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(12) United States Patent (Io) Patent No.: US 9,526,824 B2 Ferrari Et Al

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(12) United States Patent (Io) Patent No.: US 9,526,824 B2 Ferrari Et Al 1111111111111111111111111111111111111111111111111111111111111111111111 (12) United States Patent (io) Patent No.: US 9,526,824 B2 Ferrari et al. (45) Date of Patent: Dec. 27, 2016 (54) NANOCHANNELED DEVICE AND RELATED (52) U.S. Cl. METHODS CPC .............. A61M 5/00 (2013.01); A61K 9/0097 (2013.01); A61M37/00 (2013.01); (71) Applicants:The Board of Regents of the (Continued) University of Texas System, Austin, TX (US); The Ohio State University (58) Field of Classification Search Research Foundation, Columbus, OH CPC ............. B81C 1/00444; B81C 1/00476; B81C (US) 1/00119; BO1D 67/0034; YIOS 148/05 (Continued) (72) Inventors: Mauro Ferrari, Houston, TX (US); Xuewu Liu, Sugar Land, TX (US); (56) References Cited Alessandro Grattoni, Houston, TX (US); Daniel Fine, Austin, TX (US); U.S. PATENT DOCUMENTS Randy Goodall, Austin, TX (US); Sharath Hosali, Austin, TX (US); 3,731,681 A 5/1973 Blackshear et al. Ryan Medema, Pflugerville, TX (US); 3,921,636 A 11/1975 Zaffaroni Lee Hudson, Elgin, TX (US) (Continued) (73) Assignees: The Board of Regents of the FOREIGN PATENT DOCUMENTS University of Texas System, Austin, TX (US); The Ohio State University CN 1585627 2/2005 Research Foundation, Columbus, OH DE 10 2006 014476 7/2007 (US) (Continued) (*) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS patent is extended or adjusted under 35 U.S.C. 154(b) by 784 days. "The Economic Costs of Drug Abuse in the United States," www. whitehousedrugpolicy.gov, Sep. 2001. (21) Appl. No.: 13/875,871 (Continued) (22) Filed: May 2, 2013 Primary Examiner Binh X Tran (65) Prior Publication Data (74) Attorney, Agent, or Firm Parker Highlander PLLC US 2013/0240483 Al Sep. 19, 2013 Related U.S. Application Data (57) ABSTRACT (63) Continuation of application No. 12/618,233, filed on A nanochannel delivery device and method of manufactur- Nov. 13, 2009, now Pat. No. 8,480,637. ing and use. The nanochannel delivery device comprises an (Continued) inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel (51) Int. Cl. delivery device. The inlet and outlet may be in direct fluid C23F 1/00 (2006.01) communication with the nanochannel. A61 5/00 (2006.01) (Continued) 22 Claims, 35 Drawing Sheets 280 ~X31 270 210 US 9,526,824 B2 Page 2 Related U.S. Application Data 2010/0077515 Al * 3/2010 Espinosa ............. B81C 1/00071 850/40 2010/0170796 Al * 7/2010 Bhatia ................... BOIL 3/5027 (60) Provisional application No. 61/168,844, filed on Apr. 204/453 13, 2009, provisional application No. 61/114,687, 2010/0212762 Al * 8/2010 Den Toonder ...... BO1F 13/0059 filed on Nov. 14, 2008. 137/803 2011/0137596 Al 6/2011 Grattoni et al. (51) Int. Cl. A61K 9/00 (2006.01) FOREIGN PATENT DOCUMENTS A61M 37/00 (2006.01) EP 1 977 775 10/2008 B81C 1/00 (2006.01) WO WO 00/74751 12/2000 B82Y5100 (2011.01) WO WO 2004/036623 4/2004 A61 51142 (2006.01) WO WO 2005/079387 9/2005 (52) U.S. Cl. WO WO 2006/113860 10/2006 WO WO 2007/047539 4/2007 CPC ............ B81C 1100119 (2013.01); B82Y5100 WO WO 2007/089483 8/2007 (2013.01); A61M 5114276 (2013.01); B81B WO WO 2008/019886 9/2008 22011058 (2013.01); B81B 220310338 WO WO 2009/149362 12/2009 (2013.01); Y1OT 13718593 (2015.04); Y1 OT WO WO 2010/056986 5/2010 WO WO 2010/120817 10/2010 15611064 (2015.01) (58) Field of Classification Search USPC ........................................... 216/2, 39, 41, 56 OTHER PUBLICATIONS See application file for complete search history. "Under the Counter: The Diversion and Abuse of Controlled Pre- scription Drugs in the US," The National Center on Addiction and (56) References Cited Substance Abuse (CASA) at Columbia University, New York, NY, U.S. PATENT DOCUMENTS CASA, Jul. 2005. Extended European Search Report issued in European Application 4,834,704 A 5/1989 Reinicke No. 09826831, mailed Jul. 12, 2012. 4,955,861 A 9/1990 Enegren et al. Nath et al., `Buprenorphine pharmacokinetics: relative bioavail- 5,085,656 A 2/1992 Polaschegg 5,395,324 A 3/1995 Hinrichs et al. ability of sublingual tablet and liquid formulations," J. Clin. 5,651,900 A 7/1997 Keller et al. Pharmacol., 39:619-623, 1999. 5,728,396 A 3/1998 Peery et al. Report Stakeholder Workshop on a National Buprenorphine Pro- 5,769,823 A 6/1998 Otto gram Health Canada Nov. 18, 2004. 5,770,076 A 6/1998 Chu et al. Samhsa, "Overview of Findings from the 2002 National Survey on 5,798,042 A 8/1998 Chu et al. Drug Use and Health," Rockville, MD, DHHS publication, SMA 5,893,974 A 4/1999 Keller et al. 03-3774. 