DOCSLIB.ORG

Liniment, Quart

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Liniment, Quart Liniment Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 09/03/2019 Version: 1.1 SECTION 1: Identification 1.1. Identification Product form : Mixture Product name : Liniment 1.2. Recommended use and restrictions on use Use of the substance/mixture : Topical treatment for livestock 1.3. Supplier Sanco Industries, Inc. 1819 S. Calhoun Street Fort Wayne, IN 46802 Phone: 260-426-6281 Toll Free: 888-697-2626 1.4. Emergency telephone number Emergency number : 24 Hour Contact - CHEMTREC 1-800-424-9300 SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mixture GHS-US classification Flammable liquids Category 2 H225 Highly flammable liquid and vapor Acute toxicity (oral) Category 3 H301 Toxic if swallowed Acute toxicity (dermal) Category 3 H311 Toxic in contact with skin Acute toxicity (inhalation:dust,mist) Category 4 H332 Harmful if inhaled Skin corrosion/irritation Category 2 H315 Causes skin irritation Serious eye damage/eye irritation Category 1 H318 Causes serious eye damage Specific target organ toxicity (single exposure) Category 1 H370 Causes damage to organs Full text of H statements : see section 16 2.2. GHS Label elements, including precautionary statements GHS-US labeling Hazard pictograms (GHS-US) : Signal word (GHS-US) : Danger Hazard statements (GHS-US) : H225 - Highly flammable liquid and vapor H301+H311 - Toxic if swallowed or in contact with skin H315 - Causes skin irritation H318 - Causes serious eye damage H332 - Harmful if inhaled H370 - Causes damage to organs Precautionary statements (GHS-US) : P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking P233 - Keep container tightly closed P240 - Ground/Bond container and receiving equipment P241 - Use explosion-proof electrical/ventilating/lighting equipment P242 - Use only non-sparking tools P243 - Take precautionary measures against static discharge P260 - Do not breathe vapors P264 - Wash hands thoroughly after handling P270 - Do not eat, drink or smoke when using this product P271 - Use only outdoors or in a well-ventilated area P280 - Wear protective gloves/protective clothing/eye protection/face protection P301+P310 - If swallowed: Immediately call a poison center/doctor. P303+P361+P353 - If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower P304+P340 - If inhaled: Remove person to fresh air and keep comfortable for breathing P305+P351+P338 - If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing 09/03/2019 EN (English US) Page 1 Liniment Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations P307+P311 - If exposed: Call a poison center/doctor P330 - Rinse mouth if ingested P332+P313 - If skin irritation occurs: Get medical advice/attention P362+P364 - Take off contaminated clothing and wash it before reuse P370+P378 - In case of fire: Use an appropriate extinguisher to extinguish P403+P235 - Store in a well-ventilated place. Keep cool P501 - Dispose of contents/container in accordance with local, state, and federal regulations 2.3. Other hazards which do not result in classification No additional information available 2.4. Unknown acute toxicity (GHS US) Not applicable SECTION 3: Composition/Information on ingredients 3.1. Substances Not applicable 3.2. Mixtures Name Product identifier % GHS-US classification Methyl alcohol (CAS No) 67-56-1 37.81 Flam. Liq. 2, H225 Acute Tox. 3 (Oral), H301 Acute Tox. 3 (Dermal), H311 Acute Tox. 3 (Inhalation), H331 Skin Irrit. 2, H315 Eye Dam. 1, H318 STOT SE 1, H370 Acetone (CAS No) 67-64-1 18.9 Flam. Liq. 2, H225 Eye Irrit. 2A, H319 STOT SE 3, H336 Ethyl alcohol (CAS No) 64-17-5 1.4 Flam. Liq. 2, H225 Skin Irrit. 2, H315 Full text of hazard classes and H-statements : see section 16 SECTION 4: First-aid measures 4.1. Description of first aid measures First-aid measures general : Never give anything by mouth to an unconscious person. If you feel unwell, seek medical advice (show the label where possible). Call a poison center or doctor/physician. First-aid measures after inhalation : Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a poison center or doctor/physician if you feel unwell. First-aid measures after skin contact : Rinse skin with water/shower. Take off immediately all contaminated clothing. Immediately call a poison center or doctor/physician. Wash with plenty of soap and water. Wash contaminated clothing before reuse. If skin irritation occurs: Get medical advice/attention. First-aid measures after eye contact : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor/physician. First-aid measures after ingestion : Rinse mouth. Do NOT induce vomiting. Obtain emergency medical attention. Immediately call a poison center or doctor/physician. 