Pantesin® Pantethine a Clinically-Researched, Ultra-Pure Ingredient That Supports Healthy Cholesterol Levels*

Pantesin® Pantethine A clinically-researched, ultra-pure ingredient that supports healthy cholesterol levels*

What is pantethine? A derivative of B5, pantethine is composed of two molecules of pantothenic acid linked by cysteamine bridging groups.

What does pantethine do? Pantethine helps increase the metabolic activity of Coenzyme A (CoA) and the acyl-carrier protein (ACP), which creates a reduction in cholesterol synthesis.*

What is Pantesin® Pantethine? A branded form of Pantethine with 35+ years of research supporting its positive effect on cholesterol levels in high-risk CVD subjects.*

Study results on Pantesin® Pantethine

Research on the effectiveness of pantethine1

An overview of all published studies Serum lipid changes HDL LDL Triglycerides from 1966-2002 on subjects with 20 10 abnormally elevated lipid levels 0 who were given an average of -10 -20 Results at 4 months: 900 mg/day of Pantesin®. -30 8% increase in HDL (good) cholesterol*

% Change from baseline % Change from -40 20% decrease in LDL (bad) cholesterol* B Month 1 Month 2 Month 3 Month 4 33% decrease in Triglycerides*

Two studies on low to moderate-CVD risk individuals For both studies subjects consumed the U.S. National Institutes of Health heart healthy diet for four weeks to establish a baseline. The diet was then maintained throughout the following 16-week study period.

Pantesin® supplementation showed a significant improvement in blood lipid ratios over and above the heart healthy diet! Study #1 results2 Study #2 results3 After two weeks @ 600 mg/day of Pantesin® Low to moderate CVD risk subjects who were supplementation, low to moderate CVD risk eligible for statin therapy showed a significant subjects averaged a reduction of 3% in total decrease in total cholesterol, LDL (bad) cholesterol, 4% in LDL (bad) cholesterol, and cholesterol, and non-HDL cholesterol at 5% in Apo B — the main component of LDL. 16 weeks with Pantesin® supplementation.

Total Cholesterol Pantesin® Placebo Total Cholesterol Pantesin® Placebo 200 mg/dl 280 mg/dl 195 270 260 190 250 185 240

180 Decrease 3% Average 230 Decrease 6% Average Time (wks) S B 2 4 8 12 16 Time (wks) S B 2 4 8 12 16

LDL Cholesterol Pantesin® Placebo LDL Cholesterol Pantesin® Placebo 116 mg/dl 190 mg/dl 112 180 170 108 160 104 150

100 Decrease 4% Average 140 Decrease 11% Average Time (wks) S B 2 4 8 12 16 Time (wks) S B 2 4 8 12 16

Apolipoprotein B Pantesin® Placebo Non-LDL Cholesterol Pantesin® Placebo 95 mg/dl 220 mg/dl 210 200 90 190 180

85 Decrease 5% Average 170 Decrease 7% Average Time (wks) B 2 4 8 12 16 Time (wks) S B 2 4 8 12 16

Results also showed*: • No additional measureable benefits when Pantesin was increased from 600 to 900 mg/day for weeks 9-16 • No statistical difference in subjects blood CoQ10 levels • No significant adverse events compared to placebo

Conclusion: Pantesin® @ 600mg/day produced a significant decrease in total cholesterol and LDL over and above the effects of a heart healthy diet.* This suggests that Pantesin® can be a smart addition for individuals looking for help to maintain healthy blood lipid levels.*

1. McRae MP et. al., Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efﬁcacy and tolerability, Nutrition Research, 25: 319-333, 2005 2. Rumberger JA et al., Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011 Aug 31. 3. Evans M. et al., Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014 Feb 27.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. To find brands with Pantesin® Pantethine in their formulation Pantesin® is a registered trademark of Kyowa Pharma Chemical Co., Ltd. Copyright ©2016 KYOWA HAKKO U.S.A., INC. All Rights Reserved. R-5.18.16 or to learn more, visit: www.pantesin.com