5,938,923 A 8/1999 Tu et al. 5,948,164 A 9/1999 Iida et al. Samhsa, "Results from the 2003 National Survey on Drug Use and 5,948,255 A 9/1999 Keller et al. Health: National Findings," Rockeville, MD, DHHS publication, 5,985,164 A 11/1999 Chu et al. SMA 3-3964. 5,985,328 A 11/1999 Chu et al. Samhsa, "The DAWN Report: oxycodaone, hydrocodone, and 6,044,981 A 4/2000 Chu et al. polydrug use," 2002. Jul. 2004 http://oas.samhsa.gov/2k4/ 6,592,519 B1 7/2003 Martinez oxycodone/oxycodone.cfm. 7,025,871 B2 4/2006 Broadley et al. Office Action issued in Chinese Application No. 200980154070.X, 7,135,144 B2 11/2006 Christel et al. 7,326,561 B2 2/2008 Goodman et al. dated Jan. 7, 2013. (English Translation). 7,413,846 B2 8/2008 Maloney et al. Office Action issued in European Application No. 09826831, dated 7,955,614 B2 6/2011 Martin et al. Jul. 11, 2013. 8,480,637 B2 7/2013 Ferrari et al. Office Action issued in U.S. Appl. No. 12/618,233, mailed Apr. 27, 8,632,510 B2 1/2014 Ferrari et al. 2012. 9,005,185 B2 4/2015 Ferrari et al. Office Action issued in U.S. Appl. No. 12/618,233, mailed Oct. 16, 2002/0087120 Al 7/2002 Rogers et al. 2012. 2002/0156462 Al 10/2002 Stultz PCT International Preliminary Report on Patentability issued in 2003/0010638 Al 1/2003 Hansford et al. 2003/0064095 Al 4/2003 Martin et al. International Application No. PCT/US2009/064376, mailed May 2004/003 82 60 Al 2/2004 Martin et al. 26, 2011. 2004/0082908 Al 4/2004 Whitehurst et al. PCT International Search Report and Written Opinion issued in 2004/0116905 Al 6/2004 Pedersen et al. International Application No. PCT/US2009/064376, mailed Aug. 2004/0260418 Al 12/2004 Staats 23, 2010. 2004/0262159 Al 12/2004 Martin et al. Christensen et al., "Tantalum oxide thin films as protective coatings 2005/0118229 Al 6/2005 Boiarski for sensors," J. Micromech. Microeng., 9:113-118, 1999. 2006/0180469 Al 8/2006 Han et al. Extended European Search Report issued in European Application 2006/0191831 Al 8/2006 Hansford et al. No. 10765046, mailed Oct. 1, 2012. 2006/0259015 Al 11/2006 Steinbach Extended European Search Report issued in European Application 2006/0270983 Al 11/2006 Lord et al. No. 11784219.5, mailed Jul. 8, 2014. 2007/0066138 Al 3/2007 Ferrari et al. 2007/0077273 Al 4/2007 Martin et al. Fine et al.,"A robust nanofiuidic membrane with tunable zero-order 2007/0286773 Al 12/2007 Schlautmann et al. release for implantable dose specific drug delivery," Lab on a Chip, 2008/0073506 Al 3/2008 Lazar 10(2): 3074-3083, 2010. 2009/0181200 Al * 7/2009 Borenstein .......... B81C 1/00119 Hammerle et al., `Biostability of micro-photodiode arrays for 428/36.9 subretinal implantation," Biomaterials, 23:797-804, 2002. 2009/02 143 92 Al 8/2009 Kameoka et al. Hess et al., "PECVD silicon carbide as a thin film packaging 2010/0003143 Al * 1/2010 Toonder .............. BO1F 13/0059 material for microfabricated neural electrodes," Mater. Res. Soc. 417/53 Symp. Proc., 1009-UO4-03, 2007. US 9,526,824 B2 Page 3 (56) References Cited PCT International Search Report and Written Opinion issued in International Application No. PCT/US2011/037094, dated Jan. 13, OTHER PUBLICATIONS 2012. PCT International Search Report and Written Opinion issued in Narayan et al., "Mechanical and biological properties of nanoporous International Application No. PCT/US2010/030937, dated Feb. 21, carbon membranes," Biomed. Mater., 3:034107, 2008. 2011. Nath et al., `Buprenorphine pharmacokinetics: relative bioavail- Report: Stakeholder Workshop on a National Buprenorphine Pro- ability of sub lingual tablet and liquid formulations," J. Clin. gram, Health Canada, Nov. 18, 2004. Pharmacol., 39:619-623, 1999. Samhsa, "Results from the 2003 National Survey on Drug Use and Nurdin et al., "Haemocompatibility evaluation of DLC-and SIC- Health: National Findings," Rockeville, MD, DHHS publication, coated surfaces," Eur Cells Mat., 5: 17-28, 2003. SMA 04-3964. Office Action issued in European Application No. 10765046, mailed Schmitt et al., "Passivation and corrosion of microelectrode arrays," Jul. 11, 2013. Electrochimica Acta, 44:3865-3883, 1999. Office Action issued in U.S. Appl. No. 13/111,368, mailed Apr. 21, Voskerician et al., `Biocompatibility and biofouling of MEMS drug 2015. delivery devices," Biomaterials, 24:1959-1967, 2003. Office Action issued in U.S. Appl. No. 13/111,368, mailed Oct. 17, Yakimova et al., "Surface functionalization and biomedical appli- 2014. cations base on SiC," JPhysics D, 40: 6435-6442, 2007. Office Action issued in U.S. Appl. No. 13/264,069, mailed Feb. 22, Zorman et al., "Silicon carbide as a material for biomedical 2013.
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