4.2. Most important symptoms and effects (acute and delayed) Potential Adverse human health effects and : Harmful if inhaled. Toxic if swallowed. Toxic in contact with skin. symptoms Symptoms/injuries : Causes damage to organs. Symptoms/injuries after inhalation : Danger of serious damage to health by prolonged exposure through inhalation. Harmful if inhaled. Symptoms/injuries after skin contact : Repeated exposure to this material can result in absorption through skin causing significant health hazard. Toxic in contact with skin. Causes skin irritation. Symptoms/injuries after eye contact : Causes serious eye damage. Symptoms/injuries after ingestion : Toxic if swallowed. Swallowing a small quantity of this material will result in serious health hazard. 4.3. Immediate medical attention and special treatment, if necessary No additional information available SECTION 5: Fire-fighting measures 5.1. Suitable (and unsuitable) extinguishing media Suitable extinguishing media : Foam. Dry powder. Carbon dioxide. Water spray. Sand. Unsuitable extinguishing media : Do not use a heavy water stream. 09/03/2019 EN (English US) 2/9 Liniment Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations 5.2. Specific hazards arising from the chemical Fire hazard : Highly flammable liquid and vapor. Explosion hazard : May form flammable/explosive vapor-air mixture. 5.3. Special protective equipment and precautions for fire-fighters Firefighting instructions : Use water spray or fog for cooling exposed containers. Exercise caution when fighting any chemical fire. Prevent fire-fighting water from entering environment. Protection during firefighting : Do not enter fire area without proper protective equipment, including respiratory protection. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures General measures : Remove ignition sources. Use special care to avoid static electric charges. No smoking. 6.1.1. For non-emergency personnel Emergency procedures : Evacuate unnecessary personnel. 6.1.2. For emergency responders Protective equipment : Equip cleanup crew with proper protection. Avoid breathing dust/fume/gas/mist/vapors/spray. Emergency procedures : Ventilate area. 6.2. Environmental precautions Prevent entry to sewers and public waters. Notify authorities if liquid enters sewers or public waters. 6.3. Methods and material for containment and cleaning up Methods for cleaning up : Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible. Collect spillage. Store away from other materials. 6.4. Reference to other sections See Heading 8. Exposure controls and personal protection. SECTION 7: Handling and storage 7.1. Precautions for safe handling Additional hazards when processed : Handle empty containers with care because residual vapors are flammable. Precautions for safe handling : Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work. Provide good ventilation in process area to prevent formation of vapor. No smoking. Use only non-sparking tools. Use only outdoors or in a well-ventilated area. Avoid breathing vapors. Hygiene measures : Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. 7.2. Conditions for safe storage, including any incompatibilities Technical measures : Proper grounding procedures to avoid static electricity should be followed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting equipment. Storage conditions : Keep only in the original container in a cool, well ventilated place. Keep in fireproof place. Keep container tightly closed. Incompatible products : Strong bases. Strong acids. Incompatible materials : Sources of ignition. Direct sunlight. Heat sources. SECTION 8: Exposure controls/personal protection 8.1. Control parameters Acetone (67-64-1) ACGIH ACGIH TWA (ppm) 500 ppm ACGIH ACGIH STEL (ppm) 750 ppm OSHA OSHA PEL (TWA) (mg/m³) 2400 mg/m³ OSHA OSHA PEL (TWA) (ppm) 1000 ppm IDLH US IDLH (ppm) 2500 ppm (10% LEL) NIOSH NIOSH REL (TWA) (mg/m³) 590 mg/m³ NIOSH NIOSH REL (TWA) (ppm) 250 ppm 09/03/2019 EN (English US) 3/9 Liniment Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Ethyl alcohol (64-17-5) ACGIH ACGIH STEL (ppm) 1000 ppm OSHA OSHA PEL (TWA) (mg/m³) 1900 mg/m³ OSHA OSHA PEL (TWA) (ppm) 1000 ppm IDLH US IDLH (ppm) 3300 ppm (10% LEL) NIOSH NIOSH REL (TWA) (mg/m³) 1900 mg/m³ NIOSH NIOSH REL (TWA) (ppm) 1000 ppm Methyl alcohol (67-56-1) ACGIH ACGIH TWA (ppm) 200 ppm ACGIH ACGIH STEL (ppm) 250 ppm OSHA OSHA PEL (TWA) (mg/m³) 260 mg/m³ OSHA OSHA PEL (TWA) (ppm) 200 ppm IDLH US IDLH (ppm) 6000 ppm NIOSH NIOSH REL (TWA) (mg/m³) 260 mg/m³ NIOSH NIOSH REL (TWA) (ppm) 200 ppm NIOSH NIOSH REL (STEL) (mg/m³) 325 mg/m³ NIOSH NIOSH REL (STEL) (ppm) 250 ppm NIOSH US-NIOSH chemical category Potential for dermal absorption 8.2.
