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Interactions with Protease Inhibitors Charts Revised February 2018 www.hiv-druginteractions.org Interactions with Protease Inhibitors Charts revised February 2018. Full information available at www.hiv-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ATV Cobi DRV FPV IDV LPV RTV SQV TPV ATV Cobi DRV FPV IDV LPV RTV SQV TPV Anaesthetics & Muscle Relaxants Antibacterials (continued) Alcuronium Ertapenem Bupivacaine Erythromycin Cisatracurium Ethambutol Desflurane Ethionamide Dexmedetomidine Flucloxacillin Enflurane Gentamicin Ephedrine Imipenem/Cilastatin Halothane Isoniazid Isoflurane Kanamycin Ketamine Levofloxacin Linezolid Nitrous oxide Meropenem Propofol Metronidazole Rocuronium Moxifloxacin Sevoflurane Nitrofurantoin Sufentanil Ofloxacin Suxamethonium (succinylcholine) Para-aminosalicylic acid Tetracaine Penicillins Thiopental for distribution. for Pyrazinamide Tizanidine Rifabutin Vecuronium Rifampicin Analgesics Rifapentine Alfentanil Rifaximin Aspirin Spectinomycin Buprenorphine Streptomycin Celecoxib Sulfadiazine Codeine Telithromycin Tetracyclines Dextropropoxyphene Trimethoprim/Sulfamethoxazole Diamorphine (diacetylmorphine) Vancomycin Diclofenac Dihydrocodeine Anti-coagulant, Anti-platelet and Fibrinolytic Fentanyl Acenocoumarol Apixaban Hydrocodone Aspirin (anti-platelet) Hydromorphone Clopidogrel Ibuprofen Dabigatran Mefenamic acid Dalteparin Methadone Dipyridamole Morphine Edoxaban Naproxen Not only. use For personal distribution. Eltrombopag Nimesulide Enoxaparin Oxycodone Fondaparinux Paracetamol (Acetaminophen) Heparin Pethidine (Meperidine) Phenprocoumon Piroxicam Prasugrel Tramadol Rivaroxaban Streptokinase Anthelmintics Albendazole Ticagrelor Diethylcarbamazine Warfarin Ivermectin Anticonvulsants Levamisole (Ergamisol) Carbamazepine Mebendazole Clonazepam Niclosamide Ethosuximide Oxamniquine Gabapentin Lacosamide Praziquantel Lamotrigine Pyrantel Levetiracetam Suramin sodium Oxcarbazepine Triclabendazole Phenobarbital (Phenobarbitone) Antiarrhythmics Phenytoin Amiodarone Pregabalin Bepridil Topiramate Disopyramide Valproate (Divalproex) Dofetilide Vigabatrin Flecainide Zonisamide Lidocaine (Lignocaine) Antidepressants Mexiletine Agomelatine Propafenone Amitriptyline Quinidine Bupropion Citalopram Antibacterials Amikacin Clomipramine Desipramine Amoxicillin Doxepin Ampicillin Duloxetine Azithromycin Escitalopram Bedaquiline Fluoxetine Capreomycin for Not only. use For personal for distribution. Not only. use For personal Fluvoxamine Cefalexin Imipramine Cefazolin Lithium Cefixime Maprotiline Cefotaxime Mianserine Ceftazidime Milnacipran Ceftriaxone Mirtazapine Chloramphenicol Nefazodone Ciprofloxacin Nortriptyline Clarithromycin Paroxetine Clavulanic acid Phenelzine Clindamycin Reboxetine Clofazimine Sertraline Cloxacillin Tranylcypromine Cycloserine Trazodone Dapsone Trimipramine Doxycycline Venlafaxine Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and ATV Atazanavir (Reyataz®) IDV Indinavir (Crixivan®) These drugs should not be coadministered unboosted regimens, the charts reflect the more cautious option. Potential interaction – may require close monitoring, ® Cobi Cobicistat (Tybost®) LPV Lopinavir (Kaletra ) alteration of drug dosage or timing of administration © Liverpool Drug Interaction Group, University of Liverpool Potential interaction likely to be of weak intensity. Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF ® ® Additional action/monitoring or dosage adjustment is DRV Darunavir (Prezista ) RTV Ritonavir (Norvir ) We aim to ensure that information is accurate and consistent with current knowledge unlikely to be required ® and practice. However, the University of Liverpool and its servants or agents shall not Fosamprenavir SQV Saquinavir (Invirase ) No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this FPV ® ® publication whether arising from negligence or otherwise howsoever or for any (Telzir , Lexiva ) TPV Tipranavir (Aptivus®) There are no clear data, actual or theoretical, to indicate consequences arising therefrom. The University of Liverpool expressly exclude whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law. www.hiv-druginteractions.org Interactions with Protease Inhibitors Charts revised February 2018. Full information available at www.hiv-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. ATV Cobi DRV FPV IDV LPV RTV SQV TPV ATV Cobi DRV FPV IDV LPV RTV SQV TPV Anti-diabetics Antipsychotics/Neuroleptics Acarbose Amisulpride Empagliflozin Aripiprazole Exanatide Asenapine Chlorpromazine Glibenclamide (Glyburide) Clozapine Gliclazide Fluphenazine Glimepiride Haloperidol Glipizide Iloperidone Insulin Levomepromazine Linagliptin Olanzapine Liraglutide Paliperidone Perazine Metformin Periciazine Nateglinide Perphenazine Pioglitazone Pimozide Repaglinide Pipotiazine Rosiglitazone Quetiapine Saxagliptin distribution. for Risperidone Sulpiride Sitagliptin Thioridazine Tolbutamide Tiapride Vildagliptin Ziprasidone Antifungals Zotepine Amphotericin B Zuclopenthixol Anidulafungin Antivirals Caspofungin Aciclovir Fluconazole Adefovir Amantadine Flucytosine Boceprevir Griseofulvin Cidofovir Itraconazole Daclatasvir Ketoconazole Elbasvir/Grazoprevir Miconazole Entecavir Nystatin Famciclovir Posaconazole Foscarnet Ganciclovir Terbinafine Glecaprevir/Pibrentasvir distribution. For personal use only. Not Not only. use For personal distribution. Voriconazole Ledipasvir/Sofosbuvir Antihistamines Ombitasvir/Paritaprevir/r Astemizole Ombitasvir/Paritaprevir/r + Dasabuvir Cetirizine Oseltamivir Chlorphenamine Ribavirin Diphenhydramine Rimantadine Simeprevir Fexofenadine Sofosbuvir Levocetirizine Sofosbuvir/Velpatasvir Loratadine Sofosbuvir/Velpatasvir/Voxilaprevir Promethazine Telaprevir Terfenadine Telbivudine Valaciclovir Antimigraine Agents Almotriptan Zanamivir Dihydroergotamine Anxiolytics/Hypnotics/Sedatives Alprazolam Ergotamine Bromazepam Rizatriptan Buspirone Sumatriptan Chlordiazepoxide Antiprotozoals Clorazepate Amodiaquine Diazepam Artemisinin Estazolam Atovaquone Flunitrazepam Flurazepam Benznidazole Hydroxyzine Chloroquine Lorazepam Diloxanide Lormetazepam Eflornithine Midazolam (oral) Halofantrine Midazolam (parenteral) Lumefantrine Oxazepam Temazepam Mefloquine Triazolam Meglumine antimoniate Zaleplon Melarsoprol Zolpidem Miltefosine for Not only. use For personal for distribution. Not only. use For personal Zopiclone Nifurtimox Beta Blockers Paromomycin Atenolol Pentamidine Bisoprolol Primaquine Carvedilol Proguanil Metoprolol Nebivolol Pyrimethamine Oxprenolol Quinine .
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