Safe Drug Use for the Recovering Addict Or Alcoholic
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Insomnia and Anxiety in Older People Sleeping Pills Are Usually Not the Best Solution
® Insomnia and anxiety in older people Sleeping pills are usually not the best solution lmost one-third of older people in the people who take one of United States take sleeping pills. These these medicines sleep medicines are also sometimes called only a little longer and A“sedative-hypnotics” or “tranquilizers.” They better than those who affect the brain and spinal cord. don’t take a medicine. Doctors prescribe some of these medicines Sleeping pills can for sleep problems. Some of these medicines have serious side effects. also can be used to treat other conditions, such All sedative-hypnotic medicines have special as anxiety or alcohol withdrawal. Sometimes, risks for older adults. Seniors are likely to be doctors also prescribe certain anti-depressants more sensitive to the medicines’ effects than for sleep, even though that’s not what they’re younger adults. And these medicines may designed to treat. stay in older people’s bodies longer. These Most older adults should first try to treat their medicines can cause confusion and memory insomnia without medicines. According to the problems that: American Geriatrics Society, there are safer and • Increase the risk of falls and hip fractures. better ways to improve sleep or reduce anxiety. These are common causes of hospital stays Here’s why: and death in older people. Sleeping pills may not help much. • Increase the risk of car accidents. Many ads say that sleeping pills help people get a full, restful night’s sleep. But studies show that this is not exactly true in real life. On average, The new “Z” medicines also have risks. -
CSAS Narcotic Treatment Service for Opiate Addiction Initial Certification
DEPARTMENT OF HEALTH SERVICES STATE OF WISCONSIN Division of Quality Assurance Page 1 of 16 F-00538 (11/11) COMMUNITY SUBSTANCE ABUSE SERVICE (CSAS) NARCOTIC TREATMENT SERVICE FOR OPIATE ADDICTION INITIAL CERTIFICATION APPLICATION Chapter DHS 75.15 Initial Certification • Initial certification must meet all requirements, including staffing requirements (hired and in place) before services begin. • This document paraphrases the rule language for application purposes. • Applicants for a new narcotic treatment service for opiate addiction must demonstrate preparedness to comply with all Chapter DHS 75.15 standards. Applicants will have completed all required policies, including Chapter DHS 94 (Patient Rights). Use the check boxes ( ) to affirm readiness to meet standards. • ATTENTION: The clinic must contact the regional Health Services Specialist to arrange a site visit following the submission of fee and this application. Chapter DHS 75.01(1) Authority and Purpose This application is promulgated under the authority of ss. 46.973(2)(c), 51.42(7)(b), and 51.45(8) and (9), Wis. Stats., to establish standards for community substance abuse prevention and treatment services under ss. 51.42 and 51.45, Wis. Stats. Sections 51.42(1) and 51.45(1) and (7) provide that a full continuum of substance abuse services be available to Wisconsin citizens from county departments of community programs, either directly or through written agreements or contracts that document the availability of services. This application provides that service recommendations for initial placement, continued stay, level of care transfer, and discharge of a patient be made through the use of Wisconsin uniform placement criteria (WI- UPC), American Society of Addiction Medicine (ASAM) placement criteria, or similar placement criteria that may be approved by the department. -
Early Morning Insomnia, Daytime Anxiety, and Organic Mental Disorder Associated with Triazolam
