic, and molecular actively involved in organization of (toxicogenomics) aspects of skin allergy. the meeting). You can find the details on the Fund for the Replacement of Animals in Medical Experiments the website listed below. Job Responsibilities: Carry out in-life (FRAME), including brief mention and in vitro experiments involving International Symposium of the dermal QSAR research area. molecular and genomic approaches. After surfing to the ECVAM RNA isolation and characterization, St. Petersburg, Russia July 9-13, 2002 Scientific Information Service (SIS) PCR, RT-PCR, methods to model skin database, SIS access is available metabolism and other techniques will be Reactive Oxygen and Nitrogen Species: after registering and obtaining a used to answer basic questions about Diagnostic, Preventive, and Therapeutic mechanisms of skin allergy caused by Values password. To locate the protocol simply click on the "Test Protocols" toxicant exposure. http://info.fbm.msu.ru/RN/ button, click again on the Job Requirements: A Ph.D. or INVITTOX pop-up window and equivalent in life sciences, with a Special Seminar enter AIDA as a search keyword in background in molecular and/or the "Method Name" box. Rick immunology. Announcement mentions he is particularly pleased how well a photo of the aluminum Please apply online at special seminar announcement for AIDA cell chamber displays at the http://www.pg.com/jobs/apply_now and A graduate students and postdoctoral Website following some minor PC refer to the appropriate ad code. Only fellows: applicants currently living in North electronic 'touchup'. America can be considered for this SEMINAR: "HOW TO MARKET position. YOURSELF AS A TOXICOLOGIST"

The Placement-Career Development Seminar "How to Market Yourself as a Toxicologist" will emphasize the basics DTSS Meeting at SOT of marketing one's abilities in order to Member Publications become a successful and satisfied professional in the "real world". The Attending the 2002 SOT ach newsletter will feature a listing seminar will be held on Monday, March meeting in Nashville? E of specialty section member 18, 2002, from 4:30-6:00 PM. Remember to put the our publications (journal articles, book Placement-Career Development Service chapters, books) that have appeared in is also co-sponsoring "How To Negotiate specialty section meetings on print since the last edition While the A Top Salary" with the Women in your event calendar. editors will do their best to survey the Toxicology Specialty Section, to be held indexing services relative to the current immediately afterward from 6:00 PM- DTSS Reception: membership roster, it is likely that some 7:30 PM, March 18, 2002. For further mistakes and omissions will occur. This details log on to: Monday March 18, 2002 is particularly true for books and book http://www.toxicology.org/publicoutreac 6:00 – 7:30 P.M. chapters. If we have inadvertently h/placement/placement.html Lincoln D Ballroom omitted a recent publication or listed something incorrectly, please advise us Placement-Career Development Services by email and we will see that this is provide members with a year-round DTSS Officers Meeting: corrected in the following newsletter. On-Line Service linking job candidates Monday March 18, 2002 Also, we welcome your help in this with employers and positions in 11:30 A.M. – 1:00 P.M. endeavor. Please send us your citations toxicology and related biological sciences Location to follow for any recently published articles and and the Service at the Annual books. That will aid us in our literature searching. Thank you - eds.

