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(12) Patent Application Publication (10) Pub. No.: US 2013/0034530 A1 Fantz (43) Pub
US 2013 0034530A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0034530 A1 Fantz (43) Pub. Date: Feb. 7, 2013 (54) DIETARY SUPPLEMENT COGNITIVE (52) U.S. Cl. ....................................... 424/94.2; 424/643 SUPPORT SYSTEM (57) ABSTRACT (75) Inventor: David Robert Fantz, Denver, CO (US) The present invention relates to a nutritional Supplement composition, comprising a therapeutically effective amounts of Vitamin C, Vitamin D3. Thiamin, Riboflavin, Niacin, Vita (73) Assignee: David R. Fantz, Denver, CO (US) min B6, Folic acid, Vitamin B12, Pantothenic acid, Calcium, Magnesium, Zinc, Chromium, Sugar, Protein, Acetyl-L-Car (21) Appl. No.: 13/456,287 nitine, Dimethylaminoethanol complex, Phosphatidylserine complex, L-Glutamine, N-Acetyl-L-Tyrosine, L-Phenylala nine, Taurine, Methionine, Valine, Isoleucine, 5 Hydrox (22) Filed: Apr. 26, 2012 ytryptophan, L-Taurine, N-Acetyl-Tyrosine, N-Acetyl-L- Cysteine, Alpha Lipoic Acid, Alpha Related U.S. Application Data Glycerylphosphoricholine complex, Bacopa Monnieri extract, Gingko Biloba extract, Passion flower, Lemon Balm, (60) Provisional application No. 61/480.372, filed on Apr. Gotu Kola, Ashwagandha, Choline Bitartrate complex, Panax 29, 2011. Ginseng extract, Turmeric, Organic freeze dried fruit juice blends (concord grape, red raspberry, pineapple, cranberry, Publication Classification acai, pomegranate, acerola cherry, bilberry, lingonberry, black currant, aronia, Sour cherry, black raspberry), Organic (51) Int. Cl. freeze dried greens blends (barley grass, broccoli, beet, car A6 IK33/30 (2006.01) rot, alfalfa, oat), and Protein digestive enzyme blends (Pro A6IP3/02 (2006.01) tease 4.5, peptidase, bromelain, protease 6.0, protease 3.0, L A6IP 25/00 (2006.01) planatrum, B bifidum) in a mixture to provide optimal cog A6 IK38/54 (2006.01) nitive function. -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110449 A1 Lorber Et Al
US 200601 10449A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110449 A1 LOrber et al. (43) Pub. Date: May 25, 2006 (54) PHARMACEUTICAL COMPOSITION Publication Classification (76) Inventors: Richard R. Lorber, Scotch Plains, NJ (US); Heribert W. Staudinger, Union, (51) Int. Cl. NJ (US); Robert E. Ward, Summit, NJ A6II 3/473 (2006.01) (US) A6II 3L/24 (2006.01) Correspondence Address: A6IR 9/20 (2006.01) SCHERING-PLOUGH CORPORATION (52) U.S. Cl. ........................... 424/464; 514/290: 514/540 PATENT DEPARTMENT (K-6-1, 1990) 2000 GALLOPNG HILL ROAD KENILWORTH, NJ 07033-0530 (US) (57) ABSTRACT (21) Appl. No.: 11/257,348 (22) Filed: Oct. 24, 2005 The present invention relates to formulations useful for Related U.S. Application Data treating respiratory disorders associated with the production of mucus glycoprotein, skin disorders, and allergic conjunc (60) Provisional application No. 60/622,507, filed on Oct. tivitis while substantially reducing adverse effects associ 27, 2004. Provisional application No. 60/621,783, ated with the administration of non-selective anti-cholin filed on Oct. 25, 2004. ergic agents and methods of use thereof. US 2006/01 10449 A1 May 25, 2006 PHARMACEUTICAL COMPOSITION example, Weinstein and Weinstein (U.S. Pat. No. 6,086,914) describe methods of treating allergic rhinitis using an anti CROSS REFERENCE TO RELATED cholinergic agent with a limited capacity to pass across lipid APPLICATION membranes, such as the blood-brain barrier, in combination with an antihistamine that is limited in both sedating and 0001. This application claims benefit of priority to U.S. -
Vitamins Minerals Nutrients
