Introducing NuvoCool Therapeutic Veterinary Liniments

by

George E. Hoag, Ph.D. Essentalia LLC www.Essentalia.com [email protected]

August 31, 2016

1 Developed by a Horseman for Horses . Dr. George Hoag, founder of Essentalia has owned a horse farm with his wife, Meredith for more than 30 years. . He successfully competed in Combined Driving with his pair of Welsh Cross pony sisters, Faire and Lily, for many years. . Dr. Hoag has several patents and developed many consumer products, using green and sustainable chemistry, including essential oils. . His goal was to develop the best performing liniment for horses in the market using chemicals in essential oils that have been demonstrated to turn off pain sensors and associated inflammation response and to turn on analgesic sensors that relieve pain and inflammation, based on peer-reviewed academic research. . With this goal, Dr. Hoag created NuvoCool Therapeutic Veterinary Liniment Gel and NuvoCool Therapeutic Veterinary Liniment Spray resulting in two pending patents. . Unlike most liniments in the market today, NuvoCool Veterinary Liniments are all Non-Flammable 2 Why Topical Analgesics? Similar in Horses and Humans! • Topical Analgesics are applied to the location of pain • Because they are not systemic like orally or injected Non Steroidal Antiinflammatory Drugs (NSAIDs), they have minimal side effects, generally limited to skin irritation in a small number of horses at the location of application • In Humans -NSAIDs taken orally are one of the most common causes of reported serious adverse reactions to drugs - involve the gastrointestinal tract, cardiovascular system, liver, and kidneys • In Horses – NSAIDs taken orally such as flunixin meglumine (Banamine) and phenylbutazone (Bute) can lead to gastrointestinal and renal toxicity side effects. • Topical Analgesics can be self administered, most are purchased OTC and is a simplification of drug regimes. • Complementary to other modalities, such as physical therapy, massage and ultrasound.

• Many studies have shown efficacy of topical analgesic treatment. 3 Research of Pain Perception – Nociception in Mammals

• Extremely recent field of Research – last 10 years – Think of nociceptors as conduits holding many wires and the tips of the wires are different Transient Receptor Potential Sensors – some sense warm, hot, cool, cold, different chemicals that cause pain/burning, sense cutting, impacts…. • When a horse has an impact, muscle or joint injury, Transient Receptor Potential sensors are triggered and send electrical signals to the brain, the horse feels pain, and electrical signals are sent to the point of injury and inflammation occurs. • Cycle of pain and inflammation is major issue – acute to chronic pain • Tremendous research advances – giant field of academic research, drug companies are internally investing billions dollars in new pain blockers based on nociceptors – just beginning clinical trials in humans for GI and asthma therapies …. all oral doses • NuvoCool Therapeutic Veterinary Liniment products are based on this new research

4 4) TRPA1 Signal 3) Electrical Signal Triggers Inflammation Sent to Brain via Response from Brain Afferent Nerve System

5) Electrical Signal Sent From Brain to Fetlock via Efferent Nerve System

1) Pain in Trauma Fetlock due to Injury

6) Inflammation 2) TRPA1 Response Pain Sensor Causing More Activated Pain and TRPA1 Activation 5 Ingredients in NuvoCool Stop The Cycle of Pain

Decreasing the Recovery Period NuvoCool Equine Gets Your Horse and You Back to MUSCLE, Rapidly Relieves Pain What You Love! and Helps to Stop the LIGAMENT OR Pain-Inflammation JOINT PAIN Cycle

MUSCLE OR LIGAMENT INFLAMMATION FATIGUE X Reduced Pain and Inflammation By Rapidly Reducing Allows Healing that Reduces Inflammation, Muscles and Muscle and Ligament Fatigue Ligaments can Heal Faster6 All NuvoCool Products Share in the Same Innovation Based on Patent Pending Design

Medical Research Medical Research on Nociception on the Properties and Effects Pain Receptors, Inflammation, of Natural Essential Oils Antagonists and Agonists

• Multifunctional Design for Joint, Skin, Muscle, Arthritis and Bruise Pain Relief  Nociceptor pain receptor manipulation based on very recent peer reviewed published research  Ingredients have been shown to block a key pain sensor (TRPA1) the main cause of pain and inflammation in skin, subdermal tissue, muscles and joints  Ingredients have been shown to activate a key nerve ending (TRPM8) that has known analgesic and antiinflammatory properties  Omega-3 fatty acids for topical anti-inflammation and assistance in the transport

of other ingredients through the skin 7 NuvoCool Therapeutic Liniment Gel- 16 oz. Pump

 Works Like No Other Liniment Gel Using 100% Natural Essential Oils  Non-Irritating  Blocks Pain Nociceptors Responsible for Pain and Inflammation  Great for Sore Muscles and  Turns on Nociceptors that Rapidly Relieve Pain and Inflammation Impact Injuries

 Soothes Tired and Aching Muscles After a Stressful Workout  Non Flammable 8  Contains no Alcohols, Acetone, Witch Hazel, Silicone or Dyes  No FEI Banned Substances NuvoCool Therapeutic Liniment Gel- 32 oz. Spray

 Works Like No Other Liniment Using 100% Natural Essential Oils  Easy Spray on Formulation  Blocks Pain Nociceptors Responsible for Pain and Inflammation  Dilution 1:16 for Therapeutic  Turns on Nociceptors that Rapidly Relieve Pain and Inflammation Rub-Down

 Soothes Tired and Aching Muscles After a Stressful Workout  Non Flammable 9  Contains no Alcohols, Acetone, Witch Hazel, Silicone or Dyes  No FEI Banned Substances Existing Liniment Products for Horses

• Most work by evaporation of an alcohol, acetone or witch hazel which causes a very temporary cooling effect….when solvent evaporates cooling is complete

• Alcohol and acetone are known skin irritants, cause drying of skin and have toxicity issues

• Little real support that witch hazel does anything, some research that it can reduce sores on the skin and can be an astringent (skin tightening and anti-inflammation – most witch hazel also contains alcohol.

• Many liniments also contain herbal ingredients some of which do have some known benefits, but have limited pain and inflammation effects

10 Summary . Our patent pending topical NuvoCool Therapeutic Veterinary Liniment products share ingredients that have multifunction antinflammation and pain relieving mechanisms:  TRPA1 antagonists – blocks the signal of pain and associated inflammation response  TRPM8 agonists – activates pain relieving sensors and is antiinflammatory  Omega-3 Fatty Acids – antiinflammatory – helps transport chemicals through skin

. The strong antiinflammatory properties of NuvoCool helps to stop acute pain from becoming chronic by breaking the pain-inflammation cycle.

. Because NuvoCool products are designed to target specific pain causing and pain relieving sensors, we can accomplish much more with fewer and lower concentrations of ingredients than other liniments in the market.

. Effects of NuvoCool Therapeutic Veterinary Liniment are more longer lasting than products that rely on evaporative cooling allowing horses to

recover more quickly. 11