Interactions with Nnrtis Charts Revised June 2019

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Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 1 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

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EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV + RPV + RPV + RPV + DOR DOR 3TC/TDF 3TC/TDF Anaesthetics & Muscle Relaxants Antibacterials Alcuronium         Amikacin         Bupivacaine         Amoxicillin         Cisatracurium         Ampicillin         Desflurane         Azithromycin         Dexmedetomidine         Bedaquiline         Enflurane         Capreomycin         Ephedrine         Cefalexin         Halothane         Cefazolin         Isoflurane         Cefixime         Ketamine         Cefotaxime         Nitrous oxide         Ceftazidime         Propofol         Ceftriaxone         Rocuronium         Chloramphenicol         Sevoflurane         Ciprofloxacin         Sufentanil         Clarithromycin         Suxamethonium (succinylcholine)         Clavulanic acid         Tetracaine         Clindamycin         Thiopental         Clofazimine         Tizanidine         Cloxacillin         Vecuronium         Cycloserine         Analgesics Dapsone         Alfentanil         Delamanid         Aspirin         Doxycycline         Buprenorphine         Ertapenem         Celecoxib         Erythromycin        

Codeine         distribution. for Not only. use r personal Ethambutol         Dextropropoxyphene         Ethionamide         Diamorphine (diacetylmorphine)         Flucloxacillin         Diclofenac         Gentamicin         Dihydrocodeine         Imipenem/Cilastatin         Fentanyl         Isoniazid         Hydrocodone         Kanamycin        

Hydromorphone         Fo istribution. Levofloxacin         Ibuprofen         Linezolid         Mefenamic acid         Meropenem         Methadone         Metronidazole         Morphine         Moxifloxacin         Naproxen         Nitrofurantoin         Nimesulide         Ofloxacin         Oxycodone         Para-aminosalicylic acid         Paracetamol (Acetaminophen)         Penicillins         Pethidine (Meperidine)         Pyrazinamide         Piroxicam         Rifabutin         Tapentadol         Rifampicin         Tramadol         Rifapentine         Anthelmintics Rifaximin         Albendazole         Spectinomycin         Diethylcarbamazine         Streptomycin         Ivermectin         Sulfadiazine         Levamisole (Ergamisol)         Telithromycin         Mebendazole         Tetracyclines         Niclosamide         Trimethoprim/Sulfamethoxazole         Oxamniquine         Vancomycin         Praziquantel         Anti-coagulant, Anti-platelet and Fibrinolytic Pyrantel         Acenocoumarol         Suramin sodium         Apixaban         Triclabendazole        Argatroban         Antiarrhythmics Aspirin (anti-platelet)         Amiodarone         Betrixaban         Bepridil         Clopidogrel         Disopyramide         Dabigatran         Dofetilide         Dalteparin         Flecainide         Dipyridamole         Lidocaine (Lignocaine)         Edoxaban         Mexiletine         Eltrombopag         Enoxaparin         Propafenone         for d Not only. use For personal for distribution. Not only. use For personal Quinidine         Fondaparinux         Heparin         Phenprocoumon         Prasugrel         Rivaroxaban         Streptokinase         Ticagrelor         Warfarin        

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and unboosted regimens, the charts reflect the more cautious option. DOR Doravirine (Pifeltro®) RPV Rilpivirine (Edurant®)  These drugs should not be coadministered DOR + Doravirine + RPV + Rilpivirine + © Liverpool Drug Interaction Group, University of Liverpool 3TC+ Lamivudine+Tenofovir-DF DTG Dolutegravir Potential interaction – may require close monitoring, Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF ® ®  TDF (Delstrigo ) (Juluca ) alteration of drug dosage or timing of administration EFV Efavirenz RPV + Rilpivirine + We aim to ensure that information is accurate and consistent with current knowledge and practice. ®, ® Potential interaction likely to be of weak intensity. (Sustiva Stocrin ) F/TAF Emtricitabine + Additional action/monitoring or dosage adjustment is However, the University of Liverpool and its servants or agents shall not be responsible or in any Tenofovir alafenamide way liable for the continued currency of information in this publication whether arising from ® unlikely to be required ETV Etravirine (Intelence ) (Odefsey®) negligence or otherwise howsoever or for any consequences arising therefrom. The University of ® Liverpool expressly exclude liability for errors, omissions or inaccuracies to the fullest extent NVP Nevirapine (Viramune )  No clinically significant interaction expected permitted by law.

