Sequencea Acc. No.B Protein Name Modifications # Psmsc MH+ [Da]

Home , Aldolase B, FAM71D, Selenocysteine lyase

Appendix B Table 4.2 Peptides identified from cysDML experiment. Sequencea Acc. No.b Protein Name Modifications # PSMsc MH+ [Da]d Xcorre N-Term(Dimethyl); AAAIVGCIGVIAEVDKAALVKR Q8VC12 Urocanate hydratase C7(Carbamidomethyl); K16(Dimethyl); 1 2308.384 3.26 K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); AAAIVGCIGVIAEVDKAALVKR Q8VC12 Urocanate hydratase 1 2332.516 3.56 K16(HeavyDimethyl); K21(HeavyDimethyl) Nuclear speckle splicing AAALEAHLDVTKQK Q5NCR9 K12(Dimethyl); K14(Dimethyl) 1 1550.881 2.16 regulatory protein 1

Elongation factor 1- N-Term(Dimethyl); AAAPAPEEEMDECEQALAAEPK Q9D8N0 1 2413.086 3.87 gamma C13(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Elongation factor 1- AAAPAPEEEMDECEQALAAEPK Q9D8N0 C13(Carbamidomethyl); 2 2429.173 3.15 gamma K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Elongation factor 1- M10(Oxidation); AAAPAPEEEMDECEQALAAEPK Q9D8N0 1 2445.180 2.35 gamma C13(Carbamidomethyl); K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dehydrogenase/reductas AACDRLAADCAHELRR Q99L04 C3(Carbamidomethyl); 1 1920.965 2.42 e SDR family member 1 C10(Carbamidomethyl) Group XIIB N-Term(Dimethyl); AACICAEEEKEEL Q8VC81 phospholipase A2-like C3(Carbamidomethyl); 8 1607.725 3.22 protein C5(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Group XIIB C3(Carbamidomethyl); AACICAEEEKEEL Q8VC81 phospholipase A2-like 6 1623.809 2.82 C5(Carbamidomethyl); protein K10(HeavyDimethyl) N-Term(Dimethyl); AADAHVDAHYYEQNEQPTGTCAACIT Isoform Short of P55264-2 C21(Carbamidomethyl); 22 3305.418 7.04 GGNR Adenosine kinase C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AADAHVDAHYYEQNEQPTGTCAACIT Isoform Short of P55264-2 C21(Carbamidomethyl); 15 3313.466 6.44 GGNR Adenosine kinase C24(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); AADKDTCFSTEGPNLVTR P07724 Serum albumin 30 2037.984 5.59 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AADKDTCFSTEGPNLVTR P07724 Serum albumin K4(HeavyDimethyl); 18 2054.073 5.99 C7(Carbamidomethyl) UDP-glucose 6- N-Term(Dimethyl); K5(Dimethyl); AADLKYIEACAR O70475 3 1436.753 2.59 dehydrogenase C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); UDP-glucose 6- AADLKYIEACAR O70475 K5(HeavyDimethyl); 4 1452.844 3.13 dehydrogenase C10(Carbamidomethyl) N-Term(Dimethyl); AADLVSENCETYEAHMR Q9JLI6 Selenocysteine lyase 1 2023.885 3.83 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AADLVSENCETYEAHMR Q9JLI6 Selenocysteine lyase 1 2031.927 4.14 C9(Carbamidomethyl) Carbamoyl-phosphate AADTIGYPVMIR Q8C196 synthase [ammonia], M10(Oxidation) 1 1322.675 1.88 mitochondrial Sarcosine N-Term(Dimethyl); AADWLFSADVNRPPGSTVYTCMLNQR Q99LB7 dehydrogenase, 1 2997.434 3.57 C21(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); AADWLFSADVNRPPGSTVYTCMLNQR Q99LB7 dehydrogenase, 1 3005.484 3.27 C21(Carbamidomethyl) mitochondrial Voltage-dependent AAEQIAGSFVYSIPFSTGTVNKSNVVT N-Term(Dimethyl:2H(6)13C(2)); Q9Z1L5 calcium channel subunit 1 4073.227 2.92 ASTSIQLLDER K22(HeavyDimethyl) alpha-2/delta-3 Succinate dehydrogenase N-Term(Dimethyl); AAFGLSEAGFNTACLTK Q8K2B3 [ubiquinone] 7 1813.912 5.16 C14(Carbamidomethyl); K17(Dimethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); AAFGLSEAGFNTACLTK Q8K2B3 [ubiquinone] C14(Carbamidomethyl); 3 1830.004 3.57 flavoprotein subunit, K17(HeavyDimethyl) mitochondrial N-Term(Dimethyl); K7(Dimethyl); AAFGPGKGPIMLDEVECTGTESSLASC Galectin-3-binding E9Q5X5 C17(Carbamidomethyl); 1 2996.423 4.81 R protein (Fragment) C27(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AAFGPGKGPIMLDEVECTGTESSLASC Galectin-3-binding K7(HeavyDimethyl); E9Q5X5 2 3012.506 4.38 R protein (Fragment) C17(Carbamidomethyl); C27(Carbamidomethyl) N-Term(Dimethyl); AAGCDFNNVVK P52760 Ribonuclease UK114 4 1250.615 2.56 C4(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AAGCDFNNVVK P52760 Ribonuclease UK114 C4(Carbamidomethyl); 6 1266.705 3.01 K11(HeavyDimethyl) N-Term(Dimethyl); AAGCDFNNVVKTTVLLADMNDFGTV P52760 Ribonuclease UK114 C4(Carbamidomethyl); K11(Dimethyl); 2 4524.264 4.50 NEIYKTYFQGSLPAR K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AAGCDFNNVVKTTVLLADMNDFGTV C4(Carbamidomethyl); P52760 Ribonuclease UK114 3 4548.408 3.88 NEIYKTYFQGSLPAR K11(HeavyDimethyl); K30(HeavyDimethyl) O-acetyl-ADP-ribose N-Term(Dimethyl); AAGSLLTDECR Q922B1 4 1220.590 2.67 deacetylase MACROD1 C10(Carbamidomethyl)

O-acetyl-ADP-ribose N-Term(Dimethyl:2H(6)13C(2)); AAGSLLTDECR Q922B1 1 1228.635 2.72 deacetylase MACROD1 C10(Carbamidomethyl)

Proliferation-associated AAHLCAEAALR D3YVH7 C5(Carbamidomethyl) 8 1182.606 2.37 protein 2G4 (Fragment)

Proliferation-associated N-Term(Dimethyl); AAHLCAEAALR D3YVH7 1 1210.637 2.13 protein 2G4 (Fragment) C5(Carbamidomethyl)

Proliferation-associated N-Term(Dimethyl:2H(6)13C(2)); AAHLCAEAALR D3YVH7 1 1218.680 2.19 protein 2G4 (Fragment) C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AAHMCSAGLAGVINR P52792 Glucokinase 3 1563.831 2.83 C5(Carbamidomethyl) Glycosyltransferase 54 AAHTTRSSGNFLEK Q9D4R2 domain-containing K14(Dimethyl) 1 1546.801 2.39 protein Glyoxylate N-Term(Dimethyl); AALAQAADCEVEQWNSDDPIPR Q91Z53 reductase/hydroxypyruv 10 2484.143 6.55 C9(Carbamidomethyl) ate reductase Glyoxylate N-Term(Dimethyl:2H(6)13C(2)); AALAQAADCEVEQWNSDDPIPR Q91Z53 reductase/hydroxypyruv 7 2492.191 6.28 C9(Carbamidomethyl) ate reductase Glyoxylate N-Term(Dimethyl); AALAQAADCEVEQWNSDDPIPRKDLE Q91Z53 reductase/hydroxypyruv C9(Carbamidomethyl); K23(Dimethyl); 4 4245.062 4.59 QGVVGAHGLLCR ate reductase C37(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Glyoxylate AALAQAADCEVEQWNSDDPIPRKDLE C9(Carbamidomethyl); Q91Z53 reductase/hydroxypyruv 2 4261.175 4.58 QGVVGAHGLLCR K23(HeavyDimethyl); ate reductase C37(Carbamidomethyl) AALDGGPRALATLCFQASYLVTNCLT AP-5 complex subunit C14(Carbamidomethyl); Q3TAP4 2 4122.145 2.95 RHSTVQTFLIR beta-1 C24(Carbamidomethyl) Serine N-Term(Dimethyl); AALEALGSCLNNK Q9CZN7 hydroxymethyltransferas 1 1416.742 2.36 C9(Carbamidomethyl); K13(Dimethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); AALEALGSCLNNK Q9CZN7 hydroxymethyltransferas C9(Carbamidomethyl); 1 1432.848 1.97 e K13(HeavyDimethyl) Serine N-Term(Dimethyl); AALEALGSCLNNKYSEGYPGKR Q9CZN7 hydroxymethyltransferas C9(Carbamidomethyl); K13(Dimethyl); 5 2482.273 3.32 e K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Serine C9(Carbamidomethyl); AALEALGSCLNNKYSEGYPGKR Q9CZN7 hydroxymethyltransferas 5 2506.405 3.38 K13(HeavyDimethyl); e K21(HeavyDimethyl) Early endosome antigen N-Term(Dimethyl:2H(6)13C(2)); AALEQEKESQQLMR Q8BL66 1 1748.989 2.22 1 K7(HeavyDimethyl); M13(Oxidation) Isoform 2 of Acyl- N-Term(Dimethyl); AANVLEGVCGLQPGDR Q8BGA8-2 coenzyme A synthetase 6 1683.845 3.68 C9(Carbamidomethyl) ACSM5, mitochondrial

Isoform 2 of Acyl- N-Term(Dimethyl:2H(6)13C(2)); AANVLEGVCGLQPGDR Q8BGA8-2 coenzyme A synthetase 1 1691.902 2.89 C9(Carbamidomethyl) ACSM5, mitochondrial H/ACA N-Term(Dimethyl); AAPEESEAQAEGCSEER Q9CRB2 ribonucleoprotein 2 1877.772 3.26 C13(Carbamidomethyl) complex subunit 2 H/ACA N-Term(Dimethyl:2H(6)13C(2)); AAPEESEAQAEGCSEER Q9CRB2 ribonucleoprotein 1 1885.825 3.39 C13(Carbamidomethyl) complex subunit 2 N-Term(Dimethyl); AAPLSLCALTAVDQSVLLLKPEAK Q61838 Alpha-2-macroglobulin C7(Carbamidomethyl); K20(Dimethyl); 3 2592.507 2.68 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); AAPLSLCALTAVDQSVLLLKPEAK Q61838 Alpha-2-macroglobulin 4 2616.639 3.33 K20(HeavyDimethyl); K24(HeavyDimethyl) Electron transfer N-Term(Dimethyl:2H(6)13C(2)); flavoprotein-ubiquinone AAQIGAHTLSGACLDPAAFK Q6PF96 C13(Carbamidomethyl); 1 2071.164 2.83 oxidoreductase, K20(HeavyDimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Electron transfer C13(Carbamidomethyl); AAQIGAHTLSGACLDPAAFKELFPDW flavoprotein-ubiquinone Q6PF96 K20(HeavyDimethyl); 1 3315.899 3.65 KEK oxidoreductase, K27(HeavyDimethyl); mitochondrial K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); M4(Oxidation); M5(Oxidation); AAQMMGEKQSLRPALLMLQKQLSLPQ Matrix metalloproteinase- P41245 K8(HeavyDimethyl); M17(Oxidation); 1 4175.461 2.77 TGELDSQTLK 9 K20(HeavyDimethyl); K36(HeavyDimethyl) N-Term(Dimethyl); K5(Dimethyl); AASEKSCNCLLLK Q6PHC1 Alpha-enolase C7(Carbamidomethyl); 5 1577.834 2.86 C9(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K5(HeavyDimethyl); AASEKSCNCLLLK Q6PHC1 Alpha-enolase C7(Carbamidomethyl); 6 1601.966 3.21 C9(Carbamidomethyl); K13(HeavyDimethyl) Lipoamide acyltransferase component of branched- N-Term(Dimethyl); AASLGLLQFPILNASVDENCQNITYK P53395 7 2935.535 4.76 chain alpha-keto acid C20(Carbamidomethyl); K26(Dimethyl) dehydrogenase complex, mitochondrial

Lipoamide acyltransferase N-Term(Dimethyl:2H(6)13C(2)); component of branched- AASLGLLQFPILNASVDENCQNITYK P53395 C20(Carbamidomethyl); 7 2951.638 5.15 chain alpha-keto acid K26(HeavyDimethyl) dehydrogenase complex, mitochondrial

N-Term(Dimethyl); Isoform Short of AATFFGCIGIDKFGEILK P55264-2 C7(Carbamidomethyl); K12(Dimethyl); 3 2071.129 4.15 Adenosine kinase K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of C7(Carbamidomethyl); AATFFGCIGIDKFGEILK P55264-2 1 2095.273 3.16 Adenosine kinase K12(HeavyDimethyl); K18(HeavyDimethyl) N-Term(Dimethyl); Isoform Short of AATFFGCIGIDKFGEILKR P55264-2 C7(Carbamidomethyl); K12(Dimethyl); 2 2227.239 3.91 Adenosine kinase K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of C7(Carbamidomethyl); AATFFGCIGIDKFGEILKR P55264-2 1 2251.371 2.68 Adenosine kinase K12(HeavyDimethyl); K18(HeavyDimethyl) Methylcrotonoyl-CoA N-Term(Dimethyl); AATGEEVSAEDLGGADLHCR Q3ULD5 carboxylase beta chain, 12 2085.945 6.44 C19(Carbamidomethyl) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AATGEEVSAEDLGGADLHCR Q3ULD5 carboxylase beta chain, 10 2093.988 6.49 C19(Carbamidomethyl) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl); AATGEEVSAEDLGGADLHCRK Q3ULD5 carboxylase beta chain, 1 2242.076 3.89 C19(Carbamidomethyl); K21(Dimethyl) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AATGEEVSAEDLGGADLHCRK Q3ULD5 carboxylase beta chain, C19(Carbamidomethyl); 1 2258.156 4.37 mitochondrial K21(HeavyDimethyl) Pyrroline-5-carboxylate N-Term(Dimethyl); AATMSAVEAATCR Q9DCC4 6 1366.642 3.22 reductase 3 C12(Carbamidomethyl)

Pyrroline-5-carboxylate N-Term(Dimethyl:2H(6)13C(2)); AATMSAVEAATCR Q9DCC4 1 1374.692 3.01 reductase 3 C12(Carbamidomethyl) N-Term(Dimethyl); Isoform 2 of Nuclear C9(Carbamidomethyl); AATSAMWACQHCTFMNQPGTGHCEM P60670-2 protein localization C12(Carbamidomethyl); 2 3626.495 3.36 CSLPRT protein 4 homolog C23(Carbamidomethyl); C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Nuclear C9(Carbamidomethyl); AATSAMWACQHCTFMNQPGTGHCEM P60670-2 protein localization C12(Carbamidomethyl); 2 3634.543 5.08 CSLPRT protein 4 homolog C23(Carbamidomethyl); C26(Carbamidomethyl)

AATTLGLILGAFVICWLPFFVKELVVN 5-hydroxytryptamine C15(Carbamidomethyl); K22(Dimethyl); Q02284 1 3563.929 3.09 VCEK receptor 1F C29(Carbamidomethyl); K31(Dimethyl)

Sarcosine N-Term(Dimethyl:2H(6)13C(2)); AAVARGAQVIENCAVTGIR Q99LB7 dehydrogenase, 2 1992.111 2.94 C13(Carbamidomethyl) mitochondrial 60 kDa heat shock N-Term(Dimethyl); AAVEEGIVLGGGCALLR P63038 15 1712.931 6.73 protein, mitochondrial C13(Carbamidomethyl) 60 kDa heat shock N-Term(Dimethyl:2H(6)13C(2)); AAVEEGIVLGGGCALLR P63038 16 1720.977 6.37 protein, mitochondrial C13(Carbamidomethyl) AAVLVQQWVSYADTELIPAACGATLP N-Term(Dimethyl:2H(6)13C(2)); Q9Z1Q9 Valine--tRNA ligase 2 3290.820 4.12 ALGLR C21(Carbamidomethyl) Methylmalonyl-CoA N-Term(Dimethyl); K11(Dimethyl); AAVQVLDDIEKCLAEKQQSV P16332 2 2328.251 3.17 mutase, mitochondrial C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Methylmalonyl-CoA K11(HeavyDimethyl); AAVQVLDDIEKCLAEKQQSV P16332 2 2352.385 2.94 mutase, mitochondrial C12(Carbamidomethyl); K16(HeavyDimethyl) Isoform Cytoplasmic of N-Term(Dimethyl); K8(Dimethyl); AAVVESHKLGGTCVNVGCVPK P47791-2 Glutathione reductase, C13(Carbamidomethyl); 2 2266.200 4.42 mitochondrial C18(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Cytoplasmic of K8(HeavyDimethyl); AAVVESHKLGGTCVNVGCVPK P47791-2 Glutathione reductase, C13(Carbamidomethyl); 1 2290.345 2.48 mitochondrial C18(Carbamidomethyl); K21(HeavyDimethyl) Uroporphyrinogen N-Term(Dimethyl); AAWGEETDYTPVWCMR P70697 1 1999.870 2.38 decarboxylase C14(Carbamidomethyl) Uroporphyrinogen N-Term(Dimethyl:2H(6)13C(2)); AAWGEETDYTPVWCMR P70697 1 2007.906 4.20 decarboxylase C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C19(Carbamidomethyl); AAYESLILDGLFMEILNDCSDVDEIKFQ Isoform 3 of E3 SUMO- Q8C5D8-3 K26(HeavyDimethyl); 1 4716.390 3.33 EDGSWCPMRPK protein ligase PIAS2 C34(Carbamidomethyl); M36(Oxidation); K39(HeavyDimethyl) Succinate N-Term(Dimethyl); dehydrogenase C2(Carbamidomethyl); ACALSIAESCRPGDKVPSIK Q8K2B3 [ubiquinone] 3 2243.195 2.73 C10(Carbamidomethyl); K15(Dimethyl); flavoprotein subunit, K20(Dimethyl) mitochondrial Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase C2(Carbamidomethyl); ACALSIAESCRPGDKVPSIK Q8K2B3 [ubiquinone] C10(Carbamidomethyl); 3 2267.324 2.71 flavoprotein subunit, K15(HeavyDimethyl); mitochondrial K20(HeavyDimethyl) Short-chain specific acyl- ACASTGVIMSVNNSLYLGPILKFGSAQ C2(Carbamidomethyl); K22(Dimethyl); Q07417 CoA dehydrogenase, 1 4554.352 3.28 QKQQWITPFTNGDK K29(Dimethyl); K41(Dimethyl) mitochondrial C2(Carbamidomethyl); ACDQHLNSQKRR E9PWP9 Protein 4931408C20Rik 2 1548.808 2.97 K10(HeavyDimethyl) 3-hydroxy-3- N-Term(Dimethyl); methylglutaryl- ACDSAEVKTWLETPEGFAVIK F6X166 C2(Carbamidomethyl); K8(Dimethyl); 1 2435.241 2.36 coenzyme A reductase K21(Dimethyl) (Fragment) Isoform 2 of N-Term(Dimethyl); ACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide 11 2511.213 4.96 C2(Carbamidomethyl) hydrolase 2 Isoform 2 of N-Term(Dimethyl); ACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide 7 2527.206 4.19 C2(Carbamidomethyl); M20(Oxidation) hydrolase 2 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); ACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide 16 2519.253 5.49 C2(Carbamidomethyl) hydrolase 2 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); ACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide 8 2535.248 4.30 C2(Carbamidomethyl); M20(Oxidation) hydrolase 2 Bile acid-CoA:amino ACHPYFPLQDIVVSPPLDSLTLER Q91X34 C2(Carbamidomethyl) 2 2767.415 2.76 acid N-acyltransferase Bile acid-CoA:amino N-Term(Dimethyl); ACHPYFPLQDIVVSPPLDSLTLER Q91X34 3 2795.450 3.01 acid N-acyltransferase C2(Carbamidomethyl) Bile acid-CoA:amino N-Term(Dimethyl:2H(6)13C(2)); ACHPYFPLQDIVVSPPLDSLTLER Q91X34 6 2803.490 3.21 acid N-acyltransferase C2(Carbamidomethyl) 26S protease regulatory N-Term(Dimethyl:2H(6)13C(2)); ACLIFFDEIDAIGGAR P46471 1 1803.975 2.51 subunit 7 C2(Carbamidomethyl) N-Term(Dimethyl); ACLSIPHRPQQAIR Q61456 Cyclin-A1 1 1674.898 2.27 C2(Carbamidomethyl) Arylacetamide N-Term(Dimethyl); ACPLLANDNILHHLPK Q99PG0 2 1882.033 3.27 deacetylase C2(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Arylacetamide ACPLLANDNILHHLPK Q99PG0 C2(Carbamidomethyl); 2 1898.136 3.01 deacetylase K16(HeavyDimethyl) N-Term(Dimethyl); ACQGMSAVIHTAAAIDPLGAASR E9Q007 Protein Gm4450 2 2296.158 3.99 C2(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); ACQSIYPLHDVFVR D3Z6C3 3 1732.872 3.00 S3a C2(Carbamidomethyl) N-Term(Dimethyl); ACTELGIR G5E8R3 Pyruvate carboxylase 4 947.495 2.45 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ACTELGIR G5E8R3 Pyruvate carboxylase 2 955.537 2.22 C2(Carbamidomethyl) PDZ and LIM domain N-Term(Dimethyl); ACTGSLNMTLQR Q9CRA2 1 1379.677 2.22 protein 5 C2(Carbamidomethyl) ACTMLFMVLYFFTMAGSVWWVILTIT C2(Carbamidomethyl); Q61086 Frizzled-3 1 4050.146 3.26 WFLAAVPK K34(HeavyDimethyl) N-Term(Dimethyl); ACVDTALENLSTLK P19096 Fatty acid synthase 5 1590.841 3.25 C2(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ACVDTALENLSTLK P19096 Fatty acid synthase C2(Carbamidomethyl); 2 1606.926 2.32 K14(HeavyDimethyl) Non-specific lipid- N-Term(Dimethyl); ADCTITMADSDLLALMTGK P32020 7 2083.018 6.68 transfer protein C3(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Non-specific lipid- ADCTITMADSDLLALMTGK P32020 C3(Carbamidomethyl); 12 2099.104 6.10 transfer protein K19(HeavyDimethyl) N-Term(Dimethyl); ADCTITMADSDLLALMTGKMNPQSAF Non-specific lipid- P32020 C3(Carbamidomethyl); K19(Dimethyl); 5 3346.638 4.92 FQGK transfer protein K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ADCTITMADSDLLALMTGKMNPQSAF Non-specific lipid- C3(Carbamidomethyl); P32020 4 3370.790 5.08 FQGK transfer protein K19(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl); ADCTITMADSDLLALMTGKMNPQSAF Non-specific lipid- P32020 C3(Carbamidomethyl); K19(Dimethyl); 1 3615.833 4.08 FQGKLK transfer protein K30(Dimethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); ADCTITMADSDLLALMTGKMNPQSAF Non-specific lipid- P32020 K19(HeavyDimethyl); 1 3648.027 2.96 FQGKLK transfer protein K30(HeavyDimethyl); K32(HeavyDimethyl) N-Term(Dimethyl); ADFAQACQDAGVR G5E8R3 Pyruvate carboxylase 2 1436.656 4.15 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ADFAQACQDAGVR G5E8R3 Pyruvate carboxylase 9 1444.698 3.97 C7(Carbamidomethyl) ATP-sensitive inward ADFELVVILEGMVEATAMTTQCRSSY Q8JZN3 rectifier potassium C22(Carbamidomethyl) 2 4080.004 3.13 LPGELLWGHR channel 14 N-Term(Dimethyl:2H(6)13C(2)); ADGKQEQAAVEDSGPGEINEDDPDVP Isoform 2 of A-kinase Q9WTQ5-2 K4(HeavyDimethyl); 1 4476.248 2.96 AVVPLSEYDAVEREK anchor protein 12 K41(HeavyDimethyl) N-Term(Dimethyl); ADGTVLECSESSNADVFQAAR P58710 L-gulonolactone oxidase 7 2255.026 6.61 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ADGTVLECSESSNADVFQAAR P58710 L-gulonolactone oxidase 6 2263.070 6.49 C8(Carbamidomethyl) 40S ribosomal protein ADHQPLTEASYVNLPTIALCNTDSPLR P14206 C20(Carbamidomethyl) 2 2996.482 2.92 SA 40S ribosomal protein N-Term(Dimethyl); ADHQPLTEASYVNLPTIALCNTDSPLR P14206 5 3024.516 5.25 SA C20(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); ADHQPLTEASYVNLPTIALCNTDSPLR P14206 8 3032.563 4.82 SA C20(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); ADIPVVICDTPQK Q8JZR0 6 1511.812 3.76 CoA ligase 5 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- ADIPVVICDTPQK Q8JZR0 C8(Carbamidomethyl); 1 1527.902 2.23 CoA ligase 5 K13(HeavyDimethyl) ADKGDVQQSGSHNRPGPELPMSPGGP N-Term(Dimethyl:2H(6)13C(2)); E9QA57 Protein Spata31d1b 1 4797.339 2.68 TYERLASSTNTQESQEER K3(HeavyDimethyl) Isoform 2 of Cytosol N-Term(Dimethyl); ADMGGAATICSAIVSAAK Q9CPY7-2 4 1749.889 4.38 aminopeptidase C10(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol ADMGGAATICSAIVSAAK Q9CPY7-2 C10(Carbamidomethyl); 1 1765.972 2.89 aminopeptidase K18(HeavyDimethyl) Guanine nucleotide- binding protein C15(Carbamidomethyl); ADQELMTYSHDNIICGITSVSFSK P62874 1 2752.364 2.29 G(I)/G(S)/G(T) subunit K24(HeavyDimethyl) beta-1 N-Term(Dimethyl:2H(6)13C(2)); Cysteine sulfinic acid ADSVAWNPHKLLAAGLQCSALLLR Q9DBE0 K10(HeavyDimethyl); 1 2676.553 2.66 decarboxylase C18(Carbamidomethyl) Mitochondrial import N-Term(Dimethyl); inner membrane AEACFVNCVER Q9WVA2 C4(Carbamidomethyl); 2 1382.612 2.65 translocase subunit Tim8 C8(Carbamidomethyl) A Mitochondrial import N-Term(Dimethyl:2H(6)13C(2)); inner membrane AEACFVNCVER Q9WVA2 C4(Carbamidomethyl); 4 1390.663 2.75 translocase subunit Tim8 C8(Carbamidomethyl) A Copper chaperone for AEAGGRATFRIEDK Q9WU84 K14(HeavyDimethyl) 1 1556.853 1.99 superoxide dismutase Alpha-tocopherol N-Term(Dimethyl); AECPELSADLRPR A8Y5P0 transfer protein 1 1541.769 2.27 C3(Carbamidomethyl) (Fragment) Alpha-tocopherol N-Term(Dimethyl:2H(6)13C(2)); AECPELSADLRPR A8Y5P0 transfer protein 1 1549.822 2.11 C3(Carbamidomethyl) (Fragment) N-Term(Dimethyl); NADP-dependent malic AECSAEQCYK P06801 C3(Carbamidomethyl); 5 1301.547 2.80 enzyme C8(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NADP-dependent malic C3(Carbamidomethyl); AECSAEQCYK P06801 4 1317.636 2.65 enzyme C8(Carbamidomethyl); K10(HeavyDimethyl) Methylmalonate- semialdehyde N-Term(Dimethyl); AEMDAAVESCK Q9EQ20 dehydrogenase 1 1266.571 2.38 C10(Carbamidomethyl); K11(Dimethyl) [acylating], mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl); AEMDAAVESCKR Q9EQ20 dehydrogenase 3 1422.668 2.40 C10(Carbamidomethyl); K11(Dimethyl) [acylating], mitochondrial Ubiquitin carboxyl- N-Term(Dimethyl:2H(6)13C(2)); AEMELLISDEAGR Q8C6M1 1 1485.777 2.57 terminal hydrolase 20 M3(Oxidation) AERILQACGGHSLGAYSISSGIQPIRED Alanine Q8QZR5 C8(Carbamidomethyl) 2 3844.973 3.28 VAQYIER aminotransferase 1 Carbamoyl-phosphate N-Term(Dimethyl); AERPDGLILGMGGQTALNCGVELFKR Q8C196 synthase [ammonia], 2 2858.507 4.67 C19(Carbamidomethyl); K25(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); AERPDGLILGMGGQTALNCGVELFKR Q8C196 synthase [ammonia], C19(Carbamidomethyl); 1 2874.596 2.68 mitochondrial K25(HeavyDimethyl) N-Term(Dimethyl); AETFTFHSDICTLPEKEK P07724 Serum albumin C11(Carbamidomethyl); K16(Dimethyl); 6 2237.109 3.76 K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); AETFTFHSDICTLPEKEK P07724 Serum albumin 1 2261.243 4.25 K16(HeavyDimethyl); K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- AEYLGSCLLHK Q8JZR0 C7(Carbamidomethyl); 2 1362.801 2.77 CoA ligase 5 K11(HeavyDimethyl) N-Term(Dimethyl); Formimidoyltransferase- AFAACLEAIKLPK Q91XD4 C5(Carbamidomethyl); K10(Dimethyl); 2 1515.919 3.08 cyclodeaminase K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Formimidoyltransferase- C5(Carbamidomethyl); AFAACLEAIKLPK Q91XD4 1 1540.037 2.88 cyclodeaminase K10(HeavyDimethyl); K13(HeavyDimethyl) N-Term(Dimethyl); Formimidoyltransferase- AFAACLEAIKLPKNTPEER Q91XD4 C5(Carbamidomethyl); K10(Dimethyl); 1 2242.234 2.38 cyclodeaminase K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Formimidoyltransferase- C5(Carbamidomethyl); AFAACLEAIKLPKNTPEER Q91XD4 1 2266.358 2.43 cyclodeaminase K10(HeavyDimethyl); K13(HeavyDimethyl) Nuclear receptor-binding AFAAHEEKIQTMFEQLALVDHPNIVK Q91V36 K8(Dimethyl); K26(Dimethyl) 2 3035.644 2.45 protein 2 Carbamoyl-phosphate AFAMTNQILVER Q8C196 synthase [ammonia], M4(Oxidation) 2 1408.724 2.26 mitochondrial AFASSSYLIAHLR Q3URI6 Protein Zfp560 N-Term(Dimethyl) 1 1463.790 2.09 Propionyl-CoA N-Term(Dimethyl); AFDNDVDALCNLR E9Q1J7 carboxylase beta chain, 1 1550.731 2.42 C10(Carbamidomethyl) mitochondrial Propionyl-CoA AFDNDVDALCNLREFFNFLPLSSQDPA N-Term(Dimethyl:2H(6)13C(2)); E9Q1J7 carboxylase beta chain, 1 3517.766 4.64 PIR C10(Carbamidomethyl) mitochondrial AFGPQDTTTGGLEQDEMDQTPPARSE Phosphatase and actin A2AHM4 M17(Oxidation) 1 4066.962 2.61 PLVSGIRTPPVR regulator N-Term(Dimethyl); AFIDCCNHITK P01027 Complement C3 C5(Carbamidomethyl); 3 1434.687 2.23 C6(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); AFIDCCNHITK P01027 Complement C3 1 1450.775 2.30 C6(Carbamidomethyl); K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein C23(Carbamidomethyl); AFLWRAVTALTSDWTTFAFISTCSATV Q8C888 C130032M10Rik C30(Carbamidomethyl); 1 4219.106 3.22 WACSMLSCK (Fragment) C35(Carbamidomethyl); K36(HeavyDimethyl) Thioredoxin-dependent N-Term(Dimethyl); AFQFVETHGEVCPANWTPESPTIKPSP P20108 peroxide reductase, C12(Carbamidomethyl); K24(Dimethyl); 1 3497.735 3.65 TASK mitochondrial K31(Dimethyl) Dimethylglycine N-Term(Dimethyl); AFRAWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, 2 2961.402 3.97 C11(Carbamidomethyl); K25(Dimethyl) mitochondrial Dimethylglycine N-Term(Dimethyl:2H(6)13C(2)); AFRAWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, C11(Carbamidomethyl); 1 2977.491 3.36 mitochondrial K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dimethylglycine C11(Carbamidomethyl); AFRAWGSEMNCDTNPLEAGLEYFVKL Q9DBT9 dehydrogenase, K25(HeavyDimethyl); 1 4133.241 3.28 NKPADFIGK mitochondrial K28(HeavyDimethyl); K35(HeavyDimethyl) N-Term(Dimethyl); K12(Dimethyl); S-formylglutathione AFSGYLGPDESKWKAYDATCLVK H3BJP2 K14(Dimethyl); C20(Carbamidomethyl); 2 2718.385 2.78 hydrolase (Fragment) K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K12(HeavyDimethyl); S-formylglutathione AFSGYLGPDESKWKAYDATCLVK H3BJP2 K14(HeavyDimethyl); 2 2750.537 2.91 hydrolase (Fragment) C20(Carbamidomethyl); K23(HeavyDimethyl) Isoform 3 of N-Term(Dimethyl); AFSSLNTLPEDLRPIVPLFCSVLTK Q8K411-3 Presequence protease, 1 2873.587 2.89 C20(Carbamidomethyl); K25(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); AFSTCSSHILVVSLFYGTALFTYLQPKS C5(Carbamidomethyl); E9PVJ7 Olfactory receptor 1 4127.206 3.15 SHTPDTDK K27(HeavyDimethyl); K36(HeavyDimethyl) Trifunctional purine N-Term(Dimethyl); AFTNPEDACSFITSANFPALVVK D6RCG1 biosynthetic protein 1 2555.300 2.88 C9(Carbamidomethyl); K23(Dimethyl) adenosine-3 Trifunctional purine N-Term(Dimethyl:2H(6)13C(2)); AFTNPEDACSFITSANFPALVVK D6RCG1 biosynthetic protein C9(Carbamidomethyl); 1 2571.402 3.61 adenosine-3 K23(HeavyDimethyl) Acyl-coenzyme A N-Term(Dimethyl); AFTTWTANAGIEECR A2A848 23 1754.808 5.48 oxidase (Fragment) C14(Carbamidomethyl) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); AFTTWTANAGIEECR A2A848 25 1762.851 5.47 oxidase (Fragment) C14(Carbamidomethyl) Long-chain specific acyl- N-Term(Dimethyl); AFVDSCLQLHETK P51174 CoA dehydrogenase, 16 1603.804 4.38 C6(Carbamidomethyl); K13(Dimethyl) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); AFVDSCLQLHETK P51174 CoA dehydrogenase, C6(Carbamidomethyl); 7 1619.899 3.89 mitochondrial K13(HeavyDimethyl)

Long-chain specific acyl- N-Term(Dimethyl); AFVDSCLQLHETKR P51174 CoA dehydrogenase, 3 1759.909 3.68 C6(Carbamidomethyl); K13(Dimethyl) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); AFVDSCLQLHETKR P51174 CoA dehydrogenase, C6(Carbamidomethyl); 2 1775.996 3.64 mitochondrial K13(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain specific acyl- C6(Carbamidomethyl); AFVDSCLQLHETKRLDSGSASMAK P51174 CoA dehydrogenase, 1 2759.512 2.60 K13(HeavyDimethyl); mitochondrial K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AFVEVNEEGTEAAAATAGMMTVR Q60854 Serpin B6 1 2423.169 2.69 M19(Oxidation); M20(Oxidation) Peroxisomal carnitine O- N-Term(Dimethyl); AFVFDVLHEGCLITPPELLR Q9DC50 6 2354.258 4.15 octanoyltransferase C11(Carbamidomethyl) Peroxisomal carnitine O- N-Term(Dimethyl:2H(6)13C(2)); AFVFDVLHEGCLITPPELLR Q9DC50 2 2362.304 3.72 octanoyltransferase C11(Carbamidomethyl) Rho-related BTB N-Term(Dimethyl:2H(6)13C(2)); AFVSIQEEMAEDPLTFK Q91V93 domain-containing 2 2027.124 2.80 K17(HeavyDimethyl) protein 2 Delta(3,5)-Delta(2,4)- N-Term(Dimethyl:2H(6)13C(2)); AFWRELVECFQK O35459 dienoyl-CoA isomerase, C9(Carbamidomethyl); 1 1684.946 2.45 mitochondrial K12(HeavyDimethyl)

Ornithine N-Term(Dimethyl); K16(Dimethyl); AFYNNVLGEYEEYITKLFNYNKVLPM P29758 aminotransferase, K22(Dimethyl); C37(Carbamidomethyl); 5 4502.275 4.88 NTGVEAGETACK mitochondrial K38(Dimethyl) Ornithine N-Term(Dimethyl); K16(Dimethyl); AFYNNVLGEYEEYITKLFNYNKVLPM P29758 aminotransferase, K22(Dimethyl); M26(Oxidation); 1 4518.251 3.62 NTGVEAGETACK mitochondrial C37(Carbamidomethyl); K38(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ornithine K16(HeavyDimethyl); AFYNNVLGEYEEYITKLFNYNKVLPM P29758 aminotransferase, K22(HeavyDimethyl); 3 4534.419 5.92 NTGVEAGETACK mitochondrial C37(Carbamidomethyl); K38(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ornithine K16(HeavyDimethyl); AFYNNVLGEYEEYITKLFNYNKVLPM P29758 aminotransferase, K22(HeavyDimethyl); M26(Oxidation); 1 4550.413 4.45 NTGVEAGETACK mitochondrial C37(Carbamidomethyl); K38(HeavyDimethyl) RIKEN cDNA N-Term(Dimethyl); AGACVTSESTVMR S4R1U9 1300018J18, isoform 1 1396.650 2.39 C4(Carbamidomethyl) CRA_b N-Term(Dimethyl:2H(6)13C(2)); AGACVTSESTVMR Q9DBC0 Selenoprotein O 1 1404.700 2.44 C4(Carbamidomethyl) N-Term(Dimethyl); K8(Dimethyl); AGAEREFKGLGDCLVK P51881 ADP/ATP translocase 2 1 1833.988 2.59 C13(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl); AGAIAPCEVTVPAQNTGLGPEK E9Q070 Uncharacterized protein 8 2236.161 5.00 C7(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AGAIAPCEVTVPAQNTGLGPEK E9Q070 Uncharacterized protein C7(Carbamidomethyl); 7 2252.255 5.03 K22(HeavyDimethyl) N-Term(Dimethyl); AGAIAPCEVTVPAQNTGLGPEKTSFFQ E9Q070 Uncharacterized protein C7(Carbamidomethyl); K22(Dimethyl); 3 3558.894 2.92 ALGITTK K34(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AGAIAPCEVTVPAQNTGLGPEKTSFFQ C7(Carbamidomethyl); E9Q070 Uncharacterized protein 1 3583.043 2.73 ALGITTK K22(HeavyDimethyl); K34(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AGALEGVPISGCLGDQSAALVGQMCF Isoform 1 of Glycerol C12(Carbamidomethyl); Q64516-1 2 3307.681 2.98 QDGQAK kinase C25(Carbamidomethyl); K32(HeavyDimethyl) 4- N-Term(Dimethyl); AGAPPGLFNVVQGGAATGQFLCHHR Q9JLJ2 trimethylaminobutyralde 3 2590.305 3.23 C22(Carbamidomethyl) hyde dehydrogenase

Betaine--homocysteine S- AGASIVGVNCHFDPSVSLQTVK O35490 C10(Carbamidomethyl); K22(Dimethyl) 1 2314.189 2.41 methyltransferase 1

Betaine--homocysteine S-N-Term(Dimethyl); AGASIVGVNCHFDPSVSLQTVK O35490 20 2342.217 5.58 methyltransferase 1 C10(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- AGASIVGVNCHFDPSVSLQTVK O35490 C10(Carbamidomethyl); 39 2358.309 6.08 methyltransferase 1 K22(HeavyDimethyl) N-Term(Dimethyl); Betaine--homocysteine S- AGASIVGVNCHFDPSVSLQTVKLMK O35490 C10(Carbamidomethyl); K22(Dimethyl); 5 2742.463 4.60 methyltransferase 1 K25(Dimethyl) N-Term(Dimethyl); Betaine--homocysteine S- AGASIVGVNCHFDPSVSLQTVKLMK O35490 C10(Carbamidomethyl); K22(Dimethyl); 1 2758.456 3.41 methyltransferase 1 M24(Oxidation); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-C10(Carbamidomethyl); AGASIVGVNCHFDPSVSLQTVKLMK O35490 3 2766.610 3.19 methyltransferase 1 K22(HeavyDimethyl); K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-C10(Carbamidomethyl); AGASIVGVNCHFDPSVSLQTVKLMK O35490 2 2782.594 2.70 methyltransferase 1 K22(HeavyDimethyl); M24(Oxidation); K25(HeavyDimethyl) N-Term(Dimethyl); AGASIVGVNCHFDPSVSLQTVKLMKE Betaine--homocysteine S- O35490 C10(Carbamidomethyl); K22(Dimethyl); 8 3468.840 4.52 GLEAAR methyltransferase 1 K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AGASIVGVNCHFDPSVSLQTVKLMKE Betaine--homocysteine S-C10(Carbamidomethyl); O35490 4 3492.950 4.01 GLEAAR methyltransferase 1 K22(HeavyDimethyl); K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AGASIVGVNCHFDPSVSLQTVKLMKE Betaine--homocysteine S-C10(Carbamidomethyl); O35490 1 3508.975 3.37 GLEAAR methyltransferase 1 K22(HeavyDimethyl); M24(Oxidation); K25(HeavyDimethyl)

N-Term(Dimethyl); Tumor necrosis factor C3(Carbamidomethyl); M4(Oxidation); AGCMYFGTPENKGFCTLCFIEYR Q60769 3 2893.258 3.07 alpha-induced protein 3 K12(Dimethyl); C15(Carbamidomethyl); C18(Carbamidomethyl) Delta-aminolevulinic N-Term(Dimethyl); AGCQVVAPSDMMDGRVEAIK P10518 1 2190.073 2.74 acid dehydratase C3(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Delta-aminolevulinic C3(Carbamidomethyl); AGCQVVAPSDMMDGRVEAIKAALLK P10518 1 2738.595 2.63 acid dehydratase K20(HeavyDimethyl); K25(HeavyDimethyl) Cystathionine gamma- N-Term(Dimethyl); AGDEIICMDEVYGGTNR Q8VCN5 5 1927.844 4.76 lyase C7(Carbamidomethyl) Cystathionine gamma- N-Term(Dimethyl:2H(6)13C(2)); AGDEIICMDEVYGGTNR Q8VCN5 3 1935.896 4.82 lyase C7(Carbamidomethyl) Cystathionine gamma- N-Term(Dimethyl:2H(6)13C(2)); AGDEIICMDEVYGGTNR Q8VCN5 1 1951.884 3.94 lyase C7(Carbamidomethyl); M8(Oxidation) Ventricular zone- N-Term(Dimethyl:2H(6)13C(2)); AGDLFSLDDAEIEDSLTEALEQIK A1A535 expressed PH domain- 4 2694.433 3.50 K24(HeavyDimethyl) containing protein 1 Catenin beta-1 N-Term(Dimethyl:2H(6)13C(2)); AGDREDITEPAICALR F7BAC9 2 1822.951 2.19 (Fragment) C13(Carbamidomethyl) N-Term(Dimethyl); Alcohol dehydrogenase AGDTVIPLYIPQCGECK P28474 C13(Carbamidomethyl); 5 1976.982 2.88 class-3 C16(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase C13(Carbamidomethyl); AGDTVIPLYIPQCGECK P28474 2 1993.078 3.08 class-3 C16(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl); RNA-binding protein AGDWQCPNPGCGNQNFAWR Q5SUT0 C6(Carbamidomethyl); 1 2262.947 3.47 EWS C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); RNA-binding protein AGDWQCPNPGCGNQNFAWR Q5SUT0 C6(Carbamidomethyl); 1 2271.006 3.54 EWS C11(Carbamidomethyl) AGESSDDVTNSDSIIDWLNSVRQTGNT E3 ubiquitin-protein Q9WTV7 N-Term(Dimethyl) 1 3166.511 2.97 TR ligase RLIM N-Term(Dimethyl); AGESVLVHGASGGVGLATCQIAR P47199 Quinone oxidoreductase 14 2238.162 6.66 C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AGESVLVHGASGGVGLATCQIAR P47199 Quinone oxidoreductase 10 2246.210 5.90 C19(Carbamidomethyl) Actin, gamma-enteric AGFAGDDAPR D3YZY0 smooth muscle 1 976.448 1.89 (Fragment) N-Term(Dimethyl); Heat shock 70 kDa AGGIETIANEYSDRCTPACVSFGPK Q61316 C15(Carbamidomethyl); 2 2756.297 3.67 protein 4 C19(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock 70 kDa C15(Carbamidomethyl); AGGIETIANEYSDRCTPACVSFGPK Q61316 5 2772.384 3.40 protein 4 C19(Carbamidomethyl); K25(HeavyDimethyl) Alpha-aminoadipic N-Term(Dimethyl); AGGILQEDITEACLILGVK Q99K67 semialdehyde synthase, 2 2056.146 2.64 C13(Carbamidomethyl); K19(Dimethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); AGGILQEDITEACLILGVK Q99K67 semialdehyde synthase, C13(Carbamidomethyl); 1 2072.228 4.78 mitochondrial K19(HeavyDimethyl)

Alpha-aminoadipic N-Term(Dimethyl); AGGILQEDITEACLILGVKRPPEEK Q99K67 semialdehyde synthase, C13(Carbamidomethyl); K19(Dimethyl); 1 2820.567 2.82 mitochondrial K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alpha-aminoadipic C13(Carbamidomethyl); AGGILQEDITEACLILGVKRPPEEK Q99K67 semialdehyde synthase, 1 2844.695 2.91 K19(HeavyDimethyl); mitochondrial K25(HeavyDimethyl) N-Term(Dimethyl); K4(Dimethyl); AGIKVTVAGLAGKDPVQCSR A2A815 Protein DJ-1 (Fragment) 5 2111.195 3.51 K13(Dimethyl); C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); AGIKVTVAGLAGKDPVQCSR A2A815 Protein DJ-1 (Fragment) 4 2135.325 3.77 K13(HeavyDimethyl); C18(Carbamidomethyl) Isoform 2 of AGKPFGPGRVGTAGIGRPTRSQR Q9JLZ6-2 Hypermethylated in K3(Dimethyl) 1 2351.288 2.39 cancer 2 protein N-Term(Dimethyl:2H(6)13C(2)); AGLEKNYCRNPDGDVNGPWCYTTNP K5(HeavyDimethyl); P20918 Plasminogen 1 3126.503 3.08 R C8(Carbamidomethyl); C20(Carbamidomethyl) Uncharacterized protein N-Term(Dimethyl:2H(6)13C(2)); AGLLVWNLIIIICRIFEDGNTVER Q3UPC7 1 2850.582 2.45 KIAA0825 homolog C13(Carbamidomethyl) Succinate N-Term(Dimethyl); dehydrogenase AGLPCQDLEFVQFHPTGIYGAGCLITE C5(Carbamidomethyl); Q8K2B3 [ubiquinone] 1 3394.633 2.86 GCR C23(Carbamidomethyl); flavoprotein subunit, C29(Carbamidomethyl) mitochondrial Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase AGLPCQDLEFVQFHPTGIYGAGCLITE C5(Carbamidomethyl); Q8K2B3 [ubiquinone] 1 3402.665 3.22 GCR C23(Carbamidomethyl); flavoprotein subunit, C29(Carbamidomethyl) mitochondrial Succinate N-Term(Dimethyl); dehydrogenase AGLPCQDLEFVQFHPTGIYGAGCLITE C5(Carbamidomethyl); Q8K2B3 [ubiquinone] 2 4705.267 3.62 GCRGEGGILINSQGER C23(Carbamidomethyl); flavoprotein subunit, C29(Carbamidomethyl) mitochondrial Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase AGLPCQDLEFVQFHPTGIYGAGCLITE C5(Carbamidomethyl); Q8K2B3 [ubiquinone] 1 4713.272 3.09 GCRGEGGILINSQGER C23(Carbamidomethyl); flavoprotein subunit, C29(Carbamidomethyl) mitochondrial Basement membrane- specific heparan sulfate N-Term(Dimethyl:2H(6)13C(2)); AGLSSGFVGCVR B1B0C7 1 1245.673 2.01 proteoglycan core C10(Carbamidomethyl) protein 3-ketoacyl-CoA thiolase N-Term(Dimethyl); AGLTVNDIDIFEINEAFASQAVYCVEK Q921H8 1 3072.539 3.79 A, peroxisomal C24(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase AGLTVNDIDIFEINEAFASQAVYCVEK Q8VCH0 C24(Carbamidomethyl); 2 3088.651 4.11 B, peroxisomal K27(HeavyDimethyl) Calcium-binding N-Term(Dimethyl); AGQTTYNGVTDCFR Q9QXX4 mitochondrial carrier 1 1617.725 2.70 C12(Carbamidomethyl) protein Aralar2 Calcium-binding N-Term(Dimethyl:2H(6)13C(2)); AGQTTYNGVTDCFR Q9QXX4 mitochondrial carrier 6 1625.769 3.73 C12(Carbamidomethyl) protein Aralar2 Calcium-binding N-Term(Dimethyl); AGQTTYNGVTDCFRK Q9QXX4 mitochondrial carrier 6 1773.857 3.89 C12(Carbamidomethyl); K15(Dimethyl) protein Aralar2 Calcium-binding N-Term(Dimethyl:2H(6)13C(2)); AGQTTYNGVTDCFRK Q9QXX4 mitochondrial carrier C12(Carbamidomethyl); 4 1789.942 3.88 protein Aralar2 K15(HeavyDimethyl) Isoform 2 of Protein N-Term(Dimethyl:2H(6)13C(2)); AGSKHYSAAIAFTLALFSHLINHVNIR Q6ZPY2-2 1 3023.731 2.44 SMG5 K4(HeavyDimethyl) Isoform 2 of von Willebrand factor A N-Term(Dimethyl); AGTAFYIDQCAVR Q8CC88-2 3 1499.726 2.99 domain-containing C10(Carbamidomethyl) protein 8 Isoform 2 of von Willebrand factor A N-Term(Dimethyl:2H(6)13C(2)); AGTAFYIDQCAVR Q8CC88-2 4 1507.773 3.61 domain-containing C10(Carbamidomethyl) protein 8 N-Term(Dimethyl); K4(Dimethyl); Signal peptide, CUB and C5(Carbamidomethyl); AGTKCGQCPPGHHSGDGFKPCQPCPR EGF-like domain- F7A487 C8(Carbamidomethyl); K19(Dimethyl); 1 3936.752 3.13 GTYQPEAGR containing protein 3 C21(Carbamidomethyl); (Fragment) C24(Carbamidomethyl)

Probable N-Term(Dimethyl); AGTTLVECK Q9DBA8 3 1034.550 2.87 imidazolonepropionase C8(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Probable AGTTLVECK Q9DBA8 C8(Carbamidomethyl); 2 1050.640 2.12 imidazolonepropionase K9(HeavyDimethyl) Methionine N-Term(Dimethyl:2H(6)13C(2)); AGVTTEEIDHAVHLACIAR Q8BP48 1 2099.118 2.63 aminopeptidase 1 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AHCLSEVEHDTMPADLPAIAADFVED C3(Carbamidomethyl); P07724 Serum albumin 1 3569.750 2.69 QEVCK C30(Carbamidomethyl); K31(HeavyDimethyl) Methylmalonyl-CoA N-Term(Dimethyl); AHCQTSGWSLTEQDPYNNIVR P16332 1 2504.161 2.69 mutase, mitochondrial C3(Carbamidomethyl) Methylmalonyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AHCQTSGWSLTEQDPYNNIVR P16332 1 2512.203 3.05 mutase, mitochondrial C3(Carbamidomethyl) Ferrochelatase, N-Term(Dimethyl); AIAFTQYPQYSCSTTGSSLNAIYR P22315 3 2727.314 4.79 mitochondrial C12(Carbamidomethyl) Ferrochelatase, N-Term(Dimethyl:2H(6)13C(2)); AIAFTQYPQYSCSTTGSSLNAIYR P22315 4 2735.354 5.31 mitochondrial C12(Carbamidomethyl) N-Term(Dimethyl); AIAQSSVIFNPCLFGR Q8VCC2 Liver carboxylesterase 1 9 1807.940 4.54 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AIAQSSVIFNPCLFGR Q8VCC2 Liver carboxylesterase 1 1 1816.002 3.01 C12(Carbamidomethyl) DnaJ homolog subfamily N-Term(Dimethyl); AIDMCPNNASYYGNR A2A5E1 2 1773.756 2.77 C member 7 (Fragment) C5(Carbamidomethyl)

DnaJ homolog subfamily N-Term(Dimethyl:2H(6)13C(2)); AIDMCPNNASYYGNR A2A5E1 2 1781.801 3.20 C member 7 (Fragment) C5(Carbamidomethyl) 7-dehydrocholesterol N-Term(Dimethyl); AIECSYTSADGLK O88455 1 1470.705 2.17 reductase C4(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 7-dehydrocholesterol AIECSYTSADGLK O88455 C4(Carbamidomethyl); 1 1486.802 2.83 reductase K13(HeavyDimethyl) N-Term(Dimethyl); Isoform 2 of Nitrilase AIESQCYVIAAAQCGR Q8VDK1-2 C6(Carbamidomethyl); 2 1824.867 5.34 homolog 1 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Nitrilase AIESQCYVIAAAQCGR Q8VDK1-2 C6(Carbamidomethyl); 4 1832.913 5.24 homolog 1 C14(Carbamidomethyl) AIFASGSPFDPVTLPDGRTLFPGQGNNS NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); P06801 2 4557.370 5.33 YVFPGVALGVVACGLR enzyme C41(Carbamidomethyl) Thiosulfate N-Term(Dimethyl); K6(Dimethyl); AIFQDKKVDLSQPLIATCR P52196 3 2287.288 3.34 sulfurtransferase K7(Dimethyl); C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Thiosulfate K6(HeavyDimethyl); AIFQDKKVDLSQPLIATCR P52196 2 2311.417 2.60 sulfurtransferase K7(HeavyDimethyl); C18(Carbamidomethyl) N-Term(Dimethyl); AIGAVPLIQGEYMIPCEK F6Y6L6 Cathepsin D (Fragment) 2 2045.078 3.46 C16(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AIGAVPLIQGEYMIPCEK F6Y6L6 Cathepsin D (Fragment) C16(Carbamidomethyl); 2 2061.169 3.08 K18(HeavyDimethyl) N-Term(Dimethyl); AIGAVPLIQGEYMIPCEKVSSLPTVYLK F6Y6L6 Cathepsin D (Fragment) C16(Carbamidomethyl); K18(Dimethyl); 1 3160.739 3.07 K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C16(Carbamidomethyl); AIGAVPLIQGEYMIPCEKVSSLPTVYLK F6Y6L6 Cathepsin D (Fragment) 1 3184.873 3.29 K18(HeavyDimethyl); K28(HeavyDimethyl) Isoform 2 of AILEKNFSFLSKGAGQTNVPNLVNTM K5(HeavyDimethyl); Q8BYH8-2 Chromodomain-helicase- 1 3394.910 3.19 MELR K12(HeavyDimethyl) DNA-binding protein 9

D-beta-hydroxybutyrate N-Term(Dimethyl); AILITGCDSGFGFSLAK Q80XN0 dehydrogenase, 4 1812.946 3.57 C7(Carbamidomethyl); K17(Dimethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); AILITGCDSGFGFSLAK Q80XN0 dehydrogenase, C7(Carbamidomethyl); 1 1829.054 3.59 mitochondrial K17(HeavyDimethyl) Leukotriene A-4 N-Term(Dimethyl); AILPCQDTPSVK P24527 3 1384.749 2.54 hydrolase C5(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Leukotriene A-4 AILPCQDTPSVK P24527 C5(Carbamidomethyl); 1 1400.835 2.12 hydrolase K12(HeavyDimethyl) Isoform 3 of E3 AILTMLVQSIQELSVNMEVQMRTAPLI A2AN08-3 ubiquitin-protein ligase M5(Oxidation) 1 3384.833 2.79 LAR UBR4 AIMRSFSLLQEAIIPYIPTLITQLTQK F6ZEW4 Exportin-2 (Fragment) N-Term(Dimethyl); K27(Dimethyl) 1 3144.829 2.79 Dipeptidyl peptidase 1 N-Term(Dimethyl); K7(Dimethyl); AINTVQKSWTATAYKEYEK D3Z220 1 2343.227 2.38 (Fragment) K15(Dimethyl); K19(Dimethyl) Indolethylamine N- N-Term(Dimethyl); AIQDAGCQVLK P40936 2 1258.676 2.40 methyltransferase C7(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Indolethylamine N- AIQDAGCQVLK P40936 C7(Carbamidomethyl); 10 1274.767 3.45 methyltransferase K11(HeavyDimethyl) N-Term(Dimethyl); AIQSLTDTCSDDLSVVTDCMEHALTAC C9(Carbamidomethyl); O88451 Retinol dehydrogenase 7 4 3431.533 4.02 HPR C19(Carbamidomethyl); C27(Carbamidomethyl) N-Term(Dimethyl); AIQSLTDTCSDDLSVVTDCMEHALTAC C9(Carbamidomethyl); O88451 Retinol dehydrogenase 7 1 3447.520 3.30 HPR C19(Carbamidomethyl); M20(Oxidation); C27(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AIQSLTDTCSDDLSVVTDCMEHALTAC C9(Carbamidomethyl); O88451 Retinol dehydrogenase 7 3 3439.572 3.46 HPR C19(Carbamidomethyl); C27(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AIQSLTDTCSDDLSVVTDCMEHALTAC C9(Carbamidomethyl); O88451 Retinol dehydrogenase 7 3 3455.567 3.77 HPR C19(Carbamidomethyl); M20(Oxidation); C27(Carbamidomethyl)

AISESGVSLTAALITTDVKPIAGLVATL N-Term(Dimethyl); K19(Dimethyl); Q8VCT4 Carboxylesterase 1D 6 3227.831 5.91 SGCK C31(Carbamidomethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AISESGVSLTAALITTDVKPIAGLVATL K19(HeavyDimethyl); Q8VCT4 Carboxylesterase 1D 1 3251.962 6.13 SGCK C31(Carbamidomethyl); K32(HeavyDimethyl) Formimidoyltransferase- N-Term(Dimethyl); AISQTPGCVLLDVDAGPSTNR Q91XD4 9 2199.112 6.06 cyclodeaminase C8(Carbamidomethyl) Formimidoyltransferase- N-Term(Dimethyl:2H(6)13C(2)); AISQTPGCVLLDVDAGPSTNR Q91XD4 6 2207.149 5.70 cyclodeaminase C8(Carbamidomethyl) N-Term(Dimethyl); AISQTPGCVLLDVDAGPSTNRTVYTFV Formimidoyltransferase- Q91XD4 C8(Carbamidomethyl); 2 4484.234 3.55 GQPECVVEGALHAAR cyclodeaminase C32(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AISQTPGCVLLDVDAGPSTNRTVYTFV Formimidoyltransferase- Q91XD4 C8(Carbamidomethyl); 4 4492.296 4.18 GQPECVVEGALHAAR cyclodeaminase C32(Carbamidomethyl) Poly(rC)-binding protein N-Term(Dimethyl); AITIAGVPQSVTECVK P60335 7 1728.953 3.03 1 C14(Carbamidomethyl); K16(Dimethyl)

N-Term(Dimethyl); AITIASAVNCPLYVVHVMSK Q9EQF5 Dihydropyrimidinase 5 2229.220 4.60 C10(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl); AIVDALPPPCESACSLPTDVDKWFHQQ Inorganic C10(Carbamidomethyl); Q9D819 1 3407.684 3.56 KN pyrophosphatase C14(Carbamidomethyl); K22(Dimethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); AIVDALPPPCESACSLPTDVDKWFHQQ Inorganic Q9D819 C14(Carbamidomethyl); 1 3431.808 3.22 KN pyrophosphatase K22(HeavyDimethyl); K28(HeavyDimethyl) Acyl-coenzyme A synthetase ACSM1, N-Term(Dimethyl); AIVTTASLVPEVESVASECPDLK D3Z106 3 2471.311 3.50 mitochondrial C19(Carbamidomethyl); K23(Dimethyl) (Fragment) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); synthetase ACSM1, AIVTTASLVPEVESVASECPDLK D3Z106 C19(Carbamidomethyl); 5 2487.389 3.44 mitochondrial K23(HeavyDimethyl) (Fragment) Acyl-coenzyme A N-Term(Dimethyl); synthetase ACSM1, AIVTTASLVPEVESVASECPDLKTK D3Z106 C19(Carbamidomethyl); K23(Dimethyl); 1 2728.475 2.81 mitochondrial K25(Dimethyl) (Fragment) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); synthetase ACSM1, C19(Carbamidomethyl); AIVTTASLVPEVESVASECPDLKTK D3Z106 1 2752.597 3.85 mitochondrial K23(HeavyDimethyl); (Fragment) K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NADP-dependent malic AIVVTDGERILGLGDLGCNGMGIPVGK P06801 C18(Carbamidomethyl); 2 2783.533 3.23 enzyme K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Superoxide dismutase C18(Carbamidomethyl); AIWNVINWENVTERYTACKK P09671 1 2603.483 2.52 [Mn], mitochondrial K19(HeavyDimethyl); K20(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); Choline dehydrogenase, AKADSAYHPSCTCK Q8BJ64 C11(Carbamidomethyl); 1 1679.784 2.60 mitochondrial C13(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Choline dehydrogenase, AKADSAYHPSCTCK Q8BJ64 C11(Carbamidomethyl); 2 1703.916 2.83 mitochondrial C13(Carbamidomethyl); K14(HeavyDimethyl) Alcohol dehydrogenase N-Term(Dimethyl); K2(Dimethyl); AKEFGASECISPQDFSK P28474 14 1984.962 5.64 class-3 C9(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase K2(HeavyDimethyl); AKEFGASECISPQDFSK P28474 11 2009.107 5.12 class-3 C9(Carbamidomethyl); K17(HeavyDimethyl) Succinate-semialdehyde N-Term(Dimethyl); K2(Dimethyl); AKEVGEVLCTDPLVSK Q8BWF0 dehydrogenase, 2 1829.036 3.45 C9(Carbamidomethyl); K16(Dimethyl) mitochondrial

Putative phospholipase AKIFQRDQSLVEDMDAMVR Q3TCN2 K2(HeavyDimethyl); M17(Oxidation) 1 2304.159 2.46 B-like 2 60S ribosomal protein N-Term(Dimethyl); K2(Dimethyl); AKLVILANNCPALR P62889 1 1608.964 2.47 L30 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Acyl- K2(HeavyDimethyl); AKSIVTSDALAPQVDAISADCPSLQTK Q8BGA8-2 coenzyme A synthetase 1 2894.663 3.55 C21(Carbamidomethyl); ACSM5, mitochondrial K27(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); AKTGGTYGEDLGADYNLSQVCDGK P19096 Fatty acid synthase 2 2603.224 3.15 C21(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); AKTGGTYGEDLGADYNLSQVCDGK P19096 Fatty acid synthase 1 2627.352 2.99 C21(Carbamidomethyl); K24(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); AKVAPEEVSEVIFGHVLTAGCGQNPTR F2Z459 Protein Acat3 9 2922.514 5.85 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AKVAPEEVSEVIFGHVLTAGCGQNPTR F2Z459 Protein Acat3 K2(HeavyDimethyl); 2 2938.607 5.44 C21(Carbamidomethyl) Glutamate N-Term(Dimethyl); K2(Dimethyl); AKVYEGSILEADCDILIPAASEK P26443 dehydrogenase 1, 1 2576.356 2.32 C13(Carbamidomethyl); K23(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Glutamate K2(HeavyDimethyl); AKVYEGSILEADCDILIPAASEK P26443 dehydrogenase 1, 3 2600.504 5.17 C13(Carbamidomethyl); mitochondrial K23(HeavyDimethyl) Glutamate N-Term(Dimethyl); K2(Dimethyl); AKVYEGSILEADCDILIPAASEKQLTK P26443 dehydrogenase 1, C13(Carbamidomethyl); K23(Dimethyl); 3 3074.670 4.61 mitochondrial K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate K2(HeavyDimethyl); AKVYEGSILEADCDILIPAASEKQLTK P26443 dehydrogenase 1, C13(Carbamidomethyl); 1 3106.833 3.17 mitochondrial K23(HeavyDimethyl); K27(HeavyDimethyl) N-Term(Dimethyl); ALAGCDFLTISPK Q93092 Transaldolase 7 1448.777 3.52 C5(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALAGCDFLTISPK Q93092 Transaldolase C5(Carbamidomethyl); 5 1464.871 3.93 K13(HeavyDimethyl) Probable D-lactate N-Term(Dimethyl); ALALGGTCTGEHGIGLGKR Q7TNG8 dehydrogenase, 9 1924.036 4.95 C8(Carbamidomethyl); K18(Dimethyl) mitochondrial Probable D-lactate N-Term(Dimethyl:2H(6)13C(2)); ALALGGTCTGEHGIGLGKR Q7TNG8 dehydrogenase, C8(Carbamidomethyl); 1 1940.126 2.51 mitochondrial K18(HeavyDimethyl) Fructose-bisphosphate N-Term(Dimethyl); ALANSLACQGK P05064 3 1188.636 2.78 aldolase A C8(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALANSLACQGKYTPSGQSGAAASESLF Fructose-bisphosphate P05064 C8(Carbamidomethyl); 1 3443.778 5.21 ISNHAY aldolase A K11(HeavyDimethyl) ALANVNIGSLICNVGAGGPAPAAGAAP 60S acidic ribosomal N-Term(Dimethyl); P47955 2 3838.969 3.77 AGGAAPSTAAAPAEEK protein P1 C12(Carbamidomethyl); K43(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALANVNIGSLICNVGAGGPAPAAGAAP 60S acidic ribosomal P47955 C12(Carbamidomethyl); 1 3855.093 3.09 AGGAAPSTAAAPAEEK protein P1 K43(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALASQLQDSLKDLKAQMQEAMTQEVS K11(HeavyDimethyl); Q64727 Vinculin 1 4244.285 2.82 DVFSDTTTPIK K14(HeavyDimethyl); M17(Oxidation); M21(Oxidation); K37(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); UDP-glucose 6- ALCAVYEHWVPK O70475 C3(Carbamidomethyl); 3 1544.894 3.13 dehydrogenase K12(HeavyDimethyl) N-Term(Dimethyl); UDP-glucose 6- ALCAVYEHWVPKEK O70475 C3(Carbamidomethyl); K12(Dimethyl); 7 1813.963 3.68 dehydrogenase K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); UDP-glucose 6- C3(Carbamidomethyl); ALCAVYEHWVPKEK O70475 4 1838.093 3.22 dehydrogenase K12(HeavyDimethyl); K14(HeavyDimethyl) Vitamin K epoxide N-Term(Dimethyl); ALCDVGTAISCSR Q9CRC0 reductase complex C3(Carbamidomethyl); 4 1437.677 2.76 subunit 1 C11(Carbamidomethyl) Vitamin K epoxide N-Term(Dimethyl:2H(6)13C(2)); ALCDVGTAISCSR Q9CRC0 reductase complex C3(Carbamidomethyl); 1 1445.723 2.49 subunit 1 C11(Carbamidomethyl) ALCHPSSVDSLSTSAATEDHVSMGGW N-Term(Dimethyl); P35492 Histidine ammonia-lyase 2 3028.391 3.25 AAR C3(Carbamidomethyl) ALCHPSSVDSLSTSAATEDHVSMGGW N-Term(Dimethyl:2H(6)13C(2)); P35492 Histidine ammonia-lyase 4 3036.434 3.98 AAR C3(Carbamidomethyl) Mannose-binding N-Term(Dimethyl); ALCSEFQGSVATPR P41317 5 1550.756 3.06 protein C C3(Carbamidomethyl) Mannose-binding N-Term(Dimethyl:2H(6)13C(2)); ALCSEFQGSVATPR P41317 2 1558.802 3.23 protein C C3(Carbamidomethyl) Stress-induced- N-Term(Dimethyl); ALDLDSSCKEAADGYQR Q60864 2 1954.917 2.35 phosphoprotein 1 C8(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Stress-induced- ALDLDSSCKEAADGYQR Q60864 C8(Carbamidomethyl); 1 1971.001 2.48 phosphoprotein 1 K9(HeavyDimethyl) Microsomal triglyceride N-Term(Dimethyl); ALDTCKIER O08601 transfer protein large 1 1161.629 2.09 C5(Carbamidomethyl); K6(Dimethyl) subunit Microsomal triglyceride N-Term(Dimethyl:2H(6)13C(2)); ALDTCKIER O08601 transfer protein large C5(Carbamidomethyl); 1 1177.718 1.99 subunit K6(HeavyDimethyl) ALEDAQIPYSAVEQACVGYVYGDSTS Non-specific lipid- N-Term(Dimethyl); P32020 9 3162.460 6.16 GQR transfer protein C16(Carbamidomethyl) ALEDAQIPYSAVEQACVGYVYGDSTS Non-specific lipid- N-Term(Dimethyl:2H(6)13C(2)); P32020 6 3170.503 6.06 GQR transfer protein C16(Carbamidomethyl) Isocitrate dehydrogenase N-Term(Dimethyl); ALEDVCIETIEAGFMTK O88844 7 1982.983 4.20 [NADP] cytoplasmic C6(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase ALEDVCIETIEAGFMTK O88844 C6(Carbamidomethyl); 1 1999.075 4.63 [NADP] cytoplasmic K17(HeavyDimethyl) Carbamoyl-phosphate ALENNMSLDEIVR Q8C196 synthase [ammonia], M6(Oxidation) 9 1519.743 2.54 mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); ALENNMSLDEIVR Q8C196 synthase [ammonia], 1 1555.823 1.97 M6(Oxidation) mitochondrial N-Term(Dimethyl); Basement membrane- C7(Carbamidomethyl); ALEVEECRCPPGYVGLSCQDCAPGYT specific heparan sulfate B1B0C7 C9(Carbamidomethyl); 3 3172.389 4.84 R proteoglycan core C18(Carbamidomethyl); protein C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Basement membrane- C7(Carbamidomethyl); ALEVEECRCPPGYVGLSCQDCAPGYT specific heparan sulfate B1B0C7 C9(Carbamidomethyl); 1 3180.445 4.14 R proteoglycan core C18(Carbamidomethyl); protein C21(Carbamidomethyl) C5(Carbamidomethyl); C9(Carbamidomethyl); ALFICVASCLLVVNDGNIIHRCSLAK Q9DA11 Lysozyme-like protein 6 1 2979.578 2.89 C22(Carbamidomethyl); K26(HeavyDimethyl) Alcohol dehydrogenase N-Term(Dimethyl); ALGATDCLNPR Q9QYY9 4 1215.611 2.90 4 C7(Carbamidomethyl) Alcohol dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); ALGATDCLNPR Q9QYY9 2 1223.660 2.69 4 C7(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); K3(Dimethyl); ALKPPCDLSMQSVEIAGTTDGIR D3Z041 1 2515.278 3.17 CoA ligase 1 C6(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); K3(Dimethyl); ALKPPCDLSMQSVEIAGTTDGIRR D3Z041 4 2671.382 3.34 CoA ligase 1 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- ALKPPCDLSMQSVEIAGTTDGIRR D3Z041 K3(HeavyDimethyl); 4 2687.464 3.80 CoA ligase 1 C6(Carbamidomethyl) Adenylyl cyclase- N-Term(Dimethyl); ALLATASQCQQPAGNK B1ARS0 associated protein 2 1713.888 4.05 C9(Carbamidomethyl); K16(Dimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); Adenylyl cyclase- ALLATASQCQQPAGNK P40124 C9(Carbamidomethyl); 5 1729.983 3.60 associated protein 1 K16(HeavyDimethyl) Glyoxalase domain- ALLGYADNQCKLELQGIQGAVDHAAA N-Term(Dimethyl); F6ZTG3 containing protein 4 2 3142.615 3.16 FGR C10(Carbamidomethyl); K11(Dimethyl) (Fragment) Recombining binding N-Term(Dimethyl); ALLNDSSCWTIIGTESVEFTFSTSLACT O08674 protein suppressor of C8(Carbamidomethyl); 1 3294.559 2.94 R hairless-like protein C27(Carbamidomethyl) Isoform 2 of Probable D- N-Term(Dimethyl:2H(6)13C(2)); ALLQQCLHAR Q8BHA3-2 tyrosyl-tRNA(Tyr) 1 1245.727 2.16 C6(Carbamidomethyl) deacylase 2 M3(Oxidation); K8(HeavyDimethyl); Dynein heavy chain 17, ALMEDAVKTPNVVEATNKPDLYNK A2A520 K18(HeavyDimethyl); 1 2784.619 2.68 axonemal (Fragment) K24(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl); ALMGLYNGQVLCK Q8BMS1 subunit alpha, 9 1522.814 3.43 C12(Carbamidomethyl); K13(Dimethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl); M3(Oxidation); ALMGLYNGQVLCK Q8BMS1 subunit alpha, 1 1538.804 2.66 C12(Carbamidomethyl); K13(Dimethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); ALMGLYNGQVLCK Q8BMS1 subunit alpha, C12(Carbamidomethyl); 8 1538.901 3.92 mitochondrial K13(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); ALMGLYNGQVLCK Q8BMS1 subunit alpha, M3(Oxidation); C12(Carbamidomethyl); 1 1554.899 2.45 mitochondrial K13(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl); ALMGLYNGQVLCKK Q8BMS1 subunit alpha, C12(Carbamidomethyl); K13(Dimethyl); 5 1678.938 3.41 mitochondrial K14(Dimethyl) Trifunctional enzyme N-Term(Dimethyl); M3(Oxidation); ALMGLYNGQVLCKK Q8BMS1 subunit alpha, C12(Carbamidomethyl); K13(Dimethyl); 1 1694.927 2.32 mitochondrial K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme C12(Carbamidomethyl); ALMGLYNGQVLCKK Q8BMS1 subunit alpha, 1 1703.072 2.45 K13(HeavyDimethyl); mitochondrial K14(HeavyDimethyl) ALMGQLASTSTSFSLMQYSNILK H3BKX8 Integrin alpha-D M3(Oxidation); K23(HeavyDimethyl) 1 2543.339 2.61 ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate N-Term(Dimethyl); K15(Dimethyl); Q91Y97 16 3074.583 6.04 TK aldolase B C25(Carbamidomethyl); K27(Dimethyl)

N-Term(Dimethyl); K15(Dimethyl); ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate Q91Y97 M18(Oxidation); 1 3090.579 4.82 TK aldolase B C25(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate K15(HeavyDimethyl); Q91Y97 2 3098.716 5.16 TK aldolase B C25(Carbamidomethyl); K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate K15(HeavyDimethyl); M18(Oxidation); Q91Y97 2 3114.717 3.47 TK aldolase B C25(Carbamidomethyl); K27(HeavyDimethyl) N-Term(Dimethyl); K15(Dimethyl); ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate Q91Y97 C25(Carbamidomethyl); K27(Dimethyl); 1 3230.711 3.37 TKK aldolase B K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K15(HeavyDimethyl); ALNDHHVYLEGTLLKPNMVTAGHAC Fructose-bisphosphate Q91Y97 C25(Carbamidomethyl); 1 3262.886 3.58 TKK aldolase B K27(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl); Golgi apparatus protein ALNEACESVIQTACK F8WHM5 C6(Carbamidomethyl); 1 1749.836 2.29 1 (Fragment) C14(Carbamidomethyl); K15(Dimethyl) Microtubule-actin cross- ALNEEIINR F6Q750 linking factor 1 1 1071.564 1.93 (Fragment) Electron transfer ALNEGGLQSIPKLTFPGGLLIGCSPGFM flavoprotein-ubiquinone N-Term(Dimethyl); K12(Dimethyl); Q6PF96 2 3396.868 3.95 NVPK oxidoreductase, C23(Carbamidomethyl); K32(Dimethyl) mitochondrial

Electron transfer N-Term(Dimethyl:2H(6)13C(2)); ALNEGGLQSIPKLTFPGGLLIGCSPGFM flavoprotein-ubiquinone K12(HeavyDimethyl); Q6PF96 1 3420.990 3.73 NVPK oxidoreductase, C23(Carbamidomethyl); mitochondrial K32(HeavyDimethyl)

ALNTTSVELQEAQRHLEPPVQAHRER Q3UUY6-2 Isoform 2 of Prominin-2 2 3009.544 2.97 Isoform Cytoplasmic+peroxisom N-Term(Dimethyl); ALNVEPDGTGLTCSLAPNILSQL P99029-2 19 2411.252 3.76 al of Peroxiredoxin-5, C13(Carbamidomethyl) mitochondrial Isoform Cytoplasmic+peroxisom N-Term(Dimethyl:2H(6)13C(2)); ALNVEPDGTGLTCSLAPNILSQL P99029-2 10 2419.293 3.69 al of Peroxiredoxin-5, C13(Carbamidomethyl) mitochondrial Serine ALQAYHLDPQCWGVNVQPYSGSPANF N-Term(Dimethyl); G3UZ26 hydroxymethyltransferas 1 4241.075 4.07 AVYTALVEPHGR C11(Carbamidomethyl) e (Fragment) Serine ALQAYHLDPQCWGVNVQPYSGSPANF N-Term(Dimethyl:2H(6)13C(2)); G3UZ26 hydroxymethyltransferas 1 4249.116 4.32 AVYTALVEPHGR C11(Carbamidomethyl) e (Fragment) Ornithine ALQDPNVAAFMVEPIQGEAGVIVPDPG N-Term(Dimethyl); P29758 aminotransferase, 5 4111.118 5.00 YLTGVRELCTR C36(Carbamidomethyl) mitochondrial Ornithine ALQDPNVAAFMVEPIQGEAGVIVPDPG N-Term(Dimethyl); M11(Oxidation); P29758 aminotransferase, 1 4127.100 4.29 YLTGVRELCTR C36(Carbamidomethyl) mitochondrial Ornithine ALQDPNVAAFMVEPIQGEAGVIVPDPG N-Term(Dimethyl:2H(6)13C(2)); P29758 aminotransferase, 4 4119.141 4.79 YLTGVRELCTR C36(Carbamidomethyl) mitochondrial Ornithine ALQDPNVAAFMVEPIQGEAGVIVPDPG N-Term(Dimethyl:2H(6)13C(2)); P29758 aminotransferase, 1 4135.162 4.16 YLTGVRELCTR M11(Oxidation); C36(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal sarcosine C7(Carbamidomethyl); ALQHIICQLGGTVCDGEK Q9D826 2 2071.153 3.77 oxidase C14(Carbamidomethyl); K18(HeavyDimethyl) N-Term(Dimethyl); ALQHIICQLGGTVCDGEKVVEIRPGLP Peroxisomal sarcosine C7(Carbamidomethyl); Q9D826 2 3470.940 3.25 VTVK oxidase C14(Carbamidomethyl); K18(Dimethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); ALQHIICQLGGTVCDGEKVVEIRPGLP Peroxisomal sarcosine Q9D826 C14(Carbamidomethyl); 1 3495.068 3.09 VTVK oxidase K18(HeavyDimethyl); K31(HeavyDimethyl) Mitochondrial antiviral- N-Term(Dimethyl); ALQICELPGLADQVTR Q8VCF0 2 1811.962 3.21 signaling protein C5(Carbamidomethyl)

Mitochondrial antiviral- N-Term(Dimethyl:2H(6)13C(2)); ALQICELPGLADQVTR Q8VCF0 2 1820.012 3.46 signaling protein C5(Carbamidomethyl) N-Term(Dimethyl); 40S ribosomal protein ALRLDVGNFSWGSECCTR P62242 C15(Carbamidomethyl); 2 2155.976 3.19 S8 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein ALRLDVGNFSWGSECCTR P62242 C15(Carbamidomethyl); 4 2164.048 3.76 S8 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein C15(Carbamidomethyl); ALRLDVGNFSWGSECCTRK P62242 1 2328.220 2.61 S8 C16(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl); ALSCLESSWK P28666 Murinoglobulin-2 1 1236.625 2.16 C4(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALSCLESSWK P28666 Murinoglobulin-2 C4(Carbamidomethyl); 1 1252.714 2.03 K10(HeavyDimethyl) Ornithine N-Term(Dimethyl); ALSGGLYPVSAVLCDDEIMLTIKPGEH P29758 aminotransferase, C14(Carbamidomethyl); K23(Dimethyl); 4 4161.044 4.23 GSTYGGNPLGCR mitochondrial C38(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Ornithine ALSGGLYPVSAVLCDDEIMLTIKPGEH C14(Carbamidomethyl); P29758 aminotransferase, 2 4177.137 3.60 GSTYGGNPLGCR K23(HeavyDimethyl); mitochondrial C38(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); M4(Oxidation); K11(HeavyDimethyl); ALSMEEEDSMKIDEKCVEADEETFESE MAGUK p55 subfamily Q6P7F1 K15(HeavyDimethyl); 1 3981.900 3.27 ELAEAK member 4 C16(Carbamidomethyl); K33(HeavyDimethyl) N-Term(Dimethyl); ALSQPDTVLRELWLGDCDVTNSGCSS Q91VI7 Ribonuclease inhibitor C17(Carbamidomethyl); 1 3872.949 3.18 LANVLLANR C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ALSQPDTVLRELWLGDCDVTNSGCSS Q91VI7 Ribonuclease inhibitor C17(Carbamidomethyl); 1 3880.965 5.11 LANVLLANR C24(Carbamidomethyl) N-Term(Dimethyl); ALTNHTVYCSTK Q91X52 L-xylulose reductase 3 1450.731 2.85 C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALTNHTVYCSTK Q91X52 L-xylulose reductase C9(Carbamidomethyl); 2 1466.824 2.48 K12(HeavyDimethyl) N-Term(Dimethyl); Cytochrome P450 ALTTPCPYQLCALPR Q9JKY7 C6(Carbamidomethyl); 4 1788.913 3.70 CYP2D22 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytochrome P450 ALTTPCPYQLCALPR Q9JKY7 C6(Carbamidomethyl); 7 1796.954 3.54 CYP2D22 C11(Carbamidomethyl) N-Term(Dimethyl); K15(Dimethyl); ALTVPELTQQMFDAKNMMAACDPR Q9D6F9 Tubulin beta-4A chain 1 2794.345 3.00 C21(Carbamidomethyl) ALVGWNSGDGVFCPGGSISNMYAMN Cysteine sulfinic acid N-Term(Dimethyl); Q9DBE0 5 2972.407 5.28 LAR decarboxylase C13(Carbamidomethyl) ALVGWNSGDGVFCPGGSISNMYAMN Cysteine sulfinic acid N-Term(Dimethyl:2H(6)13C(2)); Q9DBE0 5 2980.433 5.31 LAR decarboxylase C13(Carbamidomethyl) N-Term(Dimethyl); ALYDTFSAFGNILSCK V9GXG3 Protein Pabpc4 1 1862.935 2.77 C15(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ALYDTFSAFGNILSCK V9GXG3 Protein Pabpc4 C15(Carbamidomethyl); 1 1879.033 2.59 K16(HeavyDimethyl) PH and SEC7 domain- K7(Dimethyl); K10(Dimethyl); ALYNSIKNEKLEWAVDDEEK E9PUC5 1 2478.295 2.61 containing protein 3 K20(Dimethyl) AMAEVGHFEPVSQVVESVANVIGAMC N-Term(Dimethyl); P00186 Cytochrome P450 1A2 3 3633.833 3.38 FGKNFPR C26(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AMAEVGHFEPVSQVVESVANVIGAMC P00186 Cytochrome P450 1A2 C26(Carbamidomethyl); 1 3649.902 3.57 FGKNFPR K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AMAEVGHFEPVSQVVESVANVIGAMC P00186 Cytochrome P450 1A2 M2(Oxidation); C26(Carbamidomethyl); 2 3665.883 3.44 FGKNFPR K29(HeavyDimethyl)

AMANCQAAQGQYVHTGSSGAAATQS Fructose-bisphosphate N-Term(Dimethyl); Q91Y97 1 3441.545 3.12 LFTASYTY aldolase B C5(Carbamidomethyl)

AMANCQAAQGQYVHTGSSGAAATQS Fructose-bisphosphate N-Term(Dimethyl:2H(6)13C(2)); Q91Y97 3 3449.600 5.34 LFTASYTY aldolase B C5(Carbamidomethyl)

Isoform 2 of Chaperone N-Term(Dimethyl); AMFEEAYSNYCR Q60936-2 activity of bc1 complex- 2 1568.649 2.41 C11(Carbamidomethyl) like, mitochondrial

Isoform 2 of Chaperone N-Term(Dimethyl:2H(6)13C(2)); AMFEEAYSNYCR Q60936-2 activity of bc1 complex- 1 1576.692 2.26 C11(Carbamidomethyl) like, mitochondrial N-Term(Dimethyl:2H(6)13C(2)); AMKEMLLTCGEDTADRPPVPIFEYLG K3(HeavyDimethyl); P11714 Cytochrome P450 2D9 1 4982.710 3.61 VKPGSQGVVLAPYGPEWR C9(Carbamidomethyl); K28(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AMKEVLLTCGEDTADRPQVPIFEYLG K3(HeavyDimethyl); P24456 Cytochrome P450 2D10 1 4981.757 3.04 VKPGSQGVVLAPYGPEWR C9(Carbamidomethyl); K28(HeavyDimethyl) N-Term(Dimethyl); Peroxisomal acyl- AMSSDFCAQGTEICR Q9QXD1 C7(Carbamidomethyl); 6 1760.731 3.69 coenzyme A oxidase 2 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal acyl- AMSSDFCAQGTEICR Q9QXD1 C7(Carbamidomethyl); 3 1768.782 3.61 coenzyme A oxidase 2 C14(Carbamidomethyl) 2,4-dienoyl-CoA N-Term(Dimethyl); AMTTFLSTLGAQCVIASR Q9CQ62 4 1955.008 3.88 reductase, mitochondrial C13(Carbamidomethyl)

2,4-dienoyl-CoA N-Term(Dimethyl); M2(Oxidation); AMTTFLSTLGAQCVIASR Q9CQ62 3 1971.005 3.17 reductase, mitochondrial C13(Carbamidomethyl)

2,4-dienoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AMTTFLSTLGAQCVIASR Q9CQ62 1 1963.050 2.97 reductase, mitochondrial C13(Carbamidomethyl)

2,4-dienoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AMTTFLSTLGAQCVIASR Q9CQ62 2 1979.039 4.31 reductase, mitochondrial M2(Oxidation); C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alpha-2-HS- ANLMHNLGGEEVSVACK P29699 C16(Carbamidomethyl); 1 1901.014 2.38 glycoprotein K17(HeavyDimethyl) NADH-ubiquinone N-Term(Dimethyl); ANPYECGFDPTSSAR P03899 1 1699.730 2.90 oxidoreductase chain 3 C6(Carbamidomethyl)

NADH-ubiquinone N-Term(Dimethyl:2H(6)13C(2)); ANPYECGFDPTSSAR P03899 2 1707.778 2.79 oxidoreductase chain 3 C6(Carbamidomethyl)

N-Term(Dimethyl); K4(Dimethyl); ANVKGYLGPEQLPDCLKGCDVVVIPA Malate dehydrogenase, P08249 C15(Carbamidomethyl); K17(Dimethyl); 1 3305.802 5.11 GVPR mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); ANVKGYLGPEQLPDCLKGCDVVVIPA Malate dehydrogenase, P08249 C15(Carbamidomethyl); 1 3329.920 3.55 GVPR mitochondrial K17(HeavyDimethyl); C19(Carbamidomethyl) N-Term(Dimethyl); K23(Dimethyl); ANVPEELSVWIDPFEVSYQIGEKGVVK Q9JM55 Protein Tob2 1 3116.659 3.02 K27(Dimethyl) N-Term(Dimethyl); K6(Dimethyl); ANVPNKVIQCFAETGQVQK Q68FD5 Clathrin heavy chain 1 5 2215.187 3.20 C10(Carbamidomethyl); K19(Dimethyl)

APCLTTMDTNGKPLYILTYGKLWTRS C3(Carbamidomethyl); K12(Dimethyl); B7ZMZ7 Dip2c protein 1 3343.786 3.07 MK K21(Dimethyl); K28(Dimethyl) K5(Dimethyl); K9(Dimethyl); Cytosolic phospholipase APEGKLQLKTDCCPK Q50L43 C12(Carbamidomethyl); 1 1828.957 2.41 A2 delta C13(Carbamidomethyl); K15(Dimethyl) Zinc finger SWIM APLCQLLDAAVAAYITTSHSRLTHISPR C4(Carbamidomethyl); Q8C7B8 domain-containing 1 4405.355 3.23 HYGDFIEFLGK K39(HeavyDimethyl) protein 4 Exonuclease 3'-5' APRASWEERILQAEVVTVSQEAEWNQI F8WID1 domain-containing K32(Dimethyl) 1 3781.006 3.33 QPFLK protein 2 MKIAA1614 protein APSLQTLHLVSSSHQHRR Q6ZPL5 2 2054.109 2.43 (Fragment) M16(Oxidation); APSPTPGSPRLPETQMMLACAQRVVD Kinesin-like protein Q52KG5 C20(Carbamidomethyl); 1 3584.701 2.83 GCEVASR KIF26A C28(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); AQCPIVER D3YYM6 1 1008.568 2.16 S5 (Fragment) C3(Carbamidomethyl) AQEDSRGVGTPEPTNSAEEPEHAANGS Receptor-type tyrosine- S4R1M0 N-Term(Dimethyl:2H(6)13C(2)) 1 3599.659 2.77 ASPAPTQSS protein phosphatase C Methylcrotonoyl-CoA N-Term(Dimethyl); AQEIALQNRLPCIYLVDSGGANLPR Q3ULD5 carboxylase beta chain, 1 2796.490 2.84 C12(Carbamidomethyl) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); AQEIALQNRLPCIYLVDSGGANLPR Q3ULD5 carboxylase beta chain, 1 2804.532 4.82 C12(Carbamidomethyl) mitochondrial Fructose-1,6- N-Term(Dimethyl); AQGTGELTQLLNSLCTAIK Q9QXD6 5 2074.137 4.79 bisphosphatase 1 C15(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fructose-1,6- AQGTGELTQLLNSLCTAIK Q9QXD6 C15(Carbamidomethyl); 3 2090.211 6.09 bisphosphatase 1 K19(HeavyDimethyl) AQLLSLNESVR Q3UHA3-2 Isoform 2 of Spatacsin 1 1229.691 2.09 N-Term(Dimethyl:2H(6)13C(2)); AQLNIGNVLPVGTMPEGTIVCCLEEKP 60S ribosomal protein C21(Carbamidomethyl); P62918 1 3339.770 3.29 GDR L8 C22(Carbamidomethyl); K26(HeavyDimethyl) AQLYADWRKEHFEAWTFTLDPASAHP Butyrophilin, subfamily A2CG29 K9(Dimethyl) 1 3980.996 3.19 ILAISPDR 3, member A3 Histone-lysine N- AQPPEDLPSEIVDFVLK F6W623 methyltransferase 2B K17(HeavyDimethyl) 1 1933.053 2.23 (Fragment) Sulfite oxidase, N-Term(Dimethyl); K8(Dimethyl); AQVPAEQKELNIICK Q8R086 3 1825.018 3.21 mitochondrial C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sulfite oxidase, K8(HeavyDimethyl); AQVPAEQKELNIICK Q8R086 1 1849.155 2.46 mitochondrial C14(Carbamidomethyl); K15(HeavyDimethyl) AQVPFSSCLEAYGAPEQVDDFWSTAL Ubiquitin carboxyl- N-Term(Dimethyl); Q3U4W8 2 3271.575 3.89 QAK terminal hydrolase C8(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AQVPFSSCLEAYGAPEQVDDFWSTAL Ubiquitin carboxyl- Q3U4W8 C8(Carbamidomethyl); 1 3287.665 3.44 QAK terminal hydrolase K29(HeavyDimethyl) N-Term(Dimethyl); ARAGESVLVHGASGGVGLATCQIAR P47199 Quinone oxidoreductase 1 2465.298 3.47 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ARAGESVLVHGASGGVGLATCQIAR P47199 Quinone oxidoreductase 1 2473.348 4.17 C21(Carbamidomethyl) ARATSRSVETQAQVGPPALSR Q810S7 Cog1 protein N-Term(Dimethyl) 1 2210.202 2.73 Cytosolic 10- ARGQALPEVVAKYQALGAELNVLPFC N-Term(Dimethyl); K12(Dimethyl); Q8R0Y6 formyltetrahydrofolate 1 4353.330 3.51 SQFIPMEVINAPR C26(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); ARGQALPEVVAKYQALGAELNVLPFC Q8R0Y6 formyltetrahydrofolate K12(HeavyDimethyl); 2 4369.420 4.21 SQFIPMEVINAPR dehydrogenase C26(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); ARGQALPEVVAKYQALGAELNVLPFC Q8R0Y6 formyltetrahydrofolate K12(HeavyDimethyl); 1 4385.446 3.39 SQFIPMEVINAPR dehydrogenase C26(Carbamidomethyl); M32(Oxidation) Propionyl-CoA N-Term(Dimethyl); ARICCDLEVLASK E9Q1J7 carboxylase beta chain, C4(Carbamidomethyl); 1 1590.828 2.25 mitochondrial C5(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Propionyl-CoA C4(Carbamidomethyl); ARICCDLEVLASK E9Q1J7 carboxylase beta chain, 2 1606.926 2.62 C5(Carbamidomethyl); mitochondrial K13(HeavyDimethyl) ARPALVVCAMYLIMIGAIVMTMLGNM Trace amine-associated C8(Carbamidomethyl); M26(Oxidation); Q5QD15 1 3963.184 3.18 AVIISIAHFK receptor 4 K36(Dimethyl) 5-azacytidine-induced ARQTGPPQEDILQGR D3Z7S3 N-Term(Dimethyl) 1 1693.877 2.26 protein 2 (Fragment) ARVANYQRDGPMCMHDNQGGAPNY N-Term(Dimethyl); P24270 Catalase 1 4154.810 3.45 YPNSFSAPEQQR C13(Carbamidomethyl) ARVANYQRDGPMCMHDNQGGAPNY N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 5 4162.887 5.52 YPNSFSAPEQQR C13(Carbamidomethyl) Guanine nucleotide- binding protein N-Term(Dimethyl); ASADLMSYCEEHAR Q9DAS9 5 1667.714 3.16 G(I)/G(S)/G(O) subunit C9(Carbamidomethyl) gamma-12 Guanine nucleotide- binding protein N-Term(Dimethyl:2H(6)13C(2)); ASADLMSYCEEHAR Q9DAS9 1 1675.761 2.73 G(I)/G(S)/G(O) subunit C9(Carbamidomethyl) gamma-12 Stromal cell-derived N-Term(Dimethyl); ASAGLVTCGSVLK Q9ESP1 3 1318.741 2.34 factor 2-like protein 1 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Stromal cell-derived ASAGLVTCGSVLK Q9ESP1 C8(Carbamidomethyl); 2 1334.831 2.38 factor 2-like protein 1 K13(HeavyDimethyl) N-Term(Dimethyl); ASAGPQPLLVQSCK P26039 Talin-1 1 1511.818 2.15 C13(Carbamidomethyl); K14(Dimethyl) Glutaryl-CoA ASATGMIIMDSVEVPEENVLPNVSSLA N-Term(Dimethyl:2H(6)13C(2)); Q60759 dehydrogenase, 1 3882.976 4.11 GPFGCLNTAR C32(Carbamidomethyl) mitochondrial 3'(2'),5'-bisphosphate N-Term(Dimethyl); ASAYVFASPGCK D3Z0E6 6 1313.653 3.25 nucleotidase 1 C11(Carbamidomethyl); K12(Dimethyl)

Electron transfer flavoprotein-ubiquinone N-Term(Dimethyl); ASCDAQTYGIGLK Q6PF96 5 1439.721 2.63 oxidoreductase, C3(Carbamidomethyl); K13(Dimethyl) mitochondrial