Early Morning Insomnia, Daytime Anxiety, and Organic Mental Disorder Associated with Triazolam Tjiauw-Ling Tan, MD, Edward 0. Bixler, PhD, Anthony Kales, MD, Roger J. Cadieux, MD, and Amy L. Goodman, MD Hershey, Pennsylvania A psychiatric syndrome characterized by agita Sleep Disorders Clinic. He began taking triazolam tion, paranoid ideation, depersonalization, and de at bedtime in a 0.5-mg dose eight months before pression, as well as paresthesias and hyperacusis, his referral. Although the drug was effective ini has been attributed to administration of triazolam tially, tolerance developed, causing the patient to (Halcion).1 The occurrence of these reactions led gradually increase the dosage until eventually he to the removal of the drug from the market in the was taking a total of 1.5 mg nightly. Netherlands. Isolated behavioral side effects that The physical examination revealed no contribu include amnesia2-4 and hallucinations5 have also tory conditions. However, assessment of the pa been reported with administration of triazolam. tient’s mental status revealed that he was extreme Rebound insomnia6 and early morning insom ly guarded and suspicious and preoccupied with nia,7 both associated with increases in daytime his sleeplessness to the degree that this hypochon anxiety,7,8 are withdrawal syndromes known driacal concern had a delusional quality. He also to occur with rapidly eliminated benzodiazepine described two episodes indicating memory impair hypnotics such as triazolam. Rebound insomnia ment; both incidents occurred in the late afternoon consists of a marked increase in wakefulness and involved preparing to eat certain foods, which above baseline levels following drug withdrawal. -
Vademecum Agrovet Market Animal Health
Vademecum Agrovet Market Animal Health We are a Peruvian company focused on the development, production and commercialization of veterinary products, driving its technical and creative development to meet the needs of veterinarians and stock farmers with unique products of high quality. www.agrovetmarket.com Mission l Products of Unique Class Provide veterinary, nutritional and farmaceutical products of unique class; developed in a creative and innovative way, under high standards of quality that allow us to reach international markets and consolidate locally through the formal stablishment of strategical alliances. Antibiotics Line of large animals am Line of companion animals ac Line of poultry and swine av www.agrovetmarket.com Antibiotics ® Agrogenta 11 | Vetigen 11 Injectable Solution Broad-spectrum aminoglycoside Composition: Gentamicin (as sulphate) 110 mg, excipients q.s. ad 1 mL. Indications: Treatment and prevention of infections caused by microorganisms sensitive to gentamicin (of the urogenital, respiratory and gastrointestinal systems). Also useful in cases of mastitis, metritis, post-operatory and cutaneous infections, septicemias, among others.. Dosage and Administration: Cattle, horse, sheep, goat, swine, camelid: 1 mL/27.5 kg of b.w.; young animals, dogs and cats: 1 mL/14 kg; poultry: 0.1 mL/1.4 kg; every 24 hours for 3 to 5 consecutive days by subcutaneous or intramuscular route. Intrauterine or intra-mammary route: Cows: 2 mL diluted in 20 mL of physiological saline solution for 3 to 5 days. Mares: 20 mL diluted in 200 - 500 mL of physiological saline solution for 3 to 5 days (only intrauterine route). Commercial Presentation: Bottle x 100 mL and 250 mL. -
Preventing Alcohol and Other Drug Use in Student-Athletes
Preventing Alcohol and Other Drug Use in Student-Athletes Most Student-Athletes Alcohol Use Don’t Use/Misuse Most don’t misuse alcohol. See percentages of higher risk drinking within the last 12 months.* % of student-athletes reporting “never used” PERCENTAGES OF ALCOHOL USE EFFECTS ON ATHLETIC PERFORMANCE BASED ON AMOUNT 99.6% Heroin • Constricts aerobic metabolism and endurance 99.5% Methamphetamine Division I Division II Division III • Requires increased work to maintain 1.0% 1.6% 1.8% weight 99.1% Anabolic steroids Female • Inhibits absorption of nutrients, More than which then: 98.2% Ultracet, Ultram or Tramadol 4 drinks 38.9% 33.1% 41.2% - Reduces endurance 98.0% Amphetamines 10+ drinks - Decreases protein synthesis for muscle fiber repair 97.4% Human growth hormone (HGH) - Decreases immune response 97.3% Injectable Toradol - Increases risk of injury Male 10.7% 11.5% 15.8% • Alcohol use 24 hours before athletic 97.1% LSD