Load more

Recommended publications
  • Camphor Revisited: Focus on Toxicity
    Camphor Revisited: Focus on Toxicity Committee on Drugs This commentary updates a previous AAP state- TABLE. List of Camphor-Containing Products ment developed by the Committee on Drugs con- Product % of Camphor cerning camphor.1 The original commentary re- Absorbine Arthritic Pain Lotion 10 flected the level of concern among pediatric Act-On Rub Lotion 1.5 practitioners and poison centers about the toxicity of Anabaim Lotion 3 camphor. Since the original statement, the Food and Aveeno Anti-Itch Conc. Lotion 0.3 t Drug Administration (FDA) has recognized camphor Avalgesic Banaig Muscle Pain Reliever 2 as a safe and effective topical antitussive, analgesic, Bangesic t anesthetic, and antipruritic agent.2 Following the ap- Ben Gay Children’s Vaporizing Rub 5 proval process in 1983, the FDA required that the Betuline Lotion t concentration of camphor in products not exceed Campho-phemque First Aid Gel 10.8 Campho-phenique Uquid 10.85 11%.2 Fligher concentrations were not more effective Campho-phemque Powder 4.375 and could cause more serious adverse reactions if Counterpain Rub t accidentally ingested. Most reported camphor-re- Deep Down Rub 0.5 lated fatalities involved agents containing a concen- Dencorub Cream Dermal Rub t tration greater than 11%. Dermolin Liniment t Ingestion of potentially toxic substances by chil- Emul-O-Balm 1.1 dren is related to the availabffity of a product in their Heet Lotion 3 3.6 environment. Camphor remains widely available Heat Spray Minit-Rub 3.5 (Table). The toxicity of camphor when inappropri- Mollifene Ear Drops t ately used is well documented.6 Ingestion is the Musterole Regular 4 most common route of potentially toxic exposure, Panalgesic 3 with rapid onset of toxic effects.
    [Show full text]
  • Absorbine Veterinary Liniment for Horses
    Doc# 03.287 Ver. 11 SAFETY DATA SHEET ABSORBINE® VETERINARY LINIMENT SECTION 1 - PRODUCT AND COMPANY IDENTIFICATION 1.1 Trade Name (as labeled): Absorbine® Veterinary Liniment Synonyms: N/A CAS No: Mixture 1.2 Product Use: Soothes sore muscles and stiff joints 1.3 Company Name: W.F. Young Company Address: 302 Benton Dr Company Address Cont: East Longmeadow, MA 01028 Business Phone: ( 413) 526-9999 Website: www.wfyoung.com 1.4 Emergency Telephone Number: (413) 526-9999 Date of Current Revision: January 17, 2017 Date of Last Revision: August 7, 2015 SECTION 2 - HAZARD IDENTIFICATION EMERGENCY OVERVIEW: This product is a green thin liquid with an acetone odor. Health Hazards: May cause skin, eye, and respiratory system irritation. Flammabilit Hazards: This product is a flammable liquid with a flash point over 20°F (-6. 7°C). Reactivit Hazards: None. Environmental Hazards: The environmental effectsof this product have not been investigated, however release may cause long term adverse environmental effects. US DOT Symbols: EU and GHS Symbols: Signal Word: Danger! 2.1 CLASSIFICATION OF SUBSTANCE OR MIXTURE IN ACCORDANCE WITH 29 CFR 1200 (OSHA HCSl AND THE EUROPEAN UNION DIRECTIVES: This product does meet the definition of a hazardous substance or preparation as defined by 29 CFR 1910. 1200 or the European Union Council Directives 67 /548/EEC, 1999/45/EC, 1272/2008/EC and subsequent Directives. EU HAZARD CLASSIFICATIONOF INGREDIENTS PER DIRECTIVE 1272/2008/EC: IndexNumber: EC# 201-939-0 This substance is not classified in the AnnexVI of Directive 67/548/EEC EC# 200-662-2 This substance is classified in the AnnexVI of Directive 67/548/EEC Index# 606-001-00-8 Substances not listed either individually or in group entries must be self classified.
