The Importance of Inhalation Volume When Measuring Smoking Behavior
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The Honorable Jarrett Keohokalole, Vice Chair; and Members of the Senate Committee on Judiciary
DAVID Y. IGE ISAAC W. CHOY GOVERNOR DIRECTOR OF TAXATION JOSH GREEN M.D. LT. GOVERNOR STATE OF HAWAII DEPARTMENT OF TAXATION P.O. BOX 259 HONOLULU, HAWAII 96809 PHONE NO: (808) 587-1540 FAX NO: (808) 587-1560 To: The Honorable Karl Rhoads, Chair; The Honorable Jarrett Keohokalole, Vice Chair; and Members of the Senate Committee on Judiciary The Honorable Donovan M. Dela Cruz, Chair; The Honorable Gilbert S.C. Keith-Agaran, Vice Chair; and Members of the Senate Committee on Ways and Means From: Isaac W. Choy, Director Department of Taxation Date: March 3, 2021 Time: 9:45 A.M. Place: Via Videoconference, Hawaii State Capitol Re: S.B. 1147, S.D. 1, Relating to Tobacco Products The Department of Taxation (Department) supports S.B. 1147, S.D. 1, an Administration measure, and offers the following comments for your consideration. S.B. 1147, S.D. 1, makes multiple amendments to chapter 245, Hawaii Revised Statutes (HRS). These amendments will enable improved regulation of the sale of electronic smoking products. S.D. 1 has a defective effective date of January 1, 2050. The Department appreciates the increased wholesaler/dealer license fees and retail permit fees in sections 245-2 and 245-2.5, HRS, respectively. In most cases, the current fee amount does not cover the cost to the State to issue the license or permit. The Department prefers this measure over the other measures proposing to impose the tobacco tax on electronic smoking products because the new imposition can be administered as part of the existing tax. The Department is able to administer this bill as currently written, provided a functional effective date of January 1, 2022 or later is inserted. -
Absorbine Veterinary Liniment for Horses
Doc# 03.287 Ver. 11 SAFETY DATA SHEET ABSORBINE® VETERINARY LINIMENT SECTION 1 - PRODUCT AND COMPANY IDENTIFICATION 1.1 Trade Name (as labeled): Absorbine® Veterinary Liniment Synonyms: N/A CAS No: Mixture 1.2 Product Use: Soothes sore muscles and stiff joints 1.3 Company Name: W.F. Young Company Address: 302 Benton Dr Company Address Cont: East Longmeadow, MA 01028 Business Phone: ( 413) 526-9999 Website: www.wfyoung.com 1.4 Emergency Telephone Number: (413) 526-9999 Date of Current Revision: January 17, 2017 Date of Last Revision: August 7, 2015 SECTION 2 - HAZARD IDENTIFICATION EMERGENCY OVERVIEW: This product is a green thin liquid with an acetone odor. Health Hazards: May cause skin, eye, and respiratory system irritation. Flammabilit Hazards: This product is a flammable liquid with a flash point over 20°F (-6. 7°C). Reactivit Hazards: None. Environmental Hazards: The environmental effectsof this product have not been investigated, however release may cause long term adverse environmental effects. US DOT Symbols: EU and GHS Symbols: Signal Word: Danger! 2.1 CLASSIFICATION OF SUBSTANCE OR MIXTURE IN ACCORDANCE WITH 29 CFR 1200 (OSHA HCSl AND THE EUROPEAN UNION DIRECTIVES: This product does meet the definition of a hazardous substance or preparation as defined by 29 CFR 1910. 1200 or the European Union Council Directives 67 /548/EEC, 1999/45/EC, 1272/2008/EC and subsequent Directives. EU HAZARD CLASSIFICATIONOF INGREDIENTS PER DIRECTIVE 1272/2008/EC: IndexNumber: EC# 201-939-0 This substance is not classified in the AnnexVI of Directive 67/548/EEC EC# 200-662-2 This substance is classified in the AnnexVI of Directive 67/548/EEC Index# 606-001-00-8 Substances not listed either individually or in group entries must be self classified. -
Inhalation Solution, USP for Oral Inhalation Use What Is Tobramycin