More than activity significantly reduces aerobic 5 drinks 39.0% 38.6% 51.8% performance 96.1% Ecstacy/Molly 10+ drinks • Weekly alcohol consumption 94.5% Cocaine doubles the rate of injury 84.5% ADHD stimulants WITHIN THE 18.2% say they did not drink EFFECTS OF A HANGOVER 83.3% Narcotic pain medication within the last year LAST YEAR, • Increases heart rate HAVE YOU 75.3 % Marijuana • Decreases left ventricular performance EXPERIENCED A • Increases blood pressure 49.0% Tylenol or acetaminophen HANGOVER AS • Decreases endurance performance A CONSEQUENCE • Dehydration 44.6% NSAIDs OF DRINKING ALCOHOL? No: Yes: 19.8% Alcohol 29.8% 52% Marijuana Use Stimulant Use Narcotic Use Most don’t use marijuana. -
For Personal Use Only
SedatiWITH ANTIi ® Dowden Health Media CopyrightFor personal use only Initiate the antipsychotic at a reasonable, not overly high dose, then use a nonantipsychotic to help control insomnia, anxiety, and agitation For mass reproduction, content licensing and permissions contact Dowden Health Media. pSYCHIATRY i PSYCHOTICSon edation is a frequent side effect of antipsychot- ics, especially at relatively high doses. Antipsy- S chotics’ sedative effects can reduce agitation in acute psychosis and promote sleep in insomnia, but Manage, don’t long-term sedation may: • interfere with schizophrenia patients’ efforts to go accept adverse to work or school or engage in normal socialization • prevent improvement from psychosocial training, psychiatric rehabilitation, and other treatments. ‘calming’ eff ect This article discusses how to manage acute psycho- sis without oversedation and ways to address persistent sedation and chronic insomnia with less-sedating anti- Del D. Miller, PharmD, MD Professor of psychiatry psychotics or adjunctive medications. University of Iowa Carver College of Medicine Iowa City Neurobiology or psychopharmacology? Many patients experience only mild, transient som- nolence at the beginning of antipsychotic treatment, and most develop some tolerance to the sedating ef- fects with continued administration. Others may have persistent daytime sedation that interferes with nor- mal functioning. Sedation is especially common in elderly patients re- ceiving antipsychotics. Compared with younger patients, older patients receiving -
The Case of Ketamine Allergy
CASE REPORT The Case of Ketamine Allergy William Bylund, MD Department of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia Liam Delahanty, MD Maxwell Cooper, MD Section Editor: Rick A. McPheeters, DO Submission history: Submitted April 3, 2017; Revision received June 29, 2017; Accepted July 11, 2017 Electronically published October 3, 2017 Full text available through open access at http://escholarship.org/uc/uciem_cpcem DOI: 10.5811/cpcem.2017.7.34405 Ketamine is often used for pediatric procedural sedation due to low rates of complications, with allergic reactions being rare. Immediately following intramuscular (IM) ketamine administration, a three-year-old female rapidly developed facial edema and diffuse urticarial rash, with associated wheezing and oxygen desaturation. Symptoms resolved following treatment with epinephrine, dexamethasone and diphenhydramine. This case presents a clinical reaction to ketamine consistent with anaphylaxis due to histamine release, but it is uncertain whether this was immunoglobulin E mediated. This is the only case reported to date of allergic reaction to IM ketamine, without co- administration of other agents. [Clin Pract Cases Emerg Med.2017;1(4):323–325.] INTRODUCTION cardiac monitor, end tidal CO2 (ETCO2) and pulse oximetry Ketamine is a common medication, used in isolation as well (POx), in addition to being placed on two liters nasal cannula as with other agents, for pediatric sedation in the emergency (NC). No intravenous (IV) access was obtained prior to sedation. department (ED). It is often turned to because of its efficacy, ease Seventy milligrams (4.4mg/kg) of ketamine was administered IM of use, and favorable safety profile. Common side effects of into the right thigh. -
Diphenhydramine Dosage Sheet Concord Pediatrics, P.A