vitamins minerals nutrients Vitamin B12 (Cyanocobalamin) Snapshot Monograph Vitamin B12 Nutrient name(s): (Cyanocobalamin) Vitamin B12 Most Frequent Reported Uses: Cyanocobalamin • Homocysteine regulation Methylcobalamin • Neurological health, including Adenosylcobalamin (Cobamamide) diabetic neuropathy, cognitive Hydroxycobalamin (European) function, vascular dementia, stroke prevention • Anemias, including pernicious and megaloblastic • Sulfite sensitivity Cyanocobalamin Introduction: Vitamin B12 was isolated from liver extract in 1948 and reported to control pernicious anemia. Cobalamin is the generic name of vitamin B12 because it contains the heavy metal cobalt, which gives this water-soluble vitamin its red color. Vitamin B12 is an essential growth factor and plays a role in the metabolism of cells, especially those of the gastrointestinal tract, bone marrow, and nervous tissue. Several different cobalamin compounds exhibit vitamin B12 activity. The most stable form is cyanocobalamin, which contains a cyanide group that is well below toxic levels. To become active in the body, cyanocobalamin must be converted to either methylcobalamin or adenosylcobalamin. Adenosylcobalamin is the primary form of vitamin B12 in the liver. © Copyright 2013, Integrative Health Resources, LLC | www.metaboliccode.com A protein in gastric secretions called intrinsic factor binds to vitamin B12 and facilitates its absorption. Without intrinsic factor, only a small percentage of vitamin B12 is absorbed. Once absorbed, relatively large amounts of vitamin B12 can be stored in the liver. The body actually reabsorbs vitamin B12 in the intestines and returns much of it to the liver, allowing for very little to be excreted from the body. However, when there are problems in the intestines, such as the microflora being imbalanced resulting in gastrointestinal inflammation, then vitamin B12 deficiencies can occur. -
Optimal Foods
Optimal Foods 1. Almonds: high in monounsaturated and polyunsaturated fats, with 20% of calories coming from protein and dietary fiber. Nutrients include potassium, magnesium, calcium, iron, zinc, vitamin E and an antioxidant flavonoid called amygdlin also known as laetrile. 2. Barley: Like oat bran it is high in beta-glucan fiber which helps to lower cholesterol. Nutrients include copper, magnesium, phosphorous and niacin. 3. Berries : The darker the berry the higher in anti-oxidants. Nutritionally they are an excellent source of flavonoids, especially anthocyanidins, vitamin C and both soluble and insoluble fiber. 4. Brussels Sprouts : Similar to broccoli, and a member of the cabbage family, it contains cancer fighting glucosinolates. Nutritionally it is an excellent source of vitamin C and K, the B vitamins, beta-carotene, potassium and dietary fiber. 5. Carrots: It contains the highest source of proviatamin A carotenes as well as vitamin K, biotin, vitamin C, B6, potassium, thiamine and fiber. 6. Dark Chocolate: It is rich in the flavonoids, similar to those found in berries and apples, that are more easily absorbed than in other foods. It also provides an amino acid called arginine that helps blood vessels to dilate hence regulating blood flow and helping to lower blood pressure. Choose high-quality semisweet dark chocolate with the highest cocoa content that appeals to your taste buds. 7. Dark leafy greens : Kale, arugula, spinach, mustard greens, chard, collards, etc: low calorie, anti-oxidant dense food with carotenes, vitamin C, folic acid, manganese, copper, vitamin E, copper, vitamin B6, potassium, calcium, iron and dietary fiber. Kale is a particularly excellent bioavailable source of calcium while spinach is not. -
The Role of Nutritional Therapies in the Care Of
© Michael Ash BSc DO ND F.DipION 2010 4/29/2010 'The role of Nutritional Therapy in the care of individuals with cardiovascular related problems' Michael Ash BSc (Hons) DO ND F DipION mBANT NTCC Osteopath Naturopath Nutritional Therapist Researcher Author Nutritional Therapy • A Functional Medicine approach to optimise outcomes, ease of engagement and compliance. • 8 Practical strategies & how to avoid common pitfalls. • Interaction of the immune system with the heart. • GastroCentric Perspective. • How food selection can provide a multi faceted benefit. • Supplements of benefit. 