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Recent Publications (DTSS authors in Warbrick EV, Dearman RJ, Kimber I. Bissell DM, Gores GJ, Laskin DL, bold): Prediction of drug allergenicity: Hoofnagle JH. Drug-induced liver possible use of the local lymph node injury: mechanisms and test systems. Allen DG, Riviere JE, Monteiro- assay. Current Opinion in Drug Hepatology. Apr;33(4):1009-1913, Riviere NA. Analysis of interleukin-8 Discovery and Development 4:60-65, 2001. release from normal human epidermal 2001. keratinocytes exposed to aliphatic Morio LA, Chiu H, Sprowles KA, Zhou hydrocarbons: delivery of hydrocarbons Wright ZM, Basketter DA, Blaikie L, P, Heck DE, Gordon MK, Laskin DL. to cell cultures via complexation with Cooper KJ, Warbrick EV, Dearman RJ, Distinct roles of tumor necrosis factor- alpha-cyclodextrin. Toxicol In Vitro. Kimber I. Vehicle effects on skin alpha and nitric oxide in acute liver 15:663-669, 2001. sensitizing potency of four chemicals: injury induced by carbon tetrachloride in assessment using the local lymph node mice. Toxicol Appl Pharmacol. 172:44- Riviere JE, Qiao G, Baynes RE, Brooks assay. International Journal of Cosmetic 51, 2001. JD. Mumtaz M. Mixture component Science 23:75-83, 2001. effects on the in vitro dermal absorption Cox RL, Mariano T, Heck DE, Laskin of pentachlorophenol. Kimber I, Dearman RJ. Can animal JD, Stegeman JJ. Nitric oxide synthase Arch Toxicol. 75:329-334, 2001. models predict food allergenicity? sequences in the marine fish Stenotomus Nutrition Bulletin 26: 127-131, 2001. chrysops and the sea urchin Arbacia Baynes RE, Brooks JD, Budsaba K, punctulata, and phylogenetic analysis of Smith CE, Riviere JE. Mixture effects of Dearman RJ, Caddick H, Stone S, nitric oxide synthase calmodulin- JP-8 additives on the dermal disposition Basketter DA, Kimber I. binding domains. Comp Biochem of jet fuel components. Toxicol Appl Characterization of antibody responses Physiol B Biochem Mol Biol. 130:479- Pharmacol. 175:269-281, 2001. induced in rodents by exposure to food 491, 2001. proteins: influence of route of exposure. Tang J, Cao Y, Rose RL, Brimfield AA, Toxicology 167:217-231, 2001. Porterfield DM, Laskin JD, Jung SK, Dai D, Goldstein JA, Hodgson E. Malchow RP, Billack B, Smith PJ, Heck Metabolism of chlorpyrifos by human Kimber I, Pichowski JS, Betts CJ, DE. Proteins and lipids define the cytochrome P450 isoforms and human, Cumberbatch M, Basketter DA, diffusional field of nitric oxide. mouse, and rat liver microsomes. Dearman RJ. Alternative approaches to Am J Physiol Lung Cell Mol Physiol. Drug Metab Dispos. 29:1201-1204, 2001. the identification and characterization of 281:L904-L912, 2001. chemical allergens. Toxicology in Vitro Gad, SC. Regulatory Toxicology, 2nd 15:307-312, 2001. Kagan VE, Laskin JD. Ed., Taylor & Francis, Philadelphia, PA., Direct and indirect antioxidant effects of 2001. Basketter DA, Kimber I. Predictive nitric oxide: radically unsettled issues. testing in contact allergy: facts and Antioxid Redox Signal. 3:173-175, Gad, SC. Safety Evaluation of Medical future. Allergy 56:937-943, 2001. 2001. Devices and Biomaterials, 2nd Ed., Marcel Dekker, NY., 2001. Craighead MW, Middlehurst KML, Sugawara T, Gallucci RM, Simeonova LeFeuvre R, Kimber I, Rothwell NJ. PP, Luster MI. Regulation and role of Basketter DA, Wright ZM, Warbrick EV, Oxidised adenosine 5’-triphosphate, a interleukin 6 in wounded human Dearman RJ, Kimber I, Ryan CA, P2X7 antagonist, is toxic to rat cerebellar epithelial keratinocytes. Gerberick GF, White IR. Human granule neurones in vitro. Neuroscience Cytokine. 15:328-336, 2001. potency predictions for aldehydes using Letters 311:77-80, 2001. the local lymph node assay. Gallucci RM, Sugawara T, Yucesoy B, Contact Dermatitis. 45:89-94, 2001. Kimber I, Basketter DA, Roggeband R. Berryann K, Simeonova PP, Matheson Chemical respiratory allergy: JM, Luster MI. Interleukin-6 treatment Gerberick GF, Robinson MK, Ryan classification and labelling. Toxicology augments cutaneous wound healing in CA, Dearman RJ, Kimber I, Basketter 167:159-162, 2001. immunosuppressed mice. J Interferon DA, Wright Z, Marks JG. Contact Cytokine Res. 21:603-609, 2001. allergenic potency: correlation of human Laskin DL, Weinberger B, Laskin JD. and local lymph node assay data. Functional heterogeneity in liver and Luster MI, Simeonova PP, Gallucci Am J Contact Dermat. 