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Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 2 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

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EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV RPV + RPV RPV + DOR DOR 3TC/TDF 3TC/TDF Anticonvulsants Antifungals Carbamazepine         Amphotericin B         Clonazepam         Anidulafungin         Eslicarbazepine         Caspofungin         Ethosuximide         Fluconazole         Gabapentin         Flucytosine         Lacosamide         Griseofulvin         Lamotrigine         Itraconazole         Levetiracetam         Ketoconazole         Oxcarbazepine         Miconazole         Phenobarbital (Phenobarbitone)         Nystatin         Phenytoin         Posaconazole         Pregabalin         Terbinafine         Primidone         Voriconazole         Tiagabine         Antihistamines Topiramate         Astemizole         Valproate (Divalproex)         Cetirizine         Vigabatrin         Chlorphenamine         Zonisamide         Diphenhydramine         Antidepressants Fexofenadine         Agomelatine         Levocetirizine         Amitriptyline         Loratadine         Bupropion         Promethazine         Citalopram         Terfenadine         Clomipramine         Antimigraine Agents Desipramine         Almotriptan         Doxepin         distribution. for Not only. use r personal Dihydroergotamine         Duloxetine         Ergotamine         Escitalopram         Rizatriptan         Fluoxetine         Sumatriptan         Fluvoxamine         Antiprotozoals      Imipramine    Amodiaquine           Lithium       Artemisinin         Maprotiline         Fo istribution. Atovaquone              Mianserine    Benznidazole         Milnacipran         Chloroquine         Mirtazapine         Diloxanide               Nefazodone   Eflornithine         Nortriptyline         Halofantrine         Paroxetine         Lumefantrine                 Phenelzine Mefloquine         Reboxetine         Meglumine antimoniate         Sertraline         Melarsoprol                 Tranylcypromine Miltefosine         Trazodone         Nifurtimox         Trimipramine         Paromomycin              Venlafaxine    Pentamidine         Vortioxetine         Piperaquine         Anti-diabetics Primaquine         Acarbose         Proguanil         Canagliflozin         Pyrimethamine         Dapagliflozin         Quinine         Dulaglutide         Sodium stibogluconate         Empagliflozin         Sulfadoxine         Exanatide         Antipsychotics/Neuroleptics Glibenclamide (Glyburide)         Amisulpride         Gliclazide         Aripiprazole         Glimepiride         Asenapine         Glipizide         Chlorpromazine         Insulin         Clozapine         Linagliptin         Fluphenazine         Liraglutide         Haloperidol         Metformin         Iloperidone         Nateglinide         Levomepromazine         Pioglitazone         Olanzapine         Repaglinide         Paliperidone        

Rosiglitazone         for d Not only. use For personal for distribution. Not only. use For personal Perazine         Saxagliptin         Periciazine         Sitagliptin         Perphenazine         Tolbutamide         Pimozide         Vildagliptin         Pipotiazine         Quetiapine         Risperidone         Sulpiride         Thioridazine         Tiapride         Ziprasidone         Zotepine         Zuclopenthixol        

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Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 3 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

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EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV RPV + RPV RPV + DOR DOR 3TC/TDF 3TC/TDF Antivirals Calcium Channel Blockers Aciclovir         Amlodipine         Adefovir         Diltiazem         Amantadine         Felodipine         Boceprevir         Nicardipine         Cidofovir         Nifedipine         Daclatasvir         Nisoldipine         Elbasvir/Grazoprevir         Nitrendipine         Entecavir         Verapamil        

Famciclovir         Cancer Therapies Foscarnet         Anastrozole         Ganciclovir         Asparaginase         Glecaprevir/Pibrentasvir         Bevacizumab         Ledipasvir/sofosbuvir         Bexarotene         Ombitasvir/Paritaprevir/r         Bleomycin         Ombitasvir/Paritaprevir/r + Dasabuvir         Bortezomib         Oseltamivir         Capecitabine         Ribavirin         Carboplatin         Rimantadine         Cetuximab         Simeprevir         Chlorambucil         Sofosbuvir         Cisplatin         Sofosbuvir/Velpatasvir         Cyclophosphamide         Sofosbuvir/Velpatasvir/Voxilaprevir         Cytarabine         Telaprevir         Dacarbazine         Telbivudine         Dactinomycin         Tenofovir alafenamide (HBV)         Dasatinib        