PATIENT INFORMATION TOBRAMYCIN (TOE-BRA-MYE-SIN) Inhalation Solution, USP for oral inhalation use What is Tobramycin Inhalation Solution? Tobramycin inhalation solution is a prescription medicine that is used to treat people with cystic fibrosis who have a bacterial infection called Pseudomonas aeruginosa. Tobramycin inhalation solution contains an antibacterial medicine called tobramycin (an aminoglycoside). It is not known if tobramycin inhalation solution is safe and effective: in children under 6 years of age in people who have an FEV1 less than 25% or greater than 75% predicted in people who are colonized with a bacterium called Burkholderia cepacia Do not take tobramycin inhalation solution if you are allergic to tobramycin, any of the ingredients in tobramycin inhalation solution, or to any other aminoglycoside antibacterial. See the end of this Patient Information for a complete list of ingredients in tobramycin inhalation solution. Before you take tobramycin inhalation solution, tell your healthcare provider about all of your medical conditions, including if you: have or have had hearing problems (including noises in your ears such as ringing or hissing) have dizziness have or have had kidney problems have or have had problems with muscle weakness such as myasthenia gravis or Parkinson’s disease have or have had breathing problems such as wheezing, coughing, or chest tightness are pregnant or plan to become pregnant. Tobramycin inhalation solution is in a class of drugs that can harm your unborn baby. are breastfeeding or plan to breastfeed. It is not known if tobramycin passes into your breast milk. are receiving aminoglycoside therapy by injection or through a vein (intravenous) while taking tobramycin inhalation solution. -
Hydrogen Peroxide, and This Is the Same Substance That Can Be Purchased in a 32-Ounce Plastic Bottle at Walmart, for 88 Cents, Or at Walgreens for Under a $1.00
An At-Home Treatment That Can Cure Any Virus, Including Coronavirus Originally Conceptualized, circa 1990, by Charles Farr, MD Subsequently Researched and Prescribed by Frank Shallenberger, MD Current Protocol Created by Thomas Levy, MD, JD Although COVID-19, aka coronavirus, is deadly in some select cases, and it can spread rapidly, there is a simple, very inexpensive, and highly effective treatment that can treat and rapidly resolve coronavirus and virtually any other respiratory virus. While different individuals can be expected to have variable degrees of positive response, this intervention can be anticipated to eliminate eventual fatal disease outcomes in all but the most advanced cases. As I hope you will eventually experience, the treatment works for all acute viral infections, and especially well for flu viruses of any variety. In fact, although we are constantly conditioned to not believe in anything “too good to be true,” you will never have to worry about getting a cold or the flu again because you can cure it on your own. The key ingredient in this treatment is common household 3% hydrogen peroxide, and this is the same substance that can be purchased in a 32-ounce plastic bottle at Walmart, for 88 cents, or at Walgreens for under a $1.00. Perhaps you have never heard of hydrogen peroxide therapy, but since the treatment was first championed by Dr. Charles Farr in about 1990, thousands of doctors have used this therapy for decades to conquer infections in many thousands of patients throughout the world. How and Why Hydrogen Peroxide Works Because hydrogen peroxide consists of a water molecule (H2O) with an extra oxygen atom (H2O2), it is this extra oxygen atom that makes it so deadly for viruses. -
Inhalation Anesthesia Machine / Vaporizer / Waste Gas Maintenance
Office of Research Office of Responsible Research Practices Institutional Animal Care and Use Committee INHALATION ANESTHESIA MACHINE / VAPORIZER / WASTE GAS MAINTENANCE Overview/Purpose To reduce risk of anesthetic gas exposure to animals and personnel, proper maintenance of anesthesia equipment, appropriate waste scavenging systems, and safe administration techniques must be employed. Preventative maintenance is key in reaching this goal. ULAR machines are maintained by ULAR while maintenance of lab owned machines is required by the research team. Personnel must be properly trained to provide safe anesthesia to animals and in the proper use and maintenance of anesthetic machines. Training is available through ULAR http://ular.osu.edu/training/animal-handling-and-technique-training/. Definition 1. Anesthesia Machine. - The entire piece of equipment that is used to deliver precise amounts of inhaled anesthetic gas and/or a carrier gas (usually air, O2 or CO2, alone or in a mix). It consists of multiple parts (precision vaporizer, carrier gas regulators, flow meters, delivery/breathing circuits and scavenge systems and possibly a rebreathing reservoir (bag). a. Rebreathing systems – for animals weighing over ~5kg b. Non-rebreathing systems – for rodents and animals weighing under ~5kg. 2. Breathing Circuit: The tubing that delivers the fresh gas/anesthetic gas mixture from the machine to the patient. a. Rebreathing circuits direct the expired gases through a soda lime canister for absorption of carbon dioxide, which are then “rebreathed” by the patient. b. Non-rebreathing circuits are designed to deliver oxygen and anesthetic gases with less resistance to breathing in small patients and have a higher fresh gas flow to remove carbon dioxide. -