1 © Michael Ash BSc DO ND F.DipION 2010 4/29/2010 Client Overview Goals Determine their aims and outcomes – the purpose of the plan is to support the patients goals with evidence based strategies Identify realistic goals, obtain agreement that these are achievable and describe plan ASSESMENT ANTECEDENTS TRIGGERS Medical history review and systems analysis assess the: MEDIATORS Antecedents: Sex, Age, Genetics, Lifestyle, Experiences, Trauma, Childhood, Stress, etc. Triggers: Events that initiate illness or symptoms – stress, infection, environmental toxins, food. etc. – look to see if they can be removed or controlled Mediators: Cytokines, prostaglandins, free radicals, neurotransmitters, fear, personal value, behavioural conditioning, poverty, etc. Evolutionary Nutritional Therapy • In physiology, foetal nutritional stress appears to flip an evolved switch that sets the body into a state that protects against starvation. • When these individuals encounter modern diets, they respond with the deadly metabolic syndrome of obesity, hypertension, and diabetes. • Barker DJ, Eriksson JG, Forsén T, Osmond C.Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002 Dec;31(6):1235-9. -
Toxicological and Pharmacological Profile of Amanita Muscaria (L.) Lam
Pharmacia 67(4): 317–323 DOI 10.3897/pharmacia.67.e56112 Review Article Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine Maria Voynova1, Aleksandar Shkondrov2, Magdalena Kondeva-Burdina1, Ilina Krasteva2 1 Laboratory of Drug metabolism and drug toxicity, Department “Pharmacology, Pharmacotherapy and Toxicology”, Faculty of Pharmacy, Medical University of Sofia, Bulgaria 2 Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria Corresponding author: Magdalena Kondeva-Burdina ([email protected]) Received 2 July 2020 ♦ Accepted 19 August 2020 ♦ Published 26 November 2020 Citation: Voynova M, Shkondrov A, Kondeva-Burdina M, Krasteva I (2020) Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine. Pharmacia 67(4): 317–323. https://doi.org/10.3897/pharmacia.67. e56112 Abstract Amanita muscaria, commonly known as fly agaric, is a basidiomycete. Its main psychoactive constituents are ibotenic acid and mus- cimol, both involved in ‘pantherina-muscaria’ poisoning syndrome. The rising pharmacological and toxicological interest based on lots of contradictive opinions concerning the use of Amanita muscaria extracts’ neuroprotective role against some neurodegenerative diseases such as Parkinson’s and Alzheimer’s, its potent role in the treatment of cerebral ischaemia and other socially significant health conditions gave the basis for this review. Facts about Amanita muscaria’s morphology, chemical content, toxicological and pharmacological characteristics and usage from ancient times to present-day’s opportunities in modern medicine are presented. Keywords Amanita muscaria, muscimol, ibotenic acid Introduction rica, the genus had an ancestral origin in the Siberian-Be- ringian region in the Tertiary period (Geml et al. -
The Effect of Vitamin Supplementation on Subclinical
molecules Review The Effect of Vitamin Supplementation on Subclinical Atherosclerosis in Patients without Manifest Cardiovascular Diseases: Never-ending Hope or Underestimated Effect? Ovidiu Mitu 1,2,* , Ioana Alexandra Cirneala 1,*, Andrada Ioana Lupsan 3, Mircea Iurciuc 4 , 5 5 2, Ivona Mitu , Daniela Cristina Dimitriu , Alexandru Dan Costache y , Antoniu Octavian Petris 1,2 and Irina Iuliana Costache 1,2 1 Department of Cardiology, Clinical Emergency Hospital “Sf. Spiridon”, 700111 Iasi, Romania 2 1st Medical Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania 3 Department of Cardiology, University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania 4 Department of Cardiology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, Romania 5 2nd Morpho-Functional Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania * Correspondence: [email protected] (O.M.); [email protected] (I.A.C.); Tel.: +40-745-279-714 (O.M.) Medical Student, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania. y Academic Editors: Raluca Maria Pop, Ada Popolo and Stefan Cristian Vesa Received: 25 March 2020; Accepted: 7 April 2020; Published: 9 April 2020 Abstract: Micronutrients, especially vitamins, play an important role in the evolution of cardiovascular diseases (CVD). It has been speculated that additional intake of vitamins may reduce the CVD burden by acting on the inflammatory and oxidative response starting from early stages of atherosclerosis, when the vascular impairment might still be reversible or, at least, slowed down. The current review assesses the role of major vitamins on subclinical atherosclerosis process and the potential clinical implications in patients without CVD. -