    [Show full text]
  • Inhalation Solution, USP for Oral Inhalation Use What Is Tobramycin
    PATIENT INFORMATION TOBRAMYCIN (TOE-BRA-MYE-SIN) Inhalation Solution, USP for oral inhalation use What is Tobramycin Inhalation Solution? Tobramycin inhalation solution is a prescription medicine that is used to treat people with cystic fibrosis who have a bacterial infection called Pseudomonas aeruginosa. Tobramycin inhalation solution contains an antibacterial medicine called tobramycin (an aminoglycoside). It is not known if tobramycin inhalation solution is safe and effective: in children under 6 years of age in people who have an FEV1 less than 25% or greater than 75% predicted in people who are colonized with a bacterium called Burkholderia cepacia Do not take tobramycin inhalation solution if you are allergic to tobramycin, any of the ingredients in tobramycin inhalation solution, or to any other aminoglycoside antibacterial. See the end of this Patient Information for a complete list of ingredients in tobramycin inhalation solution. Before you take tobramycin inhalation solution, tell your healthcare provider about all of your medical conditions, including if you: have or have had hearing problems (including noises in your ears such as ringing or hissing) have dizziness have or have had kidney problems have or have had problems with muscle weakness such as myasthenia gravis or Parkinson’s disease have or have had breathing problems such as wheezing, coughing, or chest tightness are pregnant or plan to become pregnant. Tobramycin inhalation solution is in a class of drugs that can harm your unborn baby. are breastfeeding or plan to breastfeed. It is not known if tobramycin passes into your breast milk. are receiving aminoglycoside therapy by injection or through a vein (intravenous) while taking tobramycin inhalation solution.
    [Show full text]
  • Hydrogen Peroxide, and This Is the Same Substance That Can Be Purchased in a 32-Ounce Plastic Bottle at Walmart, for 88 Cents, Or at Walgreens for Under a $1.00
    An At-Home Treatment That Can Cure Any Virus, Including Coronavirus Originally Conceptualized, circa 1990, by Charles Farr, MD Subsequently Researched and Prescribed by Frank Shallenberger, MD Current Protocol Created by Thomas Levy, MD, JD Although COVID-19, aka coronavirus, is deadly in some select cases, and it can spread rapidly, there is a simple, very inexpensive, and highly effective treatment that can treat and rapidly resolve coronavirus and virtually any other respiratory virus. While different individuals can be expected to have variable degrees of positive response, this intervention can be anticipated to eliminate eventual fatal disease outcomes in all but the most advanced cases. As I hope you will eventually experience, the treatment works for all acute viral infections, and especially well for flu viruses of any variety. In fact, although we are constantly conditioned to not believe in anything “too good to be true,” you will never have to worry about getting a cold or the flu again because you can cure it on your own. The key ingredient in this treatment is common household 3% hydrogen peroxide, and this is the same substance that can be purchased in a 32-ounce plastic bottle at Walmart, for 88 cents, or at Walgreens for under a $1.00. Perhaps you have never heard of hydrogen peroxide therapy, but since the treatment was first championed by Dr. Charles Farr in about 1990, thousands of doctors have used this therapy for decades to conquer infections in many thousands of patients throughout the world. How and Why Hydrogen Peroxide Works Because hydrogen peroxide consists of a water molecule (H2O) with an extra oxygen atom (H2O2), it is this extra oxygen atom that makes it so deadly for viruses.