Electron transfer N-Term(Dimethyl:2H(6)13C(2)); flavoprotein-ubiquinone ASCDAQTYGIGLK Q6PF96 C3(Carbamidomethyl); 6 1455.808 3.19 oxidoreductase, K13(HeavyDimethyl) mitochondrial Sarcosine N-Term(Dimethyl); ASCLPVYR Q99LB7 dehydrogenase, 4 993.515 2.60 C3(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); ASCLPVYR Q99LB7 dehydrogenase, 7 1001.560 2.63 C3(Carbamidomethyl) mitochondrial Acyl-coenzyme A N-Term(Dimethyl); ASEAHCHYVTVK A2A848 2 1457.715 3.03 oxidase (Fragment) C6(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acyl-coenzyme A ASEAHCHYVTVK A2A848 C6(Carbamidomethyl); 1 1473.806 2.85 oxidase (Fragment) K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C6(Carbamidomethyl); Acyl-coenzyme A ASEAHCHYVTVKVFADKLPK A2A848 K12(HeavyDimethyl); 4 2444.501 3.97 oxidase (Fragment) K17(HeavyDimethyl); K20(HeavyDimethyl) N-Term(Dimethyl); Major facilitator ASEIQPLQVTLCWASVASAPLLPPCSSK C12(Carbamidomethyl); Q8CBH5 superfamily domain- 1 3834.009 3.20 HMGNRK C25(Carbamidomethyl); K28(Dimethyl); containing protein 6 M30(Oxidation); K34(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ASEQIYGSPSSSPYECLR D3YX34 Dynactin subunit 1 1 2066.993 2.75 C16(Carbamidomethyl) N-Term(Dimethyl); Eukaryotic translation ASFENNCEVGCFAK D6RG53 C7(Carbamidomethyl); 3 1688.741 3.43 initiation factor 6 C11(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Eukaryotic translation C7(Carbamidomethyl); ASFENNCEVGCFAK D6RG53 4 1704.819 3.40 initiation factor 6 C11(Carbamidomethyl); K14(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-hydroxyanthranilate ASFQPPVCNK Q78JT3 C8(Carbamidomethyl); 1 1219.702 1.97 3,4-dioxygenase K10(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-hydroxyanthranilate C8(Carbamidomethyl); ASFQPPVCNKLMHQEQLK Q78JT3 2 2263.303 3.11 3,4-dioxygenase K10(HeavyDimethyl); K18(HeavyDimethyl) Isovaleryl-CoA N-Term(Dimethyl); ASGAVGLSYGAHSNLCVNQIVR Q9JHI5 dehydrogenase, 3 2301.172 5.88 C16(Carbamidomethyl) mitochondrial Isovaleryl-CoA N-Term(Dimethyl:2H(6)13C(2)); ASGAVGLSYGAHSNLCVNQIVR Q9JHI5 dehydrogenase, 5 2309.215 5.59 C16(Carbamidomethyl) mitochondrial ASGEPVVLSGQITGLTEGQHGFHVHQ Superoxide dismutase N-Term(Dimethyl); P08228 2 4897.328 3.63 YGDNTQGCTSAGPHFNPHSK [Cu-Zn] C34(Carbamidomethyl); K46(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ASGEPVVLSGQITGLTEGQHGFHVHQ Superoxide dismutase P08228 C34(Carbamidomethyl); 2 4913.384 3.81 YGDNTQGCTSAGPHFNPHSK [Cu-Zn] K46(HeavyDimethyl) Isoform 2 of E3 N-Term(Dimethyl); ASGGGECSVQPVGPSAPDTYEVK Q3UIR3-2 ubiquitin-protein ligase 1 2348.106 2.97 C7(Carbamidomethyl); K23(Dimethyl) DTX3L K4(Dimethyl); M10(Oxidation); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S- O35490 C11(Carbamidomethyl); 1 2977.463 3.27 AVR methyltransferase 1 C26(Carbamidomethyl) K4(HeavyDimethyl); M10(Oxidation); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S- O35490 C11(Carbamidomethyl); 1 2985.500 2.79 AVR methyltransferase 1 C26(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S- O35490 C11(Carbamidomethyl); 63 2989.462 7.04 AVR methyltransferase 1 C26(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S-M10(Oxidation); O35490 27 3005.450 6.17 AVR methyltransferase 1 C11(Carbamidomethyl); C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S-K4(HeavyDimethyl); O35490 57 3005.551 7.86 AVR methyltransferase 1 C11(Carbamidomethyl); C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S-K4(HeavyDimethyl); M10(Oxidation); O35490 15 3021.547 5.27 AVR methyltransferase 1 C11(Carbamidomethyl); C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); ASGKPVAATMCIGPEGDLHGVPPGEC Betaine--homocysteine S- O35490 C11(Carbamidomethyl); 2 3381.887 3.38 AVRLVK methyltransferase 1 C26(Carbamidomethyl); K32(HeavyDimethyl) Protein ASIPQLSVLPAQVEVLTSLK A2AC60 K20(Dimethyl) 1 2121.260 2.61 D630003M21Rik Isoform 2 of Clustered N-Term(Dimethyl); K3(Dimethyl); ASKVETTTSLENGGLPSSAETKSEDSIG Q5SW19-2 mitochondria protein K22(Dimethyl); C33(Carbamidomethyl); 2 4595.197 4.13 PEAGCEEEGSSVSGLAK homolog K45(Dimethyl) F-box/WD repeat- ASLNTGFTRLGTDLMAGIPVKER Q9JMJ2 K21(HeavyDimethyl) 1 2483.371 2.30 containing protein 4 Peroxisomal trans-2- N-Term(Dimethyl); ASLPPSSSAEVSAIQCNIR Q3UXD9 9 2015.022 4.60 enoyl-CoA reductase C16(Carbamidomethyl) Peroxisomal trans-2- N-Term(Dimethyl:2H(6)13C(2)); ASLPPSSSAEVSAIQCNIR Q3UXD9 11 2023.062 4.71 enoyl-CoA reductase C16(Carbamidomethyl) ASQAVVVSEAGRGDEEDSVPRR Q2KHI9 DNA helicase MCM9 N-Term(Dimethyl) 1 2342.181 2.67 N-Term(Dimethyl:2H(6)13C(2)); ASRGCFKDTTPDELLSAVLTAVLQDV 3-ketoacyl-CoA thiolase C5(Carbamidomethyl); Q8VCH0 1 3042.757 2.88 K B, peroxisomal K7(HeavyDimethyl); K27(HeavyDimethyl) Short-chain specific acyl- N-Term(Dimethyl); ASSTANLIFEDCR Q07417 CoA dehydrogenase, 3 1511.708 4.01 C12(Carbamidomethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); ASSTANLIFEDCR Q07417 CoA dehydrogenase, 5 1519.756 3.67 C12(Carbamidomethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl); ASSTANLIFEDCRIPK Q07417 CoA dehydrogenase, 2 1877.980 3.59 C12(Carbamidomethyl); K16(Dimethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); ASSTANLIFEDCRIPK Q07417 CoA dehydrogenase, C12(Carbamidomethyl); 1 1894.062 2.20 mitochondrial K16(HeavyDimethyl) Short-chain specific acyl- N-Term(Dimethyl); ASSTANLIFEDCRIPKENLLGEPGMGFK Q07417 CoA dehydrogenase, C12(Carbamidomethyl); K16(Dimethyl); 2 3178.634 3.51 mitochondrial K28(Dimethyl) Short/branched chain N-Term(Dimethyl); specific acyl-CoA ASSTCQLTFENVKVPETNILGK Q9DBL1 C5(Carbamidomethyl); K13(Dimethyl); 6 2520.329 3.71 dehydrogenase, K22(Dimethyl) mitochondrial Short/branched chain N-Term(Dimethyl:2H(6)13C(2)); specific acyl-CoA C5(Carbamidomethyl); ASSTCQLTFENVKVPETNILGK Q9DBL1 3 2544.466 3.45 dehydrogenase, K13(HeavyDimethyl); mitochondrial K22(HeavyDimethyl) N-Term(Dimethyl); ASSVTTFTGEPNMCPR Q9DCT8 Cysteine-rich protein 2 2 1782.813 3.29 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ASSVTTFTGEPNMCPR Q9DCT8 Cysteine-rich protein 2 1 1790.855 3.64 C14(Carbamidomethyl) ASTAELMDFFTISEVCLHQFQYMGKR Dedicator of cytokinesis N-Term(Dimethyl); E9QMR2 1 3854.879 3.66 YIASVR protein 9 C16(Carbamidomethyl); K25(Dimethyl) UDP-glucose 6- N-Term(Dimethyl); ASVGFGGSCFQK O70475 1 1300.630 2.24 dehydrogenase C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); ASVQYLVAAACPWMSAWLCLMMQPS E9QAE3 Protein Btaf1 C19(Carbamidomethyl); 1 4491.319 2.99 HLPIDLNMLLEVK M21(Oxidation); M22(Oxidation); K38(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); ATAEQLKTVMDDFAQFLDTCCK P07724 Serum albumin C20(Carbamidomethyl); 7 2676.270 5.40 C21(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); ATAEQLKTVMDDFAQFLDTCCK P07724 Serum albumin C20(Carbamidomethyl); 9 2700.418 5.22 C21(Carbamidomethyl); K22(HeavyDimethyl) N-Term(Dimethyl); ATAIQVTDISGGCGAMYEIK E9Q705 BolA-like protein 3 C13(Carbamidomethyl); 1 2157.077 2.64 M16(Oxidation); K20(Dimethyl) N-Term(Dimethyl); ATAQEAQSLGGRCVPVVCDSSQESEV Dehydrogenase/reductas Q99L04 C13(Carbamidomethyl); 2 2948.398 3.43 K e SDR family member 1 C18(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATAQEAQSLGGRCVPVVCDSSQESEV Dehydrogenase/reductas C13(Carbamidomethyl); Q99L04 1 2964.498 2.93 K e SDR family member 1 C18(Carbamidomethyl); K27(HeavyDimethyl) COP9 signalosome ATASSSAQEMEQQLAER Q8BV13 N-Term(Dimethyl) 1 1864.863 2.36 complex subunit 7b Proteasome subunit N-Term(Dimethyl); ATCIGNNSAAAVSMLK E9PW69 1 1663.851 2.72 alpha type (Fragment) C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit ATCIGNNSAAAVSMLK E9PW69 C3(Carbamidomethyl); 1 1679.935 2.60 alpha type (Fragment) K16(HeavyDimethyl) Isoform 2 of Enoyl-CoA N-Term(Dimethyl); ATFHTPFSQLGQSPEACSSYTFPK Q9WUR2-2 delta isomerase 2, 8 2744.297 5.00 C17(Carbamidomethyl); K24(Dimethyl) mitochondrial Isoform 2 of Enoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); ATFHTPFSQLGQSPEACSSYTFPK Q9WUR2-2 delta isomerase 2, C17(Carbamidomethyl); 2 2760.379 3.76 mitochondrial K24(HeavyDimethyl) N-Term(Dimethyl); ATIANMCPEYGATAAFFPVDEVSIAYL Cytoplasmic aconitate P28271 C7(Carbamidomethyl); K36(Dimethyl); 1 4289.178 3.17 LQTGREEDKVK hydratase K38(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATIANMCPEYGATAAFFPVDEVSIAYL Cytoplasmic aconitate C7(Carbamidomethyl); P28271 1 4313.287 3.07 LQTGREEDKVK hydratase K36(HeavyDimethyl); K38(HeavyDimethyl) Isoform 2 of Probable phospholipid- N-Term(Dimethyl); ATIECEQPQPDLYR Q9QZW0-2 8 1747.827 3.82 transporting ATPase C5(Carbamidomethyl) 11C Isoform 2 of Probable phospholipid- N-Term(Dimethyl:2H(6)13C(2)); ATIECEQPQPDLYR Q9QZW0-2 6 1755.867 3.92 transporting ATPase C5(Carbamidomethyl) 11C Oxysterol-binding ATKQLFSALTDPSVVIMADSLKIR D3YWU9 protein-related protein 5 K3(Dimethyl); K22(Dimethyl) 1 2660.483 2.78 (Fragment) L-threonine 3- ATLEVMEAPAERLSMRTYNISAMSFTP Q8K3F7 dehydrogenase, M15(Oxidation) 2 3942.975 2.94 EELAQALR mitochondrial N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); ATMDAGKLVSDEMVVELIEKNLETPS Isoform 2 of Adenylate Q9WTP6-2 K20(HeavyDimethyl); 1 3251.829 3.12 CK kinase 2, mitochondrial C27(Carbamidomethyl); K28(HeavyDimethyl) Prolactin regulatory N-Term(Dimethyl); ATMNLALAGDILAAGQDAQCQLLR D3Z3S1 element binding, isoform 2 2542.322 3.19 C20(Carbamidomethyl) CRA_b Prolactin regulatory N-Term(Dimethyl:2H(6)13C(2)); ATMNLALAGDILAAGQDAQCQLLR D3Z3S1 element binding, isoform 2 2550.362 3.08 C20(Carbamidomethyl) CRA_b ATTEDRNTALETLHQNSITQVSIYEVD Actin-related protein 2/3 N-Term(Dimethyl); K28(Dimethyl); Q9R0Q6 1 3791.855 3.67 KQDCR complex subunit 1A C31(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ATTEDRNTALETLHQNSITQVSIYEVD Actin-related protein 2/3 Q9R0Q6 K28(HeavyDimethyl); 1 3807.955 3.11 KQDCR complex subunit 1A C31(Carbamidomethyl) Transmembrane protein ATVGCFLLGGLGEALLVFSERR Q3UME2 C5(Carbamidomethyl) 2 2365.282 2.86 241 N-Term(Dimethyl:2H(6)13C(2)); Leucine-rich repeat- ATVLDLSCNK Q922Q8 C8(Carbamidomethyl); 1 1192.713 2.15 containing protein 59 K10(HeavyDimethyl)

N-Term(Dimethyl); Leucine-rich repeat- ATVLDLSCNKLSTLPSDFCGLTHLVK Q922Q8 C8(Carbamidomethyl); K10(Dimethyl); 1 2973.578 3.05 containing protein 59 C19(Carbamidomethyl); K26(Dimethyl)

40S ribosomal protein K5(Dimethyl); C7(Carbamidomethyl); ATYDKLCKEVPNYK P62852 1 1812.957 2.37 S25 K8(Dimethyl); K14(Dimethyl) N-Term(Dimethyl); AVAAGNSCRQEDVIATANLSR P26039 Talin-1 2 2231.119 2.45 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AVAAGNSCRQEDVIATANLSR Q71LX4 Talin-2 3 2239.166 3.78 C8(Carbamidomethyl) 26S protease regulatory N-Term(Dimethyl); AVASQLDCNFLK P62334 1 1421.743 2.46 subunit 10B C8(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 26S protease regulatory AVASQLDCNFLK P62334 C8(Carbamidomethyl); 1 1437.835 2.31 subunit 10B K12(HeavyDimethyl) N-Term(Dimethyl); AVASQLDCNFLKVVSSSIVDKYIGESA 26S protease regulatory P62334 C8(Carbamidomethyl); K12(Dimethyl); 1 3140.665 2.66 R subunit 10B K21(Dimethyl) N-Term(Dimethyl); AVATLQGEGLSVTGIVCHVGKAEDRE Dehydrogenase/reductas Q99LB2 C17(Carbamidomethyl); K21(Dimethyl); 1 2908.543 3.53 K e SDR family member 4 K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AVATLQGEGLSVTGIVCHVGKAEDRE Dehydrogenase/reductas C17(Carbamidomethyl); Q99LB2 1 2932.702 2.54 K e SDR family member 4 K21(HeavyDimethyl); K27(HeavyDimethyl) Lanosterol 14-alpha N-Term(Dimethyl); AVCGEDLPPLTYDQLKDLNLLDR Q8K0C4 1 2714.408 2.93 demethylase C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl); AVCMLSNTTAIAEAWAR P05214 Tubulin alpha-3 chain 11 1892.938 6.29 C3(Carbamidomethyl) N-Term(Dimethyl); AVCMLSNTTAIAEAWAR P05214 Tubulin alpha-3 chain 1 1908.933 4.03 C3(Carbamidomethyl); M4(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); AVCMLSNTTAIAEAWAR P05214 Tubulin alpha-3 chain 4 1900.975 5.40 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AVCMLSNTTAIAEAWAR P05214 Tubulin alpha-3 chain 2 1916.973 3.97 C3(Carbamidomethyl); M4(Oxidation) N-Term(Dimethyl); Superoxide dismutase AVCVLKGDGPVQGTIHFEQK P08228 C3(Carbamidomethyl); K6(Dimethyl); 11 2267.215 5.83 [Cu-Zn] K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Superoxide dismutase C3(Carbamidomethyl); AVCVLKGDGPVQGTIHFEQK P08228 7 2291.350 5.92 [Cu-Zn] K6(HeavyDimethyl); K20(HeavyDimethyl) Ankyrin repeat and N-Term(Dimethyl:2H(6)13C(2)); AVDENNESTACFLIR Q810B6 FYVE domain- 1 1774.880 2.39 C11(Carbamidomethyl) containing protein 1 N-Term(Dimethyl); K6(Dimethyl); C21(Carbamidomethyl); AVDNEKEGVQYSYSFFHLMLCCASLYI Q9QZI9 Serine incorporator 3 C22(Carbamidomethyl); 1 4872.252 3.46 MMTITSWYSPDAK M28(Oxidation); M29(Oxidation); K40(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AVEGDEQWILAEVVSYSHATNKYEVD SAGA-associated factor Q9DA08 K22(HeavyDimethyl); 1 4132.159 3.62 DIDEEGKER 29 homolog K33(HeavyDimethyl) Isoform 2 of Protein N-Term(Dimethyl:2H(6)13C(2)); AVFHQLANLPTDPPSIHK Q8R1F6-2 1 2057.185 2.96 HID1 K18(HeavyDimethyl) N-Term(Dimethyl); 60S ribosomal protein AVGIWHCGSCMK P61514 C7(Carbamidomethyl); 2 1461.675 2.62 L37a C10(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); 60S ribosomal protein C7(Carbamidomethyl); AVGIWHCGSCMK P61514 1 1477.674 2.29 L37a C10(Carbamidomethyl); M11(Oxidation); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein C7(Carbamidomethyl); AVGIWHCGSCMK P61514 3 1477.766 2.38 L37a C10(Carbamidomethyl); K12(HeavyDimethyl) N-Term(Dimethyl); AVIFCLSADKK Q9R0P5 Destrin C5(Carbamidomethyl); K10(Dimethyl); 5 1335.770 2.46 K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); AVIFCLSADKK Q9R0P5 Destrin 1 1359.899 2.28 K10(HeavyDimethyl); K11(HeavyDimethyl) Isobutyryl-CoA N-Term(Dimethyl); AVIFEDCAVPVANR Q9D7B6 dehydrogenase, 11 1588.810 4.14 C7(Carbamidomethyl) mitochondrial Isobutyryl-CoA N-Term(Dimethyl:2H(6)13C(2)); AVIFEDCAVPVANR Q9D7B6 dehydrogenase, 10 1596.855 3.67 C7(Carbamidomethyl) mitochondrial Adenylate kinase 4, N-Term(Dimethyl); K11(Dimethyl); AVILGPPGSGKGTVCER A2ARF6 mitochondrial 2 1753.972 3.03 C15(Carbamidomethyl) (Fragment) Adenylate kinase 4, N-Term(Dimethyl:2H(6)13C(2)); AVILGPPGSGKGTVCER A2ARF6 mitochondrial K11(HeavyDimethyl); 1 1770.042 2.72 (Fragment) C15(Carbamidomethyl) AVKNAIDDGCVVPGAGAVEVALAEAL T-complex protein 1 N-Term(Dimethyl); K3(Dimethyl); P80317 5 2834.594 4.40 IK subunit zeta C10(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AVKNAIDDGCVVPGAGAVEVALAEAL T-complex protein 1 K3(HeavyDimethyl); P80317 2 2858.687 3.56 IK subunit zeta C10(Carbamidomethyl); K28(HeavyDimethyl) Cell division control N-Term(Dimethyl); K3(Dimethyl); AVKYVECSALTQK P60766 1 1580.872 2.12 protein 42 homolog C7(Carbamidomethyl); K13(Dimethyl) Isoform 1 of Cell N-Term(Dimethyl); K3(Dimethyl); AVKYVECSALTQR P60766-1 division control protein 1 1580.869 2.10 C7(Carbamidomethyl) 42 homolog Zinc finger and BTB N-Term(Dimethyl:2H(6)13C(2)); AVLAACSSYFRMFFMNHQHSTAQLNL Q91VL9 domain-containing C6(Carbamidomethyl); M15(Oxidation); 1 3608.782 2.78 SNMK protein 1 M29(Oxidation); K30(HeavyDimethyl) Trans-1,2- N-Term(Dimethyl); AVLCEKPMGVNAAEVR Q9DBB8 dihydrobenzene-1,2-diol 3 1799.943 3.42 C4(Carbamidomethyl); K6(Dimethyl) dehydrogenase Trans-1,2- N-Term(Dimethyl:2H(6)13C(2)); AVLCEKPMGVNAAEVR Q9DBB8 dihydrobenzene-1,2-diol C4(Carbamidomethyl); 2 1816.038 2.19 dehydrogenase K6(HeavyDimethyl) Serine N-Term(Dimethyl); AVLEALGSCLNNKYSEGYPGQR G3UZ26 hydroxymethyltransferas 1 2482.246 4.85 C9(Carbamidomethyl); K13(Dimethyl) e (Fragment) Serine N-Term(Dimethyl:2H(6)13C(2)); AVLEALGSCLNNKYSEGYPGQR G3UZ26 hydroxymethyltransferas C9(Carbamidomethyl); 7 2498.329 5.52 e (Fragment) K13(HeavyDimethyl) N-Term(Dimethyl); AVLFCLSDDKR P45591 Cofilin-2 2 1379.738 2.19 C5(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AVLFCLSDDKR P45591 Cofilin-2 C5(Carbamidomethyl); 1 1395.824 2.43 K10(HeavyDimethyl) N-Term(Dimethyl); AVLFCLSEDKK P18760 Cofilin-1 C5(Carbamidomethyl); K10(Dimethyl); 1 1393.768 2.37 K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); AVLFCLSEDKK P18760 Cofilin-1 1 1417.901 2.21 K10(HeavyDimethyl); K11(HeavyDimethyl) N-Term(Dimethyl); K11(Dimethyl); AVLLGPPGAGKGTQAPKLAENFCVCH Isoform 2 of Adenylate Q9WTP6-2 K17(Dimethyl); C23(Carbamidomethyl); 1 3633.922 3.07 LATGDMLR kinase 2, mitochondrial C25(Carbamidomethyl) Protein transport protein N-Term(Dimethyl:2H(6)13C(2)); AVLNPLCQVDYR E9Q1S3 5 1483.813 2.37 Sec23A C7(Carbamidomethyl) Fructose-bisphosphate N-Term(Dimethyl); AVLRIADQCPSSLAIQENANALAR Q91Y97 1 2609.373 3.25 aldolase B C9(Carbamidomethyl)

Fructose-bisphosphate N-Term(Dimethyl:2H(6)13C(2)); AVLRIADQCPSSLAIQENANALAR Q91Y97 4 2617.424 4.06 aldolase B C9(Carbamidomethyl)

N-Term(Dimethyl); AVLTSQETLFGGSDCTGNFCLFK Q921I1 Serotransferrin C15(Carbamidomethyl); 2 2608.250 4.15 C20(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C15(Carbamidomethyl); AVLTSQETLFGGSDCTGNFCLFK Q921I1 Serotransferrin 2 2624.341 4.54 C20(Carbamidomethyl); K23(HeavyDimethyl) N-Term(Dimethyl); Epidermal growth factor C6(Carbamidomethyl); AVNHVCNPLCSSEGCWGPEPR Q9WVF5 2 2454.072 3.14 receptor C10(Carbamidomethyl); C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Epidermal growth factor C6(Carbamidomethyl); AVNHVCNPLCSSEGCWGPEPR Q9WVF5 3 2462.111 3.13 receptor C10(Carbamidomethyl); C15(Carbamidomethyl) Carbamoyl-phosphate AVNTLNEALEFANSVGYPCLLRPSYVL N-Term(Dimethyl); Q8C196 synthase [ammonia], 1 4834.411 4.60 SGSAMNVVFSEDEMKR C19(Carbamidomethyl); K42(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); AVNTLNEALEFANSVGYPCLLRPSYVL Q8C196 synthase [ammonia], C19(Carbamidomethyl); 1 4850.506 4.59 SGSAMNVVFSEDEMKR mitochondrial K42(HeavyDimethyl) NADPH:adrenodoxin N-Term(Dimethyl); AVPTGDVEDLPCGLLLSSVGYK Q61578 oxidoreductase, 1 2346.231 3.43 C12(Carbamidomethyl); K22(Dimethyl) mitochondrial Cytosolic 10- N-Term(Dimethyl); K13(Dimethyl); AVQMGMSSVFFNKGENCIAAGR Q8R0Y6 formyltetrahydrofolate 2 2430.174 4.75 C17(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); AVQMGMSSVFFNKGENCIAAGR Q8R0Y6 formyltetrahydrofolate K13(HeavyDimethyl); 1 2446.259 4.48 dehydrogenase C17(Carbamidomethyl) N-Term(Dimethyl); AVQNACQILMK G3X982 Aldehyde oxidase 3 7 1331.713 2.99 C6(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AVQNACQILMK G3X982 Aldehyde oxidase 3 C6(Carbamidomethyl); 3 1347.806 2.41 K11(HeavyDimethyl) Probable JmjC domain- C9(Carbamidomethyl); containing histone AVRGVREMCDACEATLFNVHWVCR Q69ZK6 C12(Carbamidomethyl); 2 2936.380 2.85 demethylation protein C23(Carbamidomethyl) 2C N-Term(Dimethyl:2H(6)13C(2)); M13(Oxidation); AVSFLAYEDPLGMALGCMALFLSALM L7N217 Protein Vmn2r12 C17(Carbamidomethyl); 1 4221.341 3.01 VLVLVTFVKYK M18(Oxidation); K35(HeavyDimethyl); K37(HeavyDimethyl)

AVSLSMGLYMGETETKVMGNDLGYP Glucocorticoid receptor M10(Oxidation); K16(HeavyDimethyl); E9Q8A6 1 3342.654 3.42 QQGQLG (Fragment) M18(Oxidation)

N-Term(Dimethyl); AVSSFFSGSCVPCADPVAFPK Q921I1 Serotransferrin C10(Carbamidomethyl); 4 2286.093 5.37 C13(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); AVSSFFSGSCVPCADPVAFPK Q921I1 Serotransferrin 4 2302.179 5.23 C13(Carbamidomethyl); K21(HeavyDimethyl) NADH-ubiquinone N-Term(Dimethyl); AVTEGAQAVEEPSIC Q91VD9 oxidoreductase 75 kDa 1 1588.747 2.29 C15(Carbamidomethyl) subunit, mitochondrial NADH-ubiquinone N-Term(Dimethyl:2H(6)13C(2)); AVTEGAQAVEEPSIC Q91VD9 oxidoreductase 75 kDa 2 1596.791 2.39 C15(Carbamidomethyl) subunit, mitochondrial AVVSQRLTESPCALVASQYGWSGNME N-Term(Dimethyl); F7C312 Endoplasmin (Fragment) 2 3024.490 4.19 R C12(Carbamidomethyl) AVVSQRLTESPCALVASQYGWSGNME N-Term(Dimethyl:2H(6)13C(2)); F7C312 Endoplasmin (Fragment) 2 3032.511 3.83 R C12(Carbamidomethyl) N-Term(Dimethyl); Heterogeneous nuclear AVVVCPKDEDYKQR G3XA10 C5(Carbamidomethyl); K7(Dimethyl); 1 1790.945 2.59 ribonucleoprotein U K12(Dimethyl) Dimethylglycine N-Term(Dimethyl); AWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, 15 2587.190 5.88 C8(Carbamidomethyl); K22(Dimethyl) mitochondrial Dimethylglycine N-Term(Dimethyl); M6(Oxidation); AWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, 1 2603.199 3.02 C8(Carbamidomethyl); K22(Dimethyl) mitochondrial Dimethylglycine N-Term(Dimethyl:2H(6)13C(2)); AWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, C8(Carbamidomethyl); 5 2603.288 4.82 mitochondrial K22(HeavyDimethyl) Dimethylglycine N-Term(Dimethyl:2H(6)13C(2)); AWGSEMNCDTNPLEAGLEYFVK Q9DBT9 dehydrogenase, M6(Oxidation); C8(Carbamidomethyl); 1 2619.294 2.57 mitochondrial K22(HeavyDimethyl)

Dimethylglycine N-Term(Dimethyl); AWGSEMNCDTNPLEAGLEYFVKLNKP Q9DBT9 dehydrogenase, C8(Carbamidomethyl); K22(Dimethyl); 8 3726.846 4.96 ADFIGK mitochondrial K25(Dimethyl); K32(Dimethyl)

Dimethylglycine N-Term(Dimethyl); M6(Oxidation); AWGSEMNCDTNPLEAGLEYFVKLNKP Q9DBT9 dehydrogenase, C8(Carbamidomethyl); K22(Dimethyl); 1 3742.864 3.19 ADFIGK mitochondrial K25(Dimethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dimethylglycine C8(Carbamidomethyl); AWGSEMNCDTNPLEAGLEYFVKLNKP Q9DBT9 dehydrogenase, K22(HeavyDimethyl); 8 3759.044 4.81 ADFIGK mitochondrial K25(HeavyDimethyl); K32(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NADPH--cytochrome AWLREQGKEVGETLLYYGCR P37040 K8(HeavyDimethyl); 1 2500.356 3.37 P450 reductase C19(Carbamidomethyl) Transmembrane protein K6(Dimethyl); M16(Oxidation); AWMGIKENAGHRLNAMFEVNTDLQK O70472 1 2945.514 2.28 131 K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AWNWHLDPELWARSVRQQLNTCLHFI D3Z2X2 Protein Dnhd1 C22(Carbamidomethyl); 1 3862.039 3.09 LEEK K30(HeavyDimethyl) S-formylglutathione N-Term(Dimethyl); AYDATCLVK H3BJP2 8 1096.569 2.66 hydrolase (Fragment) C6(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); S-formylglutathione AYDATCLVK H3BJP2 C6(Carbamidomethyl); 3 1112.657 2.34 hydrolase (Fragment) K9(HeavyDimethyl) Isoform 2 of Rab GDP N-Term(Dimethyl); AYDATTHFETTCDDIKDIYKR Q61598-2 dissociation inhibitor C12(Carbamidomethyl); K16(Dimethyl); 2 2647.264 3.17 beta K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Rab GDP C12(Carbamidomethyl); AYDATTHFETTCDDIKDIYKR Q61598-2 dissociation inhibitor 2 2671.393 3.30 K16(HeavyDimethyl); beta K20(HeavyDimethyl) AYEIICQTMQENSGLVVTLPHEVADEQ Q8VC12 Urocanate hydratase C6(Carbamidomethyl); M9(Oxidation) 1 3995.926 2.83 VLQQALRP AYEIICQTMQENSGLVVTLPHEVADEQ N-Term(Dimethyl:2H(6)13C(2)); Q8VC12 Urocanate hydratase 1 4016.073 4.72 VLQQALRP C6(Carbamidomethyl) N-Term(Dimethyl); AYHEQLSVAEITNACFEPANQMVK P05214 Tubulin alpha-3 chain 1 2806.354 3.02 C15(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AYHEQLSVAEITNACFEPANQMVK P05214 Tubulin alpha-3 chain C15(Carbamidomethyl); 1 2822.472 2.79 K24(HeavyDimethyl) Zinc-alpha-2- N-Term(Dimethyl); AYLEEECPEMLKR Q64726 1 1723.861 2.31 glycoprotein C7(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); M4(Oxidation); Intron-binding protein AYLMSICCMVNEKFR A2AQA7 C7(Carbamidomethyl); 1 1993.945 2.61 aquarius C8(Carbamidomethyl); K13(Dimethyl) Betaine--homocysteine S-N-Term(Dimethyl); AYLMSQPLAYHTPDCGK O35490 24 2007.959 4.71 methyltransferase 1 C15(Carbamidomethyl); K17(Dimethyl)

Betaine--homocysteine S-N-Term(Dimethyl); M4(Oxidation); AYLMSQPLAYHTPDCGK O35490 14 2023.957 3.58 methyltransferase 1 C15(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- AYLMSQPLAYHTPDCGK O35490 C15(Carbamidomethyl); 28 2024.047 5.68 methyltransferase 1 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- AYLMSQPLAYHTPDCGK O35490 M4(Oxidation); C15(Carbamidomethyl); 10 2040.044 4.39 methyltransferase 1 K17(HeavyDimethyl) AYLMSQPLAYHTPDCGKQGFIDLPEFP Betaine--homocysteine S-M4(Oxidation); C15(Carbamidomethyl); O35490 1 3838.879 3.44 FGLEPR methyltransferase 1 K17(Dimethyl)

AYLMSQPLAYHTPDCGKQGFIDLPEFP Betaine--homocysteine S-N-Term(Dimethyl); O35490 35 3850.900 7.59 FGLEPR methyltransferase 1 C15(Carbamidomethyl); K17(Dimethyl)

AYLMSQPLAYHTPDCGKQGFIDLPEFP Betaine--homocysteine S-N-Term(Dimethyl); M4(Oxidation); O35490 14 3866.889 6.28 FGLEPR methyltransferase 1 C15(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AYLMSQPLAYHTPDCGKQGFIDLPEFP Betaine--homocysteine S- O35490 C15(Carbamidomethyl); 37 3866.970 8.31 FGLEPR methyltransferase 1 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AYLMSQPLAYHTPDCGKQGFIDLPEFP Betaine--homocysteine S- O35490 M4(Oxidation); C15(Carbamidomethyl); 26 3882.972 8.05 FGLEPR methyltransferase 1 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AYLQALSVLRDLAIGGELTDYTYYAV Q9JLC8-2 Isoform 2 of Sacsin C41(Carbamidomethyl); 1 4874.579 3.16 WPDPDLVHDDFSVICK K42(HeavyDimethyl) N-Term(Dimethyl); AYPIDQYPCR Q8VC12 Urocanate hydratase 2 1310.621 2.57 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AYPIDQYPCR Q8VC12 Urocanate hydratase 2 1318.659 2.26 C9(Carbamidomethyl) N-Term(Dimethyl); K9(Dimethyl); AYPPTSMSKSPPTVLVICGPGNNGGDG NAD(P)H-hydrate Q8K4Z3 C18(Carbamidomethyl); 1 3328.640 3.10 LVCAR epimerase C30(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); AYPPTSMSKSPPTVLVICGPGNNGGDG NAD(P)H-hydrate K9(HeavyDimethyl); Q8K4Z3 1 3344.746 3.07 LVCAR epimerase C18(Carbamidomethyl); C30(Carbamidomethyl) AYSGSQIDILIDQGKDDEFLSNGQLLPD S-formylglutathione N-Term(Dimethyl); K15(Dimethyl); H3BJP2 2 4170.083 4.62 NFIAACTEK hydrolase (Fragment) C34(Carbamidomethyl); K37(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); AYSGSQIDILIDQGKDDEFLSNGQLLPD S-formylglutathione K15(HeavyDimethyl); H3BJP2 1 4194.221 5.77 NFIAACTEK hydrolase (Fragment) C34(Carbamidomethyl); K37(HeavyDimethyl) N-Term(Dimethyl); Isoform Short of CAEENCFMQQSQEK P01027-2 C1(Carbamidomethyl); 1 1844.749 3.06 Complement C3 C6(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine--tRNA CAEIFVGGQSIGK Q9WUA2 C1(Carbamidomethyl); 2 1437.834 2.42 ligase beta subunit K13(HeavyDimethyl) N-Term(Dimethyl); CAFMGSLAPGHVADFLVADFR P97328 Ketohexokinase 14 2309.115 5.50 C1(Carbamidomethyl) N-Term(Dimethyl); CAFMGSLAPGHVADFLVADFR P97328 Ketohexokinase 3 2325.102 3.42 C1(Carbamidomethyl); M4(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); CAFMGSLAPGHVADFLVADFR P97328 Ketohexokinase 10 2317.171 5.32 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CAFMGSLAPGHVADFLVADFR P97328 Ketohexokinase 4 2333.162 4.30 C1(Carbamidomethyl); M4(Oxidation) N-Term(Dimethyl); CAFMGSLAPGHVADFLVADFRQR P97328 Ketohexokinase 10 2593.284 3.92 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CAFMGSLAPGHVADFLVADFRQR P97328 Ketohexokinase 9 2601.324 4.03 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CAFMGSLAPGHVADFLVADFRQR P97328 Ketohexokinase 1 2617.326 3.05 C1(Carbamidomethyl); M4(Oxidation) Argininosuccinate lyase N-Term(Dimethyl); CAGLLMTLK F7D439 1 1062.603 2.29 (Fragment) C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Argininosuccinate lyase CAGLLMTLK F7D439 C1(Carbamidomethyl); 3 1078.696 2.23 (Fragment) K9(HeavyDimethyl) N-Term(Dimethyl); CAINRLHQELGAK F8VPN4 Protein Agl 1 1565.858 2.98 C1(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CAINRLHQELGAK F8VPN4 Protein Agl C1(Carbamidomethyl); 2 1581.943 2.46 K13(HeavyDimethyl) N-Term(Dimethyl); CAKAEAGEGQKPSPAQLELR Q8K183 Pyridoxal kinase C1(Carbamidomethyl); K3(Dimethyl); 3 2224.169 2.92 K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CAKAEAGEGQKPSPAQLELR Q8K183 Pyridoxal kinase 3 2248.305 3.05 K3(HeavyDimethyl); K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CALSSVDIYRTPLYDLR Q91VH6 Protein MEMO1 1 2078.122 2.41 C1(Carbamidomethyl) N-Term(Dimethyl); CAPNNKEEYNGYTGAFR Q921I1 Serotransferrin 15 2046.929 4.63 C1(Carbamidomethyl); K6(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CAPNNKEEYNGYTGAFR Q921I1 Serotransferrin C1(Carbamidomethyl); 8 2063.014 4.37 K6(HeavyDimethyl) A-kinase anchor protein N-Term(Dimethyl:2H(6)13C(2)); CASAGLAAAARAPAVPRAPGPR H3BJV2 7 isoform alpha 1 2124.188 2.65 C1(Carbamidomethyl) (Fragment)

Isocitrate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); CATITPDEAR P54071 2 1169.599 2.11 [NADP], mitochondrial C1(Carbamidomethyl)

N-Term(Dimethyl); Isocitrate dehydrogenase CATITPDEARVEEFKLK D6RIL6 C1(Carbamidomethyl); K15(Dimethyl); 1 2091.108 2.55 [NADP], mitochondrial K17(Dimethyl)

Isocitrate dehydrogenase N-Term(Dimethyl); CATITPDEK O88844 2 1090.546 2.56 [NADP] cytoplasmic C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase CATITPDEK O88844 C1(Carbamidomethyl); 2 1106.633 2.31 [NADP] cytoplasmic K9(HeavyDimethyl) Isocitrate dehydrogenase N-Term(Dimethyl); CATITPDEKR O88844 3 1246.644 2.61 [NADP] cytoplasmic C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase CATITPDEKR O88844 C1(Carbamidomethyl); 3 1262.731 3.00 [NADP] cytoplasmic K9(HeavyDimethyl) N-Term(Dimethyl); Isocitrate dehydrogenase CATITPDEKRVEEFK O88844 C1(Carbamidomethyl); K9(Dimethyl); 2 1906.987 2.65 [NADP] cytoplasmic K15(Dimethyl) Glutamate N-Term(Dimethyl); CAVVDVPFGGAK P26443 dehydrogenase 1, 16 1275.674 3.35 C1(Carbamidomethyl); K12(Dimethyl) mitochondrial Glutamate N-Term(Dimethyl:2H(6)13C(2)); CAVVDVPFGGAK P26443 dehydrogenase 1, C1(Carbamidomethyl); 16 1291.760 3.76 mitochondrial K12(HeavyDimethyl) Glutamate N-Term(Dimethyl); CAVVDVPFGGAKAGVK P26443 dehydrogenase 1, C1(Carbamidomethyl); K12(Dimethyl); 14 1658.925 3.99 mitochondrial K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate C1(Carbamidomethyl); CAVVDVPFGGAKAGVK P26443 dehydrogenase 1, 15 1683.057 4.16 K12(HeavyDimethyl); mitochondrial K16(HeavyDimethyl) N-Term(Dimethyl); C1(Carbamidomethyl); CCAEANPPACYGTVLAEFQPLVEEPK P07724 Serum albumin 3 3006.413 4.96 C2(Carbamidomethyl); C10(Carbamidomethyl); K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CCAEANPPACYGTVLAEFQPLVEEPK P07724 Serum albumin C2(Carbamidomethyl); 2 3022.500 3.14 C10(Carbamidomethyl); K26(HeavyDimethyl) N-Term(Dimethyl); C1(Carbamidomethyl); CCAEANPPACYGTVLAEFQPLVEEPKN P07724 Serum albumin C2(Carbamidomethyl); 3 3488.736 3.98 LVK C10(Carbamidomethyl); K26(Dimethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CCAEANPPACYGTVLAEFQPLVEEPKN C2(Carbamidomethyl); P07724 Serum albumin 2 3512.872 3.74 LVK C10(Carbamidomethyl); K26(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl); Vitamin D-binding C1(Carbamidomethyl); CCESTSEDCMASELPEHTIK P21614 7 2440.010 3.99 protein C2(Carbamidomethyl); C9(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); Vitamin D-binding CCESTSEDCMASELPEHTIK P21614 C2(Carbamidomethyl); 7 2456.093 5.13 protein C9(Carbamidomethyl); K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CCLDLSNLSSGEMSASPLTTSADLEDN M-phase inducer C1(Carbamidomethyl); P48967 1 4571.269 3.14 GSLDSSGPLDRQLTGK phosphatase 3 C2(Carbamidomethyl); K43(HeavyDimethyl) N-Term(Dimethyl); Dimethylaniline C1(Carbamidomethyl); CCLEEGLEPTCFEK G3X946 monooxygenase [N- 1 1827.772 3.17 C2(Carbamidomethyl); oxide-forming] C11(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl); Dimethylaniline C1(Carbamidomethyl); CCLEEGLEPTCFER Q8C9C1 monooxygenase [N- 2 1827.764 2.42 C2(Carbamidomethyl); oxide-forming] 1 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Dimethylaniline C1(Carbamidomethyl); CCLEEGLEPTCFER Q8C9C1 monooxygenase [N- 7 1835.816 3.87 C2(Carbamidomethyl); oxide-forming] 1 C11(Carbamidomethyl) N-Term(Dimethyl); Dimethylaniline C1(Carbamidomethyl); CCLEEGLEPVCFER P97872 monooxygenase [N- 9 1825.789 4.16 C2(Carbamidomethyl); oxide-forming] 5 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Dimethylaniline C1(Carbamidomethyl); CCLEEGLEPVCFER P97872 monooxygenase [N- 9 1833.828 4.67 C2(Carbamidomethyl); oxide-forming] 5 C11(Carbamidomethyl) N-Term(Dimethyl); CCSGSLVER P07724 Serum albumin C1(Carbamidomethyl); 6 1095.488 2.58 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CCSGSLVER P07724 Serum albumin C1(Carbamidomethyl); 4 1103.531 2.55 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CCTLPEDQR P07724 Serum albumin C1(Carbamidomethyl); 2 1214.565 2.52 C2(Carbamidomethyl) N-Term(Dimethyl); Prolow-density C1(Carbamidomethyl); CDADADCMDGSDEEACGTGVR Q91ZX7 lipoprotein receptor- 1 2318.833 3.39 C7(Carbamidomethyl); related protein 1 C16(Carbamidomethyl) Electron transfer N-Term(Dimethyl); CDEKVKVFSVR Q99LC5 flavoprotein subunit C1(Carbamidomethyl); K4(Dimethyl); 5 1450.803 3.03 alpha, mitochondrial K6(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Electron transfer C1(Carbamidomethyl); CDEKVKVFSVR Q99LC5 flavoprotein subunit 3 1474.941 2.14 K4(HeavyDimethyl); alpha, mitochondrial K6(HeavyDimethyl) N-Term(Dimethyl); Prolow-density C1(Carbamidomethyl); CDGEDDCGDNSDENPEECAR Q91ZX7 lipoprotein receptor- 1 2371.808 3.27 C7(Carbamidomethyl); related protein 1 C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Electron transfer C1(Carbamidomethyl); CDKVVQDLCK Q99LC5 flavoprotein subunit K3(HeavyDimethyl); 1 1372.824 2.22 alpha, mitochondrial C9(Carbamidomethyl); K10(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); Electron transfer K3(HeavyDimethyl); CDKVVQDLCKVAGVAK Q99LC5 flavoprotein subunit 1 1934.231 3.18 C9(Carbamidomethyl); alpha, mitochondrial K10(HeavyDimethyl); K16(HeavyDimethyl) CDVDIRKDLYANTVLSGGTTMYPGIA N-Term(Dimethyl); E9Q1F2 Actin, cytoplasmic 1 10 3157.570 6.12 DR C1(Carbamidomethyl); K7(Dimethyl) N-Term(Dimethyl); CDVDIRKDLYANTVLSGGTTMYPGIA E9Q1F2 Actin, cytoplasmic 1 C1(Carbamidomethyl); K7(Dimethyl); 4 3173.554 4.23 DR M21(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); CDVDIRKDLYANTVLSGGTTMYPGIA E9Q1F2 Actin, cytoplasmic 1 C1(Carbamidomethyl); 8 3173.664 6.15 DR K7(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CDVDIRKDLYANTVLSGGTTMYPGIA E9Q1F2 Actin, cytoplasmic 1 C1(Carbamidomethyl); 2 3189.653 4.61 DR K7(HeavyDimethyl); M21(Oxidation) 2,4-dienoyl-CoA N-Term(Dimethyl); CDVRDPDMVHNTVLELIK Q9CQ62 6 2210.136 3.66 reductase, mitochondrial C1(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 2,4-dienoyl-CoA CDVRDPDMVHNTVLELIK Q9CQ62 C1(Carbamidomethyl); 5 2226.217 4.24 reductase, mitochondrial K18(HeavyDimethyl) NADH dehydrogenase [ubiquinone] 1 alpha N-Term(Dimethyl); CDVYDIMHLR Q9DC69 1 1349.635 2.53 subcomplex subunit 9, C1(Carbamidomethyl) mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha N-Term(Dimethyl:2H(6)13C(2)); CDVYDIMHLR Q9DC69 1 1357.677 2.79 subcomplex subunit 9, C1(Carbamidomethyl) mitochondrial

N-Term(Dimethyl); CEAFGWHTIIVDGHSVEELCK P40142 Transketolase C1(Carbamidomethyl); 2 2543.208 3.99 C20(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CEAFGWHTIIVDGHSVEELCK P40142 Transketolase 4 2559.289 3.91 C20(Carbamidomethyl); K21(HeavyDimethyl) Cystathionine beta- N-Term(Dimethyl); CEFFNAGGSVKDR Q91WT9 5 1542.740 2.46 synthase C1(Carbamidomethyl); K11(Dimethyl) Dihydropyrimidine N-Term(Dimethyl); CEFLPFLSPR Q8CHR6 dehydrogenase 1 1293.667 2.43 C1(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); CEFLPFLSPR Q8CHR6 dehydrogenase 4 1301.714 2.46 C1(Carbamidomethyl) [NADP(+)] 60 kDa heat shock N-Term(Dimethyl); CEFQDAYVLLSEK P63038 4 1657.813 4.00 protein, mitochondrial C1(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60 kDa heat shock CEFQDAYVLLSEK P63038 C1(Carbamidomethyl); 8 1673.906 3.89 protein, mitochondrial K13(HeavyDimethyl) N-Term(Dimethyl); 60 kDa heat shock CEFQDAYVLLSEKK P63038 C1(Carbamidomethyl); K13(Dimethyl); 13 1813.935 3.90 protein, mitochondrial K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60 kDa heat shock C1(Carbamidomethyl); CEFQDAYVLLSEKK P63038 14 1838.061 4.42 protein, mitochondrial K13(HeavyDimethyl); K14(HeavyDimethyl) Isoform 2 of UTP-- N-Term(Dimethyl:2H(6)13C(2)); CEFVMEVTNK Q91ZJ5-2 glucose-1-phosphate C1(Carbamidomethyl); 2 1328.716 2.03 uridylyltransferase K10(HeavyDimethyl) Isoform 2 of UTP-- N-Term(Dimethyl); CEFVMEVTNKTR Q91ZJ5-2 glucose-1-phosphate 7 1569.772 2.45 C1(Carbamidomethyl); K10(Dimethyl) uridylyltransferase Isoform 2 of UTP-- N-Term(Dimethyl:2H(6)13C(2)); CEFVMEVTNKTR Q91ZJ5-2 glucose-1-phosphate C1(Carbamidomethyl); 3 1585.865 2.63 uridylyltransferase K10(HeavyDimethyl) N-Term(Dimethyl); CELLYEGPPDDEAAMGIK P58252 Elongation factor 2 8 2063.961 5.04 C1(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl); CELLYEGPPDDEAAMGIK P58252 Elongation factor 2 C1(Carbamidomethyl); M15(Oxidation); 3 2079.958 3.58 K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CELLYEGPPDDEAAMGIK P58252 Elongation factor 2 C1(Carbamidomethyl); 7 2080.058 5.65 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CELLYEGPPDDEAAMGIK P58252 Elongation factor 2 C1(Carbamidomethyl); M15(Oxidation); 3 2096.050 4.13 K18(HeavyDimethyl)

Carbamoyl-phosphate N-Term(Dimethyl); CEMASTGEVACFGEGIHTAFLK Q8C196 synthase [ammonia], C1(Carbamidomethyl); 19 2471.140 6.60 mitochondrial C11(Carbamidomethyl); K22(Dimethyl)

Carbamoyl-phosphate N-Term(Dimethyl); CEMASTGEVACFGEGIHTAFLK Q8C196 synthase [ammonia], C1(Carbamidomethyl); M3(Oxidation); 13 2487.131 6.29 mitochondrial C11(Carbamidomethyl); K22(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate C1(Carbamidomethyl); CEMASTGEVACFGEGIHTAFLK Q8C196 synthase [ammonia], 25 2487.223 7.90 C11(Carbamidomethyl); mitochondrial K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate C1(Carbamidomethyl); M3(Oxidation); CEMASTGEVACFGEGIHTAFLK Q8C196 synthase [ammonia], 10 2503.222 7.04 C11(Carbamidomethyl); mitochondrial K22(HeavyDimethyl) N-Term(Dimethyl); Carbamoyl-phosphate CEMASTGEVACFGEGIHTAFLKAMLST C1(Carbamidomethyl); Q8C196 synthase [ammonia], 1 3828.965 2.91 GFKIPQK C11(Carbamidomethyl); K22(Dimethyl); mitochondrial K30(Dimethyl); K34(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); Carbamoyl-phosphate CEMASTGEVACFGEGIHTAFLKAMLST C11(Carbamidomethyl); Q8C196 synthase [ammonia], 3 3861.105 3.27 GFKIPQK K22(HeavyDimethyl); mitochondrial K30(HeavyDimethyl); K34(HeavyDimethyl) C1(Carbamidomethyl); CENIITIENGIPCDPLDMKGGHINDGFL Q9ESG4 Collectrin C13(Carbamidomethyl); 1 3824.805 2.89 TEDER M18(Oxidation); K19(HeavyDimethyl) N-Term(Dimethyl); CESAPGCGVWQRPMIDNPNYK P35564 Calnexin C1(Carbamidomethyl); 1 2535.144 2.64 C7(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl); C1(Carbamidomethyl); CESAPGCGVWQRPMIDNPNYKGK P35564 Calnexin 2 2748.299 2.71 C7(Carbamidomethyl); K21(Dimethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CESAPGCGVWQRPMIDNPNYKGK P35564 Calnexin C7(Carbamidomethyl); 1 2772.433 3.08 K21(HeavyDimethyl); K23(HeavyDimethyl) C1(Carbamidomethyl); Cullin-associated C10(Carbamidomethyl); CESPEEGTRCVVAECIGK Q6ZQ73 NEDD8-dissociated 1 2116.974 2.40 C15(Carbamidomethyl); protein 2 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CEVCGKGFTKLSHLQAHER Q3UTF4 Protein Zfp114 C4(Carbamidomethyl); 1 2365.289 2.46 K6(HeavyDimethyl); K10(HeavyDimethyl) N-Term(Dimethyl); CEVNGEKAHPLFTFLR P11352 Glutathione peroxidase 1 2 1974.029 2.96 C1(Carbamidomethyl); K7(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CEVNGEKAHPLFTFLR P11352 Glutathione peroxidase 1 C1(Carbamidomethyl); 4 1990.110 2.98 K7(HeavyDimethyl) Phenazine biosynthesis- N-Term(Dimethyl); CFAPWVGVAEDPVTGSTHTLLGPYWS Q9CXN7 like domain-containing C1(Carbamidomethyl); K31(Dimethyl); 5 3615.813 4.32 EELGKK protein 2 K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenazine biosynthesis- CFAPWVGVAEDPVTGSTHTLLGPYWS C1(Carbamidomethyl); Q9CXN7 like domain-containing 9 3639.952 3.82 EELGKK K31(HeavyDimethyl); protein 2 K32(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CFATQVYCK D3Z4U1 Uricase 22 1248.665 3.58 C8(Carbamidomethyl); K9(HeavyDimethyl) N-Term(Dimethyl); S-formylglutathione CFGGLQKVFEHSSVELK H3BJP2 C1(Carbamidomethyl); K7(Dimethyl); 2 2049.088 3.16 hydrolase (Fragment) K17(Dimethyl) Transmembrane emp24 N-Term(Dimethyl); CFIEEIPDETMVIGNYR Q8R1V4 domain-containing 6 2113.994 4.46 C1(Carbamidomethyl) protein 4 Transmembrane emp24 N-Term(Dimethyl:2H(6)13C(2)); CFIEEIPDETMVIGNYR Q8R1V4 domain-containing 3 2122.043 4.81 C1(Carbamidomethyl) protein 4 Transmembrane emp24 N-Term(Dimethyl:2H(6)13C(2)); CFIEEIPDETMVIGNYR Q8R1V4 domain-containing 2 2138.062 2.50 C1(Carbamidomethyl); M11(Oxidation) protein 4 N-Term(Dimethyl); CFIVGADNVGSK E9Q070 Uncharacterized protein 4 1322.673 2.34 C1(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CFIVGADNVGSK E9Q070 Uncharacterized protein C1(Carbamidomethyl); 11 1338.761 2.78 K12(HeavyDimethyl) CFSIDNPGYEPEVVAVHPGGDTVAVG WD repeat-containing N-Term(Dimethyl); O88342 1 3413.604 4.08 GTDGNVR protein 1 C1(Carbamidomethyl) CFSIDNPGYEPEVVAVHPGGDTVAVG WD repeat-containing N-Term(Dimethyl:2H(6)13C(2)); O88342 1 3421.655 4.12 GTDGNVR protein 1 C1(Carbamidomethyl) N-Term(Dimethyl); CFVKLPEGTTPEK Q921I1 Serotransferrin C1(Carbamidomethyl); K4(Dimethyl); 1 1589.859 2.25 K13(Dimethyl) N-Term(Dimethyl); CFVKLPEGTTPEKYLGAEYMQSVGNM Q921I1 Serotransferrin C1(Carbamidomethyl); K4(Dimethyl); 1 3189.582 3.20 R K13(Dimethyl) Homogentisate 1,2- N-Term(Dimethyl); CFYNSDGDFLIVPQK O09173 4 1858.897 3.84 dioxygenase C1(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- CFYNSDGDFLIVPQK O09173 C1(Carbamidomethyl); 8 1874.982 4.37 dioxygenase K15(HeavyDimethyl) N-Term(Dimethyl); Homogentisate 1,2- CFYNSDGDFLIVPQKGK O09173 C1(Carbamidomethyl); K15(Dimethyl); 12 2072.041 4.89 dioxygenase K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- C1(Carbamidomethyl); CFYNSDGDFLIVPQKGK O09173 12 2096.186 5.52 dioxygenase K15(HeavyDimethyl); K17(HeavyDimethyl) N-Term(Dimethyl); CGEMAQAASAAVTR Q9Z1Q9 Valine--tRNA ligase 4 1450.673 2.81 C1(Carbamidomethyl) N-Term(Dimethyl); CGESPVWEEASQSLLFVDIPSK Q64374 Regucalcin 8 2534.261 5.36 C1(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CGESPVWEEASQSLLFVDIPSK Q64374 Regucalcin C1(Carbamidomethyl); 9 2550.360 5.79 K22(HeavyDimethyl) N-Term(Dimethyl); CGESPVWEEASQSLLFVDIPSKIICR Q64374 Regucalcin C1(Carbamidomethyl); K22(Dimethyl); 7 3076.562 5.48 C25(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CGESPVWEEASQSLLFVDIPSKIICR Q64374 Regucalcin 10 3092.638 6.66 K22(HeavyDimethyl); C25(Carbamidomethyl) N-Term(Dimethyl); CGESPVWEEASQSLLFVDIPSKIICRWD Q64374 Regucalcin C1(Carbamidomethyl); K22(Dimethyl); 1 4290.159 3.52 TVSNQVQR C25(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CGESPVWEEASQSLLFVDIPSKIICRWD C1(Carbamidomethyl); Q64374 Regucalcin 4 4306.238 5.65 TVSNQVQR K22(HeavyDimethyl); C25(Carbamidomethyl) Isoform Short of N-Term(Dimethyl); CGGDIAFHLNPR O08573-2 4 1384.674 2.74 Galectin-9 C1(Carbamidomethyl) Isoform Short of N-Term(Dimethyl:2H(6)13C(2)); CGGDIAFHLNPR O08573-2 2 1392.719 2.80 Galectin-9 C1(Carbamidomethyl) Succinate dehydrogenase N-Term(Dimethyl); CGPMVLDALIK Q9CQA3 1 1272.709 2.52 [ubiquinone] iron-sulfur C1(Carbamidomethyl); K11(Dimethyl) subunit, mitochondrial Long-chain-fatty-acid-- N-Term(Dimethyl); CGVEIISLK D3Z041 6 1074.623 2.58 CoA ligase 1 C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- CGVEIISLK D3Z041 C1(Carbamidomethyl); 8 1090.707 2.79 CoA ligase 1 K9(HeavyDimethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); CGVEIISLKALEDLGR D3Z041 1 1829.029 3.03 CoA ligase 1 C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- CGVEIISLKALEDLGR D3Z041 C1(Carbamidomethyl); 3 1845.111 3.09 CoA ligase 1 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- CGVEIISLKALEDLGRVNR D3Z041 C1(Carbamidomethyl); 1 2214.325 3.93 CoA ligase 1 K9(HeavyDimethyl) N-Term(Dimethyl); Long-chain-fatty-acid-- CGVEMLSLHDAENIGKENFK Q8JZR0 C1(Carbamidomethyl); K16(Dimethyl); 1 2375.141 2.48 CoA ligase 5 K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- C1(Carbamidomethyl); CGVEMLSLHDAENIGKENFK Q8JZR0 1 2399.308 2.92 CoA ligase 5 K16(HeavyDimethyl); K20(HeavyDimethyl) Isoform 2 of Centromere N-Term(Dimethyl); CGVQSFYTPR Q9CXS4-2 1 1242.587 2.15 protein V C1(Carbamidomethyl) Isoform 2 of Centromere N-Term(Dimethyl:2H(6)13C(2)); CGVQSFYTPR Q9CXS4-2 3 1250.635 2.82 protein V C1(Carbamidomethyl) 1,4-alpha-glucan- N-Term(Dimethyl); CGWLSAPQAYVSEK G3UW30 1 1651.811 2.22 branching enzyme C1(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 1,4-alpha-glucan- CGWLSAPQAYVSEK G3UW30 C1(Carbamidomethyl); 1 1667.903 2.29 branching enzyme K14(HeavyDimethyl) N-Term(Dimethyl); CGYAGSNFPEHIFPALVGRPIIR P61161 Actin-related protein 2 3 2599.357 3.88 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CGYAGSNFPEHIFPALVGRPIIR P61161 Actin-related protein 2 6 2607.417 3.38 C1(Carbamidomethyl) N-Term(Dimethyl); CGYDLDGCPVWYDIIGPLDAK Q99J08 SEC14-like protein 2 C1(Carbamidomethyl); 1 2483.165 3.29 C8(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CGYDLDGCPVWYDIIGPLDAK Q99J08 SEC14-like protein 2 2 2499.275 4.66 C8(Carbamidomethyl); K21(HeavyDimethyl)

NADH dehydrogenase N-Term(Dimethyl); CHAFEKEWIECAHGIGGTR B1ARW4 [ubiquinone] iron-sulfur C1(Carbamidomethyl); K6(Dimethyl); 1 2314.074 2.57 protein 5 (Fragment) C11(Carbamidomethyl)

Phosphorylase b kinase CHGLSVEGFVLPSSTTREMTPGEIKFSV C1(Carbamidomethyl); M19(Oxidation); A2AI91 regulatory subunit alpha, 1 4044.052 2.89 HVESVLNR K25(Dimethyl) skeletal muscle isoform Isoform 2 of Pleckstrin homology domain- N-Term(Dimethyl:2H(6)13C(2)); CHPDEVMSIRTANR Q8BW88-2 1 1721.847 2.07 containing family S C1(Carbamidomethyl) member 1 Glycine dehydrogenase N-Term(Dimethyl); CHPQTIAVVQTR Q91W43 (decarboxylating), 1 1437.761 2.45 C1(Carbamidomethyl) mitochondrial

Glycine dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); CHPQTIAVVQTR Q91W43 (decarboxylating), 1 1445.808 2.26 C1(Carbamidomethyl) mitochondrial Isoform Alpha-1 of N-Term(Dimethyl); CIAVGMAMDLVLDDSKRVAK P63058-2 Thyroid hormone C1(Carbamidomethyl); K16(Dimethyl); 2 2276.234 2.80 receptor alpha K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATP synthase F(0) C1(Carbamidomethyl); CIEDLKLLAK Q9CQQ7 complex subunit B1, 5 1310.909 2.42 K6(HeavyDimethyl); mitochondrial K10(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATP synthase F(0) C1(Carbamidomethyl); CIEDLKLLAKK Q9CQQ7 complex subunit B1, K6(HeavyDimethyl); 1 1475.083 2.37 mitochondrial K10(HeavyDimethyl); K11(HeavyDimethyl) N-Term(Dimethyl); CIEEAIDKLSK P15105 Glutamine synthetase C1(Carbamidomethyl); K8(Dimethyl); 5 1389.758 2.62 K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CIEEAIDKLSK P15105 Glutamine synthetase 7 1413.899 3.00 K8(HeavyDimethyl); K11(HeavyDimethyl) N-Term(Dimethyl); CIEEAIDKLSKR P15105 Glutamine synthetase C1(Carbamidomethyl); K8(Dimethyl); 10 1545.862 3.95 K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CIEEAIDKLSKR P15105 Glutamine synthetase 12 1569.990 4.24 K8(HeavyDimethyl); K11(HeavyDimethyl) Glucokinase regulatory N-Term(Dimethyl); CIESLLQVIHFPQPLSNDVR Q91X44 2 2393.260 3.42 protein C1(Carbamidomethyl) Short/branched chain N-Term(Dimethyl); specific acyl-CoA CIEWMGGVGYTKDYPVEK Q9DBL1 C1(Carbamidomethyl); K12(Dimethyl); 1 2216.087 2.80 dehydrogenase, K18(Dimethyl) mitochondrial Long-chain specific acyl- N-Term(Dimethyl); CIGAIAMTEPGAGSDLQGVR P51174 CoA dehydrogenase, 13 2030.996 6.75 C1(Carbamidomethyl) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl); CIGAIAMTEPGAGSDLQGVR P51174 CoA dehydrogenase, 5 2046.995 5.88 C1(Carbamidomethyl); M7(Oxidation) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); CIGAIAMTEPGAGSDLQGVR P51174 CoA dehydrogenase, 11 2039.040 6.53 C1(Carbamidomethyl) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); CIGAIAMTEPGAGSDLQGVR P51174 CoA dehydrogenase, 7 2055.033 6.54 C1(Carbamidomethyl); M7(Oxidation) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl); CIGAIAMTEPGAGSDLQGVRTNAK P51174 CoA dehydrogenase, 4 2473.256 4.47 C1(Carbamidomethyl); K24(Dimethyl) mitochondrial Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); CIGAIAMTEPGAGSDLQGVRTNAK P51174 CoA dehydrogenase, C1(Carbamidomethyl); 6 2489.342 5.12 mitochondrial K24(HeavyDimethyl)

Long-chain specific acyl- N-Term(Dimethyl); CIGAIAMTEPGAGSDLQGVRTNAKR P51174 CoA dehydrogenase, 2 2629.339 2.74 C1(Carbamidomethyl); K24(Dimethyl) mitochondrial

Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); CIGAIAMTEPGAGSDLQGVRTNAKR P51174 CoA dehydrogenase, C1(Carbamidomethyl); 4 2645.436 3.63 mitochondrial K24(HeavyDimethyl) A disintegrin and N-Term(Dimethyl); metalloproteinase with C1(Carbamidomethyl); K3(Dimethyl); CIKAGCDGNLGSKK P59384 1 1619.842 2.45 thrombospondin motifs C6(Carbamidomethyl); K13(Dimethyl); 15 K14(Dimethyl) Disintegrin and N-Term(Dimethyl:2H(6)13C(2)); metalloproteinase C1(Carbamidomethyl); CIKMKQVQSSPR O35227 2 1569.997 2.31 domain-containing K3(HeavyDimethyl); protein 7 K5(HeavyDimethyl) N-Term(Dimethyl); CIKNFPSSCVLGPEGTPASWTLMDQTG Isoform 2 of Glycine N- Q91XE0-2 C1(Carbamidomethyl); K3(Dimethyl); 2 3425.608 4.49 EMR acyltransferase C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CIKNFPSSCVLGPEGTPASWTLMDQTG Isoform 2 of Glycine N- C1(Carbamidomethyl); Q91XE0-2 4 3441.700 5.44 EMR acyltransferase K3(HeavyDimethyl); C9(Carbamidomethyl) C1(Carbamidomethyl); CILAECKSPPEAFGFEQATQEYTLQSFG Isoform 3 of Lysine- C6(Carbamidomethyl); Q62240-3 1 4104.979 3.11 EMADSFK specific demethylase 5D K7(HeavyDimethyl); M30(Oxidation); K35(HeavyDimethyl) N-Term(Dimethyl); CILLSNLSNTSHAPK P19096 Fatty acid synthase 8 1710.915 4.37 C1(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CILLSNLSNTSHAPK P19096 Fatty acid synthase C1(Carbamidomethyl); 17 1726.998 4.69 K15(HeavyDimethyl) N-Term(Dimethyl); CILTWHHQEPLPWAQSTGNQMSSR Q8BUV3 Gephyrin 1 2892.362 2.93 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CILTWHHQEPLPWAQSTGNQMSSR Q8BUV3 Gephyrin 3 2900.391 4.17 C1(Carbamidomethyl) N-Term(Dimethyl); 60 kDa heat shock CIPALDSLKPANEDQK P63038 C1(Carbamidomethyl); K9(Dimethyl); 10 1882.987 4.53 protein, mitochondrial K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60 kDa heat shock C1(Carbamidomethyl); CIPALDSLKPANEDQK P63038 8 1907.119 4.62 protein, mitochondrial K9(HeavyDimethyl); K16(HeavyDimethyl) N-Term(Dimethyl); 60 kDa heat shock CIPALDSLKPANEDQKIGIEIIKR P63038 C1(Carbamidomethyl); K9(Dimethyl); 1 2833.621 2.94 protein, mitochondrial K16(Dimethyl); K23(Dimethyl) Kynurenine 3- N-Term(Dimethyl); CIPEEGVLTVLGPDKVPR Q3V0K6 8 2035.129 3.50 monooxygenase C1(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Kynurenine 3- CIPEEGVLTVLGPDKVPR Q3V0K6 C1(Carbamidomethyl); 4 2051.220 3.15 monooxygenase K15(HeavyDimethyl) Glycine N- N-Term(Dimethyl); CIQIFPSSCLLGPEGTPVSWALMDQTG Q5FW57 acyltransferase-like C1(Carbamidomethyl); 1 3390.666 3.59 EIR protein C9(Carbamidomethyl) Glycine N- N-Term(Dimethyl:2H(6)13C(2)); CIQIFPSSCLLGPEGTPVSWALMDQTG Q5FW57 acyltransferase-like C1(Carbamidomethyl); 3 3398.723 4.26 EIR protein C9(Carbamidomethyl) Isoform 2 of Ras and EF- C1(Carbamidomethyl); K9(Dimethyl); CISAYLGEKLAMTYGALFCETSAK Q5RI75-2 hand domain-containing M12(Oxidation); 1 2756.304 3.01 protein homolog C19(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl); CISFRDHMK Q921I1 Serotransferrin 3 1249.614 2.33 C1(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CISFRDHMK Q921I1 Serotransferrin C1(Carbamidomethyl); 2 1265.702 2.39 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CIVNNVSAETVQTVR D3Z3F8 Spartin 1 1725.929 2.90 C1(Carbamidomethyl) N-Term(Dimethyl); CIYINQWQVNHDEK P00186 Cytochrome P450 1A2 8 1902.912 4.22 C1(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CIYINQWQVNHDEK P00186 Cytochrome P450 1A2 C1(Carbamidomethyl); 8 1919.000 4.44 K14(HeavyDimethyl) N-Term(Dimethyl); CKAAVLWELHKPFTIEDIEVAPPKAHE Alcohol dehydrogenase P00329 C1(Carbamidomethyl); K2(Dimethyl); 1 3495.921 4.07 VR 1 K11(Dimethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CKAAVLWELHKPFTIEDIEVAPPKAHE Alcohol dehydrogenase P00329 K2(HeavyDimethyl); 1 3528.103 3.65 VR 1 K11(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl); CKDDEFTHLYTLIVRPDNTYEVK P14211 Calreticulin C1(Carbamidomethyl); K2(Dimethyl); 3 2940.485 3.12 K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CKDDEFTHLYTLIVRPDNTYEVK P14211 Calreticulin 2 2964.619 2.86 K2(HeavyDimethyl); K23(HeavyDimethyl) N-Term(Dimethyl); 40S ribosomal protein CKELGITALHIK D3YVF4 C1(Carbamidomethyl); K2(Dimethyl); 12 1466.872 4.42 S14 (Fragment) K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein C1(Carbamidomethyl); CKELGITALHIK D3YVF4 7 1491.004 3.48 S14 (Fragment) K2(HeavyDimethyl); K12(HeavyDimethyl) Aconitate hydratase, N-Term(Dimethyl); CKSQFTITPGSEQIR Q99KI0 8 1807.928 3.81 mitochondrial C1(Carbamidomethyl); K2(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, CKSQFTITPGSEQIR Q99KI0 C1(Carbamidomethyl); 7 1824.020 3.65 mitochondrial K2(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl); CLAPMMSEVMR Q8BMS1 subunit alpha, 2 1352.621 2.60 C1(Carbamidomethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); CLAPMMSEVMR Q8BMS1 subunit alpha, 1 1360.657 2.45 C1(Carbamidomethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); CLAPMMSEVMRILQEGVDPK Q8BMS1 subunit alpha, C1(Carbamidomethyl); 1 2376.286 2.44 mitochondrial K20(HeavyDimethyl) Glutathione S- N-Term(Dimethyl); CLDAFPNLKDFIAR D3YVP5 1 1735.898 2.41 transferase Mu 7 C1(Carbamidomethyl); K9(Dimethyl) Glutathione S- N-Term(Dimethyl); CLDAFPNLR P10649 2 1133.576 2.25 transferase Mu 1 C1(Carbamidomethyl) Glutathione S- N-Term(Dimethyl:2H(6)13C(2)); CLDAFPNLR P10649 3 1141.623 2.15 transferase Mu 1 C1(Carbamidomethyl) Glutathione S- N-Term(Dimethyl); CLDAFPNLRDFLAR P10649 1 1735.889 2.30 transferase Mu 1 C1(Carbamidomethyl) Glutathione S- N-Term(Dimethyl:2H(6)13C(2)); CLDAFPNLRDFLAR P10649 4 1743.944 2.68 transferase Mu 1 C1(Carbamidomethyl) Cullin-associated C1(Carbamidomethyl); M12(Oxidation); CLDAVVSTRHEMLPEFYKTVSPALIAR Q6ZQ38 NEDD8-dissociated 1 3155.681 2.69 K18(HeavyDimethyl) protein 1 Cytochrome c oxidase N-Term(Dimethyl); CLDDNAEDAAR Q8BGD8 assembly factor 6 1 1277.540 2.20 C1(Carbamidomethyl) homolog N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CLDVDECETVVCPGENEKCENTEGGY Cysteine-rich with EGF- C7(Carbamidomethyl); Q91XD7 1 3291.455 3.11 R like domain protein 1 C12(Carbamidomethyl); K18(HeavyDimethyl); C19(Carbamidomethyl) Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate CLEEVEDLIVKYR P61922-2 C1(Carbamidomethyl); 4 1738.006 2.75 aminotransferase, K11(HeavyDimethyl) mitochondrial Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate C1(Carbamidomethyl); CLEEVEDLIVKYRK P61922-2 1 1902.186 2.88 aminotransferase, K11(HeavyDimethyl); mitochondrial K14(HeavyDimethyl) N-Term(Dimethyl); Heat shock protein HSP CLELFSELAEDKENYKK P11499 C1(Carbamidomethyl); K12(Dimethyl); 5 2228.151 4.54 90-beta K16(Dimethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); Heat shock protein HSP CLELFSELAEDKENYKK P11499 K12(HeavyDimethyl); 6 2260.323 3.63 90-beta K16(HeavyDimethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); Heat shock protein HSP CLELFTELAEDKENYKK P07901 K12(HeavyDimethyl); 1 2274.349 2.80 90-alpha K16(HeavyDimethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CLGELICTLNAANVPAGTEVVCAPPTA Triosephosphate C1(Carbamidomethyl); P17751 3 3599.841 3.09 YIDFAR isomerase C7(Carbamidomethyl); C22(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CLGHPEEFYNLLR P53798 Squalene synthase 1 1683.874 2.39 C1(Carbamidomethyl) Carbamoyl-phosphate N-Term(Dimethyl); CLGLTEAQTR Q8C196 synthase [ammonia], 44 1176.601 3.71 C1(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); CLGLTEAQTR Q8C196 synthase [ammonia], 40 1184.644 3.38 C1(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); CLGLTEAQTRELR Q8C196 synthase [ammonia], 13 1574.830 3.12 C1(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); CLGLTEAQTRELR Q8C196 synthase [ammonia], 16 1582.871 3.22 C1(Carbamidomethyl) mitochondrial Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)); CLGNSQDALQFFQR E9PV21 1 1719.863 2.48 protein 39C C1(Carbamidomethyl) N-Term(Dimethyl); CLHTFTNNVIAER Q9DBW0 Cytochrome P450 4V2 3 1602.802 2.65 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CLHTFTNNVIAER Q9DBW0 Cytochrome P450 4V2 1 1610.851 2.80 C1(Carbamidomethyl) N-Term(Dimethyl); CLKDGGGDVAFVK Q921I1 Serotransferrin C1(Carbamidomethyl); K3(Dimethyl); 6 1449.775 2.65 K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CLKDGGGDVAFVK Q921I1 Serotransferrin 6 1473.905 2.98 K3(HeavyDimethyl); K13(HeavyDimethyl) Lysophosphatidic acid N-Term(Dimethyl); CLLAGLFQHQK Q8BP40 2 1370.766 2.61 phosphatase type 6 C1(Carbamidomethyl); K11(Dimethyl) Isoform 3 of Cas CLLHGRQGLAPANR Q08EC4-3 scaffolding protein C1(Carbamidomethyl) 1 1562.829 1.92 family member 4 Mitochondrial N-Term(Dimethyl); CLLQIQASSGENK Q9Z2Z6 carnitine/acylcarnitine 2 1503.780 2.16 C1(Carbamidomethyl); K13(Dimethyl) carrier protein Mitochondrial N-Term(Dimethyl); CLLTTVDPDTGISDR Q9CW42 amidoxime-reducing 5 1690.828 3.71 C1(Carbamidomethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); CLLTTVDPDTGISDR Q9CW42 amidoxime-reducing 4 1698.879 3.53 C1(Carbamidomethyl) component 1 Mitochondrial N-Term(Dimethyl); CLLTTVDPDTGISDRKEPLETLK Q9CW42 amidoxime-reducing C1(Carbamidomethyl); K16(Dimethyl); 5 2685.432 3.47 component 1 K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Mitochondrial C1(Carbamidomethyl); CLLTTVDPDTGISDRKEPLETLK Q9CW42 amidoxime-reducing 6 2709.564 3.57 K16(HeavyDimethyl); component 1 K23(HeavyDimethyl) GDH/6PGL N-Term(Dimethyl); CLPQQIIFYIGHGELGHPAILVSR Q8CFX1 endoplasmic 3 2746.494 3.96 C1(Carbamidomethyl) bifunctional protein GDH/6PGL N-Term(Dimethyl:2H(6)13C(2)); CLPQQIIFYIGHGELGHPAILVSR Q8CFX1 endoplasmic 2 2754.549 3.77 C1(Carbamidomethyl) bifunctional protein Glycerol-3-phosphate N-Term(Dimethyl); CLQNHPEHM E0CXN5 dehydrogenase 1 1193.516 2.36 C1(Carbamidomethyl) [NAD(+)], cytoplasmic

Glycerol-3-phosphate N-Term(Dimethyl:2H(6)13C(2)); CLQNHPEHM E0CXN5 dehydrogenase 6 1201.560 2.77 C1(Carbamidomethyl) [NAD(+)], cytoplasmic N-Term(Dimethyl:2H(6)13C(2)); Isoform 5 of C1(Carbamidomethyl); CLSILVQLYGGENPESLSPENMVTFAN Q3V129-5 Serine/threonine-protein K32(HeavyDimethyl); 1 4553.493 3.59 LLMTKEDPKDQK kinase ULK4 K36(HeavyDimethyl); K39(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein transport protein CLSSATDPQTK S4R2A9 C1(Carbamidomethyl); 1 1279.714 1.90 Sec31A (Fragment) K11(HeavyDimethyl) Protein transport protein N-Term(Dimethyl); CLSSATDPQTKR S4R2A9 3 1419.722 3.03 Sec31A (Fragment) C1(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein transport protein CLSSATDPQTKR S4R2A9 C1(Carbamidomethyl); 2 1435.812 2.45 Sec31A (Fragment) K11(HeavyDimethyl) Isoform 3 of CLSTGSQAPDAPSGPGPTSNQLTHVDS N-Term(Dimethyl:2H(6)13C(2)); Q5RKZ7-3 Molybdenum cofactor 1 3001.469 2.85 AGR C1(Carbamidomethyl) biosynthesis protein 1 N-Term(Dimethyl); 25-hydroxycholesterol 7- CLTSEKVAQMQGQSK Q60991 C1(Carbamidomethyl); K6(Dimethyl); 4 1778.907 4.41 alpha-hydroxylase K15(Dimethyl) Flavin reductase N-Term(Dimethyl); CLTTNEYDGHTTYPSHQYD E9PZC4 16 2329.959 4.93 (NADPH) C1(Carbamidomethyl) Flavin reductase N-Term(Dimethyl:2H(6)13C(2)); CLTTNEYDGHTTYPSHQYD E9PZC4 13 2338.005 4.75 (NADPH) C1(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); CLVEELR Q91X77-2 6 946.499 2.92 Cytochrome P450 2C50 C1(Carbamidomethyl)

Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); CLVEELR Q91X77-2 4 954.544 2.70 Cytochrome P450 2C50 C1(Carbamidomethyl) N-Term(Dimethyl); CLVEKGDVAFVK Q921I1 Serotransferrin C1(Carbamidomethyl); K5(Dimethyl); 7 1448.815 2.81 K12(Dimethyl) Synaptic vesicle N-Term(Dimethyl); CLVLTGFGGYDKVK Q62465 membrane protein VAT- C1(Carbamidomethyl); K12(Dimethyl); 1 1640.907 2.47 1 homolog K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Synaptic vesicle C1(Carbamidomethyl); CLVLTGFGGYDKVK Q62465 membrane protein VAT- 1 1665.039 2.46 K12(HeavyDimethyl); 1 homolog K14(HeavyDimethyl) N-Term(Dimethyl); CLYASVLTAQPR P58252 Elongation factor 2 13 1406.743 3.33 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CLYASVLTAQPR P58252 Elongation factor 2 6 1414.789 3.56 C1(Carbamidomethyl) Methylmalonate- semialdehyde N-Term(Dimethyl); CMALSTAILVGEAK Q9EQ20 dehydrogenase 4 1519.825 2.81 C1(Carbamidomethyl); K14(Dimethyl) [acylating], mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl:2H(6)13C(2)); CMALSTAILVGEAK Q9EQ20 dehydrogenase C1(Carbamidomethyl); 6 1535.910 3.62 [acylating], K14(HeavyDimethyl) mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl); CMALSTAILVGEAKK Q9EQ20 dehydrogenase C1(Carbamidomethyl); K14(Dimethyl); 4 1675.944 2.84 [acylating], K15(Dimethyl) mitochondrial Methylmalonate- N-Term(Dimethyl:2H(6)13C(2)); semialdehyde C1(Carbamidomethyl); CMALSTAILVGEAKK Q9EQ20 dehydrogenase 9 1700.082 4.05 K14(HeavyDimethyl); [acylating], K15(HeavyDimethyl) mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl); CMALSTAILVGEAKKWLPELVDR Q9EQ20 dehydrogenase C1(Carbamidomethyl); K14(Dimethyl); 7 2684.481 3.73 [acylating], K15(Dimethyl) mitochondrial Methylmalonate- N-Term(Dimethyl:2H(6)13C(2)); semialdehyde C1(Carbamidomethyl); CMALSTAILVGEAKKWLPELVDR Q9EQ20 dehydrogenase 1 2708.617 2.77 K14(HeavyDimethyl); [acylating], K15(HeavyDimethyl) mitochondrial 60S ribosomal protein N-Term(Dimethyl); CMQLTDFILKFPHSAR Q9CR57 1 2020.065 2.69 L14 C1(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein CMQLTDFILKFPHSAR Q9CR57 C1(Carbamidomethyl); 3 2036.132 2.91 L14 K10(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Vacuolar protein sorting- C1(Carbamidomethyl); CMQYLDRAEKLK Q8VEJ9 2 1663.015 2.27 associated protein 4A K10(HeavyDimethyl); K12(HeavyDimethyl) Aldehyde N-Term(Dimethyl); CMTEEIFGPVTCVVPFDSEEEVITR Q8BH00 dehydrogenase family 8 C1(Carbamidomethyl); 5 2972.375 4.63 member A1 C12(Carbamidomethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); CMTEEIFGPVTCVVPFDSEEEVITR Q8BH00 dehydrogenase family 8 C1(Carbamidomethyl); 3 2980.426 4.50 member A1 C12(Carbamidomethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); CMTEEIFGPVTCVVPFDSEEEVITRANS Q8BH00 dehydrogenase family 8 C1(Carbamidomethyl); 1 3507.701 3.51 VR member A1 C12(Carbamidomethyl) N-Term(Dimethyl); CNEPAVWSQLAK Q68FD5 Clathrin heavy chain 1 1 1458.739 2.17 C1(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); Lysosomal protective CNFYDNKDPECVNNLLEVSR P16675 C1(Carbamidomethyl); K7(Dimethyl); 2 2542.165 3.24 protein C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein Sec24b CNLCYRVNDVPEEFLYNPLTR F6VJC5 C1(Carbamidomethyl); 2 2708.340 2.83 (Fragment) C4(Carbamidomethyl) 4- N-Term(Dimethyl); CNLEIIDHIVGNQPDQEMQSASEWYLK P49429 hydroxyphenylpyruvate 3 3273.561 5.03 C1(Carbamidomethyl); K27(Dimethyl) dioxygenase 4- N-Term(Dimethyl:2H(6)13C(2)); CNLEIIDHIVGNQPDQEMQSASEWYLK P49429 hydroxyphenylpyruvate C1(Carbamidomethyl); 5 3289.632 5.04 dioxygenase K27(HeavyDimethyl) 4- CNLEIIDHIVGNQPDQEMQSASEWYLK N-Term(Dimethyl); P49429 hydroxyphenylpyruvate 1 4068.990 3.28 NLQFHR C1(Carbamidomethyl); K27(Dimethyl) dioxygenase 4- N-Term(Dimethyl:2H(6)13C(2)); CNLEIIDHIVGNQPDQEMQSASEWYLK P49429 hydroxyphenylpyruvate C1(Carbamidomethyl); 4 4085.070 4.14 NLQFHR dioxygenase K27(HeavyDimethyl) C1(Carbamidomethyl); CNLPPAEECTQLAETARADGNVFETIK Q8CFX0 Protein Wdr17 C9(Carbamidomethyl); 1 3070.481 2.96 K27(HeavyDimethyl) N-Term(Dimethyl); Prolow-density C1(Carbamidomethyl); CNMFDDCGDGSDEEDCSIDPK Q91ZX7 lipoprotein receptor- 5 2521.911 4.22 C7(Carbamidomethyl); related protein 1 C16(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Prolow-density C1(Carbamidomethyl); CNMFDDCGDGSDEEDCSIDPK Q91ZX7 lipoprotein receptor- C7(Carbamidomethyl); 1 2538.002 2.25 related protein 1 C16(Carbamidomethyl); K21(HeavyDimethyl) Alanine N-Term(Dimethyl); CNPVQGAMYSFPQIQLPLK Q8QZR5 9 2247.180 5.00 aminotransferase 1 C1(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine CNPVQGAMYSFPQIQLPLK Q8QZR5 C1(Carbamidomethyl); 8 2263.255 5.21 aminotransferase 1 K19(HeavyDimethyl)

C1(Carbamidomethyl); K4(Dimethyl); Isoform 4 of LIM CNTKIMGEVMHALRQTWHTTCFVCA M6(Oxidation); C21(Carbamidomethyl); Q9JKS4-4 domain-binding protein 1 3482.653 3.16 ACK C24(Carbamidomethyl); 3 C27(Carbamidomethyl); K28(Dimethyl)

N-Term(Dimethyl); CNVSNTHTSHCLASGEVMVNTLGDLQ Selenium-binding G3UYY2 C1(Carbamidomethyl); 1 3256.507 4.09 GNGK protein 2 C11(Carbamidomethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CNVSNTHTSHCLASGEVMVNTLGDLQ Selenium-binding C1(Carbamidomethyl); G3UYY2 3 3272.611 3.91 GNGK protein 2 C11(Carbamidomethyl); K30(HeavyDimethyl) N-Term(Dimethyl); CPAGVVPACHNSEDTVTISGPQAAVNE C1(Carbamidomethyl); P19096 Fatty acid synthase 1 4368.140 3.51 FVEQLKQEGVFAK C9(Carbamidomethyl); K33(Dimethyl); K40(Dimethyl) N-Term(Dimethyl); CPAGVVPACHNSEDTVTISGPQAAVNE C1(Carbamidomethyl); P19096 Fatty acid synthase 1 4752.370 3.44 FVEQLKQEGVFAKEVR C9(Carbamidomethyl); K33(Dimethyl); K40(Dimethyl) N-Term(Dimethyl); CPEALFQPSFLGMESCGIHETTFNSIMK E9Q1F2 Actin, cytoplasmic 1 C1(Carbamidomethyl); 2 3287.532 3.14 C16(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CPEALFQPSFLGMESCGIHETTFNSIMK E9Q1F2 Actin, cytoplasmic 1 1 3303.621 3.28 C16(Carbamidomethyl); K28(HeavyDimethyl) N-Term(Dimethyl); 5-hydroxyisourate CPGLLTPSQIKPGTYK Q9CRB3 C1(Carbamidomethyl); K11(Dimethyl); 5 1844.028 3.76 hydrolase K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 5-hydroxyisourate C1(Carbamidomethyl); CPGLLTPSQIKPGTYK Q9CRB3 5 1868.162 3.24 hydrolase K11(HeavyDimethyl); K16(HeavyDimethyl) N-Term(Dimethyl); CPVMLVVGDQAPHEDAVVECNSKLDP Isoform 2 of Protein C1(Carbamidomethyl); Q9QYG0-2 1 3768.880 3.00 TQTSFLK NDRG2 C20(Carbamidomethyl); K23(Dimethyl); K33(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CPVMLVVGDQAPHEDAVVECNSKLDP Isoform 2 of Protein Q9QYG0-2 C20(Carbamidomethyl); 2 3793.028 4.04 TQTSFLK NDRG2 K23(HeavyDimethyl); K33(HeavyDimethyl) Isoform LMW of N-Term(Dimethyl); CQALDMTEMAR O08677-2 1 1353.597 2.18 Kininogen-1 C1(Carbamidomethyl) N-Term(Dimethyl); CQEKVSQLYMNQK Q3UEJ6 Phosphorylase C1(Carbamidomethyl); K4(Dimethyl); 3 1739.879 3.58 K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CQEKVSQLYMNQK Q3UEJ6 Phosphorylase 1 1764.007 2.93 K4(HeavyDimethyl); K13(HeavyDimethyl) N-Term(Dimethyl); CQLEINFNTLQTK A1BN54 Alpha actinin 1a 2 1664.858 2.70 C1(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CQLEINFNTLQTK A1BN54 Alpha actinin 1a C1(Carbamidomethyl); 3 1680.954 2.95 K13(HeavyDimethyl) Sarcosine N-Term(Dimethyl); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 2 2323.069 5.19 C1(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 4 2339.066 4.43 C1(Carbamidomethyl); M12(Oxidation) mitochondrial Sarcosine N-Term(Dimethyl); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 4 2339.062 5.29 C1(Carbamidomethyl); M4(Oxidation) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 11 2331.118 6.74 C1(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 2 2347.118 4.01 C1(Carbamidomethyl); M12(Oxidation) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); CQLMDSSEDLGMLSIQGPASR Q99LB7 dehydrogenase, 1 2347.108 4.60 C1(Carbamidomethyl); M4(Oxidation) mitochondrial Probable D-lactate N-Term(Dimethyl); CQPPDAVVWPQNVDQVSR Q7TNG8 dehydrogenase, 9 2123.038 4.15 C1(Carbamidomethyl) mitochondrial Probable D-lactate N-Term(Dimethyl:2H(6)13C(2)); CQPPDAVVWPQNVDQVSR Q7TNG8 dehydrogenase, 6 2131.068 4.36 C1(Carbamidomethyl) mitochondrial 4- N-Term(Dimethyl); CQVLLEAAR Q9JLJ2 trimethylaminobutyralde 3 1087.590 2.52 C1(Carbamidomethyl) hyde dehydrogenase

4- N-Term(Dimethyl:2H(6)13C(2)); CQVLLEAAR Q9JLJ2 trimethylaminobutyralde 7 1095.634 2.92 C1(Carbamidomethyl) hyde dehydrogenase CRNPEWGLRDTVLLEELGQASGLVLE N-Term(Dimethyl); G5E8X1 Protein 0610011F06Rik 1 3138.642 2.78 R C1(Carbamidomethyl) CRNPEWGLRDTVLLEELGQASGLVLE N-Term(Dimethyl:2H(6)13C(2)); G5E8X1 Protein 0610011F06Rik 2 3146.693 2.84 R C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CRQEVQELLR B8JK07 Protein Cyp4f13 1 1366.764 2.58 C1(Carbamidomethyl) N-Term(Dimethyl); C1(Carbamidomethyl); CSANCCEDTQASMQQVHQCIER Q9CR98 Protein FAM136A C5(Carbamidomethyl); 3 2740.098 3.58 C6(Carbamidomethyl); C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CSANCCEDTQASMQQVHQCIER Q9CR98 Protein FAM136A C5(Carbamidomethyl); 1 2748.141 3.00 C6(Carbamidomethyl); C19(Carbamidomethyl) Probable N-Term(Dimethyl); CSAVLLPTTAYMLR Q9DBA8 13 1623.865 3.54 imidazolonepropionase C1(Carbamidomethyl)

Probable N-Term(Dimethyl:2H(6)13C(2)); CSAVLLPTTAYMLR Q9DBA8 3 1631.901 2.87 imidazolonepropionase C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CSETGGSVVELPTVSQEPSGPSDSETD C1(Carbamidomethyl); P20918 Plasminogen 1 4067.877 4.45 CMYGNGKDYR C28(Carbamidomethyl); K34(HeavyDimethyl) Glycerol-3-phosphate N-Term(Dimethyl); CSGGSAGGLGNLISQEQLVR Q61586 acyltransferase 1, 1 2031.031 3.73 C1(Carbamidomethyl) mitochondrial Nicotinate-nucleotide N-Term(Dimethyl); CSGIASAAATAVEVAR Q91X91 pyrophosphorylase 12 1561.802 4.69 C1(Carbamidomethyl) [carboxylating] Nicotinate-nucleotide N-Term(Dimethyl:2H(6)13C(2)); CSGIASAAATAVEVAR Q91X91 pyrophosphorylase 20 1569.843 5.03 C1(Carbamidomethyl) [carboxylating] Nicotinate-nucleotide CSGIASAAATAVEVARSTGWTGHVAG N-Term(Dimethyl:2H(6)13C(2)); Q91X91 pyrophosphorylase 1 2780.438 3.78 TR C1(Carbamidomethyl) [carboxylating] Dimethylglycine CSMGFHAGWEQPHWFYKPGQDTQYR N-Term(Dimethyl); Q9DBT9 dehydrogenase, 1 3656.659 3.29 PSFR C1(Carbamidomethyl); K17(Dimethyl) mitochondrial Peroxisomal carnitine O- N-Term(Dimethyl); CSNEPVGPSIAALTSEER Q9DC50 2 1944.927 3.39 octanoyltransferase C1(Carbamidomethyl) Transmembrane protein C1(Carbamidomethyl); CSNLWLFLETGQLPKDISTDPHD F8WGV9 1 2722.360 2.20 141 (Fragment) K15(HeavyDimethyl) N-Term(Dimethyl); CSPDPGLTALLSDHR Q91X72 Hemopexin 5 1666.816 4.06 C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CSPDPGLTALLSDHR Q91X72 Hemopexin 6 1674.868 3.89 C1(Carbamidomethyl) CSPDPGLTALLSDHRGATYAFTGSHY N-Term(Dimethyl); Q91X72 Hemopexin 2 3164.504 3.41 WR C1(Carbamidomethyl) C1(Carbamidomethyl); M9(Oxidation); M19(Oxidation); CSSLFNQPMYYFLSHLASMDICYTSCV Q7TR17 Olfactory receptor C22(Carbamidomethyl); 1 4669.253 2.98 TPKLIGDLLAER C26(Carbamidomethyl); K30(HeavyDimethyl) N-Term(Dimethyl); CSSMQKFGER P07724 Serum albumin 1 1285.599 2.41 C1(Carbamidomethyl); K6(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CSSMQKFGER P07724 Serum albumin C1(Carbamidomethyl); 5 1301.687 3.34 K6(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CSTFGDAGILGCVSINSNTDEDDVVEG Zinc finger BED domain- C12(Carbamidomethyl); D2EAC2 1 4278.212 3.61 KMVAEGANKETK containing protein 6 K28(HeavyDimethyl); M29(Oxidation); K36(HeavyDimethyl); K39(HeavyDimethyl)

Oxygen-dependent N-Term(Dimethyl); CSTFMSSPVTELR P36552 coproporphyrinogen-III 1 1542.727 2.68 C1(Carbamidomethyl) oxidase, mitochondrial

Oxygen-dependent N-Term(Dimethyl:2H(6)13C(2)); CSTFMSSPVTELR P36552 coproporphyrinogen-III 1 1550.771 2.60 C1(Carbamidomethyl) oxidase, mitochondrial N-Term(Dimethyl); CSYDEHAKLVQEVTDFAK P07724 Serum albumin C1(Carbamidomethyl); K8(Dimethyl); 12 2224.093 4.25 K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CSYDEHAKLVQEVTDFAK P07724 Serum albumin 6 2248.228 4.21 K8(HeavyDimethyl); K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CSYTVEAHCR Q01339 Beta-2-glycoprotein 1 C1(Carbamidomethyl); 1 1318.607 2.29 C9(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); CTGGEVGATSALAPK P35979 9 1474.754 5.52 L12 C1(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein CTGGEVGATSALAPK P35979 C1(Carbamidomethyl); 2 1490.841 5.08 L12 K15(HeavyDimethyl) N-Term(Dimethyl); 60S ribosomal protein CTGGEVGATSALAPKIGPLGLSPK P35979 C1(Carbamidomethyl); K15(Dimethyl); 1 2365.311 4.25 L12 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein C1(Carbamidomethyl); CTGGEVGATSALAPKIGPLGLSPK P35979 1 2389.451 2.59 L12 K15(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CTGYRPIVESAK G3X982 Aldehyde oxidase 3 C1(Carbamidomethyl); 3 1452.840 2.75 K12(HeavyDimethyl) C-1-tetrahydrofolate CTHWAEGGQGALALAQAVQR Q922D8 C1(Carbamidomethyl) 2 2124.041 2.88 synthase, cytoplasmic C-1-tetrahydrofolate N-Term(Dimethyl); CTHWAEGGQGALALAQAVQR Q922D8 4 2152.062 6.62 synthase, cytoplasmic C1(Carbamidomethyl) C-1-tetrahydrofolate N-Term(Dimethyl:2H(6)13C(2)); CTHWAEGGQGALALAQAVQR Q922D8 3 2160.111 6.42 synthase, cytoplasmic C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CTIKPSGTTISITASVTITLAPPMLPEVE Phospholipid transfer C1(Carbamidomethyl); A2A5K2 1 3464.069 3.09 LSK protein K4(HeavyDimethyl); K32(HeavyDimethyl) Inositol hexakisphosphate and CTQWGQIMPMLKLESLQLWMGRLNE C1(Carbamidomethyl); F6VU93 diphosphoinositol- 1 3454.771 2.85 TVR K12(HeavyDimethyl) pentakisphosphate kinase 1 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CTSYNIPCTSDMAK G3X972 Protein Sec24c 1 1719.826 2.85 C8(Carbamidomethyl); K14(HeavyDimethyl) Aconitate hydratase, N-Term(Dimethyl); CTTDHISAAGPWLK Q99KI0 6 1612.808 3.60 mitochondrial C1(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, CTTDHISAAGPWLK Q99KI0 C1(Carbamidomethyl); 6 1628.898 3.78 mitochondrial K14(HeavyDimethyl) N-Term(Dimethyl); CTTPPPPPSPTYQCLK P20918 Plasminogen C1(Carbamidomethyl); 9 1899.926 3.16 C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C1(Carbamidomethyl); CTTPPPPPSPTYQCLK P20918 Plasminogen 1 1916.013 2.30 C14(Carbamidomethyl); K16(HeavyDimethyl) N-Term(Dimethyl); C1(Carbamidomethyl); Prolow-density CVAEALLCNGQDDCGDGSDERGCHV C8(Carbamidomethyl); Q91ZX7 lipoprotein receptor- 1 3581.459 3.85 NECLSR C14(Carbamidomethyl); related protein 1 C23(Carbamidomethyl); C28(Carbamidomethyl) N-Term(Dimethyl); DNA-directed RNA C1(Carbamidomethyl); CVCFFCSKLLVDSNNPK P08775 polymerase II subunit C3(Carbamidomethyl); 1 2172.096 2.45 RPB1 C6(Carbamidomethyl); K8(Dimethyl); K17(Dimethyl) Isoform Short of DNA- CVEALLARGADLTTEADSGYTPMDLA N-Term(Dimethyl); Q9Z205-2 binding protein 1 3443.632 2.87 VALGYR C1(Carbamidomethyl); M23(Oxidation) RFXANK CVEELPEWNFDGSSTFQSEGSNSDMYL N-Term(Dimethyl:2H(6)13C(2)); P15105 Glutamine synthetase 1 4518.068 4.17 HPVAMFRDPFR C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- C1(Carbamidomethyl); CVESAKKIFS P30115 3 1276.824 2.83 transferase A3 K6(HeavyDimethyl); K7(HeavyDimethyl) Glutamate N-Term(Dimethyl); CVGVGESDGSIWNPDGIDPK P26443 dehydrogenase 1, 12 2158.012 5.89 C1(Carbamidomethyl); K20(Dimethyl) mitochondrial Glutamate N-Term(Dimethyl:2H(6)13C(2)); CVGVGESDGSIWNPDGIDPK P26443 dehydrogenase 1, C1(Carbamidomethyl); 19 2174.098 6.15 mitochondrial K20(HeavyDimethyl) Glutamate N-Term(Dimethyl); CVGVGESDGSIWNPDGIDPKELEDFKL P26443 dehydrogenase 1, C1(Carbamidomethyl); K20(Dimethyl); 10 4153.092 5.37 QHGSILGFPK mitochondrial K26(Dimethyl); K37(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate C1(Carbamidomethyl); CVGVGESDGSIWNPDGIDPKELEDFKL P26443 dehydrogenase 1, K20(HeavyDimethyl); 8 4185.267 5.50 QHGSILGFPK mitochondrial K26(HeavyDimethyl); K37(HeavyDimethyl) Aconitate hydratase, N-Term(Dimethyl); CVIKHPNGTQETILLNHTFNETQIEWFR Q99KI0 4 3481.768 4.72 mitochondrial C1(Carbamidomethyl); K4(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, CVIKHPNGTQETILLNHTFNETQIEWFR Q99KI0 C1(Carbamidomethyl); 5 3497.862 4.27 mitochondrial K4(HeavyDimethyl) NADH-ubiquinone N-Term(Dimethyl); CVKAVTEGAQAVEEPSIC Q91VD9 oxidoreductase 75 kDa C1(Carbamidomethyl); K3(Dimethyl); 7 2003.972 4.64 subunit, mitochondrial C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NADH-ubiquinone C1(Carbamidomethyl); CVKAVTEGAQAVEEPSIC Q91VD9 oxidoreductase 75 kDa 9 2020.064 4.70 K3(HeavyDimethyl); subunit, mitochondrial C18(Carbamidomethyl) CVLIFGVPSRVPKDEQGSAADSEDSPTI Delta-aminolevulinic N-Term(Dimethyl); P10518 1 3485.759 4.45 EAVR acid dehydratase C1(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CVLIFGVPSRVPKDEQGSAADSEDSPTI Delta-aminolevulinic P10518 C1(Carbamidomethyl); 4 3501.845 5.33 EAVR acid dehydratase K13(HeavyDimethyl) DnaJ homolog subfamily N-Term(Dimethyl); CVLNEGMPIYR P63037 4 1379.680 2.49 A member 1 C1(Carbamidomethyl) Serine-threonine kinase N-Term(Dimethyl); CVLPEEDSGELAKPK Q9Z1Z2 receptor-associated C1(Carbamidomethyl); K13(Dimethyl); 3 1755.915 2.70 protein K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Serine-threonine kinase C1(Carbamidomethyl); CVLPEEDSGELAKPK Q9Z1Z2 receptor-associated 4 1780.045 2.35 K13(HeavyDimethyl); protein K15(HeavyDimethyl) Probable N-Term(Dimethyl); CVLPGLVDAHTHPVWAGER Q9DBA8 2 2142.092 2.86 imidazolonepropionase C1(Carbamidomethyl) Mitochondrial N-Term(Dimethyl); CVLTTVDPDTGIIDR Q922Q1 amidoxime reducing 2 1702.865 3.00 C1(Carbamidomethyl) component 2 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); CVLTTVDPDTGIIDR Q922Q1 amidoxime reducing 3 1710.907 3.53 C1(Carbamidomethyl) component 2 Mitochondrial N-Term(Dimethyl); CVLTTVDPDTGIIDRK Q922Q1 amidoxime reducing 11 1858.987 4.41 C1(Carbamidomethyl); K16(Dimethyl) component 2 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); CVLTTVDPDTGIIDRK Q922Q1 amidoxime reducing C1(Carbamidomethyl); 7 1875.081 4.60 component 2 K16(HeavyDimethyl) Mitochondrial N-Term(Dimethyl); CVLTTVDPDTGIIDRKEPLETLK Q922Q1 amidoxime reducing C1(Carbamidomethyl); K16(Dimethyl); 7 2697.472 4.39 component 2 K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Mitochondrial C1(Carbamidomethyl); CVLTTVDPDTGIIDRKEPLETLK Q922Q1 amidoxime reducing 5 2721.603 3.88 K16(HeavyDimethyl); component 2 K23(HeavyDimethyl) C1(Carbamidomethyl); K7(Dimethyl); CVNAEGKLDHHMNSVLIQQEILVLKR Q62386 Interleukin-17A 1 3116.681 3.32 M12(Oxidation); K25(Dimethyl) N-Term(Dimethyl); Dehydrogenase/reductas CVPVVCDSSQESEVK Q99L04 C1(Carbamidomethyl); 10 1778.822 3.69 e SDR family member 1 C6(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dehydrogenase/reductas C1(Carbamidomethyl); CVPVVCDSSQESEVK Q99L04 7 1794.912 3.85 e SDR family member 1 C6(Carbamidomethyl); K15(HeavyDimethyl) N-Term(Dimethyl); Dehydrogenase/reductas C1(Carbamidomethyl); CVPVVCDSSQESEVKSLFEQVDREQK Q99L04 1 3166.530 2.75 e SDR family member 1 C6(Carbamidomethyl); K15(Dimethyl); K26(Dimethyl) Isoform 3 of Tyrosine- CVPYWPEVGTQRVYGLYSVTNSREHD C1(Carbamidomethyl); P29351-3 protein phosphatase non- 1 3740.811 2.64 TAEYK K31(HeavyDimethyl) receptor type 6 CVRVLEVASGSGQHAAHFAQAFPNAE N-Term(Dimethyl); G5E8X1 Protein 0610011F06Rik 1 3892.856 3.56 WQPSDVDQR C1(Carbamidomethyl) CVRVLEVASGSGQHAAHFAQAFPNAE N-Term(Dimethyl:2H(6)13C(2)); E9Q7K5 Protein 0610011F06Rik 1 3900.908 3.02 WQPSDVDQR C1(Carbamidomethyl) Glutaminase liver N-Term(Dimethyl); CVSSNIVLLTQAFR Q571F8 1 1635.883 2.33 isoform, mitochondrial C1(Carbamidomethyl) Glutaminase liver N-Term(Dimethyl:2H(6)13C(2)); CVSSNIVLLTQAFR Q571F8 2 1643.936 2.47 isoform, mitochondrial C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Dehydrogenase/reductas CVVALATDPNILNLSGK Q99L04 C1(Carbamidomethyl); 1 1857.116 3.04 e SDR family member 1 K17(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); CVVILPDSVR Q91WT9-2 Cystathionine beta- 6 1185.664 2.97 C1(Carbamidomethyl) synthase Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); CVVILPDSVR Q91WT9-2 Cystathionine beta- 8 1193.709 2.80 C1(Carbamidomethyl) synthase Rho-related GTP- N-Term(Dimethyl); CVVVGDGAVGK G3UZM2 binding protein RhoJ 2 1116.605 2.36 C1(Carbamidomethyl); K11(Dimethyl) (Fragment) N-Term(Dimethyl); Xanthine CWDECIASSQYQAR Q00519 C1(Carbamidomethyl); 1 1801.757 3.42 dehydrogenase/oxidase C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Xanthine CWDECIASSQYQAR Q00519 C1(Carbamidomethyl); 1 1809.807 2.57 dehydrogenase/oxidase C5(Carbamidomethyl) N-Term(Dimethyl); CWDEEMLDDAGK G3X982 Aldehyde oxidase 3 1 1524.632 2.25 C1(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); CWDEEMLDDAGK G3X982 Aldehyde oxidase 3 C1(Carbamidomethyl); 1 1540.726 2.26 K12(HeavyDimethyl) N-Term(Dimethyl); CWEENQYLLCPHSATAVNYHYQQTDS Threonine synthase-like Q80W22 C1(Carbamidomethyl); 1 3870.681 3.06 GQSSIR 2 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CWEENQYLLCPHSATAVNYHYQQTDS Threonine synthase-like Q80W22 C1(Carbamidomethyl); 1 3878.766 3.14 GQSSIR 2 C10(Carbamidomethyl) Homogentisate 1,2- N-Term(Dimethyl:2H(6)13C(2)); CWEPLRSHFTPNSR O09173 3 1822.912 2.69 dioxygenase C1(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); CWSGNPKAYEIICQTMQENSGLVVTLP C1(Carbamidomethyl); Q8VC12 Urocanate hydratase 2 4881.497 3.82 HEVADEQVLQQALRP K7(HeavyDimethyl); C13(Carbamidomethyl) 3-hydroxyisobutyrate CWSSDTYNPVPGVMHGVPSSNNYQG N-Term(Dimethyl); Q99L13 dehydrogenase, 1 3715.700 4.71 GFGTTLMAK C1(Carbamidomethyl); K34(Dimethyl) mitochondrial 3-hydroxyisobutyrate N-Term(Dimethyl:2H(6)13C(2)); CWSSDTYNPVPGVMHGVPSSNNYQG Q99L13 dehydrogenase, C1(Carbamidomethyl); 3 3731.790 6.04 GFGTTLMAK mitochondrial K34(HeavyDimethyl) 3-hydroxyisobutyrate N-Term(Dimethyl:2H(6)13C(2)); CWSSDTYNPVPGVMHGVPSSNNYQG Q99L13 dehydrogenase, C1(Carbamidomethyl); M14(Oxidation); 1 3747.777 2.90 GFGTTLMAK mitochondrial K34(HeavyDimethyl)