Valaciclovir         distribution. for Not only. use r personal Daunorubicin         Zanamivir         Docetaxel         Anxiolytics/Hypnotics/ Sedatives Doxorubicin         Alprazolam         Droloxifene         Bromazepam         Epirubicin         Buspirone         Erlotinib         Chlordiazepoxide         Estramustine        

Clobazam         Fo istribution. Etoposide         Clorazepate         Everolimus         Diazepam         Exemestane         Estazolam         Fludarabine         Flunitrazepam         Fluorouracil         Flurazepam         Formestane         Hydroxyzine         Gefitinib         Lorazepam         Gemcitabine         Lormetazepam         Ifosfamide         Midazolam (oral)         Imatinib         Midazolam (parenteral)         Irinotecan         Oxazepam         Lapatanib         Temazepam         Letrozole         Triazolam         Mercaptopurine         Zaleplon         Mesna         Zolpidem         Methotrexate         Zopiclone         Mitoxantrone         Beta Blockers Nilotinib         Atenolol         Oxaliplatin         Bisoprolol         Paclitaxel         Carvedilol         Pazopanib         Metoprolol         Procarbazine         Nebivolol         Rituximab         Oxprenolol         Sorafenib         Pindolol         Sunitinib         Propranolol         Tamoxifen         Timolol         Temsirolimus         Topotecan         Bronchodilators Aclidinium bromide         Toremifene         Aminophylline         Vinblastine         Formoterol         Vincristine         Glycopyrronium bromide         Vorinostat         Indacaterol         Ipratropium bromide         for d Not only. use For personal for distribution. Not only. use For personal Montelukast         Olodaterol         Roflumilast         Salbutamol         Salmeterol         Theophylline         Tiotropium bromide         Umeclidinium bromide         Vilanterol        

www.hiv-druginteractions.org

Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 4 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

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EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV + RPV + RPV + RPV + DOR DOR 3TC/TDF 3TC/TDF Contraceptives/HRT Herbals/Supplements/Vitamins (continued) Desogestrel (COC)         Hops (Humulus lupulus)         Desogestrel (POP)         Inula racemosa         Drospirenone (COC)         Iodine         Drospirenone (HRT)         Iron supplements         Dydrogesterone (HRT)         Liquorice (Glycyrrhiza glabra)        Estradiol         Magnesium supplements         Ethinylestradiol         Malabar nut tree         Etonogestrel (implant)         Menthol        Etonogestrel (vaginal ring)         Milk thistle (silymarin)         Gestodene (COC)         Multivitamins         Levonorgestrel (COC)         Nicotinamide         Levonorgestrel (emergency contraception)         Phytomenadione (vitamin K)         Levonorgestrel (HRT)         Pyridoxine (vitamin B6)         Levonorgestrel (implant)         Quercetin         Levonorgestrel (IUD)         Retinol (vitamin A)         Levonorgestrel (POP)         Riboflavin (vitamin B2)         Medroxyprogesterone (depot injection)         Saw palmetto (Serenoa repens)         Medroxyprogesterone (oral)         Seville orange juice        Norelgestromin (patch)         St John's Wort         Norethisterone [Norethindrone] (COC)         Thiamine (vitamin B1)         Norethisterone [Norethindrone] (HRT)         Turmeric (Curcuma longa)         Norethisterone [Norethindrone] (IM depot)         Valerian         Norethisterone [Norethindrone] (POP)         Vitamin E         Norgestimate (COC)         Hypertension / Heart Failure Agents Norgestrel (COC)         Aliskiren        