The Efficacy of Pantothenic Acid As a Modifier of Body Composition in a Porcine Model of Obesity Development
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1-1-2004 The efficacy of pantothenic acid as a modifier of body composition in a porcine model of obesity development Carey Ann Baldwin Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Recommended Citation Baldwin, Carey Ann, "The efficacy of pantothenic acid as a modifier of body composition in a porcine model of obesity development" (2004). Retrospective Theses and Dissertations. 20349. https://lib.dr.iastate.edu/rtd/20349 This Thesis is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. The efficacy of pantothenic acid as a modifier of body composition in a porcine model of obesity development by Carey Ann Baldwin A thesis submitted to the graduate faculty in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Major: Animal Nutrition Program of Study Committee: Tim Stahly, Major Professor Paul Flakoll Chad Stahl Iowa State University Ames, Iowa 2004 Copyright© Carey Ann Baldwin, 2004. All rights reserved. 11 Graduate College Iowa State University This is to certify that the master's thesis of Carey Ann Baldwin has met the thesis requirements of Iowa State University Signatures have been redacted for privacy 111 TABLE OF CONTENTS ACKNOWLEDGEMENTS Vl ABSTRACT Vll CHAPTER 1. GENERAL INTRODUCTION 1 Introduction 1 Thesis Organization 2 Literature Cited 2 CHAPTER 2. -
Vitamin and Mineral Safety 3Rd Edition (2013) Council for Responsible Nutrition (CRN)
EXCERPTED FROM: Vitamin and Mineral Safety 3rd Edition (2013) Council for Responsible Nutrition (CRN) www.crnusa.org Vitamin B12 Introduction Vitamin B12 helps maintain the body’s nervous system and blood cells and supports the production of DNA. Vitamin B12 also helps prevents a type of anemia and has been termed the “anti-pernicious anemia dietary factor.” Vitamin B12 is also the only known physiologically important compound that contains cobalt, and therefore the various forms of vitamin B12 are known collectively as cobalamins. Vitamin B12 is a cofactor in two enzymes that are fundamental in facilitating growth in humans. In the methylcobalamin form, vitamin B12 is the direct cofactor for methionine synthetase, the enzyme that recycles homocysteine back to methionine. Here, vitamin B12 and folic acid have closely related roles in one-carbon metabolism. In the adenosylcobalamin form, vitamin B12 is the cofactor in methylmalonyl-coenzyme A mutase. Both reactions are involved in promoting the rapid growth and proliferation of bone marrow cells and ultimately red blood cells (Expert Group on Vitamins and Minerals [EVM] 2003). Vitamin B12 is essential for the function and maintenance of the central nervous system, and severe deficiency in persons with pernicious anemia produces the neurological disease of posterolateral spinal cord degeneration (Herbert and Das 1994). The direct cause of pernicious anemia, in fact, is vitamin B12 deficiency, but the underlying defect is the absence of an intrinsic factor produced by specific stomach cells and needed for intestinal absorption of vitamin B12. Without this intrinsic factor, absorption is greatly reduced or fails, and a severe and persistent deficiency develops that is not preventable by the usual dietary levels of vitamin B12. -
Role of Amylase in Ovarian Cancer Mai Mohamed University of South Florida, [email protected]
University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School July 2017 Role of Amylase in Ovarian Cancer Mai Mohamed University of South Florida, [email protected] Follow this and additional works at: http://scholarcommons.usf.edu/etd Part of the Pathology Commons Scholar Commons Citation Mohamed, Mai, "Role of Amylase in Ovarian Cancer" (2017). Graduate Theses and Dissertations. http://scholarcommons.usf.edu/etd/6907 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. Role of Amylase in Ovarian Cancer by Mai Mohamed A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Pathology and Cell Biology Morsani College of Medicine University of South Florida Major Professor: Patricia Kruk, Ph.D. Paula C. Bickford, Ph.D. Meera Nanjundan, Ph.D. Marzenna Wiranowska, Ph.D. Lauri Wright, Ph.D. Date of Approval: June 29, 2017 Keywords: ovarian cancer, amylase, computational analyses, glycocalyx, cellular invasion Copyright © 2017, Mai Mohamed Dedication This dissertation is dedicated to my parents, Ahmed and Fatma, who have always stressed the importance of education, and, throughout my education, have been my strongest source of encouragement and support. They always believed in me and I am eternally grateful to them. I would also like to thank my brothers, Mohamed and Hussien, and my sister, Mariam. I would also like to thank my husband, Ahmed. -