3-hydroxyisobutyrate N-Term(Dimethyl:2H(6)13C(2)); CWSSDTYNPVPGVMHGVPSSNNYQG Q99L13 dehydrogenase, C1(Carbamidomethyl); M32(Oxidation); 2 3747.794 3.22 GFGTTLMAK mitochondrial K34(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); CYEMASHLR P62962 Profilin-1 2 1202.580 2.44 C1(Carbamidomethyl) Carbamoyl-phosphate N-Term(Dimethyl); DADPILRCEMASTGEVACFGEGIHTAF Q8C196 synthase [ammonia], C8(Carbamidomethyl); 2 3251.544 4.34 LK mitochondrial C18(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate DADPILRCEMASTGEVACFGEGIHTAF C8(Carbamidomethyl); Q8C196 synthase [ammonia], 4 3267.649 4.84 LK C18(Carbamidomethyl); mitochondrial K29(HeavyDimethyl) N-Term(Dimethyl); 3-ketoacyl-CoA thiolase, DAEVVLCGGTESMSQSPYCVR Q8BWT1 C7(Carbamidomethyl); 12 2373.050 6.66 mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl); 3-ketoacyl-CoA thiolase, DAEVVLCGGTESMSQSPYCVR Q8BWT1 C7(Carbamidomethyl); M13(Oxidation); 1 2389.039 5.31 mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, DAEVVLCGGTESMSQSPYCVR Q8BWT1 C7(Carbamidomethyl); 7 2381.084 6.86 mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, DAEVVLCGGTESMSQSPYCVR Q8BWT1 C7(Carbamidomethyl); M13(Oxidation); 2 2397.087 5.78 mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, DAEVVLCGGTESMSQSPYCVRNVR Q8BWT1 C7(Carbamidomethyl); 1 2750.316 3.08 mitochondrial C19(Carbamidomethyl) N-Term(Dimethyl); DAGCPVFLYEFQHTPSSFAK Q8VCU1 Carboxylesterase 3B 7 2357.127 3.59 C4(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DAGCPVFLYEFQHTPSSFAK Q8VCU1 Carboxylesterase 3B C4(Carbamidomethyl); 2 2373.249 2.66 K20(HeavyDimethyl) Phosphoglycerate N-Term(Dimethyl); K3(Dimethyl); DAKIEFDICYTSVLKR O70250 2 2042.079 2.57 mutase 2 C9(Carbamidomethyl); K15(Dimethyl) Down syndrome cell DAKSLAEMLMSKNTR Q9ERC8 adhesion molecule K3(Dimethyl); K12(Dimethyl) 1 1750.926 2.41 homolog DANAYNFIMALPQQFDTLVGEGGGQM N-Term(Dimethyl:2H(6)13C(2)); J3QNY6 Bile salt export pump 1 3616.830 2.97 SGGQKQR M26(Oxidation); K31(HeavyDimethyl) N-Term(Dimethyl); DASINPPMCLQDVEK Q8VCU1 Carboxylesterase 3B 1 1772.832 2.83 C9(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl); M8(Oxidation); DASINPPMCLQDVEK Q8VCU1 Carboxylesterase 3B 1 1788.833 2.36 C9(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DASINPPMCLQDVEK Q8VCU1 Carboxylesterase 3B C9(Carbamidomethyl); 3 1788.945 2.98 K15(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); DASINPPMCLQDVER Q63880-2 18 1772.820 4.29 Carboxylesterase 3A C9(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); M8(Oxidation); DASINPPMCLQDVER Q63880-2 16 1788.817 3.52 Carboxylesterase 3A C9(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); DASINPPMCLQDVER Q63880-2 16 1780.863 4.63 Carboxylesterase 3A C9(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); DASINPPMCLQDVER Q63880-2 15 1796.861 3.23 Carboxylesterase 3A M8(Oxidation); C9(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); DASINPPMCLQDVERMSNSR Q63880-2 1 2356.121 2.50 Carboxylesterase 3A C9(Carbamidomethyl) DASPGRGSHSQSSSPGALTLGR O88935-1 Isoform Ib of Synapsin-1 N-Term(Dimethyl:2H(6)13C(2)) 1 2161.144 2.82 N-Term(Dimethyl); K13(Dimethyl); DAVSNTTNQLESKQSAELNK Q61595-2 Isoform 2 of Kinectin 1 2261.162 2.39 K20(Dimethyl) N-Term(Dimethyl); DCELLLQECIQQTTK Q99J08 SEC14-like protein 2 C2(Carbamidomethyl); 5 1934.956 3.49 C9(Carbamidomethyl); K15(Dimethyl) Mitochondrial N-Term(Dimethyl); DCGDEVAQWFTNYLK Q922Q1 amidoxime reducing 4 1901.874 3.34 C2(Carbamidomethyl); K15(Dimethyl) component 2 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); DCGDEVAQWFTNYLK Q922Q1 amidoxime reducing C2(Carbamidomethyl); 6 1917.957 4.02 component 2 K15(HeavyDimethyl) Mitochondrial N-Term(Dimethyl); DCGDEVAQWFTNYLKTQAYR Q922Q1 amidoxime reducing 1 2521.190 3.01 C2(Carbamidomethyl); K15(Dimethyl) component 2 Mitochondrial N-Term(Dimethyl); DCGEDAAQWVSSFLK Q9CW42 amidoxime-reducing 7 1768.820 4.38 C2(Carbamidomethyl); K15(Dimethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); DCGEDAAQWVSSFLK Q9CW42 amidoxime-reducing C2(Carbamidomethyl); 4 1784.918 4.16 component 1 K15(HeavyDimethyl) Isoamyl acetate- N-Term(Dimethyl); DCGTDVLDLWTLMQK Q9DB29 hydrolyzing esterase 1 1 1850.905 2.64 C2(Carbamidomethyl); K15(Dimethyl) homolog N-Term(Dimethyl); DCLFASQSGSQPR P27046 Alpha-mannosidase 2 2 1480.680 2.70 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DCLFASQSGSQPR P27046 Alpha-mannosidase 2 1 1488.732 2.39 C2(Carbamidomethyl) 3-ketoacyl-CoA thiolase N-Term(Dimethyl); DCLIPMGITSENVAER Q8VCH0 1 1832.884 2.75 B, peroxisomal C2(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl); DCLIPMGITSENVAER Q8VCH0 1 1848.875 2.28 B, peroxisomal C2(Carbamidomethyl); M6(Oxidation)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); DCLIPMGITSENVAER Q8VCH0 6 1840.934 3.40 B, peroxisomal C2(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); DCLIPMGITSENVAER Q8VCH0 1 1856.935 2.05 B, peroxisomal C2(Carbamidomethyl); M6(Oxidation)

3-ketoacyl-CoA thiolase N-Term(Dimethyl); DCLIPMGITSENVAERFGVSR Q8VCH0 3 2379.187 2.65 B, peroxisomal C2(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); DCLIPMGITSENVAERFGVSR Q8VCH0 1 2387.225 2.69 B, peroxisomal C2(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl); DCLTPMGMTSENVAER Q921H8 1 1838.799 2.25 A, peroxisomal C2(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); DCLTPMGMTSENVAER Q921H8 1 1846.849 3.04 A, peroxisomal C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DCMLGMEFSGR P19096 Fatty acid synthase 1 1338.602 2.00 C2(Carbamidomethyl) Zinc-binding alcohol N-Term(Dimethyl:2H(6)13C(2)); DCPVPLPGDGDLLVR Q8BGC4 dehydrogenase domain- 1 1658.888 2.49 C2(Carbamidomethyl) containing protein 2 N-Term(Dimethyl); Phosphoglycerate kinase DCVGPEVENACANPAAGTVILLENLR P09411 C2(Carbamidomethyl); 2 2810.397 4.06 1 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Phosphoglycerate kinase DCVGPEVENACANPAAGTVILLENLR P09411 C2(Carbamidomethyl); 1 2818.460 2.75 1 C11(Carbamidomethyl) DDGLRRRPHLNISMPHDFRPVSSIIDVD Partitioning defective 6 Q9JK84 N-Term(Dimethyl:2H(6)13C(2)) 1 4140.147 3.44 ILPETHR homolog gamma Myosin light chain N-Term(Dimethyl); DDLGVYTCMVVNGSGK Q6PDN3 1 1770.837 2.15 kinase, smooth muscle C8(Carbamidomethyl); K16(Dimethyl) DDLGVYTCMVVNGSGKASMSAELSIP Myosin light chain Q6PDN3 C8(Carbamidomethyl); K16(Dimethyl) 1 3881.971 3.40 GLDNASRLAVR kinase, smooth muscle Rho guanine nucleotide DDPQLYQEIRERGLNTSH B1ASH7 exchange factor 16 2 2171.080 2.51 (Fragment) Mirror-image DEAIAHVKHMEMSLKMLENINPEEND K8(Dimethyl); M12(Oxidation); E9Q8Z7 polydactyly gene 1 1 4224.041 3.01 MTLQELLNR K15(Dimethyl); M16(Oxidation) protein homolog Glycerol-3-phosphate DEDAVQFANRVKSAIAR Q8K2C8 N-Term(Dimethyl); K12(Dimethyl) 1 1946.032 2.25 acyltransferase 4 N-Term(Dimethyl:2H(6)13C(2)); DEGVYTCSATNLAGESK A2AJ76 Hemicentin-2 C7(Carbamidomethyl); 1 1873.945 2.16 K17(HeavyDimethyl) Serine-rich coiled-coil K13(HeavyDimethyl); DELISQLQAELEKVQHLQKAFASR F7CDW2 domain-containing 3 2853.614 2.45 K19(HeavyDimethyl) protein 1 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); DEMEEWSASEAMLFEEALEKYGKDFN Metastasis-associated M3(Oxidation); M12(Oxidation); Q9R190 1 3622.795 3.04 DIR protein MTA2 K20(HeavyDimethyl); K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C9(Carbamidomethyl); DEQELEPTCEFCGSDLRSLFFKMDTSS C12(Carbamidomethyl); D3Z6S9 Glutamate-rich protein 6 1 4311.149 3.38 ENIQTKPK K22(HeavyDimethyl); K33(HeavyDimethyl); K35(HeavyDimethyl) Isoform 2 of CWF19- N-Term(Dimethyl); K12(Dimethyl); DEWMTIDFMSIKTVSSSSLKAEK Q8BG79-2 1 2745.375 2.94 like protein 2 K20(Dimethyl); K23(Dimethyl) Death ligand signal K7(Dimethyl); K17(Dimethyl); DFASQAKAAEAHPPGGKNEQDK Q9DCV6 1 2380.211 2.23 enhancer K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytoplasmic aconitate DFESCLGAK P28271 C5(Carbamidomethyl); 1 1098.602 1.99 hydratase K9(HeavyDimethyl) N-Term(Dimethyl); DFIDCFLTK P33267 Cytochrome P450 2F2 2 1214.612 2.68 C5(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DFIDCFLTK P33267 Cytochrome P450 2F2 C5(Carbamidomethyl); 6 1230.704 2.65 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); DFMCELCGKTFSERNTMETHK E9Q6A1 Protein Prdm15 C7(Carbamidomethyl); 1 2729.343 2.86 K9(HeavyDimethyl); K21(HeavyDimethyl) UDP- N-Term(Dimethyl); DFNLDGAPYGYTPFCDSR Q6P5E4 glucose:glycoprotein 1 2122.922 3.39 C15(Carbamidomethyl) glucosyltransferase 1 UDP- N-Term(Dimethyl:2H(6)13C(2)); DFNLDGAPYGYTPFCDSR Q6P5E4 glucose:glycoprotein 1 2130.955 2.66 C15(Carbamidomethyl) glucosyltransferase 1 N-Term(Dimethyl); DFTPVCTTELGR O08709 Peroxiredoxin-6 8 1423.687 2.87 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DFTPVCTTELGR O08709 Peroxiredoxin-6 5 1431.731 2.48 C6(Carbamidomethyl) Glutamate DGDGIFSPGGAISNMYSIMAARYK P48318 M15(Oxidation); K24(HeavyDimethyl) 1 2573.282 2.75 decarboxylase 1 DGFRPSRSIIFASWTAGDFGAVGATEW Transferrin receptor Q8C872 K38(HeavyDimethyl) 1 4178.169 2.66 LEGYLSSLHLK protein 1 K16(HeavyDimethyl); DGGLESDVIDESGIPKETTSATEKDISR E9Q0T8 Protein Dnah7a 1 3021.554 2.61 K24(HeavyDimethyl) Trifunctional enzyme DGGQYALVAACAAGGQGHAMIVEAY N-Term(Dimethyl); Q99JY0 subunit beta, 3 2761.380 5.42 PK C11(Carbamidomethyl); K27(Dimethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl); DGGQYALVAACAAGGQGHAMIVEAY Q99JY0 subunit beta, C11(Carbamidomethyl); 1 2777.343 2.80 PK mitochondrial M20(Oxidation); K27(Dimethyl) Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); DGGQYALVAACAAGGQGHAMIVEAY Q99JY0 subunit beta, C11(Carbamidomethyl); 1 2777.424 3.43 PK mitochondrial K27(HeavyDimethyl) K3(Dimethyl); K16(Dimethyl); DGKNNVAFMSYFLQGKLDACLELLIR O55029 Coatomer subunit beta' 1 3071.604 2.94 C20(Carbamidomethyl) Isoform 2 of Rod cGMP- N-Term(Dimethyl:2H(6)13C(2)); DGKPFDDQDEVLMESLTQFLGWSVLN specific 3',5'-cyclic P23440-2 K3(HeavyDimethyl); 1 3814.885 3.02 TDTYDK phosphodiesterase K32(HeavyDimethyl) subunit beta DGPMCMHDNQGGAPNYYPNSFSAPE M4(Oxidation); C5(Carbamidomethyl); P24270 Catalase 2 3200.277 2.99 QQR M6(Oxidation) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl); P24270 Catalase 9 3196.327 5.05 QQR C5(Carbamidomethyl) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl); P24270 Catalase 13 3212.324 4.78 QQR C5(Carbamidomethyl); M6(Oxidation) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl); M4(Oxidation); P24270 Catalase 7 3212.321 4.39 QQR C5(Carbamidomethyl) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl); M4(Oxidation); P24270 Catalase 5 3228.317 4.08 QQR C5(Carbamidomethyl); M6(Oxidation) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 12 3204.371 5.40 QQR C5(Carbamidomethyl) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 9 3220.371 4.40 QQR C5(Carbamidomethyl); M6(Oxidation) DGPMCMHDNQGGAPNYYPNSFSAPE N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 10 3220.352 4.37 QQR M4(Oxidation); C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DGPMCMHDNQGGAPNYYPNSFSAPE P24270 Catalase M4(Oxidation); C5(Carbamidomethyl); 1 3236.365 2.88 QQR M6(Oxidation) Collagen alpha-2(I) DGRSGQPGPVGPAGVR Q01149 N-Term(Dimethyl) 1 1534.799 2.08 chain Kinesin-like protein K5(Dimethyl); K7(Dimethyl); DGSAKQKAMLDVHK Q6P9P6 1 1627.894 2.18 KIF11 M9(Oxidation); K14(Dimethyl) Elongation factor 1- N-Term(Dimethyl); DGSASGTTLLEALDCILPPTRPTDKPLR P10126 1 3050.642 3.19 alpha 1 C15(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Elongation factor 1- DGSASGTTLLEALDCILPPTRPTDKPLR P10126 C15(Carbamidomethyl); 1 3066.726 2.89 alpha 1 K25(HeavyDimethyl) N-Term(Dimethyl); DGSASGTTLLEALDCILPPTRPTDKPLR Elongation factor 1- P10126 C15(Carbamidomethyl); K25(Dimethyl); 7 4035.180 4.01 LPLQDVYK alpha 1 K36(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DGSASGTTLLEALDCILPPTRPTDKPLR Elongation factor 1- C15(Carbamidomethyl); P10126 5 4059.306 3.69 LPLQDVYK alpha 1 K25(HeavyDimethyl); K36(HeavyDimethyl) Isoform 3 of Neutral N-Term(Dimethyl); DGSDYEGWCWPGSASYPDFTNPR Q8BHN3-3 7 2692.100 4.77 alpha-glucosidase AB C9(Carbamidomethyl) Isoform 3 of Neutral N-Term(Dimethyl:2H(6)13C(2)); DGSDYEGWCWPGSASYPDFTNPR Q8BHN3-3 3 2700.150 4.69 alpha-glucosidase AB C9(Carbamidomethyl) Ubiquitin carboxyl- M5(Oxidation); M15(Oxidation); DGSGMYELFAFISHMGTSTMSGHYVC F6ZE47 terminal hydrolase 13 C26(Carbamidomethyl); K29(Dimethyl); 1 3821.784 3.10 HIKKEGR (Fragment) K30(Dimethyl) K6(Dimethyl); M20(Oxidation); DGSSAKEWEVYNFPAGGVGMGMYNT Isocitrate dehydrogenase M22(Oxidation); P54071 1 4996.282 2.96 DESISGFAHSCFQYSIQKK [NADP], mitochondrial C36(Carbamidomethyl); K43(Dimethyl); K44(Dimethyl) Calcium-binding N-Term(Dimethyl:2H(6)13C(2)); DGSVPLLAEIFAGGCAGGSQVIFTNPLE Q9QXX4 mitochondrial carrier C15(Carbamidomethyl); 2 3231.754 3.26 IVK protein Aralar2 K31(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); DGTAHPAMCLQNLDMLNEAGLPDMK Q91WG0 Acylcarnitine hydrolase C9(Carbamidomethyl); 2 2814.394 3.01 K25(HeavyDimethyl) Pyrethroid hydrolase N-Term(Dimethyl); DGTSHPNMCLQNDNLMGSEDLK Q8BK48 4 2532.107 3.75 Ces2e C9(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl); Pyrethroid hydrolase DGTSHPNMCLQNDNLMGSEDLK Q8BK48 C9(Carbamidomethyl); M16(Oxidation); 1 2548.102 3.16 Ces2e K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Pyrethroid hydrolase DGTSHPNMCLQNDNLMGSEDLK Q8BK48 C9(Carbamidomethyl); 1 2548.203 2.67 Ces2e K22(HeavyDimethyl) Isoform 2 of Pyrethroid N-Term(Dimethyl); DGTSQPAMCLQPDIMNLEDAK Q8QZR3-2 5 2390.103 4.65 hydrolase Ces2a C9(Carbamidomethyl); K21(Dimethyl)

Isoform 2 of Pyrethroid N-Term(Dimethyl); M8(Oxidation); DGTSQPAMCLQPDIMNLEDAK Q8QZR3-2 1 2406.099 3.12 hydrolase Ces2a C9(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Pyrethroid DGTSQPAMCLQPDIMNLEDAK Q8QZR3-2 C9(Carbamidomethyl); 1 2406.195 3.42 hydrolase Ces2a K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Pyrethroid DGTSQPAMCLQPDIMNLEDAK Q8QZR3-2 M8(Oxidation); C9(Carbamidomethyl); 1 2422.202 4.14 hydrolase Ces2a K21(HeavyDimethyl) Acyl-coenzyme A N-Term(Dimethyl); DGVLAVTCAQEGVIR P58137 1 1615.849 2.42 thioesterase 8 C8(Carbamidomethyl) Isoform 2 of NADH- N-Term(Dimethyl:2H(6)13C(2)); DHLPTPGEEPLILMCGPPPMIQFACLPN Q9DCN2-2 cytochrome b5 reductase C15(Carbamidomethyl); 1 3578.813 5.68 LER 3 C25(Carbamidomethyl) Insulin-like growth DHSGVQRTELLPGDRENLAIQTR Q61581 N-Term(Dimethyl:2H(6)13C(2)) 1 2641.417 2.61 factor-binding protein 7 4- N-Term(Dimethyl); DIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate 8 1873.905 4.21 C9(Carbamidomethyl); K15(Dimethyl) dioxygenase 4- N-Term(Dimethyl:2H(6)13C(2)); DIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate C9(Carbamidomethyl); 5 1889.993 4.52 dioxygenase K15(HeavyDimethyl) Isoform Short of N-Term(Dimethyl); DICEGQVNSLPGSINK P01027-2 1 1786.892 2.33 Complement C3 C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of DICEGQVNSLPGSINK P01027-2 C3(Carbamidomethyl); 1 1802.982 2.63 Complement C3 K16(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); DICQSFTNLSK Q91X77-2 8 1368.681 3.34 Cytochrome P450 2C50 C3(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of DICQSFTNLSK Q91X77-2 C3(Carbamidomethyl); 2 1384.770 2.25 Cytochrome P450 2C50 K11(HeavyDimethyl) N-Term(Dimethyl); DICQSFTNLSR Q6XVG2 Cytochrome P450 2C54 6 1368.657 3.22 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DICQSFTNLSR Q6XVG2 Cytochrome P450 2C54 6 1376.698 2.52 C3(Carbamidomethyl) Cytochrome b-c1 N-Term(Dimethyl); DICSKYFYDQCPAVAGYGPIEQLPDYN Q9CZ13 complex subunit 1, C3(Carbamidomethyl); K5(Dimethyl); 1 3395.559 3.57 R mitochondrial C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytochrome b-c1 DICSKYFYDQCPAVAGYGPIEQLPDYN C3(Carbamidomethyl); Q9CZ13 complex subunit 1, 1 3411.667 3.57 R K5(HeavyDimethyl); mitochondrial C11(Carbamidomethyl) Cytochrome b-c1 N-Term(Dimethyl); DICSKYFYDQCPAVAGYGPIEQLPDYN Q9CZ13 complex subunit 1, C3(Carbamidomethyl); K5(Dimethyl); 1 3664.763 3.69 RIR mitochondrial C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytochrome b-c1 DICSKYFYDQCPAVAGYGPIEQLPDYN C3(Carbamidomethyl); Q9CZ13 complex subunit 1, 1 3680.870 4.25 RIR K5(HeavyDimethyl); mitochondrial C11(Carbamidomethyl) DIESLMSEGNKSR E9Q4K7 Protein Kif13b K11(HeavyDimethyl) 1 1501.761 2.16 Actin, gamma-enteric N-Term(Dimethyl); K3(Dimethyl); DIKEKLCYVALDFENEMATAASSSSLE D3YZY0 smooth muscle K5(Dimethyl); C7(Carbamidomethyl); 1 3277.647 3.97 K (Fragment) M17(Oxidation); K28(Dimethyl) N-Term(Dimethyl); K3(Dimethyl); DIKEKLCYVALDFEQEMATAASSSSLE E9Q1F2 Actin, cytoplasmic 1 K5(Dimethyl); C7(Carbamidomethyl); 4 3275.654 3.93 K K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); DIKEKLCYVALDFEQEMATAASSSSLE E9Q1F2 Actin, cytoplasmic 1 K5(HeavyDimethyl); 2 3307.817 4.78 K C7(Carbamidomethyl); K28(HeavyDimethyl) Calcium-binding N-Term(Dimethyl:2H(6)13C(2)); DIMVTIRPHVLTPFVEECLVAAAGGTR Q9QXX4 mitochondrial carrier 1 2988.634 3.08 C18(Carbamidomethyl) protein Aralar2 Calcium-binding N-Term(Dimethyl); DIPFSAIYFPCYAHVK Q9QXX4 mitochondrial carrier 1 1983.993 2.75 C11(Carbamidomethyl); K16(Dimethyl) protein Aralar2 Calcium-binding N-Term(Dimethyl:2H(6)13C(2)); DIPFSAIYFPCYAHVK Q9QXX4 mitochondrial carrier C11(Carbamidomethyl); 1 2000.089 2.90 protein Aralar2 K16(HeavyDimethyl) Calcium-binding N-Term(Dimethyl); DIPFSAIYFPVYAHCK Q8BH59 mitochondrial carrier 1 1984.019 2.58 C15(Carbamidomethyl); K16(Dimethyl) protein Aralar1 N-Term(Dimethyl:2H(6)13C(2)); DIQSMTYLADMNWDAVFEKALMPGF Serine/threonine-protein M5(Oxidation); M11(Oxidation); Q9JJX8 1 3684.965 3.05 VPNKGR kinase 32B K19(HeavyDimethyl); K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aldo-keto reductase DIVLVAYCALGSQRPK G3X9Y6 C8(Carbamidomethyl); 1 1862.116 2.16 family 1, member C19 K16(HeavyDimethyl) DKAQRKPETQHR O70551 SRSF protein kinase 1 K2(Dimethyl); K6(Dimethyl) 1 1549.860 2.46 Isoform 3 of ATP- N-Term(Dimethyl); K2(Dimethyl); DKEDDGGEDDDANCNLICGDEYGPET O70133-3 dependent RNA helicase C14(Carbamidomethyl); 1 3115.258 2.98 K A C18(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 3 of ATP- K2(HeavyDimethyl); DKEDDGGEDDDANCNLICGDEYGPET O70133-3 dependent RNA helicase C14(Carbamidomethyl); 1 3139.390 4.45 K A C18(Carbamidomethyl); K27(HeavyDimethyl) Isoform 3 of DNA- directed RNA K2(Dimethyl); C6(Carbamidomethyl); DKLDSCIEAFGSTKQK Q8K202-3 2 1910.965 2.42 polymerase I subunit K14(Dimethyl); K16(Dimethyl) RPA49 Ubiquitin-conjugating DKQPQPAAGAAGAAGAGGPR E9QMD2 enzyme E2Q-like protein N-Term(Dimethyl); K2(Dimethyl) 1 1803.937 2.56 1 Transcription factor N-Term(Dimethyl); K2(Dimethyl); DKSLGAEMDSVRSWVR O08792 1 1907.954 2.41 COE2 M8(Oxidation) HRAS-like suppressor 3 N-Term(Dimethyl); K2(Dimethyl); DKYQVNNKHDEEYTPLPLSK D3YYG1 1 2530.302 2.81 (Fragment) K8(Dimethyl); K20(Dimethyl) Isocitrate dehydrogenase N-Term(Dimethyl); DLAACIKGLPNVQR O88844 2 1610.902 2.52 [NADP] cytoplasmic C5(Carbamidomethyl); K7(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase DLAGCIHGLSNVK P54071 C5(Carbamidomethyl); 2 1455.855 2.73 [NADP], mitochondrial K13(HeavyDimethyl) Aldehyde DLDKANYLSQALQAGTVWINCYDVFG N-Term(Dimethyl); K4(Dimethyl); P47738 dehydrogenase, 8 3980.978 6.70 AQSPFGGYK C21(Carbamidomethyl); K35(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Aldehyde DLDKANYLSQALQAGTVWINCYDVFG K4(HeavyDimethyl); P47738 dehydrogenase, 6 4005.108 6.80 AQSPFGGYK C21(Carbamidomethyl); mitochondrial K35(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aldehyde DLDKANYLSQALQAGTVWINCYDVFG K4(HeavyDimethyl); P47738 dehydrogenase, 1 4580.353 3.82 AQSPFGGYKMSGSGR C21(Carbamidomethyl); mitochondrial K35(HeavyDimethyl) Methylthioribose-1- DLGQVAAQEAEREGATEETVRER F8WI95 phosphate isomerase N-Term(Dimethyl:2H(6)13C(2)) 1 2580.270 2.30 (Fragment) Isoform 2 of Glycerol-3- DLGVLQEMPSPTGPQLHLSPTFATRDN phosphate N-Term(Dimethyl); M8(Oxidation); Q14DK4-2 1 4151.136 3.50 QDKLEQFIR acyltransferase 2, K30(Dimethyl) mitochondrial 3 beta-hydroxysteroid N-Term(Dimethyl:2H(6)13C(2)); DLGYEPLVNWEEAK A2AEP8 dehydrogenase/Delta 5-- 1 1734.948 2.08 K14(HeavyDimethyl) >4-isomerase type 1 DLLEKFRTTMLQDSIHVVINGYFPGVS Origin recognition K5(HeavyDimethyl); M10(Oxidation); Q59IX1 1 3394.910 2.88 VK complex subunit 2 K29(HeavyDimethyl) Isoform 3 of Chondroitin DLLFGSIVAMEEPTRPIYR Q8VHY0-3 N-Term(Dimethyl) 1 2235.182 2.78 sulfate proteoglycan 4 Mitochondrial N-Term(Dimethyl); DLLLPITPPATNPLLQCR Q9CW42 amidoxime-reducing 1 2060.161 2.38 C17(Carbamidomethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); DLLLPITPPATNPLLQCR Q9CW42 amidoxime-reducing 5 2068.208 2.95 C17(Carbamidomethyl) component 1 DLLQPEVAVALLEAQAGTGHIIDPATS F6R059 Plectin (Fragment) N-Term(Dimethyl) 1 2984.587 2.73 AR N-Term(Dimethyl:2H(6)13C(2)); DLMACAQTGSGKTAAFLLPILSQIYAD ATP-dependent RNA Q62167 C5(Carbamidomethyl); 1 3607.966 3.29 GPGEALR helicase DDX3X K12(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); DLTTAGAVTQCYR P62717 7 1483.718 3.49 L18a C11(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); DLTTAGAVTQCYR P62717 1 1491.776 2.90 L18a C11(Carbamidomethyl) Dehydrogenase/reductas N-Term(Dimethyl); DMFNVNVLALSICTREAYQSMKER Q3U0B3 e SDR family member 1 2931.438 2.37 C13(Carbamidomethyl); K22(Dimethyl) 11 N-Term(Dimethyl); DMHGDSEYNIMFGPDICGPGTK P14211 Calreticulin 1 2497.066 2.81 C17(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DMHGDSEYNIMFGPDICGPGTK P14211 Calreticulin C17(Carbamidomethyl); 1 2513.175 4.88 K22(HeavyDimethyl) N-Term(Dimethyl); DMHGDSEYNIMFGPDICGPGTKK P14211 Calreticulin C17(Carbamidomethyl); K22(Dimethyl); 2 2653.199 2.74 K23(Dimethyl) 60S ribosomal protein N-Term(Dimethyl); DMIREVCGFAPYER P47964 2 1770.828 2.67 L36 C7(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); DMIREVCGFAPYER P47964 1 1778.877 2.56 L36 C7(Carbamidomethyl) Leucine-rich repeat and N-Term(Dimethyl); M7(Oxidation); DMRAVPMEMFNYCSQLEDENNSAGL Q8BGX3 transmembrane domain- M9(Oxidation); C13(Carbamidomethyl); 1 3932.651 2.75 DAPGPPCTK containing protein 2 C32(Carbamidomethyl); K34(Dimethyl)

Transmembrane protein K8(HeavyDimethyl); DNAIRPGKDGQEGRTSHLQK Q8CEF9 1 2279.251 2.38 132C K20(HeavyDimethyl) Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)); DNIEEALLLLLISESMATR D3Z0R8 1 2183.185 2.17 protein 7A M16(Oxidation) Ubiquitin-like modifier- N-Term(Dimethyl:2H(6)13C(2)); DNPGVVTCLDEAR Q02053 5 1481.739 2.33 activating enzyme 1 C8(Carbamidomethyl) Deoxyribonuclease-1- DPDLSAVSLLMEQINR Q9D1G0 M11(Oxidation) 2 1816.891 2.25 like 2 Serine/threonine-protein N-Term(Dimethyl); K10(Dimethyl); DPEIAELFFKEDPEKLFTDLR Q5F2E8 1 2636.372 2.71 kinase TAO1 K15(Dimethyl) Sarcosine N-Term(Dimethyl:2H(6)13C(2)); DPLHEELLGQGCVFQER Q99LB7 dehydrogenase, 1 2063.054 2.47 C12(Carbamidomethyl) mitochondrial Cell adhesion molecule- related/down-regulated DPQDGSESSLLNLFPVK F6SDC3 K17(Dimethyl) 1 1873.945 2.35 by oncogenes (Fragment) Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)); DPSQSTSTTEAPEGPRPSK Q3V0B6 1 2044.052 2.32 protein 16 K19(HeavyDimethyl) DPVAAGTGRQDPENQCILEKSNHLVSQ C2 domain-containing C16(Carbamidomethyl); V9GXB2 1 3920.938 2.90 VSSLISGDY protein 3 (Fragment) K20(HeavyDimethyl) DPVLYIYQLLDNYK J3KML6 Protein Gm20830 N-Term(Dimethyl); K14(Dimethyl) 2 1812.957 2.43 N-Term(Dimethyl:2H(6)13C(2)); DQALAEQCLSALTQCAASGDGNILALA Methylmalonyl-CoA P16332 C8(Carbamidomethyl); 3 3309.671 4.62 VDAAR mutase, mitochondrial C15(Carbamidomethyl) Cystathionine beta- N-Term(Dimethyl); DQAWSGVVGGPTDCSNGMSSK Q91WT9 1 2195.974 4.13 synthase C14(Carbamidomethyl); K21(Dimethyl)

DQDAAPPGAAAFYAPGPLPPGRGSEH Myoblast determination P10085 N-Term(Dimethyl:2H(6)13C(2)) 1 3704.786 2.77 YSGDSDASSPR protein 1 N-Term(Dimethyl:2H(6)13C(2)); Threonine--tRNA ligase, DQELYFFHELSPGSCFFLPK Q9D0R2 C15(Carbamidomethyl); 1 2533.298 2.71 cytoplasmic K20(HeavyDimethyl) DQLLELIGDVVFGVPSVIVSRGHR H3BL34 Carboxylesterase 1E N-Term(Dimethyl:2H(6)13C(2)) 1 2641.485 2.60 DQRGPYPPEVAGMGMRPHGFRFGFPG Histone-lysine N- N-Term(Dimethyl:2H(6)13C(2)); Q8BRH4 1 4045.883 2.62 AGHGPMPSQDR methyltransferase 2C M32(Oxidation) N-Term(Dimethyl); DQTCTPVPVK Q9EQF5 Dihydropyrimidinase 2 1200.630 2.51 C4(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DQTCTPVPVK Q9EQF5 Dihydropyrimidinase C4(Carbamidomethyl); 5 1216.714 2.49 K10(HeavyDimethyl) N-Term(Dimethyl); DQTCTPVPVKR Q9EQF5 Dihydropyrimidinase 1 1356.731 2.25 C4(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DQTCTPVPVKR Q9EQF5 Dihydropyrimidinase C4(Carbamidomethyl); 1 1372.819 2.06 K10(HeavyDimethyl) N-Term(Dimethyl); DRCFATQVYCK D3Z4U1 Uricase C3(Carbamidomethyl); 2 1503.709 2.30 C10(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); DRCFATQVYCK D3Z4U1 Uricase 1 1519.795 2.61 C10(Carbamidomethyl); K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); DRLLLATMEALNGGKVFANAYLSDLG K15(HeavyDimethyl); P24549 Retinal dehydrogenase 1 1 3318.922 2.87 GCIK C28(Carbamidomethyl); K30(HeavyDimethyl) DRMQSPGGVSLATEDSIQLPGGVPLSS E9Q6E9 Protein Simc1 M3(Oxidation); K41(Dimethyl) 1 4138.056 3.03 DVIQSQGGVPLSSK M5(Oxidation); K9(HeavyDimethyl); DRNTMLANKECQAALEVLQESPLYDC GDNF family receptor O08842 C11(Carbamidomethyl); 1 3276.631 3.06 R alpha-2 C26(Carbamidomethyl) N-Term(Dimethyl); DRTVPFCSTFAAFFTR P40142 Transketolase 2 1950.949 2.80 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DRTVPFCSTFAAFFTR P40142 Transketolase 1 1959.005 2.55 C7(Carbamidomethyl) Putative bifunctional UDP-N- K4(HeavyDimethyl); DSLKEDLQQADLVISHAGAGSCLESLE Q9D8C3 acetylglucosamine C22(Carbamidomethyl); 1 3085.630 2.85 K transferase and K28(HeavyDimethyl) deubiquitinase ALG13 DSLLASLLDGVRASGNR G3X922 MCG115602 2 1743.917 2.45 C20(Carbamidomethyl); DSNLLAAPQGSYPLLANGVCK Q99JB6 Forkhead box protein P3 1 2224.178 2.54 K21(HeavyDimethyl) DSPRAPRTSPEQDLPAEAPTATVQPPR B2RQX9 Transporter N-Term(Dimethyl) 1 2912.495 2.57 N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); Alanine--glyoxylate C12(Carbamidomethyl); DSPVQTVRDCSCAPDCCQAKER Q3UEG6 aminotransferase 2, 1 2711.255 2.65 C16(Carbamidomethyl); mitochondrial C17(Carbamidomethyl); K20(HeavyDimethyl) 28S ribosomal protein DSQLYALDYETLTRPHSGR Q9JIK9 1 2222.072 2.26 S34, mitochondrial N-Term(Dimethyl); M6(Oxidation); DSTQLMCTDLNLLQQQARSATLRESQ Ectopic P granules Q80TA9 C7(Carbamidomethyl); M38(Oxidation); 1 4620.299 3.47 QVALDGELLETMPK protein 5 homolog K40(Dimethyl) Isoform 2 of Netrin N-Term(Dimethyl:2H(6)13C(2)); DSYHNLRLSIHDVPSSLWK Q8K1S4-2 1 2339.332 2.59 receptor UNC5A K19(HeavyDimethyl) DTAAAIEEVSGSIARNGREAR L7N241 Uncharacterized protein N-Term(Dimethyl) 1 2201.108 2.42 Nitric oxide synthase- DTAASGYGTQNIRLSRDAVK D3YV75 interacting protein K20(Dimethyl) 1 2151.137 2.42 (Fragment) DTGLNYTHLHVETPR Q8R1V2 B3gat1 protein N-Term(Dimethyl:2H(6)13C(2)) 1 1788.944 2.30 Isoform 2 of Probable phospholipid- N-Term(Dimethyl:2H(6)13C(2)); DTIALCTAESIDNLR Q9QZW0-2 2 1727.909 2.98 transporting ATPase C6(Carbamidomethyl) 11C N-Term(Dimethyl); M18(Oxidation); DTMLEQDITGRQSSINAMNEKVK E9QL23 Dystonin 2 2708.340 2.68 K21(Dimethyl); K23(Dimethyl) Mitogen-activated N-Term(Dimethyl); DVALRCLELQPQDRPPSR F8VQ72 protein kinase kinase 1 2178.140 2.64 C6(Carbamidomethyl) kinase 1 DVCVEASESSYQFGIIGNDRVSGAGLS 182 kDa tankyrase-1- N-Term(Dimethyl:2H(6)13C(2)); P58871 1 3193.604 2.64 PSR binding protein C3(Carbamidomethyl) Transitional N-Term(Dimethyl:2H(6)13C(2)); DVDLEFLAKMTNGFSGADLTEICQR Q01853 endoplasmic reticulum K9(HeavyDimethyl); 1 2902.494 3.08 ATPase C23(Carbamidomethyl) N-Term(Dimethyl); Aconitate hydratase, DVGGIVLANACGPCIGQWDRK Q99KI0 C11(Carbamidomethyl); 8 2342.179 4.47 mitochondrial C14(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, C11(Carbamidomethyl); DVGGIVLANACGPCIGQWDRK Q99KI0 2 2358.259 3.15 mitochondrial C14(Carbamidomethyl); K21(HeavyDimethyl) N-Term(Dimethyl); Aconitate hydratase, C11(Carbamidomethyl); DVGGIVLANACGPCIGQWDRKDIK Q99KI0 1 2726.411 3.00 mitochondrial C14(Carbamidomethyl); K21(Dimethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); Aconitate hydratase, DVGGIVLANACGPCIGQWDRKDIK Q99KI0 C14(Carbamidomethyl); 2 2750.544 3.18 mitochondrial K21(HeavyDimethyl); K24(HeavyDimethyl) UDP-glucose 6- N-Term(Dimethyl:2H(6)13C(2)); DVLNLVYLCEALNLPEVAR O70475 1 2237.257 2.92 dehydrogenase C9(Carbamidomethyl) N-Term(Dimethyl); DVMICPDTSLEDAK A2A815 Protein DJ-1 (Fragment) 1 1649.770 2.46 C5(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DVMICPDTSLEDAK A2A817 Protein DJ-1 (Fragment) C5(Carbamidomethyl); 2 1665.870 2.39 K14(HeavyDimethyl) N-Term(Dimethyl); DVPGDNGREEESLYAQDEVICVGQIVC G3X982 Aldehyde oxidase 3 C21(Carbamidomethyl); 1 4590.149 4.48 AVAADSYAHAQQAAK C27(Carbamidomethyl); K42(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DVPGDNGREEESLYAQDEVICVGQIVC C21(Carbamidomethyl); G3X982 Aldehyde oxidase 3 1 4606.245 3.76 AVAADSYAHAQQAAK C27(Carbamidomethyl); K42(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); DVQIGDIVTVGECRPLSK P62281 7 2042.096 4.32 S11 C13(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein DVQIGDIVTVGECRPLSK P62281 C13(Carbamidomethyl); 5 2058.182 4.15 S11 K18(HeavyDimethyl) Poly [ADP-ribose] DVQVSSEVFEFLQQVDSQRLSK Q2EMV9 N-Term(Dimethyl); K22(Dimethyl) 1 2624.369 2.29 polymerase 14 Expressed sequence N-Term(Dimethyl); DVRPITEQIAVTAGCK Q91WU0 15 1813.980 3.85 AU018778 C15(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Expressed sequence DVRPITEQIAVTAGCK Q91WU0 C15(Carbamidomethyl); 7 1830.067 3.37 AU018778 K16(HeavyDimethyl) NADPH:adrenodoxin DVSVPELREAYHAVVLSYGAEDHQPL Q61578 oxidoreductase, N-Term(Dimethyl) 1 4284.244 3.04 GIPGEELPGVVSAR mitochondrial N-Term(Dimethyl); Kynurenine 3- DVTCDLVVGCDGAYSTVR Q3V0K6 C4(Carbamidomethyl); 1 2014.915 3.13 monooxygenase C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Kynurenine 3- DVTCDLVVGCDGAYSTVR Q3V0K6 C4(Carbamidomethyl); 4 2022.960 4.30 monooxygenase C10(Carbamidomethyl) N-Term(Dimethyl); DVTDCLLIEMEKEK Q05421 Cytochrome P450 2E1 C5(Carbamidomethyl); K12(Dimethyl); 6 1806.920 3.39 K14(Dimethyl) N-Term(Dimethyl); DVTDCLLIEMEKEK Q05421 Cytochrome P450 2E1 C5(Carbamidomethyl); M10(Oxidation); 1 1822.915 2.25 K12(Dimethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); DVTDCLLIEMEKEK Q05421 Cytochrome P450 2E1 3 1831.051 2.87 K12(HeavyDimethyl); K14(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); M10(Oxidation); DVTDCLLIEMEKEK Q05421 Cytochrome P450 2E1 6 1847.045 2.93 K12(HeavyDimethyl); K14(HeavyDimethyl)

DWEESWNQWKMGCFQTLQTEAMES Dynein heavy chain 2, K10(Dimethyl); C13(Carbamidomethyl); P0C6F1 1 3877.719 3.11 MAHGLFR axonemal M22(Oxidation)

DWEESWNQWKMGCFQTLQTEAMES Dynein heavy chain 2, K10(Dimethyl); C13(Carbamidomethyl); P0C6F1 1 3877.742 3.19 MAHGLFR axonemal M25(Oxidation) DYAYSIINGIVFNLLAFLALASHCRAM Palmitoyltransferase D6RDS4 C24(Carbamidomethyl) 2 3682.881 2.93 LTDPGR ZDHHC3 Adipocyte plasma DYLLLVMEATDDGRLLEYDTVTK Q9D7N9 membrane-associated M7(Oxidation); K23(HeavyDimethyl) 1 2725.375 2.21 protein N-Term(Dimethyl); DYSEMYVTCAR Q64374 Regucalcin 2 1422.598 2.77 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DYSEMYVTCAR Q64374 Regucalcin 1 1430.648 2.28 C9(Carbamidomethyl) V-type proton ATPase N-Term(Dimethyl); EAAALGSHGSCSSEVEKETR Q9CR51 1 2161.026 2.59 subunit G 1 C11(Carbamidomethyl); K17(Dimethyl) Glutathione S- N-Term(Dimethyl:2H(6)13C(2)); EAAQMDMVNDGVEDLR P19157 1 1860.848 3.41 transferase P 1 M5(Oxidation); M7(Oxidation) Glutathione S- EAAQVDMVNDGVEDLR P46425 N-Term(Dimethyl:2H(6)13C(2)) 1 1796.867 2.15 transferase P 2 Oxygen-dependent N-Term(Dimethyl:2H(6)13C(2)); EACDQHGPDIYPK P36552 coproporphyrinogen-III C3(Carbamidomethyl); 2 1601.819 2.48 oxidase, mitochondrial K13(HeavyDimethyl) N-Term(Dimethyl); EACDTSFNVNLR Q91X52 L-xylulose reductase 2 1453.677 2.80 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EACPELDYFVAFSSVSCGR P19096 Fatty acid synthase C3(Carbamidomethyl); 1 2230.034 3.58 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EACPELDYFVAFSSVSCGRGNAGQTN P19096 Fatty acid synthase C3(Carbamidomethyl); 3 4028.767 3.66 YGFANSTMER C17(Carbamidomethyl) Ribosome-binding N-Term(Dimethyl); EAEETQNSLQAECDQYR A2AVJ7 3 2098.893 4.61 protein 1 C13(Carbamidomethyl) Ribosome-binding N-Term(Dimethyl:2H(6)13C(2)); EAEETQNSLQAECDQYR A2AVJ7 1 2106.941 4.23 protein 1 C13(Carbamidomethyl) N-Term(Dimethyl); EAESCDCLQGFQLTHSLGGGTGSGMG P99024 Tubulin beta-5 chain C5(Carbamidomethyl); 1 3367.607 3.72 TLLISK C7(Carbamidomethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EAESCDCLQGFQLTHSLGGGTGSGMG C5(Carbamidomethyl); P99024 Tubulin beta-5 chain 3 3383.676 5.84 TLLISK C7(Carbamidomethyl); K32(HeavyDimethyl) Delta-1-pyrroline-5- EAGLPPNIIQFVPADGPTFGDTVTSSEH carboxylate N-Term(Dimethyl); Q8CHT0 3 4474.230 3.29 LCGINFTGSVPTFK dehydrogenase, C30(Carbamidomethyl); K42(Dimethyl) mitochondrial Delta-1-pyrroline-5- N-Term(Dimethyl:2H(6)13C(2)); EAGLPPNIIQFVPADGPTFGDTVTSSEH carboxylate Q8CHT0 C30(Carbamidomethyl); 2 4490.339 3.72 LCGINFTGSVPTFK dehydrogenase, K42(HeavyDimethyl) mitochondrial EAGQKALEDAQIPYSAVEQACVGYVY Non-specific lipid- N-Term(Dimethyl); K5(Dimethyl); P32020 1 3703.744 5.99 GDSTSGQR transfer protein C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EAGQKALEDAQIPYSAVEQACVGYVY Non-specific lipid- P32020 K5(HeavyDimethyl); 7 3719.851 7.27 GDSTSGQR transfer protein C21(Carbamidomethyl) EAGRPSWWERAR L7N2B0 Protein Gm8220 N-Term(Dimethyl) 2 1528.785 2.43 40S ribosomal protein N-Term(Dimethyl); K10(Dimethyl); EAIEGTYIDKKCPFTGNVSIR P62281 1 2482.301 2.62 S11 K11(Dimethyl); C12(Carbamidomethyl)

Isocitrate dehydrogenase N-Term(Dimethyl); EAIICKNIPR O88844 3 1269.736 2.42 [NADP] cytoplasmic C5(Carbamidomethyl); K6(Dimethyl) N-Term(Dimethyl); EALAQCVLAEIPQQVVGYFNTYK Q8BT60 Copine-3 2 2697.404 3.81 C6(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EALAQCVLAEIPQQVVGYFNTYK Q8BT60 Copine-3 C6(Carbamidomethyl); 3 2713.479 3.78 K23(HeavyDimethyl) EALGLSPISHWQDINPALSRSNGTVLE A2AQ92 Protein Duox1 2 4208.157 3.15 ATAALYNQDLSR N-Term(Dimethyl:2H(6)13C(2)); EANHLCDAFTAQAGQPINPNPMLNK P11714 Cytochrome P450 2D9 C6(Carbamidomethyl); 2 2823.435 3.74 K25(HeavyDimethyl) N-Term(Dimethyl); EAPFTHFDPSCLFPACR P16015 Carbonic anhydrase 3 C11(Carbamidomethyl); 5 2079.927 3.07 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EAPFTHFDPSCLFPACR P16015 Carbonic anhydrase 3 C11(Carbamidomethyl); 10 2087.988 4.45 C16(Carbamidomethyl) Isoform 2 of EATGVLLSIDGEDGIIRMDLEDQQIK O55201-2 Transcription elongation K26(HeavyDimethyl) 1 2894.536 2.63 factor SPT5 Pyruvate dehydrogenase E1 component subunit N-Term(Dimethyl); K4(Dimethyl); EATKFAAAYCR P35486 4 1343.672 2.86 alpha, somatic form, C10(Carbamidomethyl) mitochondrial

Pyruvate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); E1 component subunit EATKFAAAYCR P35486 K4(HeavyDimethyl); 2 1359.762 2.59 alpha, somatic form, C10(Carbamidomethyl) mitochondrial

Glutamate--cysteine N-Term(Dimethyl); EATSVLGEHQALCTITSFPR P97494 6 2245.129 4.87 ligase catalytic subunit C13(Carbamidomethyl)

Glutamate--cysteine N-Term(Dimethyl:2H(6)13C(2)); EATSVLGEHQALCTITSFPR P97494 3 2253.170 5.18 ligase catalytic subunit C13(Carbamidomethyl)

Transitional N-Term(Dimethyl); EAVCIVLSDDTCSDEKIR Q01853 endoplasmic reticulum C4(Carbamidomethyl); 7 2166.053 5.02 ATPase C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Transitional C4(Carbamidomethyl); EAVCIVLSDDTCSDEKIR Q01853 endoplasmic reticulum 6 2182.126 4.46 C12(Carbamidomethyl); ATPase K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); EAVKAASDELSKTISPMVMDAK Q64727 Vinculin 1 2481.501 2.44 K12(HeavyDimethyl); M17(Oxidation); K22(HeavyDimethyl) G protein-regulated EAVSSGEGGSVSVRMAETVSARQPEG Q3UNH4 inducer of neurite M15(Oxidation); K31(HeavyDimethyl) 1 3203.549 3.12 MFPAK outgrowth 1 N-Term(Dimethyl); Betaine--homocysteine S- EAYNLGVRYIGGCCGFEPYHIR O35490 C13(Carbamidomethyl); 6 2659.258 3.69 methyltransferase 1 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- EAYNLGVRYIGGCCGFEPYHIR O35490 C13(Carbamidomethyl); 5 2667.285 4.36 methyltransferase 1 C14(Carbamidomethyl) Alpha-aminoadipic N-Term(Dimethyl); K16(Dimethyl); EAYPALRPEANPLTWKQLLCDLVGISR Q99K67 semialdehyde synthase, 2 3166.733 3.03 C20(Carbamidomethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); EAYPALRPEANPLTWKQLLCDLVGISR Q99K67 semialdehyde synthase, K16(HeavyDimethyl); 2 3182.806 3.24 mitochondrial C20(Carbamidomethyl)

EAYQNVLAAGCIPLTLGGDQTITYPIL Agmatinase, N-Term(Dimethyl); A2AS89 1 3444.843 3.09 QAVAK mitochondrial C11(Carbamidomethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EAYQNVLAAGCIPLTLGGDQTITYPIL Agmatinase, A2AS89 C11(Carbamidomethyl); 1 3460.969 3.07 QAVAK mitochondrial K32(HeavyDimethyl) N-Term(Dimethyl); C2(Carbamidomethyl); ECCHGDLLECADDR P07724 Serum albumin 1 1777.690 2.29 C3(Carbamidomethyl); C10(Carbamidomethyl) N-Term(Dimethyl); C2(Carbamidomethyl); ECCHGDLLECADDRAELAK P07724 Serum albumin 6 2318.015 3.15 C3(Carbamidomethyl); C10(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); ECCHGDLLECADDRAELAK P07724 Serum albumin C3(Carbamidomethyl); 2 2334.106 3.64 C10(Carbamidomethyl); K19(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl); ECDVLPDDTVSTLYNR Q8R0Y6 formyltetrahydrofolate 11 1924.894 3.74 C2(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); ECDVLPDDTVSTLYNR Q8R0Y6 formyltetrahydrofolate 3 1932.935 3.44 C2(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); ECDVLPDDTVSTLYNRFLFPEGIKGMV Q8R0Y6 formyltetrahydrofolate C2(Carbamidomethyl); 1 3641.939 2.93 QAVR dehydrogenase K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); ECLVHQSEIFADRPCLPLFMKMTKMG Vitamin D 25- F6RCB2 C15(Carbamidomethyl); 1 3919.105 3.11 GLLNSR hydroxylase (Fragment) K21(HeavyDimethyl); M22(Oxidation); K24(HeavyDimethyl); M25(Oxidation)

C2(Carbamidomethyl); Low-density lipoprotein C9(Carbamidomethyl); ECTESEFRCADQQCIPSRWVCDQENDC A2ARV4 receptor-related protein C14(Carbamidomethyl); 2 4252.617 3.01 GDNSDER 2 C21(Carbamidomethyl); C27(Carbamidomethyl) Isoform 3 of Carcinoembryonic N-Term(Dimethyl); EDAGEYQCEISNPVSVK Q925P2-3 1 1980.898 2.72 antigen-related cell C8(Carbamidomethyl); K17(Dimethyl) adhesion molecule 2 Isoform 3 of Carcinoembryonic N-Term(Dimethyl); EDAGEYQCEISNPVSVR P31809-3 1 1980.888 2.67 antigen-related cell C8(Carbamidomethyl) adhesion molecule 1 Isoform 3 of Carcinoembryonic N-Term(Dimethyl:2H(6)13C(2)); EDAGEYQCEISNPVSVR P31809-3 1 1988.942 2.72 antigen-related cell C8(Carbamidomethyl) adhesion molecule 1 EDARINTTIGSVAAQDPDAAR P97326 Cadherin-6 1 2171.080 2.36 3-ketoacyl-CoA thiolase, N-Term(Dimethyl); EDCDRYALQSQQR Q8BWT1 3 1696.765 3.41 mitochondrial C3(Carbamidomethyl)

3-ketoacyl-CoA thiolase, N-Term(Dimethyl:2H(6)13C(2)); EDCDRYALQSQQR Q8BWT1 2 1704.810 2.57 mitochondrial C3(Carbamidomethyl) Probable proline N-Term(Dimethyl); EDCTQPDYEATSR Q8VCZ9 1 1599.648 2.36 dehydrogenase 2 C3(Carbamidomethyl) Rho guanine nucleotide EDGAAMRAGVQTGDR Q8R4H2 N-Term(Dimethyl); M6(Oxidation) 1 1577.711 2.69 exchange factor 12 Estradiol 17 beta- N-Term(Dimethyl); K8(Dimethyl); EDIFYTSKVWCTFHRPELVR D3Z3P8 dehydrogenase 5 1 2639.352 3.44 C11(Carbamidomethyl) (Fragment) Pantothenate kinase 2 EDLARATLITITNNIGSIARMCALNENI N-Term(Dimethyl:2H(6)13C(2)); Q3U4S0 (Hallervorden-Spatz 1 4397.346 2.85 NQVVFVGNFLR C22(Carbamidomethyl) syndrome) EDSAGAMEDEEHEAAEGEQESATTEA DnaJ homolog subfamily F6ZL86 1 3288.388 2.87 RPRR C member 1 (Fragment) Serine/threonine-protein EDTETQAVATSPDGR E9Q470 1 1576.706 2.09 kinase WNK4 EEAAIQLLVRLAEGYR E9Q048 Protein Ermard 4 1830.990 2.94 Corticosteroid 11-beta- N-Term(Dimethyl); EECALEIIK Q3TJI8 dehydrogenase isozyme 4 1160.623 2.83 C3(Carbamidomethyl); K9(Dimethyl) 1 Protein unc-13 homolog N-Term(Dimethyl:2H(6)13C(2)); EEEEGQEGQDAMSRAK H3BJL3 1 1865.908 2.32 A (Fragment) K16(HeavyDimethyl) Isoform 3 of Glutamate K4(HeavyDimethyl); EEFKGSTVVELMK Q925T6-3 receptor-interacting 2 1568.922 2.78 K13(HeavyDimethyl) protein 1 Isoform 2 of Probable N-Term(Dimethyl:2H(6)13C(2)); EEGIEKGQILSSAADIAAAVQHATACH tRNA N6-adenosine K6(HeavyDimethyl); Q6PEB4-2 1 3197.754 2.83 LAK threonylcarbamoyltransf C26(Carbamidomethyl); erase, mitochondrial K30(HeavyDimethyl) Selenium-binding N-Term(Dimethyl); EEIVYLPCIYR G3UYY2 4 1482.769 2.91 protein 2 C8(Carbamidomethyl) Selenium-binding N-Term(Dimethyl:2H(6)13C(2)); EEIVYLPCIYR G3UYY2 3 1490.805 2.54 protein 2 C8(Carbamidomethyl) N-Term(Dimethyl); K3(Dimethyl); Fibrous sheath- EEKEMKSTWNGGLSK A2ARZ3 M5(Oxidation); K6(Dimethyl); 1 1851.975 2.23 interacting protein 2 K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Epidermal growth factor K16(HeavyDimethyl); EELIHHMDEVNDELMKKISHIK Q99K30 receptor kinase substrate 1 2832.624 2.65 K17(HeavyDimethyl); 8-like protein 2 K22(HeavyDimethyl) Eukaryotic translation EELLKLTEAVVTDYLNSGNANDAVSG F7CBP1 initiation factor 4 K5(Dimethyl) 1 3005.556 2.73 VR gamma 2 N-Term(Dimethyl:2H(6)13C(2)); K16(HeavyDimethyl); Zinc fingers and EEPGESSPGDETVAPKSGGTGKICK P70121 K22(HeavyDimethyl); 1 2661.486 2.34 homeoboxes protein 1 C24(Carbamidomethyl); K25(HeavyDimethyl) Transcription factor EEVAVESSTAEGKELNLRETGEDDVSS Q571C7 TFIIIB component B'' K13(Dimethyl); K35(Dimethyl) 1 3791.876 3.13 MVVVLGEK homolog Glutathione S- N-Term(Dimethyl); K15(Dimethyl); EEVVTIDTWMQGLLKPTCLYGQLPK P19157 1 3003.608 2.96 transferase P 1 C18(Carbamidomethyl); K25(Dimethyl) Isoform S-CaBP1 of EFDTNGDGEISTSELR Q9JLK7-2 Calcium-binding protein N-Term(Dimethyl:2H(6)13C(2)) 1 1805.875 2.12 1 Alcohol dehydrogenase N-Term(Dimethyl); EFGASECISPQDFSK P28474 9 1757.799 5.35 class-3 C7(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase EFGASECISPQDFSK P28474 C7(Carbamidomethyl); 14 1773.888 5.66 class-3 K15(HeavyDimethyl) Platelet-activating factor EFHVRNPQVHQR Q8VDG7 acetylhydrolase 2, 2 1546.810 1.98 cytoplasmic N-Term(Dimethyl); K3(Dimethyl); EFKAETFTFHSDICTLPEKEK P07724 Serum albumin C14(Carbamidomethyl); K19(Dimethyl); 5 2669.351 3.20 K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); EFKAETFTFHSDICTLPEKEK P07724 Serum albumin C14(Carbamidomethyl); 1 2701.529 2.79 K19(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl); K3(Dimethyl); EFKGLGDCLVK P51881 ADP/ATP translocase 2 2 1349.748 3.45 C8(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); EFKGLGDCLVK P51881 ADP/ATP translocase 2 1 1373.878 2.02 C8(Carbamidomethyl); K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); EFKLCVIPR Q05421 Cytochrome P450 2E1 K3(HeavyDimethyl); 2 1233.799 2.46 C5(Carbamidomethyl) N-Term(Dimethyl); K3(Dimethyl); EFKLCVIPRS Q05421 Cytochrome P450 2E1 1 1304.740 2.65 C5(Carbamidomethyl) EFLEYHRPPGAVHTCGGPGAFHLIVHL N-Term(Dimethyl); Q8K482 EMILIN-2 1 3195.640 2.81 K C15(Carbamidomethyl); K28(Dimethyl) EFLSLLQMMGQVNKFAASPTGQLYDM K14(HeavyDimethyl); P56593 Cytochrome P450 2A12 1 3720.931 2.89 FHSVMK K32(HeavyDimethyl) EFVEEFIWPAVQSSALYEDRYLLGTSL N-Term(Dimethyl:2H(6)13C(2)); J3QNG0 MCG15755 1 4023.099 3.05 ARPCIAR C31(Carbamidomethyl) Pleckstrin homology EFYSSQSQALQNSLQELTAEK B2RPU2 domain-containing K21(Dimethyl) 1 2429.165 2.75 family D member 1 Choline dehydrogenase, N-Term(Dimethyl:2H(6)13C(2)); EGAEGWDYAHCLPYFR Q8BJ64 1 2006.933 2.50 mitochondrial C11(Carbamidomethyl) N-Term(Dimethyl); EGALCEENMR P58252 Elongation factor 2 6 1236.536 2.56 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EGALCEENMR P58252 Elongation factor 2 1 1244.575 2.06 C5(Carbamidomethyl) EGEMIYQKVHSATLAIAEQHER Q2MHE5 Docking protein 6 K8(Dimethyl) 1 2568.324 2.30 NADH dehydrogenase [ubiquinone] 1 beta N-Term(Dimethyl); EGENYQQNCAK D3YUK4 1 1396.614 3.10 subcomplex subunit 10 C9(Carbamidomethyl); K11(Dimethyl) (Fragment)

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); [ubiquinone] 1 beta EGENYQQNCAK D3YUK4 C9(Carbamidomethyl); 1 1412.701 2.89 subcomplex subunit 10 K11(HeavyDimethyl) (Fragment) Isoform 2 of Tankyrase- EGEVAGLDMNISQFLKSLGLEHLR Q6PFX9-2 M9(Oxidation); K16(HeavyDimethyl) 1 2708.421 2.77 1 Isoform 3 of EGGGGSPAYHLPHPHPPQHAQYVGPY Q5RJI5-3 Serine/threonine-protein N-Term(Dimethyl); K30(Dimethyl) 1 3332.678 3.05 RLEK kinase BRSK1 Succinate N-Term(Dimethyl); dehydrogenase C4(Carbamidomethyl); EGICGSCAMNINGGNTLACTR Q9CQA3 4 2283.992 5.54 [ubiquinone] iron-sulfur C7(Carbamidomethyl); subunit, mitochondrial C19(Carbamidomethyl) Succinate N-Term(Dimethyl); dehydrogenase C4(Carbamidomethyl); EGICGSCAMNINGGNTLACTR Q9CQA3 1 2299.994 2.78 [ubiquinone] iron-sulfur C7(Carbamidomethyl); M9(Oxidation); subunit, mitochondrial C19(Carbamidomethyl)

Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase C4(Carbamidomethyl); EGICGSCAMNINGGNTLACTR Q9CQA3 2 2292.037 5.25 [ubiquinone] iron-sulfur C7(Carbamidomethyl); subunit, mitochondrial C19(Carbamidomethyl)

Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase C4(Carbamidomethyl); EGICGSCAMNINGGNTLACTR Q9CQA3 1 2308.033 3.73 [ubiquinone] iron-sulfur C7(Carbamidomethyl); M9(Oxidation); subunit, mitochondrial C19(Carbamidomethyl)

EGIDSDIGPFIKLSDPGIPVSVLTR B1ASP2 Tyrosine-protein kinase K12(HeavyDimethyl) 1 2661.522 2.73

Pyruvate dehydrogenase N-Term(Dimethyl); EGIECEVINLR Q9D051 E1 component subunit 1 1359.693 2.31 C5(Carbamidomethyl) beta, mitochondrial

Pyruvate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); EGIECEVINLR Q9D051 E1 component subunit 1 1367.745 2.19 C5(Carbamidomethyl) beta, mitochondrial N-Term(Dimethyl); K3(Dimethyl); Isoform 2 of Collagen EGKGQYLEMPLPMLPMDLK P25318-2 M13(Oxidation); M16(Oxidation); 3 2306.213 2.57 alpha-2(VIII) chain K19(Dimethyl) N-Term(Dimethyl); EGLALINGTQMITSLGCEALER P35492 Histidine ammonia-lyase 6 2404.234 5.21 C17(Carbamidomethyl) N-Term(Dimethyl); M11(Oxidation); EGLALINGTQMITSLGCEALER P35492 Histidine ammonia-lyase 1 2420.211 2.76 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EGLALINGTQMITSLGCEALER P35492 Histidine ammonia-lyase 4 2412.281 4.76 C17(Carbamidomethyl) N-Term(Dimethyl); EGLALINGTQMITSLGCEALERASAIAR P35492 Histidine ammonia-lyase 1 2973.559 3.12 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EGLALINGTQMITSLGCEALERASAIAR P35492 Histidine ammonia-lyase 3 2981.601 3.28 C17(Carbamidomethyl) DnaJ homolog subfamily EGLDGRGASHLDDER Q9QYI8 2 1626.749 2.29 B member 7 N-Term(Dimethyl:2H(6)13C(2)); EGNSPSFFNPEEAATVTSYLKQLLAPSS Putative helicase MOV- D3YVL0 K21(HeavyDimethyl); 1 3220.734 2.68 K 10 K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); M8(Oxidation); K13(HeavyDimethyl); EGPNYQWMPFSGKMPYPRPGTCPGGT Isoform A of O88632-2 C22(Carbamidomethyl); 1 4080.062 2.82 FTPSMKSTK Semaphorin-3F K32(HeavyDimethyl); K35(HeavyDimethyl) Isoform 2 of EGPVGGESDSEDMFEKTSGFGSGKPSE N-Term(Dimethyl); K16(Dimethyl); Q3UHU5-2 Microtubule cross- 1 4054.866 3.18 ASEPCPAELLR K24(Dimethyl); C32(Carbamidomethyl) linking factor 1 Aryl hydrocarbon N-Term(Dimethyl:2H(6)13C(2)); EGQQSSMRMCMGSR F7C9F6 receptor nuclear 1 1696.734 2.48 C10(Carbamidomethyl); M11(Oxidation) translocator (Fragment)

K5(HeavyDimethyl); EGRIKAFSTCASHFLSVSLFYGSLFFMY E9QAT7 Olfactory receptor C10(Carbamidomethyl); 1 4618.368 3.03 IRPNLLEEGDK M27(Oxidation); K39(HeavyDimethyl) Aspartate EGSSHNWQHITDQIGMFCFTGLKPEQV N-Term(Dimethyl); P05202 aminotransferase, 2 3487.657 4.23 ER C18(Carbamidomethyl); K23(Dimethyl) mitochondrial Aspartate N-Term(Dimethyl:2H(6)13C(2)); EGSSHNWQHITDQIGMFCFTGLKPEQV P05202 aminotransferase, C18(Carbamidomethyl); 4 3503.755 5.23 ER mitochondrial K23(HeavyDimethyl) M5(Oxidation); M14(Oxidation); DIP2 disco-interacting C18(Carbamidomethyl); EGSVMGVTVSRLAMLSQCQALSQACN B2RQC7 protein 2 homolog B C25(Carbamidomethyl); 1 4610.262 2.84 YSEGETVVNVLDFKK (Drosophila) K40(HeavyDimethyl); K41(HeavyDimethyl) Malate dehydrogenase, N-Term(Dimethyl); EGVVECSFVQSK P08249 1 1424.705 2.83 mitochondrial C6(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, EGVVECSFVQSK P08249 C6(Carbamidomethyl); 3 1440.793 2.73 mitochondrial K12(HeavyDimethyl) Isoform Mt-VDAC1 of Voltage-dependent anion-N-Term(Dimethyl); EHINLGCDVDFDIAGPSIR Q60932-2 4 2156.040 4.72 selective channel protein C7(Carbamidomethyl) 1 Isoform Mt-VDAC1 of Voltage-dependent anion-N-Term(Dimethyl:2H(6)13C(2)); EHINLGCDVDFDIAGPSIR Q60932-2 5 2164.091 4.37 selective channel protein C7(Carbamidomethyl) 1 N-Term(Dimethyl:2H(6)13C(2)); EHQDSLDPNSPRDFIDCFLTK P33267 Cytochrome P450 2F2 C17(Carbamidomethyl); 2 2606.311 3.12 K21(HeavyDimethyl)

Isoform 1 of K6(Dimethyl); C17(Carbamidomethyl); EHQMAKTGGTQTDLFTCGKCK P10711-2 Transcription elongation K19(Dimethyl); C20(Carbamidomethyl); 1 2482.203 2.69 factor A protein 1 K21(Dimethyl)

EHSLHHSHEMAEKEMTDNMSNGAPQ D3YWQ9 Protein Tmem196 K13(Dimethyl); M19(Oxidation) 1 4201.823 3.55 LMFNGRVQSMF N-Term(Dimethyl); EICNAYTELNDPVR Q99MN1 Lysine--tRNA ligase 2 1721.811 3.37 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EICNAYTELNDPVR Q99MN1 Lysine--tRNA ligase 2 1729.857 2.44 C3(Carbamidomethyl) N-Term(Dimethyl); EIDITPVMNGFASLPPPYQLCFIPL Q3UT49 Cytochrome P450 2C29 3 2860.471 3.39 C21(Carbamidomethyl) N-Term(Dimethyl); M8(Oxidation); EIDITPVMNGFASLPPPYQLCFIPL Q3UT49 Cytochrome P450 2C29 1 2876.469 2.48 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EIDITPVMNGFASLPPPYQLCFIPL Q3UT49 Cytochrome P450 2C29 1 2868.520 3.07 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EIDITPVMNGFASLPPPYQLCFIPL Q3UT49 Cytochrome P450 2C29 3 2884.505 2.85 M8(Oxidation); C21(Carbamidomethyl)

Cell cycle control N-Term(Dimethyl); EIEIDYTGTEPSSPCNK Q8VEK0 3 1995.925 3.52 protein 50A C15(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cell cycle control EIEIDYTGTEPSSPCNK Q8VEK0 C15(Carbamidomethyl); 5 2012.006 3.40 protein 50A K17(HeavyDimethyl) Ras-related C3 N-Term(Dimethyl:2H(6)13C(2)); EIGAVKYLECSALTQR P63001 botulinum toxin K6(HeavyDimethyl); 1 1910.104 2.59 substrate 1 C10(Carbamidomethyl) Carbamoyl-phosphate N-Term(Dimethyl); K7(Dimethyl); EIGFSDKQISKCLGLTEAQTR Q8C196 synthase [ammonia], 11 2465.305 3.63 K11(Dimethyl); C12(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K7(HeavyDimethyl); EIGFSDKQISKCLGLTEAQTR Q8C196 synthase [ammonia], 11 2489.442 4.24 K11(HeavyDimethyl); mitochondrial C12(Carbamidomethyl) Electron transfer C7(Carbamidomethyl); EIIAVSCGPSQCQETIR Q9DCW4 2 1947.925 2.45 flavoprotein subunit beta C12(Carbamidomethyl) N-Term(Dimethyl); Electron transfer EIIAVSCGPSQCQETIR Q9DCW4 C7(Carbamidomethyl); 18 1975.954 5.65 flavoprotein subunit beta C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Electron transfer EIIAVSCGPSQCQETIR Q9DCW4 C7(Carbamidomethyl); 21 1983.997 6.44 flavoprotein subunit beta C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Electron transfer EIIAVSCGPSQCQETIRTALAMGADR Q9DCW4 C7(Carbamidomethyl); 2 2870.442 3.11 flavoprotein subunit beta C12(Carbamidomethyl) N-Term(Dimethyl); EIIAVSCGPSQCQETIRTALAMGADRGI Electron transfer Q9DCW4 C7(Carbamidomethyl); 1 4985.573 3.64 HVEIPGAQAESLGPLQVAR flavoprotein subunit beta C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EIIAVSCGPSQCQETIRTALAMGADRGI Electron transfer Q9DCW4 C7(Carbamidomethyl); 1 4993.584 4.00 HVEIPGAQAESLGPLQVAR flavoprotein subunit beta C12(Carbamidomethyl) Serine/threonine-protein EIIEGCIRTDK Q80UE6 C6(Carbamidomethyl); K11(Dimethyl) 1 1361.717 2.28 kinase WNK4 60S ribosomal protein N-Term(Dimethyl); EILGTAQSVGCNVDGR P35979 1 1703.834 3.35 L12 C11(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); EILGTAQSVGCNVDGR P35979 4 1711.873 3.42 L12 C11(Carbamidomethyl) N-Term(Dimethyl); EILGTAQSVGCNVDGRHPHDIIDDINSG 60S ribosomal protein P35979 C11(Carbamidomethyl); 2 3731.736 3.89 AVECPAS L12 C32(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EILGTAQSVGCNVDGRHPHDIIDDINSG 60S ribosomal protein P35979 C11(Carbamidomethyl); 1 3739.787 5.37 AVECPAS L12 C32(Carbamidomethyl) N-Term(Dimethyl); Zinc finger homeobox C4(Carbamidomethyl); EIPCNECATSFPSLQKYMEHHCP V9GXP5 1 2907.277 2.78 protein 4 (Fragment) C7(Carbamidomethyl); K16(Dimethyl); M18(Oxidation); C22(Carbamidomethyl) EIPMAVLDISSAQHPVKAGLSDAFMIL Plexin domain- M4(Oxidation); K17(HeavyDimethyl); Q91ZV7 1 4074.134 2.88 NSSPEVPASQR containing protein 1 M25(Oxidation) Corticosteroid 11-beta- N-Term(Dimethyl); K13(Dimethyl); EISGIINAQASPKEECALEIIK Q3TJI8 dehydrogenase isozyme 7 2497.366 5.08 C16(Carbamidomethyl); K22(Dimethyl) 1 N-Term(Dimethyl:2H(6)13C(2)); Corticosteroid 11-beta- K13(HeavyDimethyl); EISGIINAQASPKEECALEIIK Q3TJI8 dehydrogenase isozyme 2 2521.490 4.85 C16(Carbamidomethyl); 1 K22(HeavyDimethyl) Corticosteroid 11-beta- N-Term(Dimethyl); K13(Dimethyl); EISGIINAQASPKEECALEIIKGTALR Q3TJI8 dehydrogenase isozyme 2 2995.643 3.10 C16(Carbamidomethyl); K22(Dimethyl) 1 N-Term(Dimethyl:2H(6)13C(2)); Corticosteroid 11-beta- K13(HeavyDimethyl); EISGIINAQASPKEECALEIIKGTALR Q3TJI8 dehydrogenase isozyme 1 3019.809 3.93 C16(Carbamidomethyl); 1 K22(HeavyDimethyl) N-Term(Dimethyl); EIVHIQAGQCGNQIGAK P99024 Tubulin beta-5 chain 4 1878.978 4.27 C10(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EIVHIQAGQCGNQIGAK P99024 Tubulin beta-5 chain C10(Carbamidomethyl); 14 1895.065 3.56 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); EIVHLQAGQCGNQIGAK P99024 Tubulin beta-5 chain C10(Carbamidomethyl); 12 1895.064 3.43 K17(HeavyDimethyl) Hairy and enhancer of K2(HeavyDimethyl); EKELLAEFANYFHYGYHECMKNLVHY Q7TS99 split-related protein C19(Carbamidomethyl); 1 4077.032 2.78 LTTVER HELT K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); DBF4-type zinc finger- EKHAELTSKSTESHSEVSSASTASHPVT K2(HeavyDimethyl); Q5SS00 containing protein 2 1 3742.000 3.24 EPYVGK K9(HeavyDimethyl); homolog K34(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Zinc finger homeobox EKHPEPGGSCVYCK H3BKK3 C10(Carbamidomethyl); 1 1755.942 2.23 protein 4 (Fragment) C13(Carbamidomethyl); K14(HeavyDimethyl) Isoform 6 of Calcium- EKKSEPQELMQLEGYTVDYTDPHPGL K2(Dimethyl); K3(Dimethyl); Q8BYR5-6 dependent secretion 1 4280.125 2.88 QGGQVFFNAVK M10(Oxidation); K37(Dimethyl) activator 2 N-Term(Dimethyl); K2(Dimethyl); EKLCYVALDFEQEMATAASSSSLEK E9Q1F2 Actin, cytoplasmic 1 1 2891.389 3.18 C4(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); EKLCYVALDFEQEMATAASSSSLEK E9Q1F2 Actin, cytoplasmic 1 1 2915.553 2.81 C4(Carbamidomethyl); K25(HeavyDimethyl) Unconventional myosin- K2(HeavyDimethyl); M20(Oxidation); EKNEIQNRLEEDQEDMNELMK E9QA74 1 2723.363 2.95 XVIIIa K21(HeavyDimethyl) Retinoic acid early- N-Term(Dimethyl:2H(6)13C(2)); EKPRSTSRSPSITQLTSTSPLPPPSHSTS Q9CZQ6 inducible protein 1- K2(HeavyDimethyl); 1 3299.885 2.87 K epsilon K30(HeavyDimethyl) Heterogeneous nuclear N-Term(Dimethyl); K2(Dimethyl); EKPYFPIPEDCTFIQNVPLEDR G3XA10 1 2763.377 3.39 ribonucleoprotein U C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Heterogeneous nuclear EKPYFPIPEDCTFIQNVPLEDR G3XA10 K2(HeavyDimethyl); 1 2779.460 3.90 ribonucleoprotein U C11(Carbamidomethyl) Sodium-dependent K2(Dimethyl); C12(Carbamidomethyl); EKQFPALGLDPCLLEDELDK Q8BJI1 neutral amino acid 1 2386.255 2.71 K20(Dimethyl) transporter SLC6A17 ELACDDPEAEQVALLAVDYLNNHLLQ Alpha-2-HS- N-Term(Dimethyl); P29699 1 3341.696 4.63 GFK glycoprotein C4(Carbamidomethyl); K29(Dimethyl) Guanine nucleotide- N-Term(Dimethyl); binding protein ELAGHTGYLSCCR H3BKR2 C11(Carbamidomethyl); 1 1551.698 2.40 G(I)/G(S)/G(T) subunit C12(Carbamidomethyl) beta-1 (Fragment) Guanine nucleotide- N-Term(Dimethyl:2H(6)13C(2)); binding protein ELAGHTGYLSCCR H3BKR2 C11(Carbamidomethyl); 1 1559.740 2.76 G(I)/G(S)/G(T) subunit C12(Carbamidomethyl) beta-1 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); Coatomer subunit ELAPAVSVLQLFCSSPK Q9QZE5 C13(Carbamidomethyl); 1 1918.133 3.35 gamma-1 K17(HeavyDimethyl) N-Term(Dimethyl); K8(Dimethyl); ELAQQIQKVILALGDYMGATCHACIG Eukaryotic initiation M17(Oxidation); Q8BTU6 1 4118.011 3.15 GTNVRNEMQK factor 4A-II C21(Carbamidomethyl); C24(Carbamidomethyl); K36(Dimethyl) MCG2872, isoform N-Term(Dimethyl); ELAQQVQQVAAEYCR S4R1I6 6 1820.892 4.10 CRA_b C14(Carbamidomethyl) MCG2872, isoform N-Term(Dimethyl:2H(6)13C(2)); ELAQQVQQVAAEYCR S4R1I6 4 1828.935 4.37 CRA_b C14(Carbamidomethyl) Isoform 2 of ELEKVTGTQFPEAPLPVPCNPNDVSHG N-Term(Dimethyl); K4(Dimethyl); P34914-2 Bifunctional epoxide 2 4030.124 3.53 YVTVKPGIR C19(Carbamidomethyl); K32(Dimethyl) hydrolase 2 N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of ELEKVTGTQFPEAPLPVPCNPNDVSHG K4(HeavyDimethyl); P34914-2 Bifunctional epoxide 1 4054.258 3.32 YVTVKPGIR C19(Carbamidomethyl); hydrolase 2 K32(HeavyDimethyl) Myeloid differentiation ELETRPDPTRSLLDAWQGR F6SPW1 primary response protein N-Term(Dimethyl:2H(6)13C(2)) 1 2276.235 2.26 MyD88 (Fragment) T-lymphoma invasion N-Term(Dimethyl); K21(Dimethyl); ELFALTDAESEEHYHLDVAIKTMNKV E9Q1R7 and metastasis-inducing M23(Oxidation); K25(Dimethyl); 1 4170.137 3.37 ASHINEMQK protein 1 K35(Dimethyl) N-Term(Dimethyl); ELGSPPGISLETIDAAFSCPGSSR Q91X72 Hemopexin 6 2476.229 5.17 C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ELGSPPGISLETIDAAFSCPGSSR Q91X72 Hemopexin 4 2484.265 4.96 C19(Carbamidomethyl) Probable N-Term(Dimethyl); ELHLSLSATYCGAHSVPK Q9DBA8 1 2026.041 2.52 imidazolonepropionase C11(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Probable ELHLSLSATYCGAHSVPK Q9DBA8 C11(Carbamidomethyl); 1 2042.135 3.79 imidazolonepropionase K18(HeavyDimethyl) Isoform 2 of ELHRRADGDSGSHHGLGGQSCFNLEM Q3UHU5-2 Microtubule cross- C21(Carbamidomethyl); M26(Oxidation) 1 4009.834 2.94 EEDHLYALR linking factor 1 N-Term(Dimethyl:2H(6)13C(2)); ELICWGDSVKLR F8VPN4 Protein Agl C4(Carbamidomethyl); 2 1547.921 2.89 K10(HeavyDimethyl) Mediator of RNA ELIFPSNYDLLRHLQYATHFPIPLDESSS polymerase II Q8BQM9 C32(Carbamidomethyl) 2 4227.070 3.16 HECNQR transcription subunit 12- like protein ELIMGEDPAQPRKYK F7C528 Protein Chd3 (Fragment) K13(Dimethyl); K15(Dimethyl) 1 1830.989 2.49 N-Term(Dimethyl:2H(6)13C(2)); G protein-regulated ELISAPCLISVVQHTHHAIQRDAPNTST C7(Carbamidomethyl); Q8BWS5 inducer of neurite 1 4208.212 3.35 CAVPEGSLVK C29(Carbamidomethyl); outgrowth 3 K38(HeavyDimethyl) N-Term(Dimethyl); K3(Dimethyl); ELKGKFPDVPGFSWVTPCISAK Q61176 Arginase-1 K5(Dimethyl); C18(Carbamidomethyl); 1 2575.398 2.87 K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); ELKGKFPDVPGFSWVTPCISAK Q61176 Arginase-1 K5(HeavyDimethyl); 1 2607.571 2.97 C18(Carbamidomethyl); K22(HeavyDimethyl) Peroxisomal trans-2- N-Term(Dimethyl); ELLHLGCNVVIASR Q3UXD9 9 1608.889 3.95 enoyl-CoA reductase C7(Carbamidomethyl) Peroxisomal trans-2- N-Term(Dimethyl:2H(6)13C(2)); ELLHLGCNVVIASR Q3UXD9 10 1616.925 3.54 enoyl-CoA reductase C7(Carbamidomethyl)

Osteopetrosis-associated N-Term(Dimethyl:2H(6)13C(2)); ELLMDFANSSAELTACMVRSARPVR Q8BGT0 1 2876.469 2.35 transmembrane protein 1 C16(Carbamidomethyl); M17(Oxidation)

ELLTEFGYKGEETPVIVGSALCALEQR Isoform 2 of Elongation N-Term(Dimethyl); K9(Dimethyl); Q8BFR5-2 2 3831.979 4.82 DPELGVK factor Tu, mitochondrial C22(Carbamidomethyl); K34(Dimethyl) Isoform 2 of N-Term(Dimethyl); K11(Dimethyl); ELLTTLQEASKSPGENCQHQLAK A3KMP2-2 Tetratricopeptide repeat 1 2666.385 3.89 C17(Carbamidomethyl); K23(Dimethyl) protein 38 N-Term(Dimethyl:2H(6)13C(2)); Tetratricopeptide repeat K11(HeavyDimethyl); ELLTTLQEASKSPGENCQHQLAK A3KMP2 2 2690.519 3.19 protein 38 C17(Carbamidomethyl); K23(HeavyDimethyl) GTP-binding protein N-Term(Dimethyl); ELNARPLEVFMCSVLK Q9CQC9 1 1962.063 2.45 SAR1b C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTP-binding protein ELNARPLEVFMCSVLK Q9CQC9 C12(Carbamidomethyl); 2 1978.145 2.82 SAR1b K16(HeavyDimethyl) GTP-binding protein N-Term(Dimethyl); ELNARPLEVFMCSVLKR Q9CQC9 1 2118.166 2.90 SAR1b C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTP-binding protein ELNARPLEVFMCSVLKR Q9CQC9 C12(Carbamidomethyl); 2 2134.248 3.57 SAR1b K16(HeavyDimethyl) Guanine nucleotide- N-Term(Dimethyl); binding protein ELPGHTGYLSCCR D3Z1T4 C11(Carbamidomethyl); 2 1577.714 2.44 G(I)/G(S)/G(T) subunit C12(Carbamidomethyl) beta-2 (Fragment) Guanine nucleotide- N-Term(Dimethyl:2H(6)13C(2)); binding protein ELPGHTGYLSCCR D3Z1T4 C11(Carbamidomethyl); 2 1585.760 2.45 G(I)/G(S)/G(T) subunit C12(Carbamidomethyl) beta-2 (Fragment) N-Term(Dimethyl); ELPPDQAEYCIAR A1BN54 Alpha actinin 1a 10 1589.757 2.48 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ELPPDQAEYCIAR A1BN54 Alpha actinin 1a 19 1597.800 2.88 C10(Carbamidomethyl) Mitogen-activated N-Term(Dimethyl:2H(6)13C(2)); protein kinase kinase ELPQVCVGAEGPEGPGCR F6RPB0 C6(Carbamidomethyl); 1 1947.927 2.16 kinase kinase 2 C17(Carbamidomethyl) (Fragment) K6(HeavyDimethyl); ELQNMKLLLGQEEGLRHGLEAQVK P59242-2 Isoform 2 of Cingulin 1 2805.627 2.29 K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ELQRFELPSDWPGFPVVPSGGNSGPCE Histone-lysine N- Q6PDK2 C26(Carbamidomethyl); 1 3538.872 3.07 AVLPK methyltransferase 2D K32(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); ELSGTIKEILGTAQSVGCNVDGRHPHD 60S ribosomal protein P35979 C18(Carbamidomethyl); 1 4488.154 4.59 IIDDINSGAVECPAS L12 C39(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ELSGTIKEILGTAQSVGCNVDGRHPHD 60S ribosomal protein K7(HeavyDimethyl); P35979 1 4504.296 5.21 IIDDINSGAVECPAS L12 C18(Carbamidomethyl); C39(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Serine--tRNA ligase, ELVSCSNCTDYQAR P26638 C5(Carbamidomethyl); 2 1738.789 2.39 cytoplasmic C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ELWLGDCDVTNSGCSSLANVLLANR Q91VI7 Ribonuclease inhibitor C7(Carbamidomethyl); 2 2800.380 3.50 C14(Carbamidomethyl) Lysine-specific N-Term(Dimethyl:2H(6)13C(2)); EMAMGLNVLDPHTSHSWLCDGR Q6ZPY7 1 2578.200 2.65 demethylase 3B M4(Oxidation); C19(Carbamidomethyl) EMAVFYCNTNADNITIHWVSNNSLLV Q9D2Z1 Protein Ceacam20 C7(Carbamidomethyl); K32(Dimethyl) 1 3824.860 3.02 LNERMK FYVE, RhoGEF and PH EMEETPVAASGATAEPPEASQTRDKT A2ALP5 domain-containing K25(HeavyDimethyl) 1 2739.357 2.60 protein 1 Proline dehydrogenase N-Term(Dimethyl); EMESCTSEAERDGSGANKR Q9WU79 1 2169.949 2.61 1, mitochondrial C5(Carbamidomethyl); K18(Dimethyl)

Proline dehydrogenase N-Term(Dimethyl); M2(Oxidation); EMESCTSEAERDGSGANKR Q9WU79 1 2185.936 2.98 1, mitochondrial C5(Carbamidomethyl); K18(Dimethyl) EMLLTCGEDTADRPPVPIFEYLGVKPG N-Term(Dimethyl); P11714 Cytochrome P450 2D9 3 4600.325 4.98 SQGVVLAPYGPEWR C6(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EMLLTCGEDTADRPPVPIFEYLGVKPG P11714 Cytochrome P450 2D9 C6(Carbamidomethyl); 1 4616.461 3.62 SQGVVLAPYGPEWR K25(HeavyDimethyl) N-Term(Dimethyl); ENEFFIVTQTCK D3Z2B2 Kininogen-1 (Fragment) 6 1571.778 2.94 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); Ras-specific guanine C6(Carbamidomethyl); ENILQCVDNIRCNGLMTIVFEENSK D3Z6K8 nucleotide-releasing 1 3068.487 2.83 C12(Carbamidomethyl); factor 2 M16(Oxidation); K25(Dimethyl) N-Term(Dimethyl); ENIPLQFSEDCLYLNIYTPADLTK Q8VCT4 Carboxylesterase 1D 7 2913.477 4.38 C11(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ENIPLQFSEDCLYLNIYTPADLTK Q8VCT4 Carboxylesterase 1D C11(Carbamidomethyl); 8 2929.562 5.10 K24(HeavyDimethyl) Isoform 2 of Transmembrane and ENQLDYESEKMEILRLAQSK Q9D9D5-2 K10(Dimethyl); K20(Dimethyl) 1 2480.273 2.29 coiled-coil domain- containing protein 5A N-Term(Dimethyl); ENYGELADCCTK P07724 Serum albumin C9(Carbamidomethyl); 5 1515.640 2.96 C10(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C9(Carbamidomethyl); ENYGELADCCTK P07724 Serum albumin 7 1531.732 3.63 C10(Carbamidomethyl); K12(HeavyDimethyl) Isoform 5 of Peroxisomal coenzyme N-Term(Dimethyl); EPGEVCFPGGKRDPVDTDDTATALR Q99P30-5 3 2759.325 2.95 A diphosphatase C6(Carbamidomethyl); K11(Dimethyl) NUDT7 Isoform 5 of N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal coenzyme EPGEVCFPGGKRDPVDTDDTATALR Q99P30-5 C6(Carbamidomethyl); 1 2775.417 3.09 A diphosphatase K11(HeavyDimethyl) NUDT7 Zinc finger and BTB N-Term(Dimethyl:2H(6)13C(2)); EPSYLGTLLGLDSTAAVQNMCSSEHR Q811F1 domain-containing 1 2872.368 2.43 C21(Carbamidomethyl) protein 41 EPVVQHGPFVMNTNEEISQAILDFRNA N-Term(Dimethyl:2H(6)13C(2)); Q9D711 Pirin 1 3987.059 3.16 KNGFEGAR K28(HeavyDimethyl) 4- N-Term(Dimethyl); EQGATVLCGGEVYVPEDPK Q9JLJ2 trimethylaminobutyralde 2 2104.029 2.70 C8(Carbamidomethyl); K19(Dimethyl) hyde dehydrogenase

4- N-Term(Dimethyl); EQGATVLCGGEVYVPEDPKLK Q9JLJ2 trimethylaminobutyralde C8(Carbamidomethyl); K19(Dimethyl); 7 2373.238 4.46 hyde dehydrogenase K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- C8(Carbamidomethyl); EQGATVLCGGEVYVPEDPKLK Q9JLJ2 trimethylaminobutyralde 11 2397.358 5.13 K19(HeavyDimethyl); hyde dehydrogenase K21(HeavyDimethyl) NADPH--cytochrome N-Term(Dimethyl); K4(Dimethyl); EQGKEVGETLLYYGCR P37040 7 1957.967 3.69 P450 reductase C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NADPH--cytochrome EQGKEVGETLLYYGCR P37040 K4(HeavyDimethyl); 4 1974.055 4.31 P450 reductase C15(Carbamidomethyl) EQGLGSNQSSQYGQYR E9QNP3 Hornerin N-Term(Dimethyl:2H(6)13C(2)) 1 1837.899 2.03 N-Term(Dimethyl:2H(6)13C(2)); EQGVTFPSGEVQEQLICSLYQPAGLAP P19096 Fatty acid synthase C17(Carbamidomethyl); 1 4506.316 3.99 ESLEYIEAHGTGTK K41(HeavyDimethyl) Ras-related protein Rap- K7(Dimethyl); M14(Oxidation); EQILRVKDTEDVPMILVGNK P62835 1 2369.286 2.96 1A K20(Dimethyl) Homeobox protein N-Term(Dimethyl:2H(6)13C(2)); EQLAMRTDLTEAR A2AIK5 1 1585.833 1.98 aristaless-like 4 M5(Oxidation) Protein 8030474K03Rik N-Term(Dimethyl:2H(6)13C(2)); EQLAVMQALSETFQDP F6QFT7 1 1858.948 2.08 (Fragment) M6(Oxidation) Isoform 4 of Protein N-Term(Dimethyl); ERFLMLGTCTGQLK Q80TR8-4 1 1709.887 2.25 VPRBP C9(Carbamidomethyl); K14(Dimethyl) Methylthioribulose-1- N-Term(Dimethyl); ERIQPEDMFVCDINEQDISGPPASK Q9WVQ5 1 2931.406 2.90 phosphate dehydratase C11(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ERLCDAVDVLLSLR Q8BLN5 Lanosterol synthase 1 1694.977 2.68 C4(Carbamidomethyl) N-Term(Dimethyl); C15(Carbamidomethyl); ERNGPTPLHLAAQACSLEATICLLCFK Ankyrin and armadillo A2RT91 C22(Carbamidomethyl); 1 4076.045 3.02 ADYTLTEK repeat-containing protein C25(Carbamidomethyl); K27(Dimethyl); K35(Dimethyl) Bifunctional N-Term(Dimethyl); ERPAPAVSSTCATAEDSSVLYSR Q8CGC7 glutamate/proline--tRNA 1 2482.183 2.80 C11(Carbamidomethyl) ligase Bifunctional N-Term(Dimethyl:2H(6)13C(2)); ERPAPAVSSTCATAEDSSVLYSR Q8CGC7 glutamate/proline--tRNA 4 2490.222 3.32 C11(Carbamidomethyl) ligase ERPPLVPLQKRMTPLSVYPPGETHVGL N-Term(Dimethyl); K10(Dimethyl); Q2QI47 Usherin 1 3526.883 2.92 ADTR M12(Oxidation) PH domain leucine-rich N-Term(Dimethyl:2H(6)13C(2)); ERQQHLLQVPAEASDEGIVISANEDES Q8CHE4 repeat-containing protein K31(HeavyDimethyl); 1 3585.966 3.08 GLSKK phosphatase 1 K32(HeavyDimethyl) CUB domain-containing ERSGLACQSGRAFMIIQEQQSR Q5U462 C7(Carbamidomethyl) 2 2552.251 2.70 protein 1 ERSLSVPTDSGVTSVDYDEEQK B1AXH1 NHS-like protein 2 K22(HeavyDimethyl) 1 2477.199 2.51 Methylmalonate- semialdehyde N-Term(Dimethyl); ERVCNLIDSGTKEGASILLDGR Q9EQ20 dehydrogenase 1 2459.305 2.96 C4(Carbamidomethyl); K12(Dimethyl) [acylating], mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl:2H(6)13C(2)); ERVCNLIDSGTKEGASILLDGR Q9EQ20 dehydrogenase C4(Carbamidomethyl); 1 2475.374 2.44 [acylating], K12(HeavyDimethyl) mitochondrial N-Term(Dimethyl); Cysteine-rich with EGF- ESGQCTDIDECSLEEK Q9CYA0 C5(Carbamidomethyl); 1 1955.821 3.24 like domain protein 2 C11(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cysteine-rich with EGF- C5(Carbamidomethyl); ESGQCTDIDECSLEEK Q9CYA0 1 1971.911 3.53 like domain protein 2 C11(Carbamidomethyl); K16(HeavyDimethyl) ESGQSTYVVVHDDEDEFPGAQR E9Q5A6 Protein Nr1h5 2 2465.101 2.75 Isoform Alpha II of ESIHDGTVTHTFCGTIEYMAPEILMRS Q8BSK8-2 Ribosomal protein S6 C13(Carbamidomethyl); M25(Oxidation) 2 3575.670 2.90 GHNR kinase beta-1 Isoform Peroxisomal of Serine--pyruvate N-Term(Dimethyl:2H(6)13C(2)); ESLALIAEQGLENCWR O35423-2 1 1925.013 2.42 aminotransferase, C14(Carbamidomethyl) mitochondrial E3 ubiquitin-protein N-Term(Dimethyl:2H(6)13C(2)); ESLDPDAYALFHK F6XVP7 ligase RNF31 1 1577.861 2.12 K13(HeavyDimethyl) (Fragment) Kinesin light chain 1 ESLNMDVVKYESGPDGGEEGIPR F6UYN4 K9(HeavyDimethyl) 1 2514.239 2.60 (Fragment) N-Term(Dimethyl); ESNCYDPERVK Q68FD5 Clathrin heavy chain 1 2 1452.678 2.25 C4(Carbamidomethyl); K11(Dimethyl) ESPLSLYNEELVSMNVQGDYEPIDATG J3QNG0 MCG15755 4 3927.910 4.54 FININSLR ESSIYLIGGSIPEEDAGKLYNTCSVFGP N-Term(Dimethyl); K18(Dimethyl); Q9JHW2 Omega-amidase NIT2 1 3799.935 4.19 DGSLLVK C23(Carbamidomethyl); K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ESSIYLIGGSIPEEDAGKLYNTCSVFGP K18(HeavyDimethyl); Q9JHW2 Omega-amidase NIT2 1 3824.086 4.17 DGSLLVK C23(Carbamidomethyl); K35(HeavyDimethyl) Pleckstrin homology ESTSYGRQDGTVWIPSPSR E9PX43 domain-containing N-Term(Dimethyl:2H(6)13C(2)) 1 2159.089 2.21 family A member 6 ESVYLLLDMIVQESPFLTMDLLESCFP M19(Oxidation); P28660 Nck-associated protein 1 1 4824.413 3.71 YVLLRNAYHAVYK C25(Carbamidomethyl); K40(Dimethyl)

tRNA (guanine-N(7)-)- N-Term(Dimethyl:2H(6)13C(2)); ESWAMLEGSVGTDDSFRSLYKATFDN Q9EP82 methyltransferase non- M5(Oxidation); K21(HeavyDimethyl); 1 3773.950 3.18 MTSYLK catalytic subunit WDR4 K32(HeavyDimethyl)