Pharmacology – Inhalant Anesthetics
Pharmacology- Inhalant Anesthetics Lyon Lee DVM PhD DACVA Introduction • Maintenance of general anesthesia is primarily carried out using inhalation anesthetics, although intravenous anesthetics may be used for short procedures. • Inhalation anesthetics provide quicker changes of anesthetic depth than injectable anesthetics, and reversal of central nervous depression is more readily achieved, explaining for its popularity in prolonged anesthesia (less risk of overdosing, less accumulation and quicker recovery) (see table 1) Table 1. Comparison of inhalant and injectable anesthetics Inhalant Technique Injectable Technique Expensive Equipment Cheap (needles, syringes) Patent Airway and high O2 Not necessarily Better control of anesthetic depth Once given, suffer the consequences Ease of elimination (ventilation) Only through metabolism & Excretion Pollution No • Commonly administered inhalant anesthetics include volatile liquids such as isoflurane, halothane, sevoflurane and desflurane, and inorganic gas, nitrous oxide (N2O). Except N2O, these volatile anesthetics are chemically ‘halogenated hydrocarbons’ and all are closely related. • Physical characteristics of volatile anesthetics govern their clinical effects and practicality associated with their use. Table 2. Physical characteristics of some volatile anesthetic agents. (MAC is for man) Name partition coefficient. boiling point MAC % blood /gas oil/gas (deg=C) Nitrous oxide 0.47 1.4 -89 105 Cyclopropane 0.55 11.5 -34 9.2 Halothane 2.4 220 50.2 0.75 Methoxyflurane 11.0 950 104.7 0.2 Enflurane 1.9 98 56.5 1.68 Isoflurane 1.4 97 48.5 1.15 Sevoflurane 0.6 53 58.5 2.5 Desflurane 0.42 18.7 25 5.72 Diethyl ether 12 65 34.6 1.92 Chloroform 8 400 61.2 0.77 Trichloroethylene 9 714 86.7 0.23 • The volatile anesthetics are administered as vapors after their evaporization in devices known as vaporizers. -
Nebulizers and Inhalation Drugs
JURISDICTIONS B & C DOCUMENTATION CHECKLIST NEBULIZERS AND INHALATION DRUGS Small Volume Nebulizers (A7003, A7004, A7005) & Related Compressor (E0570) REQUIRED DOCUMENTATION Standard Written Order (original, faxed, or copied) that contains: Beneficiary’s name or Medicare Beneficiary Identifier (MBI) Order date General description of the item The description can be either a general description (e.g., wheelchair or hospital bed), a HCPCS code, a HCPCS code narrative, or a brand name/model number For equipment - In addition to the description of the base item, the SWO may include all concurrently ordered options, accessories or additional features that are separately billed or require an upgraded code (List each separately). For supplies – In addition to the description of the base item, the DMEPOS order/ prescription may include all concurrently ordered supplies that are separately billed (List each separately) Quantity to be dispensed, if applicable Treating Practitioner Name or NPI Treating Practitioner’s signature Any changes or corrections have been initialed/signed and dated by the ordering practitioner Treating practioner’s signature on the written order meets CMS Signature Requirements https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/ MLNMattersArticles/downloads/MM6698.pdf For drugs used as a supply for a DME item, the written order may include: The type of solution to be dispensed is described by either: The name of the drug and the concentration of the drug in the dispensed solution (Example: Cromolyn 20 -
Dpci National Illicit Cigarettes in South Africa