12:156-161. lung macrophages. RM, Bruccoleri A, Blazka ME, Yucesoy J Leukoc Biol. 70:163-170, 2001. B. Role of inflammation in chemical- Lemus R, Lukinskeine L, Bier ME, induced hepatotoxicity. Toxicol Lett. Wisnewski AV, Redlich CA, Karol MH. Laskin JD, Heck DE, Gardner CR, 120:317-321, 2001. Development of immunoassays for Laskin DL. Prooxidant and antioxidant biomonitoring of hexamethylene functions of nitric oxide in liver toxicity. Yucesoy B, Vallyathan V, Landsittel diisocyanate exposure. Environ Health Antioxid Redox Signal. 3:261-271, DP, Sharp DS, Weston A, Burleson GR, Perspect. 109:1103-1108, 2001. 2001. Simeonova P, McKinstry M, Luster MI. Association of tumor necrosis factor- Landrigan PJ, Mattison DR, Boardman B, Billack B, Heck DE, Porterfield DM, alpha and interleukin-1 gene Bruckner JV, Jackson RJ, Karol MH, Malchow RP, Smith PJ, Gardner CR, polymorphisms with silicosis. Toxicol Krewski D, Weil WB, Charnley GM. Laskin DL, Laskin JD. Minimal Appl Pharmacol. 172:75-82, 2001. Correspondence. amidine structure for inhibition of nitric Environ Health Perspect. 109:A412-413. oxide biosynthesis. Biochem Pharmacol. Simeonova PP, Wang S, Kashon ML, 2001. 61:1581-1586, 2001. Kommineni C, Crecelius E, Luster MI. Quantitative relationship between Matheson JM, Lange RW, Lemus R, Weinberger B, Weiss K, Heck DE, arsenic exposure and AP-1 activity in Karol MH, Luster MI. Importance of Laskin DL, Laskin JD. Pharmacologic mouse urinary bladder epithelium. inflammatory and immune components in therapy of persistent pulmonary Toxicol Sci. 60:279-284, 2001. a mouse model of airway reactivity to hypertension of the newborn. toluene diisocyanate (TDI). Clin Exp Pharmacol Ther. 89:67-79, 2001. Luster MI. Ozone-induced mucous cell Allergy. 31:1067-1076, 2001. metaplasia. Toxicol Sci. 60:193, 2001.

4 Dermal Toxicology Specialty Section

Handbook of Cosmetic Science and Utility of Radiolabel Blood Area under Technology, A.O. Berel, M. Paye, and Hikima T, Ohno Y, Maibach HI. the Curve and Excretion Data in Dermal H.I. Maibach, eds., Marcel Dekker, New Metabolism of prednisolone 21-acetate Absorption Calculations and Tissue York, pp 95-106, 2001. in hairless mouse skin. Skin Pharmacol Exposure Assessment. Toxicol Appl Appl Skin Physiol. 14:203-209, 2001. Pharmacol. 177:26-37, 2001. Maibach HI, Mathias CT. Allergic contact dermatitis from cycloaliphatic Hikima T, Maibach HI. Distribution of Martin-Jimenez T, Riviere JE. Mixed epoxide in jet aviation hydraulic fluid. hydrolytic activity catalyzes the effects modeling of the disposition of Contact Dermatitis. 45:56, 2001. biotransformation of prednisolone 21- gentamicin across domestic animal acetate in human skin. Skin Pharmacol species. J Vet Pharmacol Ther. 24:321- Shah MG, Maibach HI. Estrogen and Appl Skin Physiol. 14:196-202, 2001. 332, 2001. skin. An overview. Am J Clin Dermatol. 2:143-150, 2001. McDougal JN, Jurgens-Whitehead JL. Riviere JE, Papich MG. Potential and Short-Term dermal absorption and problems of developing transdermal Koehler AM, Maibach HI. Electronic penetration of chemicals from aqueous patches for veterinary applications. monitoring in medication adherence solutions: theory and experiment. Adv Drug Deliv Rev. 50:175-203, 2001. measurement. Implications for Risk Anal. 21:719-26, 2001. dermatology. Am J Clin Dermatol.2:7-12, Perkins MA, Osterhues MA, Farage 2001. Rogers JV, Gunasekar PG, Garrett CM, MA, Robinson MK. A Noninvasive McDougal JN. Dermal Exposure to m- method to assess skin irritation and Lee EE, Maibach HI.Treatment of Xylene Leads to Increasing Oxidative compromised skin conditions using urticaria. An evidence-based evaluation Species and Low Molecular Weight simple tape adsorption of molecular of antihistamines. Am J Clin Dermatol. DNA Levels in Rat Skin. J Biochem Mol markers of inflammation. Skin Res. 2:27-32, 2001. Toxicol. 15:228-230, 2001. Technol. 7:227-237, 2001.