N-Term(Dimethyl); ETAAATFFSSSCVPCADGK D3YY36 Protein 1300017J02Rik C12(Carbamidomethyl); 1 2061.929 2.99 C15(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C12(Carbamidomethyl); ETAAATFFSSSCVPCADGK D3YY36 Protein 1300017J02Rik 2 2078.020 3.44 C15(Carbamidomethyl); K19(HeavyDimethyl) DCP1 decapping ETDNGLMALGGQELPAASSSLLLPLQN B9EIX0 enzyme homolog b (S. 2 4210.193 3.28 WESSTVASRPLTR cerevisiae) Malate dehydrogenase, N-Term(Dimethyl); ETECTYFSTPLLLGK P08249 6 1814.910 4.17 mitochondrial C4(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, ETECTYFSTPLLLGK P08249 C4(Carbamidomethyl); 2 1831.008 2.83 mitochondrial K15(HeavyDimethyl) N-Term(Dimethyl); Malate dehydrogenase, ETECTYFSTPLLLGKK P08249 C4(Carbamidomethyl); K15(Dimethyl); 6 1971.050 3.39 mitochondrial K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, C4(Carbamidomethyl); ETECTYFSTPLLLGKK P08249 1 1995.186 2.67 mitochondrial K15(HeavyDimethyl); K16(HeavyDimethyl) Hemoglobin subunit beta-C11(Carbamidomethyl); K13(Dimethyl); ETFAHLSELHCDKLHVDPENFK P04444 1 2722.350 2.27 H1 K22(Dimethyl) ETGALQDSVLHCVR G8JL63 Protein unc-79 homolog C12(Carbamidomethyl) 2 1584.770 2.17 Ornithine N-Term(Dimethyl); K3(Dimethyl); ETKDCDAWKVCLR P29758 aminotransferase, C5(Carbamidomethyl); K9(Dimethyl); 3 1764.869 2.46 mitochondrial C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Ornithine K3(HeavyDimethyl); ETKDCDAWKVCLR P29758 aminotransferase, C5(Carbamidomethyl); 1 1789.010 2.25 mitochondrial K9(HeavyDimethyl); C11(Carbamidomethyl) ETMDELGLPDAMNMDSADLFASATEL Isoform 2 of Protein Q4QQM5-2 M12(Oxidation); M14(Oxidation) 2 3303.426 2.82 AEQR FAM73A Isoform 2 of Cytidine monophosphate-N- ETNTKNDPNQLNNLIR Q61419-2 K5(HeavyDimethyl) 1 1920.008 2.07 acetylneuraminic acid hydroxylase ETSFVPLNTATEKLSSKPSLVFQSSQTT K13(Dimethyl); K17(Dimethyl); Q9JJN0 DNA polymerase eta 1 3892.982 3.09 GSQSFFK K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ETSNIYDGSAFCADMAVQNFVGDACR Q8VC12 Urocanate hydratase C12(Carbamidomethyl); 1 2934.276 3.64 C25(Carbamidomethyl) ETTQVVQEAEPESGAQPRPGYFKQFQ N-Term(Dimethyl); K23(Dimethyl); S4R294 Protein PRRC2C 1 3713.876 3.06 KSLPPR K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Gamma- ETVPASYDQGLLNQCK Q9Z2A9-2 C15(Carbamidomethyl); 1 1895.011 2.20 glutamyltransferase 5 K16(HeavyDimethyl) N-Term(Dimethyl); ETVSEESNVLCLSK P58252 Elongation factor 2 10 1650.823 4.94 C11(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ETVSEESNVLCLSK P58252 Elongation factor 2 C11(Carbamidomethyl); 7 1666.910 4.79 K14(HeavyDimethyl) N-Term(Dimethyl); ETVSEESNVLCLSKSPNKHNR P58252 Elongation factor 2 C11(Carbamidomethyl); K14(Dimethyl); 1 2512.281 2.80 K18(Dimethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); EVAELAECIGSGLIQK D3Z041 2 1772.945 5.05 CoA ligase 1 C8(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- EVAELAECIGSGLIQK D3Z041 C8(Carbamidomethyl); 1 1789.040 2.88 CoA ligase 1 K16(HeavyDimethyl) EVAGQVGVPLQDLMVRNDSPCGTTIG N-Term(Dimethyl:2H(6)13C(2)); Q9Z2W0 Aspartyl aminopeptidase 2 3386.823 3.80 PILASR C21(Carbamidomethyl) C10(Carbamidomethyl); EVAVEAQVECAPPPDVWCHIK Q8CJH3 Plexin-B1 1 2462.188 2.68 C18(Carbamidomethyl); K21(Dimethyl) Serine N-Term(Dimethyl:2H(6)13C(2)); EVCDEVRAHLLADMAHISGLVAAK Q9CZN7 hydroxymethyltransferas C3(Carbamidomethyl); 1 2677.483 2.87 e K24(HeavyDimethyl) Staphylococcal nuclease N-Term(Dimethyl); EVCFTIENKTPQGR Q3TJ56 domain-containing 3 1734.875 3.16 C3(Carbamidomethyl); K9(Dimethyl) protein 1 Staphylococcal nuclease N-Term(Dimethyl:2H(6)13C(2)); EVCFTIENKTPQGR Q3TJ56 domain-containing C3(Carbamidomethyl); 4 1750.962 2.96 protein 1 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Metalloendopeptidase EVCNCPPLSGPDPR Q9D8H7 C3(Carbamidomethyl); 1 1633.781 2.16 OMA1, mitochondrial C5(Carbamidomethyl) Isoform 4 of Mitochondrial peptide N-Term(Dimethyl); EVCSEKTGHAEVVR Q9D6Y7-4 3 1656.838 3.66 methionine sulfoxide C3(Carbamidomethyl); K6(Dimethyl) reductase N-Term(Dimethyl); EVDEYCKIGRYNLTPTIFFCATPPDDG C6(Carbamidomethyl); K7(Dimethyl); Q64442 Sorbitol dehydrogenase 2 3777.775 5.48 NLCR C20(Carbamidomethyl); C30(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C6(Carbamidomethyl); EVDEYCKIGRYNLTPTIFFCATPPDDG Q64442 Sorbitol dehydrogenase K7(HeavyDimethyl); 3 3793.873 4.58 NLCR C20(Carbamidomethyl); C30(Carbamidomethyl) Isoform 3 of E3 EVEENWSKHFSSDAAPQPRFYCVLSTE N-Term(Dimethyl); K8(Dimethyl); A2AN08-3 ubiquitin-protein ligase 1 4183.895 2.93 ASEEDLNR C22(Carbamidomethyl) UBR4 Serum N-Term(Dimethyl:2H(6)13C(2)); EVESVDLPNCHLIK Q62086 paraoxonase/arylesterase C10(Carbamidomethyl); 2 1724.982 2.65 2 K14(HeavyDimethyl) Trifunctional enzyme EVESVTPEHCIFASNTSALPINQIAAVS N-Term(Dimethyl); Q8BMS1 subunit alpha, 1 3168.632 3.53 K C10(Carbamidomethyl); K29(Dimethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); EVESVTPEHCIFASNTSALPINQIAAVS Q8BMS1 subunit alpha, C10(Carbamidomethyl); 1 3184.714 3.88 K mitochondrial K29(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl); EVESVTPEHCIFASNTSALPINQIAAVS Q8BMS1 subunit alpha, C10(Carbamidomethyl); K29(Dimethyl); 6 3706.958 4.06 KRPEK mitochondrial K33(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme EVESVTPEHCIFASNTSALPINQIAAVS C10(Carbamidomethyl); Q8BMS1 subunit alpha, 2 3731.077 3.66 KRPEK K29(HeavyDimethyl); mitochondrial K33(HeavyDimethyl) Succinate-semialdehyde N-Term(Dimethyl); EVGEVLCTDPLVSK Q8BWF0 dehydrogenase, 1 1601.844 3.20 C7(Carbamidomethyl); K14(Dimethyl) mitochondrial

Succinate-semialdehyde N-Term(Dimethyl:2H(6)13C(2)); EVGEVLCTDPLVSK Q8BWF0 dehydrogenase, C7(Carbamidomethyl); 6 1617.930 3.69 mitochondrial K14(HeavyDimethyl) pre-mRNA 3' end EVGGMEMAHEGMIWSLAWHPLGHIL M5(Oxidation); M7(Oxidation); Q8K4P0 processing protein 1 3934.783 2.84 CSGSNDHTSK C26(Carbamidomethyl); K35(Dimethyl) WDR33 EVLLTCGEDTADRPQVPIFEYLGVKPG N-Term(Dimethyl); P24456 Cytochrome P450 2D10 1 4599.386 4.56 SQGVVLAPYGPEWR C6(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); EVLLTCGEDTADRPQVPIFEYLGVKPG P24456 Cytochrome P450 2D10 C6(Carbamidomethyl); 3 4615.456 5.21 SQGVVLAPYGPEWR K25(HeavyDimethyl) Serine/threonine-protein phosphatase 2A 56 kDa EVMFLGEIEEILDVIEPTQFK Q6PD03 M3(Oxidation); K21(Dimethyl) 1 2523.286 2.35 regulatory subunit alpha isoform N-Term(Dimethyl:2H(6)13C(2)); EVMLENYSNLASLGFPFTKPKMISVLQ K19(HeavyDimethyl); Q9QXT9 Zinc finger protein 354B 1 4055.281 3.22 QGEEPWK K21(HeavyDimethyl); K34(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); EVMSVSYASTNLEWLHGCPPPYHTFE Cytochrome c oxidase P00397 C18(Carbamidomethyl); 1 3840.879 3.43 EPTYVK subunit 1 K32(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); EVMSVSYASTNLEWLHGCPPPYHTFE Cytochrome c oxidase P00397 M3(Oxidation); C18(Carbamidomethyl); 1 3856.884 3.31 EPTYVK subunit 1 K32(HeavyDimethyl) Ral GTPase-activating EVMTFEDFAAQVFSPSPSYSVSGTGVL K36(HeavyDimethyl); F7CGP0 protein subunit alpha-2 1 4875.437 2.74 TSSLSMDPKKILHVEER K37(HeavyDimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); EVPQMCIPGKIEEVVLEAR F8VPN4 Protein Agl C6(Carbamidomethyl); 1 2269.296 2.74 K10(HeavyDimethyl) EVQVVQPTAEEAGSSPVDLSAGSSFPG N-Term(Dimethyl:2H(6)13C(2)); Q9D2H4 MAGEB3 1 3441.786 3.21 GSAPQGVK K35(HeavyDimethyl) C21(Carbamidomethyl); EVRSFLIVLLALLSVYITGVCVTFIVLF Immunoglobulin P0C6B7 K29(HeavyDimethyl); 1 3600.165 2.83 KSK superfamily member 6 K31(HeavyDimethyl) EVSLGGSSGGGGSSSSSSNFHISVEESV Keratin 15, isoform N-Term(Dimethyl:2H(6)13C(2)); B1AQ77 1 3527.786 2.61 DGKVVSSR CRA_a K31(HeavyDimethyl) Serum N-Term(Dimethyl); EVTPVELPNCNLVK H3BK03 paraoxonase/arylesterase 7 1667.898 3.43 C10(Carbamidomethyl); K14(Dimethyl) 1 (Fragment) Serum N-Term(Dimethyl:2H(6)13C(2)); EVTPVELPNCNLVK H3BK03 paraoxonase/arylesterase C10(Carbamidomethyl); 6 1683.990 3.31 1 (Fragment) K14(HeavyDimethyl) AT-rich interactive EVTRGLSLPTTITSAAFTLRTQYMK B7ZP08 domain-containing N-Term(Dimethyl); K25(Dimethyl) 1 2841.520 2.63 protein 3C Sodium/potassium- N-Term(Dimethyl); EVTVECHIAGTR P97370 transporting ATPase 1 1399.696 2.63 C6(Carbamidomethyl) subunit beta-3 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); EVTVECHIAGTR P97370 transporting ATPase 4 1407.744 2.97 C6(Carbamidomethyl) subunit beta-3 N-Term(Dimethyl); Vitamin D-binding C9(Carbamidomethyl); EVVSLTEECCAEGADPTCYDTR P21614 4 2590.066 5.27 protein C10(Carbamidomethyl); C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Vitamin D-binding C9(Carbamidomethyl); EVVSLTEECCAEGADPTCYDTR P21614 1 2598.116 5.14 protein C10(Carbamidomethyl); C18(Carbamidomethyl) N-Term(Dimethyl); EYCGVPGDGYEELIR Q07456 Protein AMBP 1 1784.809 2.72 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EYCGVPGDGYEELIR Q07456 Protein AMBP 3 1792.869 2.67 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); EYCGVPGDGYEELIRS Q07456 Protein AMBP 1 1879.880 2.94 C3(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); EYRDLTTAGAVTQCYR P62717 2 1939.977 2.28 L18a C14(Carbamidomethyl) EYSTLEELQKEFGAAGLGELFSECVLG MCG4676, isoform K10(Dimethyl); C24(Carbamidomethyl); Q3UYX7 1 3372.732 2.95 LVK CRA_a K30(Dimethyl) Ganglioside-induced EYVLVYFHTLTSDYNHLDSDFLK Q9DBL2 differentiation- K23(HeavyDimethyl) 1 2855.472 2.66 associated protein 2 Eukaryotic translation N-Term(Dimethyl); FACNGTVIEHPEYGEVIQLQGDQR J3QN87 initiation factor 1 1 2788.327 3.29 C3(Carbamidomethyl) (Fragment) Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); FACNGTVIEHPEYGEVIQLQGDQR J3QN87 initiation factor 1 2 2796.379 3.13 C3(Carbamidomethyl) (Fragment) Eukaryotic translation N-Term(Dimethyl); FACNGTVIEHPEYGEVIQLQGDQRK J3QN87 initiation factor 1 1 2944.462 2.99 C3(Carbamidomethyl); K25(Dimethyl) (Fragment) Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); FACNGTVIEHPEYGEVIQLQGDQRK J3QN87 initiation factor 1 C3(Carbamidomethyl); 1 2960.556 2.77 (Fragment) K25(HeavyDimethyl) N-Term(Dimethyl); FAELVYTGFWHSPECEFVR J3QNG0 MCG15755 33 2402.113 5.38 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FAELVYTGFWHSPECEFVR J3QNG0 MCG15755 43 2410.166 5.64 C15(Carbamidomethyl) FAKLCEEHGILRENIIDLSNANR P11589 Major urinary protein 2 K3(Dimethyl); C5(Carbamidomethyl) 1 2740.389 3.60 K3(HeavyDimethyl); FAKLCEEHGILRENIIDLSNANR P11589 Major urinary protein 2 1 2748.443 3.37 C5(Carbamidomethyl) FAPPEPAEPWSFVKHTTSYPPLCYQNP N-Term(Dimethyl); K14(Dimethyl); Q8VCC2 Liver carboxylesterase 1 1 3756.843 3.35 EAALR C23(Carbamidomethyl) Major urinary proteins N-Term(Dimethyl); FAQLCEEHGILRENIIDLSNANR A2BIN0 1 2740.386 3.89 11 and 8 C5(Carbamidomethyl) Major urinary proteins N-Term(Dimethyl:2H(6)13C(2)); FAQLCEEHGILRENIIDLSNANR A2BIN0 2 2748.444 3.00 11 and 8 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase K7(HeavyDimethyl); FAQTLEKVCVQTVESGAMTK P54071 4 2335.341 3.74 [NADP], mitochondrial C9(Carbamidomethyl); K20(HeavyDimethyl) Isobutyryl-CoA N-Term(Dimethyl); FASYCLTEPGSGSDAASLLTSAK Q9D7B6 dehydrogenase, 4 2389.168 4.45 C5(Carbamidomethyl); K23(Dimethyl) mitochondrial Isobutyryl-CoA N-Term(Dimethyl:2H(6)13C(2)); FASYCLTEPGSGSDAASLLTSAK Q9D7B6 dehydrogenase, C5(Carbamidomethyl); 1 2405.236 3.83 mitochondrial K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K13(HeavyDimethyl); FAVYLPPQAESGKCPALYWLSGLTCTE S-formylglutathione H3BJP2 C14(Carbamidomethyl); 3 3884.095 3.33 QNFISK hydrolase (Fragment) C25(Carbamidomethyl); K33(HeavyDimethyl) Isoform 2 of NADH dehydrogenase N-Term(Dimethyl); FCCEPAGGLTSLTEPPKGPGFGVQAGL Q9D6J6-2 [ubiquinone] C2(Carbamidomethyl); 1 2803.375 3.46 flavoprotein 2, C3(Carbamidomethyl); K17(Dimethyl) mitochondrial Electron transfer flavoprotein-ubiquinone N-Term(Dimethyl); FCPAGVYEFVPLEQGDGFR Q6PF96 5 2216.044 3.94 oxidoreductase, C2(Carbamidomethyl) mitochondrial

Electron transfer flavoprotein-ubiquinone N-Term(Dimethyl:2H(6)13C(2)); FCPAGVYEFVPLEQGDGFR Q6PF96 6 2224.074 3.90 oxidoreductase, C2(Carbamidomethyl) mitochondrial N-Term(Dimethyl); FCPSIEMR Q8VC12 Urocanate hydratase 1 1067.502 2.11 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FCPSIEMR Q8VC12 Urocanate hydratase 3 1075.542 2.13 C2(Carbamidomethyl) FCQEFQHYPAMGGVAPQALAVAASGP N-Term(Dimethyl); Q61838 Alpha-2-macroglobulin 4 3266.563 4.70 GSSFR C2(Carbamidomethyl) FCQEFQHYPAMGGVAPQALAVAASGP N-Term(Dimethyl); Q61838 Alpha-2-macroglobulin 1 3282.548 5.04 GSSFR C2(Carbamidomethyl); M11(Oxidation) FCQEFQHYPAMGGVAPQALAVAASGP N-Term(Dimethyl:2H(6)13C(2)); Q61838 Alpha-2-macroglobulin 5 3274.611 4.78 GSSFR C2(Carbamidomethyl) FCQEFQHYPAMGGVAPQALAVAASGP N-Term(Dimethyl:2H(6)13C(2)); Q61838 Alpha-2-macroglobulin 1 3290.609 4.69 GSSFR C2(Carbamidomethyl); M11(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); 3-oxo-5-beta-steroid 4- FCQQHDIVIVAHSPLGTCR Q8VCX1 C2(Carbamidomethyl); 2 2274.162 4.06 dehydrogenase C18(Carbamidomethyl) Phosphoenolpyruvate N-Term(Dimethyl:2H(6)13C(2)); FCTPASQCPIIDPAWESPEGVPIEGIIFG Q9Z2V4 carboxykinase, cytosolic C2(Carbamidomethyl); 1 3436.727 3.01 GR [GTP] C8(Carbamidomethyl) FDIQRDPLMDPSLK F8VQM0 Alkaline phosphatase K14(Dimethyl) 1 1702.882 2.17 Basic leucine zipper and N-Term(Dimethyl); FDPTQFQDCIIQGLTETGTDLEAVAK Q9CQC6 W2 domain-containing 1 2953.451 4.25 C9(Carbamidomethyl); K26(Dimethyl) protein 1 NADH dehydrogenase N-Term(Dimethyl); FDQCVLDKLGWVRPDLGQLSK Q9DCJ5 [ubiquinone] 1 alpha C4(Carbamidomethyl); K8(Dimethyl); 1 2558.393 3.22 subcomplex subunit 8 K21(Dimethyl) N-Term(Dimethyl); FDTGNLCMVTGGANLGR Q3V1Z5 Protein Rps4l 2 1810.854 3.13 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FDTGNLCMVTGGANLGR Q3V1Z5 Protein Rps4l 1 1818.915 2.42 C7(Carbamidomethyl) Isoform Short of N-Term(Dimethyl); FEEGGYVVCNTK O08573-2 9 1458.690 3.61 Galectin-9 C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of FEEGGYVVCNTK O08573-2 C9(Carbamidomethyl); 3 1474.777 2.27 Galectin-9 K12(HeavyDimethyl) Isoform Short of N-Term(Dimethyl); FEEGGYVVCNTKQNGQWGPEER O08573-2 1 2640.210 2.84 Galectin-9 C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of FEEGGYVVCNTKQNGQWGPEER O08573-2 C9(Carbamidomethyl); 3 2656.309 3.90 Galectin-9 K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); FEKNGIKHVHAFIHTPTGTHFCEVEQM K3(HeavyDimethyl); D3Z4U1 Uricase 1 3458.867 3.44 R K7(HeavyDimethyl); C22(Carbamidomethyl) N-Term(Dimethyl); FELTCYSLAPQIK J3QNG0 MCG15755 16 1625.862 4.72 C5(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FELTCYSLAPQIK J3QNG0 MCG15755 C5(Carbamidomethyl); 15 1641.952 5.45 K13(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); FELTCYSLAPQIKVIAPWR J3QNG0 MCG15755 C5(Carbamidomethyl); 2 2364.383 2.94 K13(HeavyDimethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); FFASSNLHHVSECTQMSHLGCMHYTV Q8BH00 dehydrogenase family 8 C13(Carbamidomethyl); 1 3272.501 2.99 R member A1 C21(Carbamidomethyl)

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); FFESYHEVPDGTQCHR Q9D8B4 [ubiquinone] 1 alpha 1 2044.929 2.55 C14(Carbamidomethyl) subcomplex subunit 11

Isoform 2 of Meiosis FFPAVPLPDIRSLQQPK Q8BJ34-2 K17(HeavyDimethyl) 1 1989.165 2.49 arrest female protein 1 Glutamate N-Term(Dimethyl); K4(Dimethyl); FGAKCVGVGESDGSIWNPDGIDPK P26443 dehydrogenase 1, 1 2589.253 3.02 C5(Carbamidomethyl); K24(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Glutamate K4(HeavyDimethyl); FGAKCVGVGESDGSIWNPDGIDPK P26443 dehydrogenase 1, 1 2613.400 3.36 C5(Carbamidomethyl); mitochondrial K24(HeavyDimethyl) N-Term(Dimethyl); FGCQVAGKK P97328 Ketohexokinase C3(Carbamidomethyl); K8(Dimethyl); 1 1078.605 2.25 K9(Dimethyl) Arginine--tRNA ligase, N-Term(Dimethyl); FGDYQCNSAMGISQMLK Q9D0I9 1 2005.920 2.65 cytoplasmic C6(Carbamidomethyl); K17(Dimethyl) Isoform Mt-VDAC1 of Voltage-dependent anion-N-Term(Dimethyl); K6(Dimethyl); FGIAAKYQVDPDACFSAK Q60932-2 2 2072.045 3.12 selective channel protein C14(Carbamidomethyl); K18(Dimethyl) 1 D-beta-hydroxybutyrate N-Term(Dimethyl); FGIEAFSDCLR Q80XN0 dehydrogenase, 2 1342.646 2.29 C9(Carbamidomethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); FGIEAFSDCLR Q80XN0 dehydrogenase, 1 1350.693 2.08 C9(Carbamidomethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl); FGIEAFSDCLRYEMHPLGVK Q80XN0 dehydrogenase, 1 2425.204 2.89 C9(Carbamidomethyl); K20(Dimethyl) mitochondrial D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); FGIEAFSDCLRYEMHPLGVK Q80XN0 dehydrogenase, C9(Carbamidomethyl); 2 2441.295 3.65 mitochondrial K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein FGIICMEDLIHEIYTVGKR P14148 C5(Carbamidomethyl); 3 2366.332 3.78 L7 K18(HeavyDimethyl) Isoform 2 of 2- oxoglutarate N-Term(Dimethyl); FGLEGCEVLIPALK Q60597-2 2 1601.893 2.87 dehydrogenase, C6(Carbamidomethyl); K14(Dimethyl) mitochondrial Isoform 2 of 2- N-Term(Dimethyl:2H(6)13C(2)); oxoglutarate FGLEGCEVLIPALK Q60597-2 C6(Carbamidomethyl); 2 1617.970 2.74 dehydrogenase, K14(HeavyDimethyl) mitochondrial Selenide, water dikinase N-Term(Dimethyl); FGLLQGTSAETSGGLLICLPR P97364 1 2218.188 4.50 2 C18(Carbamidomethyl) Isoform L10 of FGMKGPASVISNDDDSASPLHHISNGS K4(HeavyDimethyl); M44(Oxidation); P15209-4 BDNF/NT-3 growth 1 4670.225 3.69 NTPSSSEGGPDAVIIGMTK K46(HeavyDimethyl) factors receptor Transitional N-Term(Dimethyl); K7(Dimethyl); FGMTPSKGVLFYGPPGCGK Q01853 endoplasmic reticulum 2 2084.059 3.12 C17(Carbamidomethyl); K19(Dimethyl) ATPase N-Term(Dimethyl:2H(6)13C(2)); Transitional K7(HeavyDimethyl); FGMTPSKGVLFYGPPGCGK Q01853 endoplasmic reticulum 1 2108.198 2.66 C17(Carbamidomethyl); ATPase K19(HeavyDimethyl)

Thrombospondin type-1 K4(Dimethyl); M6(Oxidation); FGYKLMMAPEVTCESVLEVMVLPPPC G3XA27 domain-containing M7(Oxidation); C13(Carbamidomethyl); 1 4289.159 3.21 VFVQGVLAVYK protein 1 C26(Carbamidomethyl); K37(Dimethyl)

FHDFLGDSWGILFSHPRDFTPVCTTEL N-Term(Dimethyl); O08709 Peroxiredoxin-6 1 3435.634 3.23 GR C23(Carbamidomethyl) FHDFLGDSWGILFSHPRDFTPVCTTEL N-Term(Dimethyl:2H(6)13C(2)); O08709 Peroxiredoxin-6 2 3443.715 4.21 GR C23(Carbamidomethyl) ADP-ribosylation factor- N-Term(Dimethyl:2H(6)13C(2)); FHEICSNLVK Q9JKW0 like protein 6-interacting C5(Carbamidomethyl); 1 1318.775 2.33 protein 1 K10(HeavyDimethyl) FHGASRVMGTNDGKALLPAVR P22727 Protein Wnt-6 K14(Dimethyl) 1 2225.191 2.26 FHSPTCAVPFTHEDTAPEEEEEEEEEEE Isoform 2 of Protein N-Term(Dimethyl); A1L3C1-2 1 4003.665 3.11 EEEVK FAM71E1 C6(Carbamidomethyl); K33(Dimethyl) 2-amino-3-ketobutyrate N-Term(Dimethyl:2H(6)13C(2)); FICGTQSIHK E9PWY6 coenzyme A ligase, C3(Carbamidomethyl); 1 1262.750 2.29 mitochondrial K10(HeavyDimethyl)

2-amino-3-ketobutyrate N-Term(Dimethyl); FICGTQSIHKNLEAK E9PWY6 coenzyme A ligase, C3(Carbamidomethyl); K10(Dimethyl); 7 1829.989 3.71 mitochondrial K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-amino-3-ketobutyrate C3(Carbamidomethyl); FICGTQSIHKNLEAK E9PWY6 coenzyme A ligase, 4 1854.123 3.46 K10(HeavyDimethyl); mitochondrial K15(HeavyDimethyl) N-Term(Dimethyl); FIDLLPTSLPHAVTCDIK Q3UT49 Cytochrome P450 2C29 1 2096.152 2.45 C15(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FIDLLPTSLPHAVTCDIK Q3UT49 Cytochrome P450 2C29 C15(Carbamidomethyl); 2 2112.221 3.27 K18(HeavyDimethyl) N-Term(Dimethyl); FIDLLPTSLPHAVTCDIKFR Q3UT49 Cytochrome P450 2C29 1 2399.319 3.04 C15(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FIDLVPNNLPHEVTCDIK Q6XVG2 Cytochrome P450 2C54 C15(Carbamidomethyl); 2 2196.233 3.23 K18(HeavyDimethyl) N-Term(Dimethyl); FIDLVPNNLPHEVTCDIKFR Q6XVG2 Cytochrome P450 2C54 1 2483.326 2.88 C15(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FIDLVPNNLPHEVTCDIKFR Q6XVG2 Cytochrome P450 2C54 C15(Carbamidomethyl); 2 2499.405 2.76 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of FIDLVPNSLPHEVTCDIK Q91X77-2 C15(Carbamidomethyl); 1 2169.225 2.72 Cytochrome P450 2C50 K18(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); FIDLVPNSLPHEVTCDIKFR Q91X77-2 1 2456.309 2.68 Cytochrome P450 2C50 C15(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of FIDLVPNSLPHEVTCDIKFR Q91X77-2 C15(Carbamidomethyl); 2 2472.396 3.45 Cytochrome P450 2C50 K18(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); K8(Dimethyl); FIMESGAKGCEVVVSGK D3YV43 3 1881.971 3.89 S3 C10(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein K8(HeavyDimethyl); FIMESGAKGCEVVVSGK D3YV43 1 1906.114 4.24 S3 C10(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl); Protein disulfide- FIQDSIFGLCPHMTEDNKDLIQGK P27773 C10(Carbamidomethyl); K18(Dimethyl); 1 2890.458 3.10 isomerase A3 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein disulfide- C10(Carbamidomethyl); FIQDSIFGLCPHMTEDNKDLIQGK P27773 1 2914.582 2.95 isomerase A3 K18(HeavyDimethyl); K24(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); FIQQTYPSGGEEQAQYCR Q9WU78-2 Programmed cell death 6- 7 2189.986 4.72 C17(Carbamidomethyl) interacting protein Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); FIQQTYPSGGEEQAQYCR Q9WU78-2 Programmed cell death 6- 6 2198.025 5.00 C17(Carbamidomethyl) interacting protein N-Term(Dimethyl); K2(Dimethyl); FKGDQELQEIVSCIENFPSAFPR A2A977 Cytochrome P450 4A10 1 2767.382 3.27 C13(Carbamidomethyl) Brain-specific C3(Carbamidomethyl); K21(Dimethyl); FLCLGWGLPALVVAISVGFTKAK E9Q4H5 1 2503.420 2.31 angiogenesis inhibitor 1 K23(Dimethyl) Gamma- N-Term(Dimethyl:2H(6)13C(2)); FLDDFEDCPSMYQR E0CZ04 glutamylaminecyclotrans 1 1858.836 2.29 C8(Carbamidomethyl) ferase (Fragment) Guanine nucleotide- FLDDNQIITSSGDTTCALWDIETGQQT binding protein N-Term(Dimethyl:2H(6)13C(2)); D3Z1T4 1 4138.847 2.95 VGFAGHSGDVM G(I)/G(S)/G(T) subunit C16(Carbamidomethyl); M38(Oxidation) beta-2 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); FLEETNCLYAAEGQR F6UV36 Cullin-4A (Fragment) 1 1836.894 2.61 C7(Carbamidomethyl) FLGPEIFFHPEFANPDFTQPISEVVDEVI N-Term(Dimethyl); Q99JY9 Actin-related protein 3 1 4344.164 3.03 QNCPIDVR C32(Carbamidomethyl) Eukaryotic translation FLHDHVDLQVSALYALQVHCYNSSFP C20(Carbamidomethyl); F6UU81 initiation factor 4 1 3810.929 3.06 KGMLLR K27(HeavyDimethyl); M29(Oxidation) gamma 2 (Fragment) Selenium-binding FLHDPSATQGFVGCALSSNIQR G3UYY2 C14(Carbamidomethyl) 12 2405.158 4.22 protein 2 Selenium-binding N-Term(Dimethyl); FLHDPSATQGFVGCALSSNIQR G3UYY2 23 2433.191 5.88 protein 2 C14(Carbamidomethyl) Selenium-binding N-Term(Dimethyl:2H(6)13C(2)); FLHDPSATQGFVGCALSSNIQR G3UYY2 17 2441.240 5.72 protein 2 C14(Carbamidomethyl) FLKSGDAAIVDMVPGKPMCVESFSDY Elongation factor 1- N-Term(Dimethyl); K3(Dimethyl); P10126 5 3467.735 4.86 PPLGR alpha 1 K16(Dimethyl); C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FLKSGDAAIVDMVPGKPMCVESFSDY Elongation factor 1- K3(HeavyDimethyl); P10126 2 3491.876 5.51 PPLGR alpha 1 K16(HeavyDimethyl); C19(Carbamidomethyl) Isoform 2 of DDB1- and N-Term(Dimethyl); FLPNSGDSTLAMCAR Q8N7N5-2 CUL4-associated factor 1 1667.787 2.39 C13(Carbamidomethyl) 8 Isoform 2 of DDB1- and N-Term(Dimethyl:2H(6)13C(2)); FLPNSGDSTLAMCAR Q8N7N5-2 CUL4-associated factor 1 1675.830 2.13 C13(Carbamidomethyl) 8 FLQDKDFLVGPHISLADLVAITELMHP Glutathione S- N-Term(Dimethyl); K5(Dimethyl); D3Z3X5 2 4425.310 3.43 VGGGCPVFEGHPR transferase theta-1 C32(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FLQDKDFLVGPHISLADLVAITELMHP Glutathione S- D3Z3X5 K5(HeavyDimethyl); 1 4441.418 4.04 VGGGCPVFEGHPR transferase theta-1 C32(Carbamidomethyl) N-Term(Dimethyl); Cystathionine gamma- C15(Carbamidomethyl); FLQNSLGAVPSPFDCYLCCR Q8VCN5 1 2432.150 3.30 lyase C18(Carbamidomethyl); C19(Carbamidomethyl) N-Term(Dimethyl); K9(Dimethyl); Glutathione S- FLQPGSQRKPFDDAKCVESAK P30115 K15(Dimethyl); C16(Carbamidomethyl); 3 2520.315 3.42 transferase A3 K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K9(HeavyDimethyl); Glutathione S- FLQPGSQRKPFDDAKCVESAK P30115 K15(HeavyDimethyl); 2 2552.491 2.75 transferase A3 C16(Carbamidomethyl); K21(HeavyDimethyl) Acyl-CoA synthetase N-Term(Dimethyl); FLSCYDPINIQFTSGTTGNPK Q8VCW8 family member 2, 9 2416.186 5.53 C4(Carbamidomethyl); K21(Dimethyl) mitochondrial Acyl-CoA synthetase N-Term(Dimethyl:2H(6)13C(2)); FLSCYDPINIQFTSGTTGNPK Q8VCW8 family member 2, C4(Carbamidomethyl); 8 2432.278 6.18 mitochondrial K21(HeavyDimethyl) Isoform 2 of Rho FLSLEYSPVGKEYVRQLVYVEQAGSSP P59281-2 GTPase-activating K11(Dimethyl); K28(Dimethyl) 1 3229.755 3.14 K protein 39 28S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); FLSNCNPEQLERLCASL G3UWM7 S29, mitochondrial C5(Carbamidomethyl); 1 2087.046 3.00 (Fragment) C14(Carbamidomethyl) FLSSPLLILHGEDDRTVPLEFGKQLYEI N-Term(Dimethyl:2H(6)13C(2)); S4R2K4 Protein Abhd12b 1 3528.954 2.61 AR K23(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); K7(Dimethyl); FLVHNVKELEVLLMCNK P62911 3 2170.212 2.71 L32 C15(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein K7(HeavyDimethyl); FLVHNVKELEVLLMCNK P62911 3 2194.350 3.28 L32 C15(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); FLYECPWR G5E8R3 Pyruvate carboxylase 1 1206.615 1.92 C5(Carbamidomethyl) Helicase with zinc finger FLYEEEAAQQQLVAK A2AS05 N-Term(Dimethyl); K15(Dimethyl) 1 1822.950 2.23 domain 2 Ras-related protein Rab- N-Term(Dimethyl); FMADCPHTIGVEFGTR A2AL34 2 1865.863 3.21 14 C5(Carbamidomethyl) Ras-related protein Rab- N-Term(Dimethyl:2H(6)13C(2)); FMADCPHTIGVEFGTR A2AL34 1 1873.893 2.55 14 C5(Carbamidomethyl) FMGMSVGVSMIGEGVLRLLDHGEEYV Oxysterol-binding N-Term(Dimethyl:2H(6)13C(2)); Q8R2T7 1 3883.975 2.92 FTLPSAYAR protein M10(Oxidation) M2(Oxidation); M3(Oxidation); FMMKTAQGGGHRTLLYGHAILLR E9Q401 Ryanodine receptor 2 1 2639.409 2.67 K4(HeavyDimethyl) NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); FMPIVYTPTVGLACQQYSLAFR P06801 1 2598.371 2.78 enzyme C14(Carbamidomethyl) FMSQRAYGLMMATTSR E9Q5N7 Protein Nrxn2 N-Term(Dimethyl); M11(Oxidation) 1 1894.913 2.20 N-Term(Dimethyl); FMTVLCTR F8WIT2 Annexin 1 1055.535 2.24 C6(Carbamidomethyl) FNIRMGFNTLNSLISNNSKQTSHAITLQ MLX-interacting protein M5(Oxidation); K19(Dimethyl); F6UPM1 2 3349.725 3.33 K (Fragment) K29(Dimethyl) Trifunctional enzyme N-Term(Dimethyl); FNIWGGSLSLGHPFGATGCR Q99JY0 subunit beta, 4 2162.067 4.04 C19(Carbamidomethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); FNIWGGSLSLGHPFGATGCR Q99JY0 subunit beta, 3 2170.118 3.56 C19(Carbamidomethyl) mitochondrial FNLLREENEGYAKLIAELGQDLSGNITS K13(HeavyDimethyl); B1AZI6 THO complex subunit 2 1 4105.296 2.88 DLILENIK K36(HeavyDimethyl) Alpha-aminoadipic N-Term(Dimethyl); FNTDIAPYTTCLINGIYWEQNTPR Q99K67 semialdehyde synthase, 3 2915.423 4.77 C11(Carbamidomethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); FNTDIAPYTTCLINGIYWEQNTPR Q99K67 semialdehyde synthase, 4 2923.463 4.96 C11(Carbamidomethyl) mitochondrial FPLMEAEVLQRLHDKLGPSPLR Q99JN2 Kelch-like protein 22 M4(Oxidation); K15(HeavyDimethyl) 1 2598.467 2.77 FQAQGGPSPLKNNSDSAKLPISSGSTSS G-protein coupled N-Term(Dimethyl); K11(Dimethyl); Q8K209 1 3089.610 2.58 SR receptor 56 K18(Dimethyl) FQEHLQLQNLGINPANIGFSTLTMESD N-Term(Dimethyl); K28(Dimethyl); Q68FD5 Clathrin heavy chain 1 1 3890.954 3.07 KFICIR C31(Carbamidomethyl) Homeobox protein FQGNDTSPESFLLHNALAR Q04744 N-Term(Dimethyl) 1 2145.054 3.11 EMX2 FQIDPNSGEVRTKGELDYEER Q91Y17 Protein Pcdha9 K13(Dimethyl) 4 2510.220 2.70 FQLLYVSCGMVHLLSPELGACVAPGG Dynein assembly factor C8(Carbamidomethyl); Q3UYV8 1 4682.540 2.93 NLVVELARYLVDLRPK 3, axonemal C21(Carbamidomethyl); K42(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cysteine sulfinic acid FQRYPDCK Q9DBE0 C7(Carbamidomethyl); 1 1185.666 1.98 decarboxylase K8(HeavyDimethyl) FQSAAIGALQEASEAYLVGLFEDTNLC N-Term(Dimethyl); E0CZ27 Histone H3 (Fragment) 5 3493.797 6.88 AIHAK C27(Carbamidomethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FQSAAIGALQEASEAYLVGLFEDTNLC E0CZ27 Histone H3 (Fragment) C27(Carbamidomethyl); 2 3509.854 6.47 AIHAK K32(HeavyDimethyl) FQSAAIGALQEASEAYLVGLFEDTNLC N-Term(Dimethyl); E0CZ27 Histone H3 (Fragment) 2 3649.870 4.73 AIHAKR C27(Carbamidomethyl); K32(Dimethyl) C8(Carbamidomethyl); FQTLFQPCNWMGAMRLIEDFTQVSIDC C27(Carbamidomethyl); E9Q507 GON-4-like protein 1 4129.067 3.86 SPHKTAK K31(HeavyDimethyl); K34(HeavyDimethyl) N-Term(Dimethyl); FRCPEALFQPSFLGMESCGIHETTFNSI E9Q1F2 Actin, cytoplasmic 1 C3(Carbamidomethyl); 1 3590.744 3.78 MK C18(Carbamidomethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FRCPEALFQPSFLGMESCGIHETTFNSI C3(Carbamidomethyl); E9Q1F2 Actin, cytoplasmic 1 2 3606.795 5.03 MK C18(Carbamidomethyl); K30(HeavyDimethyl) Succinate-semialdehyde N-Term(Dimethyl:2H(6)13C(2)); FRNAGQTCVCSNR Q8BWF0 dehydrogenase, C8(Carbamidomethyl); 2 1605.776 2.71 mitochondrial C10(Carbamidomethyl) EF-hand calcium- N-Term(Dimethyl); M4(Oxidation); FRTMESNQKSSFQEIPK A2A8T9 binding domain- 1 2157.074 2.42 K9(Dimethyl); K17(Dimethyl) containing protein 14 FSAPLPPQPWEGVRDASINPPMCLQDV N-Term(Dimethyl); Q8VCU1 Carboxylesterase 3B 3 3334.639 4.10 EK C23(Carbamidomethyl); K29(Dimethyl) FSAPLPPQPWEGVRDASINPPMCLQDV Isoform 2 of N-Term(Dimethyl); Q63880-2 4 3334.628 3.89 ER Carboxylesterase 3A C23(Carbamidomethyl) FSAPLPPQPWEGVRDASINPPMCLQDV Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); Q63880-2 2 3342.677 3.32 ER Carboxylesterase 3A C23(Carbamidomethyl) Very-long-chain (3R)-3- hydroxyacyl-[acyl- N-Term(Dimethyl:2H(6)13C(2)); FSFFLQVYLVMLFLGLYINFR Q8K2C9 1 2682.524 2.50 carrier protein] M11(Oxidation) dehydratase 3 Isoform 3 of Tumor FSGAPAMMEGSWLDVAQRGKPEAQPF M7(Oxidation); K20(HeavyDimethyl); O35235-3 necrosis factor ligand 1 4480.323 3.12 AHLTINAASIPSGSHK K42(HeavyDimethyl) superfamily member 11

Protein NipSnap N-Term(Dimethyl); FSGGYPALMDCMNK Q5SVG6 2 1646.730 2.33 homolog 1 (Fragment) C11(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein NipSnap FSGGYPALMDCMNK Q5SVG6 C11(Carbamidomethyl); 1 1662.817 2.32 homolog 1 (Fragment) K14(HeavyDimethyl) N-Term(Dimethyl); Protein NipSnap FSGGYPALMDCMNKLK Q5SVG6 C11(Carbamidomethyl); K14(Dimethyl); 1 1915.957 2.84 homolog 1 (Fragment) K16(Dimethyl) Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); FSHQGVQLIDFSPCER Q8JZQ9 initiation factor 3 2 1955.986 2.44 C14(Carbamidomethyl) subunit B Isoform 2 of Zinc finger FSKDLGSGRPVADAPASLASGAPEQDE D2EAC2-2 BED domain-containing K3(Dimethyl); K37(Dimethyl) 1 3874.921 3.19 ESLFEGNIEK protein 6 Glycoprotein endo-alpha- FSKERMTYALDQQQPAS Q6NXH2 N-Term(Dimethyl); K3(Dimethyl) 2 2056.016 2.68 1,2-mannosidase M5(Oxidation); K14(HeavyDimethyl); FSLLMVVLSLIFMKGYCIR Q9QZ04 MAGE-like protein 2 2 2342.289 2.41 C17(Carbamidomethyl) Isoform FSMVIDNGIVKALNVEPDGTGLTCSLA Cytoplasmic+peroxisom N-Term(Dimethyl); K11(Dimethyl); P99029-2 3 3642.920 4.36 PNILSQL al of Peroxiredoxin-5, C24(Carbamidomethyl) mitochondrial Isoform FSMVIDNGIVKALNVEPDGTGLTCSLA Cytoplasmic+peroxisom N-Term(Dimethyl); M3(Oxidation); P99029-2 2 3658.915 3.98 PNILSQL al of Peroxiredoxin-5, K11(Dimethyl); C24(Carbamidomethyl) mitochondrial Isoform N-Term(Dimethyl:2H(6)13C(2)); FSMVIDNGIVKALNVEPDGTGLTCSLA Cytoplasmic+peroxisom P99029-2 K11(HeavyDimethyl); 3 3659.005 4.39 PNILSQL al of Peroxiredoxin-5, C24(Carbamidomethyl) mitochondrial Isoform N-Term(Dimethyl:2H(6)13C(2)); FSMVIDNGIVKALNVEPDGTGLTCSLA Cytoplasmic+peroxisom P99029-2 M3(Oxidation); K11(HeavyDimethyl); 2 3675.021 4.30 PNILSQL al of Peroxiredoxin-5, C24(Carbamidomethyl) mitochondrial Epidermal growth factor N-Term(Dimethyl); FSNNPILCNMDTIQWR Q01279 3 2036.974 2.78 receptor C8(Carbamidomethyl) FSPEVPGQKILHHRSDVLETVVLINPSD Microtubule-associated N-Term(Dimethyl:2H(6)13C(2)); P14873 1 4070.198 3.12 EAVSTEVR protein 1B K9(HeavyDimethyl) Na(+)/H(+) exchange N-Term(Dimethyl); FSPLLYCQSQELPNGSVK Q9JIL4 regulatory cofactor NHE- 3 2123.086 4.46 C7(Carbamidomethyl); K18(Dimethyl) RF3 Guanine nucleotide- N-Term(Dimethyl); FSPNSSNPIIVSCGWDK P68040 binding protein subunit 3 1963.956 3.20 C13(Carbamidomethyl); K17(Dimethyl) beta-2-like 1 Guanine nucleotide- N-Term(Dimethyl:2H(6)13C(2)); FSPNSSNPIIVSCGWDK P68040 binding protein subunit C13(Carbamidomethyl); 6 1980.045 2.97 beta-2-like 1 K17(HeavyDimethyl) Guanine nucleotide- N-Term(Dimethyl); FSPNSSNPIIVSCGWDKLVK P68040 binding protein subunit C13(Carbamidomethyl); K17(Dimethyl); 1 2332.241 3.35 beta-2-like 1 K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Guanine nucleotide- C13(Carbamidomethyl); FSPNSSNPIIVSCGWDKLVK P68040 binding protein subunit 1 2356.373 3.26 K17(HeavyDimethyl); beta-2-like 1 K20(HeavyDimethyl) FSSSSGSGASDPSDSLTAALRSATELRA F6ZED4 Protein Gm9970 N-Term(Dimethyl) 1 3193.604 3.07 PPSR N-Term(Dimethyl); FSVCVLGDQQHCDEAK Q5XJF6 Ribosomal protein C4(Carbamidomethyl); 6 1948.882 4.28 C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); FSVCVLGDQQHCDEAK Q5XJF6 Ribosomal protein 7 1964.973 5.20 C12(Carbamidomethyl); K16(HeavyDimethyl) FSVFPWLPLTTTDR Q8R4Y8-2 Isoform 2 of Rotatin 1 1679.858 2.51 N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); FTGQHFCGGTLIAPEWVLTAAHCLEK P20918 Plasminogen 1 3015.575 3.59 C23(Carbamidomethyl); K26(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); FTLDCTHPVEDGIMDAANFEQFLQER P67984 3 3111.422 4.16 L22 C5(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); FTLDCTHPVEDGIMDAANFEQFLQER P67984 2 3119.487 4.43 L22 C5(Carbamidomethyl) N-Term(Dimethyl); FTLSCTETLMSELGNIAK D3YU09 Guanine deaminase 1 2071.050 2.74 C5(Carbamidomethyl); K18(Dimethyl) K6(Dimethyl); K16(Dimethyl); FTNNSKLFPNTSDTPKENK A2AHK7 Mucin-15 1 2266.152 2.44 K19(Dimethyl) N-Term(Dimethyl); FTRGDDILLSPCFQR P58710 L-gulonolactone oxidase 3 1852.931 2.83 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FTRGDDILLSPCFQR P58710 L-gulonolactone oxidase 4 1860.980 3.35 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FTRMSPMSMGPPTPMPPFSPSPSGSTS Isoform 2 of Paternally- M9(Oxidation); M15(Oxidation); Q3URU2-2 1 3611.721 2.86 HCTNAK expressed gene 3 protein C29(Carbamidomethyl); K33(HeavyDimethyl) Malate dehydrogenase, N-Term(Dimethyl); K12(Dimethyl); FVFSLVDAMNGKEGVVECSFVQSK P08249 5 2761.405 3.33 mitochondrial C18(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, K12(HeavyDimethyl); FVFSLVDAMNGKEGVVECSFVQSK P08249 1 2785.532 3.28 mitochondrial C18(Carbamidomethyl); K24(HeavyDimethyl) N-Term(Dimethyl); FVFTPHMEAECLSESTALQK P19096 Fatty acid synthase 1 2381.151 4.36 C11(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); FVFTPHMEAECLSESTALQK P19096 Fatty acid synthase C11(Carbamidomethyl); 2 2397.239 3.13 K20(HeavyDimethyl) Eukaryotic peptide chain release factor GTP- N-Term(Dimethyl); K3(Dimethyl); FVKQDQVCIAR F7CE88 1 1419.771 2.47 binding subunit ERF3A C8(Carbamidomethyl) (Fragment) N-Term(Dimethyl); Eukaryotic translation FVLCPECENPETDLHVNPK P59325 C4(Carbamidomethyl); 5 2354.109 3.38 initiation factor 5 C7(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Eukaryotic translation C4(Carbamidomethyl); FVLCPECENPETDLHVNPK P59325 2 2370.187 2.66 initiation factor 5 C7(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl); FVLPANAFASPLQNPDNHCFCTEK Q08857 Platelet glycoprotein 4 C19(Carbamidomethyl); 2 2833.354 3.17 C21(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C19(Carbamidomethyl); FVLPANAFASPLQNPDNHCFCTEK Q08857 Platelet glycoprotein 4 1 2849.447 4.10 C21(Carbamidomethyl); K24(HeavyDimethyl) Malignant T-cell- N-Term(Dimethyl); FVLSGANIMCPGLTSPGAK Q9CQ21 1 1976.028 2.96 amplified sequence 2 C10(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malignant T-cell- FVLSGANIMCPGLTSPGAK Q9CQ21 C10(Carbamidomethyl); 1 1992.129 3.64 amplified sequence 2 K19(HeavyDimethyl) N-Term(Dimethyl); FVNRSPSPFHVVAECR Q9Z2W0 Aspartyl aminopeptidase 5 1929.974 3.17 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FVNRSPSPFHVVAECR Q9Z2W0 Aspartyl aminopeptidase 4 1938.010 2.57 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FVPFAAVAAANCINIPLMR Q3U4F0 Sideroflexin-3 2 2111.178 2.68 C12(Carbamidomethyl) FVVDSLSELQGFIKQTNAGLQR E9Q7N9 Protein Dnah11 K14(HeavyDimethyl) 1 2486.348 2.60 N-Term(Dimethyl:2H(6)13C(2)); 26S protease regulatory FVVDVDKNIDINDVTPNCR Q8K1K2 K7(HeavyDimethyl); 1 2305.248 2.62 subunit 8 C18(Carbamidomethyl) 1-phosphatidylinositol 4,5-bisphosphate FVVYEEDMFSDPNFLAHATYPIK Q8CIH5 K23(Dimethyl) 1 2761.319 2.46 phosphodiesterase gamma-2 Peroxisomal N-Term(Dimethyl); FVYEGSADFSCLPTFGVIVAQK P51660 multifunctional enzyme 5 2491.263 5.98 C11(Carbamidomethyl); K22(Dimethyl) type 2 Peroxisomal N-Term(Dimethyl:2H(6)13C(2)); FVYEGSADFSCLPTFGVIVAQK P51660 multifunctional enzyme C11(Carbamidomethyl); 9 2507.347 6.12 type 2 K22(HeavyDimethyl) Acylpyruvase FAHD1, FWEWGKNIVCVGR Q8R0F8 K6(Dimethyl); C10(Carbamidomethyl) 1 1678.853 2.61 mitochondrial K7(HeavyDimethyl); FWGLMAKVSSGTKMTDGNLSTSMNG TBC1 domain family D3YVW3 K13(HeavyDimethyl); M14(Oxidation); 1 3765.897 3.15 VALMGILDGR member 14 (Fragment) M23(Oxidation); M29(Oxidation) N-Term(Dimethyl); FYDPCEGMVTLDGHDIR J3QNY6 Bile salt export pump 8 2052.907 3.51 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); FYDPCEGMVTLDGHDIR J3QNY6 Bile salt export pump 3 2060.957 3.27 C5(Carbamidomethyl) FYEDQYGVSLFNSMRHEIEGTGPPQAQ Niban-like protein 1 A2ARS6 M14(Oxidation); K32(HeavyDimethyl) 1 3848.967 3.05 LLWRK (Fragment) N-Term(Dimethyl); K9(Dimethyl); FYMHHSFTKFNRNIISPTALFLAAK E9QAF8 Protein Ccnt2 1 3038.617 2.79 K25(Dimethyl) Armadillo repeat- FYRAASQGMLLPDR E0CZ41 containing protein 2 1 1624.813 2.06 (Fragment) N-Term(Dimethyl); Dickkopf-related protein GAAGVGGVQICLACR O54908 C11(Carbamidomethyl); 1 1516.771 2.32 1 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Dickkopf-related protein GAAGVGGVQICLACR O54908 C11(Carbamidomethyl); 2 1524.817 2.28 1 C14(Carbamidomethyl) Isoform 3 of Collagen N-Term(Dimethyl:2H(6)13C(2)); GADFQCFQQAR P39061-2 2 1363.656 2.37 alpha-1(XVIII) chain C6(Carbamidomethyl) Hydrocephalus-inducing N-Term(Dimethyl); M14(Oxidation); GAEGGLDFGTLRVMEEVK Q80W93 1 1979.996 2.32 protein K18(Dimethyl) Dimethylarginine K10(Dimethyl); K26(Dimethyl); GAEILADTFKDYAVSTVPVADSLHLKS D3YU15 dimethylaminohydrolase C29(Carbamidomethyl); 1 4996.505 3.09 FCSMAGPNLIAIGSSESAQK 1, isoform CRA_a M31(Oxidation); K47(Dimethyl) NADH dehydrogenase [ubiquinone] N-Term(Dimethyl); GAGAYICGEETALIESIEGK D3Z1U9 1 2124.057 3.67 flavoprotein 1, C7(Carbamidomethyl); K20(Dimethyl) mitochondrial

4- N-Term(Dimethyl); GALMANFLTQGQVCCNGTR Q9JLJ2 trimethylaminobutyralde C14(Carbamidomethyl); 3 2125.987 4.73 hyde dehydrogenase C15(Carbamidomethyl)

4- N-Term(Dimethyl); M4(Oxidation); GALMANFLTQGQVCCNGTR Q9JLJ2 trimethylaminobutyralde C14(Carbamidomethyl); 3 2141.974 4.67 hyde dehydrogenase C15(Carbamidomethyl)

4- N-Term(Dimethyl:2H(6)13C(2)); GALMANFLTQGQVCCNGTR Q9JLJ2 trimethylaminobutyralde C14(Carbamidomethyl); 6 2134.044 6.08 hyde dehydrogenase C15(Carbamidomethyl)

4- N-Term(Dimethyl:2H(6)13C(2)); GALMANFLTQGQVCCNGTR Q9JLJ2 trimethylaminobutyralde M4(Oxidation); C14(Carbamidomethyl); 2 2150.030 4.96 hyde dehydrogenase C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GALRNMLARATSSM Q8VGK3 Olfactory receptor 1 1546.803 1.98 M6(Oxidation); M14(Oxidation) Mitochondrial N-Term(Dimethyl); GALVTVGQLSCYDQAK Q9QZD8 5 1765.912 3.89 dicarboxylate carrier C11(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Mitochondrial GALVTVGQLSCYDQAK Q9QZD8 C11(Carbamidomethyl); 8 1782.002 4.55 dicarboxylate carrier K16(HeavyDimethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); GAMITHQNIINDCSGFIK D3Z041 20 2075.044 4.64 CoA ligase 1 C13(Carbamidomethyl); K18(Dimethyl)

Long-chain-fatty-acid-- N-Term(Dimethyl); M3(Oxidation); GAMITHQNIINDCSGFIK D3Z041 5 2091.033 4.59 CoA ligase 1 C13(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- GAMITHQNIINDCSGFIK D3Z041 C13(Carbamidomethyl); 14 2091.122 6.16 CoA ligase 1 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- GAMITHQNIINDCSGFIK D3Z041 M3(Oxidation); C13(Carbamidomethyl); 1 2107.119 4.45 CoA ligase 1 K18(HeavyDimethyl)

Alpha-aminoadipic N-Term(Dimethyl); GAQEVFNELPCEYVEPHELR Q99K67 semialdehyde synthase, 6 2444.145 4.11 C11(Carbamidomethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); GAQEVFNELPCEYVEPHELR Q99K67 semialdehyde synthase, 4 2452.195 4.49 C11(Carbamidomethyl) mitochondrial Sarcosine GAQVIENCAVTGIR Q99LB7 dehydrogenase, C8(Carbamidomethyl) 4 1487.760 3.01 mitochondrial Sarcosine N-Term(Dimethyl); GAQVIENCAVTGIR Q99LB7 dehydrogenase, 18 1515.792 5.60 C8(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); GAQVIENCAVTGIR Q99LB7 dehydrogenase, 17 1523.836 5.41 C8(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl); GAQVIENCAVTGIRVR Q99LB7 dehydrogenase, 2 1770.957 2.97 C8(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); GAQVIENCAVTGIRVR Q99LB7 dehydrogenase, 3 1779.002 2.94 C8(Carbamidomethyl) mitochondrial Solute carrier family 22 GASGRASLEDESGGSGRAPPEK Q497L8 N-Term(Dimethyl); K22(Dimethyl) 2 2171.087 2.42 member 16 T-complex protein 1 N-Term(Dimethyl); K4(Dimethyl); GASKEILSEVERNLQDAMQVCR E9Q133 2 2589.305 3.61 subunit gamma C21(Carbamidomethyl) GATALELMSIEVPR P70375 Coagulation factor VII M8(Oxidation) 2 1502.780 2.28 GATLVCAWAEEGADALGPDGQLLHSD N-Term(Dimethyl); P97328 Ketohexokinase 1 3346.600 3.83 AFPPPR C6(Carbamidomethyl) GATLVCAWAEEGADALGPDGQLLHSD N-Term(Dimethyl:2H(6)13C(2)); P97328 Ketohexokinase 5 3354.667 4.94 AFPPPR C6(Carbamidomethyl) Acetyl-coenzyme A N-Term(Dimethyl); GATTNICYNVLDR D6RHA7 2 1524.745 3.37 synthetase, cytoplasmic C7(Carbamidomethyl)

Acetyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); GATTNICYNVLDR D6RHA7 4 1532.790 3.18 synthetase, cytoplasmic C7(Carbamidomethyl)

Acetyl-coenzyme A N-Term(Dimethyl); GATTNICYNVLDRNVHEK D6RHA7 1 2160.082 2.45 synthetase, cytoplasmic C7(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acetyl-coenzyme A GATTNICYNVLDRNVHEK D6RHA7 C7(Carbamidomethyl); 1 2176.175 2.36 synthetase, cytoplasmic K18(HeavyDimethyl) Dihydropteridine N-Term(Dimethyl); GAVHQLCQSLAGK D3YWR7 8 1424.762 4.10 reductase C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropteridine GAVHQLCQSLAGK D3YWR7 C7(Carbamidomethyl); 7 1440.852 3.99 reductase K13(HeavyDimethyl) Alanine--glyoxylate N-Term(Dimethyl); GAYHGCSPYTLGLTNVGIYK Q3UEG6 aminotransferase 2, 1 2227.117 4.44 C6(Carbamidomethyl); K20(Dimethyl) mitochondrial Alanine--glyoxylate N-Term(Dimethyl:2H(6)13C(2)); GAYHGCSPYTLGLTNVGIYK Q3UEG6 aminotransferase 2, C6(Carbamidomethyl); 1 2243.217 2.90 mitochondrial K20(HeavyDimethyl) N-Term(Dimethyl); Heat shock 70 kDa GCALQCAILSPAFK Q61316 C2(Carbamidomethyl); 1 1591.847 2.26 protein 4 C6(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock 70 kDa C2(Carbamidomethyl); GCALQCAILSPAFK Q61316 2 1607.934 2.50 protein 4 C6(Carbamidomethyl); K14(HeavyDimethyl) Malate dehydrogenase, N-Term(Dimethyl); GCDVVVIPAGVPR P08249 7 1366.745 3.89 mitochondrial C2(Carbamidomethyl)

Malate dehydrogenase, N-Term(Dimethyl:2H(6)13C(2)); GCDVVVIPAGVPR P08249 8 1374.789 3.74 mitochondrial C2(Carbamidomethyl) N-Term(Dimethyl); Fermitin family homolog GCEVTPDVNISGQKFNIK Q8CIB5 C2(Carbamidomethyl); K14(Dimethyl); 1 2090.111 3.02 2 K18(Dimethyl) N-Term(Dimethyl); 3-ketoacyl-CoA thiolase GCFHAEIVPVTTTVLNDKGDKK Q8VCH0 C2(Carbamidomethyl); K18(Dimethyl); 4 2541.376 4.01 B, peroxisomal K21(Dimethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); 3-ketoacyl-CoA thiolase GCFHAEIVPVTTTVLNDKGDKK Q8VCH0 K18(HeavyDimethyl); 2 2573.530 3.33 B, peroxisomal K21(HeavyDimethyl); K22(HeavyDimethyl) N-Term(Dimethyl); 3-ketoacyl-CoA thiolase GCFKDTTPDELLSAVLTAVLQDVK Q8VCH0 C2(Carbamidomethyl); K4(Dimethyl); 2 2704.445 3.67 B, peroxisomal K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase C2(Carbamidomethyl); GCFKDTTPDELLSAVLTAVLQDVK Q8VCH0 3 2728.592 4.39 B, peroxisomal K4(HeavyDimethyl); K24(HeavyDimethyl) 3-hydroxyisobutyryl- N-Term(Dimethyl); GCGGVITLNRPK Q8QZS1 CoA hydrolase, 5 1327.748 2.69 C2(Carbamidomethyl); K12(Dimethyl) mitochondrial 3-hydroxyisobutyryl- N-Term(Dimethyl:2H(6)13C(2)); GCGGVITLNRPK Q8QZS1 CoA hydrolase, C2(Carbamidomethyl); 3 1343.835 2.66 mitochondrial K12(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); GCGVVKFESPEVAER Q9D0E1-2 Heterogeneous nuclear 5 1719.868 3.79 C2(Carbamidomethyl); K6(Dimethyl) ribonucleoprotein M N-Term(Dimethyl); Phosphoglycerate kinase C2(Carbamidomethyl); GCITIIGGGDTATCCAK P09411 6 1810.842 4.00 1 C14(Carbamidomethyl); C15(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); Phosphoglycerate kinase GCITIIGGGDTATCCAK P09411 C14(Carbamidomethyl); 1 1826.932 3.28 1 C15(Carbamidomethyl); K17(HeavyDimethyl) C-1-tetrahydrofolate N-Term(Dimethyl); GCLELIKEAGVQIAGR Q922D8 9 1769.991 4.90 synthase, cytoplasmic C2(Carbamidomethyl); K7(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-1-tetrahydrofolate GCLELIKEAGVQIAGR Q922D8 C2(Carbamidomethyl); 6 1786.084 4.42 synthase, cytoplasmic K7(HeavyDimethyl) Serine N-Term(Dimethyl:2H(6)13C(2)); GCLILSDELNHASLVLGAR P97363 1 2074.129 2.24 palmitoyltransferase 2 C2(Carbamidomethyl) Cadherin EGF LAG N-Term(Dimethyl:2H(6)13C(2)); GCMQGVRMGETSTNIATLNMNDALK O35161 seven-pass G-type C2(Carbamidomethyl); M20(Oxidation); 2 2800.390 3.24 receptor 1 K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GCNIKGEDDSWDFGTGAGFYVNATED S-formylglutathione C2(Carbamidomethyl); H3BJP2 1 3848.860 3.19 PWKANYR hydrolase (Fragment) K5(HeavyDimethyl); K29(HeavyDimethyl) Isoform 3 of snRNA- C2(Carbamidomethyl); M14(Oxidation); GCQGAFVPPLGSRMPYHPPSLCSLR Q8BP86-3 activating protein 1 2800.317 2.30 C22(Carbamidomethyl) complex subunit 4 N-Term(Dimethyl); GCQLLVYPGAFNLTTGPAHWELLQR Q9JHW2 Omega-amidase NIT2 1 2869.477 2.98 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GCQLLVYPGAFNLTTGPAHWELLQR Q9JHW2 Omega-amidase NIT2 2 2877.531 3.33 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GCSSSPYRFDSHTQAAMHSTVMGPILD C2(Carbamidomethyl); Q3UQD6 Protein D630036H23Rik 1 4005.159 3.67 KSEIIVFK K28(HeavyDimethyl); K35(HeavyDimethyl) N-Term(Dimethyl); GCTATLGNFAK L7N240 Protein Gm6139 6 1195.610 2.71 C2(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GCTATLGNFAK L7N240 Protein Gm6139 C2(Carbamidomethyl); 2 1211.699 2.35 K11(HeavyDimethyl) N-Term(Dimethyl); C3(Carbamidomethyl); GDCEISSVEGTLCKAAIPYDKK Q9DCG2 CD302 antigen 1 2553.263 2.42 C13(Carbamidomethyl); K14(Dimethyl); K21(Dimethyl); K22(Dimethyl) N-Term(Dimethyl); GDDILLSPCFQR P58710 L-gulonolactone oxidase 2 1448.721 2.62 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GDDILLSPCFQR P58710 L-gulonolactone oxidase 4 1456.765 2.80 C9(Carbamidomethyl) Nucleoside diphosphate N-Term(Dimethyl); GDFCIQVGR Q5NC80 8 1079.526 3.25 kinase (Fragment) C4(Carbamidomethyl) N-Term(Dimethyl); GDHYLCDVVWATEER P28843 Dipeptidyl peptidase 4 1 1877.848 2.37 C6(Carbamidomethyl) N-Term(Dimethyl); C-1-tetrahydrofolate GDLNDCFIPCTPK Q922D8 C6(Carbamidomethyl); 14 1592.740 4.00 synthase, cytoplasmic C10(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-1-tetrahydrofolate C6(Carbamidomethyl); GDLNDCFIPCTPK Q922D8 1 1608.830 4.11 synthase, cytoplasmic C10(Carbamidomethyl); K13(HeavyDimethyl) Isoform 3 of GDTPASAAGDTLSVPAPAVQHEDTIK Q8CAQ8-3 Mitochondrial inner N-Term(Dimethyl); K26(Dimethyl) 1 2604.299 2.68 membrane protein GEAGIPAEFSIWTR Q80X90 Filamin-B N-Term(Dimethyl:2H(6)13C(2)) 1 1569.861 2.04 Piezo-type GEAGKDSDESEEEEDEEEESEEEESSDL mechanosensitive ion N-Term(Dimethyl:2H(6)13C(2)); S4R1C9 1 3375.394 2.86 R channel component 2 K5(HeavyDimethyl) (Fragment) Acyl-coenzyme A N-Term(Dimethyl); GECYGLHAFVVPIR A2A848 4 1645.856 3.11 oxidase (Fragment) C3(Carbamidomethyl) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); GECYGLHAFVVPIR A2A848 2 1653.895 2.98 oxidase (Fragment) C3(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl); GEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate 5 1783.800 3.63 C8(Carbamidomethyl); K15(Dimethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); GEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate C8(Carbamidomethyl); 2 1799.890 2.36 dehydrogenase K15(HeavyDimethyl) Transcription initiation GEEAPTEGAPPEGALVEAKAPVIPEAP N-Term(Dimethyl); K19(Dimethyl); Q9D3R9 factor TFIID subunit 7- 1 3986.947 3.32 ATDVSTTEEAGSK K40(Dimethyl) like GEFPPYPKPGEVSNDPITFNTNLMGYP Epsilon-sarcoglycan F6WKE4 K8(Dimethyl) 1 4450.268 3.43 DRPGWLRYIQR (Fragment) N-Term(Dimethyl); GEGMSQAATICR P35505 Fumarylacetoacetase 5 1308.599 4.20 C11(Carbamidomethyl) N-Term(Dimethyl); M4(Oxidation); GEGMSQAATICR P35505 Fumarylacetoacetase 1 1324.592 3.08 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GEGMSQAATICR P35505 Fumarylacetoacetase 3 1332.639 3.25 M4(Oxidation); C11(Carbamidomethyl)

Isoform Short of Neural GEIDFRDIIVIVNVPPAIMMPQK O35136-2 M20(Oxidation); K23(Dimethyl) 1 2639.400 2.94 cell adhesion molecule 2 GEIDLEVPMWPTPSENDIIHLPRDMGH Cysteine-rich motor N-Term(Dimethyl:2H(6)13C(2)); Q9JLL0 1 3940.993 2.82 LQVDYR neuron 1 protein M9(Oxidation); M25(Oxidation) K3(HeavyDimethyl); GEKKPEILVDGWNIYFFDQINELPTCW Terminal K4(HeavyDimethyl); E9PUA2 1 3994.142 2.93 PEYGK uridylyltransferase 7 C26(Carbamidomethyl); K32(HeavyDimethyl) Glutaryl-CoA N-Term(Dimethyl); GELLGCFGLTEPNHGSDPGGMETR Q60759 dehydrogenase, 3 2559.164 4.65 C6(Carbamidomethyl) mitochondrial Glutaryl-CoA N-Term(Dimethyl); GELLGCFGLTEPNHGSDPGGMETR Q60759 dehydrogenase, 1 2575.157 2.43 C6(Carbamidomethyl); M21(Oxidation) mitochondrial Glutaryl-CoA N-Term(Dimethyl:2H(6)13C(2)); GELLGCFGLTEPNHGSDPGGMETR Q60759 dehydrogenase, 3 2567.217 4.02 C6(Carbamidomethyl) mitochondrial GEPGESGRPGQKGEPGFIGPQGEPGLP Collagen alpha-1(XXV) K12(HeavyDimethyl); E9Q5L6 1 3584.932 3.33 GLPGTKGDR chain K33(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas GETDEEYLWCIEQTLHFK P50247 C10(Carbamidomethyl); 1 2370.224 2.37 e K18(HeavyDimethyl) Collagen alpha-1(XXIII) GETGEMGLSGLPGADGPK Q8K4G2 K18(Dimethyl) 1 1700.801 2.22 chain Very long-chain acyl- N-Term(Dimethyl); GEVGLLVCK A2ANX6 3 1030.593 2.75 CoA synthetase C8(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Very long-chain acyl- GEVGLLVCK A2ANX6 C8(Carbamidomethyl); 7 1046.683 3.00 CoA synthetase K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Very long-chain acyl- C8(Carbamidomethyl); GEVGLLVCKITQLTPFIGYAGGK A2ANX6 1 2529.556 2.48 CoA synthetase K9(HeavyDimethyl); K23(HeavyDimethyl) Alpha-aminoadipic N-Term(Dimethyl); GEVITTYCPANNEPIAR G3UYR8 semialdehyde 17 1932.942 5.07 C8(Carbamidomethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); GEVITTYCPANNEPIAR G3UYR8 semialdehyde 11 1940.985 5.16 C8(Carbamidomethyl) dehydrogenase ATP synthase subunit O, N-Term(Dimethyl); GEVPCTVTTASPLDDAVLSELK Q9DB20 2 2358.235 2.83 mitochondrial C5(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATP synthase subunit O, GEVPCTVTTASPLDDAVLSELK Q9DB20 C5(Carbamidomethyl); 4 2374.303 3.85 mitochondrial K22(HeavyDimethyl) N-Term(Dimethyl); ATP synthase subunit O, GEVPCTVTTASPLDDAVLSELKTVLK Q9DB20 C5(Carbamidomethyl); K22(Dimethyl); 1 2827.539 2.78 mitochondrial K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GEWLAVPCQDGK P35492 Histidine ammonia-lyase C8(Carbamidomethyl); 1 1431.783 2.34 K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GEWLAVPCQDGKLTVGWLGR P35492 Histidine ammonia-lyase C8(Carbamidomethyl); 1 2314.299 2.94 K12(HeavyDimethyl) Mitochondrial N-Term(Dimethyl); GEYQGVFHCAMETAK Q9QZD8 1 1783.807 2.37 dicarboxylate carrier C9(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Mitochondrial GEYQGVFHCAMETAK Q9QZD8 C9(Carbamidomethyl); 1 1799.898 2.33 dicarboxylate carrier K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Nebulin-related- M4(Oxidation); K5(HeavyDimethyl); GFEMKLDAMSLLAAKASGELASSVK F7CXG1 anchoring protein 1 2730.633 2.28 M9(Oxidation); K15(HeavyDimethyl); (Fragment) K25(HeavyDimethyl) Heat shock protein HSP N-Term(Dimethyl); GFEVVYMTEPIDEYCVQQLK P11499 3 2504.223 3.75 90-beta C15(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP GFEVVYMTEPIDEYCVQQLK P11499 C15(Carbamidomethyl); 2 2520.304 4.50 90-beta K20(HeavyDimethyl) N-Term(Dimethyl); Heat shock protein HSP GFEVVYMTEPIDEYCVQQLKEFDGK P11499 C15(Carbamidomethyl); K20(Dimethyl); 1 3108.496 3.43 90-beta K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP C15(Carbamidomethyl); GFEVVYMTEPIDEYCVQQLKEFDGK P11499 1 3132.646 2.96 90-beta K20(HeavyDimethyl); K25(HeavyDimethyl) UDP- N-Term(Dimethyl); GFFELTFSHCR Q62452 glucuronosyltransferase 1 1428.673 2.45 C10(Carbamidomethyl) 1-9 UDP- N-Term(Dimethyl:2H(6)13C(2)); GFFELTFSHCR Q62452 glucuronosyltransferase 1 1436.719 2.43 C10(Carbamidomethyl) 1-9 Bifunctional N-Term(Dimethyl); GFFICDQPYEPVSPYSCR Q8CGC7 glutamate/proline--tRNA C5(Carbamidomethyl); 1 2249.994 2.52 ligase C17(Carbamidomethyl) Bifunctional N-Term(Dimethyl:2H(6)13C(2)); GFFICDQPYEPVSPYSCR Q8CGC7 glutamate/proline--tRNA C5(Carbamidomethyl); 1 2258.047 3.32 ligase C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein Gm16833 GFGFCSYQPHGAAHK Q3UNY1 C5(Carbamidomethyl); 1 1735.896 2.11 (Fragment) K15(HeavyDimethyl) N-Term(Dimethyl); GFGFPQGAFVTETCMSAVAAK G3X982 Aldehyde oxidase 3 6 2232.087 4.48 C14(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl); GFGFPQGAFVTETCMSAVAAK G3X982 Aldehyde oxidase 3 C14(Carbamidomethyl); 2 2248.069 3.10 M15(Oxidation); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GFGFPQGAFVTETCMSAVAAK G3X982 Aldehyde oxidase 3 C14(Carbamidomethyl); 7 2248.177 5.00 K21(HeavyDimethyl) N-Term(Dimethyl); GFGFVCFSSPEEATK D3Z5M2 Protein Gm10110 1 1718.810 2.72 C6(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GFGFVCFSSPEEATK D3Z5M2 Protein Gm10110 C6(Carbamidomethyl); 1 1734.898 2.97 K15(HeavyDimethyl) GFGFVTMTNYDEAAMAIASLNGYRLG Isoform HuC-S of N-Term(Dimethyl:2H(6)13C(2)); Q60900-2 1 3122.543 2.50 ER ELAV-like protein 3 M7(Oxidation); M15(Oxidation) N-Term(Dimethyl); GFGHIGIAVPDVYSACK Q9CPU0 Lactoylglutathione lyase 1 1846.952 2.55 C16(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GFGHIGIAVPDVYSACK Q9CPU0 Lactoylglutathione lyase C16(Carbamidomethyl); 3 1863.048 3.12 K17(HeavyDimethyl) N-Term(Dimethyl); GFGHIGIAVPDVYSACKRFEELGVK Q9CPU0 Lactoylglutathione lyase C16(Carbamidomethyl); K17(Dimethyl); 1 2833.516 3.07 K25(Dimethyl) Adenine N-Term(Dimethyl:2H(6)13C(2)); GFLFGPSLAQELGVGCVLIR P08030 phosphoribosyltransferas 3 2169.240 3.38 C16(Carbamidomethyl) e D-beta-hydroxybutyrate N-Term(Dimethyl); GFLVFAGCLMK Q80XN0 dehydrogenase, 4 1298.694 3.01 C8(Carbamidomethyl); K11(Dimethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); GFLVFAGCLMK Q80XN0 dehydrogenase, C8(Carbamidomethyl); 1 1314.792 1.97 mitochondrial K11(HeavyDimethyl) N-Term(Dimethyl); GFPCSLEHMLGQSPSPVSYVPR K9J7B2 Protein Ugt1a6b 1 2473.204 3.36 C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GFPCSLEHMLGQSPSPVSYVPR K9J7B2 Protein Ugt1a6b 2 2481.245 2.80 C4(Carbamidomethyl) K10(Dimethyl); K14(Dimethyl); Isoform 3 of Triple GFSMPGFLFKNSIKVSCLCLEENVESDP C17(Carbamidomethyl); Q0KL02-3 functional domain 1 3576.766 2.87 CK C19(Carbamidomethyl); protein C29(Carbamidomethyl); K30(Dimethyl) Bifunctional 3'- phosphoadenosine 5'- N-Term(Dimethyl); K11(Dimethyl); GFTGIDSDYEKPETPECVLK O88428 1 2369.161 3.54 phosphosulfate synthase C17(Carbamidomethyl); K20(Dimethyl) 2 Isoform 2 of N-Term(Dimethyl); GFTTCIVTNNWLDDGDKR P34914-2 Bifunctional epoxide 2 2168.044 3.32 C5(Carbamidomethyl); K17(Dimethyl) hydrolase 2 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); GFTTCIVTNNWLDDGDKR P34914-2 Bifunctional epoxide C5(Carbamidomethyl); 3 2184.136 3.47 hydrolase 2 K17(HeavyDimethyl) 4-hydroxy-2- GFVVQGSTGEFPFLTSLERLEVVSR Q9DCU9 oxoglutarate aldolase, 1 2754.469 2.17 mitochondrial GFYEEDGKDLDFYDFEPLPTLPEDEEN D3Z3X0 Protein very KIND K8(Dimethyl) 1 4590.168 3.00 VSLADILSLRDR Copper homeostasis GGAGRIELCSGLLEGGTTPSMGVLQVV C9(Carbamidomethyl); D3YY50 protein cutC homolog 1 2822.569 3.00 K K28(HeavyDimethyl) (Fragment) GGAGSAGGECDEDGAAPAGRVEEPEH Uncharacterized protein Q9CZL2 C10(Carbamidomethyl) 2 2950.271 2.53 GASPR C4orf32 homolog N-Term(Dimethyl); GGCEAIVDTGTSLLVGPVEEVKELQK F6Y6L6 Cathepsin D (Fragment) C3(Carbamidomethyl); K22(Dimethyl); 1 2812.500 3.02 K26(Dimethyl) GGDTGSGCGPGRPEGDSAPAATTRAA N-Term(Dimethyl:2H(6)13C(2)); A2A6P4 Protein Fam104a 1 3191.568 2.67 AVRAQTR C8(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl); GGDVSVCEWYR P56391 10 1355.601 3.64 subunit 6B1 C7(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl:2H(6)13C(2)); GGDVSVCEWYR P56391 10 1363.646 3.65 subunit 6B1 C7(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl); GGDVSVCEWYRR P56391 2 1511.703 2.62 subunit 6B1 C7(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl:2H(6)13C(2)); GGDVSVCEWYRR P56391 2 1519.745 2.08 subunit 6B1 C7(Carbamidomethyl) H-2 class I histocompatibility N-Term(Dimethyl); GGDYALAPGSQTSDLSLPDCK P14428 6 2208.044 4.77 antigen, K-Q alpha chain C20(Carbamidomethyl); K21(Dimethyl) (Fragment) H-2 class I N-Term(Dimethyl:2H(6)13C(2)); histocompatibility GGDYALAPGSQTSDLSLPDCK P14428 C20(Carbamidomethyl); 1 2224.145 4.81 antigen, K-Q alpha chain K21(HeavyDimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); GGETTLKCPVMLVVGDQAPHEDAVV Isoform 2 of Protein C8(Carbamidomethyl); Q9QYG0-2 1 4515.432 3.14 ECNSKLDPTQTSFLK NDRG2 C27(Carbamidomethyl); K30(HeavyDimethyl); K40(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GGFLLFGGLLLHCCACGAVMRPPPGPP Monocarboxylate C13(Carbamidomethyl); O35308 1 4268.205 3.03 PRRDPSPHGGPAR transporter 3 C14(Carbamidomethyl); C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Pyrroline-5-carboxylate GGFRAATMSAVEAATCRAK Q9DCC4 C16(Carbamidomethyl); 2 2027.125 2.76 reductase 3 K19(HeavyDimethyl) 3-ketoacyl-CoA thiolase, N-Term(Dimethyl); K3(Dimethyl); GGKYAVGSACIGGGQGIALIIQNTA Q8BWT1 1 2432.301 4.67 mitochondrial C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, GGKYAVGSACIGGGQGIALIIQNTA Q8BWT1 K3(HeavyDimethyl); 1 2448.387 3.51 mitochondrial C10(Carbamidomethyl) N-Term(Dimethyl); GGNASNSCTVLSLLGAR P97328 Ketohexokinase 7 1704.858 4.97 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GGNASNSCTVLSLLGAR P97328 Ketohexokinase 10 1712.908 5.37 C8(Carbamidomethyl) Selenium-binding N-Term(Dimethyl); GGSVQVLEDQELTCQPEPLVVK G3UYY2 16 2481.291 6.16 protein 2 C14(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Selenium-binding GGSVQVLEDQELTCQPEPLVVK G3UYY2 C14(Carbamidomethyl); 7 2497.376 6.49 protein 2 K22(HeavyDimethyl) N-Term(Dimethyl); Selenium-binding GGSVQVLEDQELTCQPEPLVVKGK G3UYY2 C14(Carbamidomethyl); K22(Dimethyl); 20 2694.434 6.47 protein 2 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Selenium-binding C14(Carbamidomethyl); GGSVQVLEDQELTCQPEPLVVKGK G3UYY2 8 2718.562 6.58 protein 2 K22(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl); Selenium-binding GGSVQVLEDQELTCQPEPLVVKGKR G3UYY2 C14(Carbamidomethyl); K22(Dimethyl); 3 2850.529 4.06 protein 2 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Selenium-binding C14(Carbamidomethyl); GGSVQVLEDQELTCQPEPLVVKGKR G3UYY2 1 2874.664 2.97 protein 2 K22(HeavyDimethyl); K24(HeavyDimethyl) Alanine--glyoxylate N-Term(Dimethyl); GGVCIADEVQTGFGR Q3UEG6 aminotransferase 2, 4 1593.766 4.54 C4(Carbamidomethyl) mitochondrial Alanine--glyoxylate N-Term(Dimethyl:2H(6)13C(2)); GGVCIADEVQTGFGR Q3UEG6 aminotransferase 2, 5 1601.811 3.39 C4(Carbamidomethyl) mitochondrial GHALGETLACLPSEVQPAPSLLSQEEW N-Term(Dimethyl); P19096 Fatty acid synthase 2 3666.801 5.14 ESLFSR C10(Carbamidomethyl) GHALGETLACLPSEVQPAPSLLSQEEW N-Term(Dimethyl:2H(6)13C(2)); P19096 Fatty acid synthase 2 3674.898 4.04 ESLFSR C10(Carbamidomethyl) Isoform 2 of FGGY carbohydrate kinase N-Term(Dimethyl); GHGLTCEGQPVTSR A2AJL3-2 2 1526.737 2.78 domain-containing C6(Carbamidomethyl) protein Isoform 2 of N-Term(Dimethyl); GHIEDCGHWTQIEKPTEVNQILIK P34914-2 Bifunctional epoxide C6(Carbamidomethyl); K14(Dimethyl); 12 2929.526 4.73 hydrolase 2 K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of C6(Carbamidomethyl); GHIEDCGHWTQIEKPTEVNQILIK P34914-2 Bifunctional epoxide 3 2953.654 4.13 K14(HeavyDimethyl); hydrolase 2 K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Non-specific lipid- GHPLGATGLAQCAELCWQLR P32020 C12(Carbamidomethyl); 1 2274.165 2.56 transfer protein C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Non-specific lipid- C12(Carbamidomethyl); GHPLGATGLAQCAELCWQLRGEAGKR P32020 1 2908.571 2.98 transfer protein C16(Carbamidomethyl); K25(HeavyDimethyl) 5-oxoprolinase N-Term(Dimethyl); GHTACADAYLTPTIQR E9Q484 1 1802.877 2.69 (Fragment) C5(Carbamidomethyl) 5-oxoprolinase N-Term(Dimethyl:2H(6)13C(2)); GHTACADAYLTPTIQR E9Q484 2 1810.920 3.55 (Fragment) C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Beta-hexosaminidase GIAAQPLYTGYCNYENKI P20060 C12(Carbamidomethyl); 1 2147.135 3.10 subunit beta K17(HeavyDimethyl) Dehydrogenase/reductas N-Term(Dimethyl); GIALQLCK Q99L04 1 958.572 2.21 e SDR family member 1 C7(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dehydrogenase/reductas GIALQLCK Q99L04 C7(Carbamidomethyl); 2 974.662 2.22 e SDR family member 1 K8(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GICFIR P40142 Transketolase 1 801.482 1.89 C3(Carbamidomethyl) N-Term(Dimethyl); GICVADPYEIR P01027 Complement C3 2 1320.663 2.42 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GICVADPYEIR P01027 Complement C3 1 1328.705 2.06 C3(Carbamidomethyl) N-Term(Dimethyl); GIDQCIPLFVEAALER Q9EPL8 Importin-7 1 1858.983 2.87 C5(Carbamidomethyl) GIEIDAQDSLGLTPLHHAARGGHVEVV F6YK91 Protein Ankrd65 N-Term(Dimethyl:2H(6)13C(2)) 1 3548.963 3.08 SHLLDR E3 SUMO-protein ligase K6(HeavyDimethyl); GIGDIKILQNYDNK Q9ERU9 2 1663.010 2.11 RanBP2 K14(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GIGLPCSTTQGK P27046 Alpha-mannosidase 2 C6(Carbamidomethyl); 2 1290.767 2.24 K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty-acid amide GIGLPVAVQCVALPWQEELCLR O08914 C10(Carbamidomethyl); 1 2544.388 2.83 hydrolase 1 C20(Carbamidomethyl) Isoform 2 of Adenylate N-Term(Dimethyl); GIHCAIDASQTPDIVFASILAAFSK Q9WTP6-2 8 2688.400 5.60 kinase 2, mitochondrial C4(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Adenylate GIHCAIDASQTPDIVFASILAAFSK Q9WTP6-2 C4(Carbamidomethyl); 9 2704.494 6.68 kinase 2, mitochondrial K25(HeavyDimethyl) Isoform 2 of Adenylate N-Term(Dimethyl); GIHCAIDASQTPDIVFASILAAFSKATS Q9WTP6-2 1 2947.529 2.82 kinase 2, mitochondrial C4(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Adenylate GIHCAIDASQTPDIVFASILAAFSKATS Q9WTP6-2 C4(Carbamidomethyl); 2 2963.623 3.56 kinase 2, mitochondrial K25(HeavyDimethyl) GIIFYHGGGAVCGSLDFYHGLGNVLA N-Term(Dimethyl); B1AVU7 Protein Gm13178 1 4347.215 3.14 HETDSVVLLVGYRK C12(Carbamidomethyl); K40(Dimethyl) Fructose-bisphosphate GILAADESVGTMGNR Q91Y97 M12(Oxidation) 6 1506.720 2.43 aldolase B N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Protein C18(Carbamidomethyl); GILAVAWSMADPELLLSCGKDAK Q3UPL0-2 1 2553.489 2.62 transport protein Sec31A K20(HeavyDimethyl); K23(HeavyDimethyl) N-Term(Dimethyl); K13(Dimethyl); GIMEEDSYPYIGKDSSCR P49935 Pro-cathepsin H 1 2162.972 3.68 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GIMEEDSYPYIGKDSSCR P49935 Pro-cathepsin H K13(HeavyDimethyl); 1 2179.058 2.71 C17(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); GIQVSNNGPCLGSR D3Z041 12 1486.736 4.18 CoA ligase 1 C10(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl:2H(6)13C(2)); GIQVSNNGPCLGSR D3Z041 2 1494.787 4.07 CoA ligase 1 C10(Carbamidomethyl) N-Term(Dimethyl); GIRNIETFAMNICEHFLSSFNHVTR P25688 Uricase 1 3021.502 2.91 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isobutyryl-CoA C4(Carbamidomethyl); GISCIVVEKGTPGLSFGKK Q9D7B6 dehydrogenase, K9(HeavyDimethyl); 2 2121.384 2.89 mitochondrial K18(HeavyDimethyl); K19(HeavyDimethyl) Inorganic N-Term(Dimethyl); GISCMNTTVSESPFK Q9D819 2 1713.814 2.83 pyrophosphatase C4(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Inorganic GISCMNTTVSESPFK Q9D819 C4(Carbamidomethyl); 1 1729.904 2.13 pyrophosphatase K15(HeavyDimethyl)

N-Term(Dimethyl); Inorganic GISCMNTTVSESPFKCDPDAAK Q9D819 C4(Carbamidomethyl); K15(Dimethyl); 7 2499.155 3.50 pyrophosphatase C16(Carbamidomethyl); K22(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); Inorganic GISCMNTTVSESPFKCDPDAAK Q9D819 K15(HeavyDimethyl); 3 2523.279 2.91 pyrophosphatase C16(Carbamidomethyl); K22(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); GIVPLAKVDCTANTNTCNKYGVSGYP C10(Carbamidomethyl); F6Q404 Thioredoxin (Fragment) 1 3253.669 3.40 TLK C17(Carbamidomethyl); K19(Dimethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); GIVPLAKVDCTANTNTCNKYGVSGYP Protein disulfide- C10(Carbamidomethyl); P27773 3 3285.873 5.43 TLK isomerase A3 C17(Carbamidomethyl); K19(HeavyDimethyl); K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, K2(HeavyDimethyl); GKCTTDHISAAGPWLK Q99KI0 1 1850.096 2.31 mitochondrial C3(Carbamidomethyl); K16(HeavyDimethyl) Proteasome subunit N-Term(Dimethyl); K2(Dimethyl); GKDCAVIVTQK E0CXB1 9 1302.741 3.45 alpha type-6 C4(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit K2(HeavyDimethyl); GKDCAVIVTQK E0CXB1 4 1326.874 3.62 alpha type-6 C4(Carbamidomethyl); K11(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); GKEAPFTHFDPSCLFPACR P16015 Carbonic anhydrase 3 C13(Carbamidomethyl); 5 2293.085 3.37 C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); GKEAPFTHFDPSCLFPACR P16015 Carbonic anhydrase 3 2 2309.175 3.19 C13(Carbamidomethyl); C18(Carbamidomethyl) Mitochondrial import GKEDPWNSISSGALTGAVLAARSGPLA inner membrane N-Term(Dimethyl:2H(6)13C(2)); A2AES1 1 3874.125 2.65 MVGSAMMGGILL translocase subunit K2(HeavyDimethyl); M33(Oxidation) Tim17-B (Fragment) N-Term(Dimethyl); K2(Dimethyl); GKFPDVPGFSWVTPCISAK Q61176 Arginase-1 15 2177.145 4.70 C15(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); GKFPDVPGFSWVTPCISAK Q61176 Arginase-1 16 2201.281 4.86 C15(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GKLPPGPTPLPIIGNILQIDVKDICQSFT K2(HeavyDimethyl); Q6XVG2 Cytochrome P450 2C54 1 3710.224 2.97 NLSR K22(HeavyDimethyl); C25(Carbamidomethyl) Low-density lipoprotein K2(HeavyDimethyl); GKLYWSDHGTDSGVPAKIASANMDG A2ARV4 receptor-related protein K17(HeavyDimethyl); 1 3114.668 2.83 TSLK 2 K29(HeavyDimethyl) Proteasome subunit beta N-Term(Dimethyl); K2(Dimethyl); GKNCVAIAADRR Q9R1P1 4 1386.761 4.15 type-3 C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit beta GKNCVAIAADRR Q9R1P1 K2(HeavyDimethyl); 3 1402.849 3.62 type-3 C4(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); GKNMCGLAACASYPIPQV P49935 Pro-cathepsin H C5(Carbamidomethyl); 1 1992.967 2.41 C10(Carbamidomethyl) 116 kDa U5 small nuclear GLAALDSSRDLVTGPSSSEHR G3UZ25 2 2155.090 2.44 ribonucleoprotein component (Fragment) Membrane-associated N-Term(Dimethyl:2H(6)13C(2)); GLATFCLDK Q80UU9 progesterone receptor C6(Carbamidomethyl); 1 1096.661 1.99 component 2 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Membrane-associated C6(Carbamidomethyl); GLATFCLDKEALKDEYDDLSDLTPAQ O55022 progesterone receptor K9(HeavyDimethyl); 1 4785.484 3.29 QETLSDWDSQFTFK component 1 K13(HeavyDimethyl); K40(HeavyDimethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); GLAVSDNGPCLGYR Q8JZR0 4 1506.733 3.18 CoA ligase 5 C10(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl:2H(6)13C(2)); GLAVSDNGPCLGYR Q8JZR0 9 1514.780 4.43 CoA ligase 5 C10(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); GLCAIAQAESLR D3YV43 12 1316.697 3.50 S3 C3(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); GLCAIAQAESLR D3YV43 5 1324.742 3.62 S3 C3(Carbamidomethyl) ATP synthase subunit N-Term(Dimethyl); GLCGAIHSSVAK A2AKV0 gamma, mitochondrial 2 1255.682 3.38 C3(Carbamidomethyl); K12(Dimethyl) (Fragment) ATP synthase subunit N-Term(Dimethyl:2H(6)13C(2)); GLCGAIHSSVAK A2AKV0 gamma, mitochondrial C3(Carbamidomethyl); 7 1271.767 3.45 (Fragment) K12(HeavyDimethyl) Bifunctional ATP- dependent N-Term(Dimethyl); GLCGTVLIHK Q8VC30 dihydroxyacetone 1 1153.671 2.27 C3(Carbamidomethyl); K10(Dimethyl) kinase/FAD-AMP lyase (cyclizing) Bifunctional ATP- dependent N-Term(Dimethyl:2H(6)13C(2)); GLCGTVLIHK Q8VC30 dihydroxyacetone C3(Carbamidomethyl); 1 1169.766 2.34 kinase/FAD-AMP lyase K10(HeavyDimethyl) (cyclizing) Bifunctional ATP- dependent N-Term(Dimethyl); GLCGTVLIHKVAGALAEEGMGLEEITK Q8VC30 dihydroxyacetone C3(Carbamidomethyl); K10(Dimethyl); 1 3036.680 2.85 R kinase/FAD-AMP lyase K27(Dimethyl) (cyclizing) Membrane-associated N-Term(Dimethyl); GLCSGPGAGEESPAATLPR Q80UU9 progesterone receptor 4 1854.895 3.73 C3(Carbamidomethyl) component 2 Membrane-associated N-Term(Dimethyl:2H(6)13C(2)); GLCSGPGAGEESPAATLPR Q80UU9 progesterone receptor 2 1862.934 3.19 C3(Carbamidomethyl) component 2 Serine N-Term(Dimethyl); GLELIASENFCSR Q9CZN7 hydroxymethyltransferas 1 1523.755 2.56 C11(Carbamidomethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); GLELIASENFCSR Q9CZN7 hydroxymethyltransferas 5 1531.802 2.60 C11(Carbamidomethyl) e N-Term(Dimethyl:2H(6)13C(2)); GLEVSKCEIAR Q9WUM3 Coronin-1B K6(HeavyDimethyl); 1 1333.808 2.32 C7(Carbamidomethyl) Isoform 4 of NACHT, GLFSSLSTNRSLTELDLSDNTLGDPGM Q8R4B8-4 LRR and PYD domains- M27(Oxidation) 1 3012.491 2.65 R containing protein 3 N-Term(Dimethyl); GLGDCLVK P51881 ADP/ATP translocase 2 1 917.509 2.35 C5(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GLGDCLVK P51881 ADP/ATP translocase 2 C5(Carbamidomethyl); 3 933.596 2.21 K8(HeavyDimethyl) N-Term(Dimethyl); GLGHEADESADVGTVETTMCK Q61635 GTP-binding protein 2 2263.021 3.35 C20(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl); GLGTDEDSLIEIICSR B0V2N8 Annexin (Fragment) 1 1805.883 2.49 C14(Carbamidomethyl) GLGTSTAHAASQSQAQDVRVEGAFPV Isocitrate dehydrogenase Q91VA7 M39(Oxidation); K43(HeavyDimethyl) 1 4369.183 2.90 TMLPGDGVGPELMHAVK 3 (NAD+) beta K3(HeavyDimethyl); GLKYIHSAGIIHRDLKPSNVAVNEDCE Mitogen-activated Q9WUI1 K16(HeavyDimethyl); 1 3376.872 2.91 LR protein kinase 11 C26(Carbamidomethyl) GLLDAAHFCYLMAQVGFGVYTKKTT Protein Sec16a C9(Carbamidomethyl); K22(Dimethyl); F7BPW6 1 3003.543 2.83 K (Fragment) K23(Dimethyl); K26(Dimethyl) 26S proteasome non- N-Term(Dimethyl:2H(6)13C(2)); GLLGCNIIPLQR Q9CR00 ATPase regulatory 2 1389.848 2.55 C5(Carbamidomethyl) subunit 9 Isoform 2 of 2- N-Term(Dimethyl); oxoisovalerate GLLLSCIEDKNPCIFFEPK Q6P3A8-2 C6(Carbamidomethyl); K10(Dimethyl); 1 2364.235 2.64 dehydrogenase subunit C13(Carbamidomethyl); K19(Dimethyl) beta, mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of 2- C6(Carbamidomethyl); oxoisovalerate GLLLSCIEDKNPCIFFEPK Q6P3A8-2 K10(HeavyDimethyl); 2 2388.358 3.23 dehydrogenase subunit C13(Carbamidomethyl); beta, mitochondrial K19(HeavyDimethyl) Carbamoyl-phosphate GLNSDSVTEETLR Q8C196 synthase [ammonia], 2 1420.691 2.52 mitochondrial Carbamoyl-phosphate GLNSDSVTEETLR Q8C196 synthase [ammonia], N-Term(Dimethyl) 2 1448.723 3.12 mitochondrial Receptor expression- GLNVAATAAVMAASKGQGALSERLR Q8BGH4 M11(Oxidation); K15(Dimethyl) 1 2486.336 2.38 enhancing protein 1 Isoform 2 of N- N-Term(Dimethyl:2H(6)13C(2)); GLPDSFCKPASDPGS Q8R4H7-2 acetylglutamate C7(Carbamidomethyl); 1 1606.830 2.57 synthase, mitochondrial K8(HeavyDimethyl) GLPFAQWDGPTVVAWLELWLGMPA C30(Carbamidomethyl); B8QI34 Liprin-alpha 2 1 4009.038 2.71 WYVAACRANVK K35(HeavyDimethyl) Dihydropyrimidine N-Term(Dimethyl); K7(Dimethyl); GLPLAVKPVC Q8CHR6 dehydrogenase 2 1109.674 2.21 C10(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); GLPLAVKPVC Q8CHR6 dehydrogenase K7(HeavyDimethyl); 1 1125.762 2.10 [NADP(+)] C10(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); GLQGSFEELCR D3Z041 13 1323.635 4.04 CoA ligase 1 C10(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl:2H(6)13C(2)); GLQGSFEELCR D3Z041 14 1331.680 3.56 CoA ligase 1 C10(Carbamidomethyl) Glycerol-3-phosphate N-Term(Dimethyl:2H(6)13C(2)); GLSGLRGRDFELSDVFYFSK Q8C0N2 1 2365.317 2.25 acyltransferase 3 K20(HeavyDimethyl) GLSICTSSLLTVVQAITMSPR Q8R265 Protein Vmn1r197 C5(Carbamidomethyl) 1 2234.173 2.45 Isoform 2 of Acylamino- N-Term(Dimethyl); GLSRQPSLSAACLGPEVTTQYGGLYR Q8R146-2 4 2809.441 4.33 acid-releasing enzyme C12(Carbamidomethyl)