    [Show full text]
  • Inhalation Anesthesia Machine / Vaporizer / Waste Gas Maintenance
    Office of Research Office of Responsible Research Practices Institutional Animal Care and Use Committee INHALATION ANESTHESIA MACHINE / VAPORIZER / WASTE GAS MAINTENANCE Overview/Purpose To reduce risk of anesthetic gas exposure to animals and personnel, proper maintenance of anesthesia equipment, appropriate waste scavenging systems, and safe administration techniques must be employed. Preventative maintenance is key in reaching this goal. ULAR machines are maintained by ULAR while maintenance of lab owned machines is required by the research team. Personnel must be properly trained to provide safe anesthesia to animals and in the proper use and maintenance of anesthetic machines. Training is available through ULAR http://ular.osu.edu/training/animal-handling-and-technique-training/. Definition 1. Anesthesia Machine. - The entire piece of equipment that is used to deliver precise amounts of inhaled anesthetic gas and/or a carrier gas (usually air, O2 or CO2, alone or in a mix). It consists of multiple parts (precision vaporizer, carrier gas regulators, flow meters, delivery/breathing circuits and scavenge systems and possibly a rebreathing reservoir (bag). a. Rebreathing systems – for animals weighing over ~5kg b. Non-rebreathing systems – for rodents and animals weighing under ~5kg. 2. Breathing Circuit: The tubing that delivers the fresh gas/anesthetic gas mixture from the machine to the patient. a. Rebreathing circuits direct the expired gases through a soda lime canister for absorption of carbon dioxide, which are then “rebreathed” by the patient. b. Non-rebreathing circuits are designed to deliver oxygen and anesthetic gases with less resistance to breathing in small patients and have a higher fresh gas flow to remove carbon dioxide.
    [Show full text]
  • Veterinary Dairy Spray Liniment by Dan Leiterman
    1-888-376-6777 www.crystalcreeknatural.com December 2011 Introducing - Veterinary Dairy Spray Liniment By Dan Leiterman Crystal Creek is pleased to announce the addition of the new Veterinary Dairy Spray Liniment Features: Veterinary Dairy Spray Liniment • Available In A 24 oz. Spray Bottle Or A One Gallon (128 oz.) Refill Jug (VDSL) to our family of liniments (Veterinary Dairy Liniment and • A High Performance – Strong Relief Formula: Lini-Rub). Veterinary Dairy Spray Liniment provides the same ‘Contrast Therapy’ Warming and Cooling excellent performance as the original Analgesic Pain Relief rub-on Veterinary Dairy Liniment, only now with the convenience of a Anti-Inflammatory spray-on application. Anti-Microbial Skin Support – an aloe vera based formula Veterinary Dairy Spray Liniment is a powerful analgesic that combines • New Color For Lingering Identification Of Sprayed Animals the proven benefits of both warming and cooling ‘contrast therapy’ for • Meets National Organic Program Standards – challenged muscle tissue and edema Consider For Organic Use relief. The deep penetrating warmth soothes and supports proper • Economical To Use: circulation, while the lingering Retail Price coolness helps to reduce edema and inflammation of muscle tissue. 24 oz. Spray Bottle $29.95 / bottle If you prefer a spray-on liniment, Case Price (6 bottles/case) try Veterinary Dairy Spray Liniment and see the difference – it is stronger $28.95 / bottle and is better priced than the One Gallon Jug competition. If you prefer rub-on $134.00 / gallon liniments, try the Veterinary Dairy Case Price (4 gallons/case) Liniment (a white cream based $128.00 / gallon liniment) or the Crystal Creek Lini- Rub (an oil based liniment) and experience their excellent performance.
    [Show full text]
  • Pharmacology – Inhalant Anesthetics
    Pharmacology- Inhalant Anesthetics Lyon Lee DVM PhD DACVA Introduction • Maintenance of general anesthesia is primarily carried out using inhalation anesthetics, although intravenous anesthetics may be used for short procedures. • Inhalation anesthetics provide quicker changes of anesthetic depth than injectable anesthetics, and reversal of central nervous depression is more readily achieved, explaining for its popularity in prolonged anesthesia (less risk of overdosing, less accumulation and quicker recovery) (see table 1) Table 1. Comparison of inhalant and injectable anesthetics Inhalant Technique Injectable Technique Expensive Equipment Cheap (needles, syringes) Patent Airway and high O2 Not necessarily Better control of anesthetic depth Once given, suffer the consequences Ease of elimination (ventilation) Only through metabolism & Excretion Pollution No • Commonly administered inhalant anesthetics include volatile liquids such as isoflurane, halothane, sevoflurane and desflurane, and inorganic gas, nitrous oxide (N2O). Except N2O, these volatile anesthetics are chemically ‘halogenated hydrocarbons’ and all are closely related. • Physical characteristics of volatile anesthetics govern their clinical effects and practicality associated with their use. Table 2. Physical characteristics of some volatile anesthetic agents. (MAC is for man) Name partition coefficient. boiling point MAC % blood /gas oil/gas (deg=C) Nitrous oxide 0.47 1.4 -89 105 Cyclopropane 0.55 11.5 -34 9.2 Halothane 2.4 220 50.2 0.75 Methoxyflurane 11.0 950 104.7 0.2 Enflurane 1.9 98 56.5 1.68 Isoflurane 1.4 97 48.5 1.15 Sevoflurane 0.6 53 58.5 2.5 Desflurane 0.42 18.7 25 5.72 Diethyl ether 12 65 34.6 1.92 Chloroform 8 400 61.2 0.77 Trichloroethylene 9 714 86.7 0.23 • The volatile anesthetics are administered as vapors after their evaporization in devices known as vaporizers.