SOUTH AFRICAN POLICE SERVICE SOUTH AFRICAN POLICE SERVICE DPCI NATIONAL ILLICIT CIGARETTES IN SOUTH AFRICA Priority Crime Management Centre Analytical Approach: To Focus on or/and Affect the Business System of Crime PERIOD: 1 APRIL 2017 – 31 MARCH 2018 1 BACKGROUND It will be seen that the name or reference in our view is rather a misnomer in that it does not amount to any illicit trade in tobacco but rather CRIMINAL ACTS Fraud or Tax Evasion in terms of the tax laws. The illicit cigarettes trade is defined as “the production, import, export, purchase, sale, or possession of tobacco goods which fail to comply with legislation” (FATF 2012). Illicit cigarettes trade activities fall under 3 categories: § Contrabrand: cigarettes smuggled from abroad without domestic duty paid. • Counterfeit: cigarettes manufactured without authorization of the rightful owners, with intent to deceive consumers and to avoid paying duty. • Illicit whites: brands manufactured legitimately in one country, but smuggled and sold in another without duties being paid. • Cigarette smuggling, also informally referred to as “bootlegging,” is the illicit transportation of cigarettes or cigars from an administrative division with low taxation to a division with high taxation for sale and consumption. The practice, commonly used by organized crime syndicates and rebel groups, is a form of tax evasion. • BACKGROUND Modus operandi as followed by perpetrators regarding the illicit trade in tobacco • Smuggling genuine, counterfeit and illicit branded cigarettes; • Diversion of cigarettes intended for export; • Trading in illicit tobacco; • Non-reporting of income from trade in illicit tobacco to evade income and sales taxes; • Operating legitimate businesses as using the business as a front to facilitate illicit trade (from Zimbabwe to SA). -
Tobacco Advertising in Maputo, Mozambique: How Will They Keep Pressing? (Publicidad Del Tabaco En Maputo, Mozambique: ¿Cómo Aguantarán La Presión?)
13 CARTAS 189-157 (251-252).qxd 19/5/06 10:05 Página 251 CARTAS AL DIRECTOR Tobacco advertising in Maputo, Mozambique: how will they keep pressing? (Publicidad del tabaco en Maputo, Mozambique: ¿cómo aguantarán la presión?) Dear Editor: To describe the current condition of tobacco advertising in a developing country with low prevalence of cigarette smok- ing, we decided to quantify the proportion of billboard and news- 251 Gac Sanit. 2006;20(3):251-2 13 CARTAS 189-157 (251-252).qxd 19/5/06 10:05 Página 252 Cartas al Director paper advertising devoted to tobacco and to analyze its con- Figure 1. Tobacco billboard-advertising in Maputo, tents. Mozambique (April, 2005). Maputo outdoor advertising was surveyed by 3 observers (in loco and after visualizing the images recorded in video), both in downtown largest and busier avenues (24th of July, 25th of September, Eduardo Mondlane, Guerra Popular, Julius Nyerere, Karl Marx, Kenneth Kaunda, Mao Tse Tung, Vladimir Lenine) and in the suburbs (Acordos de Lusaka, Angola, Joaquim Chissano, FPLM, Julius Nyerere, Malhangalene, Moçambique, OUA, Vladimir Lenine). The total length of the streets surveyed was approximately 120 kilometres. The main daily (Expresso, Mediafax, Notícias) and weekly (Demos, Domingo, Embondeiro, País, Savana, Zambeze) newspapers published in Maputo were checked to identify advertising items. In April 2005, we identified 707 billboards (79.9% down- town; 45.0% larger than 1 m2 as estimated by the observers and 8.4% blank). Only 2 tobacco advertisements were observed (0.3% of the non-blank billboards). Both were large panels, one with the typical image of a group of people smoking, and the other displaying a tobacco plantation (fig. -
Safety Data Sheet
First issue: September 17, 2009 Revision date: October 27, 2014 SDS No. 007.636 Version: 5 SAFETY DATA SHEET In accordance with OSHA’s Hazard Communication Standard 29 CFR §1910.1200 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identifier: Absorbine® Veterinary Liniment Gel 1.2. Relevant identified uses of the substance or mixture and uses advised against Topical Analgesic 1.3. Details of the supplier of the safety data sheet Manufacturer/Supplier: W. F. Young, Inc. 302 Benton Drive East Longmeadow, MA 01028 Telephone number for information: 413 526 9999 E-mail: [email protected] 1.4. Emergency telephone number 413 526 9999 SECTION 2: HAZARDS IDENTIFICATION 2.1. Classification of the mixture F, Xn, Xi R10, 22, 43 2.2. Label elements Flammable