Isoform 2 of Acylamino- N-Term(Dimethyl:2H(6)13C(2)); GLSRQPSLSAACLGPEVTTQYGGLYR Q8R146-2 4 2817.481 3.78 acid-releasing enzyme C12(Carbamidomethyl) C10(Carbamidomethyl); C15(Carbamidomethyl); GLSSLIYFHCSALICNQVSLDSPLCSVT Zona pellucida sperm- P20239 C25(Carbamidomethyl); 1 4077.001 3.04 CPASLRSK binding protein 2 C29(Carbamidomethyl); K36(HeavyDimethyl) GLSTKTKTALNLGLNGTVGPR B7ZCC4 Protein Atxn7l2 K5(Dimethyl); K7(Dimethyl) 1 2154.284 2.78 Mitochondrial N-Term(Dimethyl); GLSVSEAECTAMGLR Q9CW42 amidoxime-reducing 4 1608.762 2.93 C9(Carbamidomethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GLSVSEAECTAMGLR Q9CW42 amidoxime-reducing 1 1616.812 2.15 C9(Carbamidomethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GLSVSEAECTAMGLR Q9CW42 amidoxime-reducing 1 1632.803 2.49 C9(Carbamidomethyl); M12(Oxidation) component 1 GLTDNFADVQVSVVDCPDLTKEPFTFP Ester hydrolase N-Term(Dimethyl); Q91V76 1 3322.690 3.32 VR C11orf54 homolog C16(Carbamidomethyl); K21(Dimethyl) Arf-GAP with GTPase, N-Term(Dimethyl); GLTPLAYARRAGSQECADILIQHGCPG ANK repeat and PH C16(Carbamidomethyl); F8VQE9 1 4091.954 2.86 EGCGLAPTPNR domain-containing C25(Carbamidomethyl); protein 3 C30(Carbamidomethyl) N-Term(Dimethyl); GLVVLGFPCNQFGHQENGKNEEILNSL P11352 Glutathione peroxidase 1 C9(Carbamidomethyl); K19(Dimethyl); 5 3225.682 4.26 K K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GLVVLGFPCNQFGHQENGKNEEILNSL C9(Carbamidomethyl); P11352 Glutathione peroxidase 1 3 3249.813 5.14 K K19(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl); GLYAAFDCTATMK G5E8R3 Pyruvate carboxylase 1 1504.710 2.43 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GLYAAFDCTATMK G5E8R3 Pyruvate carboxylase C8(Carbamidomethyl); 1 1520.808 2.07 K13(HeavyDimethyl) Dihydropyrimidinase- N-Term(Dimethyl); GLYDGPVCEVSVTPK O08553 4 1676.855 3.85 related protein 2 C8(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropyrimidinase- GLYDGPVCEVSVTPK O08553 C8(Carbamidomethyl); 6 1692.940 3.59 related protein 2 K15(HeavyDimethyl) L-lactate dehydrogenase N-Term(Dimethyl); GLYGINEDVFLSVPCILGQNGISDVVK P06151 3 2962.568 5.04 A chain C15(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); L-lactate dehydrogenase GLYGINEDVFLSVPCILGQNGISDVVK P06151 C15(Carbamidomethyl); 3 2978.664 3.64 A chain K27(HeavyDimethyl) Isoform 5 of Trafficking GMEASEFLQNAVYINLR Q3U0M1-5 protein particle complex M2(Oxidation) 1 1970.984 2.29 subunit 9 Dihydropyrimidine N-Term(Dimethyl); GMGLACGQDPELVR Q8CHR6 dehydrogenase 4 1530.740 3.62 C6(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); GMGLACGQDPELVR Q8CHR6 dehydrogenase 5 1538.788 4.16 C6(Carbamidomethyl) [NADP(+)] C15(Carbamidomethyl); GMLASGAPNLVIPICTLIQLVLCGIWLV L7N2A0 Protein Vmn2r15 C23(Carbamidomethyl); 1 4865.690 2.80 TSPPFIDRDIQSEHGK K44(HeavyDimethyl) N-Term(Dimethyl); M2(Oxidation); Interferon-activable GMSEEKTDVKK Q8CGE8 K6(Dimethyl); K10(Dimethyl); 1 1379.738 2.64 protein 205-A K11(Dimethyl) Isoform 2 of 4- N-Term(Dimethyl); aminobutyrate GMSQLITMACGSCSNENAFK P61922-2 C10(Carbamidomethyl); 3 2262.005 4.51 aminotransferase, C13(Carbamidomethyl); K20(Dimethyl) mitochondrial Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate C10(Carbamidomethyl); GMSQLITMACGSCSNENAFK P61922-2 2 2278.098 3.82 aminotransferase, C13(Carbamidomethyl); mitochondrial K20(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl); K4(Dimethyl); GNDKVPGAWTEACGQK Q8R0Y6 formyltetrahydrofolate 5 1801.887 2.92 C13(Carbamidomethyl); K16(Dimethyl) dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); Cytosolic 10- K4(HeavyDimethyl); GNDKVPGAWTEACGQK Q8R0Y6 formyltetrahydrofolate 3 1826.019 3.01 C13(Carbamidomethyl); dehydrogenase K16(HeavyDimethyl) N-Term(Dimethyl); GNDQVRFELTCYSLAPQIK J3QNG0 MCG15755 14 2295.181 5.55 C11(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GNDQVRFELTCYSLAPQIK J3QNG0 MCG15755 C11(Carbamidomethyl); 24 2311.268 5.98 K19(HeavyDimethyl) Carbamoyl-phosphate GNDVLVIECNLR Q8C196 synthase [ammonia], C9(Carbamidomethyl) 3 1401.720 3.05 mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); GNDVLVIECNLR Q8C196 synthase [ammonia], 19 1429.749 4.05 C9(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); GNDVLVIECNLR Q8C196 synthase [ammonia], 19 1437.788 4.17 C9(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); GNDVLVIECNLRASR Q8C196 synthase [ammonia], 1 1751.963 2.33 C9(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GNEEPDPPVRLFQIHGNDKSNTK O88398 Advillin K19(HeavyDimethyl); 1 2700.522 2.66 K23(HeavyDimethyl) Glutamine--fructose-6- phosphate GNFSAFMQKEIFEQPESVFNTMR Q9Z2Z9 K9(Dimethyl) 1 2765.303 2.39 aminotransferase [isomerizing] 2 GNKGFIVFNNDDWALSETLQTGLPAG N-Term(Dimethyl); K3(Dimethyl); P00687 Alpha-amylase 1 1 3986.944 3.04 TYCDVISGDK C29(Carbamidomethyl); K36(Dimethyl) N-acetylated-alpha- GNKVKNAMLAGAMGIILYSDPADYFA K3(Dimethyl); K5(Dimethyl); Q9CZR2 linked acidic dipeptidase 1 3754.950 3.37 PDVQPYPK M13(Oxidation); K34(Dimethyl) 2 Carbamoyl-phosphate N-Term(Dimethyl); K5(Dimethyl); GNPTKVVAVDCGIK Q8C196 synthase [ammonia], 7 1541.867 4.53 C11(Carbamidomethyl); K14(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K5(HeavyDimethyl); GNPTKVVAVDCGIK Q8C196 synthase [ammonia], 8 1565.997 4.74 C11(Carbamidomethyl); mitochondrial K14(HeavyDimethyl) Carbamoyl-phosphate K5(Dimethyl); C11(Carbamidomethyl); GNPTKVVAVDCGIKNNVIR Q8C196 synthase [ammonia], 1 2110.176 3.21 K14(Dimethyl) mitochondrial Carbamoyl-phosphate K5(HeavyDimethyl); GNPTKVVAVDCGIKNNVIR Q8C196 synthase [ammonia], C11(Carbamidomethyl); 1 2126.267 2.39 mitochondrial K14(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); K5(Dimethyl); GNPTKVVAVDCGIKNNVIR Q8C196 synthase [ammonia], 16 2138.202 5.56 C11(Carbamidomethyl); K14(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K5(HeavyDimethyl); GNPTKVVAVDCGIKNNVIR Q8C196 synthase [ammonia], 14 2162.339 5.99 C11(Carbamidomethyl); mitochondrial K14(HeavyDimethyl) Betaine--homocysteine S-K7(Dimethyl); K12(Dimethyl); GNYVAEKISGQKVNEAACDIAR O35490 1 2449.234 2.80 methyltransferase 1 C18(Carbamidomethyl) K7(HeavyDimethyl); Betaine--homocysteine S- GNYVAEKISGQKVNEAACDIAR O35490 K12(HeavyDimethyl); 4 2465.335 2.64 methyltransferase 1 C18(Carbamidomethyl) Betaine--homocysteine S-N-Term(Dimethyl); K7(Dimethyl); GNYVAEKISGQKVNEAACDIAR O35490 32 2477.274 6.28 methyltransferase 1 K12(Dimethyl); C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-K7(HeavyDimethyl); GNYVAEKISGQKVNEAACDIAR O35490 24 2501.404 6.60 methyltransferase 1 K12(HeavyDimethyl); C18(Carbamidomethyl) GPAPREDIESGAEAAEGEGDIFPSSHYL N-Term(Dimethyl:2H(6)13C(2)); E9Q5R9 Protein Wiz (Fragment) 1 3851.937 2.58 PITKEGPR K32(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); GPCIIYNEDNGIIK Q9D8E6 1 1661.854 2.39 L4 C3(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein GPCIIYNEDNGIIK Q9D8E6 C3(Carbamidomethyl); 3 1677.940 3.22 L4 K14(HeavyDimethyl) Isoform 2 of Rho GPDIKVQFQALHLMVMALPDANRDTA K5(HeavyDimethyl); M16(Oxidation); Q8BN58-2 GTPase-activating 1 4006.117 3.21 QALMAFFNK M30(Oxidation); K35(HeavyDimethyl) protein 28 Probable ATP- K6(HeavyDimethyl); M9(Oxidation); GPENPKLEMLERILLK Q99J87 dependent RNA helicase 1 1968.186 2.21 K16(HeavyDimethyl) DHX58 K11(HeavyDimethyl); M19(Oxidation); GPGIGLLGISKGGELGLAMASFLKGITA Acyl-coenzyme A O55137 K24(HeavyDimethyl); 1 4496.672 2.60 AVVINGSVAAVGNTISYK thioesterase 1 K46(HeavyDimethyl) M5(Oxidation); K6(HeavyDimethyl); GPMSMKEVDEQMLAIQNKNSSYFVE Q922F4 Tubulin beta-6 chain K18(HeavyDimethyl); 1 3850.966 3.47 WIPNNVK K32(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); M9(Oxidation); GPPGLEKPMSMLSVLRAYSADGLAAF Zinc finger protein 536 Q3TR09 M11(Oxidation); 1 4179.240 2.98 NGLASSTANSGCIK (Fragment) C38(Carbamidomethyl); K40(HeavyDimethyl) Isoform 3 of General transcription factor II-I GPSEEPWSEERPAEESPGDVIRPLRK Q9JI57-3 N-Term(Dimethyl); K26(Dimethyl) 1 3003.481 2.60 repeat domain- containing protein 1 Cytosolic 10- GQALPEVVAKYQALGAELNVLPFCSQ N-Term(Dimethyl); K10(Dimethyl); Q8R0Y6 formyltetrahydrofolate 2 4126.177 5.58 FIPMEVINAPR C24(Carbamidomethyl) dehydrogenase Cytosolic 10- GQALPEVVAKYQALGAELNVLPFCSQ N-Term(Dimethyl); K10(Dimethyl); Q8R0Y6 formyltetrahydrofolate 1 4142.203 2.90 FIPMEVINAPR C24(Carbamidomethyl); M30(Oxidation) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); GQALPEVVAKYQALGAELNVLPFCSQ Q8R0Y6 formyltetrahydrofolate K10(HeavyDimethyl); 7 4142.296 7.46 FIPMEVINAPR dehydrogenase C24(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); GQALPEVVAKYQALGAELNVLPFCSQ Q8R0Y6 formyltetrahydrofolate K10(HeavyDimethyl); 4 4158.283 4.22 FIPMEVINAPR dehydrogenase C24(Carbamidomethyl); M30(Oxidation)

GQAPDTLSYLDSVSLMSGTLESLPDDV TBC1 domain family M39(Oxidation); K43(HeavyDimethyl); Q8BHL3 1 4906.410 3.13 SSMGSDSEINGMALRKTDK member 10B K46(HeavyDimethyl) DNA replication N-Term(Dimethyl:2H(6)13C(2)); GQASQITASSLVQNYK Q9CY94 complex GINS protein 1 1767.019 2.38 K16(HeavyDimethyl) PSF3 N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); GQCDLELINVCNENSLFK Q68FD5 Clathrin heavy chain 1 1 2225.158 3.62 C11(Carbamidomethyl); K18(HeavyDimethyl) Methionine N-Term(Dimethyl:2H(6)13C(2)); GQECEYPPTQDGR M0QW48 aminopeptidase 2 1 1572.705 2.22 C4(Carbamidomethyl) (Fragment) C16(Carbamidomethyl); C19(Carbamidomethyl); K22(HeavyDimethyl); GQGPPGSGQSQQHIECVVCGDKSSGK COUP transcription Q32NY6 K26(HeavyDimethyl); 1 4160.008 2.82 HYGQFTCEGCK factor 1 C33(Carbamidomethyl); C36(Carbamidomethyl); K37(HeavyDimethyl) N-Term(Dimethyl); Protein disulfide- GQGTVCWVDCGDAESR Q921X9 C6(Carbamidomethyl); 1 1824.754 3.35 isomerase A5 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein disulfide- GQGTVCWVDCGDAESR Q921X9 C6(Carbamidomethyl); 3 1832.799 3.90 isomerase A5 C10(Carbamidomethyl) Carbamoyl-phosphate GQILTMANPIIGNGGAPDTTAR Q8C196 synthase [ammonia], N-Term(Dimethyl); M6(Oxidation) 1 2212.164 2.80 mitochondrial Ectonucleoside GQKDCAFNGIYQPPVHGQFYAFSNFY N-Term(Dimethyl); K3(Dimethyl); Q8K0L2 triphosphate 1 4491.153 3.39 YTFHFLNLTSR C5(Carbamidomethyl) diphosphohydrolase 8 Delta-1-pyrroline-5- N-Term(Dimethyl:2H(6)13C(2)); GQMEAIPCVVGDEEVWTSDIQYQLSPF carboxylate Q8CHT0 C8(Carbamidomethyl); 1 3757.857 3.18 NHAHK dehydrogenase, K32(HeavyDimethyl) mitochondrial Low molecular weight N-Term(Dimethyl:2H(6)13C(2)); GQNCMRKHGIHMQHIAR Q9D358 phosphotyrosine protein C4(Carbamidomethyl); M5(Oxidation); 1 2162.141 2.74 phosphatase K7(HeavyDimethyl) N-Term(Dimethyl); Homogentisate 1,2- GQNNPQVCPYNLYAEQLSGSAFTCPR O09173 C8(Carbamidomethyl); 3 2999.380 6.26 dioxygenase C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- GQNNPQVCPYNLYAEQLSGSAFTCPR O09173 C8(Carbamidomethyl); 8 3007.429 6.69 dioxygenase C24(Carbamidomethyl) N-Term(Dimethyl); GQYCYELDETAVRPGYPK P29788 Vitronectin 1 2202.058 4.25 C4(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GQYCYELDETAVRPGYPK P29788 Vitronectin C4(Carbamidomethyl); 1 2218.144 2.84 K18(HeavyDimethyl) Mitochondrial N-Term(Dimethyl); GRDCGDEVAQWFTNYLK Q922Q1 amidoxime reducing 4 2114.997 3.25 C4(Carbamidomethyl); K17(Dimethyl) component 2 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GRDCGDEVAQWFTNYLK Q922Q1 amidoxime reducing C4(Carbamidomethyl); 1 2131.074 3.12 component 2 K17(HeavyDimethyl) Isoform 2 of 4- aminobutyrate N-Term(Dimethyl); GRGTFCSFDTPDEAIR P61922-2 3 1856.856 2.68 aminotransferase, C6(Carbamidomethyl) mitochondrial Isoform 2 of 4- aminobutyrate N-Term(Dimethyl:2H(6)13C(2)); GRGTFCSFDTPDEAIR P61922-2 4 1864.895 2.52 aminotransferase, C6(Carbamidomethyl) mitochondrial GRPDLYSFTLITNGKSMTFNPDSGPVW N-Term(Dimethyl:2H(6)13C(2)); P00186 Cytochrome P450 1A2 1 3386.786 3.21 AAR K15(HeavyDimethyl); M17(Oxidation) EP300-interacting GRPMAAAREGPAAPAAAARGGR Q6X7S9 inhibitor of N-Term(Dimethyl) 1 2090.086 2.75 differentiation 2 GRSGETGPVGPPGSPGPPGPPGPPGPGI Isoform 3 of Collagen P28481-2 N-Term(Dimethyl); K41(Dimethyl) 1 3875.901 2.95 DMSAFAGLGQREK alpha-1(II) chain N-Term(Dimethyl); ATP-dependent RNA GSAFAIGSDGLCCQSR Q91VR5 C12(Carbamidomethyl); 2 1713.764 2.47 helicase DDX1 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ATP-dependent RNA GSAFAIGSDGLCCQSR Q91VR5 C12(Carbamidomethyl); 2 1721.809 3.40 helicase DDX1 C13(Carbamidomethyl) GSAGGK O08784 Treacle protein N-Term(Dimethyl); K6(Dimethyl) 1 532.303 0.53 60S ribosomal protein N-Term(Dimethyl); K10(Dimethyl); GSAITGPVAKECADLWPR P62830 1 1984.040 2.65 L23 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein GSAITGPVAKECADLWPR P62830 K10(HeavyDimethyl); 1 2000.128 3.30 L23 C12(Carbamidomethyl) Isoform 2 of PHD finger GSALDAAVSPLCENGDDSLSPR Q8BLG0-2 C12(Carbamidomethyl) 1 2231.009 2.34 protein 20 Alpha-aminoadipic N-Term(Dimethyl); GSDCGIVNVNIPTSGAEIGGAFGGEK G3UYR8 semialdehyde 7 2562.255 5.12 C4(Carbamidomethyl); K26(Dimethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); GSDCGIVNVNIPTSGAEIGGAFGGEK G3UYR8 semialdehyde C4(Carbamidomethyl); 1 2578.342 3.31 dehydrogenase K26(HeavyDimethyl) Alpha-aminoadipic GSDCGIVNVNIPTSGAEIGGAFGGEKH N-Term(Dimethyl); G3UYR8 semialdehyde 1 3127.531 3.38 TGGGR C4(Carbamidomethyl); K26(Dimethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); GSDCGIVNVNIPTSGAEIGGAFGGEKH G3UYR8 semialdehyde C4(Carbamidomethyl); 3 3143.601 3.05 TGGGR dehydrogenase K26(HeavyDimethyl) N-Term(Dimethyl); Long-chain-fatty-acid-- GSFEELCKNQCVK Q8JZR0 C7(Carbamidomethyl); K8(Dimethyl); 2 1682.822 2.57 CoA ligase 5 C11(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); Long-chain-fatty-acid-- GSFEELCKNQCVK Q8JZR0 K8(HeavyDimethyl); 1 1706.947 3.40 CoA ligase 5 C11(Carbamidomethyl); K13(HeavyDimethyl) GSGEPPPPPPLEPPAACMGLSTQSSLPS Isoform 2 of Retinoic C17(Carbamidomethyl); Q61818-2 1 3349.720 3.28 AVRTK acid-induced protein 1 K33(HeavyDimethyl) Isoform 3 of DnaJ N-Term(Dimethyl); homolog subfamily A GSIITNPCVVCR Q99M87-3 C8(Carbamidomethyl); 2 1403.711 2.32 member 3, C11(Carbamidomethyl) mitochondrial Isoform 3 of DnaJ N-Term(Dimethyl:2H(6)13C(2)); homolog subfamily A GSIITNPCVVCR Q99M87-3 C8(Carbamidomethyl); 1 1411.762 2.15 member 3, C11(Carbamidomethyl) mitochondrial Isoform 3 of Dynein N-Term(Dimethyl); M11(Oxidation); GSILYFLITEMSMVNIMYQTSLAQFLK Q91XQ0-3 1 3213.702 2.86 heavy chain 8, axonemal K27(Dimethyl) N-Term(Dimethyl); Isovaleryl-CoA C5(Carbamidomethyl); GSNTCELVFEDCKVPAANVLSQESK Q9JHI5 dehydrogenase, 8 2866.398 4.15 C12(Carbamidomethyl); K13(Dimethyl); mitochondrial K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isovaleryl-CoA C5(Carbamidomethyl); GSNTCELVFEDCKVPAANVLSQESK Q9JHI5 dehydrogenase, C12(Carbamidomethyl); 5 2890.518 5.01 mitochondrial K13(HeavyDimethyl); K25(HeavyDimethyl) Collagen alpha-2(I) GSPGEAGSAGPAGPPGLR Q01149 N-Term(Dimethyl) 2 1562.802 2.46 chain Bifunctional N-Term(Dimethyl:2H(6)13C(2)); GSQFGQSCCLR Q8CGC7 glutamate/proline--tRNA C8(Carbamidomethyl); 2 1335.627 2.13 ligase C9(Carbamidomethyl) GSRGTRGSQMDSHSSGSNYHDSWETR E9Q784 Protein Zc3h13 N-Term(Dimethyl:2H(6)13C(2)) 1 2918.312 2.90 Ubiquitin-conjugating GSSDGDQRESVQQEPDREQVQPK H3BL23 enzyme E2 E2 K23(Dimethyl) 1 2627.212 2.88 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); GSSHQVENEILFPGCVLR Q8R0F9 SEC14-like protein 4 2 2078.094 3.15 C15(Carbamidomethyl) N-Term(Dimethyl); GSSHQVEYEILFPGCVLR Q99J08 SEC14-like protein 2 2 2119.055 2.92 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GSSHQVEYEILFPGCVLR Q99J08 SEC14-like protein 2 3 2127.109 3.76 C15(Carbamidomethyl) Isoform Soluble of N-Term(Dimethyl:2H(6)13C(2)); GSSSFECTHYSSYLEYMK O88587-2 Catechol O- C7(Carbamidomethyl); 2 2248.049 3.75 methyltransferase K18(HeavyDimethyl) Inactive serine/threonine- N-Term(Dimethyl:2H(6)13C(2)); GSTFCWNGQEAMRTLSAKFTTVR Q5ND21 protein kinase TEX14 C5(Carbamidomethyl); 1 2720.405 2.68 (Fragment) K18(HeavyDimethyl)

N-Term(Dimethyl); K9(Dimethyl); GSVLPNSDKKADCTITMADSDLLALM Non-specific lipid- P32020 K10(Dimethyl); C13(Carbamidomethyl); 2 3164.651 3.77 TGK transfer protein K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K9(HeavyDimethyl); GSVLPNSDKKADCTITMADSDLLALM Non-specific lipid- P32020 K10(HeavyDimethyl); 2 3196.809 4.31 TGK transfer protein C13(Carbamidomethyl); K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); Low-density lipoprotein C5(Carbamidomethyl); GSYKCVCDQNFQEKNNSCIAK F6YDG9 receptor-related protein C7(Carbamidomethyl); 1 2694.434 2.61 1B (Fragment) K14(HeavyDimethyl); C18(Carbamidomethyl); K21(HeavyDimethyl) K16(HeavyDimethyl); Regulator of G-protein GSYNPSHMQMSSDFYKCEIECFR Q9Z2H1 C17(Carbamidomethyl); 1 2909.239 2.76 signaling 11 C21(Carbamidomethyl) N-Term(Dimethyl); GTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 3 1716.763 3.99 C12(Carbamidomethyl) N-Term(Dimethyl); M5(Oxidation); GTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 1 1732.762 2.46 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 2 1724.819 3.36 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 1 1740.810 3.37 M5(Oxidation); C12(Carbamidomethyl)

N-Term(Dimethyl); GTDIMYTGTLDCWRK P51881 ADP/ATP translocase 2 6 1872.892 3.80 C12(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTDIMYTGTLDCWRK P51881 ADP/ATP translocase 2 C12(Carbamidomethyl); 11 1888.983 3.99 K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTDIMYTGTLDCWRK P51881 ADP/ATP translocase 2 M5(Oxidation); C12(Carbamidomethyl); 1 1904.972 2.23 K15(HeavyDimethyl)

N-Term(Dimethyl); GTFASLSELHCDK A8DUK4 Beta-globin 18 1520.739 3.73 C11(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTFASLSELHCDK A8DUK4 Beta-globin C11(Carbamidomethyl); 14 1536.826 4.47 K13(HeavyDimethyl) N-Term(Dimethyl); GTFASLSELHCDKLHVDPENFR A8DUK4 Beta-globin 21 2628.289 4.38 C11(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTFASLSELHCDKLHVDPENFR A8DUK4 Beta-globin C11(Carbamidomethyl); 16 2644.361 5.21 K13(HeavyDimethyl) Isoform 2 of 4- aminobutyrate N-Term(Dimethyl); GTFCSFDTPDEAIR P61922-2 5 1643.730 3.79 aminotransferase, C4(Carbamidomethyl) mitochondrial Isoform 2 of 4- aminobutyrate N-Term(Dimethyl:2H(6)13C(2)); GTFCSFDTPDEAIR P61922-2 7 1651.775 4.45 aminotransferase, C4(Carbamidomethyl) mitochondrial Isoform 2 of 4- aminobutyrate N-Term(Dimethyl); GTFCSFDTPDEAIRNK P61922-2 1 1913.907 2.25 aminotransferase, C4(Carbamidomethyl); K16(Dimethyl) mitochondrial Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate GTFCSFDTPDEAIRNK P61922-2 C4(Carbamidomethyl); 3 1929.988 2.50 aminotransferase, K16(HeavyDimethyl) mitochondrial DnaJ homolog subfamily GTISVGVDATDLFDRYDEEYEDVSGSG N-Term(Dimethyl:2H(6)13C(2)); A2A8D1 C member 11 1 4406.208 2.91 FPQIEINKMHIS K35(HeavyDimethyl) (Fragment) GTNTGVWVGVSGSEASEALSRDPETL N-Term(Dimethyl); P19096 Fatty acid synthase 1 3798.801 3.21 LGYSMVGCQR C34(Carbamidomethyl) GTNTGVWVGVSGSEASEALSRDPETL N-Term(Dimethyl:2H(6)13C(2)); P19096 Fatty acid synthase 3 3806.870 4.10 LGYSMVGCQR C34(Carbamidomethyl) Nicotinate N-Term(Dimethyl); GTQEPCTVKPAQVEPLLR Q8CC86 phosphoribosyltransferas 5 2079.129 4.03 C6(Carbamidomethyl); K9(Dimethyl) e Nicotinate N-Term(Dimethyl:2H(6)13C(2)); GTQEPCTVKPAQVEPLLR Q8CC86 phosphoribosyltransferas C6(Carbamidomethyl); 1 2095.216 3.18 e K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTSGNVALLELGCGTGANFQFYPQGC Methyltransferase-like C13(Carbamidomethyl); Q9DD20 1 2918.482 4.67 K protein 7B C26(Carbamidomethyl); K27(HeavyDimethyl) GTSLMEDDEEPIVEDVMMSSEGR O35638 Cohesin subunit SA-2 N-Term(Dimethyl); M17(Oxidation) 1 2600.141 2.29 GTSPTQIWCNNSQLPVDHILAGSFETA N-Term(Dimethyl:2H(6)13C(2)); Q8CIE6 Coatomer subunit alpha 1 3266.603 3.09 MR C9(Carbamidomethyl) N-Term(Dimethyl); GTVCAANDFNPDADAK F8WIT2 Annexin 8 1721.772 5.30 C4(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GTVCAANDFNPDADAK F8WIT2 Annexin C4(Carbamidomethyl); 1 1737.868 3.91 K16(HeavyDimethyl) Low-density lipoprotein GTYFPAILNPPPSPATER E9Q8K0 receptor-related protein 1 1927.967 2.19 6 Cytochrome b-c1 GVAGALRPLLQGAVPAASEPPVLDVK N-Term(Dimethyl); K26(Dimethyl); Q9CR68 complex subunit Rieske, 1 3410.939 3.08 RPFLCR C31(Carbamidomethyl) mitochondrial N-Term(Dimethyl); GVASVCVEDWNNRK P01872 Ig mu chain C region 2 1689.836 2.42 C6(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ras-related protein Rab- GVDLQESNPASRSQCCSN P35278 C15(Carbamidomethyl); 1 2044.921 2.51 5C C16(Carbamidomethyl) Tyrosine--tRNA ligase, GVDSQGMLLCASVEGVSR Q91WQ3 C10(Carbamidomethyl) 1 1864.906 2.23 cytoplasmic Tyrosine--tRNA ligase, GVDSQGMLLCASVEGVSR Q91WQ3 M7(Oxidation); C10(Carbamidomethyl) 1 1880.900 2.12 cytoplasmic N-Term(Dimethyl); GVDVSQVTWQSQGDTPCSCCIVNNSN C17(Carbamidomethyl); P97328 Ketohexokinase 2 3240.416 4.42 GSR C19(Carbamidomethyl); C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GVDVSQVTWQSQGDTPCSCCIVNNSN C17(Carbamidomethyl); P97328 Ketohexokinase 1 3248.464 6.16 GSR C19(Carbamidomethyl); C20(Carbamidomethyl) N-Term(Dimethyl); GVEERIQEEAGCLIK P56593 Cytochrome P450 2A12 1 1786.931 2.42 C12(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GVEERIQEEAGCLIK P56593 Cytochrome P450 2A12 C12(Carbamidomethyl); 1 1803.020 2.42 K15(HeavyDimethyl) UDP- N-Term(Dimethyl); GVFCDYLEEGAQCPSLPSYVPR Q62452 glucuronosyltransferase C4(Carbamidomethyl); 3 2572.194 3.89 1-9 C13(Carbamidomethyl) UDP- N-Term(Dimethyl:2H(6)13C(2)); GVFCDYLEEGAQCPSLPSYVPR Q62452 glucuronosyltransferase C4(Carbamidomethyl); 1 2580.233 3.81 1-9 C13(Carbamidomethyl) Succinate dehydrogenase N-Term(Dimethyl); GVIALCIEDGSIHR Q8K2B3 [ubiquinone] 7 1567.823 3.46 C6(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); GVIALCIEDGSIHR Q8K2B3 [ubiquinone] 2 1575.873 2.74 C6(Carbamidomethyl) flavoprotein subunit, mitochondrial Serine/arginine GVITGSGSAADLFSK F6V5T7 repetitive matrix protein K15(HeavyDimethyl) 1 1445.783 1.97 4 (Fragment) 4- N-Term(Dimethyl); K3(Dimethyl); GVKPITLELGGKSPLIIFSDCNMENAVK Q9JLJ2 trimethylaminobutyralde K12(Dimethyl); C21(Carbamidomethyl); 2 3142.738 3.87 hyde dehydrogenase K28(Dimethyl) Isoform Cytoplasmic+peroxisom N-Term(Dimethyl); GVLFGVPGAFTPGCSK P99029-2 2 1649.876 3.09 al of Peroxiredoxin-5, C14(Carbamidomethyl); K16(Dimethyl) mitochondrial Isoform N-Term(Dimethyl:2H(6)13C(2)); Cytoplasmic+peroxisom GVLFGVPGAFTPGCSK P99029-2 C14(Carbamidomethyl); 6 1665.948 3.65 al of Peroxiredoxin-5, K16(HeavyDimethyl) mitochondrial Isoform N-Term(Dimethyl); GVLFGVPGAFTPGCSKTHLPGFVEQAG Cytoplasmic+peroxisom P99029-2 C14(Carbamidomethyl); K16(Dimethyl); 1 3126.686 2.96 ALK al of Peroxiredoxin-5, K30(Dimethyl) mitochondrial Isoform N-Term(Dimethyl:2H(6)13C(2)); GVLFGVPGAFTPGCSKTHLPGFVEQAG Cytoplasmic+peroxisom C14(Carbamidomethyl); P99029-2 3 3150.827 3.00 ALK al of Peroxiredoxin-5, K16(HeavyDimethyl); mitochondrial K30(HeavyDimethyl) Transitional N-Term(Dimethyl); GVLFYGPPGCGK Q01853 endoplasmic reticulum 6 1307.677 3.38 C10(Carbamidomethyl); K12(Dimethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); GVLFYGPPGCGK Q01853 endoplasmic reticulum C10(Carbamidomethyl); 2 1323.768 2.54 ATPase K12(HeavyDimethyl) ATP-binding cassette N-Term(Dimethyl:2H(6)13C(2)); GVLLSTHDLAEAEALCDR Q8K441 2 2006.053 3.02 sub-family A member 6 C16(Carbamidomethyl) Mitochondrial glutamate N-Term(Dimethyl); GVNEDTYSGFLDCAR E9Q6M6 6 1731.759 4.93 carrier 1 C13(Carbamidomethyl) Mitochondrial glutamate N-Term(Dimethyl:2H(6)13C(2)); GVNEDTYSGFLDCAR E9Q6M6 4 1739.799 4.59 carrier 1 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GVNSFQMFMTYKDLYMLRDSELYQV Dihydropyrimidinase- Q9EQF6 K12(HeavyDimethyl); 2 3821.875 3.22 FHACR related protein 5 C29(Carbamidomethyl) N-Term(Dimethyl); M12(Oxidation); GVPALIENDQHMNCIR F8VPN4 Protein Agl 1 1910.914 2.93 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GVPALIENDQHMNCIR F8VPN4 Protein Agl 2 1902.965 3.24 C14(Carbamidomethyl) N-Term(Dimethyl); K20(Dimethyl); GVQDIVVGEGTHFLIPWVQKPIIFDCR Q5SQG5 Prohibitin (Fragment) 16 3179.714 5.28 C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GVQDIVVGEGTHFLIPWVQKPIIFDCR Q5SQG5 Prohibitin (Fragment) K20(HeavyDimethyl); 9 3195.814 5.19 C26(Carbamidomethyl) ATP-binding cassette GVSAAAMGPERERLIR Q91V24 N-Term(Dimethyl); M7(Oxidation) 1 1756.929 2.54 sub-family A member 7 N-Term(Dimethyl); Formimidoyltransferase- GVSMEECVLCAK Q91XD4 C7(Carbamidomethyl); 1 1438.671 2.96 cyclodeaminase C10(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Formimidoyltransferase- C7(Carbamidomethyl); GVSMEECVLCAK Q91XD4 5 1454.763 3.13 cyclodeaminase C10(Carbamidomethyl); K12(HeavyDimethyl) Mitochondrial N-Term(Dimethyl); GVSVCETECTDMGLR Q922Q1 amidoxime reducing C5(Carbamidomethyl); 9 1741.747 4.09 component 2 C9(Carbamidomethyl) Mitochondrial N-Term(Dimethyl); GVSVCETECTDMGLR Q922Q1 amidoxime reducing C5(Carbamidomethyl); 1 1757.743 3.93 component 2 C9(Carbamidomethyl); M12(Oxidation) Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GVSVCETECTDMGLR Q922Q1 amidoxime reducing C5(Carbamidomethyl); 12 1749.791 4.12 component 2 C9(Carbamidomethyl) Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GVSVCETECTDMGLR Q922Q1 amidoxime reducing C5(Carbamidomethyl); 1 1765.785 3.34 component 2 C9(Carbamidomethyl); M12(Oxidation)

N-Term(Dimethyl); K14(Dimethyl); GVTIIGPATVGGIKPGCFK Q91V92 ATP-citrate synthase 2 1956.138 4.12 C17(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K14(HeavyDimethyl); GVTIIGPATVGGIKPGCFK Q91V92 ATP-citrate synthase 1 1980.277 2.91 C17(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl); GVVCDKREPDGIR Q9CXF0 Kynureninase 1 1556.822 2.65 C4(Carbamidomethyl); K6(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); GVVCDKREPDGIR Q9CXF0 Kynureninase C4(Carbamidomethyl); 2 1572.911 2.73 K6(HeavyDimethyl) Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate GVVLGGCGDK P61922-2 C7(Carbamidomethyl); 3 1033.627 2.16 aminotransferase, K10(HeavyDimethyl) mitochondrial Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate GVVLGGCGDKSIR P61922-2 C7(Carbamidomethyl); 2 1389.846 2.39 aminotransferase, K10(HeavyDimethyl) mitochondrial 2-hydroxyacyl-CoA N-Term(Dimethyl); GVVPDNHPNCVGAAR D3YZ54 11 1590.774 3.11 lyase 1 C10(Carbamidomethyl) 2-hydroxyacyl-CoA N-Term(Dimethyl:2H(6)13C(2)); GVVPDNHPNCVGAAR D3YZ54 8 1598.819 4.04 lyase 1 C10(Carbamidomethyl) Isoform Cytoplasmic of N-Term(Dimethyl:2H(6)13C(2)); GVYAVGDVCGK P47791-2 Glutathione reductase, C9(Carbamidomethyl); 4 1196.694 2.42 mitochondrial K11(HeavyDimethyl) Isoform 2 of Tudor N-Term(Dimethyl); M9(Oxidation); GWNAEQNGMKDGTQSR Q91W18-2 domain-containing 1 1850.851 2.31 K10(Dimethyl) protein 3 Acyl-CoA synthetase N-Term(Dimethyl); GYCVMQGYWGEPQK Q8VCW8 family member 2, 1 1758.792 2.60 C3(Carbamidomethyl); K14(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); GYDYGPQFQGICEATLEGEQGK P19096 Fatty acid synthase C12(Carbamidomethyl); 1 2519.236 2.98 K22(HeavyDimethyl) N-Term(Dimethyl); GYEVIYLTEPVDEYCIQALPEFDGKR F7C312 Endoplasmin (Fragment) 1 3160.568 2.99 C15(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl); GYFEDRRPSANCDPYAVTEAIVR P15105 Glutamine synthetase 2 2714.300 2.71 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); GYFEDRRPSANCDPYAVTEAIVR P15105 Glutamine synthetase 3 2722.341 3.31 C12(Carbamidomethyl) Glutaryl-CoA N-Term(Dimethyl); GYGCAGVSSVAYGLLTR Q60759 dehydrogenase, 9 1758.873 5.31 C4(Carbamidomethyl) mitochondrial Glutaryl-CoA N-Term(Dimethyl:2H(6)13C(2)); GYGCAGVSSVAYGLLTR Q60759 dehydrogenase, 8 1766.936 5.03 C4(Carbamidomethyl) mitochondrial Malate dehydrogenase, N-Term(Dimethyl); GYLGPEQLPDCLK P08249 7 1545.797 3.39 mitochondrial C11(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, GYLGPEQLPDCLK P08249 C11(Carbamidomethyl); 2 1561.884 3.19 mitochondrial K13(HeavyDimethyl) N-Term(Dimethyl); Malate dehydrogenase, GYLGPEQLPDCLKGCDVVVIPAGVPR P08249 C11(Carbamidomethyl); K13(Dimethyl); 3 2865.502 4.36 mitochondrial C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, C11(Carbamidomethyl); GYLGPEQLPDCLKGCDVVVIPAGVPR P08249 8 2881.584 4.64 mitochondrial K13(HeavyDimethyl); C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Citrate synthase, GYSIPECQK Q9CZU6 C7(Carbamidomethyl); 2 1153.648 2.30 mitochondrial K9(HeavyDimethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); GYVSCALGCPYEGK P38060 CoA lyase, C5(Carbamidomethyl); 6 1616.738 3.08 mitochondrial C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxymethylglutaryl- C5(Carbamidomethyl); GYVSCALGCPYEGK P38060 CoA lyase, 9 1632.824 4.51 C9(Carbamidomethyl); mitochondrial K14(HeavyDimethyl) N-Term(Dimethyl); Hydroxymethylglutaryl- C5(Carbamidomethyl); GYVSCALGCPYEGKVSPAK P38060 CoA lyase, 9 2127.056 5.50 C9(Carbamidomethyl); K14(Dimethyl); mitochondrial K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxymethylglutaryl- C5(Carbamidomethyl); GYVSCALGCPYEGKVSPAK P38060 CoA lyase, C9(Carbamidomethyl); 6 2151.185 5.69 mitochondrial K14(HeavyDimethyl); K19(HeavyDimethyl) Glutamate--cysteine N-Term(Dimethyl); GYVSDIDCR P97494 1 1112.505 2.24 ligase catalytic subunit C8(Carbamidomethyl) HAFSPVASVESASGETLHSPKVGQPGA Alpha-2-HS- N-Term(Dimethyl); K21(Dimethyl); P29699 3 3812.876 6.34 AGPVSPMCPGR glycoprotein C35(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); HAFSPVASVESASGETLHSPKVGQPGA Alpha-2-HS- P29699 K21(HeavyDimethyl); 1 3828.972 4.36 AGPVSPMCPGR glycoprotein C35(Carbamidomethyl) HAQPWMESVHCQFMGSLAILSTEVSV C11(Carbamidomethyl); Q6R6I7 Relaxin receptor 1 1 4152.119 3.05 LLLTFLTLEK K36(HeavyDimethyl) Isoform 1S of Ral HCSPQFFSLGLPGATMLIMDFIIAAGRV N-Term(Dimethyl); Q6GYP7-6 GTPase-activating 1 4108.121 3.08 ASSAFLNAPR C2(Carbamidomethyl); M19(Oxidation) protein subunit alpha-1 N-Term(Dimethyl:2H(6)13C(2)); HDALYVVGALDEAMELR B7ZMZ7 Dip2c protein 1 1954.036 2.22 M14(Oxidation) HDIDLQQPSAEASPNPEILTGSTDFPLSS Immunoglobulin Q3V1M1 1 4231.047 2.82 LLTSTPMPAPR superfamily member 10

N-Term(Dimethyl:2H(6)13C(2)); HDIMVVAVCMVALVLLLVLGMWGTY Pro-epidermal growth P01132 M4(Oxidation); C9(Carbamidomethyl); 1 3369.743 2.80 YYR factor M10(Oxidation); M21(Oxidation) Isoform 6 of Inositol hexakisphosphate and K4(Dimethyl); M15(Oxidation); HDLKIYASDEGRVQMTAAAFAK A2ARP1-7 diphosphoinositol- 1 2494.267 2.50 K22(Dimethyl) pentakisphosphate kinase 1 C17(Carbamidomethyl); HDRDIALLDLINFFIQCSGCK O35638 Cohesin subunit SA-2 C20(Carbamidomethyl); 1 2571.350 2.61 K21(HeavyDimethyl) Receptor-type tyrosine- N-Term(Dimethyl:2H(6)13C(2)); HEKTVDIYGHVTCMR F6Y3V0 protein phosphatase F K3(HeavyDimethyl); 1 1918.053 2.48 (Fragment) C13(Carbamidomethyl) Aldehyde C7(Carbamidomethyl); HEPVGVCGQIIPWNFPLLMQAWK P47738 dehydrogenase, 2 2756.467 3.00 K23(HeavyDimethyl) mitochondrial Aldehyde N-Term(Dimethyl); HEPVGVCGQIIPWNFPLLMQAWK P47738 dehydrogenase, 5 2776.450 3.24 C7(Carbamidomethyl); K23(Dimethyl) mitochondrial Aldehyde N-Term(Dimethyl:2H(6)13C(2)); HEPVGVCGQIIPWNFPLLMQAWK P47738 dehydrogenase, C7(Carbamidomethyl); 1 2792.542 3.06 mitochondrial K23(HeavyDimethyl) HEQNIDCGGGYVK P14211 Calreticulin C7(Carbamidomethyl); K13(Dimethyl) 1 1504.683 2.11 C7(Carbamidomethyl); HEQNIDCGGGYVK P14211 Calreticulin 1 1512.722 2.86 K13(HeavyDimethyl) N-Term(Dimethyl); HEQNIDCGGGYVK P14211 Calreticulin 1 1532.711 2.88 C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); HEQNIDCGGGYVK P14211 Calreticulin C7(Carbamidomethyl); 1 1548.801 2.77 K13(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Rho-related GTP- C3(Carbamidomethyl); HFCPNVPIILVGNKK H3BL56 2 1844.199 3.17 binding protein RhoC K14(HeavyDimethyl); K15(HeavyDimethyl) Isoform 2 of HFEGGVKLGVGAFNLTLSMLPTRILR A2ACP1-2 Tetratricopeptide repeat K7(HeavyDimethyl) 1 2862.618 2.23 protein 39A Aspartate C10(Carbamidomethyl); HFIEQGINVCLCQSYAK P05202 aminotransferase, 1 2095.000 3.16 C12(Carbamidomethyl); K17(Dimethyl) mitochondrial Aspartate C10(Carbamidomethyl); HFIEQGINVCLCQSYAK P05202 aminotransferase, C12(Carbamidomethyl); 5 2103.050 4.84 mitochondrial K17(HeavyDimethyl) Aspartate N-Term(Dimethyl); HFIEQGINVCLCQSYAK P05202 aminotransferase, C10(Carbamidomethyl); 9 2123.038 5.06 mitochondrial C12(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aspartate C10(Carbamidomethyl); HFIEQGINVCLCQSYAK P05202 aminotransferase, 6 2139.131 5.52 C12(Carbamidomethyl); mitochondrial K17(HeavyDimethyl) Family with sequence N-Term(Dimethyl); HFNDPDNITECLQGKMVYLFGDSTIR B9EKK6 1 3126.546 2.90 similarity 55, member C C11(Carbamidomethyl); K15(Dimethyl)

HFNIVTINEFSDKSMFTIFSRILAWHLR L7N1Y0 Protein Dnah7b N-Term(Dimethyl); K13(Dimethyl) 1 3478.893 2.95

L-serine dehydratase/L- HFVCSSAGNAGMATAYAAR D3Z221 threonine deaminase C4(Carbamidomethyl) 4 1941.860 4.26 (Fragment)

L-serine dehydratase/L- N-Term(Dimethyl); HFVCSSAGNAGMATAYAAR D3Z221 threonine deaminase 9 1969.896 4.58 C4(Carbamidomethyl) (Fragment) L-serine dehydratase/L- N-Term(Dimethyl:2H(6)13C(2)); HFVCSSAGNAGMATAYAAR D3Z221 threonine deaminase 2 1977.941 3.06 C4(Carbamidomethyl) (Fragment) 4- K6(Dimethyl); C15(Carbamidomethyl); HGDGVKDIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate 9 2467.182 4.79 K21(Dimethyl) dioxygenase 4- K6(HeavyDimethyl); HGDGVKDIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate C15(Carbamidomethyl); 12 2483.274 7.10 dioxygenase K21(HeavyDimethyl) 4- N-Term(Dimethyl); K6(Dimethyl); HGDGVKDIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate 19 2495.219 6.95 C15(Carbamidomethyl); K21(Dimethyl) dioxygenase N-Term(Dimethyl:2H(6)13C(2)); 4- K6(HeavyDimethyl); HGDGVKDIAFEVEDCDHIVQK P49429 hydroxyphenylpyruvate 7 2519.351 6.84 C15(Carbamidomethyl); dioxygenase K21(HeavyDimethyl) MTSS1-like protein N-Term(Dimethyl:2H(6)13C(2)); HGEEVSPAASDLAMVLTR F7D291 1 1935.015 2.26 (Fragment) M14(Oxidation) Isoform 2 of HGGEDYVFSLLTGYCEPPTGVSLR Q9D0M3-2 Cytochrome c1, heme C15(Carbamidomethyl) 6 2654.245 4.30 protein, mitochondrial Isoform 2 of N-Term(Dimethyl); HGGEDYVFSLLTGYCEPPTGVSLR Q9D0M3-2 Cytochrome c1, heme 8 2682.287 4.54 C15(Carbamidomethyl) protein, mitochondrial Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); HGGEDYVFSLLTGYCEPPTGVSLR Q9D0M3-2 Cytochrome c1, heme 3 2690.307 3.66 C15(Carbamidomethyl) protein, mitochondrial HGGSPTSLGTWGSWAGPDHDKFSAM Glucosidase 2 subunit N-Term(Dimethyl); K21(Dimethyl); O08795 1 4331.965 3.98 KYEQGTGCWQGPNR beta K26(Dimethyl); C33(Carbamidomethyl) HGICLAFVNMIPENMQIYMTRATIYDQ C4(Carbamidomethyl); D3Z3M1 Protein Gm20782 1 4111.995 2.65 QIMTSSAK K35(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K11(HeavyDimethyl); M12(Oxidation); Isoform 4 of Mediator of HGLSSGSSSTKMKPQGKPSSLMNPSIS K13(HeavyDimethyl); Q925J9-4 RNA polymerase II 1 4704.682 2.60 KPNISPSHSRPPGGSDK K17(HeavyDimethyl); transcription subunit 1 K28(HeavyDimethyl); K44(HeavyDimethyl) HGVDTHLFSVESPQELAAWTRQLVDG A2AKD7 Alpha-1-syntrophin C27(Carbamidomethyl) 1 3345.584 2.73 CHR HGYPLIGSLVYSVK Q52KP5 NXPE family member 4 K14(HeavyDimethyl) 1 1568.916 2.05 HHPNEADTSPGEWTNLPK J3QMK1 Protein Gm4975 N-Term(Dimethyl); K18(Dimethyl) 1 2085.976 2.67 Isoform 2 of HHSLQQPGRVPGCSNWGMAVNVYST Microtubule-associated N-Term(Dimethyl); Q8R001-2 1 3859.753 2.77 SITQETMSR protein RP/EB family C13(Carbamidomethyl); M18(Oxidation) member 2 Isoform 2 of Protein HHYMLCGALLRVWGRIAAVMADVSS N-Term(Dimethyl:2H(6)13C(2)); Q7TNB8-2 strawberry notch 1 3812.063 2.96 SSYLQIVR M4(Oxidation); C6(Carbamidomethyl) homolog 2 N-Term(Dimethyl:2H(6)13C(2)); Protein Jumonji HIAKPFSMEKLLYQIAQAE G3UZT8 K4(HeavyDimethyl); 1 2325.380 2.21 (Fragment) K10(HeavyDimethyl) Alcohol dehydrogenase C4(Carbamidomethyl); K19(Dimethyl); HIDCASVYGNETEIGEALKESVGSGK B1AXW3 1 2806.369 2.97 [NADP(+)] (Fragment) K26(Dimethyl) C4(Carbamidomethyl); Alcohol dehydrogenase HIDCASVYGNETEIGEALKESVGSGK B1AXW3 K19(HeavyDimethyl); 1 2822.456 2.60 [NADP(+)] (Fragment) K26(HeavyDimethyl) N-Term(Dimethyl); Alcohol dehydrogenase HIDCASVYGNETEIGEALKESVGSGK B1AXW3 C4(Carbamidomethyl); K19(Dimethyl); 1 2834.384 3.41 [NADP(+)] (Fragment) K26(Dimethyl) Methyltransferase-like N-Term(Dimethyl); HIGDGCHLTR Q9DD20 1 1193.585 2.45 protein 7B C6(Carbamidomethyl) K23(HeavyDimethyl); HISPDQLPVEYGGTMTDPDGNPKCK Q99J08 SEC14-like protein 2 C24(Carbamidomethyl); 1 2828.428 2.55 K25(HeavyDimethyl) N-Term(Dimethyl); K23(Dimethyl); HISPDQLPVEYGGTMTDPDGNPKCK Q99J08 SEC14-like protein 2 4 2840.354 3.72 C24(Carbamidomethyl); K25(Dimethyl)

N-Term(Dimethyl); M15(Oxidation); HISPDQLPVEYGGTMTDPDGNPKCK Q99J08 SEC14-like protein 2 K23(Dimethyl); C24(Carbamidomethyl); 1 2856.349 2.95 K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K23(HeavyDimethyl); HISPDQLPVEYGGTMTDPDGNPKCK Q99J08 SEC14-like protein 2 2 2864.478 3.65 C24(Carbamidomethyl); K25(HeavyDimethyl) Propionyl-CoA N-Term(Dimethyl); K2(Dimethyl); HKQEDIPISGWAVECR Q91ZA3 carboxylase alpha chain, 5 1980.989 4.22 C15(Carbamidomethyl) mitochondrial Propionyl-CoA N-Term(Dimethyl:2H(6)13C(2)); HKQEDIPISGWAVECR Q91ZA3 carboxylase alpha chain, K2(HeavyDimethyl); 1 1997.075 2.24 mitochondrial C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Propionyl-CoA K2(HeavyDimethyl); HKQEDIPISGWAVECRVYAEDPYK Q91ZA3 carboxylase alpha chain, 1 2998.572 2.89 C15(Carbamidomethyl); mitochondrial K24(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); HLGIVGECNIQFALHPTSMEYCIIEVNA Q8C196 synthase [ammonia], C8(Carbamidomethyl); 1 3407.727 3.45 R mitochondrial C22(Carbamidomethyl) ATP synthase subunit HLIIGVSSDRGLCGAIHSSVAK A2AKV0 gamma, mitochondrial C13(Carbamidomethyl); K22(Dimethyl) 2 2305.246 2.96 (Fragment)

ATP synthase subunit C13(Carbamidomethyl); HLIIGVSSDRGLCGAIHSSVAK A2AKV0 gamma, mitochondrial 1 2313.284 3.70 K22(HeavyDimethyl) (Fragment)

ATP synthase subunit N-Term(Dimethyl); HLIIGVSSDRGLCGAIHSSVAK A2AKV0 gamma, mitochondrial 2 2333.276 2.74 C13(Carbamidomethyl); K22(Dimethyl) (Fragment)

ATP synthase subunit N-Term(Dimethyl:2H(6)13C(2)); HLIIGVSSDRGLCGAIHSSVAK A2AKV0 gamma, mitochondrial C13(Carbamidomethyl); 2 2349.361 2.58 (Fragment) K22(HeavyDimethyl)

N-Term(Dimethyl); K3(Dimethyl); HLKPGDRVAIEPGVPREVDEYCK Q64442 Sorbitol dehydrogenase 4 2748.440 3.30 C22(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); HLKPGDRVAIEPGVPREVDEYCK Q64442 Sorbitol dehydrogenase 1 2772.579 3.02 C22(Carbamidomethyl); K23(HeavyDimethyl) C8(Carbamidomethyl); HLLPLVQCPTLIVHGEKDPLVPR Q8R164 Valacyclovir hydrolase 1 2667.560 2.99 K17(HeavyDimethyl) N-Term(Dimethyl); HLLPLVQCPTLIVHGEKDPLVPR Q8R164 Valacyclovir hydrolase 1 2687.561 3.14 C8(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); HLLPLVQCPTLIVHGEKDPLVPR Q8R164 Valacyclovir hydrolase C8(Carbamidomethyl); 1 2703.639 3.17 K17(HeavyDimethyl) Isoform 2 of Zinc finger C12(Carbamidomethyl); HLRTHGAAPYRCPLCR Q9JKD9-2 and BTB domain- 2 1964.981 2.36 C15(Carbamidomethyl) containing protein 32 N-Term(Dimethyl:2H(6)13C(2)); M13(Oxidation); HLSDVGIGHLAGMTRSAAEGCLGLEQ F-box/LRR-repeat Q8BID8 C21(Carbamidomethyl); 1 3753.971 3.19 LTLQDCQK protein 14 C32(Carbamidomethyl); K34(HeavyDimethyl) C12(Carbamidomethyl); HLSRVLLFLSQCYILSGDESTEIPPYMT TM2 domain-containing M27(Oxidation); K29(HeavyDimethyl); D3Z3H7 1 4481.223 3.08 KCPSNGLCSR protein 3 (Fragment) C30(Carbamidomethyl); C36(Carbamidomethyl) K12(HeavyDimethyl); HLTPVTLELGGKSPCYIDRDCDLDVAC Fatty aldehyde C15(Carbamidomethyl); P47740 1 3296.621 2.86 R dehydrogenase C21(Carbamidomethyl); C27(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); HLVGVCYTEEEAK Q9D0M3-2 Cytochrome c1, heme 2 1590.783 2.69 C6(Carbamidomethyl); K13(Dimethyl) protein, mitochondrial Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); HLVGVCYTEEEAK Q9D0M3-2 Cytochrome c1, heme C6(Carbamidomethyl); 1 1606.874 2.02 protein, mitochondrial K13(HeavyDimethyl) HLVHLDWMSREDGSHILTVGIGSKLF K24(HeavyDimethyl); Q6PNC0 DmX-like protein 1 1 3854.998 2.85 MYGPMAGK K34(HeavyDimethyl) Isoform 3 of Protein- HMANQLLAKFEENTRNPSVVK Q8BML1-3 methionine sulfoxide K9(Dimethyl); K21(Dimethyl) 2 2482.299 3.02 oxidase MICAL2 Isoform 3 of Protein- K9(HeavyDimethyl); HMANQLLAKFEENTRNPSVVK Q8BML1-3 methionine sulfoxide 1 2498.387 2.49 K21(HeavyDimethyl) oxidase MICAL2 Vascular endothelial HPFINKPDTLLVNR P35917 K6(Dimethyl) 1 1691.935 2.28 growth factor receptor 3 HPLYQLLNCGPGNRHSVLRSDIAHME N-Term(Dimethyl:2H(6)13C(2)); E9QAF4 Protein Phldb3 1 3206.662 2.83 R C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Tyrosine-protein HPPIVVHCSAGVGRTGVVILSELMIYC C8(Carbamidomethyl); M24(Oxidation); Q62130 phosphatase non- 1 3803.042 3.26 LEHNEK C27(Carbamidomethyl); receptor type 14 K33(HeavyDimethyl)

HPQHYPLMFCHVAGSPEQDMSMTSW Helicase with zinc finger C10(Carbamidomethyl); A2AS05 1 4578.141 2.85 LNSAEVTQVVEKVR domain 2 M20(Oxidation); K37(HeavyDimethyl)

Cytoplasmic C4(Carbamidomethyl); HPRCPPKGNMPK P70166 polyadenylation element- K7(HeavyDimethyl); M10(Oxidation); 1 1506.838 2.01 binding protein 1 K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); FAD-linked sulfhydryl HRDDTTPAAAPAPQGLEHGKRPCR P56213 K20(HeavyDimethyl); 1 2710.453 3.44 oxidase ALR C23(Carbamidomethyl) N-Term(Dimethyl); HRLGPNYLQIPVNCPYR P24270 Catalase 1 2125.106 2.85 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); HRLGPNYLQIPVNCPYR P24270 Catalase 1 2133.155 2.52 C14(Carbamidomethyl) Growth/differentiation N-Term(Dimethyl:2H(6)13C(2)); HRYGSPVHTMVQNIIYEK Q07105 1 2260.232 2.74 factor 9 M10(Oxidation); K18(HeavyDimethyl) HSELSELNVKVMEALSLYTKLMNEDP Signal transducing K10(Dimethyl); K20(Dimethyl); Q3UGN9 1 3964.991 2.82 MYSMYAK adapter molecule 1 M30(Oxidation); K33(Dimethyl) Electron transfer HSMNPFCEIAVEEAVR Q9DCW4 C7(Carbamidomethyl) 8 1888.858 3.60 flavoprotein subunit beta

Electron transfer HSMNPFCEIAVEEAVR Q9DCW4 M3(Oxidation); C7(Carbamidomethyl) 4 1904.860 3.82 flavoprotein subunit beta

Electron transfer N-Term(Dimethyl); HSMNPFCEIAVEEAVR Q9DCW4 1 1916.903 3.35 flavoprotein subunit beta C7(Carbamidomethyl)

Electron transfer N-Term(Dimethyl); M3(Oxidation); HSMNPFCEIAVEEAVR Q9DCW4 2 1932.887 2.33 flavoprotein subunit beta C7(Carbamidomethyl)

Electron transfer N-Term(Dimethyl:2H(6)13C(2)); HSMNPFCEIAVEEAVR Q9DCW4 4 1924.939 2.53 flavoprotein subunit beta C7(Carbamidomethyl) Electron transfer N-Term(Dimethyl:2H(6)13C(2)); HSMNPFCEIAVEEAVR Q9DCW4 1 1940.935 2.77 flavoprotein subunit beta M3(Oxidation); C7(Carbamidomethyl) N-Term(Dimethyl); Electron transfer HSMNPFCEIAVEEAVRLKEK Q9DCW4 C7(Carbamidomethyl); K18(Dimethyl); 1 2471.276 2.69 flavoprotein subunit beta K20(Dimethyl) Isoform 3 of FCH N-Term(Dimethyl:2H(6)13C(2)); HSPVQMNRNSSSK Q3UQN2-3 1 1543.855 1.93 domain only protein 2 K13(HeavyDimethyl) BMP and activin C14(Carbamidomethyl); HSSYFFIWLQLELCAMAVLLTK Q9D0L6 membrane-bound 1 2714.435 2.97 M16(Oxidation); K22(Dimethyl) inhibitor homolog Peptidyl-prolyl cis-trans C24(Carbamidomethyl); HTGPGILSMANAGPNTNGSQFFICTAK P17742 2 2827.407 4.03 isomerase A K27(HeavyDimethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl); HTGPGILSMANAGPNTNGSQFFICTAK P17742 4 2847.392 4.04 isomerase A C24(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); HTNSQFLYFAPDLVFNEEKMHQSAMY Mineralocorticoid D3Z473 K19(HeavyDimethyl); 1 4094.012 2.78 ELCQGMR receptor C29(Carbamidomethyl) HTTSYPPLCYQNPEAALR Q8VCC2 Liver carboxylesterase 1 C9(Carbamidomethyl) 2 2118.010 3.00 N-Term(Dimethyl); HTTSYPPLCYQNPEAALR Q8VCC2 Liver carboxylesterase 1 2 2146.035 2.72 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); HTTSYPPLCYQNPEAALR Q8VCC2 Liver carboxylesterase 1 4 2154.083 3.10 C9(Carbamidomethyl) HVHAFIHTPTGTHFCEVEQMR D3Z4U1 Uricase C15(Carbamidomethyl) 6 2534.176 3.28 HVHAFIHTPTGTHFCEVEQMR P25688 Uricase C15(Carbamidomethyl); M20(Oxidation) 2 2550.177 2.66 N-Term(Dimethyl); HVHAFIHTPTGTHFCEVEQMR D3Z4U1 Uricase 15 2562.202 5.25 C15(Carbamidomethyl) N-Term(Dimethyl); HVHAFIHTPTGTHFCEVEQMR D3Z4U1 Uricase 1 2578.202 2.98 C15(Carbamidomethyl); M20(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); HVHAFIHTPTGTHFCEVEQMR D3Z4U1 Uricase 8 2570.246 4.86 C15(Carbamidomethyl) Succinate dehydrogenase HVNGQDQIVPGLYACGEAACASVHGA C15(Carbamidomethyl); Q8K2B3 [ubiquinone] 2 2951.372 3.70 NR C20(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl); HVNGQDQIVPGLYACGEAACASVHGA Q8K2B3 [ubiquinone] C15(Carbamidomethyl); 5 2979.389 4.68 NR flavoprotein subunit, C20(Carbamidomethyl) mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); HVNGQDQIVPGLYACGEAACASVHGA Q8K2B3 [ubiquinone] C15(Carbamidomethyl); 1 2987.433 4.53 NR flavoprotein subunit, C20(Carbamidomethyl) mitochondrial HVNIYYYLEDDSMSVIEPVVENSGIPQ EF-hand domain M13(Oxidation); K29(Dimethyl); B2CKC6 1 3721.953 2.88 GKLIK containing 1 K32(Dimethyl) Thiosulfate HVPGASFFDIEECR P52196 C13(Carbamidomethyl) 3 1663.750 2.30 sulfurtransferase Thiosulfate N-Term(Dimethyl); HVPGASFFDIEECR P52196 4 1691.779 2.85 sulfurtransferase C13(Carbamidomethyl) Thiosulfate N-Term(Dimethyl:2H(6)13C(2)); HVPGASFFDIEECR P52196 4 1699.819 2.52 sulfurtransferase C13(Carbamidomethyl) HVWFGESMNGGFQFSYGPPDLPEDVV Collagen alpha-1(III) N-Term(Dimethyl:2H(6)13C(2)); P08121 1 3905.872 2.88 DVQLAFLR chain M8(Oxidation) Sarcosine N-Term(Dimethyl); HWHADLRPDDSPLEAGLAFTCK Q99LB7 dehydrogenase, 1 2592.264 2.87 C21(Carbamidomethyl); K22(Dimethyl) mitochondrial Isoform 2 of Elongation C7(Carbamidomethyl); HYAHTDCPGHADYVK Q8BFR5-2 1 1806.843 2.89 factor Tu, mitochondrial K15(HeavyDimethyl)

C4(Carbamidomethyl); M17(Oxidation); HYDCSSSEPQDVTILSMLVSSGSCGVT Q0GGX2 Zinc finger protein 541 C24(Carbamidomethyl); 1 4933.312 2.94 PVVLSSLLQGQEKDGEER K40(HeavyDimethyl) N-Term(Dimethyl); IAAELNCDPTDER A2ARD7 Kynureninase 2 1531.700 2.78 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); IAAELNCDPTDER A2ARD7 Kynureninase 4 1539.746 3.02 C7(Carbamidomethyl) Signal recognition N-Term(Dimethyl:2H(6)13C(2)); IAASLQSQSPEYLLPVLIQAAQLCR E9Q740 1 2805.578 2.81 particle subunit SRP72 C24(Carbamidomethyl) Fructose-bisphosphate IADQCPSSLAIQENANALAR Q91Y97 C5(Carbamidomethyl) 6 2142.058 5.58 aldolase B Fructose-bisphosphate N-Term(Dimethyl); IADQCPSSLAIQENANALAR Q91Y97 59 2170.095 7.84 aldolase B C5(Carbamidomethyl)

Fructose-bisphosphate N-Term(Dimethyl:2H(6)13C(2)); IADQCPSSLAIQENANALAR Q91Y97 61 2178.128 7.85 aldolase B C5(Carbamidomethyl) Adenosylhomocysteinas IAGCLHMTVETAVLIETLVALGAEVR P50247 C4(Carbamidomethyl) 1 2766.496 2.56 e N-Term(Dimethyl); K4(Dimethyl); IAIKILVHSLFSMLIMCTILTNCVFMTLS A2ASI5 Protein Scn3a C17(Carbamidomethyl); 1 4292.261 3.19 NPPDWTK C23(Carbamidomethyl); K36(Dimethyl) N-Term(Dimethyl); T-complex protein 1 IAILTCPFEPPKPK P80316 C6(Carbamidomethyl); K12(Dimethyl); 1 1694.990 2.63 subunit epsilon K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 C6(Carbamidomethyl); IAILTCPFEPPKPK P80316 1 1719.128 2.49 subunit epsilon K12(HeavyDimethyl); K14(HeavyDimethyl) N-Term(Dimethyl); K3(Dimethyl); IAKDRDNHCGLATAASYPVVN P06797 Cathepsin L1 1 2328.182 2.54 C9(Carbamidomethyl) Dihydropyrimidine N-Term(Dimethyl); IALFGAGPASISCASFLAR Q8CHR6 dehydrogenase 4 1937.033 4.03 C13(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); IALFGAGPASISCASFLAR Q8CHR6 dehydrogenase 2 1945.081 3.42 C13(Carbamidomethyl) [NADP(+)] IAQLASIAGPQSRVAQPETPVTLQFQG E1A-binding protein N-Term(Dimethyl:2H(6)13C(2)); F6R9G0 1 4191.309 3.09 NKFTLSHSQLR p400 (Fragment) K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 3 of C6(Carbamidomethyl); IASFTCKAGTSCDSGIMGLRK Q3U3D7-3 Transmembrane protein K7(HeavyDimethyl); 1 2368.297 2.35 131-like C12(Carbamidomethyl); K21(HeavyDimethyl) Isoform 2 of Zinc finger IATLMDSLPDITLLKVSLELGLQVMRM K15(HeavyDimethyl); M25(Oxidation); Q80TB7-2 SWIM domain- 1 4040.200 2.99 TLSTLNWR M27(Oxidation) containing protein 6 Triosephosphate N-Term(Dimethyl); IAVAAQNCYK P17751 2 1193.631 2.56 isomerase C8(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Triosephosphate IAVAAQNCYK P17751 C8(Carbamidomethyl); 4 1209.719 2.59 isomerase K10(HeavyDimethyl) Dimethylaniline N-Term(Dimethyl); IAVIGAGASGLTCIK P97872 monooxygenase [N- 6 1486.870 4.17 C13(Carbamidomethyl); K15(Dimethyl) oxide-forming] 5 Dimethylaniline N-Term(Dimethyl:2H(6)13C(2)); IAVIGAGASGLTCIK P97872 monooxygenase [N- C13(Carbamidomethyl); 8 1502.956 4.73 oxide-forming] 5 K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C13(Carbamidomethyl); Dimethylaniline IAVIGAGASGLTCIKCCLEEGLEPVCFE K15(HeavyDimethyl); P97872 monooxygenase [N- 3 3281.714 3.00 R C16(Carbamidomethyl); oxide-forming] 5 C17(Carbamidomethyl); C26(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl); IAVIGQSLFGQEVYCQLR Q8R0Y6 formyltetrahydrofolate 3 2109.121 5.09 C15(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); IAVIGQSLFGQEVYCQLR Q8R0Y6 formyltetrahydrofolate 2 2117.167 4.56 C15(Carbamidomethyl) dehydrogenase T-complex protein 1 N-Term(Dimethyl); IAVYSCPFDGMITETK H3BL49 4 1887.917 2.94 subunit theta C6(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit ICALDDNVCMAFAGLTADAR Q9Z2U0 C2(Carbamidomethyl); 1 2220.033 2.43 alpha type-7 C9(Carbamidomethyl) N-Term(Dimethyl); Follistatin-related C2(Carbamidomethyl); ICANVFCGAGRECAVTEK Q62356 1 2098.017 2.41 protein 1 C7(Carbamidomethyl); C13(Carbamidomethyl); K18(Dimethyl) Peroxisomal N-Term(Dimethyl); ICDFSNASKPQTIQESTGGIVEVLHKVD P51660 multifunctional enzyme C2(Carbamidomethyl); K9(Dimethyl); 2 3997.035 4.36 SEGISPNR type 2 K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal ICDFSNASKPQTIQESTGGIVEVLHKVD C2(Carbamidomethyl); P51660 multifunctional enzyme 1 4021.160 3.72 SEGISPNR K9(HeavyDimethyl); type 2 K26(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); ICEQFEAETPTDSEATQR Q8VCI5-2 Peroxisomal biogenesis 2 2139.953 3.83 C2(Carbamidomethyl) factor 19 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); ICEQFEAETPTDSEATQR Q8VCI5-2 Peroxisomal biogenesis 1 2148.001 3.07 C2(Carbamidomethyl) factor 19 ICFYNSAFSLPLSK Q5NCJ2 Protein Rapgef6 C2(Carbamidomethyl); K14(Dimethyl) 1 1674.851 2.68 N-Term(Dimethyl); Alcohol dehydrogenase ICKHPESNFCSR P00329 C2(Carbamidomethyl); K3(Dimethyl); 1 1590.748 2.56 1 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); M3(Oxidation); Isoform 3 of E3 C9(Carbamidomethyl); ICMDSPIDCVLLECGHMVTCTK Q6ZQM0-3 ubiquitin-protein ligase 1 2727.317 2.35 C14(Carbamidomethyl); rififylin C20(Carbamidomethyl); K22(HeavyDimethyl) Peroxisomal sarcosine N-Term(Dimethyl); ICYHHGDNVDPEER Q9D826 1 1768.770 2.64 oxidase C2(Carbamidomethyl) Peroxisomal sarcosine N-Term(Dimethyl:2H(6)13C(2)); ICYHHGDNVDPEER Q9D826 1 1776.814 2.57 oxidase C2(Carbamidomethyl) Isoform 2 of Succinyl- CoA ligase [GDP- N-Term(Dimethyl); IDATQVEVNPFGETPEGQVVCFDAK Q9Z2I8-2 1 2806.368 2.49 forming] subunit beta, C21(Carbamidomethyl); K25(Dimethyl) mitochondrial K9(HeavyDimethyl); IDDAAPMDKVCLISCGFPTGYGAAVNS C11(Carbamidomethyl); E9Q4Y1 Protein Adh6a 1 3100.553 2.73 AK C15(Carbamidomethyl); K29(HeavyDimethyl) C8(Carbamidomethyl); M13(Oxidation); Isoform 2 of Dynein IDDFSESCPLLEMMTNKAMK Q91XQ0-2 M14(Oxidation); K17(Dimethyl); 1 2464.104 2.75 heavy chain 8, axonemal M19(Oxidation); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); IDFQHAHGLQELEFIQGHSETEAARQC Zinc finger protein 451 D3Z6Z4 C27(Carbamidomethyl); 1 3992.984 2.85 VDQWLK (Fragment) K33(HeavyDimethyl) N-Term(Dimethyl); K9(Dimethyl); Alcohol dehydrogenase IDGASPLDKVCLIGCGFSTGYGSAVK P00329 C11(Carbamidomethyl); 13 2756.397 6.04 1 C15(Carbamidomethyl); K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K9(HeavyDimethyl); Alcohol dehydrogenase IDGASPLDKVCLIGCGFSTGYGSAVK P00329 C11(Carbamidomethyl); 5 2780.535 5.25 1 C15(Carbamidomethyl); K26(HeavyDimethyl) N-Term(Dimethyl); K9(Dimethyl); IDGASPLDKVCLIGCGFSTGYGSAVKV Alcohol dehydrogenase C11(Carbamidomethyl); P00329 3 3082.628 4.41 AK 1 C15(Carbamidomethyl); K26(Dimethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K9(HeavyDimethyl); IDGASPLDKVCLIGCGFSTGYGSAVKV Alcohol dehydrogenase C11(Carbamidomethyl); P00329 2 3114.814 4.02 AK 1 C15(Carbamidomethyl); K26(HeavyDimethyl); K29(HeavyDimethyl) N-Term(Dimethyl); K9(Dimethyl); IDPSAPLDKVCLLGCGISTGYGAAVNT Alcohol dehydrogenase P28474 C11(Carbamidomethyl); 1 3032.583 3.63 AK class-3 C15(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K9(HeavyDimethyl); IDPSAPLDKVCLLGCGISTGYGAAVNT Alcohol dehydrogenase P28474 C11(Carbamidomethyl); 1 3056.715 3.68 AK class-3 C15(Carbamidomethyl); K29(HeavyDimethyl) Isoform 2 of Zinc finger IDSSMAHSGVSSPIRGVGGLAK Q3U288-2 N-Term(Dimethyl); K22(Dimethyl) 1 2182.195 2.66 protein 710 N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); IEAKYVEKEEDEICWISNIME D6RFV2 Protein 1700015F17Rik 1 2752.455 2.57 K8(HeavyDimethyl); C14(Carbamidomethyl); M20(Oxidation)

Mediator of RNA IEDPQIQAHWSNINDVYESSVKVLITSQ K22(Dimethyl); C34(Carbamidomethyl); Q8VCD5 polymerase II 1 4148.089 3.24 GYEQICK K35(Dimethyl) transcription subunit 17 N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein C8(Carbamidomethyl); IEGDMIVCAAYAHELPKYGVK D3YYV8 1 2472.395 2.80 L5 (Fragment) K17(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NGFI-A-binding protein K6(HeavyDimethyl); IEQAEKGMAKQMELLCAQAGYER E9PZ64 1 2762.482 2.91 1 K10(HeavyDimethyl); C16(Carbamidomethyl) Isoform 2 of Probable IESMDIDLTPPAR F6TQD1-2 E3 SUMO-protein ligase N-Term(Dimethyl); M4(Oxidation) 1 1501.761 2.13 RNF212 N-Term(Dimethyl:2H(6)13C(2)); Keratin, type II IETRDGKLVSESSDVVSK P11679 K7(HeavyDimethyl); 1 2057.268 2.32 cytoskeletal 8 K18(HeavyDimethyl) C4(Carbamidomethyl); IEVCSLLLSYGADPTLLNCHNK Q3UES3 Tankyrase-2 1 2545.272 2.80 C19(Carbamidomethyl); K22(Dimethyl) IFGGLVKLAEELPSLTHLNLNGNNLND K7(Dimethyl); K35(Dimethyl); E9Q148 Uncharacterized protein 1 3999.210 2.94 ISTLEPLKK K36(Dimethyl) IFGHRIITINFAVNDMYLFSEMERFNDL N-Term(Dimethyl:2H(6)13C(2)); V9GXL8 Protein Rgsl1 1 4694.439 3.14 VSSAHMLQINR M16(Oxidation) Follistatin-related N-Term(Dimethyl:2H(6)13C(2)); IFMSYEEICPR Q5STE3 1 1496.726 1.93 protein 4 M3(Oxidation); C9(Carbamidomethyl) Enoyl-CoA hydratase, N-Term(Dimethyl); K6(Dimethyl); IFPVEKLVEEAIQCAEK F6T930 mitochondrial 6 2087.154 3.19 C14(Carbamidomethyl); K17(Dimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); Enoyl-CoA hydratase, K6(HeavyDimethyl); IFPVEKLVEEAIQCAEK F6T930 mitochondrial 1 2111.299 2.69 C14(Carbamidomethyl); (Fragment) K17(HeavyDimethyl) MCG8382, isoform N-Term(Dimethyl); IFVGNVSAACTSQELR J3QN51 7 1779.899 3.60 CRA_d C10(Carbamidomethyl) MCG8382, isoform N-Term(Dimethyl:2H(6)13C(2)); IFVGNVSAACTSQELR J3QN51 1 1787.947 2.16 CRA_d C10(Carbamidomethyl) IGAGCFVSGLDTAHSEALHGLELHDVI Q7TMC8 L-fucose kinase C5(Carbamidomethyl) 1 3645.811 2.78 LQGHHVR Short-chain specific acyl- N-Term(Dimethyl); IGCFALSEPGNGSDAGAASTTAR Q07417 CoA dehydrogenase, 1 2238.045 4.46 C3(Carbamidomethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); IGCFALSEPGNGSDAGAASTTAR Q07417 CoA dehydrogenase, 1 2246.084 3.53 C3(Carbamidomethyl) mitochondrial Hemoglobin subunit IGGHGAEYGAEALER P01942 4 1529.737 2.56 alpha Hemoglobin subunit IGGHGAEYGAEALER P01942 N-Term(Dimethyl:2H(6)13C(2)) 1 1565.809 1.97 alpha Short-chain specific acyl- N-Term(Dimethyl); IGIASQALGIAQASLDCAVK Q07417 CoA dehydrogenase, 7 2042.140 4.38 C17(Carbamidomethyl); K20(Dimethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); IGIASQALGIAQASLDCAVK Q07417 CoA dehydrogenase, C17(Carbamidomethyl); 1 2058.222 2.74 mitochondrial K20(HeavyDimethyl)

Short-chain specific acyl- N-Term(Dimethyl); IGIASQALGIAQASLDCAVKYAENR Q07417 CoA dehydrogenase, 9 2675.418 5.25 C17(Carbamidomethyl); K20(Dimethyl) mitochondrial

Short-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); IGIASQALGIAQASLDCAVKYAENR Q07417 CoA dehydrogenase, C17(Carbamidomethyl); 7 2691.504 3.56 mitochondrial K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Short-chain specific acyl- IGIASQALGIAQASLDCAVKYAENRNA C17(Carbamidomethyl); Q07417 CoA dehydrogenase, 1 3627.082 3.26 FGAPLTK K20(HeavyDimethyl); mitochondrial K34(HeavyDimethyl) N-Term(Dimethyl); K3(Dimethyl); IGKPHTVPCKVTGR L7N240 Protein Gm6139 1 1633.957 2.88 C9(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Thioredoxin domain- K3(HeavyDimethyl); IGKVDCTQHYAVCSEHQVR E9PXX7 1 2359.219 3.56 containing protein 5 C6(Carbamidomethyl); C13(Carbamidomethyl) Isoform Peroxisomal of N-Term(Dimethyl:2H(6)13C(2)); IGLLGYNATTENVDRVAEALREALQH Serine--pyruvate O35423-2 C27(Carbamidomethyl); 1 3310.820 3.08 CPK aminotransferase, K29(HeavyDimethyl) mitochondrial N-Term(Dimethyl); IGPALSCGNTVVVKPAEQTPLTALHLA P24549 Retinal dehydrogenase 1 C7(Carbamidomethyl); K14(Dimethyl); 5 3282.889 4.79 SLIK K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); IGPALSCGNTVVVKPAEQTPLTALHLA C7(Carbamidomethyl); P24549 Retinal dehydrogenase 1 1 3307.003 3.63 SLIK K14(HeavyDimethyl); K31(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ras-related protein Rab- IGPQHAATNASHGSNQGGQQAGGGCC P53994 C25(Carbamidomethyl); 1 2558.137 2.67 2A C26(Carbamidomethyl) DNA damage-binding N-Term(Dimethyl); IGRPSETGIIGIIDPECR Q3U1J4 1 2011.070 2.57 protein 1 C17(Carbamidomethyl) N-Term(Dimethyl); IGRYNLTPTIFFCATPPDDGNLCR Q64442 Sorbitol dehydrogenase C13(Carbamidomethyl); 4 2826.367 4.78 C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); IGRYNLTPTIFFCATPPDDGNLCR Q64442 Sorbitol dehydrogenase C13(Carbamidomethyl); 13 2834.407 4.87 C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Aspartate--tRNA ligase, IGSCTQQDVELHVQK Q922B2 C4(Carbamidomethyl); 1 1814.002 2.38 cytoplasmic K15(HeavyDimethyl) Isoform 2 of E3 IGTGGQVVDCSRLFDNDLPDGWEERR A2A5Z6-2 ubiquitin-protein ligase C10(Carbamidomethyl) 1 2991.444 2.58 SMURF2 N-Term(Dimethyl); IGVDNHVLPLDCVTLQTFLAK F8VPN4 Protein Agl 1 2409.307 2.73 C12(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); IGVDNHVLPLDCVTLQTFLAK F8VPN4 Protein Agl C12(Carbamidomethyl); 2 2425.405 3.03 K21(HeavyDimethyl) Peroxisomal bifunctional N-Term(Dimethyl); IGVVVGNCYGFVGNR Q9DBM2 9 1638.838 3.77 enzyme C8(Carbamidomethyl) Peroxisomal bifunctional N-Term(Dimethyl:2H(6)13C(2)); IGVVVGNCYGFVGNR Q9DBM2 7 1646.879 3.87 enzyme C8(Carbamidomethyl) N-Term(Dimethyl); K6(Dimethyl); Structural maintenance IHEDTKEITEKSNVLSNEMK E9Q2X6 K11(Dimethyl); M19(Oxidation); 1 2473.258 2.84 of chromosomes protein K20(Dimethyl) N-Term(Dimethyl); IHEGCEEPATHNALAK Q68FD5 Clathrin heavy chain 1 2 1832.897 2.41 C5(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl); K5(Dimethyl); IHNGKESFHHEK Q2TL60 Zinc finger protein 667 2 1546.804 2.25 K12(Dimethyl) Isoform 2 of Major facilitator superfamily IHPELSSGENMILIAASSTERETHHHP Q6PDC8-2 N-Term(Dimethyl); M11(Oxidation) 1 3037.460 3.17 domain-containing protein 4 UDP- N-Term(Dimethyl:2H(6)13C(2)); IHQYFGDLCSQLLSR Q8JZZ0 glucuronosyltransferase 1 1872.988 2.54 C9(Carbamidomethyl) 3A2 N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); IHTGERPFVCKHCGKAFTYSSACYYHE K11(HeavyDimethyl); B0V2W5 Protein Zfp472 1 3569.802 3.27 R C13(Carbamidomethyl); K15(HeavyDimethyl); C23(Carbamidomethyl) Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); IIAQVLEDNLLPGAICSLVCGGADIGTT G3UYR8 semialdehyde C16(Carbamidomethyl); 2 3264.725 4.17 MAR dehydrogenase C20(Carbamidomethyl) Succinyl-CoA ligase N-Term(Dimethyl:2H(6)13C(2)); [ADP/GDP-forming] IICQGFTGK Q9WUM5 C3(Carbamidomethyl); 2 1095.677 2.39 subunit alpha, K9(HeavyDimethyl) mitochondrial Succinyl-CoA ligase N-Term(Dimethyl); [ADP/GDP-forming] IICQGFTGKQGTFHSQQALEYGTK Q9WUM5 C3(Carbamidomethyl); K9(Dimethyl); 5 2783.406 3.71 subunit alpha, K24(Dimethyl) mitochondrial Succinyl-CoA ligase N-Term(Dimethyl:2H(6)13C(2)); [ADP/GDP-forming] C3(Carbamidomethyl); IICQGFTGKQGTFHSQQALEYGTK Q9WUM5 6 2807.534 5.22 subunit alpha, K9(HeavyDimethyl); mitochondrial K24(HeavyDimethyl) N-Term(Dimethyl); IICRWDTVSNQVQR Q64374 Regucalcin 5 1802.924 3.54 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); IICRWDTVSNQVQR Q64374 Regucalcin 6 1810.975 3.57 C3(Carbamidomethyl) Cytochrome b-c1 N-Term(Dimethyl); K11(Dimethyl); IIENLHDVAYKNALANPLYCPDYR Q9DB77 complex subunit 2, 10 2918.491 4.50 C20(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); IIENLHDVAYKNALANPLYCPDYR Q9DB77 complex subunit 2, K11(HeavyDimethyl); 3 2934.572 5.04 mitochondrial C20(Carbamidomethyl) Histidine triad N-Term(Dimethyl:2H(6)13C(2)); IIFEDDRCLAFHDISPQAPTHFLVIPK B0R1E3 nucleotide-binding C8(Carbamidomethyl); 1 3251.790 3.35 protein 1 K27(HeavyDimethyl) Asparagine--tRNA N-Term(Dimethyl); K4(Dimethyl); IIIKNDPSLPEPACVK Q8BP47 2 1878.076 2.66 ligase, cytoplasmic C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Asparagine--tRNA K4(HeavyDimethyl); IIIKNDPSLPEPACVK Q8BP47 1 1902.209 2.67 ligase, cytoplasmic C14(Carbamidomethyl); K16(HeavyDimethyl) Isochorismatase domain- N-Term(Dimethyl); K3(Dimethyl); IIKEPVPDSGLLSLFQGQSPLTSC P85094 containing protein 2A, 8 2642.421 4.96 C24(Carbamidomethyl) mitochondrial

Isochorismatase domain- N-Term(Dimethyl:2H(6)13C(2)); IIKEPVPDSGLLSLFQGQSPLTSC P85094 containing protein 2A, K3(HeavyDimethyl); 5 2658.507 4.55 mitochondrial C24(Carbamidomethyl) Glutamate N-Term(Dimethyl); K3(Dimethyl); IIKPCNHVLSLSFPIR P26443 dehydrogenase 1, 3 1950.136 3.39 C5(Carbamidomethyl) mitochondrial Glutamate N-Term(Dimethyl:2H(6)13C(2)); IIKPCNHVLSLSFPIR P26443 dehydrogenase 1, K3(HeavyDimethyl); 2 1966.223 3.24 mitochondrial C5(Carbamidomethyl) Glutamate IIKPCNHVLSLSFPIRRDDGSWEVIEGY N-Term(Dimethyl); K3(Dimethyl); P26443 dehydrogenase 1, 1 3512.858 3.10 R C5(Carbamidomethyl) mitochondrial Glutamate N-Term(Dimethyl:2H(6)13C(2)); IIKPCNHVLSLSFPIRRDDGSWEVIEGY P26443 dehydrogenase 1, K3(HeavyDimethyl); 1 3528.934 3.31 R mitochondrial C5(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl); IIPGFMCQGGDFTR P17742 9 1626.775 4.11 isomerase A C7(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl); M6(Oxidation); IIPGFMCQGGDFTR P17742 1 1642.767 2.52 isomerase A C7(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl:2H(6)13C(2)); IIPGFMCQGGDFTR P17742 9 1634.819 3.98 isomerase A C7(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl:2H(6)13C(2)); IIPGFMCQGGDFTR P17742 5 1650.812 2.85 isomerase A M6(Oxidation); C7(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl); IIPGFMCQGGDFTRHNGTGGR P17742 11 2306.093 3.49 isomerase A C7(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl:2H(6)13C(2)); IIPGFMCQGGDFTRHNGTGGR P17742 6 2314.134 3.16 isomerase A C7(Carbamidomethyl) N-Term(Dimethyl); IIQALNECLDALPR D6RJM2 Sedoheptulokinase 3 1653.895 3.67 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); IIQALNECLDALPR D6RJM2 Sedoheptulokinase 1 1661.946 2.61 C8(Carbamidomethyl) N-Term(Dimethyl); K10(Dimethyl); IIQLLDDYPKCFIVGADNVGSK E9Q070 Uncharacterized protein 1 2549.368 3.01 C11(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K10(HeavyDimethyl); IIQLLDDYPKCFIVGADNVGSK E9Q070 Uncharacterized protein 2 2573.489 3.37 C11(Carbamidomethyl); K22(HeavyDimethyl) Sodium/potassium- N-Term(Dimethyl); IISANGCKVDNSSLTGESEPQTR Q8VDN2 transporting ATPase 4 2519.230 4.23 C7(Carbamidomethyl); K8(Dimethyl) subunit alpha-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); IISANGCKVDNSSLTGESEPQTR Q8VDN2 transporting ATPase C7(Carbamidomethyl); 1 2535.322 2.94 subunit alpha-1 K8(HeavyDimethyl) Sodium/potassium- IISANGCKVDNSSLTGESEPQTRSPDFT N-Term(Dimethyl); Q8VDN2 transporting ATPase 2 4019.904 5.04 NENPLETR C7(Carbamidomethyl); K8(Dimethyl) subunit alpha-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); IISANGCKVDNSSLTGESEPQTRSPDFT Q8VDN2 transporting ATPase C7(Carbamidomethyl); 1 4036.013 3.54 NENPLETR subunit alpha-1 K8(HeavyDimethyl) Serine/threonine-protein IISNLDCVNEVIGIRQLSQSLLPAIVELA phosphatase 2A 65 kDa C7(Carbamidomethyl); H3BK50 1 3999.224 3.09 EDAKWR regulatory subunit A K33(HeavyDimethyl) beta isoform (Fragment)

Triosephosphate N-Term(Dimethyl); IIYGGSVTGATCK P17751 2 1382.730 2.85 isomerase C12(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Triosephosphate IIYGGSVTGATCK P17751 C12(Carbamidomethyl); 2 1398.820 2.50 isomerase K13(HeavyDimethyl) N-Term(Dimethyl); IIYGGSVTGATCKELASQPDVDGFLVG Triosephosphate P17751 C12(Carbamidomethyl); K13(Dimethyl); 4 4577.432 5.81 GASLKPEFVDIINAKQ isomerase K32(Dimethyl); K42(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C12(Carbamidomethyl); IIYGGSVTGATCKELASQPDVDGFLVG Triosephosphate P17751 K13(HeavyDimethyl); 3 4609.607 5.08 GASLKPEFVDIINAKQ isomerase K32(HeavyDimethyl); K42(HeavyDimethyl) Alcohol dehydrogenase N-Term(Dimethyl); K2(Dimethyl); IKMVATGVCR P00329 5 1190.671 3.60 1 C9(Carbamidomethyl) Alcohol dehydrogenase N-Term(Dimethyl); K2(Dimethyl); IKMVATGVCR P00329 3 1206.666 3.02 1 M3(Oxidation); C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase IKMVATGVCR P00329 K2(HeavyDimethyl); 2 1206.765 3.09 1 C9(Carbamidomethyl) Acyl-coenzyme A IKPTRPLGLFMEYENSPESTSEVECGDF synthetase ACSM1, N-Term(Dimethyl); K2(Dimethyl); D3Z106 1 3980.828 3.74 YNSGDR mitochondrial C25(Carbamidomethyl) (Fragment) IKTEFLVQMQGVGVDNDGILVLGATNI Vacuolar protein sorting- N-Term(Dimethyl); K2(Dimethyl); P46467 1 3954.103 3.17 PWVLDSAIR associated protein 4B M9(Oxidation)

Succinyl-CoA ligase N-Term(Dimethyl); ILACDDLDEAAK Q9Z2I9 [ADP-forming] subunit 1 1389.689 2.24 C4(Carbamidomethyl); K12(Dimethyl) beta, mitochondrial

Succinyl-CoA ligase N-Term(Dimethyl:2H(6)13C(2)); ILACDDLDEAAK Q9Z2I9 [ADP-forming] subunit C4(Carbamidomethyl); 2 1405.781 1.93 beta, mitochondrial K12(HeavyDimethyl)

Phenylalanine-4- N-Term(Dimethyl); ILADSINSEVGILCHALQK P16331 7 2137.176 5.00 hydroxylase C14(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine-4- ILADSINSEVGILCHALQK P16331 C14(Carbamidomethyl); 6 2153.265 3.75 hydroxylase K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine-4- C14(Carbamidomethyl); ILADSINSEVGILCHALQKIK P16331 1 2430.518 2.89 hydroxylase K19(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl); Phenylalanine-4- ILADSINSEVGILCHALQKIKS P16331 C14(Carbamidomethyl); K19(Dimethyl); 2 2493.419 3.74 hydroxylase K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine-4- C14(Carbamidomethyl); ILADSINSEVGILCHALQKIKS P16331 3 2517.552 3.55 hydroxylase K19(HeavyDimethyl); K21(HeavyDimethyl) ILAERVLILEHMIGVHDPLASPEGGSGQ Isoform 2 of Collagen Q91VF6-2 M12(Oxidation); K37(HeavyDimethyl) 1 3943.189 2.67 DAALRANLK alpha-1(XXVI) chain K10(HeavyDimethyl); ILAILWFDAKTISLPECFAQIYAIHTFMS Q8VG18 MCG1046646 C17(Carbamidomethyl); 1 4961.489 3.55 MESGVFLCMAIDR M28(Oxidation); C37(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILALCMGNHELYMR Q7TSG6 Radixin 1 1756.907 2.15 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILATAVCHTDAYTLSGADPEGCFPVIL Alcohol dehydrogenase C7(Carbamidomethyl); P28474 1 4570.338 3.67 GHEGAGIVESVGEGVTK class-3 C22(Carbamidomethyl); K44(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); ILATAVCHTDAYTLSGADPEGCFPVIL Alcohol dehydrogenase P28474 C22(Carbamidomethyl); 1 4847.630 3.45 GHEGAGIVESVGEGVTKLK class-3 K44(HeavyDimethyl); K46(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ILCEELGAPANSAVNCVPLEDFGGHHP C3(Carbamidomethyl); Q9D0F9 Phosphoglucomutase-1 1 4637.286 3.49 DPNLTYAADLVETMK C16(Carbamidomethyl); K42(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Lon protease homolog, ILCFHGPPGVGK Q8CGK3 C3(Carbamidomethyl); 1 1353.831 2.36 mitochondrial K12(HeavyDimethyl) Aldehyde N-Term(Dimethyl); ILCGEGVDQLSLPLR Q8BH00 dehydrogenase family 8 3 1697.923 3.72 C3(Carbamidomethyl) member A1 Aldehyde N-Term(Dimethyl:2H(6)13C(2)); ILCGEGVDQLSLPLR Q8BH00 dehydrogenase family 8 3 1705.970 3.37 C3(Carbamidomethyl) member A1 Aldehyde ILCGEGVDQLSLPLRNQAGYFMLPTVI N-Term(Dimethyl); Q8BH00 dehydrogenase family 8 1 4005.092 3.73 TDIKDESR C3(Carbamidomethyl); K31(Dimethyl) member A1 Aldehyde N-Term(Dimethyl:2H(6)13C(2)); ILCGEGVDQLSLPLRNQAGYFMLPTVI Q8BH00 dehydrogenase family 8 C3(Carbamidomethyl); 2 4021.186 3.91 TDIKDESR member A1 K31(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); ILDIYHQEACNGCIISVGGQIPNNLAVP Q8C196 synthase [ammonia], C10(Carbamidomethyl); 7 3525.854 4.66 LYK mitochondrial C13(Carbamidomethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate ILDIYHQEACNGCIISVGGQIPNNLAVP C10(Carbamidomethyl); Q8C196 synthase [ammonia], 6 3541.910 6.24 LYK C13(Carbamidomethyl); mitochondrial K31(HeavyDimethyl) N-Term(Dimethyl); Carbamoyl-phosphate ILDIYHQEACNGCIISVGGQIPNNLAVP C10(Carbamidomethyl); Q8C196 synthase [ammonia], 2 3952.090 5.09 LYKNGVK C13(Carbamidomethyl); K31(Dimethyl); mitochondrial K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate C10(Carbamidomethyl); ILDIYHQEACNGCIISVGGQIPNNLAVP Q8C196 synthase [ammonia], C13(Carbamidomethyl); 2 3976.183 4.05 LYKNGVK mitochondrial K31(HeavyDimethyl); K35(HeavyDimethyl) Histidine triad ILDRSLPADILYEDQQCLVFRDVAPQA N-Term(Dimethyl); Q9D0S9 nucleotide-binding 2 4232.243 3.90 PVHFLVIPR C17(Carbamidomethyl) protein 2, mitochondrial

Histidine triad ILDRSLPADILYEDQQCLVFRDVAPQA N-Term(Dimethyl:2H(6)13C(2)); Q9D0S9 nucleotide-binding 1 4240.319 3.38 PVHFLVIPR C17(Carbamidomethyl) protein 2, mitochondrial

N-Term(Dimethyl); ILEDLNAWSEAQNFANSVACGSASPAE Isoform 2 of Q63880-2 C20(Carbamidomethyl); 7 3889.892 5.05 LVQCLLQK Carboxylesterase 3A C31(Carbamidomethyl); K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ILEDLNAWSEAQNFANSVACGSASPAE Isoform 2 of C20(Carbamidomethyl); Q63880-2 7 3906.031 4.69 LVQCLLQK Carboxylesterase 3A C31(Carbamidomethyl); K35(HeavyDimethyl) N-Term(Dimethyl); ILEDLNAWSEAQNFANSVACGSASPAE Isoform 2 of C20(Carbamidomethyl); Q63880-2 1 4232.135 3.91 LVQCLLQKEGK Carboxylesterase 3A C31(Carbamidomethyl); K35(Dimethyl); K38(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C20(Carbamidomethyl); ILEDLNAWSEAQNFANSVACGSASPAE Isoform 2 of Q63880-2 C31(Carbamidomethyl); 1 4256.254 3.88 LVQCLLQKEGK Carboxylesterase 3A K35(HeavyDimethyl); K38(HeavyDimethyl) Fibrous sheath- M7(Oxidation); M10(Oxidation); ILEEHEMEIMPNKDFLNDTK A2ARZ3 1 2534.242 2.44 interacting protein 2 K13(Dimethyl); K20(Dimethyl) Protein disulfide- N-Term(Dimethyl); K8(Dimethyl); ILEFFGLKKEECPAVR P09103 1 2020.132 2.69 isomerase K9(Dimethyl); C12(Carbamidomethyl) Copper homeostasis N-Term(Dimethyl); ILEGSGATEFHCSAR D3YY50 protein cutC homolog 4 1662.784 2.91 C12(Carbamidomethyl) (Fragment) Copper homeostasis N-Term(Dimethyl:2H(6)13C(2)); ILEGSGATEFHCSAR D3YY50 protein cutC homolog 3 1670.834 3.22 C12(Carbamidomethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Armadillo K5(HeavyDimethyl); ILETKELNDLHVEALSVIANCLEDMDT A2AU72-2 repeat-containing protein C21(Carbamidomethyl); 1 4574.526 3.35 MVLMQQTGSLKK 3 K38(HeavyDimethyl); K39(HeavyDimethyl) Protein Cped1 N-Term(Dimethyl:2H(6)13C(2)); ILFIGDSTNRGMMYYLIER E9Q7L8 1 2344.232 2.30 (Fragment) M12(Oxidation) Isoform 3 of ILHRHELDTFLAQAVSTQLYEPDQLQE Constitutive coactivator Q8C3F2-3 K29(HeavyDimethyl) 1 3471.852 2.73 LK of PPAR-gamma-like protein 2 N-Term(Dimethyl); Carbonyl reductase ILLNACCPGWVK Q8K354 C6(Carbamidomethyl); 2 1486.770 2.83 [NADPH] 3 C7(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); Carbonyl reductase ILLNACCPGWVR P48758 C6(Carbamidomethyl); 9 1486.765 2.97 [NADPH] 1 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbonyl reductase ILLNACCPGWVR P48758 C6(Carbamidomethyl); 6 1494.812 3.00 [NADPH] 1 C7(Carbamidomethyl) Isochorismatase domain- N-Term(Dimethyl); ILPESSILFLCDLQEK P85094 containing protein 2A, 7 1961.072 3.88 C11(Carbamidomethyl); K16(Dimethyl) mitochondrial Isochorismatase domain- N-Term(Dimethyl:2H(6)13C(2)); ILPESSILFLCDLQEK P85094 containing protein 2A, C11(Carbamidomethyl); 5 1977.157 3.32 mitochondrial K16(HeavyDimethyl)

Isochorismatase domain- ILPESSILFLCDLQEKFRPSIAYFPQIVSV N-Term(Dimethyl); P85094 containing protein 2A, 3 3864.109 3.67 AAR C11(Carbamidomethyl); K16(Dimethyl) mitochondrial

Isochorismatase domain- N-Term(Dimethyl:2H(6)13C(2)); ILPESSILFLCDLQEKFRPSIAYFPQIVSV P85094 containing protein 2A, C11(Carbamidomethyl); 1 3880.213 4.00 AAR mitochondrial K16(HeavyDimethyl) ILQACGGHSLGAYSISSGIQPIREDVAQ Alanine N-Term(Dimethyl:2H(6)13C(2)); Q8QZR5 1 3524.822 3.36 YIER aminotransferase 1 C5(Carbamidomethyl) ILQACGGHSLGAYSISSGIQPIREDVAQ Alanine N-Term(Dimethyl); Q8QZR5 2 3672.893 3.37 YIERR aminotransferase 1 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine ILQACGGNSLGSYSASQGVNCIR Q8BGT5 C5(Carbamidomethyl); 1 2448.212 4.47 aminotransferase 2 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILQANGHSFVHMEHEKAVLLLKSFQN Leucine-rich repeat- Q80TE7 M12(Oxidation); K16(HeavyDimethyl); 1 4039.384 3.04 TVDLVIQR containing protein 7 K22(HeavyDimethyl) ILQFRLASADGEHWIDVSLVPAFDVLG 2'-5'-oligoadenylate Q8VI93 1 3349.726 2.96 QPR synthase 3 Acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); ILQIMCDRAVQR D3YTQ5 dehydrogenase family 1 1538.871 1.88 C6(Carbamidomethyl) member 11 N-Term(Dimethyl); K8(Dimethyl); ILQSTAGKYCVGDEVSMADVCLVPQV Maleylacetoacetate Q9WVL0 C10(Carbamidomethyl); 2 3436.685 4.30 ANAER isomerase C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILQSTAGKYCVGDEVSMADVCLVPQV Maleylacetoacetate K8(HeavyDimethyl); Q9WVL0 2 3452.794 3.61 ANAER isomerase C10(Carbamidomethyl); C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILQSTAGKYCVGDEVSMADVCLVPQV Maleylacetoacetate K8(HeavyDimethyl); Q9WVL0 1 3468.789 3.73 ANAER isomerase C10(Carbamidomethyl); M17(Oxidation); C21(Carbamidomethyl) Delta-1-pyrroline-5- ILREAGLPPNIIQFVPADGPTFGDTVTSS carboxylate N-Term(Dimethyl); Q8CHT0 1 4856.493 3.25 EHLCGINFTGSVPTFK dehydrogenase, C33(Carbamidomethyl); K45(Dimethyl) mitochondrial Delta-1-pyrroline-5- N-Term(Dimethyl:2H(6)13C(2)); ILREAGLPPNIIQFVPADGPTFGDTVTSS carboxylate Q8CHT0 C33(Carbamidomethyl); 2 4872.613 3.35 EHLCGINFTGSVPTFK dehydrogenase, K45(HeavyDimethyl) mitochondrial N-Term(Dimethyl); ILRGENHCGIESEIVAGIPR P10605 Cathepsin B 1 2248.182 3.07 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ILRGENHCGIESEIVAGIPR P10605 Cathepsin B 3 2256.233 3.56 C8(Carbamidomethyl) C6(Carbamidomethyl); Serine/threonine-protein ILRQACKLMAEEAK E9Q341 K7(HeavyDimethyl); 1 1733.030 2.25 kinase 36 (Fragment) K14(HeavyDimethyl) Isoform 2 of Solute N-Term(Dimethyl:2H(6)13C(2)); ILSQQGWPGLYRGMTPTLLKVLPAGGI Q8BVN7-2 carrier family 25 K20(HeavyDimethyl); 1 4059.313 3.58 SYLVYEAMK member 41 K36(HeavyDimethyl) Alpha-aminoadipic N-Term(Dimethyl); ILVEGIGEVQEYVDVCDYAAGLSR G3UYR8 semialdehyde 1 2683.307 3.33 C16(Carbamidomethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); ILVEGIGEVQEYVDVCDYAAGLSR G3UYR8 semialdehyde 1 2691.359 3.27 C16(Carbamidomethyl) dehydrogenase L-serine dehydratase/L- N-Term(Dimethyl:2H(6)13C(2)); ILVEPACGAALAAVYSR Q8VBT2 1 1797.017 2.26 threonine deaminase C7(Carbamidomethyl) Myosin light polypeptide N-Term(Dimethyl); ILYSQCGDVMR Q60605 2 1369.660 2.32 6 C6(Carbamidomethyl) IMLNMFLDTMMADPPPQCLVWLPLM M11(Oxidation); G3UXI3 Dystrobrevin beta 2 3302.581 2.92 HR C18(Carbamidomethyl); M25(Oxidation) UPF0586 protein M2(Oxidation); M9(Oxidation); IMPASTFDMDKLK Q80UY1 2 1584.804 2.24 C9orf41 homolog K11(Dimethyl); K13(Dimethyl) N-Term(Dimethyl); IMQNFSFQPCK Q64459 Cytochrome P450 3A11 2 1455.710 2.33 C10(Carbamidomethyl); K11(Dimethyl)