Diphenhydramine Dosage Sheet Concord Pediatrics, P.A. (603) 224-1929 BRAND NAMES: Benadryl INDICATIONS: Treatment of allergic reactions, nasal allergies, hives and itching. FREQUENCY: Repeat every 6 hours as needed. Don't give more than 4 times a day. DOSAGE: Determine by using the table below. Please speak with a medical provider before giving Diphenhydramine to a child under 1 year old. Child’s Dose in mg Children’s Liquid Chewable/Fastmelts Tabs/Caps/Gels Weight (lb) (12.5mg/ 5mL) 12.5mg tablets 25mg tablets *12-16 lbs 6.25 mg 2.5 mL *17-19 lbs 9.375 mg 3.75 mL *20-24 lbs 10 mg 4 mL 25-37 lbs 12.5 mg 5 mL 1 tab 38-49 lbs 18.75 mg 7.5 mL 1.5 tabs 50-69 lbs 25 mg 10 mL 2 tabs 1 tab 70-99 lbs 37.5 mg 15 mL 3 tabs 1.5 tabs >100 lbs 50 mg 20 mL 4 tabs 2 tabs Table Notes: *AGE LIMIT: For allergies, don't use under 1 year of age (Reason: it's a sedative). For colds, not recommended at any age (Reason: no proven benefits) and should be avoided if under 4 years old. Avoid multi-ingredient products in children under 6 years of age (Reason: FDA recommendations 10/2008). MEASURING the DOSAGE: Syringes and droppers are more accurate than teaspoons. If possible, use the syringe or dropper that comes with the medicine. If not, medicine syringes are available at pharmacies. Regular spoons are not reliable. ADULT DOSAGE: 50 mg Why use Diphenhydramine? Antihistamines can be used to treat your child’s runny nose, itchy eyes, and sneezing due to allergies. -
Hallucinogens
Hallucinogens What Are Hallucinogens? Hallucinogens are a diverse group of drugs that alter a person’s awareness of their surroundings as well as their thoughts and feelings. They are commonly split into two categories: classic hallucinogens (such as LSD) and dissociative drugs (such as PCP). Both types of hallucinogens can cause hallucinations, or sensations and images that seem real though they are not. Additionally, dissociative drugs can cause users to feel out of control or disconnected from their body and environment. Some hallucinogens are extracted from plants or mushrooms, and others are synthetic (human-made). Historically, people have used hallucinogens for religious or healing rituals. More recently, people report using these drugs for social or recreational purposes. Hallucinogens are a Types of Hallucinogens diverse group of drugs Classic Hallucinogens that alter perception, LSD (D-lysergic acid diethylamide) is one of the most powerful mind- thoughts, and feelings. altering chemicals. It is a clear or white odorless material made from lysergic acid, which is found in a fungus that grows on rye and other Hallucinogens are split grains. into two categories: Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) comes from certain classic hallucinogens and types of mushrooms found in tropical and subtropical regions of South dissociative drugs. America, Mexico, and the United States. Peyote (mescaline) is a small, spineless cactus with mescaline as its main People use hallucinogens ingredient. Peyote can also be synthetic. in a wide variety of ways DMT (N,N-dimethyltryptamine) is a powerful chemical found naturally in some Amazonian plants. People can also make DMT in a lab. -
Nitrous Oxide in Emergency Medicine Í O’ Sullivan, J Benger
214 ANALGESIA Emerg Med J: first published as 10.1136/emj.20.3.214 on 1 May 2003. Downloaded from Nitrous oxide in emergency medicine Í O’ Sullivan, J Benger ............................................................................................................................. Emerg Med J 2003;20:214–217 Safe and predictable analgesia is required for the identify these zones as there is considerable vari- potentially painful or uncomfortable procedures often ation between people. He also emphasised the importance of the patient’s pre-existing beliefs. If undertaken in an emergency department. The volunteers expect to fall asleep while inhaling characteristics of an ideal analgesic agent are safety, 30% N2O then a high proportion do so. An appro- predictability, non-invasive delivery, freedom from side priate physical and psychological environment increases the actions of N2O and may allow