    [Show full text]
  • Nebulizers and Inhalation Drugs
    JURISDICTIONS B & C DOCUMENTATION CHECKLIST NEBULIZERS AND INHALATION DRUGS Small Volume Nebulizers (A7003, A7004, A7005) & Related Compressor (E0570) REQUIRED DOCUMENTATION Standard Written Order (original, faxed, or copied) that contains: Beneficiary’s name or Medicare Beneficiary Identifier (MBI) Order date General description of the item The description can be either a general description (e.g., wheelchair or hospital bed), a HCPCS code, a HCPCS code narrative, or a brand name/model number For equipment - In addition to the description of the base item, the SWO may include all concurrently ordered options, accessories or additional features that are separately billed or require an upgraded code (List each separately). For supplies – In addition to the description of the base item, the DMEPOS order/ prescription may include all concurrently ordered supplies that are separately billed (List each separately) Quantity to be dispensed, if applicable Treating Practitioner Name or NPI Treating Practitioner’s signature Any changes or corrections have been initialed/signed and dated by the ordering practitioner Treating practioner’s signature on the written order meets CMS Signature Requirements https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/ MLNMattersArticles/downloads/MM6698.pdf For drugs used as a supply for a DME item, the written order may include: The type of solution to be dispensed is described by either: The name of the drug and the concentration of the drug in the dispensed solution (Example: Cromolyn 20
    [Show full text]
  • TOXICOLOGY and EXPOSURE GUIDELINES ______(For Assistance, Please Contact EHS at (402) 472-4925, Or Visit Our Web Site At
    (Revised 1/03) TOXICOLOGY AND EXPOSURE GUIDELINES ______________________________________________________________________ (For assistance, please contact EHS at (402) 472-4925, or visit our web site at http://ehs.unl.edu/) "All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." This early observation concerning the toxicity of chemicals was made by Paracelsus (1493- 1541). The classic connotation of toxicology was "the science of poisons." Since that time, the science has expanded to encompass several disciplines. Toxicology is the study of the interaction between chemical agents and biological systems. While the subject of toxicology is quite complex, it is necessary to understand the basic concepts in order to make logical decisions concerning the protection of personnel from toxic injuries. Toxicity can be defined as the relative ability of a substance to cause adverse effects in living organisms. This "relative ability is dependent upon several conditions. As Paracelsus suggests, the quantity or the dose of the substance determines whether the effects of the chemical are toxic, nontoxic or beneficial. In addition to dose, other factors may also influence the toxicity of the compound such as the route of entry, duration and frequency of exposure, variations between different species (interspecies) and variations among members of the same species (intraspecies). To apply these principles to hazardous materials response, the routes by which chemicals enter the human body will be considered first. Knowledge of these routes will support the selection of personal protective equipment and the development of safety plans. The second section deals with dose-response relationships.
