www.hiv-druginteractions.org Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 1 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. + + EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV + RPV + RPV + RPV + DOR DOR 3TC/TDF 3TC/TDF Anaesthetics & Muscle Relaxants Antibacterials Alcuronium Amikacin Bupivacaine Amoxicillin Cisatracurium Ampicillin Desflurane Azithromycin Dexmedetomidine Bedaquiline Enflurane Capreomycin Ephedrine Cefalexin Halothane Cefazolin Isoflurane Cefixime Ketamine Cefotaxime Nitrous oxide Ceftazidime Propofol Ceftriaxone Rocuronium Chloramphenicol Sevoflurane Ciprofloxacin Sufentanil Clarithromycin Suxamethonium (succinylcholine) Clavulanic acid Tetracaine Clindamycin Thiopental Clofazimine Tizanidine Cloxacillin Vecuronium Cycloserine Analgesics Dapsone Alfentanil Delamanid Aspirin Doxycycline Buprenorphine Ertapenem Celecoxib Erythromycin Codeine distribution. for Not only. use r personal Ethambutol Dextropropoxyphene Ethionamide Diamorphine (diacetylmorphine) Flucloxacillin Diclofenac Gentamicin Dihydrocodeine Imipenem/Cilastatin Fentanyl Isoniazid Hydrocodone Kanamycin Hydromorphone Fo istribution. Levofloxacin Ibuprofen Linezolid Mefenamic acid Meropenem Methadone Metronidazole Morphine Moxifloxacin Naproxen Nitrofurantoin Nimesulide Ofloxacin Oxycodone Para-aminosalicylic acid Paracetamol (Acetaminophen) Penicillins Pethidine (Meperidine) Pyrazinamide Piroxicam Rifabutin Tapentadol Rifampicin Tramadol Rifapentine Anthelmintics Rifaximin Albendazole Spectinomycin Diethylcarbamazine Streptomycin Ivermectin Sulfadiazine Levamisole (Ergamisol) Telithromycin Mebendazole Tetracyclines Niclosamide Trimethoprim/Sulfamethoxazole Oxamniquine Vancomycin Praziquantel Anti-coagulant, Anti-platelet and Fibrinolytic Pyrantel Acenocoumarol Suramin sodium Apixaban Triclabendazole Argatroban Antiarrhythmics Aspirin (anti-platelet) Amiodarone Betrixaban Bepridil Clopidogrel Disopyramide Dabigatran Dofetilide Dalteparin Flecainide Dipyridamole Lidocaine (Lignocaine) Edoxaban Mexiletine Eltrombopag Enoxaparin Propafenone for d Not only. use For personal for distribution. only. Not use For personal Quinidine Fondaparinux Heparin Phenprocoumon Prasugrel Rivaroxaban Streptokinase Ticagrelor Warfarin Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and unboosted regimens, the charts reflect the more cautious option. DOR Doravirine (Pifeltro®) RPV Rilpivirine (Edurant®) These drugs should not be coadministered DOR + Doravirine + RPV + Rilpivirine + © Liverpool Drug Interaction Group, University of Liverpool 3TC+ Lamivudine+Tenofovir-DF DTG Dolutegravir Potential interaction – may require close monitoring, Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF ® ® TDF (Delstrigo ) (Juluca ) alteration of drug dosage or timing of administration EFV Efavirenz RPV + Rilpivirine + We aim to ensure that information is accurate and consistent with current knowledge and practice. ®, ® Potential interaction likely to be of weak intensity. (Sustiva Stocrin ) F/TAF Emtricitabine + However, the University of Liverpool and its servants or agents shall not be responsible or in any Additional action/monitoring or dosage adjustment is Tenofovir alafenamide way liable for the continued currency of information in this publication whether arising from ® unlikely to be required ETV Etravirine (Intelence ) (Odefsey®) negligence or otherwise howsoever or for any consequences arising therefrom. The University of ® Liverpool expressly exclude liability for