lower effects, simplicity of use, and a rapid onset and offset. doses to be more effective. Unlike many other Newer approaches have threatened the widespread use anaesthetic agents, N2O exhibits an acute toler- of nitrous oxide, but despite its long history this simple ance effect, whereby its potency is greater at induction than after a period of “accommoda- gas still has much to offer. tion”. .......................................................................... MECHANISM OF ACTION “I am sure the air in heaven must be this Some writers have suggested that N2O, like wonder-working gas of delight”. volatile anaesthetics, causes non-specific central nervous system depression. Others, such as 4 Robert Southey, Poet (1774 to 1843) Gillman, propose that N2O acts specifically by interacting with the endogenous opioid system. HISTORY N2O is known to act preferentially on areas of the Nitrous oxide (N2O) is the oldest known anaes- brain and spinal cord that are rich in morphine thetic agent. -
Analgesic Indications: Developing Drug and Biological Products
Guidance for Industry Analgesic Indications: Developing Drug and Biological Products DRAFT GUIDANCE This guidance document is being distributed for comment purposes only. Comments and suggestions regarding this draft document should be submitted within 60 days of publication in the Federal Register of the notice announcing the availability of the draft guidance. Submit electronic comments to http://www.regulations.gov. Submit written comments to the Division of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. All comments should be identified with the docket number listed in the notice of availability that publishes in the Federal Register. For questions regarding this draft document contact Sharon Hertz at 301-796-2280. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) February 2014 Clinical/Medical 5150dft.doc 01/15/14 Guidance for Industry Analgesic Indications: Developing Drug and Biological Products Additional copies available from: Office of Communications, Division of Drug Information Center for Drug Evaluation and Research Food and Drug Administration 10903 New Hampshire Ave., Bldg. 51, rm. 2201 Silver Spring, MD 20993-0002 Tel: 301-796-3400; Fax: 301-847-8714; E-mail: [email protected] http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) February -
The Misuse of Benzodiazepines Among High-Risk Opioid Users in Europe
EMBARGO — 7 JUNE 7. 6. 2018 UPDATED 11:30 Central European Time/CET (10:30 Western European Time/WET/Lisbon) Proof - 28 May 2018 not for circulation PERSPECTIVES ON DRUGS The misuse of benzodiazepines among high-risk opioid users in Europe Benzodiazepines are a widely prescribed I Introduction group of medicines with a range of clinical uses that include treating Benzodiazepines have a range of clinical uses and are among the most commonly prescribed medicines globally. anxiety, insomnia and managing alcohol They are useful in the short-term treatment of anxiety and withdrawal. This group of medicines is insomnia, and in managing alcohol withdrawal (Medicines often misused by high-risk opioid users, and Healthcare Products Regulatory Agency, 2015). Like all medicines, benzodiazepines can produce side effects. They and this is associated with considerable may also be misused, which we define as use without a morbidity and mortality. This paper prescription from a medical practitioner or, if prescribed, when describes the impact of benzodiazepines they are used outside accepted medical practice or guidelines. misuse on the health and treatment of While the misuse of benzodiazepines has been identified high-risk opioid users. as a concern for large groups in the general population, for example, among elderly people and women, this analysis focuses specifically on misuse among high-risk opioid users (1), a group of people among whom these medicines have been linked with severe treatment challenges and implicated in considerable numbers of drug-related deaths. It is important to stress that much benzodiazepine prescribing to high-risk drug users is done with legitimate therapeutic aims in mind.