    [Show full text]
  • Safety Data Sheet
    First issue: September 17, 2009 Revision date: October 27, 2014 SDS No. 007.636 Version: 5 SAFETY DATA SHEET In accordance with OSHA’s Hazard Communication Standard 29 CFR §1910.1200 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identifier: Absorbine® Veterinary Liniment Gel 1.2. Relevant identified uses of the substance or mixture and uses advised against Topical Analgesic 1.3. Details of the supplier of the safety data sheet Manufacturer/Supplier: W. F. Young, Inc. 302 Benton Drive East Longmeadow, MA 01028 Telephone number for information: 413 526 9999 E-mail: [email protected] 1.4. Emergency telephone number 413 526 9999 SECTION 2: HAZARDS IDENTIFICATION 2.1. Classification of the mixture F, Xn, Xi R10, 22, 43 2.2. Label elements Flammable Keep out of the reach of children Harmful if swallowed May product an allergic reaction 2.3. Other hazards Inhalation of vapors can cause anesthetic effect. Page 1 of 8 First issue: September 17, 2009 Revision date: October 27, 2014 SDS No. 007.636 Version: 5 SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS 3.2. Mixtures Hazardous ingredients information Component CAS Nr. EINECS / Amount DSD DSD ELINCS (%) Hazard R-Phrases Symbol Ethanola,denatured 64-17-5 200-578-6 40 - 70 F R11 Menthol 89-78-1 201-939-0 4 Choroxylenol 88-04-0 201-793-8 0.5 Xi R43 Spearmint Oil 8008-79-5 Not classified 0.5-1.0 Xi R43 Propylene Glycola 57-55-6 200-338-0 1 - 5 Other Components: Remaining components of this alcoholic mixture are proprietary, non-hazardous and/or are present at concentrations below reportable limits.
    [Show full text]
  • Biopharmaceutical Properties of Patches Relevant for Transdermal Drug Absorption – Confounding Factors and In‐Vitro Testing
    Biopharmaceutical Properties of Patches 16.06.2015 Relevant for Transdermal Drug Absorption Biopharmaceutical Properties of Patches Relevant for Transdermal Drug Absorption – Confounding Factors and In‐Vitro Testing Johannes Bartholomäus Pharmakreativ Consulting, Aachen Skin as Barrier to Transdermal Absorption And that’s from what Mother Nature did not design all the difficulties in transdermal drug skin as an absorption site. delivery arise. It‘s much more the opposite! Stratum corneum as lipophilic barrier June 16, 2015 J. Bartholomäus: Biopharmaceutical Properties of Patches 2 © Johannes Bartholomäus 1 Biopharmaceutical Properties of Patches 16.06.2015 Relevant for Transdermal Drug Absorption Definition TDDS by Guidelines . Transdermal drug delivery systems . Transdermal patch:** Flexible single‐ (TDDS):* A TDDS or transdermal dose preparation intended to be patch is a flexible pharmaceutical applied to the unbroken skin to preparation of varying size containing obtain a systemic delivery over an one or more active substance(s) to be extended period of time. applied on the intact skin for systemic . Transdermal patches consist of a availability. backing sheet supporting a reservoir . There are two main types of or a matrix containing the active transdermal patch systems substance(s) and on the top a depending on how the drug pressure‐sensitive adhesive, which substance is dispersed in other patch assures the adhesion of the components: preparation to the skin. – Matrix systems with drug release based on . The backing sheet is impermeable to the diffusion of drug substance. the active substance(s) and normally – Reservoir systems containing a specific liquid drug compartment and release is impermeable to water. controlled by a membrane.
    [Show full text]
  • Pulmonary Delivery of Biological Drugs
    pharmaceutics Review Pulmonary Delivery of Biological Drugs Wanling Liang 1,*, Harry W. Pan 1 , Driton Vllasaliu 2 and Jenny K. W. Lam 1 1 Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China; [email protected] (H.W.P.); [email protected] (J.K.W.L.) 2 School of Cancer and Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, UK; [email protected] * Correspondence: [email protected]; Tel.: +852-3917-9024 Received: 15 September 2020; Accepted: 20 October 2020; Published: 26 October 2020 Abstract: In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. This is because of their high potency, high specificity and desirable safety profile. The majority of biological drugs are peptide- and protein-based therapeutics with poor oral bioavailability. They are normally administered by parenteral injection (with a very few exceptions). Pulmonary delivery is an attractive non-invasive alternative route of administration for local and systemic delivery of biologics with immense potential to treat various diseases, including diabetes, cystic fibrosis, respiratory viral infection and asthma, etc. The massive surface area and extensive vascularisation in the lungs enable rapid absorption and fast onset of action. Despite the benefits of pulmonary delivery, development of inhalable biological drug is a challenging task. There are various anatomical, physiological and immunological barriers that affect the therapeutic efficacy of inhaled formulations. This review assesses the characteristics of biological drugs and the barriers to pulmonary drug delivery.
    [Show full text]