The Absorption of Radioactive Sulphur -Labelled in Patients with Intestinal
TITLE: The absorption of Radioactive Sulphur-labelled Thiamine Hydrochloride in Control Subjects and in Patients with Intestinal Malabsorption. SHORT TITI : A test for the Absorption of Thiamine in Man AUTHOR: A.D. THOMSON DEPARTMENT: From the University Department of Therapeutics, Royal Infirmary, Edinburgh. A Test for the Absorption of Thiamine in Man SUMMARY: (1) A method is described for investigating vitamin B1 absorption in man by measuring the urinary radioactivity during the 24 hours following an oral dose of radioactive 35S- thiamine which is given along with a parentergl injection of non-radioactive thiamine hydrochloride. (2) Analysis of small intestinal juice and characterisation of radioactive material in the urine indicate that the urine contains radioactive thiamine which was unchanged prior to absorption. (3) In control subjects, the major period of thiamine absorption occurred within the first 2 hours and practically all of the oral dose absorbed was excreted during the first 211. hours. (4) Eight patients with untreated primary malabsorptive disease (idiopathic steatorrhoea) showed a mean urinary excretion of radioactive thiamine sig- nificantly less than in the control group. The rate of excretion was markedly reduced but the period of maximal excretion occurred at approximately the same time as in control subjects. Thirteen patients with treated primary ma3absorp- tive disease showed no significant difference from the control group. (5) Ten patients who had undergone gastric surgery and two with resection of the terminal ileum excreted amounts which did not differ from the control group. Normal results were also found in four patients with pernicious anaemia. A Test for the Absorption of Thiamine in Man INTRODUCTION : Disease of the small intestine may cause impaired absorption of certain water -soluble vitamins. -
Essential Trace Elements in Human Health: a Physician's View
Margarita G. Skalnaya, Anatoly V. Skalny ESSENTIAL TRACE ELEMENTS IN HUMAN HEALTH: A PHYSICIAN'S VIEW Reviewers: Philippe Collery, M.D., Ph.D. Ivan V. Radysh, M.D., Ph.D., D.Sc. Tomsk Publishing House of Tomsk State University 2018 2 Essential trace elements in human health UDK 612:577.1 LBC 52.57 S66 Skalnaya Margarita G., Skalny Anatoly V. S66 Essential trace elements in human health: a physician's view. – Tomsk : Publishing House of Tomsk State University, 2018. – 224 p. ISBN 978-5-94621-683-8 Disturbances in trace element homeostasis may result in the development of pathologic states and diseases. The most characteristic patterns of a modern human being are deficiency of essential and excess of toxic trace elements. Such a deficiency frequently occurs due to insufficient trace element content in diets or increased requirements of an organism. All these changes of trace element homeostasis form an individual trace element portrait of a person. Consequently, impaired balance of every trace element should be analyzed in the view of other patterns of trace element portrait. Only personalized approach to diagnosis can meet these requirements and result in successful treatment. Effective management and timely diagnosis of trace element deficiency and toxicity may occur only in the case of adequate assessment of trace element status of every individual based on recent data on trace element metabolism. Therefore, the most recent basic data on participation of essential trace elements in physiological processes, metabolism, routes and volumes of entering to the body, relation to various diseases, medical applications with a special focus on iron (Fe), copper (Cu), manganese (Mn), zinc (Zn), selenium (Se), iodine (I), cobalt (Co), chromium, and molybdenum (Mo) are reviewed.