Keep out of the reach of children Harmful if swallowed May product an allergic reaction 2.3. Other hazards Inhalation of vapors can cause anesthetic effect. Page 1 of 8 First issue: September 17, 2009 Revision date: October 27, 2014 SDS No. 007.636 Version: 5 SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS 3.2. Mixtures Hazardous ingredients information Component CAS Nr. EINECS / Amount DSD DSD ELINCS (%) Hazard R-Phrases Symbol Ethanola,denatured 64-17-5 200-578-6 40 - 70 F R11 Menthol 89-78-1 201-939-0 4 Choroxylenol 88-04-0 201-793-8 0.5 Xi R43 Spearmint Oil 8008-79-5 Not classified 0.5-1.0 Xi R43 Propylene Glycola 57-55-6 200-338-0 1 - 5 Other Components: Remaining components of this alcoholic mixture are proprietary, non-hazardous and/or are present at concentrations below reportable limits. -
Inhalation Therapy - Approaches and Challenges
Online - 2455-3891 Vol 11, Issue 4, 2018 Print - 0974-2441 Review Article INHALATION THERAPY - APPROACHES AND CHALLENGES SAYANI BHATTACHARYYA*, BHARANI S SOGALI Department of Pharmaceutics, Krupanidhi College of Pharmacy, No: 12/1 Carmelaram Road, Chikka Bellandur, Varthur, Hobli, Carmelaram Post, Bengaluru – 560 035, Karnataka, India. Email:[email protected] Received: 05 December 2017, Revised and Accepted: 02 January 2018 ABSTRACT Inhalation therapy is an effective way for local and systemic delivery of miscellaneous drugs for pulmonary and non-pulmonary diseases. The inhalation therapy aims to target specific cells or regions of the lung, bypassing the lung’s clearance mechanisms and thereby providing high retention of the drug for longer periods. It helps in improved penetration of intravenously administered antibiotics into lung parenchymal tissue and bronchial secretions, and as a result, their potential systemic toxicity is reduced when given over prolonged periods of time. The advancement in device technology supports the development of more efficient therapy in the form of delivering finer particles into the lung in large doses. Therefore, meticulous daily management of lung disease, together with prompt, aggressive treatment of exacerbations can be achieved through inhalation to preserve lung function. This review summarizes the features of inhalation delivery devices, their advantages and limitations, challenges in formulation and brief description of novel technologies currently marketed. Keywords: Lung, Inhalation, Target, Local delivery, Systemic delivery, Novel technologies. © 2018 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4. 0/) DOI: http://dx.doi.org/10.22159/ajpcr.2018.v11i4.24117 INTRODUCTION while drug localized at the upper airways are removed by ciliated cells in the epithelial region. -
Pulmonary Delivery of Biological Drugs
pharmaceutics Review Pulmonary Delivery of Biological Drugs Wanling Liang 1,*, Harry W. Pan 1 , Driton Vllasaliu 2 and Jenny K. W. Lam 1 1 Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China; [email protected] (H.W.P.); [email protected] (J.K.W.L.) 2 School of Cancer and Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, UK; [email protected] * Correspondence: [email protected]; Tel.: +852-3917-9024 Received: 15 September 2020; Accepted: 20 October 2020; Published: 26 October 2020 Abstract: In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. This is because of their high potency, high specificity and desirable safety profile. The majority of biological drugs are peptide- and protein-based therapeutics with poor oral bioavailability. They are normally administered by parenteral injection (with a very few exceptions). Pulmonary delivery is an attractive non-invasive alternative route of administration for local and systemic delivery of biologics with immense potential to treat various diseases, including diabetes, cystic fibrosis, respiratory viral infection and asthma, etc. The massive surface area and extensive vascularisation in the lungs enable rapid absorption and fast onset of action. Despite the benefits of pulmonary delivery, development of inhalable biological drug is a challenging task. There are various anatomical, physiological and immunological barriers that affect the therapeutic efficacy of inhaled formulations. This review assesses the characteristics of biological drugs and the barriers to pulmonary drug delivery.