IMSVLDEAIHKIELITLMSYMESHPEAL Isoform 2 of IQ domain- N-Term(Dimethyl:2H(6)13C(2)); Q9D3V1-2 1 4843.574 3.18 EDTLPEDFVRALR containing protein D M2(Oxidation); K11(HeavyDimethyl) T-complex protein 1 N-Term(Dimethyl); INALTAASEAACLIVSVDETIKNPR P80313 2 2712.477 5.95 subunit eta C12(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 INALTAASEAACLIVSVDETIKNPR P80313 C12(Carbamidomethyl); 4 2728.565 4.72 subunit eta K22(HeavyDimethyl) UDP-glucose 6- N-Term(Dimethyl); K17(Dimethyl); INAWNSPTLPIYEPGLKEVVESCR O70475 1 2828.463 2.69 dehydrogenase C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); UDP-glucose 6- INAWNSPTLPIYEPGLKEVVESCR O70475 K17(HeavyDimethyl); 2 2844.554 3.14 dehydrogenase C23(Carbamidomethyl) INCVAPGTIYSQTAVDNYGEMGQTLFE Peroxisomal trans-2- N-Term(Dimethyl); Q3UXD9 1 4150.974 3.73 MAFDSIPAKR enoyl-CoA reductase C3(Carbamidomethyl); K36(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); INCVAPGTIYSQTAVDNYGEMGQTLFE Peroxisomal trans-2- Q3UXD9 C3(Carbamidomethyl); 1 4167.093 3.91 MAFDSIPAKR enoyl-CoA reductase K36(HeavyDimethyl) INESIGQGDLSELPELHALTAGLKAFTT Acyl-coenzyme A N-Term(Dimethyl); K24(Dimethyl); A2A848 2 4269.144 4.02 WTANAGIEECR oxidase (Fragment) C38(Carbamidomethyl) N-Term(Dimethyl); INGCAIQCR G5E8R3 Pyruvate carboxylase C4(Carbamidomethyl); 1 1119.535 2.20 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); INGCAIQCR G5E8R3 Pyruvate carboxylase C4(Carbamidomethyl); 1 1127.581 2.05 C8(Carbamidomethyl) Poly(rC)-binding protein N-Term(Dimethyl:2H(6)13C(2)); INISEGNCPER P60335 1 1324.663 1.96 1 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); INMAHLCIVGCHAVNGVAK Q3UEJ6 Phosphorylase 1 2136.185 2.86 C11(Carbamidomethyl); K19(HeavyDimethyl) Aspartate N-Term(Dimethyl); INMCGLTTKNLDYVATSIHEAVTKIQ P05201 aminotransferase, C4(Carbamidomethyl); K9(Dimethyl); 1 3004.594 3.12 cytoplasmic K24(Dimethyl) UDP- IPAPISYVPAALSELTDQMSFGERVKNI N-Term(Dimethyl); K26(Dimethyl); Q6PDD0 glucuronosyltransferase 1 4488.385 2.87 ISYSLQDYIFK K39(Dimethyl) 2A2 Sulfotransferase 1A1 N-Term(Dimethyl); IPFLEFSCPGVPPGLETLK D3Z2P8 2 2157.169 2.91 (Fragment) C8(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sulfotransferase 1A1 IPFLEFSCPGVPPGLETLK D3Z2P8 C8(Carbamidomethyl); 1 2173.258 2.33 (Fragment) K19(HeavyDimethyl) Sulfotransferase 1A1 N-Term(Dimethyl); IPFLEFSCPGVPPGLETLKETPAPR D3Z2P8 1 2808.506 2.64 (Fragment) C8(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sulfotransferase 1A1 IPFLEFSCPGVPPGLETLKETPAPR D3Z2P8 C8(Carbamidomethyl); 1 2824.585 2.93 (Fragment) K19(HeavyDimethyl) N-Term(Dimethyl); M3(Oxidation); IPMEGIPSDPQNGIHCVARK D3YVG0 Protein Slc4a5 1 2291.156 2.48 C16(Carbamidomethyl); K20(Dimethyl) C10(Carbamidomethyl); IPMPQAGVFCNGAAQPGTFQARDNISN F2Z4A6 GAS2-like protein 2 C32(Carbamidomethyl); 1 3915.885 2.79 FIQWCRK K34(HeavyDimethyl) Elongator complex IPRLNNLTCDESDVK A2A414 C9(Carbamidomethyl); K15(Dimethyl) 1 1801.889 2.40 protein 4 (Fragment) IPTIALLPDDLEDSPPSLPQHTYWEEQG D3Z1D3 Protein 3425401B19Rik N-Term(Dimethyl); K30(Dimethyl) 1 4358.233 3.39 FKGHFLSAPR Isoform 2 of Methionine K10(Dimethyl); M19(Oxidation); IPVLYGEVEKLEESAVTVMFDK Q99LB6-2 adenosyltransferase 2 1 2568.346 2.35 K22(Dimethyl) subunit beta N-Term(Dimethyl); IQCAKTLILSLQQLFNEMIQENGYNFD O35638 Cohesin subunit SA-2 C3(Carbamidomethyl); K5(Dimethyl); 1 3458.736 2.96 R M18(Oxidation) N-Term(Dimethyl); IQEEAGCLIK P56593 Cytochrome P450 2A12 1 1216.657 2.09 C7(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); IQEEAGCLIK P56593 Cytochrome P450 2A12 C7(Carbamidomethyl); 2 1232.751 2.06 K10(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); IQEEAQCLVEELR P12791-2 1 1644.829 2.34 Cytochrome P450 2B10 C7(Carbamidomethyl)

Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); IQEEAQCLVEELR P12791-2 3 1652.867 2.29 Cytochrome P450 2B10 C7(Carbamidomethyl)

K10(HeavyDimethyl); IQEGAAVLQKMLLEDELQDAVLLLFA ADP-ribosylation factor F6UFB9 K28(HeavyDimethyl); M35(Oxidation); 1 4897.733 3.03 NKQDLPNAMAISEMTDK 4 (Fragment) M40(Oxidation); K43(HeavyDimethyl) Protein NipSnap N-Term(Dimethyl); K7(Dimethyl); IQFHNVKPECLDAYNSLTEAVLPK Q5SVG6 7 2870.526 4.26 homolog 1 (Fragment) C10(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein NipSnap K7(HeavyDimethyl); IQFHNVKPECLDAYNSLTEAVLPK Q5SVG6 3 2894.636 4.19 homolog 1 (Fragment) C10(Carbamidomethyl); K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- IQLAMVCYSPDFEK D3YX76 C7(Carbamidomethyl); 1 1772.952 2.88 transferase Mu 2 K14(HeavyDimethyl) N-Term(Dimethyl); Alcohol dehydrogenase IQVIATCVCPTDINATDPK Q9QYY9 C7(Carbamidomethyl); 1 2172.103 3.87 4 C9(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase C7(Carbamidomethyl); IQVIATCVCPTDINATDPK Q9QYY9 1 2188.189 4.91 4 C9(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl); Alcohol dehydrogenase C7(Carbamidomethyl); IQVIATCVCPTDINATDPKKK Q9QYY9 2 2484.357 2.98 4 C9(Carbamidomethyl); K19(Dimethyl); K20(Dimethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); Alcohol dehydrogenase C9(Carbamidomethyl); IQVIATCVCPTDINATDPKKK Q9QYY9 2 2516.568 4.41 4 K19(HeavyDimethyl); K20(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); IQVPNCDEIFYAGTGNLLLR Q8CIE6 Coatomer subunit alpha 1 2329.255 2.65 C6(Carbamidomethyl) GRAM domain- N-Term(Dimethyl); K17(Dimethyl); IQWSIVPEVSEAVEPAKEDLTVSEK D3YUE7 1 2867.501 2.71 containing protein 4 K25(Dimethyl) Inner nuclear membrane N-Term(Dimethyl); M9(Oxidation); IRNMFDPVMEIGDHWHLAIQEAILEK E9QP59 1 3177.580 2.71 protein Man1 K26(Dimethyl) C3(Carbamidomethyl); ISCGNVKINAVYGLLVALVVCAFDIFCI K7(HeavyDimethyl); Q7TRP4 Olfactory receptor 1 4229.285 3.42 TVSYTMILR C21(Carbamidomethyl); C27(Carbamidomethyl) Collagen alpha-1(XII) C10(Carbamidomethyl); ISFELTQSICLRIEQELAAIK E9PX70 1 2498.427 2.43 chain K21(HeavyDimethyl) Protein transport protein N-Term(Dimethyl); ISGAIGPCVSLNSK E9Q1S3 2 1458.796 2.39 Sec23A C8(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein transport protein ISGAIGPCVSLNSK E9Q1S3 C8(Carbamidomethyl); 1 1474.893 2.04 Sec23A K14(HeavyDimethyl) Betaine--homocysteine S-N-Term(Dimethyl); K5(Dimethyl); ISGQKVNEAACDIAR O35490 23 1687.873 4.82 methyltransferase 1 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- ISGQKVNEAACDIAR O35490 K5(HeavyDimethyl); 20 1703.961 4.65 methyltransferase 1 C11(Carbamidomethyl) ISIEDLLQSSMGSTQQAQNTTSSLMNL Isoform 2 of DNA Q6ZPV2-2 N-Term(Dimethyl:2H(6)13C(2)) 1 3594.774 2.74 VMQFR helicase INO80 60S ribosomal protein N-Term(Dimethyl); ISLGLPVGAVINCADNTGAK A2A6F8 11 2026.098 4.91 L23 (Fragment) C13(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein ISLGLPVGAVINCADNTGAK A2A6F8 C13(Carbamidomethyl); 9 2042.190 4.10 L23 (Fragment) K20(HeavyDimethyl) N-Term(Dimethyl); 60S ribosomal protein ISLGLPVGAVINCADNTGAKNLYIISVK P62830 C13(Carbamidomethyl); K20(Dimethyl); 1 2984.695 3.00 L23 K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein C13(Carbamidomethyl); ISLGLPVGAVINCADNTGAKNLYIISVK A2A6F8 1 3008.830 2.99 L23 (Fragment) K20(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl); ISSCMEVLDLFLNQPHAVLSSFVLAEK P19096 Fatty acid synthase C4(Carbamidomethyl); K27(Dimethyl); 2 3259.747 4.27 K K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ISSCMEVLDLFLNQPHAVLSSFVLAEK C4(Carbamidomethyl); P19096 Fatty acid synthase 3 3283.900 4.87 K K27(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl); ISSEYSDMIESFCK Q8R084 Protein Ugt2b1 6 1751.779 3.76 C13(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl); M8(Oxidation); ISSEYSDMIESFCK Q8R084 Protein Ugt2b1 1 1767.773 2.33 C13(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ISSEYSDMIESFCK Q8R084 Protein Ugt2b1 C13(Carbamidomethyl); 3 1767.880 3.62 K14(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); ISSEYSDMIESFCK Q8R084 Protein Ugt2b1 M8(Oxidation); C13(Carbamidomethyl); 2 1783.863 2.69 K14(HeavyDimethyl) ISSINSISALCEATGADVEEVATAIGMD UDP-glucose 6- N-Term(Dimethyl); O70475 5 3136.533 6.13 QR dehydrogenase C11(Carbamidomethyl) ISSINSISALCEATGADVEEVATAIGMD UDP-glucose 6- N-Term(Dimethyl); O70475 1 3152.518 2.87 QR dehydrogenase C11(Carbamidomethyl); M27(Oxidation) ISSINSISALCEATGADVEEVATAIGMD UDP-glucose 6- N-Term(Dimethyl:2H(6)13C(2)); O70475 5 3144.565 6.22 QR dehydrogenase C11(Carbamidomethyl) ISSINSISALCEATGADVEEVATAIGMD UDP-glucose 6- N-Term(Dimethyl:2H(6)13C(2)); O70475 4 3160.563 3.26 QR dehydrogenase C11(Carbamidomethyl); M27(Oxidation)

Isoform 4 of Disintegrin N-Term(Dimethyl:2H(6)13C(2)); ISSPDVETDAEDHMAYLITINETPHFIH and metalloproteinase Q3TTE0-4 M14(Oxidation); K30(HeavyDimethyl); 1 3689.004 2.69 LKK domain-containing K31(HeavyDimethyl) protein 5 40S ribosomal protein N-Term(Dimethyl); ITAFVPNDGCLNFIEENDEVLVAGFGR P62267 4 3024.489 4.07 S23 C10(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); ITAFVPNDGCLNFIEENDEVLVAGFGR P62267 1 3032.519 2.43 S23 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ITAFVPNDGCLNFIEENDEVLVAGFGR 40S ribosomal protein P62267 C10(Carbamidomethyl); 1 3196.702 2.77 K S23 K28(HeavyDimethyl) Proteasome subunit N-Term(Dimethyl); ITESIGCVMTGMTADSR E0CXB1 5 1856.851 3.44 alpha type-6 C7(Carbamidomethyl) Proteasome subunit N-Term(Dimethyl:2H(6)13C(2)); ITESIGCVMTGMTADSR E0CXB1 1 1864.903 3.66 alpha type-6 C7(Carbamidomethyl) N-Term(Dimethyl); ITGTNAEVMPAQWEFQIGPCEGIR P15105 Glutamine synthetase 12 2732.318 5.51 C20(Carbamidomethyl) N-Term(Dimethyl); M9(Oxidation); ITGTNAEVMPAQWEFQIGPCEGIR P15105 Glutamine synthetase 1 2748.316 4.71 C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ITGTNAEVMPAQWEFQIGPCEGIR P15105 Glutamine synthetase 6 2740.363 4.98 C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); ITGTNAEVMPAQWEFQIGPCEGIR P15105 Glutamine synthetase 1 2756.361 2.59 M9(Oxidation); C20(Carbamidomethyl) Tyrosine-protein kinase ITMNRELGQGSFGMVYEGVAK E9QNX9 K21(HeavyDimethyl) 4 2323.180 2.76 receptor Microsomal glutathione N-Term(Dimethyl); K4(Dimethyl); ITNKVFANPEDCAGFGK D3YU60 18 1951.992 4.99 S-transferase 1 C12(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Microsomal glutathione K4(HeavyDimethyl); ITNKVFANPEDCAGFGK D3YU60 16 1976.129 5.47 S-transferase 1 C12(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl); K4(Dimethyl); Microsomal glutathione ITNKVFANPEDCAGFGKGENAK D3YU60 C12(Carbamidomethyl); K17(Dimethyl); 21 2479.255 6.52 S-transferase 1 K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); Microsomal glutathione ITNKVFANPEDCAGFGKGENAK D3YU60 C12(Carbamidomethyl); 20 2511.427 7.32 S-transferase 1 K17(HeavyDimethyl); K22(HeavyDimethyl) 3-hydroxyisobutyryl- N-Term(Dimethyl:2H(6)13C(2)); ITQACMEGHDFHEGVR Q8QZS1 CoA hydrolase, 6 1922.893 4.46 C5(Carbamidomethyl) mitochondrial Aldehyde N-Term(Dimethyl); ITQLSAPHCK Q8BH00 dehydrogenase family 8 3 1210.658 2.77 C9(Carbamidomethyl); K10(Dimethyl) member A1 Aldehyde N-Term(Dimethyl:2H(6)13C(2)); ITQLSAPHCK Q8BH00 dehydrogenase family 8 C9(Carbamidomethyl); 1 1226.746 2.65 member A1 K10(HeavyDimethyl) ITSPLMEPSSIEKIVEIDAHIGCAMSGLI Proteasome subunit N-Term(Dimethyl); K13(Dimethyl); D3YX79 1 3580.880 3.54 ADAK alpha type C23(Carbamidomethyl); K33(Dimethyl) Isoform 2 of ITSRVTNDGEVWRLYAQVHGNGQSEK Q8CD92-2 Tetratricopeptide repeat K26(Dimethyl); K32(Dimethyl) 1 3698.771 3.08 PDENDK protein 27 2-oxoglutarate and iron- IVAFGVGLALVTCLLWSSVGIDDDVAE dependent oxygenase Q9D136 C13(Carbamidomethyl) 2 3400.805 3.11 VVARR domain-containing protein 3 N-Term(Dimethyl:2H(6)13C(2)); IVALQELKMTSSMASYEQLVRQVEAL Adenomatous polyposis D3Z344 K8(HeavyDimethyl); M13(Oxidation); 1 3189.835 2.93 K coli protein 2 (Fragment) K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sarcoplasmic/endoplasm IVEYLQSYDEITAMTGDGVNDAPALK K26(HeavyDimethyl); Q8R429 ic reticulum calcium 1 4458.408 2.87 KAEIGIAMGSGTAVAK K27(HeavyDimethyl); M34(Oxidation); ATPase 1 K42(HeavyDimethyl) 4- N-Term(Dimethyl); IVFVLCSALNPWNKEMGDHLVK P49429 hydroxyphenylpyruvate C6(Carbamidomethyl); K14(Dimethyl); 1 2654.429 3.20 dioxygenase K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- C6(Carbamidomethyl); IVFVLCSALNPWNKEMGDHLVK P49429 hydroxyphenylpyruvate 1 2678.566 2.94 K14(HeavyDimethyl); dioxygenase K22(HeavyDimethyl) Mas-related G-protein IVGLCTFFTGVSLLPAISIER Q8VCJ6 coupled receptor C5(Carbamidomethyl) 2 2293.236 2.58 member F N-Term(Dimethyl:2H(6)13C(2)); IVHHTSFEMMKENPLVNYTHLPTAMM Sulfotransferase family Q9QWG7 K11(HeavyDimethyl); M25(Oxidation); 1 4297.213 3.21 DHSKSPFMR cytosolic 1B member 1 M26(Oxidation); K30(HeavyDimethyl) Isoform C of Serrate N-Term(Dimethyl:2H(6)13C(2)); IVHSLDYYNTCEYPNEDEMPNR Q99MR6-3 RNA effector molecule 1 2795.288 2.76 C11(Carbamidomethyl) homolog N-Term(Dimethyl); K3(Dimethyl); IVKLYDYFSLDTDTFCTVLEYCEGNDL Serine/threonine-protein Q8C0V0 C16(Carbamidomethyl); 1 4043.897 2.89 DFYLK kinase tousled-like 1 C22(Carbamidomethyl); K32(Dimethyl) Eukaryotic translation N-Term(Dimethyl); IVLTNPVCTEVGEK Q9Z0N2 initiation factor 2 1 1614.878 2.36 C8(Carbamidomethyl); K14(Dimethyl) subunit 3, Y-linked Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); IVLTNPVCTEVGEK Q9Z0N1 initiation factor 2 C8(Carbamidomethyl); 1 1630.967 2.30 subunit 3, X-linked K14(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); IVPVDIYVPGCPPTAEALLYGILQLQR Q9DC70 [ubiquinone] iron-sulfur 1 3031.713 2.80 C11(Carbamidomethyl) protein 7, mitochondrial

N-Term(Dimethyl:2H(6)13C(2)); Ethanolamine-phosphate IVRVWCDGCYDMVHYGHSNQLR A2ABY3 C6(Carbamidomethyl); 3 2801.314 3.15 cytidylyltransferase C9(Carbamidomethyl) Glyceraldehyde-3- phosphate C7(Carbamidomethyl); IVSNASCTTNCLAPLAK S4R257 1 1847.937 2.36 dehydrogenase C11(Carbamidomethyl); K17(Dimethyl) (Fragment) Glyceraldehyde-3- C7(Carbamidomethyl); phosphate IVSNASCTTNCLAPLAK S4R257 C11(Carbamidomethyl); 4 1855.972 2.83 dehydrogenase K17(HeavyDimethyl) (Fragment) Glyceraldehyde-3- N-Term(Dimethyl); phosphate IVSNASCTTNCLAPLAK S4R257 C7(Carbamidomethyl); 31 1875.961 6.34 dehydrogenase C11(Carbamidomethyl); K17(Dimethyl) (Fragment) Glyceraldehyde-3- N-Term(Dimethyl:2H(6)13C(2)); phosphate C7(Carbamidomethyl); IVSNASCTTNCLAPLAK S4R257 50 1892.046 6.54 dehydrogenase C11(Carbamidomethyl); (Fragment) K17(HeavyDimethyl) N-Term(Dimethyl); IVSNASCTTNCLSPLAK S4R1W1 Uncharacterized protein C7(Carbamidomethyl); 2 1891.956 2.89 C11(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); IVSNASCTTNCLSPLAK S4R1W1 Uncharacterized protein 2 1908.046 2.23 C11(Carbamidomethyl); K17(HeavyDimethyl) L-lactate dehydrogenase N-Term(Dimethyl); K5(Dimethyl); IVSSKDYCVTANSK P06151 6 1655.861 3.11 A chain C8(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); L-lactate dehydrogenase K5(HeavyDimethyl); IVSSKDYCVTANSK P06151 1 1680.000 2.75 A chain C8(Carbamidomethyl); K14(HeavyDimethyl) WD repeat-containing N-Term(Dimethyl); IVSVGDDQEIHVYDCPI D6RDC7 1 1986.942 2.34 protein 61 C15(Carbamidomethyl) IVTQTPQSPSQNMFTINSETGDIVTVAA N-Term(Dimethyl:2H(6)13C(2)); P39038 Cadherin-4 1 3442.774 2.82 GLDR M13(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); IVTSTYKGGTGDSYNLAIESACTFGDPI Q9WUU7 Cathepsin Z K7(HeavyDimethyl); 1 3108.605 3.02 V C22(Carbamidomethyl) N-Term(Dimethyl); IVVLCGQEAVK P20852 Cytochrome P450 2A5 1 1271.735 2.25 C5(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); IVVLCGQEAVK P20852 Cytochrome P450 2A5 C5(Carbamidomethyl); 2 1287.827 2.15 K11(HeavyDimethyl) IVWTMNEMFIMGSHRYRMTSEGTLFI M11(Oxidation); M18(Oxidation); D3Z2Q7 Protein Hmcn1 1 3346.675 2.64 K K27(HeavyDimethyl) N-Term(Dimethyl); K4(Dimethyl); IVYKMEKDEQIPDGMCIDAEGK Q64374 Regucalcin K7(Dimethyl); C16(Carbamidomethyl); 2 2681.330 3.09 K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); IVYKMEKDEQIPDGMCIDAEGK Q64374 Regucalcin K7(HeavyDimethyl); 1 2713.504 3.04 C16(Carbamidomethyl); K22(HeavyDimethyl) Isoform 2 of Membrane- associated guanylate IWAQSRSMYENR Q6RHR9-2 kinase, WW and PDZ M8(Oxidation) 1 1556.732 1.90 domain-containing protein 1 N-Term(Dimethyl); IWCFGPDGTGPNILTDITK P58252 Elongation factor 2 2 2161.118 3.02 C3(Carbamidomethyl); K19(Dimethyl) Isoform 3 of Pre-mRNA- N-Term(Dimethyl); IWSVPNTSCVQVVR Q99KP6-3 1 1672.874 2.55 processing factor 19 C9(Carbamidomethyl)

Isoform 3 of Pre-mRNA- N-Term(Dimethyl:2H(6)13C(2)); IWSVPNTSCVQVVR Q99KP6-3 1 1680.922 2.12 processing factor 19 C9(Carbamidomethyl) Calcitonin receptor K19(HeavyDimethyl); IYDYLMHSLIHFQVQVTLKRQWTQFK F6XWA0 1 3394.898 3.06 (Fragment) K26(HeavyDimethyl) Acyl-protein thioesterase N-Term(Dimethyl); IYEGMMHSSCQQEMMDVK D3Z111 1 2259.951 2.46 1 C10(Carbamidomethyl); K18(Dimethyl)

Elongation factor 1- N-Term(Dimethyl); K1(Dimethyl); KAAAPAPEEEMDECEQALAAEPK Q9D8N0 4 2569.206 2.95 gamma C14(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Elongation factor 1- K1(HeavyDimethyl); KAAAPAPEEEMDECEQALAAEPK Q9D8N0 1 2593.345 3.09 gamma C14(Carbamidomethyl); K23(HeavyDimethyl) K1(Dimethyl); N-Term(Dimethyl); KAADAHVDAHYYEQNEQPTGTCAACI Isoform Short of P55264-2 C22(Carbamidomethyl); 12 3461.559 6.83 TGGNR Adenosine kinase C25(Carbamidomethyl) K1(HeavyDimethyl); N- KAADAHVDAHYYEQNEQPTGTCAACI Isoform Short of Term(Dimethyl:2H(6)13C(2)); P55264-2 11 3477.643 6.76 TGGNR Adenosine kinase C22(Carbamidomethyl); C25(Carbamidomethyl) Sarcosine KAADWLFSADVNRPPGSTVYTCMLNQ N-Term(Dimethyl); K1(Dimethyl); Q99LB7 dehydrogenase, 2 3153.555 3.19 R C22(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); KAADWLFSADVNRPPGSTVYTCMLNQ Q99LB7 dehydrogenase, K1(HeavyDimethyl); 1 3169.657 3.06 R mitochondrial C22(Carbamidomethyl) Isoform 2 of Acyl- N-Term(Dimethyl:2H(6)13C(2)); KAANVLEGVCGLQPGDR Q8BGA8-2 coenzyme A synthetase K1(HeavyDimethyl); 1 1856.053 2.28 ACSM5, mitochondrial C10(Carbamidomethyl) Non-specific lipid- N-Term(Dimethyl); K1(Dimethyl); KADCTITMADSDLLALMTGK P32020 1 2239.140 4.71 transfer protein C4(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Non-specific lipid- K1(HeavyDimethyl); KADCTITMADSDLLALMTGK P32020 1 2263.291 2.61 transfer protein C4(Carbamidomethyl); K20(HeavyDimethyl) Proliferation-associated N-Term(Dimethyl); K1(Dimethyl); KADVIKAAHLCAEAALR D3YVH7 3 1921.099 3.20 protein 2G4 (Fragment) K6(Dimethyl); C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Proliferation-associated K1(HeavyDimethyl); KADVIKAAHLCAEAALR D3YVH7 3 1945.237 3.58 protein 2G4 (Fragment) K6(HeavyDimethyl); C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Potassium voltage-gated K1(HeavyDimethyl); KASTLEPMESTAQTKGDTRPEAHWNC E9QLW0 channel subfamily C K15(HeavyDimethyl); 1 4853.403 3.91 AHLLNFGCPTGSSFPTL member 2 C26(Carbamidomethyl); C34(Carbamidomethyl) K1(HeavyDimethyl); C2(Carbamidomethyl); Proprotein convertase C6(Carbamidomethyl); KCHESCMECKGPGSK Q04592 1 1902.959 2.07 subtilisin/kexin type 5 C9(Carbamidomethyl); K10(HeavyDimethyl); K15(HeavyDimethyl) Mitochondrial import K1(Dimethyl); N-Term(Dimethyl); inner membrane KCIGKPGGSLDNSEQK P62075 C2(Carbamidomethyl); K5(Dimethyl); 1 1829.976 2.46 translocase subunit K16(Dimethyl) Tim13 K1(HeavyDimethyl); N- Mitochondrial import Term(Dimethyl:2H(6)13C(2)); inner membrane KCIGKPGGSLDNSEQK P62075 C2(Carbamidomethyl); 1 1862.156 2.82 translocase subunit K5(HeavyDimethyl); Tim13 K16(HeavyDimethyl) Isoform 2 of Tyrosine- N-Term(Dimethyl:2H(6)13C(2)); KDAERHLLAPGNMLGSFMIR P08103-2 1 2344.292 2.33 protein kinase HCK K1(HeavyDimethyl); M13(Oxidation) N-alpha- K1(HeavyDimethyl); KDDDDEEIGGPKEELIPEK G3X8Y3 acetyltransferase 15, K12(HeavyDimethyl); 1 2264.255 2.54 NatA auxiliary subunit K19(HeavyDimethyl) KDFQPPVSALQSMHQNISSLLGLIK F8VQ40 Laminin subunit alpha-1 K1(Dimethyl); K25(Dimethyl) 1 2807.522 2.80 Trifunctional enzyme KDGGQYALVAACAAGGQGHAMIVEA N-Term(Dimethyl); K1(Dimethyl); Q99JY0 subunit beta, 11 2917.480 6.12 YPK C12(Carbamidomethyl); K28(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme KDGGQYALVAACAAGGQGHAMIVEA K1(HeavyDimethyl); Q99JY0 subunit beta, 1 2941.596 6.35 YPK C12(Carbamidomethyl); mitochondrial K28(HeavyDimethyl) K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); KDGSASGTTLLEALDCILPPTRPTDKPL Elongation factor 1- P10126 C16(Carbamidomethyl); 1 4223.499 3.19 RLPLQDVYK alpha 1 K26(HeavyDimethyl); K37(HeavyDimethyl) K1(Dimethyl); N-Term(Dimethyl); Baculoviral IAP repeat- C6(Carbamidomethyl); KDIVRCFSCGGCLEK Q9JIB3 1 1912.944 2.26 containing protein 1g C9(Carbamidomethyl); C12(Carbamidomethyl); K15(Dimethyl) Glyoxylate N-Term(Dimethyl); K1(Dimethyl); KDLEQGVVGAHGLLCR Q91Z53 reductase/hydroxypyruv 1 1807.979 2.70 C15(Carbamidomethyl) ate reductase Glyoxylate N-Term(Dimethyl:2H(6)13C(2)); KDLEQGVVGAHGLLCR Q91Z53 reductase/hydroxypyruv K1(HeavyDimethyl); 3 1824.070 3.39 ate reductase C15(Carbamidomethyl) Isoform 3 of E3 KDPELFSGLASNILNFITTSMLNSRNSFI N-Term(Dimethyl); K1(Dimethyl); A2AN08-3 ubiquitin-protein ligase 1 3457.843 2.98 R M21(Oxidation) UBR4 KDSVLLVWEPPIIDGGAK A2ASS6-2 Isoform 2 of Titin K1(Dimethyl); K18(Dimethyl) 2 1993.159 3.26 K1(Dimethyl); N-Term(Dimethyl); KECLAAQLDSGCEEPEVPPPQPDSQET E9Q1Q0 Protein Slc4a1ap C3(Carbamidomethyl); 1 4341.130 3.26 GGPPVEQLRSPR C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Baculoviral IAP repeat- KEGTEEQDTFVSVIYCSGTDR S4R1L5 K1(HeavyDimethyl); 2 2493.257 2.83 containing protein 6 C16(Carbamidomethyl) Indolethylamine N- N-Term(Dimethyl); K1(Dimethyl); KEPGAYDWSSIVQHACELEGDR P40936 5 2603.214 3.49 methyltransferase C16(Carbamidomethyl) Indolethylamine N- N-Term(Dimethyl); K1(Dimethyl); KEPGAYDWSSIVQHACELEGDRSR P40936 2 2846.363 3.50 methyltransferase C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Indolethylamine N- KEPGAYDWSSIVQHACELEGDRSR P40936 K1(HeavyDimethyl); 1 2862.445 2.65 methyltransferase C16(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); KEVGQYPQNSPSPCSVPCK B7ZCC2 Protein Aim1l C14(Carbamidomethyl); 1 2246.118 2.44 C18(Carbamidomethyl); K19(Dimethyl) Glucosamine 6- N-Term(Dimethyl); K1(Dimethyl); KFDYTVSEENYMCR Q9JK38 phosphate N- 3 1897.841 3.06 C13(Carbamidomethyl) acetyltransferase CDGSH iron-sulfur N-Term(Dimethyl); K1(Dimethyl); KFPFCDGAHIK Q91WS0 domain-containing 1 1403.745 2.48 C5(Carbamidomethyl); K11(Dimethyl) protein 1 K1(Dimethyl); N-Term(Dimethyl); KFPVLNPATEEVICHVEEGDKADVDK P24549 Retinal dehydrogenase 1 C14(Carbamidomethyl); K21(Dimethyl); 2 3051.575 3.46 K26(Dimethyl) Sushi, von Willebrand K1(HeavyDimethyl); KFSAAFETTLGNMVPSFCNDADDIDCR factor type A, EGF and C18(Carbamidomethyl); A2AVA0 1 3852.862 3.33 LEDLTK pentraxin domain- C26(Carbamidomethyl); containing protein 1 K33(HeavyDimethyl) Solute carrier organic KFTDEGNPEPVNNNGYSCVPSDEKNSE N-Term(Dimethyl); K1(Dimethyl); Q9JJL3 anion transporter family 3 3422.555 4.97 TPL C18(Carbamidomethyl); K24(Dimethyl) member 1B2 N-Term(Dimethyl:2H(6)13C(2)); Solute carrier organic KFTDEGNPEPVNNNGYSCVPSDEKNSE K1(HeavyDimethyl); Q9JJL3 anion transporter family 1 3446.696 5.72 TPL C18(Carbamidomethyl); member 1B2 K24(HeavyDimethyl) N-Term(Dimethyl); K1(Dimethyl); Eukaryotic translation KFVLCPECENPETDLHVNPK P59325 C5(Carbamidomethyl); 2 2510.233 3.60 initiation factor 5 C8(Carbamidomethyl); K20(Dimethyl) Methylcrotonoyl-CoA K1(Dimethyl); N-Term(Dimethyl); KGAHFVQLCCQR Q3ULD5 carboxylase beta chain, C9(Carbamidomethyl); 1 1559.786 2.74 mitochondrial C10(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); Isoform 2 of CD302 KGDCEISSVEGTLCK Q9DCG2-2 C4(Carbamidomethyl); 3 1766.858 2.85 antigen C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); Isoform 2 of CD302 KGDCEISSVEGTLCK Q9DCG2-2 C4(Carbamidomethyl); 3 1790.989 2.60 antigen C14(Carbamidomethyl); K15(HeavyDimethyl) Insulin-like growth K1(HeavyDimethyl); KGEPKTHPEGEQEEVTEATR Q8CAR0 1 2324.227 2.31 factor I K5(HeavyDimethyl) K1(Dimethyl); N-Term(Dimethyl); KGESVMVVPTLSEEEAKQCFPK O08709 Peroxiredoxin-6 K17(Dimethyl); C19(Carbamidomethyl); 7 2605.358 4.94 K22(Dimethyl) K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); KGESVMVVPTLSEEEAKQCFPK O08709 Peroxiredoxin-6 K17(HeavyDimethyl); 7 2637.532 5.58 C19(Carbamidomethyl); K22(HeavyDimethyl) N-Term(Dimethyl); K1(Dimethyl); KGESVMVVPTLSEEEAKQCFPK O08709 Peroxiredoxin-6 M6(Oxidation); K17(Dimethyl); 2 2621.364 3.06 C19(Carbamidomethyl); K22(Dimethyl) K1(Dimethyl); M8(Oxidation); KGFSLRNMSLCVVDGVR Q9JID9 SH2B adapter protein 2 1 1982.015 2.71 C11(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); K1(Dimethyl); KGFTTCIVTNNWLDDGDKR P34914-2 Bifunctional epoxide 1 2324.172 2.60 C6(Carbamidomethyl); K18(Dimethyl) hydrolase 2 Uncharacterized protein K1(HeavyDimethyl); KGHAESRNISPEELK Q80Y39 1 1767.030 2.40 C10orf62 homolog K15(HeavyDimethyl) E3 ubiquitin-protein N-Term(Dimethyl); K1(Dimethyl); KGKTAQGLSPVDQR E9QME5 4 1568.918 3.02 ligase TRIM33 K3(Dimethyl) N-Term(Dimethyl); K1(Dimethyl); KGLIAAICAGPTALLAHEVGFGCK A2A815 Protein DJ-1 (Fragment) C8(Carbamidomethyl); 2 2538.394 3.51 C23(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KGLIAAICAGPTALLAHEVGFGCK A2A815 Protein DJ-1 (Fragment) C8(Carbamidomethyl); 1 2562.526 3.75 C23(Carbamidomethyl); K24(HeavyDimethyl) KGNALEWVQADASQR E9Q2M2 Tonsoku-like protein K1(Dimethyl) 1 1700.887 2.70 KGQVLSVCVEEENIIPYITNVLQNPDLA K1(HeavyDimethyl); Q68FD5 Clathrin heavy chain 1 1 3460.874 2.77 LR C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); KGRDSQDSSEAHR Q8CJ40-2 Isoform 2 of Rootletin 1 1544.852 1.96 K1(HeavyDimethyl) K1(Dimethyl); N-Term(Dimethyl); KGTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 1 1888.886 2.34 M6(Oxidation); C13(Carbamidomethyl)

K1(HeavyDimethyl); N- KGTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 Term(Dimethyl:2H(6)13C(2)); 1 1904.978 2.12 M6(Oxidation); C13(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); KGTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 4 1872.892 4.61 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); KGTDIMYTGTLDCWR P51881 ADP/ATP translocase 2 K1(HeavyDimethyl); 9 1888.982 3.63 C13(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); KGTDIMYTGTLDCWRK P51881 ADP/ATP translocase 2 1 2029.025 2.47 C13(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KGTDIMYTGTLDCWRK P51881 ADP/ATP translocase 2 1 2053.159 2.32 C13(Carbamidomethyl); K16(HeavyDimethyl) Isoform Cytoplasmic+peroxisom N-Term(Dimethyl); K1(Dimethyl); KGVLFGVPGAFTPGCSK P99029-2 4 1805.997 2.86 al of Peroxiredoxin-5, C15(Carbamidomethyl); K17(Dimethyl) mitochondrial Isoform N-Term(Dimethyl:2H(6)13C(2)); Cytoplasmic+peroxisom K1(HeavyDimethyl); KGVLFGVPGAFTPGCSK P99029-2 1 1830.130 2.43 al of Peroxiredoxin-5, C15(Carbamidomethyl); mitochondrial K17(HeavyDimethyl) N-Term(Dimethyl); K1(Dimethyl); KGYFEDRRPSANCDPYAVTEAIVR P15105 Glutamine synthetase 1 2870.424 2.72 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); KGYFEDRRPSANCDPYAVTEAIVR P15105 Glutamine synthetase K1(HeavyDimethyl); 1 2886.492 2.66 C13(Carbamidomethyl) Glutathione S- N-Term(Dimethyl); K1(Dimethyl); KHNLCGETEEER D3YX76 2 1557.731 3.62 transferase Mu 2 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- KHNLCGETEEER D3YX76 K1(HeavyDimethyl); 2 1573.820 3.52 transferase Mu 2 C5(Carbamidomethyl) K1(Dimethyl); N-Term(Dimethyl); Proteasome subunit KICALDDNVCMAFAGLTADAR Q9Z2U0 C3(Carbamidomethyl); 2 2368.152 3.48 alpha type-7 C10(Carbamidomethyl) K1(HeavyDimethyl); N- Proteasome subunit Term(Dimethyl:2H(6)13C(2)); KICALDDNVCMAFAGLTADAR Q9Z2U0 1 2384.261 3.11 alpha type-7 C3(Carbamidomethyl); C10(Carbamidomethyl) K1(HeavyDimethyl); M9(Oxidation); KISNDMEEMCGILNLYMYEDLNYR A6NAU3 Alpha26-takusan 1 3082.447 2.67 C10(Carbamidomethyl); M17(Oxidation) KITAFVPNDGCLNFIEENDEVLVAGFG 40S ribosomal protein N-Term(Dimethyl); K1(Dimethyl); P62267 2 3180.618 3.01 R S23 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); KITAFVPNDGCLNFIEENDEVLVAGFG 40S ribosomal protein P62267 K1(HeavyDimethyl); 2 3196.696 3.94 R S23 C11(Carbamidomethyl) Peptidyl-prolyl cis-trans N-Term(Dimethyl); K1(Dimethyl); KITISDCGQL P17742 10 1190.641 2.66 isomerase A C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Peptidyl-prolyl cis-trans KITISDCGQL P17742 K1(HeavyDimethyl); 7 1206.730 2.63 isomerase A C7(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); KIWCFGPDGTGPNILTDITK P58252 Elongation factor 2 1 2317.226 2.79 C4(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KIWCFGPDGTGPNILTDITK P58252 Elongation factor 2 1 2341.391 2.62 C4(Carbamidomethyl); K20(HeavyDimethyl) K1(Dimethyl); N-Term(Dimethyl); KKAFSTCSSHMIVISMSYGSCIFIYVKP K2(Dimethyl); C7(Carbamidomethyl); Q8VFI3 Olfactory receptor 1 3943.002 3.36 SANER M11(Oxidation); M16(Oxidation); C21(Carbamidomethyl); K27(Dimethyl) K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); KKCLGELICTLNAANVPAGTEVVCAPP Triosephosphate K2(HeavyDimethyl); P17751 1 3928.173 4.02 TAYIDFAR isomerase C3(Carbamidomethyl); C9(Carbamidomethyl); C24(Carbamidomethyl) ATPase family AAA KLEDLGVFNETEESNLTMYTR G3X963 domain-containing K1(HeavyDimethyl) 1 2525.300 2.65 protein 2 N-Term(Dimethyl:2H(6)13C(2)); KLEFSSSADSLSDWADMDDFDMSASD Bloom syndrome protein O88700 K1(HeavyDimethyl); M22(Oxidation); 1 4224.068 2.79 AFASLAKNPATR homolog K33(HeavyDimethyl) Isoform 2 of Histone- N-Term(Dimethyl:2H(6)13C(2)); lysine N- K1(HeavyDimethyl); KLGDSSKNSDSQSVSSNTDADTTQEK Q3U8K7-2 1 2873.575 2.57 methyltransferase K7(HeavyDimethyl); SUV420H1 K26(HeavyDimethyl) 3-hydroxyacyl-CoA N-Term(Dimethyl); K1(Dimethyl); KLGESCIFAPANVTSEK O08756 2 1935.022 3.87 dehydrogenase type-2 C6(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-hydroxyacyl-CoA K1(HeavyDimethyl); KLGESCIFAPANVTSEK O08756 1 1959.156 3.36 dehydrogenase type-2 C6(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); KLGGNPEKINPVCPADLVIDHSIQVDF Cytoplasmic aconitate K1(HeavyDimethyl); P28271 1 3353.903 3.70 NR hydratase K8(HeavyDimethyl); C13(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); KLLMMAGIDDCYTSAR L7N240 Protein Gm6139 5 1900.924 3.79 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); KLLMMAGIDDCYTSAR L7N240 Protein Gm6139 K1(HeavyDimethyl); 4 1917.015 2.85 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KLNCQVIGASVDSHFCHLAWINTPK P35700 Peroxiredoxin-1 C4(Carbamidomethyl); 2 3003.673 2.91 C16(Carbamidomethyl); K25(HeavyDimethyl) Isoform Alpha-1 of K1(HeavyDimethyl); KLPMFSELPCEDQIILLK P63058-2 Thyroid hormone C10(Carbamidomethyl); 1 2246.287 2.41 receptor alpha K18(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl); K1(Dimethyl); KLRGEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate 14 2209.111 4.12 C11(Carbamidomethyl); K18(Dimethyl) dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); Cytosolic 10- K1(HeavyDimethyl); KLRGEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate 7 2233.246 3.61 C11(Carbamidomethyl); dehydrogenase K18(HeavyDimethyl) Aldehyde KLSLELGGKNPAIIFEDANLEECIPATV N-Term(Dimethyl); K1(Dimethyl); Q8BH00 dehydrogenase family 8 2 3281.799 4.83 R K9(Dimethyl); C23(Carbamidomethyl) member A1 N-Term(Dimethyl:2H(6)13C(2)); Aldehyde KLSLELGGKNPAIIFEDANLEECIPATV K1(HeavyDimethyl); Q8BH00 dehydrogenase family 8 1 3305.915 3.86 R K9(HeavyDimethyl); member A1 C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Kynurenine- K1(HeavyDimethyl); KLTAIPVSAFCDSK Q71RI9-2 -oxoglutarate 1 1645.033 2.15 C11(Carbamidomethyl); transaminase 3 K14(HeavyDimethyl) 2-hydroxyacyl-CoA N-Term(Dimethyl); K1(Dimethyl); KLVEQCSLPFLPTPMGK D3YZ54 2 2029.121 2.71 lyase 1 C6(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-hydroxyacyl-CoA K1(HeavyDimethyl); KLVEQCSLPFLPTPMGK D3YZ54 2 2053.246 3.56 lyase 1 C6(Carbamidomethyl); K17(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl); K1(Dimethyl); KLVEYCQR Q8R0Y6 formyltetrahydrofolate 3 1151.622 3.08 C6(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); KLVEYCQR Q8R0Y6 formyltetrahydrofolate K1(HeavyDimethyl); 4 1167.710 3.44 dehydrogenase C6(Carbamidomethyl) N-Term(Dimethyl); K1(Dimethyl); Electron transfer KLVKEIIAVSCGPSQCQETIR Q9DCW4 K4(Dimethyl); C11(Carbamidomethyl); 13 2500.350 4.85 flavoprotein subunit beta C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); Electron transfer KLVKEIIAVSCGPSQCQETIR Q9DCW4 K4(HeavyDimethyl); 11 2524.482 5.51 flavoprotein subunit beta C11(Carbamidomethyl); C16(Carbamidomethyl) Mitochondrial KLYPSESYLQNYEVAYPDCSPVHLISE N-Term(Dimethyl); K1(Dimethyl); Q922Q1 amidoxime reducing 3 4227.091 4.29 ASLVDLNTR C19(Carbamidomethyl) component 2 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); KLYPSESYLQNYEVAYPDCSPVHLISE Q922Q1 amidoxime reducing K1(HeavyDimethyl); 3 4243.192 5.54 ASLVDLNTR component 2 C19(Carbamidomethyl) Vacuolar protein sorting- K1(HeavyDimethyl); M2(Oxidation); KMKMLAQPLCPLSHLSHHHLQHTTQA F6RYM7 associated protein VTA1 K3(HeavyDimethyl); M4(Oxidation); 1 4433.376 2.98 TWHQAATVAYR homolog (Fragment) C10(Carbamidomethyl) Bifunctional ATP- dependent KMVNSVEGCADDALAGLVASNPDLQL N-Term(Dimethyl); K1(Dimethyl); Q8VC30 dihydroxyacetone 1 3334.706 4.74 LQGHR C9(Carbamidomethyl) kinase/FAD-AMP lyase (cyclizing) Bifunctional ATP- dependent N-Term(Dimethyl:2H(6)13C(2)); KMVNSVEGCADDALAGLVASNPDLQL Q8VC30 dihydroxyacetone K1(HeavyDimethyl); 2 3350.820 5.43 LQGHR kinase/FAD-AMP lyase C9(Carbamidomethyl) (cyclizing) K1(HeavyDimethyl); KMWKSGEIPTEQHPGASASPPCASPPV Homeobox protein DLX- P40764 K4(HeavyDimethyl); 1 4289.149 2.77 SAPASWDFGAPQR 2 C22(Carbamidomethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); K1(Dimethyl); KNANCSIEESFQR P38060 CoA lyase, 1 1638.783 3.06 C5(Carbamidomethyl) mitochondrial Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); KNANCSIEESFQR P38060 CoA lyase, K1(HeavyDimethyl); 1 1654.872 2.28 mitochondrial C5(Carbamidomethyl) KNIISYSGCMTQLFFFLFFVVSESFILSA K1(HeavyDimethyl); Q60882 Olfactory receptor 145 1 4068.044 2.98 MAYDR C9(Carbamidomethyl) KNISYNECMTQLFTSHLLAGVEIFILVS K1(HeavyDimethyl); Q7TR14 Olfactory receptor 1 3849.960 3.20 MALDR C8(Carbamidomethyl) Peroxisomal N-Term(Dimethyl); K1(Dimethyl); KNNIHCNTIAPNAGSR P51660 multifunctional enzyme 3 1822.930 3.58 C6(Carbamidomethyl) type 2 Peroxisomal N-Term(Dimethyl:2H(6)13C(2)); KNNIHCNTIAPNAGSR P51660 multifunctional enzyme K1(HeavyDimethyl); 4 1839.019 4.24 type 2 C6(Carbamidomethyl) Glutathione S- KNNIPFQMHTVELR Q64471 K1(Dimethyl) 1 1754.942 2.26 transferase theta-1 K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); Glutathione S- KPFDDAKCVESAK P30115 K7(HeavyDimethyl); 1 1639.028 2.06 transferase A3 C8(Carbamidomethyl); K13(HeavyDimethyl) Transcription factor 7- K1(Dimethyl); K5(Dimethyl); KPHVKKPLNAFMLYMK Q9Z1J1 1 2057.188 2.38 like 1 K6(Dimethyl); K16(Dimethyl) K1(Dimethyl); N-Term(Dimethyl); KPNQPYEWISYKEVAELAECIGSGLIQ Long-chain-fatty-acid-- D3Z041 K12(Dimethyl); C20(Carbamidomethyl); 1 3362.777 2.91 K CoA ligase 1 K28(Dimethyl) K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); KPNQPYEWISYKEVAELAECIGSGLIQ Long-chain-fatty-acid-- D3Z041 K12(HeavyDimethyl); 1 3394.958 3.68 K CoA ligase 1 C20(Carbamidomethyl); K28(HeavyDimethyl) KPRTLLSPPPTSPTTSTPEPDTSTVPQD Polycomb protein N-Term(Dimethyl); K1(Dimethyl); F6UK33 1 4820.444 3.26 AATVPSSAMQAPTAVFDR SCMH1 (Fragment) M37(Oxidation) Dimethylaniline N-Term(Dimethyl); K1(Dimethyl); KQPDFSTSGQWQVVTECEGK P97872 monooxygenase [N- 10 2395.170 4.22 C17(Carbamidomethyl); K20(Dimethyl) oxide-forming] 5 N-Term(Dimethyl:2H(6)13C(2)); Dimethylaniline K1(HeavyDimethyl); KQPDFSTSGQWQVVTECEGK P97872 monooxygenase [N- 3 2419.289 4.24 C17(Carbamidomethyl); oxide-forming] 5 K20(HeavyDimethyl) K1(HeavyDimethyl); N- KRCGDSHPESPVGFGHMSTTGHLCGLI Choline/ethanolamineph Term(Dimethyl:2H(6)13C(2)); D6RFR8 1 4698.374 3.68 LPVLVAFSFTSLWMP osphotransferase 1 C3(Carbamidomethyl); C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Carboxymethylenebuten K1(HeavyDimethyl); KREDCSPADKPYIEEAR Q8R1G2 1 2172.209 2.63 olidase homolog C5(Carbamidomethyl); K10(HeavyDimethyl) Heat shock protein HSP N-Term(Dimethyl); K1(Dimethyl); KRGFEVVYMTEPIDEYCVQQLK P11499 4 2816.437 3.93 90-beta C17(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP K1(HeavyDimethyl); KRGFEVVYMTEPIDEYCVQQLK P11499 2 2840.565 3.45 90-beta C17(Carbamidomethyl); K22(HeavyDimethyl) MORC family CW-type K1(HeavyDimethyl); KRSLAVSDEEEAEEEAEK Q69ZX6 1 2121.124 2.52 zinc finger protein 2A K18(HeavyDimethyl) Metal transporter KSADGERASEENSNLTPLIT Q0GA42 K1(Dimethyl) 1 2160.101 2.73 CNNM1 N-Term(Dimethyl); K1(Dimethyl); KTCTTVAFTQVNSEDK D3YXT4 Uncharacterized protein 2 1912.943 2.53 C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KTCTTVAFTQVNSEDK D3YXT4 Uncharacterized protein 1 1937.097 2.30 C3(Carbamidomethyl); K16(HeavyDimethyl) K1(HeavyDimethyl); N- Term(Dimethyl:2H(6)13C(2)); KTCTTVAFTQVNSEDKGALAK D3YXT4 Uncharacterized protein C3(Carbamidomethyl); 2 2413.442 2.97 K16(HeavyDimethyl); K21(HeavyDimethyl) Aldehyde K1(Dimethyl); N-Term(Dimethyl); KTFPTVNPSTGEVICQVAEGNKEDVD P47738 dehydrogenase, C15(Carbamidomethyl); K22(Dimethyl); 4 3074.561 5.09 K mitochondrial K27(Dimethyl) K1(HeavyDimethyl); N- Aldehyde Term(Dimethyl:2H(6)13C(2)); KTFPTVNPSTGEVICQVAEGNKEDVD P47738 dehydrogenase, C15(Carbamidomethyl); 2 3106.734 3.86 K mitochondrial K22(HeavyDimethyl); K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); KTGVSSSHLQALWIGYSTEGLSAALAS Isoform 2 of Protein Q0VGY8-2 K1(HeavyDimethyl); 1 4041.285 3.53 LRNLYTPNVK TANC1 K37(HeavyDimethyl) Isoform 2 of Nitrilase N-Term(Dimethyl); K1(Dimethyl); KTHLCDVEIPGQGPMR Q8VDK1-2 4 1893.966 2.79 homolog 1 C5(Carbamidomethyl) Origin recognition N-Term(Dimethyl); K1(Dimethyl); KTNYSMDSLCSWYSAVTQK A2AT40 complex subunit 3 M6(Oxidation); C10(Carbamidomethyl); 1 2369.131 3.33 (Fragment) K19(Dimethyl) N-Term(Dimethyl); K1(Dimethyl); KTSYPDCIK Q921I1 Serotransferrin 1 1195.635 2.41 C7(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KTSYPDCIK Q921I1 Serotransferrin 1 1219.767 2.09 C7(Carbamidomethyl); K9(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl); K1(Dimethyl); KTTGLVGLAVCDTPHER Q9CPP6 [ubiquinone] 1 alpha 2 1910.019 2.42 C11(Carbamidomethyl) subcomplex subunit 5

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); KTTGLVGLAVCDTPHER Q9CPP6 [ubiquinone] 1 alpha K1(HeavyDimethyl); 1 1926.100 2.66 subcomplex subunit 5 C11(Carbamidomethyl)

Carbamoyl-phosphate N-Term(Dimethyl); K1(Dimethyl); KTVVVNCNPETVSTDFDECDKLYFEEL Q8C196 synthase [ammonia], C7(Carbamidomethyl); 4 3820.850 4.96 SLER mitochondrial C19(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K1(HeavyDimethyl); KTVVVNCNPETVSTDFDECDKLYFEEL Q8C196 synthase [ammonia], C7(Carbamidomethyl); 1 3844.962 3.66 SLER mitochondrial C19(Carbamidomethyl); K21(HeavyDimethyl) Glycerol-3-phosphate N-Term(Dimethyl); K1(Dimethyl); KVCIVGSGNWGSAIAK E0CXN5 dehydrogenase 3 1730.954 2.83 C3(Carbamidomethyl); K16(Dimethyl) [NAD(+)], cytoplasmic

Homogentisate 1,2- N-Term(Dimethyl); K1(Dimethyl); KVDFVSGLYTLCGAGDIK O09173 5 2027.084 3.66 dioxygenase C12(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- K1(HeavyDimethyl); KVDFVSGLYTLCGAGDIK O09173 1 2051.222 2.25 dioxygenase C12(Carbamidomethyl); K18(HeavyDimethyl) Thiosulfate N-Term(Dimethyl); K1(Dimethyl); KVDLSQPLIATCR P52196 8 1556.880 3.40 sulfurtransferase C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Thiosulfate KVDLSQPLIATCR P52196 K1(HeavyDimethyl); 8 1572.966 3.66 sulfurtransferase C12(Carbamidomethyl) Thiosulfate N-Term(Dimethyl); K1(Dimethyl); KVDLSQPLIATCRK P52196 2 1713.005 2.76 sulfurtransferase C12(Carbamidomethyl); K14(Dimethyl) Ubiquitin fusion KVEEDEAGGRFIAFSGEGQSLR P70362 degradation protein 1 K1(Dimethyl) 1 2410.235 3.70 homolog Alcohol dehydrogenase N-Term(Dimethyl); K1(Dimethyl); KVICIPK Q9JII6 1 941.621 2.19 [NADP(+)] C4(Carbamidomethyl); K7(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase K1(HeavyDimethyl); KVICIPK Q9JII6 2 965.755 2.03 [NADP(+)] C4(Carbamidomethyl); K7(HeavyDimethyl) K1(Dimethyl); M14(Oxidation); KVLGDSSLSSSAVMVLVNAVYFK Q9D695 Serpin B7 1 2486.335 2.62 K23(Dimethyl) Cytosolic 10- K1(Dimethyl); N-Term(Dimethyl); KVSLELGGKSPLIIFADCDLNK Q8R0Y6 formyltetrahydrofolate K9(Dimethyl); C18(Carbamidomethyl); 1 2529.435 2.85 dehydrogenase K22(Dimethyl) K1(HeavyDimethyl); N- Cytosolic 10- Term(Dimethyl:2H(6)13C(2)); KVSLELGGKSPLIIFADCDLNK Q8R0Y6 formyltetrahydrofolate K9(HeavyDimethyl); 1 2561.621 2.84 dehydrogenase C18(Carbamidomethyl); K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KVVVCDNGTGFVK P61161 Actin-related protein 2 1 1530.967 2.49 C5(Carbamidomethyl); K13(HeavyDimethyl) N-Term(Dimethyl); K1(Dimethyl); KYCGLPGEYWLGNDKISQLTR Q8K0E8 Fibrinogen beta chain 2 2582.355 2.97 C3(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K1(HeavyDimethyl); KYCGLPGEYWLGNDKISQLTR Q8K0E8 Fibrinogen beta chain 1 2606.472 2.86 C3(Carbamidomethyl); K15(HeavyDimethyl) Phosphoenolpyruvate N-Term(Dimethyl); K1(Dimethyl); KYDNCWLALTDPR Q9Z2V4 carboxykinase, cytosolic 1 1707.851 2.58 C5(Carbamidomethyl) [GTP] Phosphoenolpyruvate N-Term(Dimethyl:2H(6)13C(2)); KYDNCWLALTDPR Q9Z2V4 carboxykinase, cytosolic K1(HeavyDimethyl); 2 1723.944 2.87 [GTP] C5(Carbamidomethyl) Eukaryotic translation N-Term(Dimethyl); K1(Dimethyl); KYEDICPSTHNMDVPNIK Q8BGY2 1 2245.096 2.94 initiation factor 5A-2 C6(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Eukaryotic translation K1(HeavyDimethyl); KYEDICPSTHNMDVPNIK Q8BGY2 1 2269.229 2.87 initiation factor 5A-2 C6(Carbamidomethyl); K18(HeavyDimethyl) Trifunctional enzyme N-Term(Dimethyl); K1(Dimethyl); KYESAYGTQFTPCQLLLDHANNSSK Q8BMS1 subunit alpha, 4 2956.451 4.31 C13(Carbamidomethyl); K25(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme K1(HeavyDimethyl); KYESAYGTQFTPCQLLLDHANNSSK Q8BMS1 subunit alpha, 1 2980.579 3.97 C13(Carbamidomethyl); mitochondrial K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ras GTPase-activating- K1(HeavyDimethyl); KYFQEACDVPEPEEK Q3UQ44 1 1977.061 2.67 like protein IQGAP2 C7(Carbamidomethyl); K15(HeavyDimethyl) K1(HeavyDimethyl); KYMVYVFLCIWSFSFSYSSSR K7N688 MCG1036591 1 2693.351 2.56 C9(Carbamidomethyl) KYREGLPTTSMSAPAICLSVLGMSSLM N-Term(Dimethyl); K1(Dimethyl); E9Q8W4 Protein Gm10935 1 3721.952 2.93 VAAAVTRP C17(Carbamidomethyl) Glucokinase regulatory N-Term(Dimethyl:2H(6)13C(2)); LAAASSVCEVVR Q91X44 4 1297.728 2.33 protein C8(Carbamidomethyl) Estradiol 17-beta- N-Term(Dimethyl); LAAEGAAVAACDLDGAAAQDTVR G3UX44 dehydrogenase 8 9 2244.090 7.43 C11(Carbamidomethyl) (Fragment) Estradiol 17-beta- N-Term(Dimethyl:2H(6)13C(2)); LAAEGAAVAACDLDGAAAQDTVR G3UX44 dehydrogenase 8 6 2252.133 7.86 C11(Carbamidomethyl) (Fragment) C8(Carbamidomethyl); LAAGPGRCAGRVELFYQGSWGTVCD Protein Cd163l1 Q8CGY7 C24(Carbamidomethyl); 2 4283.931 2.88 DAWDLQDAQVVCR (Precursor) C37(Carbamidomethyl) 2-amino-3-ketobutyrate N-Term(Dimethyl); LAAQYGALVFVDECHATGFLGPTGR E9PWY6 coenzyme A ligase, 1 2678.333 3.58 C14(Carbamidomethyl) mitochondrial

2-amino-3-ketobutyrate N-Term(Dimethyl:2H(6)13C(2)); LAAQYGALVFVDECHATGFLGPTGR E9PWY6 coenzyme A ligase, 1 2686.408 2.56 C14(Carbamidomethyl) mitochondrial Superoxide dismutase N-Term(Dimethyl); LACGVIGIAQ P08228 4 1029.575 2.32 [Cu-Zn] C3(Carbamidomethyl) Superoxide dismutase N-Term(Dimethyl:2H(6)13C(2)); LACGVIGIAQ P08228 1 1037.619 1.95 [Cu-Zn] C3(Carbamidomethyl) Transitional LADDVDLEQVANETHGHVGADLAAL N-Term(Dimethyl); Q01853 endoplasmic reticulum 1 3700.815 3.26 CSEAALQAIR C26(Carbamidomethyl) ATPase Transitional LADDVDLEQVANETHGHVGADLAAL N-Term(Dimethyl:2H(6)13C(2)); Q01853 endoplasmic reticulum 1 3708.871 3.66 CSEAALQAIR C26(Carbamidomethyl) ATPase Cystathionine gamma- N-Term(Dimethyl); LADIGACAQIVHK Q8VCN5 1 1451.800 2.90 lyase C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cystathionine gamma- LADIGACAQIVHK Q8VCN5 C7(Carbamidomethyl); 6 1467.889 3.27 lyase K13(HeavyDimethyl) LADVADADSEADENEQVSAV Q5NCJ0 Protein Rapgef6 2 2047.919 2.45 Long-chain specific acyl- N-Term(Dimethyl:2H(6)13C(2)); LAELKTHICVTR P51174 CoA dehydrogenase, K5(HeavyDimethyl); 1 1512.952 2.45 mitochondrial C9(Carbamidomethyl) N-Term(Dimethyl); Isoform 2 of Adenylate LAENFCVCHLATGDMLR Q9WTP6-2 C6(Carbamidomethyl); 8 2034.951 4.23 kinase 2, mitochondrial C8(Carbamidomethyl) N-Term(Dimethyl); Isoform 2 of Adenylate LAENFCVCHLATGDMLR Q9WTP6-2 C6(Carbamidomethyl); 1 2050.946 3.26 kinase 2, mitochondrial C8(Carbamidomethyl); M15(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Adenylate LAENFCVCHLATGDMLR Q9WTP6-2 C6(Carbamidomethyl); 2 2042.997 4.37 kinase 2, mitochondrial C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Adenylate LAENFCVCHLATGDMLR Q9WTP6-2 C6(Carbamidomethyl); 3 2058.994 2.62 kinase 2, mitochondrial C8(Carbamidomethyl); M15(Oxidation)

14-3-3 protein zeta/delta N-Term(Dimethyl); LAEQAERYDDMAACMK D3YXF4 9 1957.879 4.44 (Fragment) C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 14-3-3 protein zeta/delta LAEQAERYDDMAACMK D3YXF4 C14(Carbamidomethyl); 5 1973.966 4.22 (Fragment) K16(HeavyDimethyl) Isoform 2 of 14-3-3 N-Term(Dimethyl); LAEQAERYDDMATCMK P68254-2 1 1987.891 2.81 protein theta C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of 14-3-3 LAEQAERYDDMATCMK P68254-2 C14(Carbamidomethyl); 1 2003.978 2.33 protein theta K16(HeavyDimethyl) Delta-1-pyrroline-5- LAGECGGKNFHFVHSSADVDSVVSGT carboxylate N-Term(Dimethyl); Q8CHT0 1 3002.499 4.58 LR dehydrogenase, C5(Carbamidomethyl); K8(Dimethyl) mitochondrial Delta-1-pyrroline-5- N-Term(Dimethyl:2H(6)13C(2)); LAGECGGKNFHFVHSSADVDSVVSGT carboxylate Q8CHT0 C5(Carbamidomethyl); 2 3018.571 4.12 LR dehydrogenase, K8(HeavyDimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LAGQIFLGGSIVRGGSVQVLEDQELTC Selenium-binding C27(Carbamidomethyl); P17563 1 4030.372 3.73 QPEPLVVKGK protein 1 K35(HeavyDimethyl); K37(HeavyDimethyl) Dipeptidyl LAHRVSALEDQQFLIIHATADEK Q5U4C2 aminopeptidase-like K23(HeavyDimethyl) 1 2641.466 2.24 protein 6 4- N-Term(Dimethyl); K3(Dimethyl); LAKEQGATVLCGGEVYVPEDPKLK Q9JLJ2 trimethylaminobutyralde C11(Carbamidomethyl); K22(Dimethyl); 2 2713.480 3.33 hyde dehydrogenase K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- K3(HeavyDimethyl); LAKEQGATVLCGGEVYVPEDPKLK Q9JLJ2 trimethylaminobutyralde C11(Carbamidomethyl); 2 2745.665 3.79 hyde dehydrogenase K22(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LALYTACGGVNPQQCLPITLDVGTENE NADP-dependent malic C7(Carbamidomethyl); P06801 2 4416.391 4.58 ELLKDPLYIGLR enzyme C15(Carbamidomethyl); K31(HeavyDimethyl) Sarcosine LAPGTQASPLVPAFEGDCYYLAVGGA N-Term(Dimethyl); Q99LB7 dehydrogenase, 2 4955.437 3.77 VAQHNWSHINTVLQDQEFR C18(Carbamidomethyl) mitochondrial Sarcosine LAPGTQASPLVPAFEGDCYYLAVGGA N-Term(Dimethyl:2H(6)13C(2)); Q99LB7 dehydrogenase, 5 4963.483 4.37 VAQHNWSHINTVLQDQEFR C18(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LAQTLSCDYNQPSPEVVSVAASSPTSS C7(Carbamidomethyl); Q6ZWQ0-2 Isoform 2 of Nesprin-2 1 3454.864 2.93 PPTKK K31(HeavyDimethyl); K32(HeavyDimethyl) Dehydrogenase/reductas LAYGVHPVEVAEEVMRTVRR Q8CHS7 e SDR family member N-Term(Dimethyl); M15(Oxidation) 3 2355.293 2.48 7C D-dopachrome N-Term(Dimethyl); LCAATATILDKPEDR O35215 11 1729.908 3.77 decarboxylase C2(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); D-dopachrome LCAATATILDKPEDR O35215 C2(Carbamidomethyl); 8 1746.003 4.50 decarboxylase K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); LCCRMTFGTAGLRSAMGAGFCYINDL Glucose 1,6- E0CX81 C3(Carbamidomethyl); 1 4251.110 3.22 TVIQSTQGMYK bisphosphate synthase C21(Carbamidomethyl); K37(HeavyDimethyl) Mitochondrial LCDPSEQALYGKLPIFGQYFALENPGTI N-Term(Dimethyl); Q9CW42 amidoxime-reducing 1 3353.744 3.34 R C2(Carbamidomethyl); K12(Dimethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LCDPSEQALYGKLPIFGQYFALENPGTI Q9CW42 amidoxime-reducing C2(Carbamidomethyl); 3 3369.811 5.42 R component 1 K12(HeavyDimethyl) Mitochondrial LCDPSEQALYGKLPIFGQYFALENPGTI N-Term(Dimethyl); Q9CW42 amidoxime-reducing 1 4395.284 3.15 RVGDPVYLLGQ C2(Carbamidomethyl); K12(Dimethyl) component 1 Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LCDPSEQALYGKLPIFGQYFALENPGTI Q9CW42 amidoxime-reducing C2(Carbamidomethyl); 2 4411.392 5.43 RVGDPVYLLGQ component 1 K12(HeavyDimethyl) N-Term(Dimethyl); LCDSEAHVCFEGLDSDPTGTAYGASIP Sulfite oxidase, Q8R086 C2(Carbamidomethyl); 1 3237.476 4.88 LAR mitochondrial C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LCDSEAHVCFEGLDSDPTGTAYGASIP Sulfite oxidase, Q8R086 C2(Carbamidomethyl); 1 3245.518 4.71 LAR mitochondrial C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LCDVLAQAGHRLCDSEAHVCFEGLDS Sulfite oxidase, C2(Carbamidomethyl); Q8R086 1 4466.136 3.74 DPTGTAYGASIPLAR mitochondrial C13(Carbamidomethyl); C20(Carbamidomethyl)

NADH dehydrogenase N-Term(Dimethyl); LCEAICPAQAITIEAEPR Q8K3J1 [ubiquinone] iron-sulfur C2(Carbamidomethyl); 3 2070.038 3.30 protein 8, mitochondrial C6(Carbamidomethyl)

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); LCEAICPAQAITIEAEPR Q8K3J1 [ubiquinone] iron-sulfur C2(Carbamidomethyl); 1 2078.082 4.32 protein 8, mitochondrial C6(Carbamidomethyl)

N-Term(Dimethyl:2H(6)13C(2)); LCEEHGIIRENIIDLTNVNR Q80YX8 Major urinary protein 26 1 2444.309 2.62 C2(Carbamidomethyl) N-Term(Dimethyl); LCENIAGHLKDAQLFIQK P24270 Catalase C2(Carbamidomethyl); K10(Dimethyl); 1 2182.208 3.08 K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); LCENIAGHLKDAQLFIQK P24270 Catalase 1 2206.343 2.71 K10(HeavyDimethyl); K18(HeavyDimethyl) C2(Carbamidomethyl); Uncharacterized protein C13(Carbamidomethyl); LCEPQWFYEETECSDDIEVLTLKK Q9D2X8 1 3104.540 2.85 C8orf76 homolog K23(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl); LCLISTFLEDGIR E0CXD9 Surfeit locus protein 4 1 1564.848 2.16 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LCLISTFLEDGIR E0CXD9 Surfeit locus protein 4 2 1572.892 2.06 C2(Carbamidomethyl) 4-hydroxy-2- N-Term(Dimethyl); LCLTGQWEAAQELQHR E9Q1R2 oxoglutarate aldolase, 5 1967.973 3.05 C2(Carbamidomethyl) mitochondrial N-Term(Dimethyl); C2(Carbamidomethyl); LCNPCSEDDWSNAEKNKCVPK E9Q107 Protein Vmn2r3 C5(Carbamidomethyl); K15(Dimethyl); 1 2663.238 2.71 K17(Dimethyl); C18(Carbamidomethyl); K21(Dimethyl) Peroxisomal bifunctional N-Term(Dimethyl); LCNPPVNAISPTVITEVR Q9DBM2 9 2008.087 4.21 enzyme C2(Carbamidomethyl) Peroxisomal bifunctional N-Term(Dimethyl:2H(6)13C(2)); LCNPPVNAISPTVITEVR Q9DBM2 7 2016.137 5.42 enzyme C2(Carbamidomethyl) Hermansky-Pudlak LCPPEVAPHELLLLLRTHLPDDEGTTPF N-Term(Dimethyl); Q8BLY7 syndrome 6 protein 1 4721.484 2.97 PEPGAEPPLTVGLVR C2(Carbamidomethyl) homolog N-Term(Dimethyl); LCPPVPGQALMGMVVSPPTPSEPSFKQ Alanine Q8QZR5 C2(Carbamidomethyl); K26(Dimethyl); 1 4619.430 3.21 FQAERQEVLAELAAK aminotransferase 1 K42(Dimethyl) LCPPVSGQAAMDIVVNPPEPGEESFEQ Alanine N-Term(Dimethyl:2H(6)13C(2)); Q8BGT5 1 3323.617 2.62 FSR aminotransferase 2 C2(Carbamidomethyl) N-Term(Dimethyl); C2(Carbamidomethyl); LCQLCPGCGCSSTQPFFGYVGAFK Q921I1 Serotransferrin C5(Carbamidomethyl); 2 2797.265 4.23 C8(Carbamidomethyl); C10(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); C5(Carbamidomethyl); LCQLCPGCGCSSTQPFFGYVGAFK Q921I1 Serotransferrin 4 2813.362 4.26 C8(Carbamidomethyl); C10(Carbamidomethyl); K24(HeavyDimethyl) CUB and sushi domain- N-Term(Dimethyl:2H(6)13C(2)); LCQTDGTWSGSSPHCIEPTR F6TRD7 containing protein 3 C2(Carbamidomethyl); 1 2325.074 2.25 (Fragment) C15(Carbamidomethyl) N-Term(Dimethyl); LCRYLSLDDTDYCFPSLLVNENLNSNL Isoform 2 of HHIP-like Q14DK5-2 C2(Carbamidomethyl); 1 3489.721 3.27 GR protein 1 C13(Carbamidomethyl) N-Term(Dimethyl); LCSNTQMLWDQTSSEIR E9Q9P8 Uncharacterized protein 1 2097.001 3.20 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LCSNTQMLWDQTSSEIR E9Q9P8 Uncharacterized protein 1 2121.030 2.33 C2(Carbamidomethyl); M7(Oxidation) LCTGTLPRVFTR P43430 Mast cell protease 8 C2(Carbamidomethyl) 1 1420.792 1.95 Cytochrome b-c1 N-Term(Dimethyl); LCTSATESEVTR Q9CZ13 complex subunit 1, 7 1381.658 2.99 C2(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); LCTSATESEVTR Q9CZ13 complex subunit 1, 6 1389.703 3.52 C2(Carbamidomethyl) mitochondrial Actin, gamma-enteric N-Term(Dimethyl); LCYVALDFENEMATAASSSSLEK D3YZY0 smooth muscle C2(Carbamidomethyl); M12(Oxidation); 1 2608.252 4.44 (Fragment) K23(Dimethyl) Actin, gamma-enteric N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFENEMATAASSSSLEK D3YZY0 smooth muscle C2(Carbamidomethyl); M12(Oxidation); 1 2624.321 4.50 (Fragment) K23(HeavyDimethyl) Actin, gamma-enteric N-Term(Dimethyl); LCYVALDFENEMATAASSSSLEKSYEL D3YZY0 smooth muscle C2(Carbamidomethyl); M12(Oxidation); 1 4380.077 3.02 PDGQVITIGNER (Fragment) K23(Dimethyl) Actin, gamma-enteric N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFENEMATAASSSSLEKSYEL D3YZY0 smooth muscle C2(Carbamidomethyl); 1 4380.174 5.07 PDGQVITIGNER (Fragment) K23(HeavyDimethyl) Actin, gamma-enteric N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFENEMATAASSSSLEKSYEL D3YZY0 smooth muscle C2(Carbamidomethyl); M12(Oxidation); 1 4396.134 3.02 PDGQVITIGNER (Fragment) K23(HeavyDimethyl) Actin, gamma-enteric N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFENEMATAASSSSLEKSYEL D3YZY0 smooth muscle C2(Carbamidomethyl); M12(Oxidation); 1 4699.405 3.66 PDGQVITIGNERFR (Fragment) K23(HeavyDimethyl) N-Term(Dimethyl); LCYVALDFEQEMATAASSSSLEK E9Q1F2 Actin, cytoplasmic 1 13 2606.242 5.91 C2(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFEQEMATAASSSSLEK E9Q1F2 Actin, cytoplasmic 1 C2(Carbamidomethyl); 4 2622.341 5.73 K23(HeavyDimethyl) LCYVALDFEQEMATAASSSSLEKSYEL N-Term(Dimethyl); E9Q1F2 Actin, cytoplasmic 1 2 4378.132 6.12 PDGQVITIGNER C2(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LCYVALDFEQEMATAASSSSLEKSYEL E9Q1F2 Actin, cytoplasmic 1 C2(Carbamidomethyl); 3 4394.228 5.27 PDGQVITIGNER K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LCYVGYNIEQEQK P61161 Actin-related protein 2 C2(Carbamidomethyl); 2 1715.923 2.11 K13(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); WW domain-binding LDEMEFNPVQQPQLNEKVLK Q923D5 K17(HeavyDimethyl); 1 2507.461 2.55 protein 11 K20(HeavyDimethyl) Intraflagellar transport LDETMDSIGEDDPFTAK Q6NWV3 M5(Oxidation); K17(HeavyDimethyl) 1 1935.913 2.27 protein 122 homolog Rab9 effector protein N-Term(Dimethyl); M5(Oxidation); LDHSMCVIPWPVMSTSENK A2AUF7 1 2303.096 2.61 with kelch motifs C6(Carbamidomethyl); K19(Dimethyl) DNA replication LDNLTLMEISSSGAFLTQALNHMYK Q9D600 complex GINS protein M23(Oxidation); K25(Dimethyl) 1 2841.380 2.88 PSF2 Prostaglandin F2 LDRDSLVHSSPHVALSHVDTRSYHLLV Q9WV91 receptor negative 1 3209.646 3.20 R regulator N-Term(Dimethyl); 40S ribosomal protein LDVGNFSWGSECCTR P62242 C12(Carbamidomethyl); 6 1815.773 3.73 S8 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein LDVGNFSWGSECCTR P62242 C12(Carbamidomethyl); 1 1823.814 2.71 S8 C13(Carbamidomethyl) Carbohydrate LEADANQVLEWVR A2AQV2 N-Term(Dimethyl:2H(6)13C(2)) 2 1578.878 2.24 sulfotransferase 14 Protein Sptbn5 N-Term(Dimethyl:2H(6)13C(2)); LEALRDLWEKLR F6TMY4 1 1614.022 2.11 (Fragment) K10(HeavyDimethyl) 5-hydroxyisourate N-Term(Dimethyl); LEAPCQQWMELR Q9CRB3 1 1588.758 2.34 hydrolase C5(Carbamidomethyl) 5-hydroxyisourate N-Term(Dimethyl); LEAPCQQWMELR Q9CRB3 1 1604.751 2.41 hydrolase C5(Carbamidomethyl); M9(Oxidation) 5-hydroxyisourate N-Term(Dimethyl:2H(6)13C(2)); LEAPCQQWMELR Q9CRB3 2 1596.808 2.32 hydrolase C5(Carbamidomethyl) LECGGGRWGNKGFFVQPTVFSNVTDE N-Term(Dimethyl); P24549 Retinal dehydrogenase 1 4 3244.564 5.12 MR C3(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LECGGGRWGNKGFFVQPTVFSNVTDE P24549 Retinal dehydrogenase 1 C3(Carbamidomethyl); 3 3260.645 4.42 MR K11(HeavyDimethyl) CBP80/20-dependent LEDGPGDTGHSGLEPPCSPDTLTPAAS N-Term(Dimethyl); Q6PEE2 translation initiation 1 4434.192 3.33 ERPTPQLPGGPEAEIK C17(Carbamidomethyl); K43(Dimethyl) factor LEEEESVLVEAMCPPVRLPLPGGPAPG Q6ZPS2 Carnosine synthase 1 M12(Oxidation); C13(Carbamidomethyl) 1 3524.801 2.98 PELAVR Isoform 2 of Transient receptor potential cation LEEINERENFMKTSLQTVDLR Q2TV84-2 N-Term(Dimethyl); K12(Dimethyl) 1 2621.362 2.74 channel subfamily M member 1 5-oxoprolinase N-Term(Dimethyl); LEEQCVDALQAQGFSR E9Q484 1 1878.893 2.30 (Fragment) C5(Carbamidomethyl) LEFFSHMVARNTNLCSTCVLSIHHFVT M7(Oxidation); C15(Carbamidomethyl); K7N6J6 Taste receptor type 2 2 3931.047 3.18 LVLVNR C18(Carbamidomethyl) N-Term(Dimethyl); K15(Dimethyl); LEFGSFWELIGEAAKSVKMERPVTR E9Q2K8 Protein S100-A14 1 2964.615 2.50 K18(Dimethyl) Isoform 3 of Putative LEGDATLQGVTHIIVDEVHERTEESDF N-Term(Dimethyl:2H(6)13C(2)); Q6P5D3-3 ATP-dependent RNA 1 4533.435 3.46 LLLVLKDIVMQR K33(HeavyDimethyl) helicase DHX57 N-Term(Dimethyl); Isoform 2 of Ig gamma- LEPSGPISTINPCPPCK P01867-2 C13(Carbamidomethyl); 1 1922.969 2.47 2B chain C region C16(Carbamidomethyl); K17(Dimethyl) LETTLSVCAEEPDHSQLFTHLGRMALE TNFAIP3-interacting D3Z410 C8(Carbamidomethyl) 1 3501.660 2.69 FNR protein 1 (Fragment) LEVTFNLRDPVTR M0QW64 Protein Kcnh6 N-Term(Dimethyl:2H(6)13C(2)) 2 1595.910 2.42 Bifunctional 3'- N-Term(Dimethyl:2H(6)13C(2)); phosphoadenosine 5'- LFADAGLVCITSFISPFAK O88428 C9(Carbamidomethyl); 2 2129.223 3.07 phosphosulfate synthase K19(HeavyDimethyl) 2 Bifunctional 3'- phosphoadenosine 5'- N-Term(Dimethyl); LFADAGLVCITSFISPFAKDRENAR O88428 1 2854.505 2.82 phosphosulfate synthase C9(Carbamidomethyl); K19(Dimethyl) 2 Bifunctional 3'- N-Term(Dimethyl:2H(6)13C(2)); phosphoadenosine 5'- LFADAGLVCITSFISPFAKDRENAR O88428 C9(Carbamidomethyl); 1 2870.586 3.29 phosphosulfate synthase K19(HeavyDimethyl) 2 LFCSTSGFSVGIVFLQFAYDATFMSIMV N-Term(Dimethyl:2H(6)13C(2)); K9J7F4 Protein Gm5725 1 4925.572 3.92 WTSVSMVLLLRRHR C3(Carbamidomethyl); M27(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); LFGGQIMGQALVAAAKSVSEDVHVHS Acyl-coenzyme A Q8BZR4 K16(HeavyDimethyl); 1 3698.984 3.23 LHCYFVR thioesterase 8 C29(Carbamidomethyl) Ornithine N-Term(Dimethyl); K6(Dimethyl); LFNYNKVLPMNTGVEAGETACK P29758 aminotransferase, 1 2540.279 4.47 C21(Carbamidomethyl); K22(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Ornithine K6(HeavyDimethyl); LFNYNKVLPMNTGVEAGETACK P29758 aminotransferase, 2 2564.424 3.87 C21(Carbamidomethyl); mitochondrial K22(HeavyDimethyl) LFPSGLDQKDMHGDSEYNIMFGPDICG N-Term(Dimethyl); K9(Dimethyl); P14211 Calreticulin 3 3510.655 3.98 PGTK C26(Carbamidomethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LFPSGLDQKDMHGDSEYNIMFGPDICG K9(HeavyDimethyl); P14211 Calreticulin 1 3534.762 3.71 PGTK C26(Carbamidomethyl); K31(HeavyDimethyl) C9(Carbamidomethyl); LFSSQEEQCRKTSLHPLR B2KG20 Protein Klri1 1 2252.193 2.22 K11(HeavyDimethyl) C4(Carbamidomethyl); K9(HeavyDimethyl); LFTCSSSLKVYHENCTGERIHK S4R2N6 Protein Gm26919 1 2738.441 2.63 C15(Carbamidomethyl); K22(HeavyDimethyl) Isoform 2 of Nitrilase N-Term(Dimethyl); LGACLAFLPEAFDFIAR Q8VDK1-2 1 1939.021 2.27 homolog 1 C4(Carbamidomethyl) N-Term(Dimethyl); Adrenodoxin, LGCQVCLTK P46656 C3(Carbamidomethyl); 1 1134.602 2.21 mitochondrial C6(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adrenodoxin, C3(Carbamidomethyl); LGCQVCLTK P46656 2 1150.686 2.63 mitochondrial C6(Carbamidomethyl); K9(HeavyDimethyl) N-Term(Dimethyl); Ubiquitin-like modifier- LGCYFCNDVVAPGDSTR S4R2D5 C3(Carbamidomethyl); 1 1958.883 2.74 activating enzyme ATG7 C6(Carbamidomethyl) LGDAVEQGVINNSVLGYFIGRIYLYLT K28(HeavyDimethyl); Q9CZD3 Glycine--tRNA ligase 1 3884.183 3.15 KVGISPDK K35(HeavyDimethyl) N-Term(Dimethyl); Isocitrate dehydrogenase LGDGLFLQCCEEVAELYPK Q91VA7 C9(Carbamidomethyl); 2 2297.122 3.69 3 (NAD+) beta C10(Carbamidomethyl); K19(Dimethyl)

Isocitrate dehydrogenase N-Term(Dimethyl); LGDGLFLQCCR P70404 [NAD] subunit gamma C9(Carbamidomethyl); 1 1366.661 2.18 1, mitochondrial C10(Carbamidomethyl)

Isocitrate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); LGDGLFLQCCR P70404 [NAD] subunit gamma C9(Carbamidomethyl); 1 1374.712 2.20 1, mitochondrial C10(Carbamidomethyl) Transitional N-Term(Dimethyl); LGDVISIQPCPDVK Q01853 endoplasmic reticulum 5 1596.861 2.63 C10(Carbamidomethyl); K14(Dimethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); LGDVISIQPCPDVK Q01853 endoplasmic reticulum C10(Carbamidomethyl); 5 1612.953 3.12 ATPase K14(HeavyDimethyl) Isoform 2 of G patch LGELWEEMALSPR Q6PE65-2 domain-containing N-Term(Dimethyl:2H(6)13C(2)) 1 1566.837 2.07 protein 2-like 3-hydroxyacyl-CoA N-Term(Dimethyl); LGESCIFAPANVTSEK O08756 6 1778.901 4.00 dehydrogenase type-2 C5(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-hydroxyacyl-CoA LGESCIFAPANVTSEK O08756 C5(Carbamidomethyl); 5 1794.982 3.74 dehydrogenase type-2 K16(HeavyDimethyl) N-Term(Dimethyl); 3-hydroxyacyl-CoA LGESCIFAPANVTSEKEIQAALTLAKEK O08756 C5(Carbamidomethyl); K16(Dimethyl); 1 3130.728 2.88 dehydrogenase type-2 K26(Dimethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); 3-hydroxyacyl-CoA LGESCIFAPANVTSEKEIQAALTLAKEK O08756 K16(HeavyDimethyl); 1 3162.884 3.10 dehydrogenase type-2 K26(HeavyDimethyl); K28(HeavyDimethyl) Electron transfer N-Term(Dimethyl); LGGEVSCLVAGTK Q99LC5 flavoprotein subunit 2 1346.734 2.65 C7(Carbamidomethyl); K13(Dimethyl) alpha, mitochondrial Electron transfer N-Term(Dimethyl:2H(6)13C(2)); LGGEVSCLVAGTK Q99LC5 flavoprotein subunit C7(Carbamidomethyl); 1 1362.820 2.24 alpha, mitochondrial K13(HeavyDimethyl)

N-Term(Dimethyl); Electron transfer C7(Carbamidomethyl); K13(Dimethyl); LGGEVSCLVAGTKCDKVVQDLCK Q99LC5 flavoprotein subunit 4 2648.376 4.33 C14(Carbamidomethyl); K16(Dimethyl); alpha, mitochondrial C22(Carbamidomethyl); K23(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); Electron transfer K13(HeavyDimethyl); LGGEVSCLVAGTKCDKVVQDLCK Q99LC5 flavoprotein subunit C14(Carbamidomethyl); 3 2680.546 4.03 alpha, mitochondrial K16(HeavyDimethyl); C22(Carbamidomethyl); K23(HeavyDimethyl) LGGLTQAPGNPVLAVQINQDKNFAFLE Splicing factor U2AF 65 Q3KQM4 N-Term(Dimethyl); K21(Dimethyl) 1 3213.702 2.96 FR kDa subunit LGGNPEKINPVCPADLVIDHSIQVDFN Cytoplasmic aconitate N-Term(Dimethyl); K7(Dimethyl); P28271 2 3173.643 3.42 R hydratase C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LGGNPEKINPVCPADLVIDHSIQVDFN Cytoplasmic aconitate P28271 K7(HeavyDimethyl); 2 3189.733 3.54 R hydratase C12(Carbamidomethyl) T-complex protein 1 N-Term(Dimethyl); LGGTIDDCELVEGLVLTQK G5E839 1 2116.133 3.44 subunit delta C8(Carbamidomethyl); K19(Dimethyl) M6(Oxidation); C8(Carbamidomethyl); HAUS augmin-like LGHELMFCAPDDQDLLMGRECPQK Q8BKT8 C21(Carbamidomethyl); 1 2912.364 2.26 complex subunit 7 K24(HeavyDimethyl) Neurobeachin-like N-Term(Dimethyl); M7(Oxidation); LGHIQYMSSMVREHRQK F6VTL9 1 2188.083 2.57 protein 2 (Fragment) M10(Oxidation); K17(Dimethyl) Peroxisomal N-Term(Dimethyl); LGILGLCNTLAIEGR P51660 multifunctional enzyme 7 1627.918 3.33 C7(Carbamidomethyl) type 2 Peroxisomal N-Term(Dimethyl:2H(6)13C(2)); LGILGLCNTLAIEGR P51660 multifunctional enzyme 7 1635.962 3.65 C7(Carbamidomethyl) type 2 N-Term(Dimethyl:2H(6)13C(2)); K21(HeavyDimethyl); Glycerol-3-phosphate LGIPMSVLMGANIASEVAEEKFCETTI C23(Carbamidomethyl); E0CXN5 dehydrogenase 1 4350.430 3.48 GCKDPAQGQLLK C29(Carbamidomethyl); [NAD(+)], cytoplasmic K30(HeavyDimethyl); K39(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LGKPEDCAGIVSFLCSEDASYINGETV Dehydrogenase/reductas K3(HeavyDimethyl); Q99LB2 2 3927.041 5.18 VVGGGTPSRL e SDR family member 4 C7(Carbamidomethyl); C15(Carbamidomethyl) N(G),N(G)- N-Term(Dimethyl); LGLQVVQLPADESLPDCVFVEDVAVV dimethylarginine Q9CWS0 C17(Carbamidomethyl); 2 4478.304 3.35 CEETALITRPGAPSR dimethylaminohydrolase C27(Carbamidomethyl) 1 N(G),N(G)- N-Term(Dimethyl:2H(6)13C(2)); LGLQVVQLPADESLPDCVFVEDVAVV dimethylarginine Q9CWS0 C17(Carbamidomethyl); 1 4486.358 3.60 CEETALITRPGAPSR dimethylaminohydrolase C27(Carbamidomethyl) 1 N-Term(Dimethyl); LGMLSPDGTCR P19096 Fatty acid synthase 5 1234.589 2.88 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LGMLSPDGTCR P19096 Fatty acid synthase 5 1242.632 2.74 C10(Carbamidomethyl) LGNTQGIISAFSTIMSVHRGEVPCTVTT ATP synthase subunit O, N-Term(Dimethyl); Q9DB20 1 4371.275 4.48 ASPLDDAVLSELK mitochondrial C24(Carbamidomethyl); K41(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LGNTQGIISAFSTIMSVHRGEVPCTVTT ATP synthase subunit O, Q9DB20 C24(Carbamidomethyl); 1 4387.383 3.45 ASPLDDAVLSELK mitochondrial K41(HeavyDimethyl) N-Term(Dimethyl); LGNTQGIISAFSTIMSVHRGEVPCTVTT ATP synthase subunit O, Q9DB20 C24(Carbamidomethyl); K41(Dimethyl); 3 4840.614 4.64 ASPLDDAVLSELKTVLK mitochondrial K45(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LGNTQGIISAFSTIMSVHRGEVPCTVTT ATP synthase subunit O, C24(Carbamidomethyl); Q9DB20 1 4864.717 3.58 ASPLDDAVLSELKTVLK mitochondrial K41(HeavyDimethyl); K45(HeavyDimethyl) Aldehyde N-Term(Dimethyl); LGPALSCGNTVVVKPAEQTPLTALHM O35945 dehydrogenase, cytosolic C7(Carbamidomethyl); K14(Dimethyl); 3 3300.839 3.66 ASLIK 1 K31(Dimethyl) N-Term(Dimethyl); LGPNYLQIPVNCPYR P24270 Catalase 17 1831.946 5.05 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LGPNYLQIPVNCPYR P24270 Catalase 14 1839.999 5.44 C12(Carbamidomethyl) N-Term(Dimethyl); LGSPVPSCSVVGTISSYYVQR Q3TNA1 Xylulose kinase 2 2284.149 3.11 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LGSPVPSCSVVGTISSYYVQR Q3TNA1 Xylulose kinase 1 2292.217 2.67 C8(Carbamidomethyl) N-Term(Dimethyl); LGTDESCFNMILATR Q07076 Annexin A7 3 1755.835 3.04 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LGTDESCFNMILATR Q07076 Annexin A7 1 1763.898 2.48 C7(Carbamidomethyl) Succinate-semialdehyde N-Term(Dimethyl); LGTVADCGVPEAR Q8BWF0 dehydrogenase, 11 1372.685 3.70 C7(Carbamidomethyl) mitochondrial

Succinate-semialdehyde N-Term(Dimethyl:2H(6)13C(2)); LGTVADCGVPEAR Q8BWF0 dehydrogenase, 7 1380.728 2.94 C7(Carbamidomethyl) mitochondrial

Isoform 2 of 2- oxoisovalerate N-Term(Dimethyl:2H(6)13C(2)); LGVSCEVIDLR Q6P3A8-2 2 1296.732 2.26 dehydrogenase subunit C5(Carbamidomethyl) beta, mitochondrial POU domain, class 4, LGVTQADVGAALANLK Q63955 N-Term(Dimethyl); K16(Dimethyl) 1 1596.942 2.20 transcription factor 3 LHLDEDYPCSLVGNWNTWYGEQDQA Protein NipSnap N-Term(Dimethyl); Q5SVG6 1 3729.738 3.94 VHLWR homolog 1 (Fragment) C9(Carbamidomethyl) Isoform 2 of LHLLDRLLAFLYSGGHRVLLFSQMTH Chromodomain-helicase- Q9CXF7-2 M24(Oxidation); M27(Oxidation) 2 4626.362 3.79 MLDILQDYMDYR DNA-binding protein 1- like Transcription factor LHMAQHYQSGPVPGTAKYGTLPLSHM P48432 K17(HeavyDimethyl) 1 2857.483 2.68 SOX-2 Probable D-lactate LHPAPEATVAATCAFPSVQAAVDSTV N-Term(Dimethyl); Q7TNG8 dehydrogenase, 1 3784.996 3.48 QILQAAVPVAR C13(Carbamidomethyl) mitochondrial Probable D-lactate LHPAPEATVAATCAFPSVQAAVDSTV N-Term(Dimethyl:2H(6)13C(2)); Q7TNG8 dehydrogenase, 1 3793.067 3.16 QILQAAVPVAR C13(Carbamidomethyl) mitochondrial N-Term(Dimethyl); Isoform 2 of LHTGERPFVCNWFFCGK Q9D2H6-2 C10(Carbamidomethyl); 1 2211.095 2.59 Transcription factor Sp2 C15(Carbamidomethyl); K17(Dimethyl) LHVCVHNGLGFVQRPQVVVLVPEMD N-Term(Dimethyl:2H(6)13C(2)); P59240 Nephrocystin-4 1 4054.167 3.00 VALTRSASFSR C4(Carbamidomethyl) N-Term(Dimethyl); 40S ribosomal protein LHYCVSCAIHSK P62855 C4(Carbamidomethyl); 1 1530.751 2.24 S26 C7(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein C4(Carbamidomethyl); LHYCVSCAIHSK P62855 2 1546.840 2.66 S26 C7(Carbamidomethyl); K12(HeavyDimethyl) Chromobox protein K8(HeavyDimethyl); M20(Oxidation); LIAAFEQKPGPRRRPSASVMCISLSSR D3Z329 1 3066.711 2.92 homolog 6 (Fragment) C21(Carbamidomethyl) Leucine-rich PPR motif- N-Term(Dimethyl); LIAAYCNVGDIEGASK Q6PB66 containing protein, 7 1736.883 4.38 C6(Carbamidomethyl); K16(Dimethyl) mitochondrial Leucine-rich PPR motif- N-Term(Dimethyl:2H(6)13C(2)); LIAAYCNVGDIEGASK Q6PB66 containing protein, C6(Carbamidomethyl); 5 1752.972 4.13 mitochondrial K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); 14-3-3 protein epsilon LICCDILDVLDKHLIPAANTGESK F6WA09 C4(Carbamidomethyl); 1 2803.617 2.67 (Fragment) K12(HeavyDimethyl); K24(HeavyDimethyl) N-Term(Dimethyl); LICEATNFTPKPITVSWLK P01872 Ig mu chain C region C3(Carbamidomethyl); K11(Dimethyl); 1 2302.289 3.44 K19(Dimethyl) Isocitrate dehydrogenase N-Term(Dimethyl); K11(Dimethyl); LIDDMVAQAMKSEGGFIWACK O88844 5 2454.191 3.05 [NADP] cytoplasmic C20(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase K11(HeavyDimethyl); LIDDMVAQAMKSEGGFIWACK O88844 1 2478.339 2.74 [NADP] cytoplasmic C20(Carbamidomethyl); K21(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl); K6(Dimethyl); [ubiquinone] C10(Carbamidomethyl); LIEFYKHESCGQCTPCR D3Z1U9 1 2241.023 2.48 flavoprotein 1, C13(Carbamidomethyl); mitochondrial C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NADH dehydrogenase K6(HeavyDimethyl); [ubiquinone] LIEFYKHESCGQCTPCR D3Z1U9 C10(Carbamidomethyl); 1 2257.116 2.77 flavoprotein 1, C13(Carbamidomethyl); mitochondrial C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- LIENTDAACK Q9DCM2 C9(Carbamidomethyl); 1 1206.693 2.21 transferase kappa 1 K10(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- C9(Carbamidomethyl); LIENTDAACKYGAFGLPTTVAHVDGK Q9DCM2 1 2856.596 2.58 transferase kappa 1 K10(HeavyDimethyl); K26(HeavyDimethyl) Staphylococcal nuclease N-Term(Dimethyl); K4(Dimethyl); LIGKEVCFTIENKTPQGR Q3TJ56 domain-containing 2 2174.203 2.85 C7(Carbamidomethyl); K13(Dimethyl) protein 1 Succinyl-CoA ligase N-Term(Dimethyl); [ADP/GDP-forming] LIGPNCPGVINPGECK Q9WUM5 C6(Carbamidomethyl); 19 1780.904 5.03 subunit alpha, C15(Carbamidomethyl); K16(Dimethyl) mitochondrial Succinyl-CoA ligase N-Term(Dimethyl:2H(6)13C(2)); [ADP/GDP-forming] C6(Carbamidomethyl); LIGPNCPGVINPGECK Q9WUM5 19 1796.989 5.06 subunit alpha, C15(Carbamidomethyl); mitochondrial K16(HeavyDimethyl) NADPH--cytochrome LIHEGGAHIYVCGDAR P37040 C12(Carbamidomethyl) 2 1767.858 2.31 P450 reductase NADPH--cytochrome N-Term(Dimethyl); LIHEGGAHIYVCGDAR P37040 1 1795.883 3.62 P450 reductase C12(Carbamidomethyl) NADPH--cytochrome N-Term(Dimethyl:2H(6)13C(2)); LIHEGGAHIYVCGDAR P37040 7 1803.925 3.51 P450 reductase C12(Carbamidomethyl) Serine N-Term(Dimethyl); LIIAGTSCYSR G3UZ26 hydroxymethyltransferas 4 1268.662 2.86 C8(Carbamidomethyl) e (Fragment) Serine N-Term(Dimethyl:2H(6)13C(2)); LIIAGTSCYSR G3UZ26 hydroxymethyltransferas 5 1276.708 3.07 C8(Carbamidomethyl) e (Fragment) Sodium/potassium- N-Term(Dimethyl); LIIVEGCQR Q8VDN2 transporting ATPase 10 1115.620 2.42 C7(Carbamidomethyl) subunit alpha-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); LIIVEGCQR Q8VDN2 transporting ATPase 1 1123.668 2.04 C7(Carbamidomethyl) subunit alpha-1 Isoform 2 of Cytosol N-Term(Dimethyl); LILADALCYAHTFNPK Q9CPY7-2 3 1903.020 2.79 aminopeptidase C8(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol LILADALCYAHTFNPK Q9CPY7-2 C8(Carbamidomethyl); 2 1919.103 4.24 aminopeptidase K16(HeavyDimethyl) Mitochondrial glutamate N-Term(Dimethyl); LINGGIAGLIGVTCVFPIDLAK E9Q6M6 1 2297.333 2.66 carrier 1 C14(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Mitochondrial glutamate LINGGIAGLIGVTCVFPIDLAK E9Q6M6 C14(Carbamidomethyl); 1 2313.437 3.04 carrier 1 K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein LIPDGCGVK I7HLV2 C6(Carbamidomethyl); 1 1030.653 1.95 L10 (Fragment) K9(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); K8(Dimethyl); LIPDSIGKDIEKACQSIYPLHDVFVR D3Z6C3 1 3097.683 2.93 S3a K12(Dimethyl); C14(Carbamidomethyl) N-Term(Dimethyl); LIPPFHAASAQLTSLVDADARAFAACL Formimidoyltransferase- Q91XD4 C26(Carbamidomethyl); K31(Dimethyl); 1 3690.063 4.08 EAIKLPK cyclodeaminase K34(Dimethyl) 3- N-Term(Dimethyl); LISETTAICKPEQVAK Q6GV12 ketodihydrosphingosine C9(Carbamidomethyl); K10(Dimethyl); 1 1872.045 2.41 reductase K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3- C9(Carbamidomethyl); LISETTAICKPEQVAK Q6GV12 ketodihydrosphingosine 2 1896.185 2.37 K10(HeavyDimethyl); reductase K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Eukaryotic LISKPVASDSTYFAWCPDGEHILTATC K4(HeavyDimethyl); Q8BJW6-2 translation initiation 2 3435.799 3.72 APR C16(Carbamidomethyl); factor 2A C27(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); K9(Dimethyl); LITEDVQGKNCLTNFHGMDLTR D3Z6C3 3 2618.303 3.54 S3a C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein LITEDVQGKNCLTNFHGMDLTR D3Z6C3 K9(HeavyDimethyl); 1 2634.397 2.75 S3a C11(Carbamidomethyl) N-Term(Dimethyl); K10(Dimethyl); LITLEEEMTKYKPESDELTAEKITEFCH Protein disulfide- P09103 K12(Dimethyl); K22(Dimethyl); 1 3652.864 3.06 R isomerase C27(Carbamidomethyl) Estradiol 17 beta- N-Term(Dimethyl); LIYDAVDICDTWEAMEK D3Z3P8 dehydrogenase 5 8 2128.008 4.59 C9(Carbamidomethyl); K17(Dimethyl) (Fragment) Estradiol 17 beta- N-Term(Dimethyl:2H(6)13C(2)); LIYDAVDICDTWEAMEK D3Z3P8 dehydrogenase 5 C9(Carbamidomethyl); 2 2144.102 3.51 (Fragment) K17(HeavyDimethyl) K2(Dimethyl); C5(Carbamidomethyl); LKASCPSMAGIIEEK F6W8R9 Nesprin-2 (Fragment) 1 1689.903 2.63 K15(Dimethyl) Betaine--homocysteine S-N-Term(Dimethyl); K2(Dimethyl); LKAYLMSQPLAYHTPDCGK O35490 7 2277.174 5.54 methyltransferase 1 C17(Carbamidomethyl); K19(Dimethyl)