Norgestrel (HRT)         distribution. for Not only. use r personal Ambrisentan         Ulipristal         Amiloride         Erectile Dysfunctional Agents Bendroflumethiazide         Avanafil         Bosentan         Sildenafil (Erectile Dysfunction)         Candesartan         Tadalafil (Erectile Dysfunction)         Captopril         Vardenafil         Chlortalidone         Gastrointestinal Agents Fo istribution. Cilazapril         Alosetron         Clonidine         Antacids         Digoxin         Bisacodyl         Dopamine         Cimetidine         Doxazosin         Cisapride         Enalapril         Esomeprazole         Eplerenone         Famotidine         Epoprostenol         Lactulose         Eprosartan         Lansoprazole         Fosinopril         Loperamide         Furosemide         Mesalazine         Hydralazine         Omeprazole         Hydrochlorothiazide         Pantoprazole         Iloprost         Prucalopride         Indapamide         Rabeprazole         Irbesartan         Ranitidine         Isosorbide dinitrate         Senna         Ivabradine         Gastrointestinal Agents (anti-emetics) Labetalol         Aprepitant         Lacidipine         Dolasetron         Lercanidipine         Domperidone         Lisinopril         Dronabinol         Losartan         Granisetron         Macitentan         Metoclopramide         Methyldopa         Ondansetron         Metolazone         Prochlorperazine         Olmesartan         Herbals/Supplements/Vitamins Perindopril         Prazosin         African potato         Quinapril         Aloe vera         Ramipril         Ascorbic Acid (vitamin C)         Ranolazine         Calcium supplements         Riociguat         Cat’s claw (Uncaria tomentosa)        Sacubitril         Colecalciferol (vitamin D3)         for d Not only. use For personal for distribution. Not only. use For personal Selexipag         Cubeb pepper (Piper cubeba)        Sildenafil (PAH)         Cyanocobalamin         Sodium nitroprusside         Echinacea       Spironolactone         Eucalyptus globulus         Tadalafil (PAH)         Folic acid         Telmisartan         Garlic         Terazosin         Ginger (Zinigiber officinale)        Torasemide         Ginkgo biloba        Trandolapril         Goldenseal root (Hydrastis canadensis)         Treprostinil         Grapefruit juice        Valsartan         Xipamide        

www.hiv-druginteractions.org

Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 5 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

+ + + +

EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV RPV + RPV RPV + DOR DOR 3TC/TDF 3TC/TDF

Illicit/Recreational Other Alcohol         Acamprosate         Amphetamine         Acetazolamide         Cannabis         Acitretin         Cocaine         Adrenaline (Epinephrine)         Ecstasy (MDMA)         Alendronic Acid         GHB (Gamma-hydroxybutyrate_         Alfuzosin         Heroin         Allopurinol         LSD (Lysergic acid diethylamide)         Atropine        

Mephedrone         Baclofen         Methamphetamine         Betahistine         Phencyclidine (PCP)         Poppers(Amyl nitrate)         Biperiden                 Immune Modulators Caffeine citrate Calcium folinate         Hydroxyurea (Hydroxycarbamide)         Cannabidiol (CBD)         Interferon alpha         Interleukin 2 (Aldesleukin)         Carbimazole         Peginterferon alfa-2a         Clomifene         Peginterferon alfa-2b         Colchicine         Immunosuppressants Cyproterone acetate         Adalimumab         Denosumab         Anti-thymocyte globulin         Disulfiram         Azathioprine         Dutasteride         Basiliximab         Finasteride         Belatacept         Flibanserin         Ciclosporin         Glyceryl trinitrate (Nitroglycerin)         Mycophenolate         Goserelin        

Sirolimus         distribution. for Not only. use r personal Ibandronic acid         Tacrolimus         Isotretinoin         Lipid Lowering Agents Leuprorelin         Atorvastatin         Levothyroxine         Bezafibrate         Mannitol         Clofibrate         Methylphenidate         Evolocumab         Modafinil         Ezetimibe         istribution. Fo istribution. Naftidrofuryl         Fenofibrate         Naloxone         Fish oils         Naltrexone         Fluvastatin         Neostigmine         Gemfibrozil         Nicorandil         Lovastatin         Orlistat         Pitavastatin         Penicillamine         Pravastatin         Rosuvastatin         Pentoxifylline         Simvastatin         Pilocarpine         Overactive Bladder Agents Potassium         Probenecid         Darifenacin                 Fesoterodine         Propylthiouracil Mirabegron         Protamine sulphate         Oxybutynin         Pyridostigmine         Solifenacin         Strontium ranelate         Tolterodine         Sulfasalazine         Trospium         Tamsulosin         Oxytocics Thalidomide         Ergometrine (Ergonovine)         Tranexamic acid         Mifepristone         Triptorelin         Misoprostol         Varenicline         Oxytocin         Zoledronic acid        

Parkinsonism Agents Apomorphine         Benserazide         Carbidopa         Levodopa         Pramipexole         Rasagiline         Ropinirole         Steroids Beclometasone         Betamethasone         Budesonide         Clobetasol         for d Not only. use For personal for distribution. Not only. use For personal Dexamethasone         Fludrocortisone         Fluocinolone         Fluticasone         Hydrocortisone (oral)         Hydrocortisone (topical)         Megestrol acetate         Methylprednisolone         Mometasone         Nandrolone         Oxandrolone         Prednisolone         Prednisone         Stanazolol         Testosterone         Triamcinolone        