Boukhman MP, Maibach HI. Thresholds Kabbur MB, Rogers JV, Gunasekar PG, Robinson MK, Osborne R, Perkins MA. in contact sensitization: Immunologic Garrett CM, Geiss KT, Brinkley WW, In vitro tests for skin irritation. In: mechanisms and experimental evidence McDougal JN. Effect of JP-8 jet fuel on Handbook of Cosmetic Science and in humans-an overview. Food Chem molecular and histological parameters Technology, A.O. Berel, M. Paye, and Toxicol. 39:1125-1134, 2001. related to acute skin irritation. Toxicol H.I. Maibach, eds., Marcel Dekker, New Appl Pharmacol. 175:83-88, 2001. York, pp 95-106, 2001. Bashir SJ, Maibach HI. Alefacept (Biogen). Curr Opin Investig Drugs. Inman AO, Olivry T, Dunston SM, Robinson MK, Perkins MA. Evaluation 2:631-634, 2001. Monteiro-Riviere NA, Gatto H. of a quantitative clinical method for Electron microscopic observations of assessment of sensory skin irritation. Levin CY, Maibach HI. Do cool water stratum corneum intercellular lipids in Contact Dermatitis. 45:205-213, 2001. or physiologic saline compresses enhance normal and atopic dogs. Vet Pathol. resolution of experimentally-induced 38:720-723, 2001. Robinson MK. Intra-individual irritant contact dermatitis? Contact variations in acute and cumulative skin Dermatitis. 45:146-150, 2001. Monteiro-Riviere NA, Inman AO, Mak irritation responses. Contact Dermatitis. V, Wertz P, Riviere JE. Effect of 45:75-83, 2001. Mallon J, Chu MT, Maibach HI. selective lipid extraction from different Occupational allergic contact dermatitis body regions on epidermal barrier Roy TA, Singh R. Effect of soil loading from methyl chloroform (1,1,1- function. Pharm Res. 18:992-998, 2001. and soil sequestration on dermal trichloroethane)? Contact Dermatitis. bioavailability of polynuclear aromatic 45:107, 2001. Rame A, Inyang F, Hood DB, hydrocarbons. Bull Environ Contam Archibong AE, Knuckles ME, Nyanda Toxicol. 67:324-331, 2001. Jerschow E, Hostynek JJ, Maibach HI. AM. Metabolism, bioavailability, and Allergic contact dermatitis elicitation toxicokinetics of benzo(alpha)pyrene in Regal JF, Mohrman ME, Sailstad DM. thresholds of potent allergens in humans. F-344 rats following oral administration. Trimellitic anhydride-induced Food Chem Toxicol. 39:1095-1108, Exp Toxicol Pathol. 53:275-290, 2001. eosinophilia in a mouse model of 2001. occupational asthma. Toxicol Appl Sams RL 2nd, Couch LH, Miller BJ, Pharmacol. 175:234-242, 2001. Singh J, Gross M, Sage B, Davis HT, Okerberg CV, Warbritton A, Wamer Maibach HI. Regional variations in skin WG, Beer JZ, Howard PC. Basal cell Shvedova AA, Kisin E, Kisin J, barrier function and cutaneous irritation proliferation in female SKH-1 mice Castranova V, Kommineni C. Elevated due to iontophoresis in human subjects. treated with alpha- and beta-hydroxy oxidative stress in skin of B6C3F1 mice Food Chem Toxicol. 39:1079-1086, acids. Toxicol Appl Pharmacol. 175:76- affects dermal exposure to metal 2001. 82, 2001. working fluid. Toxicol Ind Health 16:267-276, 2001. Dannaker CJ, Maibach HI, Austin E. McKim JM Jr, Wilga PC, Breslin WJ, Allergic contact dermatitis to Plotzke KP, Gallavan RH, Meeks RG. Kagan VE, Kuzmenko AI, Tyurina YY, proparacaine with subsequent cross- Potential estrogenic and antiestrogenic Shvedova AA, Matsura T, Yalowich JC. sensitization to tetracaine from activity of the cyclic siloxane Pro-oxidant and Antioxidant ophthalmic preparations. Am J Contact octamethylcyclotetrasiloxane (D4) and Mechanisms of Etoposide in HL-60 Dermat. 12:177-179, 2001. the linear siloxane hexamethyldisiloxane Cells: Role of Myeloperoxidase. (HMDS) in immature rats using the Cancer Res. 61:7777-7784, 2001. Sherertz EF, Fransway AF, Belsito DV, uterotrophic assay. Toxicol Sci. 63:37- DeLeo VA, Fowler JF Jr, Maibach HI, 46, 2001. Shvedova AA, Tyurina YY, Tyurin VA, Marks JG Jr, Mathias CG, Pratt MD, Kikuchi Y, Kagan VE, Quinn PJ. Rietschel RL, Taylor JS. Patch testing Qiao GL, Riviere JE. Enhanced Quantitative analysis of phospholipid discordance alert: false-negative findings Systemic Tissue Distribution after peroxidation and antioxidant protection with rubber additives and fragrances. J Dermal versus Intravenous 3,3',4,4'- in live human epidermal keratinocytes. Am Acad Dermatol. 45:313-314, 2001. Tetrachlorobiphenyl Exposure: Limited Biosci Rep. 21:33-43, 2001. 5 Dermal Toxicology Specialty Section