N-Term(Dimethyl); K2(Dimethyl); Betaine--homocysteine S- LKAYLMSQPLAYHTPDCGK O35490 M6(Oxidation); C17(Carbamidomethyl); 7 2293.165 4.01 methyltransferase 1 K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-K2(HeavyDimethyl); LKAYLMSQPLAYHTPDCGK O35490 4 2301.308 5.33 methyltransferase 1 C17(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-K2(HeavyDimethyl); M6(Oxidation); LKAYLMSQPLAYHTPDCGK O35490 4 2317.302 4.03 methyltransferase 1 C17(Carbamidomethyl); K19(HeavyDimethyl) LKAYLMSQPLAYHTPDCGKQGFIDLPE Betaine--homocysteine S-N-Term(Dimethyl); K2(Dimethyl); O35490 10 4120.117 5.35 FPFGLEPR methyltransferase 1 C17(Carbamidomethyl); K19(Dimethyl)

N-Term(Dimethyl); K2(Dimethyl); LKAYLMSQPLAYHTPDCGKQGFIDLPE Betaine--homocysteine S- O35490 M6(Oxidation); C17(Carbamidomethyl); 2 4136.105 3.24 FPFGLEPR methyltransferase 1 K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LKAYLMSQPLAYHTPDCGKQGFIDLPE Betaine--homocysteine S-K2(HeavyDimethyl); O35490 6 4144.238 5.83 FPFGLEPR methyltransferase 1 C17(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LKAYLMSQPLAYHTPDCGKQGFIDLPE Betaine--homocysteine S-K2(HeavyDimethyl); M6(Oxidation); O35490 1 4160.255 3.56 FPFGLEPR methyltransferase 1 C17(Carbamidomethyl); K19(HeavyDimethyl) Dihydrolipoyllysine- residue succinyltransferase N-Term(Dimethyl:2H(6)13C(2)); LKEAQNTCAMLTTFNEVDMSNIQEMR Q9D2G2 component of 2- K2(HeavyDimethyl); 2 3146.565 3.30 oxoglutarate C8(Carbamidomethyl) dehydrogenase complex, mitochondrial Carboxymethylenebuten N-Term(Dimethyl); K2(Dimethyl); LKEHCIVNYQVK Q8R1G2 7 1614.902 2.96 olidase homolog C5(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carboxymethylenebuten K2(HeavyDimethyl); LKEHCIVNYQVK Q8R1G2 2 1639.034 3.60 olidase homolog C5(Carbamidomethyl); K12(HeavyDimethyl) WD repeat-containing N-Term(Dimethyl:2H(6)13C(2)); LKFWDMTQLRTVVVDDYR Q9CX97 1 2373.322 2.46 protein 55 K2(HeavyDimethyl); M6(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Protein disulfide- K9(HeavyDimethyl); LKGIVPLAKVDCTANTNTCNK P27773 1 2461.501 2.62 isomerase A3 C12(Carbamidomethyl); C19(Carbamidomethyl); K21(HeavyDimethyl) 3-oxoacyl-[acyl-carrier- N-Term(Dimethyl:2H(6)13C(2)); LKGPNHSVSTACTTGAHAVGDSFR Q9D404 protein] synthase, K2(HeavyDimethyl); 2 2542.330 3.18 mitochondrial C12(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); LKLFIYQMMESHR G3UXT0 Protein Cyp2j12 1 1767.939 2.44 M9(Oxidation)

K2(Dimethyl); C8(Carbamidomethyl); LKLLGQSCAFLFTWMESCKEGIGMLV Coiled-coil domain- M15(Oxidation); E9Q1U1 1 3790.926 2.99 CTGEPK containing protein 171 C18(Carbamidomethyl); K19(Dimethyl); C27(Carbamidomethyl); K32(Dimethyl)

Glutathione S- N-Term(Dimethyl); K2(Dimethyl); LKLSVQCLLH Q99L20 2 1266.761 2.48 transferase theta 3 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- LKLSVQCLLH Q99L20 K2(HeavyDimethyl); 1 1282.853 2.87 transferase theta 3 C7(Carbamidomethyl) Isoform 2 of Obg-like N-Term(Dimethyl); K2(Dimethyl); LKPEYDIMCK Q9CZ30-2 1 1380.727 2.59 ATPase 1 C9(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Obg-like K2(HeavyDimethyl); LKPEYDIMCK Q9CZ30-2 2 1404.862 2.71 ATPase 1 C9(Carbamidomethyl); K10(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl); K2(Dimethyl); LKPPFPADVGVFGCPTTVANVETVAVS [ubiquinone] D3Z1U9 C14(Carbamidomethyl); 1 3455.808 4.60 PTICR flavoprotein 1, C31(Carbamidomethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); LKPPFPADVGVFGCPTTVANVETVAVS [ubiquinone] K2(HeavyDimethyl); D3Z1U9 3 3471.913 4.37 PTICR flavoprotein 1, C14(Carbamidomethyl); mitochondrial C31(Carbamidomethyl)

NADH dehydrogenase N-Term(Dimethyl); K2(Dimethyl); LKPPFPADVGVFGCPTTVANVETVAVS [ubiquinone] D3Z1U9 C14(Carbamidomethyl); 1 3611.899 2.97 PTICRR flavoprotein 1, C31(Carbamidomethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); LKPPFPADVGVFGCPTTVANVETVAVS [ubiquinone] K2(HeavyDimethyl); D3Z1U9 1 3628.006 3.44 PTICRR flavoprotein 1, C14(Carbamidomethyl); mitochondrial C31(Carbamidomethyl) Isoform 2 of NAD N-Term(Dimethyl); K2(Dimethyl); LKPVIGVNTDPERSEGHLCLPVR Q8C5H8-2 1 2642.449 3.11 kinase 2, mitochondrial C19(Carbamidomethyl) Disheveled-associated K2(Dimethyl); M15(Oxidation); LKQMLEVVLAIGNFMNKGQR Q80U19 activator of 1 2361.346 3.26 K17(Dimethyl) morphogenesis 2 N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); LKSDGALVDCGTSAQK Q64105 Sepiapterin reductase 1 1758.042 2.52 C10(Carbamidomethyl); K16(HeavyDimethyl) Acyl-CoA synthetase N-Term(Dimethyl); K2(Dimethyl); LKSGETTTAEEIKAFCK Q8VCW8 family member 2, K13(Dimethyl); C16(Carbamidomethyl); 1 2025.087 2.65 mitochondrial K17(Dimethyl)

LKSVTSQPRVTDLLDAIEDMDLCHVVP MCG16556, isoform K2(Dimethyl); C23(Carbamidomethyl); Q9DAY6 1 3636.884 3.13 SDQAK CRA_a K32(Dimethyl) LKTFETYDTFRSWTPQEMAAAGFYHT Baculoviral IAP repeat- K2(HeavyDimethyl); Q9QWK5 1 3454.820 3.11 GVK containing protein 1a K29(HeavyDimethyl) Leucine-rich repeat and N-Term(Dimethyl); K2(Dimethyl); LKVSLPCDLGAALTDGVVLCHLANHV calponin homology E9Q892 C7(Carbamidomethyl); 1 4661.570 2.91 RPRSVPSIHVPSPAVPK domain-containing C20(Carbamidomethyl); K43(Dimethyl) protein 3 (Fragment) N-Term(Dimethyl); 40S ribosomal protein LLACIASRPGQCGR P62242 C4(Carbamidomethyl); 1 1586.824 2.26 S8 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein LLACIASRPGQCGR P62242 C4(Carbamidomethyl); 1 1594.863 2.17 S8 C12(Carbamidomethyl) LLAENIHCFYLGHSSPTPGVEALGASL Bile acyl-CoA N-Term(Dimethyl); Q4LDG0 2 4158.101 4.40 DAAPSDPVPASLR synthetase C8(Carbamidomethyl) LLAENIHCFYLGHSSPTPGVEALGASL Bile acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); Q4LDG0 1 4166.126 3.94 DAAPSDPVPASLR synthetase C8(Carbamidomethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); LLCGGERLGER Q9CZS1 dehydrogenase X, 2 1295.729 2.44 C3(Carbamidomethyl) mitochondrial Aldehyde N-Term(Dimethyl); LLCGGGAAADR P47738 dehydrogenase, 4 1088.547 3.37 C3(Carbamidomethyl) mitochondrial Aldehyde N-Term(Dimethyl:2H(6)13C(2)); LLCGGGAAADR P47738 dehydrogenase, 5 1096.592 3.11 C3(Carbamidomethyl) mitochondrial Aldehyde N-Term(Dimethyl); LLCGGGAAADRGYFIQPTVFGDVK P47738 dehydrogenase, 5 2568.324 4.78 C3(Carbamidomethyl); K24(Dimethyl) mitochondrial Aldehyde N-Term(Dimethyl:2H(6)13C(2)); LLCGGGAAADRGYFIQPTVFGDVK P47738 dehydrogenase, C3(Carbamidomethyl); 3 2584.413 3.15 mitochondrial K24(HeavyDimethyl) Macrophage migration N-Term(Dimethyl); LLCGLLSDRLHISPDR P34884 1 1893.049 2.74 inhibitory factor C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit LLCNFMRQECLDSR Q9R1P4 C3(Carbamidomethyl); 3 1877.925 2.76 alpha type-1 C10(Carbamidomethyl) N-Term(Dimethyl); Isoform 2 of C3(Carbamidomethyl); LLCNGDNDCGDQSDEANCR Q8BH35-2 Complement component 1 2240.861 2.44 C9(Carbamidomethyl); C8 beta chain C18(Carbamidomethyl) Estradiol 17 beta- N-Term(Dimethyl); LLDFCR D3Z3P8 dehydrogenase 5 2 851.443 2.28 C5(Carbamidomethyl) (Fragment) Estradiol 17 beta- N-Term(Dimethyl:2H(6)13C(2)); LLDFCR D3Z3P8 dehydrogenase 5 2 859.485 2.13 C5(Carbamidomethyl) (Fragment) Serine/threonine-protein LLDFLLQPSHLQAMVAWVTQEPPASG Q7TSI3 phosphatase 6 regulatory N-Term(Dimethyl); K33(Dimethyl) 1 3879.058 3.09 EERLRYK subunit 1 N-Term(Dimethyl); LLEACTFHKH Q921I1 Serotransferrin 1 1311.683 2.49 C5(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLEACTFHKH Q921I1 Serotransferrin C5(Carbamidomethyl); 2 1327.772 2.51 K9(HeavyDimethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); LLEAGDFICQALNR P38060 CoA lyase, 3 1647.847 3.36 C9(Carbamidomethyl) mitochondrial Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); LLEAGDFICQALNR P38060 CoA lyase, 1 1655.902 2.79 C9(Carbamidomethyl) mitochondrial Alanine N-Term(Dimethyl); LLEETGICVVPGSGFGQR Q8BGT5 2 1947.006 3.22 aminotransferase 2 C8(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); LLEETGICVVPGSGFGQR Q8BGT5 2 1955.045 3.82 aminotransferase 2 C8(Carbamidomethyl) 3-ketoacyl-CoA thiolase N-Term(Dimethyl); K6(Dimethyl); LLENEKARDCLIPMGITSENVAER Q8VCH0 2 2814.443 3.81 B, peroxisomal C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase LLENEKARDCLIPMGITSENVAER Q8VCH0 K6(HeavyDimethyl); 5 2830.531 3.96 B, peroxisomal C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase LLENEKARDCLIPMGITSENVAER Q8VCH0 K6(HeavyDimethyl); 1 2846.531 3.42 B, peroxisomal C10(Carbamidomethyl); M14(Oxidation)

3-ketoacyl-CoA thiolase N-Term(Dimethyl); K6(Dimethyl); LLESEKARDCLTPMGMTSENVAER Q921H8 1 2793.356 4.12 A, peroxisomal C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LLGLPLPEQGDQDGSQEEEMSSLEKPT K25(HeavyDimethyl); Q8BG17 Nucleolar protein 12 1 3765.171 2.86 KALPRK K28(HeavyDimethyl); K33(HeavyDimethyl) Carnitine O- N-Term(Dimethyl); LLGSTIPLCSAQWER P97742 palmitoyltransferase 1, 3 1758.921 3.33 C9(Carbamidomethyl) liver isoform Carnitine O- N-Term(Dimethyl:2H(6)13C(2)); LLGSTIPLCSAQWER P97742 palmitoyltransferase 1, 5 1766.955 3.50 C9(Carbamidomethyl) liver isoform N-Term(Dimethyl); Isoform 3 of APOBEC1 LLGVCASVDNCR Q5YD48-3 C5(Carbamidomethyl); 1 1391.674 2.18 complementation factor C11(Carbamidomethyl)

N-Term(Dimethyl:2H(6)13C(2)); Isoform 3 of APOBEC1 LLGVCASVDNCR Q5YD48-3 C5(Carbamidomethyl); 1 1399.723 2.15 complementation factor C11(Carbamidomethyl) Amine oxidase [flavin- N-Term(Dimethyl); LLHDCGLSVVVLEAR E9PVL9 3 1708.937 3.37 containing] B C5(Carbamidomethyl) Amine oxidase [flavin- N-Term(Dimethyl:2H(6)13C(2)); LLHDCGLSVVVLEAR E9PVL9 2 1716.984 2.56 containing] B C5(Carbamidomethyl) Amine oxidase [flavin- N-Term(Dimethyl:2H(6)13C(2)); LLHDCGLSVVVLEARDR E9PVL9 1 1988.117 2.59 containing] B C5(Carbamidomethyl) Alanine--glyoxylate LLHFSTFGGNPLACAIGSAVLEVIEEEN N-Term(Dimethyl:2H(6)13C(2)); Q3UEG6 aminotransferase 2, 2 3420.805 5.64 LQR C14(Carbamidomethyl) mitochondrial Serine--tRNA ligase, N-Term(Dimethyl); K9(Dimethyl); LLIDEAIQKCDGER A2AFS1 1 1715.895 2.41 cytoplasmic (Fragment) C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Serine--tRNA ligase, LLIDEAIQKCDGER P26638 K9(HeavyDimethyl); 1 1731.987 2.27 cytoplasmic C10(Carbamidomethyl) Isoform 2 of 2- LLISHEAPLTGGFASEISSTVQEECFLNL oxoisovalerate N-Term(Dimethyl:2H(6)13C(2)); Q6P3A8-2 1 3851.997 3.06 EAPISR dehydrogenase subunit C25(Carbamidomethyl) beta, mitochondrial

LLITALFGAGLGWAWLAARAEKEQW Protein SCO2 homolog, Q8VCL2 N-Term(Dimethyl); K22(Dimethyl) 1 2983.623 2.69 R mitochondrial Homogentisate 1,2- N-Term(Dimethyl); K9(Dimethyl); LLIYTEFGKMSLQPNEICVIQR O09173 1 2708.461 3.17 dioxygenase C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- LLIYTEFGKMSLQPNEICVIQR O09173 K9(HeavyDimethyl); 2 2724.537 2.77 dioxygenase C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LLLATMEALNGGKVFANAYLSDLGGC K13(HeavyDimethyl); P24549 Retinal dehydrogenase 1 1 3047.759 3.60 IK C26(Carbamidomethyl); K28(HeavyDimethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); K9(Dimethyl); LLLEGVENKLTPCLK D3Z041 4 1811.075 3.15 CoA ligase 1 C13(Carbamidomethyl); K15(Dimethyl)

Probable N-Term(Dimethyl:2H(6)13C(2)); LLLENAQQVVLVCAR Q9DBA8 4 1762.038 3.27 imidazolonepropionase C13(Carbamidomethyl) Dimethylaniline N-Term(Dimethyl); LLLGPCTPVQYR P97872 monooxygenase [N- 13 1444.799 3.15 C6(Carbamidomethyl) oxide-forming] 5 Dimethylaniline N-Term(Dimethyl:2H(6)13C(2)); LLLGPCTPVQYR P97872 monooxygenase [N- 4 1452.838 2.24 C6(Carbamidomethyl) oxide-forming] 5 N-Term(Dimethyl:2H(6)13C(2)); LLLPWLEARIHEGCEEPATHNALAK Q68FD5 Clathrin heavy chain 1 C14(Carbamidomethyl); 1 2940.643 2.92 K25(HeavyDimethyl)

Isoform 2 of SWI/SNF- related matrix-associated LLLTGTPVQNNLLELMSLLNFVMPHM actin-dependent M26(Oxidation); M37(Oxidation); Q04692-2 1 4729.396 3.57 FSSSTSEIRRMFSSK regulator of chromatin K41(Dimethyl) subfamily A containing DEAD/H box 1

N-Term(Dimethyl); LLMMAGIDDCYTSAR L7N240 Protein Gm6139 2 1744.794 2.94 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LLMMAGIDDCYTSAR L7N240 Protein Gm6139 1 1752.850 3.13 C10(Carbamidomethyl) LLNLRVGDAQGMFEPDGGGRPKGR Q8K596 Protein Slc8a2 K22(Dimethyl) 1 2568.339 2.70 LLNNTWLSKSSEPLDVGSRNPER E9Q4P5 Synaptojanin-2 K9(Dimethyl) 1 2640.399 3.08 N-Term(Dimethyl); LLNQLQYCEEAGIPLVAIIGEQELKDG Histidine--tRNA ligase, Q61035 C8(Carbamidomethyl); K25(Dimethyl); 1 3707.094 3.18 VIKLR cytoplasmic K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLNQLQYCEEAGIPLVAIIGEQELKDG Histidine--tRNA ligase, C8(Carbamidomethyl); Q61035 1 3731.231 3.59 VIKLR cytoplasmic K25(HeavyDimethyl); K30(HeavyDimethyl) 5-oxoprolinase N-Term(Dimethyl); LLPASFPCIFGPGEDQPLSPEASR E9Q484 3 2613.323 4.03 (Fragment) C8(Carbamidomethyl) 5-oxoprolinase N-Term(Dimethyl:2H(6)13C(2)); LLPASFPCIFGPGEDQPLSPEASR E9Q484 2 2621.346 3.24 (Fragment) C8(Carbamidomethyl) N-Term(Dimethyl); K8(Dimethyl); LLPLELEKTACQEYTVTEFQPLYYVAE Phenylalanine-4- P16331 C11(Carbamidomethyl); K33(Dimethyl); 5 4279.198 4.30 SFNDAKEK hydroxylase K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K8(HeavyDimethyl); LLPLELEKTACQEYTVTEFQPLYYVAE Phenylalanine-4- P16331 C11(Carbamidomethyl); 2 4311.373 4.69 SFNDAKEK hydroxylase K33(HeavyDimethyl); K35(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLPSKVTSATQLNGRQAQPSSKPASDV Protein LSM14 homolog Q8BM41 K5(HeavyDimethyl); 1 4758.645 2.66 VQPAPVHTQGQVNDENR B K22(HeavyDimethyl) Methylmalonate- semialdehyde LLQDSGAPDGTLNIIHGQHDAVNFICD N-Term(Dimethyl); Q9EQ20 dehydrogenase 4 3566.761 4.36 HPDIK C26(Carbamidomethyl); K32(Dimethyl) [acylating], mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl:2H(6)13C(2)); LLQDSGAPDGTLNIIHGQHDAVNFICD Q9EQ20 dehydrogenase C26(Carbamidomethyl); 3 3582.848 3.91 HPDIK [acylating], K32(HeavyDimethyl) mitochondrial N-Term(Dimethyl); LLQLACPGTGEADAR Q8K1B3 Gltpd2 protein 1 1599.811 2.53 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LLQLACPGTGEADAR Q8K1B3 Gltpd2 protein 2 1607.880 2.57 C6(Carbamidomethyl) Isoform 4 of LLQSNPVLEAFGNAKTLRNDNSSR Q9WTI7-4 Unconventional myosin- K15(HeavyDimethyl) 1 2680.431 2.86 Ic Isoform Stat3B of Signal LLQTAATAAQQGGQANHPTAAVVTE N-Term(Dimethyl:2H(6)13C(2)); P42227-2 transducer and activator 1 4170.236 3.82 KQQMLEQHLQDVR K26(HeavyDimethyl); M29(Oxidation) of transcription 3 E3 ubiquitin-protein LLQTISDLMMSLPSGSSLQQMALRCWS M9(Oxidation); C25(Carbamidomethyl); F6T4V9 ligase MYCBP2 1 3346.787 2.95 LK K29(HeavyDimethyl) (Fragment) Basement membrane- specific heparan sulfate N-Term(Dimethyl); LLQVTPTDSGEYVCR B1B0C7 7 1765.872 3.17 proteoglycan core C14(Carbamidomethyl) protein Basement membrane- specific heparan sulfate N-Term(Dimethyl:2H(6)13C(2)); LLQVTPTDSGEYVCR B1B0C7 4 1773.916 3.30 proteoglycan core C14(Carbamidomethyl) protein LLSHCLLVTLASHHPADFTPAVHASLD Hemoglobin subunit N-Term(Dimethyl); P01942 2 3106.653 4.16 K alpha C5(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLSHCLLVTLASHHPADFTPAVHASLD Hemoglobin subunit P01942 C5(Carbamidomethyl); 1 3122.740 3.72 K alpha K28(HeavyDimethyl) N-Term(Dimethyl); LLSHCLLVTLASHHPADFTPAVHASLD Hemoglobin subunit P01942 C5(Carbamidomethyl); K28(Dimethyl); 6 4368.410 5.58 KFLASVSTVLTSK alpha K40(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLSHCLLVTLASHHPADFTPAVHASLD Hemoglobin subunit C5(Carbamidomethyl); P01942 3 4392.507 3.44 KFLASVSTVLTSK alpha K28(HeavyDimethyl); K40(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LLSTVAQAVKGQGTVCWVDCGDAES Protein disulfide- K10(HeavyDimethyl); Q921X9 1 2879.516 4.19 R isomerase A5 C16(Carbamidomethyl); C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal membrane C10(Carbamidomethyl); LLTWLSVLECVEVFMEMGAAK Q91XC9 1 2530.340 2.17 protein PEX16 M15(Oxidation); M17(Oxidation); K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ras-related protein Rab- K6(HeavyDimethyl); LLVGNKCDLTTK Q5SW87 4 1469.975 2.66 1A C7(Carbamidomethyl); K12(HeavyDimethyl) LLVGVRDGGQPPLSATATLLLVFADSL MCG133388, isoform Q91XX4 2 3848.071 3.43 QEALPDLSDR CRA_n UDP- LLVVPMDGSHWFDMQMVVEKLIQR D3Z7G0 glucuronosyltransferase K20(HeavyDimethyl) 1 2907.556 2.89 1-7C (Fragment) LLVVSAQFNHCRTVLRLFDDLAMFVY Peroxisomal membrane N-Term(Dimethyl); Q3TN90 1 3412.832 3.05 TK protein 11C C11(Carbamidomethyl); K28(Dimethyl) LLVVTDPRADHQPLTEASYVNLPTIAL 40S ribosomal protein N-Term(Dimethyl); P14206 6 3918.045 4.73 CNTDSPLR SA C28(Carbamidomethyl) LLVVTDPRADHQPLTEASYVNLPTIAL 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); P14206 4 3926.113 5.24 CNTDSPLR SA C28(Carbamidomethyl) LLVVYPWTQRYFDSFGDLSSASAIMG N-Term(Dimethyl:2H(6)13C(2)); A8DUK4 Beta-globin 3 3308.774 5.06 NAK K29(HeavyDimethyl) Persulfide dioxygenase N-Term(Dimethyl:2H(6)13C(2)); LLYAVNTHCHADHITGTGVLR Q9DCM0 1 2384.267 2.39 ETHE1, mitochondrial C9(Carbamidomethyl) Fructose-1,6- N-Term(Dimethyl); LLYECNPIAYVMEK Q9QXD6 17 1798.902 4.94 bisphosphatase 1 C5(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl); Fructose-1,6- LLYECNPIAYVMEK Q9QXD6 C5(Carbamidomethyl); M12(Oxidation); 7 1814.905 3.87 bisphosphatase 1 K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fructose-1,6- LLYECNPIAYVMEK Q9QXD6 C5(Carbamidomethyl); 15 1814.999 5.05 bisphosphatase 1 K14(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fructose-1,6- LLYECNPIAYVMEK Q9QXD6 C5(Carbamidomethyl); M12(Oxidation); 4 1830.992 3.16 bisphosphatase 1 K14(HeavyDimethyl)

N-Term(Dimethyl); LLYECNPIAYVMEKAGGLATTGDKDIL Fructose-1,6- Q9QXD6 C5(Carbamidomethyl); K14(Dimethyl); 1 4228.248 3.12 DIVPTEIHQK bisphosphatase 1 K24(Dimethyl); K37(Dimethyl) GDH/6PGL endoplasmic N-Term(Dimethyl); K4(Dimethyl); LMDKVLESLSCPK A2A7A8 2 1603.875 2.17 bifunctional protein C11(Carbamidomethyl); K13(Dimethyl) (Fragment) N-Term(Dimethyl); LMEPIYLVEIQCPEQVVGGIYGVLNR P58252 Elongation factor 2 13 3017.581 5.96 C12(Carbamidomethyl) N-Term(Dimethyl); M2(Oxidation); LMEPIYLVEIQCPEQVVGGIYGVLNR P58252 Elongation factor 2 6 3033.588 4.87 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LMEPIYLVEIQCPEQVVGGIYGVLNR P58252 Elongation factor 2 11 3025.639 5.65 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LMEPIYLVEIQCPEQVVGGIYGVLNR P58252 Elongation factor 2 1 3041.643 3.43 M2(Oxidation); C12(Carbamidomethyl)

N-Term(Dimethyl); LMEPIYLVEIQCPEQVVGGIYGVLNRK P58252 Elongation factor 2 2 3173.700 3.31 C12(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LMEPIYLVEIQCPEQVVGGIYGVLNRK P58252 Elongation factor 2 C12(Carbamidomethyl); 2 3189.818 3.56 K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LMEPIYLVEIQCPEQVVGGIYGVLNRK P58252 Elongation factor 2 C12(Carbamidomethyl); 2 3345.903 3.24 R K27(HeavyDimethyl) LMLSVPLTNDGKYVLLNDQADDTGGS DCC-interacting protein Q8K3G9 K12(HeavyDimethyl) 1 3899.862 2.90 PSENRGAESEA 13-beta UDP-glucuronic acid N-Term(Dimethyl:2H(6)13C(2)); LMMDGHEVTVVDNFFTGR D3YUF9 decarboxylase 1 1 2136.055 2.21 M2(Oxidation); M3(Oxidation) (Fragment) PR domain zinc finger LMWEVRGSKGEVLYILDATNPR E9Q707 K9(Dimethyl) 1 2575.338 2.39 protein 5 Serum N-Term(Dimethyl); LNAFREVTPVELPNCNLVK H3BK03 paraoxonase/arylesterase 3 2269.234 2.84 C15(Carbamidomethyl); K19(Dimethyl) 1 (Fragment) Serum N-Term(Dimethyl:2H(6)13C(2)); LNAFREVTPVELPNCNLVK H3BK03 paraoxonase/arylesterase C15(Carbamidomethyl); 3 2285.326 3.22 1 (Fragment) K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); LNCQVIGASVDSHFCHLAWINTPK P35700 Peroxiredoxin-1 1 2839.513 2.59 C15(Carbamidomethyl); K24(HeavyDimethyl) Isoform 3 of Solute N-Term(Dimethyl); K6(Dimethyl); LNDRFKVDVVGNITTGLIPPVAPK Q8CIW6-3 carrier family 26 1 2647.549 2.99 K24(Dimethyl) member 6 Proteasome subunit N-Term(Dimethyl); LNEDMACSVAGITSDANVLTNELR E9PW69 1 2621.292 3.12 alpha type (Fragment) C7(Carbamidomethyl) Proteasome subunit N-Term(Dimethyl:2H(6)13C(2)); LNEDMACSVAGITSDANVLTNELR E9PW69 1 2629.309 2.33 alpha type (Fragment) C7(Carbamidomethyl) Isoform 2 of UTP-- N-Term(Dimethyl); LNGGLGTSMGCKGPK Q91ZJ5-2 glucose-1-phosphate C11(Carbamidomethyl); K12(Dimethyl); 1 1560.820 2.36 uridylyltransferase K15(Dimethyl) LNHNKLSDAGLPSRGFDVSSILDLQLS O35367 Keratocan K5(Dimethyl) 1 4058.063 3.21 YNQLTNFPR Calmodulin-regulated LNHTDGKSSGSSSQKTTPEGSELNIPHV K7(HeavyDimethyl); Q8C1B1 spectrin-associated 1 4627.401 3.05 VSWAQIPEEAGVAPGR K15(HeavyDimethyl) protein 2 Isoform 2 of Cytosol N-Term(Dimethyl); LNLPINIIGLAPLCENMPSGK Q9CPY7-2 1 2320.278 4.39 aminopeptidase C14(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol LNLPINIIGLAPLCENMPSGK Q9CPY7-2 C14(Carbamidomethyl); 1 2336.367 4.20 aminopeptidase K21(HeavyDimethyl) C11(Carbamidomethyl); LNLQGNQVSPCGGPAEPGPPGCVDFSG MCG51019, isoform C22(Carbamidomethyl); G3XA59 1 4695.154 3.01 IPTLHVLNMAGNSMGMLR CRA_b M36(Oxidation); M41(Oxidation); M43(Oxidation) LNNLSPPASLKEISLVQLDSMSLSHQM Adenylate cyclase type E9Q9T4 N-Term(Dimethyl); K11(Dimethyl) 1 3376.857 3.13 LVR 10 LNPNFLVDFGKEPLGPALAHELRYPGG Selenium-binding N-Term(Dimethyl); K11(Dimethyl); G3UYY2 1 3953.986 4.38 DCSSDIWI protein 2 C29(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LNPNFLVDFGKEPLGPALAHELRYPGG Selenium-binding G3UYY2 K11(HeavyDimethyl); 1 3970.111 3.08 DCSSDIWI protein 2 C29(Carbamidomethyl) Calcium-activated LNRMNQASRLFLLQTVEQGSWVGMV Q9D7Z6 chloride channel K38(HeavyDimethyl) 1 4353.224 3.52 TFDSAAYVQSELK regulator 1 Isoamyl acetate- N-Term(Dimethyl); LNSVVGEYANACLQVAR Q9DB29 hydrolyzing esterase 1 1 1891.995 3.63 C12(Carbamidomethyl) homolog Isoamyl acetate- N-Term(Dimethyl:2H(6)13C(2)); LNSVVGEYANACLQVAR Q9DB29 hydrolyzing esterase 1 3 1900.009 3.99 C12(Carbamidomethyl) homolog Isoform 3 of Kelch N-Term(Dimethyl); M5(Oxidation); LPATMPEPVYFHCAAVTPAGCMYIHG Q6PAR0-3 domain-containing C13(Carbamidomethyl); 1 4108.952 2.77 GVVNIHENKR protein 10 C21(Carbamidomethyl); K35(Dimethyl)

UDP- N-Term(Dimethyl); LPCSLDSEATQCPVPLSYVPK Q63886 glucuronosyltransferase C3(Carbamidomethyl); 1 2417.214 2.96 1-1 C12(Carbamidomethyl); K21(Dimethyl) Isoform 2 of U3 small nucleolar RNA- LPERSEAGLKVSEFNVSSEGSGEK Q640M1-2 K10(Dimethyl); K24(Dimethyl) 1 2592.341 2.32 associated protein 14 homolog A LPKQASRASETQTSGR Q80US4 Actin-related protein 5 K3(HeavyDimethyl) 2 1752.964 2.31 LPPGPTPLPIIGNILQIDVKDICQSFTNLS N-Term(Dimethyl); K20(Dimethyl); P56654 Cytochrome P450 2C37 1 3472.971 3.21 K C23(Carbamidomethyl); K31(Dimethyl) Peptidyl-glycine alpha- LPVDEEAFVIDFKPR E9Q704 amidating N-Term(Dimethyl); K13(Dimethyl) 1 1830.994 2.36 monooxygenase LQAVAAHRGPELLHQDDALMVQGSL Q8C8E0 Protein Gm13199 N-Term(Dimethyl); M20(Oxidation) 1 3568.767 3.18 QHRYDR Aflatoxin B1 aldehyde N-Term(Dimethyl:2H(6)13C(2)); LQCPRVDLFYLHAPDHSTPVEETLR Q8CG76 1 3029.574 3.32 reductase member 2 C3(Carbamidomethyl) N-Term(Dimethyl); LQDDTSCSAVCK Q9CQ88 Tetraspanin-31 C7(Carbamidomethyl); 2 1439.649 2.35 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LQEFVNQRGMLANGQSCEPGCRTFFR Q9JI71 Delta-like protein 4 C17(Carbamidomethyl); 1 3138.488 2.59 C21(Carbamidomethyl) LQEQASDLVLKASHIGMLQATQMTQE Protein Fam184a K11(HeavyDimethyl); F6TU77 1 3383.893 3.49 VTIK (Fragment) K30(HeavyDimethyl) Baculoviral IAP repeat- LQFDTFEMVSEDDDGK S4R1L5 K16(HeavyDimethyl) 1 1911.900 2.07 containing protein 6 Leucine-rich repeat and LQGNYLREPPSLR Q0P5X1 IQ domain-containing N-Term(Dimethyl:2H(6)13C(2)) 1 1578.905 2.21 protein 1 NFU1 iron-sulfur cluster N-Term(Dimethyl); LQGSCTSCPSSIITLK Q9QZ23 scaffold homolog, C5(Carbamidomethyl); 1 1807.929 2.79 mitochondrial C8(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NFU1 iron-sulfur cluster C5(Carbamidomethyl); LQGSCTSCPSSIITLK Q9QZ23 scaffold homolog, 1 1824.011 2.54 C8(Carbamidomethyl); mitochondrial K16(HeavyDimethyl) Isoform 5 of E3 N-Term(Dimethyl:2H(6)13C(2)); LQGVASQSEAYLK O88196-5 ubiquitin-protein ligase 1 1465.896 2.01 K13(HeavyDimethyl) TTC3 N-Term(Dimethyl); LQHFSAVFLLILCLGMMSAAPPPDPSL C13(Carbamidomethyl); P12399 Protein CTLA-2-alpha 1 4141.120 3.20 DNEWKEWK M16(Oxidation); K32(Dimethyl); K35(Dimethyl) Electron transfer N-Term(Dimethyl); flavoprotein-ubiquinone LQINAQNCVHCK Q6PF96 C8(Carbamidomethyl); 3 1540.774 2.49 oxidoreductase, C11(Carbamidomethyl); K12(Dimethyl) mitochondrial Isoform 2 of Phosphatidylinositol 4- N-Term(Dimethyl:2H(6)13C(2)); LQKDRQMTDSPR Q61194-2 phosphate 3-kinase C2 1 1562.887 2.00 K3(HeavyDimethyl); M7(Oxidation) domain-containing subunit alpha Cyclin-dependent kinase N-Term(Dimethyl:2H(6)13C(2)); LQLESMLLETGHR Q9D0V8 1 1578.887 1.97 2-interacting protein M6(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Pseudouridine-5'- LQMVLHTAGFMPGAEELIHHLKK Q9D5U5 K22(HeavyDimethyl); 1 2708.619 2.69 monophosphatase K23(HeavyDimethyl) LQNLDGTCADSYSFVFSRDPNGLSPET Retinol-binding protein N-Term(Dimethyl:2H(6)13C(2)); Q00724 1 3338.643 2.93 RR 4 C8(Carbamidomethyl) N-Term(Dimethyl); K11(Dimethyl); LQQDDEHREEKQK P17141 Zinc finger protein 37 2 1766.914 2.30 K13(Dimethyl) Geranylgeranyl N-Term(Dimethyl); LQQSAALQTLASCPR Q9JHK4 transferase type-2 1 1671.881 2.19 C13(Carbamidomethyl) subunit alpha N-Term(Dimethyl); C4(Carbamidomethyl); LQTCCDKPLLK P07724 Serum albumin 10 1459.796 3.85 C5(Carbamidomethyl); K7(Dimethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); LQTCCDKPLLK P07724 Serum albumin C5(Carbamidomethyl); 9 1483.929 3.72 K7(HeavyDimethyl); K11(HeavyDimethyl) N-Term(Dimethyl); C4(Carbamidomethyl); LQTCCDKPLLKK P07724 Serum albumin 5 1615.920 2.74 C5(Carbamidomethyl); K7(Dimethyl); K11(Dimethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); C5(Carbamidomethyl); LQTCCDKPLLKK P07724 Serum albumin 9 1648.100 3.39 K7(HeavyDimethyl); K11(HeavyDimethyl); K12(HeavyDimethyl) Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LQTQPPSLSGQPPMYSGTLDCFR Q9Z2Z6 carnitine/acylcarnitine 1 2616.322 2.21 C21(Carbamidomethyl) carrier protein Mitochondrial N-Term(Dimethyl:2H(6)13C(2)); LQTQPPSLSGQPPMYSGTLDCFRK Q9Z2Z6 carnitine/acylcarnitine C21(Carbamidomethyl); 1 2780.450 3.31 carrier protein K24(HeavyDimethyl)

N-Term(Dimethyl); K5(Dimethyl); LQTVKLPVDKTTSCCFGGK Q64374 Regucalcin K10(Dimethyl); C14(Carbamidomethyl); 3 2251.217 2.98 C15(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K5(HeavyDimethyl); K10(HeavyDimethyl); LQTVKLPVDKTTSCCFGGK Q64374 Regucalcin 2 2283.395 2.90 C14(Carbamidomethyl); C15(Carbamidomethyl); K19(HeavyDimethyl) N-Term(Dimethyl); LQVTASPQSLCGLR P28665 Murinoglobulin-1 6 1557.838 3.45 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LQVTASPQSLCGLR P28665 Murinoglobulin-1 5 1565.880 3.43 C11(Carbamidomethyl) Carbamoyl-phosphate N-Term(Dimethyl); LRDADPILRCEMASTGEVACFGEGIHT Q8C196 synthase [ammonia], C10(Carbamidomethyl); 1 3520.756 3.10 AFLK mitochondrial C20(Carbamidomethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate LRDADPILRCEMASTGEVACFGEGIHT C10(Carbamidomethyl); Q8C196 synthase [ammonia], 1 3536.836 3.16 AFLK C20(Carbamidomethyl); mitochondrial K31(HeavyDimethyl) Ribosome-binding N-Term(Dimethyl); LREAEETQNSLQAECDQYR A2AVJ7 3 2368.073 3.66 protein 1 C15(Carbamidomethyl) Ribosome-binding N-Term(Dimethyl:2H(6)13C(2)); LREAEETQNSLQAECDQYR A2AVJ7 3 2376.128 3.15 protein 1 C15(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); LRECLPLIIFLR P62702 5 1570.955 2.88 S4, X isoform C4(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); LRECLPLIIFLR P62702 4 1578.999 3.12 S4, X isoform C4(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl); LRGEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate 8 2052.987 4.37 C10(Carbamidomethyl); K17(Dimethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); LRGEDGESECVINYVEK Q8R0Y6 formyltetrahydrofolate C10(Carbamidomethyl); 6 2069.078 4.54 dehydrogenase K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytosolic 10- C10(Carbamidomethyl); LRGEDGESECVINYVEKAVK Q8R0Y6 formyltetrahydrofolate 2 2403.351 3.33 K17(HeavyDimethyl); dehydrogenase K20(HeavyDimethyl) Trifunctional enzyme LRKDGGQYALVAACAAGGQGHAMIV N-Term(Dimethyl); K3(Dimethyl); Q99JY0 subunit beta, 1 3186.652 3.17 EAYPK C14(Carbamidomethyl); K30(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme LRKDGGQYALVAACAAGGQGHAMIV K3(HeavyDimethyl); Q99JY0 subunit beta, 1 3210.787 3.46 EAYPK C14(Carbamidomethyl); mitochondrial K30(HeavyDimethyl) Fructose-1,6- N-Term(Dimethyl); LRLLYECNPIAYVMEK Q9QXD6 1 2068.104 2.54 bisphosphatase 1 C7(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fructose-1,6- LRLLYECNPIAYVMEK Q9QXD6 C7(Carbamidomethyl); 1 2084.188 3.52 bisphosphatase 1 K16(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); LRVQELSLSAPLTVLPTVTCEDTIAILR Q91WT9-2 Cystathionine beta- 4 3136.783 3.96 C20(Carbamidomethyl) synthase Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); LRVQELSLSAPLTVLPTVTCEDTIAILR Q91WT9-2 Cystathionine beta- 1 3144.807 3.50 C20(Carbamidomethyl) synthase LSAAEGSFLDDTDLVER E9Q7N9 Protein Dnah11 1 1837.896 2.12 NCK-interacting protein N-Term(Dimethyl); LSDLQATLRRILTEEEASPQCQMDR Q9ESJ4 1 2988.445 2.89 with SH3 domain C21(Carbamidomethyl) N-Term(Dimethyl); LSEDQEDCILYSSWLAEK P28665 Murinoglobulin-1 1 2242.065 2.72 C8(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LSEDQEDCILYSSWLAEK P28665 Murinoglobulin-1 C8(Carbamidomethyl); 1 2258.151 2.37 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); LSELVQAVSDPSSPQYGK O89023 Tripeptidyl-peptidase 1 1 1977.136 2.34 K18(HeavyDimethyl) Gamma-butyrobetaine N-Term(Dimethyl); LSFHTDYPALHHPPGVQLLHCIK Q924Y0 1 2736.443 3.58 dioxygenase C21(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Gamma-butyrobetaine LSFHTDYPALHHPPGVQLLHCIK Q924Y0 C21(Carbamidomethyl); 2 2752.541 3.72 dioxygenase K23(HeavyDimethyl) MCG142671, isoform N-Term(Dimethyl); LSGCEAMDSEALVR Q6PDB7 1 1581.737 2.16 CRA_b C4(Carbamidomethyl); M7(Oxidation) MCG142671, isoform N-Term(Dimethyl:2H(6)13C(2)); LSGCEAMDSEALVR Q6PDB7 1 1573.783 2.10 CRA_b C4(Carbamidomethyl) MCG142671, isoform N-Term(Dimethyl:2H(6)13C(2)); LSGCEAMDSEALVR Q6PDB7 2 1589.783 2.32 CRA_b C4(Carbamidomethyl); M7(Oxidation) N-Term(Dimethyl); LSGCEAMDSQALVR Q91WG0 Acylcarnitine hydrolase 9 1564.744 4.47 C4(Carbamidomethyl) N-Term(Dimethyl); LSGCEAMDSQALVR Q91WG0 Acylcarnitine hydrolase 7 1580.733 2.95 C4(Carbamidomethyl); M7(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); LSGCEAMDSQALVR Q91WG0 Acylcarnitine hydrolase 21 1572.786 4.68 C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LSGCEAMDSQALVR Q91WG0 Acylcarnitine hydrolase 2 1588.787 2.07 C4(Carbamidomethyl); M7(Oxidation) Peroxisomal LSGDWNPLHIDPDFASVAGFEKPILHG N-Term(Dimethyl); K22(Dimethyl); P51660 multifunctional enzyme 1 4028.016 4.66 LCTFGFSAR C29(Carbamidomethyl) type 2 Peroxisomal N-Term(Dimethyl:2H(6)13C(2)); LSGDWNPLHIDPDFASVAGFEKPILHG P51660 multifunctional enzyme K22(HeavyDimethyl); 1 4044.096 3.62 LCTFGFSAR type 2 C29(Carbamidomethyl) LSGVERANSVTWNPHKMMGVPLQCS Glutamate K16(HeavyDimethyl); P48320 1 3386.777 3.12 ALLVR decarboxylase 2 C24(Carbamidomethyl) GRIP1-associated N-Term(Dimethyl); K3(Dimethyl); LSKECVGSPDPDLEPGEAN A2AEW9 1 2069.977 2.33 protein 1 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LSLCGEESFGTGSDHIR Q9D0F9 Phosphoglucomutase-1 1 1900.917 2.75 C4(Carbamidomethyl) Polypyrimidine tract- N-Term(Dimethyl); LSLDGQNIYNACCTLR F7AXP1 binding protein 1 C12(Carbamidomethyl); 3 1925.916 2.35 (Fragment) C13(Carbamidomethyl) Polypyrimidine tract- N-Term(Dimethyl:2H(6)13C(2)); LSLDGQNIYNACCTLR F7AXP1 binding protein 1 C12(Carbamidomethyl); 3 1933.963 3.60 (Fragment) C13(Carbamidomethyl) Aldehyde N-Term(Dimethyl); K8(Dimethyl); LSLELGGKNPAIIFEDANLEECIPATVR Q8BH00 dehydrogenase family 8 2 3125.666 3.50 C22(Carbamidomethyl) member A1 Aldehyde N-Term(Dimethyl:2H(6)13C(2)); LSLELGGKNPAIIFEDANLEECIPATVR Q8BH00 dehydrogenase family 8 K8(HeavyDimethyl); 1 3141.747 2.89 member A1 C22(Carbamidomethyl) LSLHHNELQALPGAALSQAR E9Q7T7 Protein Chadl N-Term(Dimethyl) 1 2154.175 2.68 N-Term(Dimethyl); LSLQNCGLTEAGCGILPGMLR Q91VI7 Ribonuclease inhibitor C6(Carbamidomethyl); 1 2288.170 3.28 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LSLQNCGLTEAGCGILPGMLR Q91VI7 Ribonuclease inhibitor C6(Carbamidomethyl); 1 2296.210 2.49 C13(Carbamidomethyl) Isoform 3 of Microtubule-associated LSMENEELLWK Q5HZI1-3 N-Term(Dimethyl); K11(Dimethyl) 1 1447.763 2.07 tumor suppressor 1 homolog E3 ubiquitin-protein N-Term(Dimethyl); M3(Oxidation); LSMGQSKDFLQISEAVR Q80X56 1 1981.022 2.78 ligase TRIM69 K7(Dimethyl) 60 kDa N-Term(Dimethyl); LSPQELEDVGTELCR A0JNU3 2 1773.877 2.55 lysophospholipase C14(Carbamidomethyl) 5-hydroxyisourate N-Term(Dimethyl); LSRLEAPCQQWMELR Q9CRB3 13 1944.978 4.71 hydrolase C8(Carbamidomethyl) 5-hydroxyisourate N-Term(Dimethyl); LSRLEAPCQQWMELR Q9CRB3 1 1960.963 2.40 hydrolase C8(Carbamidomethyl); M12(Oxidation) 5-hydroxyisourate N-Term(Dimethyl:2H(6)13C(2)); LSRLEAPCQQWMELR Q9CRB3 9 1953.007 4.31 hydrolase C8(Carbamidomethyl) 5-hydroxyisourate N-Term(Dimethyl:2H(6)13C(2)); LSRLEAPCQQWMELR Q9CRB3 1 1969.014 2.83 hydrolase C8(Carbamidomethyl); M12(Oxidation) 5-oxoprolinase N-Term(Dimethyl); LSRLEEQCVDALQAQGFSR E9Q484 1 2235.112 3.31 (Fragment) C8(Carbamidomethyl) 5-oxoprolinase N-Term(Dimethyl:2H(6)13C(2)); LSRLEEQCVDALQAQGFSR E9Q484 3 2243.161 3.97 (Fragment) C8(Carbamidomethyl) Acyl-CoA dehydrogenase family N-Term(Dimethyl:2H(6)13C(2)); LSSGEHIAAFCLTEPASGSDAASIQTR Q8JZN5 1 2812.401 2.78 member 9, C11(Carbamidomethyl) mitochondrial N-acetylglutamate LSTARAHAEDAEGAK Q8R4H7 K15(HeavyDimethyl) 1 1562.821 2.01 synthase, mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Aminoacyl tRNA C9(Carbamidomethyl); LSTPLQTNCTASESVVQSPSVATTASP synthase complex- P31230 K30(HeavyDimethyl); 1 4190.365 3.65 ATKEQIKAGEEK interacting K34(HeavyDimethyl); multifunctional protein 1 K39(HeavyDimethyl) LSTQFENLMAESRQGLEEEYEPQLLR Q9EPM5-3 Isoform 3 of Syncoilin N-Term(Dimethyl) 1 3138.551 2.46 LSVLEAAILPQEGRFQALGEMADILRQ Protein Sptbn5 F7BYG3 1 4344.189 2.89 EEYHSWADMAR (Fragment) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); LSVPCVSPKPQKPWEKDAWEIPRESLQ Isoform 2 of Tyrosine- K9(HeavyDimethyl); P08103-2 1 3773.232 3.22 MEK protein kinase HCK K12(HeavyDimethyl); K16(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl); LSVPTYGLQCTQAAPLDSIPNLAAYYI P19096 Fatty acid synthase C10(Carbamidomethyl); 1 3511.778 4.08 DCIK C29(Carbamidomethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LSVPTYGLQCTQAAPLDSIPNLAAYYI C10(Carbamidomethyl); P19096 Fatty acid synthase 1 3527.885 3.46 DCIK C29(Carbamidomethyl); K31(HeavyDimethyl) Glutathione S- N-Term(Dimethyl); LSVQCLLH Q99L20 3 997.554 2.36 transferase theta 3 C5(Carbamidomethyl) Glutathione S- N-Term(Dimethyl:2H(6)13C(2)); LSVQCLLH Q99L20 2 1005.595 2.50 transferase theta 3 C5(Carbamidomethyl) UPF0598 protein N-Term(Dimethyl); LSYCGGGEALAIPFEPAR Q8VE95 2 1935.969 2.54 C8orf82 homolog C4(Carbamidomethyl) Glycine N- N-Term(Dimethyl); LSYYPHCLASFTELVR Q9QXF8 19 1984.006 4.26 methyltransferase C7(Carbamidomethyl) Glycine N- N-Term(Dimethyl:2H(6)13C(2)); LSYYPHCLASFTELVR Q9QXF8 15 1992.041 4.09 methyltransferase C7(Carbamidomethyl) Isoform 2 of Kynurenine- N-Term(Dimethyl); LTAIPVSAFCDSK Q71RI9-2 -oxoglutarate 6 1464.773 3.06 C10(Carbamidomethyl); K13(Dimethyl) transaminase 3

Isoform 2 of Kynurenine- N-Term(Dimethyl:2H(6)13C(2)); LTAIPVSAFCDSK Q71RI9-2 -oxoglutarate C10(Carbamidomethyl); 2 1480.859 2.65 transaminase 3 K13(HeavyDimethyl) LTDADAMKYTIVVSATASDAAPLQYL ATP synthase subunit N-Term(Dimethyl); K8(Dimethyl); D3Z6F5 1 4290.060 4.95 APYSGCSMGEYFR alpha C32(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LTDADAMKYTIVVSATASDAAPLQYL ATP synthase subunit D3Z6F5 K8(HeavyDimethyl); 2 4306.142 4.24 APYSGCSMGEYFR alpha C32(Carbamidomethyl) K9(HeavyDimethyl); M12(Oxidation); LTDFGLGTKIIMGQKLVTFCGTLPYCA K15(HeavyDimethyl); A2AQX6 Protein Gm14147 1 3979.113 3.28 PELFEDR C20(Carbamidomethyl); C26(Carbamidomethyl) Alanine N-Term(Dimethyl); LTEDLFNQVPGIQCNPLQGAMYAFPR Q8BGT5 8 3007.488 5.14 aminotransferase 2 C14(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); LTEDLFNQVPGIQCNPLQGAMYAFPR Q8BGT5 7 3015.533 4.92 aminotransferase 2 C14(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); LTEGCSFR Q6ZWU9 2 1005.521 2.21 S27 C5(Carbamidomethyl) Solute carrier organic N-Term(Dimethyl); K4(Dimethyl); LTEKESECTDVCR Q9QXZ6 anion transporter family C8(Carbamidomethyl); 1 1682.769 3.43 member 1A1 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Solute carrier organic K4(HeavyDimethyl); LTEKESECTDVCR Q9QXZ6 anion transporter family 1 1698.854 2.57 C8(Carbamidomethyl); member 1A1 C12(Carbamidomethyl) LTEMETMQSQLMAEKLQLQEQLQAET M7(Oxidation); M12(Oxidation); Q8VDD5 Myosin-9 1 4539.185 3.09 ELCAEAEELRAR K15(Dimethyl); C29(Carbamidomethyl) N-Term(Dimethyl); LTESPCALVASQYGWSGNMER F7C312 Endoplasmin (Fragment) 10 2384.103 6.01 C6(Carbamidomethyl) N-Term(Dimethyl); LTESPCALVASQYGWSGNMER F7C312 Endoplasmin (Fragment) 7 2400.096 5.62 C6(Carbamidomethyl); M19(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); LTESPCALVASQYGWSGNMER F7C312 Endoplasmin (Fragment) 10 2392.143 6.24 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LTESPCALVASQYGWSGNMER F7C312 Endoplasmin (Fragment) 2 2408.131 5.33 C6(Carbamidomethyl); M19(Oxidation) ATP-binding cassette LTFGIAILGDPQIFLLDEPTAGLDPFSRH F8WGE3 sub-family A member 8- N-Term(Dimethyl) 1 3337.769 3.01 R A Electron transfer flavoprotein-ubiquinone N-Term(Dimethyl); LTFPGGLLIGCSPGFMNVPK Q6PF96 2 2161.152 4.03 oxidoreductase, C11(Carbamidomethyl); K20(Dimethyl) mitochondrial Electron transfer N-Term(Dimethyl:2H(6)13C(2)); flavoprotein-ubiquinone LTFPGGLLIGCSPGFMNVPK Q6PF96 C11(Carbamidomethyl); 2 2177.245 3.81 oxidoreductase, K20(HeavyDimethyl) mitochondrial LTGALAGGGSAAGTSANATKTSPASG Isoform 2 of Protein Q8C3Q5-2 K20(HeavyDimethyl) 1 2739.431 2.88 TGAAAR shisa-7 N-Term(Dimethyl); K5(Dimethyl); LTGIKHELQANCYEEVKDR P18760 Cofilin-1 3 2387.236 2.94 C12(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K5(HeavyDimethyl); LTGIKHELQANCYEEVKDR P18760 Cofilin-1 1 2411.360 2.86 C12(Carbamidomethyl); K17(HeavyDimethyl) LTGQIFLGGSIVRGGSVQVLEDQELTC Selenium-binding N-Term(Dimethyl); G3UYY2 1 3823.064 4.87 QPEPLVVK protein 2 C27(Carbamidomethyl); K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LTGQIFLGGSIVRGGSVQVLEDQELTC Selenium-binding G3UYY2 C27(Carbamidomethyl); 1 3839.166 5.81 QPEPLVVK protein 2 K35(HeavyDimethyl) Serine/threonine-protein N-Term(Dimethyl); M5(Oxidation); LTHNMVNGMGPMGTEGLFR Q9JKK8 2 2137.967 2.61 kinase ATR M9(Oxidation); M12(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); C10(Carbamidomethyl); C15(Carbamidomethyl); LTIPCRALTCSHLQCFDATLYIQMNEK E3 SUMO-protein ligase O88907 K27(HeavyDimethyl); 1 4798.485 2.70 KPTWVCPVCDK PIAS1 K28(HeavyDimethyl); C33(Carbamidomethyl); C36(Carbamidomethyl); K38(HeavyDimethyl) N-Term(Dimethyl); LTLLEVGCGTGANFK H3BJI7 Protein Mettl7a2Higd1c 1 1635.879 2.41 C8(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LTLLEVGCGTGANFK H3BJI7 Protein Mettl7a2Higd1c C8(Carbamidomethyl); 2 1651.965 2.83 K15(HeavyDimethyl) LTLTAQDGGSLPRSGTTEVHIEVLDIN Q91Y03 MCG141291 K39(HeavyDimethyl) 1 4353.228 3.10 DNAPQFEQLFYK LTLVPTVEAGLMSQASRPEQSVMQAL Q3TPJ7-3 Isoform 3 of Midnolin M23(Oxidation) 2 4391.242 2.95 ESLTETQPPATPGPGR Glutamyl LTMEFKGWLNGSLVGFYKTTYMEDG K6(HeavyDimethyl); F7B9G4 aminopeptidase 1 3372.763 3.61 QIR K18(HeavyDimethyl); M22(Oxidation) (Fragment) Spermatogenesis- LTPGDNPYMFPEQSK A2RRY8 associated serine-rich K15(Dimethyl) 1 1751.845 2.27 protein 1 Folliculin-interacting LTRSASFFAAHSTPVDMPSR D3YUC5 N-Term(Dimethyl); M17(Oxidation) 1 2222.109 2.24 protein 2 N-Term(Dimethyl:2H(6)13C(2)); K8(HeavyDimethyl); LTSVESPKDGCHFSNSSCSFQVSSQILY O35309 N-myc-interactor C11(Carbamidomethyl); 1 4759.438 3.18 ELQEGQALITFEK C18(Carbamidomethyl); K41(HeavyDimethyl) LTTPRNSLTLPSIPAGISNMAVGDMSS M25(Oxidation); M28(Oxidation); Q0VGT2 Zinc finger protein GLI2 1 3887.945 3.05 MLTSLAEESK K37(HeavyDimethyl) LTTPTYGDLNHLVSATMSGVTTCLRFP N-Term(Dimethyl); P99024 Tubulin beta-5 chain 1 3847.944 3.11 GQLNADLR C23(Carbamidomethyl) LTTPTYGDLNHLVSATMSGVTTCLRFP N-Term(Dimethyl:2H(6)13C(2)); P99024 Tubulin beta-5 chain 1 3856.021 3.27 GQLNADLR C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LTTPTYGDLNHLVSATMSGVTTCLRFP P99024 Tubulin beta-5 chain C23(Carbamidomethyl); 1 4020.160 3.81 GQLNADLRK K36(HeavyDimethyl) N-Term(Dimethyl); LTVVDTPGYGDAINCR F6UKN5 Septin-2 (Fragment) 4 1778.873 3.06 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LTVVDTPGYGDAINCR F6UKN5 Septin-2 (Fragment) 1 1786.906 2.13 C15(Carbamidomethyl) LTYYGYEFINLNEDLSSWTAQGEAAGF Histocompatibility 2, M N-Term(Dimethyl:2H(6)13C(2)); Q85ZW9 2 3372.763 3.27 LK region locus 10.2 K29(HeavyDimethyl) 2-amino-3-ketobutyrate N-Term(Dimethyl); LVATDGAFSMDGDIAPLQDICR E9PWY6 coenzyme A ligase, 6 2393.163 5.13 C21(Carbamidomethyl) mitochondrial

2-amino-3-ketobutyrate N-Term(Dimethyl); M10(Oxidation); LVATDGAFSMDGDIAPLQDICR E9PWY6 coenzyme A ligase, 1 2409.167 2.72 C21(Carbamidomethyl) mitochondrial

2-amino-3-ketobutyrate N-Term(Dimethyl:2H(6)13C(2)); LVATDGAFSMDGDIAPLQDICR E9PWY6 coenzyme A ligase, 2 2401.204 4.30 C21(Carbamidomethyl) mitochondrial N-Term(Dimethyl); LVCISDYEQHVR Q9WU19 Hydroxyacid oxidase 1 3 1546.764 3.29 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LVCISDYEQHVR Q9WU19 Hydroxyacid oxidase 1 4 1554.807 3.08 C3(Carbamidomethyl) Dimethylglycine N-Term(Dimethyl); LVCLTVATDDVDPEGNESIWYKGK Q9DBT9 dehydrogenase, C3(Carbamidomethyl); K22(Dimethyl); 3 2793.408 3.88 mitochondrial K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dimethylglycine C3(Carbamidomethyl); LVCLTVATDDVDPEGNESIWYKGK Q9DBT9 dehydrogenase, 2 2817.549 4.52 K22(HeavyDimethyl); mitochondrial K24(HeavyDimethyl) Leptin receptor N-Term(Dimethyl:2H(6)13C(2)); LVDDTDAMSNACKELAIFLTTGIVVSA Q9CQ74 overlapping transcript- M8(Oxidation); C12(Carbamidomethyl); 1 3929.175 3.22 FGLPVVFAR like 1 K13(HeavyDimethyl)

Long-chain-fatty-acid-- N-Term(Dimethyl); K13(Dimethyl); LVDVEEMNYLASKGEGEVCVK D3Z041 1 2453.229 2.41 CoA ligase 1 C19(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- K13(HeavyDimethyl); LVDVEEMNYLASKGEGEVCVK D3Z041 1 2477.373 2.31 CoA ligase 1 C19(Carbamidomethyl); K21(HeavyDimethyl) 2-hydroxyacyl-CoA N-Term(Dimethyl); LVEQCSLPFLPTPMGK D3YZ54 5 1872.994 3.35 lyase 1 C5(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-hydroxyacyl-CoA LVEQCSLPFLPTPMGK D3YZ54 C5(Carbamidomethyl); 1 1889.070 3.50 lyase 1 K16(HeavyDimethyl) Hydroxyacyl-coenzyme N-Term(Dimethyl); K6(Dimethyl); LVEVIKTPMTSQKTFESLVDFCK Q61425 A dehydrogenase, K13(Dimethyl); C22(Carbamidomethyl); 2 2812.525 3.24 mitochondrial K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxyacyl-coenzyme K6(HeavyDimethyl); LVEVIKTPMTSQKTFESLVDFCK Q61425 A dehydrogenase, K13(HeavyDimethyl); 2 2844.714 3.13 mitochondrial C22(Carbamidomethyl); K23(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); LVEYCQR Q8R0Y6 formyltetrahydrofolate 1 1003.542 1.92 C5(Carbamidomethyl) dehydrogenase 60S ribosomal protein N-Term(Dimethyl); LVILANNCPALR P62889 15 1381.798 3.60 L30 C8(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); LVILANNCPALR P62889 7 1389.843 3.10 L30 C8(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); LVILANNCPALRK P62889 1 1537.924 2.79 L30 C8(Carbamidomethyl); K13(Dimethyl) Betaine--homocysteine S-N-Term(Dimethyl); K3(Dimethyl); LVKAGASIVGVNCHFDPSVSLQTVK O35490 8 2710.481 5.86 methyltransferase 1 C13(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S-K3(HeavyDimethyl); LVKAGASIVGVNCHFDPSVSLQTVK O35490 8 2734.629 4.42 methyltransferase 1 C13(Carbamidomethyl); K25(HeavyDimethyl) N-Term(Dimethyl); K3(Dimethyl); Electron transfer LVKEIIAVSCGPSQCQETIR Q9DCW4 C10(Carbamidomethyl); 13 2344.235 5.39 flavoprotein subunit beta C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Electron transfer K3(HeavyDimethyl); LVKEIIAVSCGPSQCQETIR Q9DCW4 21 2360.324 5.39 flavoprotein subunit beta C10(Carbamidomethyl); C15(Carbamidomethyl) N-Term(Dimethyl); LVLCEVFK P15105 Glutamine synthetase 2 1063.624 2.27 C4(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl); LVNADGEAVYCK P24270 Catalase 9 1394.694 3.77 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LVNADGEAVYCK P24270 Catalase C11(Carbamidomethyl); 3 1410.783 3.59 K12(HeavyDimethyl) N-Term(Dimethyl); LVNADGEAVYCKFHYK P24270 Catalase C11(Carbamidomethyl); K12(Dimethyl); 2 1998.012 3.29 K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); LVNADGEAVYCKFHYK P24270 Catalase 1 2022.142 3.37 K12(HeavyDimethyl); K16(HeavyDimethyl) N-Term(Dimethyl); LVNADGEAVYCKFHYKTDQGIK P24270 Catalase C11(Carbamidomethyl); K12(Dimethyl); 3 2668.365 3.17 K16(Dimethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); LVNADGEAVYCKFHYKTDQGIK P24270 Catalase K12(HeavyDimethyl); 1 2700.546 2.62 K16(HeavyDimethyl); K22(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl); LVNGCALNFFR Q9DCJ5 [ubiquinone] 1 alpha 1 1338.695 2.59 C5(Carbamidomethyl) subcomplex subunit 8

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); LVNGCALNFFR Q9DCJ5 [ubiquinone] 1 alpha 3 1346.733 2.39 C5(Carbamidomethyl) subcomplex subunit 8

LVPRLSAVSSRPTTPPVAPPQAVSGPN Transcription initiation Q6NZA9 N-Term(Dimethyl); K28(Dimethyl) 1 3977.207 3.65 KAATPVSVTSQR factor TFIID subunit 9B

N-Term(Dimethyl); K10(Dimethyl); LVQAFQFTDKHGEVCPAGWKPGSDTI P35700 Peroxiredoxin-1 C15(Carbamidomethyl); K20(Dimethyl); 1 3709.934 3.46 KPDVNK K27(Dimethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K10(HeavyDimethyl); LVQAFQFTDKHGEVCPAGWKPGSDTI C15(Carbamidomethyl); P35700 Peroxiredoxin-1 3 3750.145 4.17 KPDVNK K20(HeavyDimethyl); K27(HeavyDimethyl); K32(HeavyDimethyl) 60 kDa heat shock LVQDVANNTNEEAGDGTTTATVLAR P63038 N-Term(Dimethyl) 2 2588.281 3.51 protein, mitochondrial N-Term(Dimethyl); K10(Dimethyl); LVQEVTDFAKTCVADESAANCDK P07724 Serum albumin C12(Carbamidomethyl); 1 2655.262 3.53 C21(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K10(HeavyDimethyl); LVQEVTDFAKTCVADESAANCDK P07724 Serum albumin C12(Carbamidomethyl); 1 2679.385 3.00 C21(Carbamidomethyl); K23(HeavyDimethyl) N-Term(Dimethyl); Heat shock protein HSP LVSSPCCIVTSTYGWTANMER P11499 C6(Carbamidomethyl); 13 2460.131 4.53 90-beta C7(Carbamidomethyl) N-Term(Dimethyl); Heat shock protein HSP LVSSPCCIVTSTYGWTANMER P11499 C6(Carbamidomethyl); 2 2476.130 3.93 90-beta C7(Carbamidomethyl); M19(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP LVSSPCCIVTSTYGWTANMER P11499 C6(Carbamidomethyl); 16 2468.180 5.12 90-beta C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP LVSSPCCIVTSTYGWTANMER P11499 C6(Carbamidomethyl); 6 2484.173 4.29 90-beta C7(Carbamidomethyl); M19(Oxidation) N-Term(Dimethyl); Heat shock protein HSP LVTSPCCIVTSTYGWTANMER P07901 C6(Carbamidomethyl); 3 2474.156 4.44 90-alpha C7(Carbamidomethyl) N-Term(Dimethyl); Heat shock protein HSP LVTSPCCIVTSTYGWTANMER P07901 C6(Carbamidomethyl); 2 2490.142 4.23 90-alpha C7(Carbamidomethyl); M19(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP LVTSPCCIVTSTYGWTANMER P07901 C6(Carbamidomethyl); 6 2482.195 5.35 90-alpha C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP LVTSPCCIVTSTYGWTANMER P07901 C6(Carbamidomethyl); 2 2498.181 3.63 90-alpha C7(Carbamidomethyl); M19(Oxidation) Poly(rC)-binding protein N-Term(Dimethyl); LVVPASQCGSLIGK E9Q7D8 1 1484.848 2.30 3 C8(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Poly(rC)-binding protein LVVPATQCGSLIGK P60335 C8(Carbamidomethyl); 2 1514.954 2.36 1 K14(HeavyDimethyl)

N-Term(Dimethyl); Poly(rC)-binding protein LVVPATQCGSLIGKGGCK P60335 C8(Carbamidomethyl); K14(Dimethyl); 1 1929.059 2.45 1 C17(Carbamidomethyl); K18(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C8(Carbamidomethyl); Poly(rC)-binding protein LVVPATQCGSLIGKGGCK P60335 K14(HeavyDimethyl); 4 1953.195 2.89 1 C17(Carbamidomethyl); K18(HeavyDimethyl) Acyl-coenzyme A synthetase ACSM1, N-Term(Dimethyl); LVVSDHSHEGWLDFCSLIK D3Z106 1 2298.159 2.56 mitochondrial C15(Carbamidomethyl); K19(Dimethyl) (Fragment) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); synthetase ACSM1, LVVSDHSHEGWLDFCSLIK D3Z106 C15(Carbamidomethyl); 1 2314.248 3.10 mitochondrial K19(HeavyDimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); LVYYEGGPVCTHARSLWRLEPLR K3W4M2 Ryanodine receptor 1 1 2808.506 2.59 C10(Carbamidomethyl) Isoform 2 of Enoyl-CoA N-Term(Dimethyl); LYAVNAEECTTLQAR Q9WUR2-2 delta isomerase 2, 2 1766.864 2.72 C9(Carbamidomethyl) mitochondrial Isoform 2 of Enoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); LYAVNAEECTTLQAR Q9WUR2-2 delta isomerase 2, 4 1774.914 2.74 C9(Carbamidomethyl) mitochondrial LYFDEISFEVVMDIYELENPEGVILSMG Isoform 2 of CAD N-Term(Dimethyl:2H(6)13C(2)); B2RQC6-2 1 4737.338 3.19 GQLPNNMAMALHR protein M37(Oxidation) Eukaryotic translation N-Term(Dimethyl); LYFLQCETCHSR Q99L45 initiation factor 2 C6(Carbamidomethyl); 1 1641.747 2.33 subunit 2 C9(Carbamidomethyl) Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); LYFLQCETCHSR Q99L45 initiation factor 2 C6(Carbamidomethyl); 1 1649.788 2.19 subunit 2 C9(Carbamidomethyl) Trafficking protein K9(HeavyDimethyl); LYGDFLSWKLEETLAQFPLQPGK E9PZ41 particle complex subunit 2 2752.521 2.77 K23(HeavyDimethyl) 9 LYLGHNYVTAIRNQQEGVCPEGSIDNS N-Term(Dimethyl); Q921I1 Serotransferrin 1 3414.750 3.99 PVK C19(Carbamidomethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); LYLGHNYVTAIRNQQEGVCPEGSIDNS Q921I1 Serotransferrin C19(Carbamidomethyl); 2 3430.793 4.69 PVK K30(HeavyDimethyl) Nicotinate N-Term(Dimethyl); LYLQQGQLCEPLPSLDESR Q8CC86 phosphoribosyltransferas 1 2274.149 3.24 C9(Carbamidomethyl) e Nicotinate N-Term(Dimethyl); LYLQQGQLCEPLPSLDESRR Q8CC86 phosphoribosyltransferas 1 2430.248 3.01 C9(Carbamidomethyl) e Nicotinate N-Term(Dimethyl:2H(6)13C(2)); LYLQQGQLCEPLPSLDESRR Q8CC86 phosphoribosyltransferas 1 2438.312 2.30 C9(Carbamidomethyl) e Mitochondrial LYPSESYLQNYEVAYPDCSPVHLISEAS N-Term(Dimethyl); Q922Q1 amidoxime reducing 3 4070.984 5.30 LVDLNTR C18(Carbamidomethyl) component 2 Mitochondrial LYPSESYLQNYEVAYPDCSPVHLISEAS N-Term(Dimethyl:2H(6)13C(2)); Q922Q1 amidoxime reducing 4 4079.013 6.13 LVDLNTR C18(Carbamidomethyl) component 2 N-Term(Dimethyl); LYQSCADPTGCGTGSDAR Q9ET22 Dipeptidyl peptidase 2 C5(Carbamidomethyl); 4 1943.817 3.13 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); LYQSCADPTGCGTGSDAR Q9ET22 Dipeptidyl peptidase 2 C5(Carbamidomethyl); 2 1951.859 2.90 C11(Carbamidomethyl) LYQVEYAMEAIGHAGTCLGILANDGV Proteasome subunit N-Term(Dimethyl:2H(6)13C(2)); E9PW69 5 3610.891 3.65 LLAAERR alpha type (Fragment) C17(Carbamidomethyl) Alanine--tRNA ligase, N-Term(Dimethyl); LYVTYFGGDEAAGLEPDLECR Q8BGQ7 4 2403.108 3.99 cytoplasmic C20(Carbamidomethyl) Alanine--tRNA ligase, N-Term(Dimethyl:2H(6)13C(2)); LYVTYFGGDEAAGLEPDLECR Q8BGQ7 5 2411.162 3.89 cytoplasmic C20(Carbamidomethyl) Very-long-chain (3R)-3- MAAAAATAATKGNGGGSGRVGAGDS hydroxyacyl-[acyl- Q9D3B1 K11(HeavyDimethyl) 1 2513.268 2.52 SGAR carrier protein] dehydratase 2 Isoform 2 of Histone- MAAAAGAAAAAAAEGEAPAEMGALL lysine N- Q9Z148-2 M1(Oxidation); K28(Dimethyl) 1 3437.723 3.08 LEKEPRGAAER methyltransferase EHMT2 MAAAVAAAAAAAAAAASFQVLEMES N-Term(Dimethyl:2H(6)13C(2)); Q8CE33 Kelch-like protein 11 1 3890.009 3.02 METAVAGSASLAAEVR M23(Oxidation) MAAAYLDPNLNHTPSSSTKTHLGTGM Isoform 8 of Focal P34152-8 K19(HeavyDimethyl) 1 3036.529 2.23 ER adhesion kinase 1 N-Term(Dimethyl); MAAISESNINLCGSHCGVSIGEDGPSQ P40142 Transketolase C12(Carbamidomethyl); 3 3995.830 4.64 MALEDLAMFR C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MAAISESNINLCGSHCGVSIGEDGPSQ P40142 Transketolase C12(Carbamidomethyl); 1 4003.868 4.08 MALEDLAMFR C16(Carbamidomethyl) GTPase Era, N-Term(Dimethyl); MAAPRRYCAGLVR Q9CZU4 2 1548.809 2.25 mitochondrial C8(Carbamidomethyl) MAASLNAGETTYNLEHANDLRVEVQ Q80Y56 Rabenosyn-5 K26(Dimethyl); K36(Dimethyl) 1 4062.140 3.49 KVYELIDALSK N-Term(Dimethyl); MACEDQFTNLVPQTDSK G3X982 Aldehyde oxidase 3 12 2039.940 4.72 C3(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); MACEDQFTNLVPQTDSK G3X982 Aldehyde oxidase 3 C3(Carbamidomethyl); 5 2056.034 4.37 K17(HeavyDimethyl) Propionyl-CoA N-Term(Dimethyl); MADEAVCVGPAPTSK Q91ZA3 carboxylase alpha chain, 4 1588.765 4.04 C7(Carbamidomethyl); K15(Dimethyl) mitochondrial Propionyl-CoA N-Term(Dimethyl:2H(6)13C(2)); MADEAVCVGPAPTSK Q91ZA3 carboxylase alpha chain, C7(Carbamidomethyl); 1 1604.856 3.71 mitochondrial K15(HeavyDimethyl) Dihydropyrimidine N-Term(Dimethyl); MAEASGADALELNLSCPHGMGER Q8CHR6 dehydrogenase 1 2444.100 3.89 C16(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); MAEASGADALELNLSCPHGMGER Q8CHR6 dehydrogenase 1 2452.123 4.07 C16(Carbamidomethyl) [NADP(+)] FACT complex subunit N-Term(Dimethyl:2H(6)13C(2)); MAETLEFNDIFQEVKGSMNDGR A2AW05 1 2619.318 2.68 SSRP1 (Fragment) K15(HeavyDimethyl); M18(Oxidation) MAGAPRGQGGGGGAGEPGGAERAAG O88444 Adenylate cyclase type 1 2 2463.192 2.82 PGGR GTPase-activating N-Term(Dimethyl); K14(Dimethyl); MALDNLLANLPQAKPGKSSSLDMTPY protein and VPS9 F7ADS7 K17(Dimethyl); M31(Oxidation); 1 4315.199 3.11 STPQMSPATTPANK domain-containing K40(Dimethyl) protein 1 (Fragment) MAPPSEETPLIPQRSCSLSSSEAGALHV Tyrosine-protein kinase Q62137 M1(Oxidation); C16(Carbamidomethyl) 1 4233.159 2.79 LLPPRGPGPPQR JAK3 DnaJ homolog subfamily N-Term(Dimethyl:2H(6)13C(2)); MAPQNLSTFCLLLLYLIGTVIAGR Q99KV1 2 2700.538 2.85 B member 11 C10(Carbamidomethyl)

MARAAMEAAATVVLALALLGAAAR Q8VCN6 CD99 antigen 2 2312.304 2.57 MARATFDMNAAGLEARGGGHTEHGP Homeobox protein MSX- G3X9C7 N-Term(Dimethyl) 1 4053.006 2.87 LPFSVESLLEAER 3 N-Term(Dimethyl); MARPCAFLMVLVVLSYWSACSLGCDL C5(Carbamidomethyl); Q80SU4 Interferon alpha-13 1 3893.968 3.08 PQTHNLR C20(Carbamidomethyl); C24(Carbamidomethyl) COP9 signalosome MASALEQFVNSVRQLSAQGQMTQLCE M1(Oxidation); C25(Carbamidomethyl); D3Z036 complex subunit 3 1 3446.737 3.03 LINK K30(HeavyDimethyl) (Fragment) Isoform 2 of Dipeptidyl N-Term(Dimethyl:2H(6)13C(2)); MASASSSMWEAKPGTPASEGQR Q8BVG4-2 1 2354.160 2.45 peptidase 9 M8(Oxidation); K12(HeavyDimethyl) Microtubule-associated MASPPPSGPPSAAHTPFHQSPVEEK Q9QYR6 M1(Oxidation); K25(Dimethyl) 1 2627.265 2.75 protein 1A N-Term(Dimethyl:2H(6)13C(2)); MATVYPEPQNKEEFVSSQMYSTNYDQ NADP-dependent malic K11(HeavyDimethyl); P06801 1 4891.395 3.33 ILPDCYPWPAEVQK enzyme C31(Carbamidomethyl); K40(HeavyDimethyl) Carbamoyl-phosphate MCHPSVDGFTPR Q8C196 synthase [ammonia], C2(Carbamidomethyl) 4 1403.620 2.09 mitochondrial Carbamoyl-phosphate MCHPSVDGFTPR Q8C196 synthase [ammonia], M1(Oxidation); C2(Carbamidomethyl) 1 1419.610 1.96 mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); MCHPSVDGFTPR Q8C196 synthase [ammonia], 8 1431.644 3.11 C2(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); MCHPSVDGFTPR Q8C196 synthase [ammonia], 2 1439.690 2.98 C2(Carbamidomethyl) mitochondrial NADH-ubiquinone N-Term(Dimethyl); MCLVEIEKAPK Q91VD9 oxidoreductase 75 kDa C2(Carbamidomethyl); K8(Dimethyl); 1 1401.783 2.32 subunit, mitochondrial K11(Dimethyl) C2(Carbamidomethyl); M15(Oxidation); MCQDMAEPEVFSPNMCQETAVPQTYP Q9ERZ0 Hemogen C16(Carbamidomethyl); K28(Dimethyl); 1 4795.115 2.82 PKALEEMAAAEPLSPK K42(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); MCWTAGWGKTGEK P11034 Mast cell protease 1 1 1619.911 2.83 K9(HeavyDimethyl); K13(HeavyDimethyl) MDEGDAQSRAQQQLEAPSSVGAVQEK E9PVE0 Protein Slco5a1 N-Term(Dimethyl); K26(Dimethyl) 1 2815.363 3.05 Endoplasmic reticulum MDHLVCFLPGTLALGVHHGLPADHM mannosyl- A2AJ15 C6(Carbamidomethyl) 2 3193.606 2.80 DLAR oligosaccharide 1,2- alpha-mannosidase N-Term(Dimethyl); K11(Dimethyl); MDWNEILEGIKK E9PZG0 Protein Apol11a 1 1559.870 2.09 K12(Dimethyl) C8(Carbamidomethyl); MEADGLGCAVCVLTGASR Q64105 Sepiapterin reductase 2 1866.823 3.28 C11(Carbamidomethyl) MEAGEAAPPVGAGGRPGGGWGKWV E0CZ97 Protein Kctd17 M1(Oxidation); K22(Dimethyl) 1 2494.215 2.30 R N-Term(Dimethyl); PCTP-like protein MECCDVPAETLYDVLHDIEYR G3UY87 C3(Carbamidomethyl); 8 2656.181 4.62 (Fragment) C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); PCTP-like protein MECCDVPAETLYDVLHDIEYR G3UY87 C3(Carbamidomethyl); 7 2664.212 4.73 (Fragment) C4(Carbamidomethyl) Chromobox protein C16(Carbamidomethyl); MEELSSVGEQVFAAECILSK P30658 1 2263.121 2.39 homolog 2 K20(HeavyDimethyl) Isoform 2 of Mitotic spindle assembly MEGTSGLDVSTSASGSLQK Q9WTX8-2 N-Term(Dimethyl); K19(Dimethyl) 1 1910.964 2.32 checkpoint protein MAD1 Isoform 2 of WD repeat MEHLTDSRPEEPSTWSGYMGK Q8R3E3-2 domain phosphoinositide-K21(HeavyDimethyl) 1 2474.145 2.42 interacting protein 1

C4(Carbamidomethyl); MEICWGPYSHLISLLLILLFHSEAACRP Interleukin-1 receptor P25085 C26(Carbamidomethyl); K31(Dimethyl); 1 4196.204 3.12 SGKRPCK antagonist protein C34(Carbamidomethyl); K35(Dimethyl)

Rac GTPase-activating MEIINEGNESIEFIQVV E9Q1Y6 N-Term(Dimethyl:2H(6)13C(2)) 1 2000.034 2.17 protein 1 (Fragment)

N-Term(Dimethyl); K3(Dimethyl); MEKDEQIPDGMCIDAEGK Q64374 Regucalcin 2 2149.983 2.92 C12(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); MEKDEQIPDGMCIDAEGK Q64374 Regucalcin 1 2174.102 2.47 C12(Carbamidomethyl); K18(HeavyDimethyl) p21-activated protein MELVAGSYEQVLFGFTVQR Q9DCE5 kinase-interacting M1(Oxidation) 2 2190.082 2.38 protein 1 Calcium-transporting M1(Oxidation); K14(HeavyDimethyl); MENLLPPSGFSYLKK H3BIX7 ATPase type 2C member 1 1812.032 2.24 K15(HeavyDimethyl) 1 BEN domain-containing N-Term(Dimethyl:2H(6)13C(2)); MEPEMQAAEEGPSAPR P86174 1 1781.839 2.07 protein 4 M5(Oxidation) M9(Oxidation); M28(Oxidation); MEPSAGRPMDYQVSITVIEARQLVGLN D3YXV0 Otoferlin (Fragment) C33(Carbamidomethyl); 1 4486.211 3.21 MDPVVCVEVGDDK K40(HeavyDimethyl) D-beta-hydroxybutyrate METYCNSGSTDTSSVINAVTHALTAAT N-Term(Dimethyl); Q80XN0 dehydrogenase, 2 3347.545 3.97 PYTR C5(Carbamidomethyl) mitochondrial

D-beta-hydroxybutyrate METYCNSGSTDTSSVINAVTHALTAAT N-Term(Dimethyl:2H(6)13C(2)); Q80XN0 dehydrogenase, 4 3355.597 6.21 PYTR C5(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- MFEPKCLDAFPNLR P10649 K5(HeavyDimethyl); 1 1809.999 2.49 transferase Mu 1 C6(Carbamidomethyl) C13(Carbamidomethyl); Isoform 2 of Anoctamin- MFLFQFVNYYSSCFYIAFFKGK Q6P9J9-2 K20(HeavyDimethyl); 1 2879.477 2.25 6 K22(HeavyDimethyl) Isoform 3 of Serine/threonine-protein MFTIMMTNNVLPVQRAAAR Q8C0Y0-3 M6(Oxidation) 2 2180.128 2.45 phosphatase 4 regulatory subunit 4 Delta(3,5)-Delta(2,4)- MFTSGIDLMDMASELMQPSGDDAARI M11(Oxidation); M16(Oxidation); O35459 dienoyl-CoA isomerase, 1 4115.969 3.05 AWYLRDLISK K36(HeavyDimethyl) mitochondrial Formimidoyltransferase- N-Term(Dimethyl); MGALDVCPFIPVR Q91XD4 1 1502.790 2.14 cyclodeaminase C7(Carbamidomethyl) Acyl-CoA synthetase N-Term(Dimethyl); MGEEICACIR Q8VCW8 family member 2, C6(Carbamidomethyl); 1 1266.560 2.44 mitochondrial C8(Carbamidomethyl) Acyl-CoA synthetase N-Term(Dimethyl:2H(6)13C(2)); MGEEICACIR Q8VCW8 family member 2, C6(Carbamidomethyl); 1 1274.608 2.13 mitochondrial C8(Carbamidomethyl) Acetyl-CoA N-Term(Dimethyl:2H(6)13C(2)); MGEVPLADSILCDGLTDAFHNYHMGI G3XA25 acetyltransferase, C12(Carbamidomethyl); 1 3661.835 3.48 TAENVAK cytosolic K33(HeavyDimethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); MGFCSVQEDINSLCLTVVQR P54869 CoA synthase, C4(Carbamidomethyl); 4 2384.145 4.94 mitochondrial C14(Carbamidomethyl) Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); MGFCSVQEDINSLCLTVVQR P54869 CoA synthase, C4(Carbamidomethyl); 7 2392.200 5.41 mitochondrial C14(Carbamidomethyl) Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); MGFCSVQEDINSLCLTVVQRLMER P54869 CoA synthase, C4(Carbamidomethyl); 1 2921.469 3.46 mitochondrial C14(Carbamidomethyl) Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); MGFCSVQEDINSLCLTVVQRLMER P54869 CoA synthase, C4(Carbamidomethyl); 1 2937.453 2.75 mitochondrial C14(Carbamidomethyl); M22(Oxidation) Basement membrane- N-Term(Dimethyl:2H(6)13C(2)); specific heparan sulfate MGKDITLECISSGEPR B1B0C7 K3(HeavyDimethyl); 1 1865.010 2.75 proteoglycan core C9(Carbamidomethyl) protein MGLLVGDDLWAVVIFTAIFLLLVDLV Q8CIM7 Cytochrome P450 2D26 N-Term(Dimethyl) 1 3166.797 2.95 HR C10(Carbamidomethyl); MGLTTLPGACSRCCAEGRALYSPAETL Protein Plekhg1 F7CES2 C13(Carbamidomethyl); 1 3484.569 2.84 EHLY (Fragment) C14(Carbamidomethyl) MGMGNSYSGGYGAPDGLGGYGRGGG MCG11326, isoform D3YWT1 N-Term(Dimethyl); M44(Oxidation) 1 4304.773 3.07 GSGGYYGQGGMSGGGWRGMY CRA_b NADH dehydrogenase [ubiquinone] 1 alpha N-Term(Dimethyl); MGSQVIIPYRCDVYDIMHLR Q9DC69 1 2494.246 3.12 subcomplex subunit 9, C11(Carbamidomethyl) mitochondrial MHLALYSLAIFVVVTVHFGAQDILTLY Proton-coupled folate N-Term(Dimethyl); Q6PEM8 1 4377.245 3.20 ELSAPLCWDSK transporter C34(Carbamidomethyl); K38(Dimethyl) N-Term(Dimethyl); MHSVGICGSDVHYWEHGR Q64442 Sorbitol dehydrogenase 3 2154.958 4.90 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MHSVGICGSDVHYWEHGR Q64442 Sorbitol dehydrogenase 4 2162.999 4.13 C7(Carbamidomethyl) Probable ATP- MIDMLAANSGRVTNLRR Q569Z5 dependent RNA helicase 1 1918.035 2.21 DDX46 Isoform 3 of U2 snRNP- MIEFVVREGPMFEAMIMNREINNPMFR Q6NV83-3 associated SURP motif- M17(Oxidation) 2 3317.546 2.93 containing protein MCG21756, isoform MIHMSIQMGNEPPISLR B9EJ54 M4(Oxidation); M8(Oxidation) 1 1985.966 2.19 CRA_b N-Term(Dimethyl:2H(6)13C(2)); Isoform 4 of Ecto-ADP- MILEDLLMVLSCLSLHALWKVR P70352-4 M8(Oxidation); C12(Carbamidomethyl); 1 2728.598 3.61 ribosyltransferase 5 K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glucose-6-phosphate MIPCDFLIPVQTQHPIRK F6SAC3 C4(Carbamidomethyl); 1 2265.319 2.59 isomerase K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); MISGRPAMDIPPIHPGMIPPKPLIR S4R294 Protein PRRC2C 1 2822.658 2.68 M17(Oxidation); K21(HeavyDimethyl) N-Term(Dimethyl); MISQSCLSNIEKHEFIMR Q8BGL3 Protein 2810007J24Rik 1 2279.146 3.04 C6(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); MISQSCLSNIEKHEFIMR Q8BGL3 Protein 2810007J24Rik C6(Carbamidomethyl); 1 2295.219 2.59 K12(HeavyDimethyl) N-Term(Dimethyl); Fatty acid-binding MIVECVMNNATCTR Q05816 C5(Carbamidomethyl); 2 1726.767 3.75 protein, epidermal C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty acid-binding MIVECVMNNATCTR Q05816 C5(Carbamidomethyl); 3 1734.819 3.15 protein, epidermal C12(Carbamidomethyl) M1(Oxidation); K2(HeavyDimethyl); MKCSSMQKFGER P07724 Serum albumin C3(Carbamidomethyl); M6(Oxidation); 1 1592.805 1.96 K8(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); MKCSSMQKFGER P07724 Serum albumin 2 1572.763 2.79 C3(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Isoform 2 of K4(HeavyDimethyl); MKGKCLLEVTGVADPTGCGEGFSYVK Q80UV9-2 Transcription initiation 1 2947.627 2.83 C5(Carbamidomethyl); factor TFIID subunit 1 C18(Carbamidomethyl); K26(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); K2(Dimethyl); MKLNISFPATGCQK P62754 3 1678.904 2.93 S6 C12(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl); K2(Dimethyl); MKTFSTCGSHLAVVTIYYGTMISMYV Q5NCD0 Olfactory receptor C7(Carbamidomethyl); M24(Oxidation); 1 4417.250 3.15 RPNAHLSPELNK K38(Dimethyl) Isoform 2 of Swi5- dependent MKVENDENNETLSEPGESSK Q8BP27-2 K2(Dimethyl); K20(Dimethyl) 2 2293.059 2.30 recombination DNA repair protein 1 homolog N-Term(Dimethyl); MLALGITGPEGHELCRPEAVEAEATLR Q9EQF5 Dihydropyrimidinase 4 2948.500 3.06 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MLALGITGPEGHELCRPEAVEAEATLR Q9EQF5 Dihydropyrimidinase 1 2956.554 2.64 C15(Carbamidomethyl) Very long-chain-specific N-Term(Dimethyl); acyl-CoA MLCDSWCIEAATR B1AR28 C3(Carbamidomethyl); 1 1640.742 2.62 dehydrogenase, C7(Carbamidomethyl) mitochondrial Very long-chain-specific N-Term(Dimethyl:2H(6)13C(2)); acyl-CoA MLCDSWCIEAATR B1AR28 C3(Carbamidomethyl); 2 1648.768 2.45 dehydrogenase, C7(Carbamidomethyl) mitochondrial M1(Oxidation); C5(Carbamidomethyl); Spectrin alpha chain, MLDQCLELQLFRGKCDQVESWMVAR P08032 K14(HeavyDimethyl); 1 3164.558 3.08 erythrocytic 1 C15(Carbamidomethyl) NADH-ubiquinone N-Term(Dimethyl); MLFLLGADGGCITR Q91VD9 oxidoreductase 75 kDa 4 1551.807 2.83 C11(Carbamidomethyl) subunit, mitochondrial NADH-ubiquinone N-Term(Dimethyl:2H(6)13C(2)); MLFLLGADGGCITR Q91VD9 oxidoreductase 75 kDa 2 1559.850 3.07 C11(Carbamidomethyl) subunit, mitochondrial MLKLLLLTLPLLSSLVHAAPGPAMTRE M1(Oxidation); K3(Dimethyl); Q02844-2 Isoform 2 of Tryptase 1 4105.332 2.95 GIVGGQEAHGNK K39(Dimethyl) N-Term(Dimethyl); K11(Dimethyl); MLLADQGQSWKEEVVTIDTWMQGLL Glutathione S- P19157 K26(Dimethyl); C29(Carbamidomethyl); 4 4289.242 4.83 KPTCLYGQLPK transferase P 1 K36(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K11(HeavyDimethyl); MLLADQGQSWKEEVVTIDTWMQGLL Glutathione S- P19157 K26(HeavyDimethyl); 2 4321.427 3.60 KPTCLYGQLPK transferase P 1 C29(Carbamidomethyl); K36(HeavyDimethyl) MLLVYDLHLSPKLWALATPQK Q8BN59 La-related protein 6 K12(Dimethyl); K21(Dimethyl) 2 2493.401 2.89 N-Term(Dimethyl); K5(Dimethyl); MLPDKDCR P18760 Cofilin-1 2 1090.535 2.45 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MLPDKDCR P18760 Cofilin-1 K5(HeavyDimethyl); 2 1106.624 2.34 C7(Carbamidomethyl) N-Term(Dimethyl); MLQGTCGAPIDPTIYLSK P56593 Cytochrome P450 2A12 5 2021.043 4.46 C6(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); MLQGTCGAPIDPTIYLSK P56593 Cytochrome P450 2A12 C6(Carbamidomethyl); 1 2037.133 3.47 K18(HeavyDimethyl) Cyclin-dependent kinase MLQINADPHYFTQVFSDLK P61809 K19(Dimethyl) 1 2295.116 2.51 5 activator 1 60S ribosomal protein N-Term(Dimethyl); MLSCAGADRLQTGMR I7HLV2 3 1694.807 2.70 L10 (Fragment) C4(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); MLSCAGADRLQTGMR I7HLV2 1 1702.861 2.23 L10 (Fragment) C4(Carbamidomethyl) MLSDYGTTFVAAWKNTHNYRVWNSN Late secretory pathway M1(Oxidation); K14(Dimethyl); Q80U56 1 3175.565 2.78 K protein AVL9 homolog K26(Dimethyl)

N-Term(Dimethyl); MLSLAEQQLVDCAQAFNNHGCK P49935 Pro-cathepsin H C12(Carbamidomethyl); 1 2590.224 3.61 C21(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C12(Carbamidomethyl); MLSLAEQQLVDCAQAFNNHGCK P49935 Pro-cathepsin H 2 2606.308 3.33 C21(Carbamidomethyl); K22(HeavyDimethyl) Retinol dehydrogenase N-Term(Dimethyl); MLSSGVCTSNVQLPGK Q9R1R8 1 1733.894 2.51 11 C7(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Retinol dehydrogenase MLSSGVCTSNVQLPGK Q9R1R8 C7(Carbamidomethyl); 1 1749.978 2.26 11 K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K21(HeavyDimethyl); MLTPFELVQFDIETAEPLRDKQGFCIPV Bile acyl-CoA Q4LDG0 C25(Carbamidomethyl); 1 4571.678 3.24 EPGKPGLLLTK synthetase K32(HeavyDimethyl); K39(HeavyDimethyl) Glutamate N-Term(Dimethyl); M2(Oxidation); MMEYGTTMVSYQPLGDK P48320 1 2038.941 2.51 decarboxylase 2 M8(Oxidation); K17(Dimethyl) MMLPPECSHLLVEEYMGDTEDPETLQ Isoform 2 of Pyrethroid N-Term(Dimethyl); Q8QZR3-2 2 3594.640 3.05 AQFR hydrolase Ces2a C7(Carbamidomethyl)

MMLPPECSHLLVEEYMGDTEDPETLQ Isoform 2 of Pyrethroid N-Term(Dimethyl:2H(6)13C(2)); Q8QZR3-2 1 3602.667 3.02 AQFR hydrolase Ces2a C7(Carbamidomethyl) Transmembrane protein MMLYPVLSLATVNVVAVLAR Q80XA0 N-Term(Dimethyl:2H(6)13C(2)) 1 2196.301 2.19 121

N-Term(Dimethyl:2H(6)13C(2)); Lys-63-specific MMQGVQAVYLESDAFLVCLNHALSTE M2(Oxidation); C18(Carbamidomethyl); Q7M757 deubiquitinase BRCC36- 1 4967.505 3.08 KEEVMGLCIGQLNDHGR K27(HeavyDimethyl); M31(Oxidation); like C34(Carbamidomethyl)

M1(Oxidation); K6(Dimethyl); MMVANKPDKIQQAK Q9CWK8 Sorting nexin-2 1 1701.926 2.65 K9(Dimethyl); K14(Dimethyl) M2(Oxidation); K6(Dimethyl); MMVANKPDKIQQAK Q9CWK8 Sorting nexin-2 1 1701.932 2.46 K9(Dimethyl); K14(Dimethyl) MMYYLAQYRGGTISVEAMVMALFEL M2(Oxidation); M18(Oxidation); Q80VW5-7 Isoform 7 of Whirlin 1 4551.350 2.84 LNTHAKFSLLSEVR K31(HeavyDimethyl) MNFYSPPTLMELARQCLLRDEYLAISA M10(Oxidation); Q7TPX8 Oogenesin 2 1 3487.821 3.07 LK C16(Carbamidomethyl); K29(Dimethyl) MNNKARVPAPSSVR Q5FWB9 Protein BC089491 M1(Oxidation); K4(HeavyDimethyl) 1 1578.890 2.00 N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); MNVCVSKQPAIMPGQSYGLEDGSCSY Heterogeneous nuclear G3UY38 K7(HeavyDimethyl); 1 3835.881 3.65 KDFSESR ribonucleoprotein L C24(Carbamidomethyl); K27(HeavyDimethyl)

C3(Carbamidomethyl); M19(Oxidation); MPCSFYIAGFLQSLNAELMGPVDCSQG E9Q1Z7 Protein Gm10855 C24(Carbamidomethyl); 1 4109.936 2.58 TFGSMNQKR M32(Oxidation); K35(HeavyDimethyl)

Isoform 2 of MPGMMWTPELALLRGFSTEAER Q8CD92-2 Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)) 1 2559.331 2.88 protein 27 C8(Carbamidomethyl); MPGSALLCCLLLLTGMRISRGQYSR P18893 Interleukin-10 2 2853.453 2.73 C9(Carbamidomethyl) MPHVQYIHTEASESLCGLKLEVNKYQ Metalloproteinase M1(Oxidation); C16(Carbamidomethyl); P39876 1 3849.974 3.23 YLLTGR inhibitor 3 K19(Dimethyl); K24(Dimethyl)

MPLLVSHLLLISLTSCLGDFTWHRR P12960 Contactin-1 M1(Oxidation); C16(Carbamidomethyl) 1 2981.603 2.61 Ribose-phosphate MPNIVLFSGSSHQDLSQR Q9CS42 M1(Oxidation) 2 2031.998 2.24 pyrophosphokinase 2 UDP- M1(Oxidation); M4(Oxidation); MPNMIFLGGINCK D3YZE6 glucuronosyltransferase C12(Carbamidomethyl); 1 1562.795 2.05 1-6 (Fragment) K13(HeavyDimethyl) MPSVNSGAMAPEIGLVIDGK B1AWN4 Protein Atp10b N-Term(Dimethyl); K20(Dimethyl) 1 2042.036 2.33 Solute carrier family 22 MPTFDQALRKAGEFGR Q9WTW5 N-Term(Dimethyl); K10(Dimethyl) 1 1879.982 2.43 member 3 MPYYYYFREMTVSVQEPMWLDIIK Q6NSQ5 Protein Sp140 M18(Oxidation); K24(Dimethyl) 1 3146.491 2.87 MQALLFLMALLLPSGAGAEEIIGGVES Mast cell protease-like M1(Oxidation); M8(Oxidation); Q00356 1 4947.633 2.67 EPHSRPYMAYVNTFRRK protein M35(Oxidation); K44(HeavyDimethyl)

MQAQNSAVQGGMIDSFMSIYQQEGTR Kidney mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Q9CR58 1 3449.684 2.63 GLWK carrier protein 1 M12(Oxidation); K30(HeavyDimethyl) M1(Oxidation); M7(Oxidation); MQEIEEMEKESGPGQK O70551 SRSF protein kinase 1 K9(HeavyDimethyl); 1 1953.972 2.22 K16(HeavyDimethyl) MQGASRLPNSTIYVVEAGYLGFTVYP Nuclear pore membrane Q9QY81 M1(Oxidation) 1 3177.574 2.23 GDR glycoprotein 210 Glutathione S- N-Term(Dimethyl); MQLIMLCYNPDFEK P10649 9 1857.891 4.34 transferase Mu 1 C7(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- MQLIMLCYNPDFEK P10649 C7(Carbamidomethyl); 12 1873.976 4.58 transferase Mu 1 K14(HeavyDimethyl) N-Term(Dimethyl); Glutathione S- MQLIMLCYNPDFEKQKPEFLK P10649 C7(Carbamidomethyl); K14(Dimethyl); 11 2784.459 4.91 transferase Mu 1 K16(Dimethyl); K21(Dimethyl)

N-Term(Dimethyl); M5(Oxidation); Glutathione S- MQLIMLCYNPDFEKQKPEFLK P10649 C7(Carbamidomethyl); K14(Dimethyl); 7 2800.449 3.61 transferase Mu 1 K16(Dimethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); Glutathione S- MQLIMLCYNPDFEKQKPEFLK P10649 K14(HeavyDimethyl); 8 2816.633 4.60 transferase Mu 1 K16(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); M5(Oxidation); C7(Carbamidomethyl); Glutathione S- MQLIMLCYNPDFEKQKPEFLK P10649 K14(HeavyDimethyl); 1 2832.633 3.32 transferase Mu 1 K16(HeavyDimethyl); K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); MQLSEIMERDAER Q8R3N1 Nucleolar protein 14 1 1659.823 2.31 M7(Oxidation) Isoform 2 of Eukaryotic N-Term(Dimethyl:2H(6)13C(2)); MQNWCPSWSDDEIICAR Q8BJW6-2 translation initiation C5(Carbamidomethyl); 1 2203.959 2.73 factor 2A C15(Carbamidomethyl) Non-canonical poly(A) MQSTQTTNTPNNANK F6UPY1 RNA polymerase N-Term(Dimethyl); K15(Dimethyl) 1 1705.806 2.31 PAPD5 (Fragment) Succinate dehydrogenase N-Term(Dimethyl); K10(Dimethyl); MQTYEVDLNKCGPMVLDALIK Q9CQA3 2 2522.291 3.32 [ubiquinone] iron-sulfur C11(Carbamidomethyl); K21(Dimethyl) subunit, mitochondrial

