1111111111111111111imnumu (12) United States Patent (1o) Patent No.: US 9,005,185 B2 Ferrari et al. (45) Date of Patent: Apr. 14, 2015 (54) NANOCHANNELED DEVICE AND RELATED (52) U.S. Cl. METHODS CPC .............. A61M37/00(2013.01);A61K910097 (2013.01); B81C1100119 (2013.01); B82Y5100 (71) Applicants: The Board of Regents of the University (2013.01); A61M 5114276 (2013.01); B81B of Texas System, Austin, TX (US); The 22011058 (2013.01); B81B 220310338 Ohio State University Research (2013.01) Foundation, Columbus, OH (US) (58) Field of Classification Search CPC . A61M 5/14276; A61M 5/141; A61M 37/00; (72) Inventors: Mauro Ferrari, Houston, TX (US); A61 M 2209/045; A61 M 2039/0264; A61 M 2039/0291; A61F 2250/0068; A61K 9/0097; Xuewu Liu, Sugar Land, TX (US); 138113 2201/058; 138113 2203/0338 Alessandro Grattoni, Houston, TX USPC ........ 604/246, 288.01, 288.02, 288.04, 891.1 (US); Randy Goodall, Austin, TX (US); See application file for complete search history. 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WO WO 2010/056986 5/2010 WO WO 2010/120817 10/2010 * cited by examiner U.S. Patent Apr. 14, 2015 Sheet 1 of 39 US 9,005,185 B2 *i M 3'`C~~ `✓ _ 7 i ;i Q V-ft ^ep~Paad C6: e °pia Nz F~ 11 1 l cm iz °ape 3 3j1> i U- 1 U.S. Patent Apr. 14 , 2015 Sheet 2 of 39 US 9,005,185 B2 10 15 FIG. 2A 10 --"~ 15 " P~ 25 F1.2 U.S. Patent Apr. 14, 2015 Sheet 3 of 39 US 9,005,185 B2 10 15 25 FIG. 2C 25 20 FIG. 2D U.S. Patent Apr. 14, 2015 Sheet 4 of 39 US 9,005,185 B2 25 20 FIG. 2E U.S. Patent Apr. 14, 2015 Sheet 5 of 39 US 9,005,185 B2 FIG. 3B FIG. 3C U.S. Patent Apr. 14, 2015 Sheet 6 of 39 US 9,005,185 B2 of 60 70 25 20 40 F1.3 U.S. Patent Apr. 14, 2015 Sheet 7 of 39 US 9,005,185 B2 20 *-40 FIG. 3E 20 FIG. 3F U.S. Patent Apr. 14, 2015 Sheet 8 of 39 US 9,005,185 B2 FIG. 3G U.S. Patent Apr. 14, 2015 Sheet 9 of 39 US 9,005,185 B2 3 cm a i - u r µ t' r CZ CI ! i`3t kti1 j~ I X } } . i f r cz a y s U.S.