errors, omissions or inaccuracies to the fullest extent NVP Nevirapine (Viramune ) No clinically significant interaction expected permitted by law. www.hiv-druginteractions.org Interactions with NNRTIs Charts revised June 2019. Full information available at www.hiv-druginteractions.org Page 2 of 5 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. + + + + EFV ETV EFV ETV NVP RPV NVP RPV DTG DTG DOR DOR F/TAF F/TAF RPV RPV + RPV RPV + DOR DOR 3TC/TDF 3TC/TDF Anticonvulsants Antifungals Carbamazepine Amphotericin B Clonazepam Anidulafungin Eslicarbazepine Caspofungin Ethosuximide Fluconazole Gabapentin Flucytosine Lacosamide Griseofulvin Lamotrigine Itraconazole Levetiracetam Ketoconazole Oxcarbazepine Miconazole Phenobarbital (Phenobarbitone) Nystatin Phenytoin Posaconazole Pregabalin Terbinafine Primidone Voriconazole Tiagabine Antihistamines Topiramate Astemizole Valproate (Divalproex) Cetirizine Vigabatrin Chlorphenamine Zonisamide Diphenhydramine Antidepressants Fexofenadine Agomelatine Levocetirizine Amitriptyline Loratadine Bupropion Promethazine Citalopram Terfenadine Clomipramine Antimigraine Agents Desipramine Almotriptan Doxepin distribution. for Not only. use r personal Dihydroergotamine Duloxetine Ergotamine Escitalopram Rizatriptan Fluoxetine Sumatriptan Fluvoxamine Antiprotozoals Imipramine Amodiaquine Lithium Artemisinin Maprotiline Fo istribution. Atovaquone Mianserine Benznidazole Milnacipran Chloroquine Mirtazapine Diloxanide Nefazodone Eflornithine Nortriptyline Halofantrine Paroxetine Lumefantrine Phenelzine Mefloquine Reboxetine Meglumine antimoniate Sertraline Melarsoprol Tranylcypromine Miltefosine Trazodone Nifurtimox Trimipramine Paromomycin Venlafaxine Pentamidine Vortioxetine Piperaquine Anti-diabetics Primaquine Acarbose Proguanil Canagliflozin Pyrimethamine Dapagliflozin Quinine Dulaglutide Sodium stibogluconate Empagliflozin Sulfadoxine Exanatide Antipsychotics/Neuroleptics Glibenclamide (Glyburide) Amisulpride Gliclazide Aripiprazole Glimepiride Asenapine Glipizide Chlorpromazine Insulin Clozapine Linagliptin Fluphenazine Liraglutide Haloperidol Metformin Iloperidone Nateglinide Levomepromazine Pioglitazone Olanzapine Repaglinide Paliperidone Rosiglitazone for d Not only. use For personal for distribution. only. Not use For personal Perazine Saxagliptin Periciazine Sitagliptin Perphenazine Tolbutamide Pimozide Vildagliptin Pipotiazine Quetiapine Risperidone Sulpiride Thioridazine Tiapride Ziprasidone Zotepine Zuclopenthixol Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and unboosted regimens, the charts reflect the more cautious option. DOR Doravirine (Pifeltro®) RPV Rilpivirine (Edurant®) These drugs should not be coadministered DOR + Doravirine + RPV + Rilpivirine + © Liverpool Drug Interaction Group, University of Liverpool 3TC+ Lamivudine+Tenofovir-DF DTG Dolutegravir Potential interaction – may require close monitoring, Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF ® ® TDF (Delstrigo ) (Juluca ) alteration of drug dosage or timing of administration EFV Efavirenz RPV + Rilpivirine + We aim to ensure that information is accurate and consistent with current knowledge and practice. ®, ® Potential interaction likely to be of weak intensity. (Sustiva Stocrin ) F/TAF Emtricitabine + However, the University of Liverpool and its servants or agents shall not be responsible or in any Additional action/monitoring or dosage adjustment is Tenofovir alafenamide way liable for the continued currency of information in this