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1111111111111111111Imnumu 1111111111111111111imnumu (12) United States Patent (1o) Patent No.: US 9,005,185 B2 Ferrari et al. (45) Date of Patent: Apr. 14, 2015 (54) NANOCHANNELED DEVICE AND RELATED (52) U.S. Cl. METHODS CPC .............. A61M37/00(2013.01);A61K910097 (2013.01); B81C1100119 (2013.01); B82Y5100 (71) Applicants: The Board of Regents of the University (2013.01); A61M 5114276 (2013.01); B81B of Texas System, Austin, TX (US); The 22011058 (2013.01); B81B 220310338 Ohio State University Research (2013.01) Foundation, Columbus, OH (US) (58) Field of Classification Search CPC . A61M 5/14276; A61M 5/141; A61M 37/00; (72) Inventors: Mauro Ferrari, Houston, TX (US); A61 M 2209/045; A61 M 2039/0264; A61 M 2039/0291; A61F 2250/0068; A61K 9/0097; Xuewu Liu, Sugar Land, TX (US); 138113 2201/058; 138113 2203/0338 Alessandro Grattoni, Houston, TX USPC ........ 604/246, 288.01, 288.02, 288.04, 891.1 (US); Randy Goodall, Austin, TX (US); See application file for complete search history. Lee Hudson, Elgin, TX (US) (56) References Cited (73) Assignees: The Board of Regents of the University of Texas System, Austin, TX (US); The U.S. PATENT DOCUMENTS Ohio State University Research Foundation, Columbus, OH (US) 3,731,681 A 5/1973 Blackshear et al. 3,921,636 A 11/1975 Zaffaroni (*) Notice: Subject to any disclaimer, the term of this (Continued) patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. FOREIGN PATENT DOCUMENTS (21) Appl. No.: 14/099,429 DE 10 2006 014476 7/2007 EP 1 977 775 10/2008 (22) Filed: Dec. 6, 2013 (Continued) (65) Prior Publication Data OTHER PUBLICATIONS US 2014/0180251 Al Jun. 26, 2014 "The Economic Costs of Drug Abuse in the United States," www. whitehousedrugpolicy.gov, Sep. 2001. (Continued) Related U.S. Application Data (63) Continuation of application No. 13/264,069, filed as Primary Examiner Nicholas Lucchesi application No. PCT/US2010/030937 on Apr. 13, Assistant Examiner Gerald Landry, II 2010, now Pat. No. 8,632,510, which is a (74) Attorney, Agent, or Firm Parker Highlander PLLC (Continued) (57) ABSTRACT (51) Int. Cl. A capsule configured for in vivo refilling of a therapeutic A61K9122 (2006.01) agent. In certain embodiments, the capsule may contain A61M37100 (2006.01) methotrexate. (Continued) 14 Claims, 39 Drawing Sheets 636 1624 11 .- 1634 1616 11 , 1 626 1650 1614 1613 1 '1 1602 1600 US 9,005,185 B2 Page 2 Related U.S. Application Data OTHER PUBLICATIONS "Under the Counter: The Diversion and Abuse of Controlled Pre- continuation-in-part of application No. 12/618,233, scription Drugs in the US," The National Center on Addiction and filed on Nov. 13, 2009, now Pat. No. 8,480,637. Substance Abuse (CASA) at Columbia University, New York, NY, (60) Provisional application No. 61/168,844, filed on Apr. CASA, Jul. 2005. 13, 2009, provisional application No. 61/114,687, Christensen et al., "Tantalum oxide thin films as protective coatings filed on Nov. 14, 2008. for sensors," J. Micromech. Microeng., 9:113-118, 1999. Extended European Search Report issued in European Application (51) Int. Cl. No. 10765046, mailed Oct. 1, 2012. A61K9/00 (2006.01) Extended European Search Report issued in European Application B81C1/00 (2006.01) No. 09826831, mailed Jul. 12, 2012. B82Y5100 (2011.01) Fine et al., "A robust nanofiuidic membrane with tunable zero-order release for implantable dose specific drug delivery," Lab on a Chip, A61M51142 (2006.01) 10(2): 3074-3083, 2010. Hammerle et al., `Biostability of micro-photodiode arrays for (56) References Cited subretinal implantation," Biomaterials., 23:797-804, 2002. U.S. PATENT DOCUMENTS Hess et al., "PECVD silicon carbide as athin filmpackaging material for microfabricated neural electrodes," Mater. Res. Soc. Symp. Proc., 4,834,704 A 5/1989 Reinicke 1009-U04-03, 2007. 4,955,861 A 9/1990 Enegren et al. Narayan et al., "Mechanical and biological properties of nanoporous 5,085,656 A * 2/1992 Polaschegg ............. 604/891.1 carbon membranes," Biomed. Mater., 3:034107, 2008. 5,395,324 A 3/1995 Hinrichs et al. 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WO WO 2010/056986 5/2010 WO WO 2010/120817 10/2010 * cited by examiner U.S. Patent Apr. 14, 2015 Sheet 1 of 39 US 9,005,185 B2 *i M 3'`C~~ `✓ _ 7 i ;i Q V-ft ^ep~Paad C6: e °pia Nz F~ 11 1 l cm iz °ape 3 3j1> i U- 1 U.S. Patent Apr. 14 , 2015 Sheet 2 of 39 US 9,005,185 B2 10 15 FIG. 2A 10 --"~ 15 " P~ 25 F1.2 U.S. Patent Apr. 14, 2015 Sheet 3 of 39 US 9,005,185 B2 10 15 25 FIG. 2C 25 20 FIG. 2D U.S. Patent Apr. 14, 2015 Sheet 4 of 39 US 9,005,185 B2 25 20 FIG. 2E U.S. Patent Apr. 14, 2015 Sheet 5 of 39 US 9,005,185 B2 FIG. 3B FIG. 3C U.S. Patent Apr. 14, 2015 Sheet 6 of 39 US 9,005,185 B2 of 60 70 25 20 40 F1.3 U.S. Patent Apr. 14, 2015 Sheet 7 of 39 US 9,005,185 B2 20 *-40 FIG. 3E 20 FIG. 3F U.S. Patent Apr. 14, 2015 Sheet 8 of 39 US 9,005,185 B2 FIG. 3G U.S. Patent Apr. 14, 2015 Sheet 9 of 39 US 9,005,185 B2 3 cm a i - u r µ t' r CZ CI ! i`3t kti1 j~ I X } } . i f r cz a y s U.S.
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