MQVVSLLLPSGTLPGSTMMPCNSTSHP M1(Oxidation); C21(Carbamidomethyl); Q8VF27 Olfactory receptor 654 1 4449.159 2.93 SFFILQGIPGMEDK K41(Dimethyl) Isoform 4 of Pleckstrin homology domain- MRALIYSTTTAGSQMEHSGMR Q3UIL6-4 M15(Oxidation) 1 2344.106 2.33 containing family A member 7 N-Term(Dimethyl); MRDCELLLQECIQQTTK Q99J08 SEC14-like protein 2 C4(Carbamidomethyl); 1 2222.118 2.50 C11(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); MRDCELLLQECIQQTTK Q99J08 SEC14-like protein 2 1 2238.193 3.36 C11(Carbamidomethyl); K17(HeavyDimethyl) MREENESSTIDFTLLGVTR Q7TRX2 MCG1036247 M1(Oxidation) 1 2214.083 2.28 N-Term(Dimethyl); MREIVHIQAGQCGNQIGAK P99024 Tubulin beta-5 chain 12 2166.121 4.40 C12(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); MREIVHIQAGQCGNQIGAK P99024 Tubulin beta-5 chain C12(Carbamidomethyl); 2 2182.209 2.40 K19(HeavyDimethyl) N-Term(Dimethyl); MREIVHLQAGQCGNQIGAK P99024 Tubulin beta-5 chain 4 2166.118 2.82 C12(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); MREIVHLQAGQCGNQIGAK P99024 Tubulin beta-5 chain C12(Carbamidomethyl); 8 2182.217 3.84 K19(HeavyDimethyl) Serine N-Term(Dimethyl); MREVCDEVRAHLLADMAHISGLVAAK Q9CZN7 hydroxymethyltransferas 1 2948.551 2.86 C5(Carbamidomethyl); K26(Dimethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); MREVCDEVRAHLLADMAHISGLVAAK Q9CZN7 hydroxymethyltransferas C5(Carbamidomethyl); 1 2964.628 3.31 e K26(HeavyDimethyl) Synaptotagmin-like MRQYPGSWAEGTLQLR Q9R0Q1 1 1892.949 2.12 protein 4 N-acetylglucosaminyl- MRSPEQAGLPGAGSR Q5SX19 phosphatidylinositol de- M1(Oxidation) 1 1529.740 2.37 N-acetylase MSEEILALVDEFQQAWPLEGFGGTLE Tetratricopeptide repeat A2AGG1 K28(HeavyDimethyl) 1 3417.677 2.89 MKGR protein 17 Isoform A of Cytosolic N-Term(Dimethyl); MSGPTTDTPAAIQICR Q91V12-2 acyl coenzyme A 1 1746.843 3.53 C15(Carbamidomethyl) thioester hydrolase

Isoform A of Cytosolic N-Term(Dimethyl:2H(6)13C(2)); MSGPTTDTPAAIQICR Q91V12-2 acyl coenzyme A 1 1754.892 3.12 C15(Carbamidomethyl) thioester hydrolase MSIFILTEAQKISHDATFMSIMVWTSVS N-Term(Dimethyl); K11(Dimethyl); Q4KL48 EG667283 protein 1 4710.420 3.18 MVLLLLTPNQDAR M22(Oxidation) M4(Oxidation); K5(HeavyDimethyl); MSLMKNERAIIMSMWEK P06467 Hemoglobin subunit zeta 1 2202.169 2.31 M12(Oxidation); K17(HeavyDimethyl) Homogentisate 1,2- N-Term(Dimethyl:2H(6)13C(2)); MSLQPNEICVIQR O09173 1 1623.876 2.45 dioxygenase C9(Carbamidomethyl) MSLSGASERSVPATK S4R2U2 Copine-9 N-Term(Dimethyl); K15(Dimethyl) 1 1576.817 2.26 N-Term(Dimethyl:2H(6)13C(2)); Tetratricopeptide repeat MSQACHEVDDSSVVGLK E9PV21 C5(Carbamidomethyl); 1 1933.989 3.00 protein 39C K17(HeavyDimethyl) Bifunctional purine N-Term(Dimethyl); MSSFGDFVALSDICDVPTAK Q9CWJ9 biosynthesis protein 1 2216.041 4.04 C14(Carbamidomethyl); K20(Dimethyl) PURH Bifunctional purine N-Term(Dimethyl:2H(6)13C(2)); MSSFGDFVALSDICDVPTAK Q9CWJ9 biosynthesis protein C14(Carbamidomethyl); 2 2232.134 3.55 PURH K20(HeavyDimethyl) MSTNTDLSLSSYDEGQGSKFIR J3QPX3 MCG1125 K19(Dimethyl) 1 2464.173 2.82 C8(Carbamidomethyl); M16(Oxidation); MTAAENVCYTLINVPMDSEPPSEISLK Q9JIF7 Coatomer subunit beta 1 3061.481 2.83 K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K18(HeavyDimethyl); MTDSFTEQADQVTADVGKLLGDQKV Dihydropteridine D3YWR7 K24(HeavyDimethyl); 2 4381.393 5.48 DAILCVAGGWAGGNAK reductase C30(Carbamidomethyl); K41(HeavyDimethyl) Medium-chain-specific acyl-CoA N-Term(Dimethyl); MTEQPMMCAYCVTEPSAGSDVAAIK D3Z2A5 dehydrogenase, C8(Carbamidomethyl); 1 2803.238 4.17 mitochondrial C11(Carbamidomethyl); K25(Dimethyl) (Fragment) Medium-chain-specific N-Term(Dimethyl:2H(6)13C(2)); acyl-CoA C8(Carbamidomethyl); MTEQPMMCAYCVTEPSAGSDVAAIK D3Z2A5 dehydrogenase, 3 2819.334 5.08 C11(Carbamidomethyl); mitochondrial K25(HeavyDimethyl) (Fragment) Medium-chain specific N-Term(Dimethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA C8(Carbamidomethyl); P45952 2 3060.412 5.18 K dehydrogenase, C11(Carbamidomethyl); K25(Dimethyl); mitochondrial K27(Dimethyl) Medium-chain specific N-Term(Dimethyl); M7(Oxidation); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA C8(Carbamidomethyl); P45952 6 3076.413 4.19 K dehydrogenase, C11(Carbamidomethyl); K25(Dimethyl); mitochondrial K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Medium-chain specific C8(Carbamidomethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA P45952 C11(Carbamidomethyl); 2 3084.554 4.47 K dehydrogenase, K25(HeavyDimethyl); mitochondrial K27(HeavyDimethyl) Medium-chain-specific N-Term(Dimethyl:2H(6)13C(2)); acyl-CoA M6(Oxidation); C8(Carbamidomethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT D3Z2A5 dehydrogenase, C11(Carbamidomethyl); 2 3100.545 3.67 K mitochondrial K25(HeavyDimethyl); (Fragment) K27(HeavyDimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Medium-chain specific M7(Oxidation); C8(Carbamidomethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA P45952 C11(Carbamidomethyl); 1 3100.552 2.77 K dehydrogenase, K25(HeavyDimethyl); mitochondrial K27(HeavyDimethyl) Medium-chain specific N-Term(Dimethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA C8(Carbamidomethyl); P45952 4 3416.612 4.33 KAEK dehydrogenase, C11(Carbamidomethyl); K25(Dimethyl); mitochondrial K27(Dimethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Medium-chain specific C8(Carbamidomethyl); MTEQPMMCAYCVTEPSAGSDVAAIKT acyl-CoA C11(Carbamidomethyl); P45952 1 3448.809 3.54 KAEK dehydrogenase, K25(HeavyDimethyl); mitochondrial K27(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); DCC-interacting protein C10(Carbamidomethyl); MTESHLLVTCDCLKLIDPQTQVTR Q8K3H0 1 2930.595 2.25 13-alpha C12(Carbamidomethyl); K14(HeavyDimethyl)

M1(Oxidation); C6(Carbamidomethyl); MTLWTCAAVICMAWTLSVAMAFPPV Probable G-protein Q6PI62 C11(Carbamidomethyl); 1 3705.852 2.77 FDVGTYK coupled receptor 173 M12(Oxidation); K32(HeavyDimethyl)

Transitional N-Term(Dimethyl); MTNGFSGADLTEICQR Q01853 endoplasmic reticulum 11 1827.832 4.75 C14(Carbamidomethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); MTNGFSGADLTEICQR Q01853 endoplasmic reticulum 5 1835.880 4.78 C14(Carbamidomethyl) ATPase MTPPKTNVAHHSTLEGDVTLR G3UXK3 Protein 2410137M14Rik K5(HeavyDimethyl) 1 2340.271 2.57

N-Term(Dimethyl); MTPTDDSDPWWAAFSGACK Q99JW2 Aminoacylase-1 1 2198.938 2.52 C18(Carbamidomethyl); K19(Dimethyl)

Ankyrin repeat domain- MTSEVSVSHEKEK Q811D2 K11(Dimethyl); K13(Dimethyl) 3 1546.800 2.99 containing protein 26 MTSLPMMIFLVILLLPSMPTEGRVLTQ Exocrine gland-secreting N-Term(Dimethyl:2H(6)13C(2)); A8R0U0 1 4436.381 3.26 TQEQSTISADQK peptide 6 M6(Oxidation); K39(HeavyDimethyl) MCG13663, isoform M1(Oxidation); K11(HeavyDimethyl); MTVVQAYINEKHYK G5E829 2 1812.031 2.32 CRA_a K14(HeavyDimethyl) Methylcrotonoyl-CoA N-Term(Dimethyl); MVAAVACAKVPK Q3ULD5 carboxylase beta chain, C7(Carbamidomethyl); K9(Dimethyl); 2 1328.775 2.47 mitochondrial K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Methylcrotonoyl-CoA C7(Carbamidomethyl); MVAAVACAKVPK Q3ULD5 carboxylase beta chain, 2 1352.911 2.38 K9(HeavyDimethyl); mitochondrial K12(HeavyDimethyl) Alcohol dehydrogenase N-Term(Dimethyl); MVATGVCR P00329 1 921.464 2.17 1 C7(Carbamidomethyl) Alcohol dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); MVATGVCR P00329 1 929.504 2.21 1 C7(Carbamidomethyl) MVDDGSGEVQVWR Q62468 Villin-1 1 1477.696 2.04 Transmembrane and MVELDADLDHIVPSVLPPFWAKTSSQT K22(HeavyDimethyl); D6RH66 TPR repeat-containing 1 4551.294 3.00 RPLGTCGTMTSGAVN C33(Carbamidomethyl); M36(Oxidation) protein 4 Isoform 2 of ATPase MVGVLSMAAAAAPLPVK Q4QY64-2 family AAA domain- M7(Oxidation); K17(Dimethyl) 1 1669.935 2.63 containing protein 5 N-Term(Dimethyl:2H(6)13C(2)); MVIVCLITMFFAMVLLMGTLYIHMFLF P33033 Melanocortin receptor 3 C5(Carbamidomethyl); M13(Oxidation); 1 3549.916 3.02 AR M17(Oxidation) Staphylococcal nuclease N-Term(Dimethyl); MVLSGCAIIVR Q3TJ56 domain-containing 1 1246.698 2.16 C6(Carbamidomethyl) protein 1 Staphylococcal nuclease N-Term(Dimethyl:2H(6)13C(2)); MVLSGCAIIVR Q3TJ56 domain-containing 2 1254.746 2.44 C6(Carbamidomethyl) protein 1 M1(Oxidation); M3(Oxidation); MVMIQDGPLPTGADKPLR A2AJ72 MCG130458 1 1999.013 2.50 K15(Dimethyl) C10(Carbamidomethyl); MVMPWSSPLCTMPSKSAFFSQPRVEA Q8CDE8 4933411G11Rik protein M12(Oxidation); K15(HeavyDimethyl); 1 4123.155 2.93 TPQPPSSIQK K36(HeavyDimethyl) M1(Oxidation); M3(Oxidation); MVMPWSSPLCTMPSKSAFFSQPRVEA C10(Carbamidomethyl); Q8CDE8 4933411G11Rik protein 1 4138.991 3.04 TPQPPSSIQK M12(Oxidation); K15(Dimethyl); K36(Dimethyl) N-Term(Dimethyl); MVNLQSGGFSCTIRYRK Q9WTS5 Teneurin-2 1 2073.090 2.32 C11(Carbamidomethyl); K17(Dimethyl) MVNRLNWSSIEQSQFSELMESLR Q9ES18 Forkhead box protein J2 M19(Oxidation) 2 2800.314 3.01 Bifunctional ATP- dependent MVNSVEGCADDALAGLVASNPDLQLL N-Term(Dimethyl); Q8VC30 dihydroxyacetone 5 3178.573 5.70 QGHR C8(Carbamidomethyl) kinase/FAD-AMP lyase (cyclizing) Bifunctional ATP- dependent MVNSVEGCADDALAGLVASNPDLQLL N-Term(Dimethyl:2H(6)13C(2)); Q8VC30 dihydroxyacetone 3 3186.616 5.22 QGHR C8(Carbamidomethyl) kinase/FAD-AMP lyase (cyclizing) N-Term(Dimethyl:2H(6)13C(2)); MVQAALTPDSCYPD P01592 Immunoglobulin J chain 1 1603.750 2.40 C11(Carbamidomethyl) Protein transport protein N-Term(Dimethyl); MVQVHELGCEGISK E9Q1S3 1 1642.822 2.72 Sec23A C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein transport protein MVQVHELGCEGISK E9Q1S3 C9(Carbamidomethyl); 3 1658.911 3.48 Sec23A K14(HeavyDimethyl) Isoform 2 of Platelet- activating factor N-Term(Dimethyl); MVRPNQDGTLIASCSNDQTVR P63005-2 2 2390.145 3.24 acetylhydrolase IB C14(Carbamidomethyl) subunit alpha Isoform 2 of Platelet- activating factor N-Term(Dimethyl:2H(6)13C(2)); MVRPNQDGTLIASCSNDQTVR P63005-2 1 2398.197 2.79 acetylhydrolase IB C14(Carbamidomethyl) subunit alpha MVSASVPALSSCHPWAGVLAHLERLE Centromere protein O B8JK51 C12(Carbamidomethyl) 1 3701.856 2.76 AQTNISNR (Fragment) N-Term(Dimethyl:2H(6)13C(2)); MVSDFMLGNKYISFIGCGFQIFLFLTFG Q8VGJ5 Olfactory receptor M6(Oxidation); K10(HeavyDimethyl); 1 4848.452 3.53 GAETLLLASMAYDR C17(Carbamidomethyl); M38(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Macrophage mannose MVSQSHAVVPEGADKGCR Q61830 K15(HeavyDimethyl); 1 2000.058 2.75 receptor 1 C17(Carbamidomethyl) MVSQTGPVHAPVFAVAVEVNGLTFEG N-Term(Dimethyl); K31(Dimethyl); Q6PB89 Adarb2 protein 1 3352.782 3.01 TGPTKK K32(Dimethyl) MVVPVAALFTPLKERPDLPPIQYEPVL Protein transport protein N-Term(Dimethyl); K13(Dimethyl); E9Q1S3 1 3491.955 3.21 CSR Sec23A C28(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MVVPVAALFTPLKERPDLPPIQYEPVL Protein transport protein E9Q1S3 K13(HeavyDimethyl); 3 3508.028 3.76 CSR Sec23A C28(Carbamidomethyl) MVVSAIVDTLK Q6P4T1 Protein Snx19 K11(Dimethyl) 1 1203.689 2.27 N-Term(Dimethyl:2H(6)13C(2)); MWQKMLEDANSATLERDER A2ANX3 Protein Atp8b4 1 2395.210 2.57 K4(HeavyDimethyl) MYDSMLALPQDLQAARALMVISIIVGA N-Term(Dimethyl); M5(Oxidation); O35054 Claudin-4 1 4017.203 3.99 LGMLLSVVGGK K38(Dimethyl) C35(Carbamidomethyl); MYRDPEAASPGAPTRDVLLVSAIITVS Q9R0N7 Synaptotagmin-7 C38(Carbamidomethyl); 1 4812.391 3.11 LSVTIVLCGLCHWCQR C41(Carbamidomethyl) MYTDIQEPMLNAAQEQFGGNPFATVG Q9QZM0 Ubiquilin-2 M1(Oxidation) 2 4106.792 2.75 SSSTSGEGTQPSR Coagulation factor XIII MYVAVWTPYGILR Q8BH61 M1(Oxidation) 1 1584.836 2.10 A chain N-Term(Dimethyl); NAAIANHCFTCALNR Q8VC97 Beta-ureidopropionase C8(Carbamidomethyl); 5 1760.824 3.67 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NAAIANHCFTCALNR Q8VC97 Beta-ureidopropionase C8(Carbamidomethyl); 8 1768.867 3.46 C11(Carbamidomethyl) NADH dehydrogenase [ubiquinone] N-Term(Dimethyl); NACGSDYDFDVFVVR D3Z1U9 4 1791.789 3.44 flavoprotein 1, C3(Carbamidomethyl) mitochondrial

NADH dehydrogenase [ubiquinone] N-Term(Dimethyl:2H(6)13C(2)); NACGSDYDFDVFVVR D3Z1U9 1 1799.841 3.13 flavoprotein 1, C3(Carbamidomethyl) mitochondrial

N-Term(Dimethyl); Xanthine C3(Carbamidomethyl); NACVDQFTTLCATGTPENCK Q00519 1 2343.047 5.14 dehydrogenase/oxidase C11(Carbamidomethyl); C19(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); Xanthine NACVDQFTTLCATGTPENCK Q00519 C11(Carbamidomethyl); 1 2359.123 4.06 dehydrogenase/oxidase C19(Carbamidomethyl); K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NAFACFDEEAIGTIQEDYLR Q6ZWQ9 MCG5400 1 2398.153 2.45 C5(Carbamidomethyl) Methylcytosine N-Term(Dimethyl); K12(Dimethyl); NAGGMTGIEVEKWAPNKK E9Q9Y4 1 2042.086 2.47 dioxygenase TET1 K17(Dimethyl); K18(Dimethyl) N-Term(Dimethyl); Isoform 2 of Proton- C19(Carbamidomethyl); NAGILMGPLSLLVMGLIACHCMHILVR Q8BHK3-2 coupled amino acid C21(Carbamidomethyl); 1 4133.152 3.17 CAQRFCHR transporter 2 C28(Carbamidomethyl); C33(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); K5(Dimethyl); NAGLKCELLAK Q91WT9-2 Cystathionine beta- 6 1300.763 2.73 C6(Carbamidomethyl); K11(Dimethyl) synthase N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of K5(HeavyDimethyl); NAGLKCELLAK Q91WT9-2 Cystathionine beta- 1 1324.895 2.03 C6(Carbamidomethyl); synthase K11(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Tetratricopeptide repeat NAGLPLSTTSNEACK A3KMP2 C14(Carbamidomethyl); 1 1634.893 2.22 protein 38 K15(HeavyDimethyl) T-complex protein 1 N-Term(Dimethyl); NAIDDGCVVPGAGAVEVALAEALIK P80317 7 2508.335 3.89 subunit zeta C7(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 NAIDDGCVVPGAGAVEVALAEALIK P80317 C7(Carbamidomethyl); 1 2524.435 4.12 subunit zeta K25(HeavyDimethyl) Cytochrome b-c1 N-Term(Dimethyl); NALANPLYCPDYR Q9DB77 complex subunit 2, 14 1594.767 3.76 C9(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); NALANPLYCPDYR Q9DB77 complex subunit 2, 10 1602.815 3.75 C9(Carbamidomethyl) mitochondrial N-Term(Dimethyl); K18(Dimethyl); NALPTPSDDPTALMTDPKYIIWSPVCR P11352 Glutathione peroxidase 1 2 3114.575 2.79 C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NALPTPSDDPTALMTDPKYIIWSPVCR P11352 Glutathione peroxidase 1 K18(HeavyDimethyl); 2 3130.643 3.96 C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NALPTPSDDPTALMTDPKYIIWSPVCR K18(HeavyDimethyl); P11352 Glutathione peroxidase 1 2 4284.267 3.61 NDIAWNFEK C26(Carbamidomethyl); K36(HeavyDimethyl) Cytochrome b-c1 N-Term(Dimethyl); NALVSHLDGTTPVCEDIGR Q9CZ13 complex subunit 1, 19 2082.031 5.00 C14(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); NALVSHLDGTTPVCEDIGR Q9CZ13 complex subunit 1, 22 2090.070 5.43 C14(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl); NALVSHLDGTTPVCEDIGRSLLTYGR Q9CZ13 complex subunit 1, 1 2872.465 3.09 C14(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); NALVSHLDGTTPVCEDIGRSLLTYGR Q9CZ13 complex subunit 1, 1 2880.522 2.65 C14(Carbamidomethyl) mitochondrial Hydroxymethylglutaryl- N-Term(Dimethyl); NANCSIEESFQR P38060 CoA lyase, 1 1482.665 2.27 C4(Carbamidomethyl) mitochondrial Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); NANCSIEESFQR P38060 CoA lyase, 1 1490.703 2.04 C4(Carbamidomethyl) mitochondrial NATSAMLVGRKDLVQVWSLATVATD Isoform 2 of WD repeat- M6(Oxidation); K11(Dimethyl); Q8C0M0-2 1 3386.783 2.97 LCLGPK containing protein 59 C27(Carbamidomethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropteridine NCDMMWK D3YWR7 C2(Carbamidomethyl); 1 1056.525 1.89 reductase K7(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropteridine C2(Carbamidomethyl); NCDMMWKQSMWTSTISSHLATK D3YWR7 1 2751.405 3.66 reductase K7(HeavyDimethyl); K22(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); NCIVLIDSTPYR P62242 1 1486.808 2.05 S8 C2(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); NCIVLIDSTPYRQWYESHYALPLGR P62242 3 3079.554 3.04 S8 C2(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); NCIVLIDSTPYRQWYESHYALPLGR P62242 1 3087.611 3.00 S8 C2(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); NCLTNFHGMDLTR D3Z6C3 1 1622.735 2.23 S3a C2(Carbamidomethyl); M9(Oxidation) Homogentisate 1,2- N-Term(Dimethyl); NCMSEFMGLIK O09173 1 1385.668 2.31 dioxygenase C2(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- NCMSEFMGLIK O09173 C2(Carbamidomethyl); 3 1401.754 2.46 dioxygenase K11(HeavyDimethyl) N-Term(Dimethyl); Homogentisate 1,2- NCMSEFMGLIKGHYEAK O09173 C2(Carbamidomethyl); K11(Dimethyl); 1 2099.025 2.79 dioxygenase K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- C2(Carbamidomethyl); NCMSEFMGLIKGHYEAK O09173 1 2123.160 2.79 dioxygenase K11(HeavyDimethyl); K17(HeavyDimethyl) Spliceosome RNA N-Term(Dimethyl); NCPHIVVGTPGR G3UXI6 helicase Ddx39b 1 1334.700 2.09 C2(Carbamidomethyl) (Fragment) Ral GTPase-activating NCSPRFFSLGLPGFSMLVGDFITAAAR N-Term(Dimethyl:2H(6)13C(2)); F7CGP0 protein subunit alpha-2 1 4138.162 2.84 VLSTDMLAAPR C2(Carbamidomethyl); M33(Oxidation) (Fragment) Glyoxylate N-Term(Dimethyl); NCVILPHIGSATYK Q91Z53 reductase/hydroxypyruv 7 1628.876 2.96 C2(Carbamidomethyl); K14(Dimethyl) ate reductase Glyoxylate N-Term(Dimethyl:2H(6)13C(2)); NCVILPHIGSATYK Q91Z53 reductase/hydroxypyruv C2(Carbamidomethyl); 5 1644.968 3.14 ate reductase K14(HeavyDimethyl) Cytochrome c oxidase N-Term(Dimethyl); NCWQNYLDFHR P56391 1 1580.702 2.37 subunit 6B1 C2(Carbamidomethyl) N-Term(Dimethyl); NDLGHPFCENLR F8VPN4 Protein Agl 2 1499.702 2.54 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NDLGHPFCENLR F8VPN4 Protein Agl 2 1507.745 2.36 C8(Carbamidomethyl) K29(HeavyDimethyl); NDLISHYALSFNLLVPSETNFLHFTWH Tyrosine-protein kinase H9H9R6 K31(HeavyDimethyl); 1 4257.360 2.81 AKSKVEYK RYK K35(HeavyDimethyl) NDQLANQVVVQLLPFMVITSNDIESPD HEAT repeat containing N-Term(Dimethyl:2H(6)13C(2)); G3X9B1 1 3346.735 3.49 MK 1 M28(Oxidation); K29(HeavyDimethyl) N-Term(Dimethyl); NDSPCGTTIGPILASR Q9Z2W0 Aspartyl aminopeptidase 3 1686.842 4.10 C5(Carbamidomethyl) NEATEMETLVEAEK Q3UR03 Myomegalin (Fragment) K14(HeavyDimethyl) 1 1629.810 2.09 Fatty acid-binding N-Term(Dimethyl); NEFTLGEECELETMTGEK P12710 1 2172.964 3.25 protein, liver C9(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty acid-binding NEFTLGEECELETMTGEK P12710 C9(Carbamidomethyl); 2 2189.070 3.82 protein, liver K18(HeavyDimethyl) N-Term(Dimethyl); Fatty acid-binding NEFTLGEECELETMTGEKVK P12710 C9(Carbamidomethyl); K18(Dimethyl); 2 2428.163 4.14 protein, liver K20(Dimethyl)

N-Term(Dimethyl); C4(Carbamidomethyl); M7(Oxidation); C9(Carbamidomethyl); NEGCLHMTCARCNHGFCWRCLK Q80TT8-2 Isoform 2 of Cullin-9 1 2939.262 2.98 C12(Carbamidomethyl); C17(Carbamidomethyl); C20(Carbamidomethyl); K22(Dimethyl)

Coiled-coil protein NEGQVQGADVLAVNGTREDGLPMDL A2AST1 associated with myosin N-Term(Dimethyl:2H(6)13C(2)) 1 2946.499 2.74 RR II and DISC1 Dihydrolipoyl N-Term(Dimethyl); NETLGGTCLNVGCIPSK O08749 dehydrogenase, C8(Carbamidomethyl); 2 1875.930 3.03 mitochondrial C13(Carbamidomethyl); K17(Dimethyl)

Isoform 3 of A-kinase N-Term(Dimethyl); NFEVNYQELQREYTCLLK Q70FJ1-3 1 2403.193 2.43 anchor protein 9 C15(Carbamidomethyl); K18(Dimethyl) Polypeptide N- NFFYIISPGVTKVDYGDISSRLGLR O08912 acetylgalactosaminyltran K12(HeavyDimethyl) 1 2853.599 2.33 sferase 1 Heterogeneous nuclear N-Term(Dimethyl); NFILDQCNVYNSGQR Q00PI9 ribonucleoprotein U-like 8 1855.862 3.92 C7(Carbamidomethyl) protein 2

Heterogeneous nuclear N-Term(Dimethyl:2H(6)13C(2)); NFILDQCNVYNSGQR Q00PI9 ribonucleoprotein U-like 5 1863.910 3.55 C7(Carbamidomethyl) protein 2 N-Term(Dimethyl); NFIMEGGAMVLADGGVVCIDEFDKMR DNA replication P49718 C18(Carbamidomethyl); K24(Dimethyl); 1 3461.542 3.17 EDDR licensing factor MCM5 M25(Oxidation) NFPSSCVLGPEGTPASWTLMDQTGEM Isoform 2 of Glycine N- N-Term(Dimethyl); Q91XE0-2 1 2996.343 3.54 R acyltransferase C6(Carbamidomethyl) NFPSSCVLGPEGTPASWTLMDQTGEM Isoform 2 of Glycine N- N-Term(Dimethyl:2H(6)13C(2)); Q91XE0-2 4 3004.420 4.60 R acyltransferase C6(Carbamidomethyl) NFTDVHPDYGAR P24270 Catalase 1 1391.631 1.92 Protein BC067074 NFTFHHGIYIGGR F6RXI4 N-Term(Dimethyl) 1 1546.800 2.42 (Fragment)

NFYLMTNGFHMTWSVKLDEHIIPLGS Tubulin polyglutamylase M11(Oxidation); K16(HeavyDimethyl); E9PUD7 1 3997.092 2.79 MVINGISK complex subunit 2 M27(Oxidation); K34(HeavyDimethyl)

F-box-like/WD repeat- N-Term(Dimethyl:2H(6)13C(2)); NGENTANGEENGAHTIANNHTDMME Q8BHJ5 containing protein M23(Oxidation); M24(Oxidation); 1 4467.073 4.12 VDGDVEIPSNKAVVLR TBL1XR1 K36(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NGIKHVHAFIHTPTGTHFCEVEQMR D3Z4U1 Uricase K4(HeavyDimethyl); 1 3018.572 3.62 C19(Carbamidomethyl) 3-ketoacyl-CoA thiolase N-Term(Dimethyl); NGSYDIGMACGVESMTLSQR Q8VCH0 3 2203.980 3.79 B, peroxisomal C10(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl); NGSYDIGMACGVESMTLSQR Q8VCH0 3 2219.967 4.45 B, peroxisomal C10(Carbamidomethyl); M15(Oxidation)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); NGSYDIGMACGVESMTLSQR Q8VCH0 3 2212.032 4.48 B, peroxisomal C10(Carbamidomethyl)

3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); NGSYDIGMACGVESMTLSQR Q8VCH0 3 2228.011 3.99 B, peroxisomal C10(Carbamidomethyl); M15(Oxidation)

NGSYDIGMACGVESMTLSQRGNHGNI 3-ketoacyl-CoA thiolase N-Term(Dimethyl:2H(6)13C(2)); Q8VCH0 1 3134.458 2.74 SSR B, peroxisomal C10(Carbamidomethyl) N-Term(Dimethyl); NHPEPSTEQIMETLGGNLCR G3X982 Aldehyde oxidase 3 1 2311.080 2.41 C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NHPEPSTEQIMETLGGNLCR G3X982 Aldehyde oxidase 3 1 2319.131 2.86 C19(Carbamidomethyl) NHSPFNLSDFNLLSIQEMLVYKDVQD G5E8F4 MCG140999 N-Term(Dimethyl); K22(Dimethyl) 1 3756.862 3.10 MLAYR Isoform 2 of CWF19- NHVVLQESAQHATR Q8CI33-2 N-Term(Dimethyl:2H(6)13C(2)) 1 1625.881 2.06 like protein 1 Sodium/potassium- N-Term(Dimethyl); NIAFFSTNCVEGTAR Q8VDN2 transporting ATPase 10 1714.812 3.47 C9(Carbamidomethyl) subunit alpha-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); NIAFFSTNCVEGTAR Q8VDN2 transporting ATPase 9 1722.868 3.54 C9(Carbamidomethyl) subunit alpha-1 N-Term(Dimethyl); NIEDRVQEEAQCLVEELR Q3UT49 Cytochrome P450 2C29 2 2258.111 3.78 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NIEDRVQEEAQCLVEELR Q3UT49 Cytochrome P450 2C29 8 2266.159 3.77 C12(Carbamidomethyl) N-Term(Dimethyl); NIEDRVQEEAQCLVEELRK Q3UT49 Cytochrome P450 2C29 1 2414.235 3.81 C12(Carbamidomethyl); K19(Dimethyl)

Microtubule-associated N-Term(Dimethyl); NIELICQENEGENDPVLQR Q61166 protein RP/EB family 2 2298.097 4.21 C6(Carbamidomethyl) member 1

Microtubule-associated N-Term(Dimethyl:2H(6)13C(2)); NIELICQENEGENDPVLQR Q61166 protein RP/EB family 1 2306.149 4.96 C6(Carbamidomethyl) member 1 N-Term(Dimethyl); NIETFAMNICEHFLSSFNHVTR D3Z4U1 Uricase 15 2695.293 4.86 C10(Carbamidomethyl) N-Term(Dimethyl); M7(Oxidation); NIETFAMNICEHFLSSFNHVTR D3Z4U1 Uricase 10 2711.260 4.57 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NIETFAMNICEHFLSSFNHVTR D3Z4U1 Uricase 17 2703.311 4.70 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NIETFAMNICEHFLSSFNHVTR D3Z4U1 Uricase 13 2719.325 4.15 M7(Oxidation); C10(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); K3(Dimethyl); NIKTIAECLADELINAAK D3YYM6 2 2071.164 2.88 S5 (Fragment) C8(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein K3(HeavyDimethyl); NIKTIAECLADELINAAK D3YYM6 1 2095.288 2.76 S5 (Fragment) C8(Carbamidomethyl); K18(HeavyDimethyl) Isocitrate dehydrogenase N-Term(Dimethyl); NILGGTVFREAIICK O88844 2 1746.989 3.47 [NADP] cytoplasmic C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase NILGGTVFREAIICK O88844 C14(Carbamidomethyl); 4 1763.094 2.72 [NADP] cytoplasmic K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Protein NIMMVVVEAMINKFEEDETRSEDR Q3URV1-2 M3(Oxidation); M4(Oxidation); 1 2989.525 2.91 broad-minded K13(HeavyDimethyl) Protein Jumonji N-Term(Dimethyl); NIMNMCFSKEPAPAEIEQEYWR G3UZT8 1 2799.314 2.85 (Fragment) C6(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl); Beta-lactamase-like NINNDTTYCIKK Q99KR3 C9(Carbamidomethyl); K11(Dimethyl); 1 1567.813 2.23 protein 2 K12(Dimethyl) T-complex protein 1 N-Term(Dimethyl); NIQACKELAQTTR H3BL49 2 1588.840 3.08 subunit theta C5(Carbamidomethyl); K6(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 NIQACKELAQTTR H3BL49 C5(Carbamidomethyl); 1 1604.929 2.78 subunit theta K6(HeavyDimethyl) Isoform 5 of Ankyrin N-Term(Dimethyl:2H(6)13C(2)); repeat and sterile alpha C4(Carbamidomethyl); NISCAAQDPEDLSTFAYITKDLK Q8BIZ1-5 1 2708.461 2.65 motif domain-containing K20(HeavyDimethyl); protein 1B K23(HeavyDimethyl) Vacuolar protein-sorting- N-Term(Dimethyl); K11(Dimethyl); NISEAFEDLSKLMIK Q91XD6 1 1838.002 2.53 associated protein 36 M13(Oxidation); K15(Dimethyl) NITIASQEGSLEPGMIPQSGVFGFPPGN E3 ubiquitin-protein D3Z3K2 K31(HeavyDimethyl) 1 3209.650 2.82 NSK ligase CCNB1IP1 NKDGIVTLDEFLESCQEDDNIMRSLQL Isoform 3 of Kv channel- N-Term(Dimethyl); K2(Dimethyl); Q9JJ57-3 1 3873.856 3.03 FQNVM interacting protein 1 C15(Carbamidomethyl); M32(Oxidation) Phosphoenolpyruvate N-Term(Dimethyl:2H(6)13C(2)); NKEWRPQDAEPCAHPNSR Q9Z2V4 carboxykinase, cytosolic K2(HeavyDimethyl); 1 2264.159 2.43 [GTP] C12(Carbamidomethyl) Glutathione S- N-Term(Dimethyl); K2(Dimethyl); NKLIENTDAACK Q9DCM2 1 1460.772 2.74 transferase kappa 1 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- K2(HeavyDimethyl); NKLIENTDAACK Q9DCM2 1 1484.904 2.09 transferase kappa 1 C11(Carbamidomethyl); K12(HeavyDimethyl) Xanthine N-Term(Dimethyl); K2(Dimethyl); NKPEPTVEEIENAFQGNLCR Q00519 1 2401.177 2.87 dehydrogenase/oxidase C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Xanthine NKPEPTVEEIENAFQGNLCR Q00519 K2(HeavyDimethyl); 2 2417.270 2.95 dehydrogenase/oxidase C19(Carbamidomethyl) NADP-dependent malic N-Term(Dimethyl); K2(Dimethyl); NKYCTFNDDIQGTASVAVAGLLAALR P06801 1 2824.460 2.78 enzyme C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NADP-dependent malic NKYCTFNDDIQGTASVAVAGLLAALR P06801 K2(HeavyDimethyl); 1 2840.551 3.22 enzyme C4(Carbamidomethyl) Eukaryotic translation N-Term(Dimethyl); NLAMEATYINHNFSQQCLR O70194 initiation factor 3 1 2338.102 4.73 C17(Carbamidomethyl) subunit D Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); NLAMEATYINHNFSQQCLR O70194 initiation factor 3 1 2346.162 2.92 C17(Carbamidomethyl) subunit D Acyl-coenzyme A N-Term(Dimethyl); NLCLLYSLYGISQK A2A848 9 1727.942 3.74 oxidase (Fragment) C3(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acyl-coenzyme A NLCLLYSLYGISQK A2A848 C3(Carbamidomethyl); 8 1744.028 4.47 oxidase (Fragment) K14(HeavyDimethyl) Aspartate N-Term(Dimethyl); K4(Dimethyl); NLDKEYLPIGGLAEFCK P05202 aminotransferase, 13 2051.087 5.32 C16(Carbamidomethyl); K17(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Aspartate K4(HeavyDimethyl); NLDKEYLPIGGLAEFCK P05202 aminotransferase, 12 2075.218 5.30 C16(Carbamidomethyl); mitochondrial K17(HeavyDimethyl) Aspartate N-Term(Dimethyl); K4(Dimethyl); NLDKEYLPIGGLAEFCKASAELALGEN P05202 aminotransferase, C16(Carbamidomethyl); K17(Dimethyl); 1 3617.917 3.26 NEVLK mitochondrial K32(Dimethyl) Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); NLEAVETLGSTSTICSDK Q8VDN2 transporting ATPase C15(Carbamidomethyl); 1 1997.079 3.56 subunit alpha-1 K18(HeavyDimethyl) Sodium/potassium- N-Term(Dimethyl); NLEAVETLGSTSTICSDKTGTLTQNR Q8VDN2 transporting ATPase 4 2852.438 4.96 C15(Carbamidomethyl); K18(Dimethyl) subunit alpha-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); NLEAVETLGSTSTICSDKTGTLTQNR Q8VDN2 transporting ATPase C15(Carbamidomethyl); 4 2868.518 3.80 subunit alpha-1 K18(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); NLGEILKAAGCDFNNVVK P52760 Ribonuclease UK114 1 2046.115 2.65 C11(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl); NLGVFPFPVAPYPYQLCAVMR P24456 Cytochrome P450 2D10 6 2467.278 3.56 C17(Carbamidomethyl) N-Term(Dimethyl); NLGVFPFPVAPYPYQLCAVMR P24456 Cytochrome P450 2D10 2 2483.270 2.83 C17(Carbamidomethyl); M20(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); NLGVFPFPVAPYPYQLCAVMR P24456 Cytochrome P450 2D10 5 2475.315 3.82 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NLGVFPFPVAPYPYQLCAVMR P24456 Cytochrome P450 2D10 2 2491.329 3.21 C17(Carbamidomethyl); M20(Oxidation) N-Term(Dimethyl); NLGVFPFPVAPYPYQLCAVMREQGH P24456 Cytochrome P450 2D10 3 2918.443 3.20 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NLGVFPFPVAPYPYQLCAVMREQGH P24456 Cytochrome P450 2D10 3 2926.499 3.10 C17(Carbamidomethyl) NLKNFIESLSRNQASDHPAIVLYAMIG K3(Dimethyl); M25(Oxidation); O35298 Acyloxyacyl hydrolase 1 3890.989 3.02 NDVCNSK C31(Carbamidomethyl); K34(Dimethyl) Acyl-CoA N-Term(Dimethyl); NLPDSDSEECLVHGDFK D3YTQ5 dehydrogenase family 1 2017.918 2.41 C10(Carbamidomethyl); K17(Dimethyl) member 11 Acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); NLPDSDSEECLVHGDFK D3YTQ5 dehydrogenase family C10(Carbamidomethyl); 1 2034.002 2.84 member 11 K17(HeavyDimethyl) N-Term(Dimethyl); K10(Dimethyl); NLPDTFNEAKLLTFSMLVFCSVWITFL E9Q067 Protein Vmn2r79 M16(Oxidation); 2 4119.127 3.18 PVYHSTK C20(Carbamidomethyl); K34(Dimethyl) GRIP and coiled-coil NLQADNSMYLASLGQK E0CYI9 domain-containing K16(Dimethyl) 1 1780.911 2.24 protein 2 Probable proline N-Term(Dimethyl); NLQLSCLSTEQNQHLQASLSR Q8VCZ9 1 2455.232 5.62 dehydrogenase 2 C6(Carbamidomethyl) Probable proline N-Term(Dimethyl:2H(6)13C(2)); NLQLSCLSTEQNQHLQASLSR Q8VCZ9 1 2463.277 4.19 dehydrogenase 2 C6(Carbamidomethyl) Apolipoprotein B-100 N-Term(Dimethyl); NLQQCDGFQPISTSVSPLALIK E9Q4G4 1 2472.321 2.53 (Fragment) C5(Carbamidomethyl); K22(Dimethyl) ES1 protein homolog, N-Term(Dimethyl); K10(Dimethyl); NLSTFAVDGKDCK Q9D172 6 1538.785 2.60 mitochondrial C12(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl); K4(Dimethyl); NLVKTNCDLYEK P07724 Serum albumin 1 1580.830 2.30 C7(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); NLVKTNCDLYEK P07724 Serum albumin 1 1604.966 2.12 C7(Carbamidomethyl); K12(HeavyDimethyl) N-Term(Dimethyl); K4(Dimethyl); NLVKTNCDLYEKLGEYGFQNAILVR P07724 Serum albumin 8 3041.619 4.25 C7(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); NLVKTNCDLYEKLGEYGFQNAILVR P07724 Serum albumin 4 3065.739 3.74 C7(Carbamidomethyl); K12(HeavyDimethyl) Aspartate N-Term(Dimethyl:2H(6)13C(2)); NMGLYGERVGAFTVVCK P05202 aminotransferase, C16(Carbamidomethyl); 1 1973.096 2.34 mitochondrial K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aspartate C16(Carbamidomethyl); NMGLYGERVGAFTVVCKDAEEAK P05202 aminotransferase, 1 2652.455 2.75 K17(HeavyDimethyl); mitochondrial K23(HeavyDimethyl) NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- N-Term(Dimethyl); P10126 12 2965.520 5.51 SK alpha 1 C11(Carbamidomethyl); K29(Dimethyl)

NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- N-Term(Dimethyl); M2(Oxidation); P10126 1 2981.467 2.71 SK alpha 1 C11(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- P10126 C11(Carbamidomethyl); 12 2981.584 6.32 SK alpha 1 K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- P10126 M2(Oxidation); C11(Carbamidomethyl); 1 2997.574 3.17 SK alpha 1 K29(HeavyDimethyl)

NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- N-Term(Dimethyl); P10126 1 3521.769 2.92 SKNGQTR alpha 1 C11(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NMITGTSQADCAVLIVAAGVGEFEAGI Elongation factor 1- P10126 C11(Carbamidomethyl); 2 3537.866 4.06 SKNGQTR alpha 1 K29(HeavyDimethyl) K5(HeavyDimethyl); M9(Oxidation); Phosphoglycerate kinase NMLDKVNFMIIGGGMAYTFLKELK P09041 M15(Oxidation); K21(HeavyDimethyl); 1 2873.655 2.75 2 K24(HeavyDimethyl) N-Term(Dimethyl); C6(Carbamidomethyl); NMLIDCENQCVIISGESGAGKTVAAKY Unconventional myosin- G3V011 C10(Carbamidomethyl); K21(Dimethyl); 1 3848.970 3.27 IMGYISK If K26(Dimethyl); M29(Oxidation); K34(Dimethyl) N-Term(Dimethyl); NMMAACDPR P99024 Tubulin beta-5 chain 2 1093.456 2.29 C6(Carbamidomethyl) M18(Oxidation); NMNWDQPHTPQYLLATLMPSPELGEL D3Z2X2 Protein Dnhd1 C32(Carbamidomethyl); 1 3893.832 3.05 DARTDCK K33(HeavyDimethyl) Sarcosine N-Term(Dimethyl); NMRRDPLHEELLGQGCVFQER Q99LB7 dehydrogenase, 7 2612.279 3.72 C16(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); NMRRDPLHEELLGQGCVFQER Q99LB7 dehydrogenase, 11 2620.317 4.25 C16(Carbamidomethyl) mitochondrial NMSQLMEMGEASDDLASQMIYQLVA M2(Oxidation); M6(Oxidation); G3UWL5 Protein Adamtsl3 1 3300.551 3.00 ELAK M8(Oxidation); K29(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); NMSVHLSPCFR P62281 1 1375.655 2.40 S11 C9(Carbamidomethyl) N-Term(Dimethyl); K12(Dimethyl); NMSVIAHVDHGKSTLTDSLVCK P58252 Elongation factor 2 6 2496.280 3.56 C21(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K12(HeavyDimethyl); NMSVIAHVDHGKSTLTDSLVCK P58252 Elongation factor 2 2 2520.419 3.07 C21(Carbamidomethyl); K22(HeavyDimethyl) NNDTSFVSYTMMVIVVNFIVPLTVMF Visual pigment-like O35214 M12(Oxidation); C28(Carbamidomethyl) 2 4125.905 3.03 YCYYHVSR receptor peropsin Peroxisomal N-Term(Dimethyl); NNIHCNTIAPNAGSR P51660 multifunctional enzyme 4 1666.804 3.32 C5(Carbamidomethyl) type 2 Peroxisomal N-Term(Dimethyl:2H(6)13C(2)); NNIHCNTIAPNAGSR P51660 multifunctional enzyme 3 1674.849 3.76 C5(Carbamidomethyl) type 2 NNPAIVVIGNNGQINYDHQNDGATQA Protein ERGIC-53 N-Term(Dimethyl); D3Z5B9 4 3480.670 4.85 LASCQR (Fragment) C30(Carbamidomethyl) NNPAIVVIGNNGQINYDHQNDGATQA Protein ERGIC-53 N-Term(Dimethyl:2H(6)13C(2)); D3Z5B9 7 3488.722 4.68 LASCQR (Fragment) C30(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NPEDVQSPNGSVYTWREAFNETNQAI ATP-binding cassette M33(Oxidation); P41233 1 4775.291 2.84 QTISRFMECVNLNK sub-family A member 1 C35(Carbamidomethyl); K40(HeavyDimethyl) Integrator complex NPGPGR Q8CIM8 2 597.307 0.55 subunit 4 N-Term(Dimethyl:2H(6)13C(2)); SH3 and cysteine-rich M6(Oxidation); M7(Oxidation); NPLAAMMEEEPESARPEEGKSQDGNN Q8BZ71 domain-containing K20(HeavyDimethyl); 1 3577.812 2.84 AEKDK protein 3 K29(HeavyDimethyl); K31(HeavyDimethyl) N-Term(Dimethyl); NPNFDVCTLFMEVMLPR Q9ESD7-3 Isoform 3 of Dysferlin C7(Carbamidomethyl); M11(Oxidation); 1 2142.973 2.37 M14(Oxidation) K7(HeavyDimethyl); NPTSPPKPCGLVPNVKMSLLVFLGLLG C9(Carbamidomethyl); O55196 Enamelin 1 4412.387 2.94 VSAAMPFQMPMPR K16(HeavyDimethyl); M32(Oxidation); M36(Oxidation); M38(Oxidation) Isoform 4 of Mitochondrial peptide N-Term(Dimethyl); K5(Dimethyl); NPTYKEVCSEK Q9D6Y7-4 1 1438.718 2.20 methionine sulfoxide C8(Carbamidomethyl); K11(Dimethyl) reductase NQAFLTGSHISVADLVAITELMHPVSA Glutathione S- N-Term(Dimethyl); Q99L20 4 3222.675 4.87 GCK transferase theta 3 C29(Carbamidomethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NQAFLTGSHISVADLVAITELMHPVSA Glutathione S- Q99L20 C29(Carbamidomethyl); 5 3238.770 5.73 GCK transferase theta 3 K30(HeavyDimethyl) E3 ubiquitin-protein NQALQELISELER Q3U7K7 N-Term(Dimethyl:2H(6)13C(2)) 1 1578.881 2.01 ligase TRIM21 2-hydroxyacyl-CoA N-Term(Dimethyl); NQEAMGAFQEFPQVEACR D3YZ54 3 2139.959 6.05 lyase 1 C17(Carbamidomethyl) 2-hydroxyacyl-CoA N-Term(Dimethyl); M5(Oxidation); NQEAMGAFQEFPQVEACR D3YZ54 2 2155.949 4.88 lyase 1 C17(Carbamidomethyl) 2-hydroxyacyl-CoA N-Term(Dimethyl:2H(6)13C(2)); NQEAMGAFQEFPQVEACR D3YZ54 8 2148.001 6.22 lyase 1 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-hydroxyacyl-CoA NQEAMGAFQEFPQVEACRLYTK D3YZ54 C17(Carbamidomethyl); 1 2689.363 2.96 lyase 1 K22(HeavyDimethyl) N-Term(Dimethyl); C5(Carbamidomethyl); NQESCGSCYSFASMGMLEAR P97821 Dipeptidyl peptidase 1 1 2344.915 2.48 C8(Carbamidomethyl); M14(Oxidation); M16(Oxidation) Isoform 4 of Regulator N-Term(Dimethyl:2H(6)13C(2)); NQLWVGIVPRGPDGVQLSSAYDK Q0VGM9-4 of telomere elongation 1 2571.423 2.43 K23(HeavyDimethyl) helicase 1 N-Term(Dimethyl:2H(6)13C(2)); NQNVQPHTFCFHAKPQQNRTIQGTGR E9PWP9 Protein 4931408C20Rik C10(Carbamidomethyl); 1 3136.638 2.66 K14(HeavyDimethyl) N-Term(Dimethyl); NQQEGVCPEGSIDNSPVK Q921I1 Serotransferrin 5 2013.948 4.31 C7(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NQQEGVCPEGSIDNSPVK Q921I1 Serotransferrin C7(Carbamidomethyl); 5 2030.041 4.42 K18(HeavyDimethyl) N-Term(Dimethyl); NQQEGVCPEGSIDNSPVKWCALSHLER Q921I1 Serotransferrin C7(Carbamidomethyl); K18(Dimethyl); 6 3166.502 4.62 C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); NQQEGVCPEGSIDNSPVKWCALSHLER Q921I1 Serotransferrin 16 3182.598 4.44 K18(HeavyDimethyl); C20(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); NQSFCPTVNLDKLWTLVSEQTR P14115 2 2692.376 2.78 L27a C5(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein NQSFCPTVNLDKLWTLVSEQTR P14115 C5(Carbamidomethyl); 4 2708.470 4.02 L27a K12(HeavyDimethyl) L-lactate dehydrogenase N-Term(Dimethyl); NRVIGSGCNLDSAR P06151 2 1546.773 2.48 A chain C8(Carbamidomethyl) L-lactate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); NRVIGSGCNLDSAR P06151 2 1554.820 2.31 A chain C8(Carbamidomethyl) Glycerol-3-phosphate N-Term(Dimethyl:2H(6)13C(2)); NSASVGIIQRDESPMEK Q8C0N2 1 1933.053 2.25 acyltransferase 3 K17(HeavyDimethyl) 1,4-alpha-glucan- N-Term(Dimethyl); NSEDGLNMFDGTDSCYFHSGPR G3UW30 2 2534.030 3.53 branching enzyme C15(Carbamidomethyl) 1,4-alpha-glucan- N-Term(Dimethyl:2H(6)13C(2)); NSEDGLNMFDGTDSCYFHSGPR G3UW30 3 2542.067 2.80 branching enzyme C15(Carbamidomethyl) Adenylyl cyclase- N-Term(Dimethyl); NSLDCEIVSAK P40124 3 1291.652 2.47 associated protein 1 C5(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenylyl cyclase- NSLDCEIVSAK P40124 C5(Carbamidomethyl); 2 1307.742 2.13 associated protein 1 K11(HeavyDimethyl) N-Term(Dimethyl); M14(Oxidation); NSPVEGAPLSGQDMTLKKHVFFMNAC Choline transporter-like K17(Dimethyl); K18(Dimethyl); Q921V7 1 3605.834 3.01 NLEVK protein 3 M23(Oxidation); C26(Carbamidomethyl); K31(Dimethyl) BMP/retinoic acid- NSSLDPMFFVYVNPFSGSHSEGWNMP Q920P3 inducible neural-specific M7(Oxidation); M25(Oxidation) 2 3931.753 2.99 FGEFGYPR protein 1 Isoform 2 of Proto- N-Term(Dimethyl:2H(6)13C(2)); NSSSLDHPDERVLTMGDLISFAWQISR oncogene tyrosine- P35546-2 M29(Oxidation); M35(Oxidation); 1 4230.091 3.41 GMQYLAEMK protein kinase receptor K36(HeavyDimethyl) Ret NSSTKIQVSSQNPPPSPMPGRVSAAPA E9QAF9 Protein TANC1 K5(Dimethyl) 1 3075.589 3.08 VSR Isoform 2 of Anaphase- NTEMVISVLLSVAELYWRSSSPTIAMP M4(Oxidation); M26(Oxidation); Q8BTZ4-2 promoting complex 1 4540.461 3.14 VLLEALALSKEYR K37(Dimethyl) subunit 5 Ethylmalonyl-CoA N-Term(Dimethyl); NTFCSGSDLNAVK E0CXS3 decarboxylase 1 1468.709 2.11 C4(Carbamidomethyl); K13(Dimethyl) (Fragment) Ethylmalonyl-CoA N-Term(Dimethyl:2H(6)13C(2)); NTFCSGSDLNAVK E0CXS3 decarboxylase C4(Carbamidomethyl); 1 1484.800 2.15 (Fragment) K13(HeavyDimethyl) N-Term(Dimethyl); NTGIICTIGPASR P52480 Pyruvate kinase PKM 2 1387.735 2.52 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NTGIICTIGPASR P52480 Pyruvate kinase PKM 1 1395.780 2.42 C6(Carbamidomethyl) Isoform 2 of Zinc finger C10(Carbamidomethyl); NTIQITVTACCCSHLFVLQLVHRPSVR Q8CIE2-2 MIZ domain-containing C11(Carbamidomethyl); 1 3209.628 2.67 protein 2 C12(Carbamidomethyl) NTKVSEVSSLSELTNSTDIAGSMDITDI D3YV92 Protein Fam71d N-Term(Dimethyl); K3(Dimethyl) 1 3458.695 3.28 TAFR Protein Slc25a1 N-Term(Dimethyl); NTLDCGLK F6VVY4 4 976.513 2.30 (Fragment) C5(Carbamidomethyl); K8(Dimethyl) Isoform 2 of Rab GDP N-Term(Dimethyl); NTNDANSCQIIIPQNQVNR Q61598-2 dissociation inhibitor 4 2227.081 2.96 C8(Carbamidomethyl) beta Isoform 2 of Rab GDP N-Term(Dimethyl:2H(6)13C(2)); NTNDANSCQIIIPQNQVNR Q61598-2 dissociation inhibitor 1 2235.127 2.58 C8(Carbamidomethyl) beta NTQFVLCHYVVSRDPSVFPEPNSFQPH Sterol 26-hydroxylase, N-Term(Dimethyl); Q9DBG1 4 3385.651 3.30 R mitochondrial C7(Carbamidomethyl) NTQFVLCHYVVSRDPSVFPEPNSFQPH Sterol 26-hydroxylase, N-Term(Dimethyl:2H(6)13C(2)); Q9DBG1 1 3393.704 3.73 R mitochondrial C7(Carbamidomethyl) Translation initiation NTSSEPPEYQLMTGEQIHQERLKLR Q9CZD5 factor IF-3, K23(HeavyDimethyl) 1 3020.601 2.77 mitochondrial Succinate dehydrogenase NTVIATGGYGRTYFSCTSAHTSTGDGT N-Term(Dimethyl); Q8K2B3 [ubiquinone] 1 3368.563 2.87 AMVTR C16(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase NTVIATGGYGRTYFSCTSAHTSTGDGT N-Term(Dimethyl:2H(6)13C(2)); Q8K2B3 [ubiquinone] 1 3376.601 4.22 AMVTR C16(Carbamidomethyl) flavoprotein subunit, mitochondrial Alanine--tRNA ligase, N-Term(Dimethyl); NVGCLQEALQLATSFAQLR Q8BGQ7 5 2147.140 5.08 cytoplasmic C4(Carbamidomethyl) Alanine--tRNA ligase, N-Term(Dimethyl:2H(6)13C(2)); NVGCLQEALQLATSFAQLR Q8BGQ7 5 2155.186 4.19 cytoplasmic C4(Carbamidomethyl) N-Term(Dimethyl); DnaJ homolog subfamily NVICDKCEGR P63037 C4(Carbamidomethyl); K6(Dimethyl); 3 1306.621 2.88 A member 1 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); DnaJ homolog subfamily C4(Carbamidomethyl); NVICDKCEGR P63037 1 1322.710 2.42 A member 1 K6(HeavyDimethyl); C7(Carbamidomethyl) N-Term(Dimethyl); DnaJ homolog subfamily NVLCSACSGQGGK Q9QYJ0 C4(Carbamidomethyl); 2 1393.651 3.12 A member 2 C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); DnaJ homolog subfamily C4(Carbamidomethyl); NVLCSACSGQGGK Q9QYJ0 3 1409.740 2.34 A member 2 C7(Carbamidomethyl); K13(HeavyDimethyl) UDP- N-Term(Dimethyl); NVLLAVSENFMCR Q63886 glucuronosyltransferase 5 1580.786 3.54 C12(Carbamidomethyl) 1-1 UDP- N-Term(Dimethyl:2H(6)13C(2)); NVLLAVSENFMCR Q63886 glucuronosyltransferase 7 1588.838 3.71 C12(Carbamidomethyl) 1-1 M18(Oxidation); K20(Dimethyl); NVPATGTGSLQPSSGTQMAKLPLQKR J3QK40 Protein Gm8674 1 2739.442 2.52 K25(Dimethyl) NVSAFPGLPKQPILAGNPRMMDSQEN Nuclear receptor O09000 K10(Dimethyl); M31(Oxidation) 1 3815.837 3.40 YGANMGPNR coactivator 3 Isoform 2 of Dynein C6(Carbamidomethyl); NVSSACEGLCKWVR Q8BW94-2 1 1693.815 2.33 heavy chain 3, axonemal C10(Carbamidomethyl); K11(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl); K6(Dimethyl); NVVSGKTSACFEPSLDYMVTK Q8C196 synthase [ammonia], 4 2417.210 4.01 C10(Carbamidomethyl); K21(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); K6(Dimethyl); NVVSGKTSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 6 2783.440 5.12 C10(Carbamidomethyl); K21(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); K6(Dimethyl); NVVSGKTSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], C10(Carbamidomethyl); 5 2799.422 3.88 mitochondrial M18(Oxidation); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K6(HeavyDimethyl); NVVSGKTSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 5 2807.584 4.76 C10(Carbamidomethyl); mitochondrial K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K6(HeavyDimethyl); NVVSGKTSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 3 2823.559 2.96 C10(Carbamidomethyl); mitochondrial M18(Oxidation); K21(HeavyDimethyl) Bile acid-CoA:amino N-Term(Dimethyl); NWTLLSYPGAGHLIEPPYTPLCQASR Q91X34 1 2969.508 2.95 acid N-acyltransferase C22(Carbamidomethyl) Bile acid-CoA:amino N-Term(Dimethyl:2H(6)13C(2)); NWTLLSYPGAGHLIEPPYTPLCQASR Q91X34 1 2977.547 3.72 acid N-acyltransferase C22(Carbamidomethyl) N-Term(Dimethyl); NYCRNPDGDVNGPWCYTTNPR P20918 Plasminogen C3(Carbamidomethyl); 1 2584.096 2.99 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NYCRNPDGDVNGPWCYTTNPR P20918 Plasminogen C3(Carbamidomethyl); 2 2592.142 2.94 C15(Carbamidomethyl) Glycine N- NYDYILSTGCAPPGK Q9QXF8 C10(Carbamidomethyl); K15(Dimethyl) 1 1683.797 2.53 methyltransferase Glycine N- N-Term(Dimethyl); NYDYILSTGCAPPGK Q9QXF8 33 1711.827 5.65 methyltransferase C10(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glycine N- NYDYILSTGCAPPGK Q9QXF8 C10(Carbamidomethyl); 29 1727.918 5.96 methyltransferase K15(HeavyDimethyl) N-Term(Dimethyl); Glycine N- NYDYILSTGCAPPGKNIYYK Q9QXF8 C10(Carbamidomethyl); K15(Dimethyl); 7 2421.213 4.27 methyltransferase K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glycine N- C10(Carbamidomethyl); NYDYILSTGCAPPGKNIYYK Q9QXF8 16 2445.351 4.62 methyltransferase K15(HeavyDimethyl); K20(HeavyDimethyl) N-Term(Dimethyl); Glycine N- NYDYILSTGCAPPGKNIYYKSDLTK Q9QXF8 C10(Carbamidomethyl); K15(Dimethyl); 7 2993.535 4.70 methyltransferase K20(Dimethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); Glycine N- NYDYILSTGCAPPGKNIYYKSDLTK Q9QXF8 K15(HeavyDimethyl); 5 3025.717 4.23 methyltransferase K20(HeavyDimethyl); K25(HeavyDimethyl) NYIALKSEGDDYYINGAWTIDWPRK D3Z1A5 Protein Adamts6 K6(Dimethyl); K25(Dimethyl) 1 3044.545 2.61 N-Term(Dimethyl); C8(Carbamidomethyl); NYLEDSNCYCDSFHSCLYYSKCFNNN Protein Gm732 C10(Carbamidomethyl); B1ATX8 1 4033.714 2.97 VSMNK (Fragment) C16(Carbamidomethyl); K21(Dimethyl); C22(Carbamidomethyl); M29(Oxidation); K31(Dimethyl) Sarcoplasmic/endoplasm N-Term(Dimethyl); K8(Dimethyl); NYLEQPGKECVQPATK O55143 ic reticulum calcium 3 1945.994 3.22 C10(Carbamidomethyl); K16(Dimethyl) ATPase 2 N-Term(Dimethyl:2H(6)13C(2)); Sarcoplasmic/endoplasm K8(HeavyDimethyl); NYLEQPGKECVQPATK O55143 ic reticulum calcium 2 1970.133 2.62 C10(Carbamidomethyl); ATPase 2 K16(HeavyDimethyl) GTP-binding protein N-Term(Dimethyl); NYLPAINGIVFLVDCADHER Q9CQC9 3 2344.177 2.84 SAR1b C15(Carbamidomethyl) GTP-binding protein N-Term(Dimethyl:2H(6)13C(2)); NYLPAINGIVFLVDCADHER Q9CQC9 1 2352.234 2.83 SAR1b C15(Carbamidomethyl) GTP-binding protein N-Term(Dimethyl); NYLPAINGIVFLVDCADHSR P36536 1 2302.171 2.61 SAR1a C15(Carbamidomethyl) GTP-binding protein N-Term(Dimethyl:2H(6)13C(2)); NYLPAINGIVFLVDCADHSR P36536 1 2310.224 2.84 SAR1a C15(Carbamidomethyl) Transitional N-Term(Dimethyl); QAAPCVLFFDELDSIAK Q01853 endoplasmic reticulum 19 1980.025 4.89 C5(Carbamidomethyl); K17(Dimethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); QAAPCVLFFDELDSIAK Q01853 endoplasmic reticulum C5(Carbamidomethyl); 13 1996.108 4.42 ATPase K17(HeavyDimethyl) Transitional N-Term(Dimethyl); QAAPCVLFFDELDSIAKAR Q01853 endoplasmic reticulum 6 2207.161 5.52 C5(Carbamidomethyl); K17(Dimethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); QAAPCVLFFDELDSIAKAR Q01853 endoplasmic reticulum C5(Carbamidomethyl); 10 2223.247 6.32 ATPase K17(HeavyDimethyl) 4- N-Term(Dimethyl); QAASFYCNK P49429 hydroxyphenylpyruvate 1 1144.541 2.11 C7(Carbamidomethyl); K9(Dimethyl) dioxygenase 4- N-Term(Dimethyl:2H(6)13C(2)); QAASFYCNK P49429 hydroxyphenylpyruvate C7(Carbamidomethyl); 2 1160.635 2.07 dioxygenase K9(HeavyDimethyl) Late secretory pathway N-Term(Dimethyl:2H(6)13C(2)); QADITRETVQK Q80U56 1 1360.844 1.92 protein AVL9 homolog K11(HeavyDimethyl)

QAFTDVATGSLGQGLGAACGMAYTG N-Term(Dimethyl); P40142 Transketolase 1 2588.251 4.51 K C19(Carbamidomethyl); K26(Dimethyl)

Enoyl-CoA hydratase, N-Term(Dimethyl); K7(Dimethyl); QAGLVSKIFPVEKLVEEAIQCAEK F6T930 mitochondrial K13(Dimethyl); C21(Carbamidomethyl); 1 2798.589 3.28 (Fragment) K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Enoyl-CoA hydratase, K7(HeavyDimethyl); QAGLVSKIFPVEKLVEEAIQCAEK F6T930 mitochondrial K13(HeavyDimethyl); 1 2830.772 3.58 (Fragment) C21(Carbamidomethyl); K24(HeavyDimethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); QAGNNQPFTLDDVQYMIFHTPFCK P54869 CoA synthase, 6 2927.362 4.71 C23(Carbamidomethyl); K24(Dimethyl) mitochondrial Hydroxymethylglutaryl- N-Term(Dimethyl:2H(6)13C(2)); QAGNNQPFTLDDVQYMIFHTPFCK P54869 CoA synthase, C23(Carbamidomethyl); 17 2943.485 5.07 mitochondrial K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxymethylglutaryl- M16(Oxidation); QAGNNQPFTLDDVQYMIFHTPFCK P54869 CoA synthase, 1 2959.470 2.92 C23(Carbamidomethyl); mitochondrial K24(HeavyDimethyl) Hydroxymethylglutaryl- N-Term(Dimethyl); QAGNNQPFTLDDVQYMIFHTPFCKMV P54869 CoA synthase, C23(Carbamidomethyl); K24(Dimethyl); 1 3441.699 3.48 QK mitochondrial K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxymethylglutaryl- QAGNNQPFTLDDVQYMIFHTPFCKMV C23(Carbamidomethyl); P54869 CoA synthase, 1 3465.826 3.39 QK K24(HeavyDimethyl); mitochondrial K28(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein C5(Carbamidomethyl); QAHLCVLASNCDEPMYVK P63323 4 2207.132 3.49 S12 C11(Carbamidomethyl); K18(HeavyDimethyl) QALAWPDRVALVCTGSEGSSITNSQLD Bile acyl-CoA N-Term(Dimethyl); Q4LDG0 3 3130.578 5.96 AR synthetase C13(Carbamidomethyl) QALAWPDRVALVCTGSEGSSITNSQLD Bile acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); Q4LDG0 3 3138.608 6.62 AR synthetase C13(Carbamidomethyl) QALNEISARHSEIQQLER P70452 Syntaxin-4 2 2122.096 2.50 2-hydroxyacyl-CoA N-Term(Dimethyl); K8(Dimethyl); QALQDTSKPCLLNIMIEPQSTR D3YZ54 2 2599.356 2.80 lyase 1 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-hydroxyacyl-CoA QALQDTSKPCLLNIMIEPQSTR D3YZ54 K8(HeavyDimethyl); 1 2615.443 3.37 lyase 1 C10(Carbamidomethyl) Probable N-Term(Dimethyl); QASEEELFCSFQQR Q9DBA8 5 1786.795 4.11 imidazolonepropionase C9(Carbamidomethyl)

Probable N-Term(Dimethyl:2H(6)13C(2)); QASEEELFCSFQQR Q9DBA8 5 1794.841 2.93 imidazolonepropionase C9(Carbamidomethyl) Acetyl-CoA N-Term(Dimethyl); QATLGAGLPISTPCTTVNK Q8QZT1 acetyltransferase, 1 1985.068 3.78 C14(Carbamidomethyl); K19(Dimethyl) mitochondrial Acetyl-CoA N-Term(Dimethyl:2H(6)13C(2)); QATLGAGLPISTPCTTVNK Q8QZT1 acetyltransferase, C14(Carbamidomethyl); 2 2001.159 3.51 mitochondrial K19(HeavyDimethyl)

Acetyl-CoA N-Term(Dimethyl); QATLGAGLPISTPCTTVNKVCASGMK Q8QZT1 acetyltransferase, C14(Carbamidomethyl); K19(Dimethyl); 3 2746.433 4.14 mitochondrial C21(Carbamidomethyl); K26(Dimethyl)

N-Term(Dimethyl); Acetyl-CoA C14(Carbamidomethyl); K19(Dimethyl); QATLGAGLPISTPCTTVNKVCASGMK Q8QZT1 acetyltransferase, 1 2762.419 3.31 C21(Carbamidomethyl); mitochondrial M25(Oxidation); K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acetyl-CoA C14(Carbamidomethyl); QATLGAGLPISTPCTTVNKVCASGMK Q8QZT1 acetyltransferase, K19(HeavyDimethyl); 9 2770.556 4.40 mitochondrial C21(Carbamidomethyl); K26(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acetyl-CoA C14(Carbamidomethyl); QATLGAGLPISTPCTTVNKVCASGMK Q8QZT1 acetyltransferase, K19(HeavyDimethyl); 4 2786.550 3.17 mitochondrial C21(Carbamidomethyl); M25(Oxidation); K26(HeavyDimethyl) MCG21756, isoform QCLGLLSRFGGADRLR B9EJ54 C2(Carbamidomethyl) 1 1818.952 2.25 CRA_b N-Term(Dimethyl); QCVPLNLTEPSLRSK Q7TSY8 Shugoshin-like 2 2 1797.998 2.94 C2(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl); QDGPAAGAAGFMVPCTR B1APN4 Protein Rhox1 1 1733.813 2.29 C15(Carbamidomethyl) Collagen alpha-1(XI) N-Term(Dimethyl); M6(Oxidation); QDIEHMKFPMGTQTNPAR V9GWX8 1 2173.062 2.46 chain (Fragment) K7(Dimethyl) N-Term(Dimethyl); QDLSFVTASCLDEVLNAAFDGGFPVKT Lon protease homolog 2, Q8BK80 C10(Carbamidomethyl); K26(Dimethyl); 1 3851.962 3.06 RPGLIDSK peroxisomal K35(Dimethyl) K17(HeavyDimethyl); Ribosome biogenesis QDLYMWLSNSPHGPSAKFLVQNIHTL K30(HeavyDimethyl); F6WEP7 protein BRX1 homolog 1 4350.411 3.14 AELKMTGNCLK C35(Carbamidomethyl); (Fragment) K37(HeavyDimethyl) Transketolase-like QEDPENPDNDRCILSK D6REV0 C12(Carbamidomethyl); K16(Dimethyl) 1 1957.920 2.32 protein 1 Isoform Short of QEEFDIANNGSSQANK Q64514-2 N-Term(Dimethyl); K16(Dimethyl) 1 1807.863 2.34 Tripeptidyl-peptidase 2 Isoform 3 of QEEGTKRAEDQGGCR Q5DU14-3 Unconventional myosin- K6(Dimethyl); C14(Carbamidomethyl) 1 1748.787 2.20 XVI M4(Oxidation); M6(Oxidation); QELMSMKEVGDGLQDQMNCMMGAL K7(HeavyDimethyl); Q80VY2 Protein FAM212B 1 3318.606 2.90 QELK C19(Carbamidomethyl); K28(HeavyDimethyl) Isoform 3 of Pre-mRNA- N-Term(Dimethyl); QELSHALYQHDAACR Q99KP6-3 2 1826.854 2.90 processing factor 19 C14(Carbamidomethyl)

Isoform 3 of Hepatocyte QFNQTVQSSGNMTDK P27889-3 K15(Dimethyl) 1 1712.789 2.20 nuclear factor 1-beta Isoform 2 of DENN QFPPDFQEQEAMQMVPR Q8CFK6-2 domain-containing N-Term(Dimethyl); M14(Oxidation) 1 2121.967 2.38 protein 1C N-Term(Dimethyl:2H(6)13C(2)); QFPVTCETGPGSPSGHAMGAAGVYYV P35576 Glucose-6-phosphatase C6(Carbamidomethyl); M27(Oxidation); 1 4033.095 2.78 MVTSTLAIFRGK K38(HeavyDimethyl) Probable N-Term(Dimethyl); QFSGETFEERIDCSGK Q9DBA8 5 1945.888 3.15 imidazolonepropionase C13(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Probable QFSGETFEERIDCSGK Q9DBA8 C13(Carbamidomethyl); 3 1961.984 3.31 imidazolonepropionase K16(HeavyDimethyl) Isoform Beta of Heat QFSIDPDLLVDSENK P38533-2 N-Term(Dimethyl); K15(Dimethyl) 1 1775.921 2.32 shock factor protein 2 Electron transfer N-Term(Dimethyl); QFSYTHICAGASAFGK Q99LC5 flavoprotein subunit 1 1800.869 2.75 C8(Carbamidomethyl); K16(Dimethyl) alpha, mitochondrial Electron transfer N-Term(Dimethyl:2H(6)13C(2)); QFSYTHICAGASAFGK Q99LC5 flavoprotein subunit C8(Carbamidomethyl); 1 1816.954 2.31 alpha, mitochondrial K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C7(Carbamidomethyl); QFTVFNCTLPSNTSIDKIFGIIGCGYFDP Isoform 2 of Dynein K17(HeavyDimethyl); Q91XQ0-2 1 3864.038 3.05 CRK heavy chain 8, axonemal C24(Carbamidomethyl); C30(Carbamidomethyl); K32(HeavyDimethyl) N-Term(Dimethyl); QGAALGIPYFTACR P47199 Quinone oxidoreductase 1 1552.796 2.31 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QGAALGIPYFTACR P47199 Quinone oxidoreductase 2 1560.839 2.28 C13(Carbamidomethyl) QGAMNTAQQNTSDNWSGGNAPPPVE Lysine-specific C32(Carbamidomethyl); O70546 1 4101.858 2.66 QQTHSWCLTPQK demethylase 6A K37(HeavyDimethyl) N-Term(Dimethyl); QGANIVSLPECFNSPYGTTYFPDYAEKI Q9JHW2 Omega-amidase NIT2 C11(Carbamidomethyl); K27(Dimethyl); 1 3992.944 3.06 PGESTQK K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); QGAVVLHVLCAMYMFYALAIVCDDFF Sodium/potassium/calciu M12(Oxidation); Q8VD29 1 4353.220 2.70 VPSLEKICER m exchanger 3 C22(Carbamidomethyl); K32(HeavyDimethyl); C34(Carbamidomethyl) Ribosyldihydronicotina N-Term(Dimethyl:2H(6)13C(2)); QGCTVTVSDLYSMNFEPR Q9JI75 mide dehydrogenase 1 2140.021 3.07 C3(Carbamidomethyl) [quinone] N-Term(Dimethyl); Bile acyl-CoA QGFCIPVEPGKPGLLLTK Q4LDG0 C4(Carbamidomethyl); K11(Dimethyl); 5 2038.183 3.48 synthetase K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Bile acyl-CoA C4(Carbamidomethyl); QGFCIPVEPGKPGLLLTK Q4LDG0 4 2062.313 3.68 synthetase K11(HeavyDimethyl); K18(HeavyDimethyl) C-1-tetrahydrofolate N-Term(Dimethyl); QGFGNLPICMAK Q922D8 3 1391.721 2.73 synthase, cytoplasmic C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); C-1-tetrahydrofolate QGFGNLPICMAK Q922D8 C9(Carbamidomethyl); M10(Oxidation); 1 1407.710 2.22 synthase, cytoplasmic K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-1-tetrahydrofolate QGFGNLPICMAK Q922D8 C9(Carbamidomethyl); 5 1407.798 2.98 synthase, cytoplasmic K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-1-tetrahydrofolate QGFGNLPICMAK Q922D8 C9(Carbamidomethyl); M10(Oxidation); 2 1423.798 2.14 synthase, cytoplasmic K12(HeavyDimethyl)

QGGFLPGGGSLHSAMTPHGPDADCFE Homogentisate 1,2- N-Term(Dimethyl); O09173 6 2826.295 4.74 K dioxygenase C24(Carbamidomethyl); K27(Dimethyl)

QGGFLPGGGSLHSAMTPHGPDADCFE Homogentisate 1,2- N-Term(Dimethyl); M15(Oxidation); O09173 1 2842.280 2.77 K dioxygenase C24(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); QGGFLPGGGSLHSAMTPHGPDADCFE Homogentisate 1,2- O09173 C24(Carbamidomethyl); 10 2842.379 4.96 K dioxygenase K27(HeavyDimethyl) N-Term(Dimethyl); QGGFLPGGGSLHSAMTPHGPDADCFE Homogentisate 1,2- O09173 C24(Carbamidomethyl); K27(Dimethyl); 1 3140.488 3.64 KASK dioxygenase K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); QGGFLPGGGSLHSAMTPHGPDADCFE Homogentisate 1,2- C24(Carbamidomethyl); O09173 5 3164.612 3.83 KASK dioxygenase K27(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl); K6(Dimethyl); QGLGLKFAELVYTGFWHSPECEFVR J3QNG0 MCG15755 7 3026.546 4.17 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QGLGLKFAELVYTGFWHSPECEFVR J3QNG0 MCG15755 K6(HeavyDimethyl); 14 3042.619 5.31 C21(Carbamidomethyl) AT-rich interactive N-Term(Dimethyl:2H(6)13C(2)); QGPQTRESQFLYASK Q3V3M5 domain-containing 1 1812.033 2.09 K15(HeavyDimethyl) protein 3B

K17(Dimethyl); C18(Carbamidomethyl); QGQFNFVHVIITPLDYKCNLLTLQCRK Q61037-7 Isoform F of Tuberin 1 3361.744 3.30 C25(Carbamidomethyl); K27(Dimethyl)

QGQIQSYMLLGGQWENEGLSGELEGL E9Q7D5 Protein Arhgef5 N-Term(Dimethyl); M8(Oxidation) 1 4399.022 3.21 NYSERGQENRER ATP-binding cassette QGRTIILSTHHMDEADILGDR P41233 N-Term(Dimethyl); M12(Oxidation) 1 2422.227 2.83 sub-family A member 1 N-Term(Dimethyl); M7(Oxidation); QHTASWMCLSLLAALASSAGDTWASE Transmembrane protein Q91W52 C8(Carbamidomethyl); K33(Dimethyl); 1 4857.477 3.55 VAPVLSKSSPRLITTWEK 19 K44(Dimethyl) QHVIAGEHMLENAGPPSTRR Q8R4Y4-2 Isoform 2 of Stabilin-1 N-Term(Dimethyl) 1 2228.103 2.38 N-Term(Dimethyl); QIDDVLSVASVRPAVLQVECHPYLAQ Alcohol dehydrogenase B1AXW3 C20(Carbamidomethyl); 1 4137.114 4.54 NELIAHCHAR [NADP(+)] (Fragment) C33(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QIDDVLSVASVRPAVLQVECHPYLAQ Alcohol dehydrogenase B1AXW3 C20(Carbamidomethyl); 1 4145.152 4.86 NELIAHCHAR [NADP(+)] (Fragment) C33(Carbamidomethyl) QIILAEAEGSVPFLVSATSGTTVLGAFD Cysteine sulfinic acid N-Term(Dimethyl); Q9DBE0 1 4060.114 4.56 PLDAIADVCQR decarboxylase C37(Carbamidomethyl) QIIVEEAKQILVGDIGDTVEDPYTSFVK N-Term(Dimethyl); K8(Dimethyl); P45591 Cofilin-2 1 4172.252 3.47 LLPLNDCR K28(Dimethyl); C35(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QILCVGLVVLDIINVVDKYPEEDTDRR P97328 Ketohexokinase C4(Carbamidomethyl); 1 3243.834 4.01 K18(HeavyDimethyl) QILVGDIGDTVEDPYTSFVKLLPLNDC N-Term(Dimethyl); K20(Dimethyl); P45591 Cofilin-2 2 3233.685 3.52 R C27(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QILVGDIGDTVEDPYTSFVKLLPLNDC P45591 Cofilin-2 K20(HeavyDimethyl); 1 3249.786 3.75 R C27(Carbamidomethyl) QINSAELSGSEDPIFLYPIVLNWTVKGA N-Term(Dimethyl); K26(Dimethyl); E9PUV7 Protein 4930485B16Rik 1 3920.115 3.53 MKEVMK K30(Dimethyl); K34(Dimethyl) QIPDLYPDRNESQISKIPR Q7TSY8 Shugoshin-like 2 N-Term(Dimethyl); K16(Dimethyl) 1 2325.230 2.27 QIRDQVLSIFWK Q7TRP3 Olfactory receptor K12(HeavyDimethyl) 1 1568.923 2.46 Carbamoyl-phosphate N-Term(Dimethyl); K4(Dimethyl); QISKCLGLTEAQTR Q8C196 synthase [ammonia], 5 1660.898 3.41 C5(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); QISKCLGLTEAQTR Q8C196 synthase [ammonia], K4(HeavyDimethyl); 2 1676.991 2.79 mitochondrial C5(Carbamidomethyl) Serine/threonine-protein N-Term(Dimethyl); QITQVYGFYDECQTK Q9CQR6 phosphatase 6 catalytic 1 1935.908 2.68 C12(Carbamidomethyl); K15(Dimethyl) subunit Uncharacterized protein QIYSQLLRATANRNSTLLER H3BJF7 2 2347.254 2.29 (Fragment) Dihydropyrimidine N-Term(Dimethyl); K2(Dimethyl); QKDQNTACSPLQR Q8CHR6 dehydrogenase 1 1601.799 2.79 C8(Carbamidomethyl) [NADP(+)] Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); QKDQNTACSPLQR Q8CHR6 dehydrogenase K2(HeavyDimethyl); 1 1617.888 2.27 [NADP(+)] C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropyrimidine K2(HeavyDimethyl); QKDQNTACSPLQRK Q8CHR6 dehydrogenase 2 1782.068 3.10 C8(Carbamidomethyl); [NADP(+)] K14(HeavyDimethyl) Isoform 3 of Rho QKEPAGESGQHNR Q8C4V1-3 GTPase-activating K2(HeavyDimethyl) 1 1473.746 1.98 protein 24 Glutaryl-CoA QKYLPGLAKGELLGCFGLTEPNHGSDP N-Term(Dimethyl); K2(Dimethyl); Q60759 dehydrogenase, 1 3613.808 3.13 GGMETR K9(Dimethyl); C15(Carbamidomethyl) mitochondrial Lysosomal alpha- N-Term(Dimethyl); QLAAGWGPCEVLVSNALAR O09159 2 2040.074 2.87 mannosidase C9(Carbamidomethyl) Lysosomal alpha- N-Term(Dimethyl:2H(6)13C(2)); QLAAGWGPCEVLVSNALAR O09159 3 2048.116 2.93 mannosidase C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Methyltransferase-like QLADSSMDVVVCTLVLCSVQSPR Q9DD20 C12(Carbamidomethyl); 1 2600.319 3.23 protein 7B C17(Carbamidomethyl) T-complex protein 1 N-Term(Dimethyl); QLCDNAGFDATNILNK P80313 6 1849.907 4.04 subunit eta C3(Carbamidomethyl); K16(Dimethyl) T-complex protein 1 N-Term(Dimethyl); QLCDNAGFDATNILNKLR P80313 2 2119.102 2.82 subunit eta C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 QLCDNAGFDATNILNKLR P80313 C3(Carbamidomethyl); 1 2135.194 2.62 subunit eta K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); QLDVPSSQCPSIAQTSEPGTQLPDLSGL C9(Carbamidomethyl); Q3V1D8 Protein Zfp408 1 4623.334 2.90 LCSPLDPAGSSSKLGR C30(Carbamidomethyl); K41(HeavyDimethyl) QLELKLPTPQLSLEDSISPLSAAVSQDI Tudor domain- N-Term(Dimethyl:2H(6)13C(2)); P61407 1 3492.998 3.03 QGSR containing protein 6 K5(HeavyDimethyl) ATP-dependent DNA N-Term(Dimethyl:2H(6)13C(2)); QLGISATMLNASSSK D3Z6T0 1 1595.923 2.24 helicase Q1 (Fragment) M8(Oxidation); K15(HeavyDimethyl) Isoform 2 of von Willebrand factor A M6(Oxidation); M11(Oxidation); QLLAEMVQSHMVK Q8CC88-2 1 1573.802 2.29 domain-containing K13(Dimethyl) protein 8 Alpha-aminoadipic N-Term(Dimethyl); QLLCDLVGISR Q99K67 semialdehyde synthase, 2 1301.726 2.42 C4(Carbamidomethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); QLLCDLVGISR Q99K67 semialdehyde synthase, 2 1309.770 2.93 C4(Carbamidomethyl) mitochondrial

2-hydroxyacyl-CoA N-Term(Dimethyl); K8(Dimethyl); QLLEQFDKTPWQCPPDSQWWK D3YZ54 2 2801.345 4.31 lyase 1 C13(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 2-hydroxyacyl-CoA K8(HeavyDimethyl); QLLEQFDKTPWQCPPDSQWWK D3YZ54 3 2825.505 3.32 lyase 1 C13(Carbamidomethyl); K21(HeavyDimethyl) Isoform 2 of BRCA1- QLPDQISFFSGNPSVEIVHGIMHLYK Q99MP8-2 M22(Oxidation); K26(HeavyDimethyl) 1 3008.542 3.23 associated protein N-Term(Dimethyl:2H(6)13C(2)); Alpha-2-HS- QLTEHAVEGDCDFHILKQDGQFR P29699 C11(Carbamidomethyl); 1 2815.426 2.81 glycoprotein K17(HeavyDimethyl) Tetratricopeptide repeat N-Term(Dimethyl); QLVLLNPYAALCNR Q8VBW8 10 1672.919 3.84 protein 36 C12(Carbamidomethyl) Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)); QLVLLNPYAALCNR Q8VBW8 10 1680.963 4.01 protein 36 C12(Carbamidomethyl) Bifunctional ATP- dependent N-Term(Dimethyl:2H(6)13C(2)); QMALVLDRICTTLIGLEEHLNALDRAA Q8VC30 dihydroxyacetone C10(Carbamidomethyl); 1 4202.091 3.44 GDGDCGSTHSR kinase/FAD-AMP lyase C32(Carbamidomethyl) (cyclizing) QMDAIDVTMHLDQLRTAILFQRISDIID Apolipoprotein B-100 N-Term(Dimethyl:2H(6)13C(2)); E9Q1Y3 1 3495.856 2.80 R (Fragment) M2(Oxidation); M9(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); F-actin-capping protein QMEKDETVSDCSPHIANIGR F7CAZ6 K4(HeavyDimethyl); 1 2359.191 2.66 subunit beta (Fragment) C11(Carbamidomethyl) Golgin subfamily A QMELESVSSELSEALR Q91VW5 1 1807.898 2.09 member 4 N-Term(Dimethyl:2H(6)13C(2)); Persulfide dioxygenase QMFEPKSCTYTYLLGDRESR Q9DCM0 K6(HeavyDimethyl); 1 2553.305 2.87 ETHE1, mitochondrial C8(Carbamidomethyl) Dolichol-phosphate QMNYTIGEVPISFVDR A2BDX2 mannosyltransferase N-Term(Dimethyl); M2(Oxidation) 1 1912.943 2.33 subunit 1 39S ribosomal protein N-Term(Dimethyl); QMQVLESCTATVGR B1B1D8 1 1607.782 2.53 L2, mitochondrial C8(Carbamidomethyl) Dynein heavy chain 12, N-Term(Dimethyl:2H(6)13C(2)); QMSEIVGYDLTPDSGTTLRK E9QPU2 1 2299.263 2.46 axonemal (Fragment) M2(Oxidation); K20(HeavyDimethyl) QNDSLQSAIADAEQQGEMAVR E9Q0F0 Protein Krt78 1 2261.049 2.29 N-Term(Dimethyl:2H(6)13C(2)); QNENTRNEKNDITADSNDPSSTDK E9PZM7 Protein Scaf11 K9(HeavyDimethyl); 2 2801.379 2.62 K24(HeavyDimethyl) Isoform 2 of Zinc finger K7(HeavyDimethyl); M11(Oxidation); QNSELMKTSRMFVQK P08043-2 1 1915.054 2.21 protein 2 K15(HeavyDimethyl) Isoform 2 of Zinc finger M6(Oxidation); K7(HeavyDimethyl); QNSELMKTSRMFVQK P08043-2 1 1915.050 2.04 protein 2 K15(HeavyDimethyl) DNA excision repair N-Term(Dimethyl); QNSGRGNGPVPNLLCLENMTSKSVR E9QPI9 protein ERCC-6-like 2 C15(Carbamidomethyl); 1 2800.396 2.82 (Fragment) M19(Oxidation); K22(Dimethyl) WD repeat-containing QNTQLELNITELLQKLRATDQEMR Q9D180 K15(Dimethyl); M23(Oxidation) 1 2929.508 2.93 protein 65 C-1-tetrahydrofolate N-Term(Dimethyl:2H(6)13C(2)); QNVFACVR Q922D8 1 1029.565 2.37 synthase, cytoplasmic C6(Carbamidomethyl) C-1-tetrahydrofolate N-Term(Dimethyl); QNVFACVRQPSQGPTFGIK Q922D8 1 2190.161 3.51 synthase, cytoplasmic C6(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-1-tetrahydrofolate QNVFACVRQPSQGPTFGIK Q922D8 C6(Carbamidomethyl); 1 2206.243 2.44 synthase, cytoplasmic K19(HeavyDimethyl) Dimethylaniline N-Term(Dimethyl); QPDFSTSGQWQVVTECEGK P97872 monooxygenase [N- 2 2239.032 4.51 C16(Carbamidomethyl); K19(Dimethyl) oxide-forming] 5 Dimethylaniline N-Term(Dimethyl:2H(6)13C(2)); QPDFSTSGQWQVVTECEGK P97872 monooxygenase [N- C16(Carbamidomethyl); 2 2255.109 4.12 oxide-forming] 5 K19(HeavyDimethyl) K3(HeavyDimethyl); QPKAPPTCNEPSDTQNSDAISTSSDLLN Period circadian protein O54943 C8(Carbamidomethyl); 1 4767.249 3.45 LLLGEDLCSATGSALSR homolog 2 C36(Carbamidomethyl) Apoptosis-stimulating of N-Term(Dimethyl:2H(6)13C(2)); QQDQRQQQQAAEQEK Q8CG79 1 1915.043 2.25 p53 protein 2 K15(HeavyDimethyl) N-Term(Dimethyl); QQELIQGICVK Q925N2 Sideroflexin-2 2 1371.768 2.20 C9(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); QQELIQGICVK Q925N2 Sideroflexin-2 C9(Carbamidomethyl); 1 1387.860 2.26 K11(HeavyDimethyl) QQELYFLPIVIEDSSYPVQSSTNTMTIR Q5RJH3 Cadherin-12 N-Term(Dimethyl:2H(6)13C(2)) 1 3295.671 3.37 Beta-1,3-galactosyl-O- glycosyl-glycoprotein C16(Carbamidomethyl); QQLFTEADYLRMTADCEHFKTK Q5JCT0 beta-1,6-N- K20(HeavyDimethyl); 1 2804.400 2.74 acetylglucosaminyltransf K22(HeavyDimethyl) erase 3 NADP-dependent malic N-Term(Dimethyl); QQLNIHGLLPPCIISQELQVLR P06801 3 2597.460 4.44 enzyme C12(Carbamidomethyl) NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); QQLNIHGLLPPCIISQELQVLR P06801 4 2605.497 4.06 enzyme C12(Carbamidomethyl) K7(HeavyDimethyl); M10(Oxidation); C24(Carbamidomethyl); QQLYMSKEMMEWAIDVDQILPSICSM L7N2B3 Protein Vmn2r68 M26(Oxidation); 1 4215.124 3.17 PCRPGLRK C28(Carbamidomethyl); K34(HeavyDimethyl) QQREEMDLMAWGVDAGSVEQHINSH E9PZW0 Desmoplakin M6(Oxidation); M9(Oxidation) 1 4211.985 2.76 RSIHNTIGDYR N-Term(Dimethyl:2H(6)13C(2)); QRDQTCTPVPVK Q9EQF5 Dihydropyrimidinase C6(Carbamidomethyl); 1 1500.876 2.51 K12(HeavyDimethyl) QRMHLRDGFLADQLDPIYVAYNM B7ZMZ7 Dip2c protein M3(Oxidation) 2 2782.323 2.94 Isoform 2 of Mitoferrin- QRMQMYNSPYHRVTDCVR Q8R0Z5-2 C16(Carbamidomethyl) 1 2341.108 2.62 2 N-Term(Dimethyl); Checkpoint protein QRPCLTLVVELASCPGHTR Q8K572 C4(Carbamidomethyl); 1 2222.148 2.39 HUS1B C14(Carbamidomethyl) Retinol-binding protein N-Term(Dimethyl:2H(6)13C(2)); QRQEELCLER Q00724 3 1396.736 2.22 4 C7(Carbamidomethyl) Nuclear receptor QRYETMQCFALSQPR O09000 C8(Carbamidomethyl) 2 1914.889 2.20 coactivator 3 M10(Oxidation); QSDSTTRIHMNLNGSVLLLNVTFLLSS Probable G-protein Q3V3Z3 C39(Carbamidomethyl); 1 4552.403 3.49 QMTLPTMPRPVCK coupled receptor 114 K40(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); AP-2 complex subunit QSIAIDDCTFHQCVR Q3TWV4 C8(Carbamidomethyl); 2 1885.903 2.77 mu C13(Carbamidomethyl) QSLGLSLNNLNITESVTSDILLDDTGDA Neuron navigator 3 F6SRT8 K32(HeavyDimethyl) 1 3705.864 3.54 TGHKDGR (Fragment) QTENAFSRSGGRASGDK E9Q0M9 Protein Cald1 K17(HeavyDimethyl) 1 1803.940 2.43 QTGWSQAALLQFLLGMCLTVMPPIQA Lysosomal acid B7ZCF4 C17(Carbamidomethyl) 2 3386.791 3.25 RSLR phosphatase (Fragment) QTPAQYLAQHEQLLLDASATSPVDSSE Isoform 2 of Protein O54972-2 N-Term(Dimethyl); K37(Dimethyl) 1 4065.049 2.96 LLLEVNENGK CBFA2T3 M10(Oxidation); QTPLLLLVYMVTTGSGRDRTDLLNVC Q05685 Folate receptor beta C26(Carbamidomethyl); 1 3448.764 2.86 MDAK M27(Oxidation); K30(HeavyDimethyl)

Gamma-butyrobetaine N-Term(Dimethyl); QTVTGGDSEIVDGFNVCQK Q924Y0 2 2110.012 5.01 dioxygenase C17(Carbamidomethyl); K19(Dimethyl)

Betaine--homocysteine S-N-Term(Dimethyl); QVADEGDALVAGGVSQTPSYLSCK O35490 19 2508.230 6.98 methyltransferase 1 C23(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- QVADEGDALVAGGVSQTPSYLSCK O35490 C23(Carbamidomethyl); 28 2524.316 7.72 methyltransferase 1 K24(HeavyDimethyl) N-Term(Dimethyl); QVADEGDALVAGGVSQTPSYLSCKSE Betaine--homocysteine S- O35490 C23(Carbamidomethyl); K24(Dimethyl); 31 3207.612 7.86 VEVK methyltransferase 1 K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); QVADEGDALVAGGVSQTPSYLSCKSE Betaine--homocysteine S-C23(Carbamidomethyl); O35490 20 3231.734 7.99 VEVK methyltransferase 1 K24(HeavyDimethyl); K30(HeavyDimethyl) N-Term(Dimethyl); QVADEGDALVAGGVSQTPSYLSCKSE Betaine--homocysteine S- O35490 C23(Carbamidomethyl); K24(Dimethyl); 17 3363.738 6.72 VEVKK methyltransferase 1 K30(Dimethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C23(Carbamidomethyl); QVADEGDALVAGGVSQTPSYLSCKSE Betaine--homocysteine S- O35490 K24(HeavyDimethyl); 6 3395.916 6.27 VEVKK methyltransferase 1 K30(HeavyDimethyl); K31(HeavyDimethyl) Aflatoxin B1 aldehyde N-Term(Dimethyl); QVEAELLPCLR Q8CG76 8 1355.736 3.41 reductase member 2 C9(Carbamidomethyl) Aflatoxin B1 aldehyde N-Term(Dimethyl:2H(6)13C(2)); QVEAELLPCLR Q8CG76 5 1363.780 2.86 reductase member 2 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); QVGGPVQAAAFRPGCPASSLAVQEAA Uncharacterized protein Q9CYS6 C15(Carbamidomethyl); 1 2891.478 2.63 CR C2orf72 homolog C27(Carbamidomethyl) Isoform 2 of Cytosol N-Term(Dimethyl); QVIDCQLADVNNLGK Q9CPY7-2 7 1742.904 4.32 aminopeptidase C5(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol QVIDCQLADVNNLGK Q9CPY7-2 C5(Carbamidomethyl); 7 1758.996 4.70 aminopeptidase K15(HeavyDimethyl) Isoform 2 of Cytosol N-Term(Dimethyl); QVIDCQLADVNNLGKYR Q9CPY7-2 7 2062.068 3.71 aminopeptidase C5(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol QVIDCQLADVNNLGKYR Q9CPY7-2 C5(Carbamidomethyl); 7 2078.158 4.61 aminopeptidase K15(HeavyDimethyl) Alanine N-Term(Dimethyl); QVLALCVYPNLLSSPDFPEDAK Q8QZR5 3 2532.318 4.10 aminotransferase 1 C6(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine QVLALCVYPNLLSSPDFPEDAK Q8QZR5 C6(Carbamidomethyl); 3 2548.398 5.58 aminotransferase 1 K22(HeavyDimethyl) Alanine N-Term(Dimethyl); QVLALCVYPNLLSSPDFPEDAKR Q8QZR5 3 2688.405 4.16 aminotransferase 1 C6(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine QVLALCVYPNLLSSPDFPEDAKR Q8QZR5 C6(Carbamidomethyl); 5 2704.489 5.34 aminotransferase 1 K22(HeavyDimethyl) Pyrroline-5-carboxylate N-Term(Dimethyl); QVLASAPTDNNLCHFR Q9DCC4 1 1870.919 3.15 reductase 3 C13(Carbamidomethyl)

Pyrroline-5-carboxylate N-Term(Dimethyl:2H(6)13C(2)); QVLASAPTDNNLCHFR Q9DCC4 1 1878.968 2.83 reductase 3 C13(Carbamidomethyl) Trifunctional purine N-Term(Dimethyl); QVLVAPGNAGTACAGK D6RCG1 biosynthetic protein 2 1569.838 2.64 C13(Carbamidomethyl); K16(Dimethyl) adenosine-3 Alanine N-Term(Dimethyl); QVMALCTYPNLLNSPSFPEDAK Q8BGT5 3 2551.258 3.99 aminotransferase 2 C6(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine QVMALCTYPNLLNSPSFPEDAK Q8BGT5 C6(Carbamidomethyl); 1 2567.361 3.42 aminotransferase 2 K22(HeavyDimethyl) Threonine--tRNA ligase, N-Term(Dimethyl); QVMVVPVGPTCDEYAQK Q9D0R2 6 1976.977 3.26 cytoplasmic C11(Carbamidomethyl); K17(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Threonine--tRNA ligase, QVMVVPVGPTCDEYAQK Q9D0R2 M3(Oxidation); C11(Carbamidomethyl); 1 2009.064 2.36 cytoplasmic K17(HeavyDimethyl) N-Term(Dimethyl); QVQDLELPSVEVDPCGDAQAAAEGAV Isoform 2 of Cytosol Q9CPY7-2 C15(Carbamidomethyl); K36(Dimethyl); 4 4218.061 4.24 LGLYEYDDLKQK aminopeptidase K38(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); QVQDLELPSVEVDPCGDAQAAAEGAV Isoform 2 of Cytosol C15(Carbamidomethyl); Q9CPY7-2 1 4242.177 4.14 LGLYEYDDLKQK aminopeptidase K36(HeavyDimethyl); K38(HeavyDimethyl) N-Term(Dimethyl); QVQDLELPSVEVDPCGDAQAAAEGAV Isoform 2 of Cytosol Q9CPY7-2 C15(Carbamidomethyl); K36(Dimethyl); 1 4374.234 3.49 LGLYEYDDLKQKK aminopeptidase K38(Dimethyl); K39(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C15(Carbamidomethyl); QVQDLELPSVEVDPCGDAQAAAEGAV Isoform 2 of Cytosol Q9CPY7-2 K36(HeavyDimethyl); 1 4406.405 3.41 LGLYEYDDLKQKK aminopeptidase K38(HeavyDimethyl); K39(HeavyDimethyl) N-Term(Dimethyl); QVQSLTCEVDALKGTNESLER P20152 Vimentin 1 2433.236 4.32 C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Long-chain-fatty-acid-- QVSDRAEYLGSCLLHK Q8JZR0 C12(Carbamidomethyl); 4 1948.084 3.20 CoA ligase 5 K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Ras-related protein Rap- C3(Carbamidomethyl); QWCNCAFLESSAK P62835 3 1672.839 2.28 1A C5(Carbamidomethyl); K13(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); Zinc finger and BTB C7(Carbamidomethyl); QYACELCGKPFKHPSNLELHK D6RGS0 domain-containing 1 2700.524 2.75 K9(HeavyDimethyl); protein 49 K12(HeavyDimethyl); K21(HeavyDimethyl) Ornithine N-Term(Dimethyl); QYFDFLSAYGAVSQGHCHPK P29758 aminotransferase, 14 2368.114 4.67 C17(Carbamidomethyl); K20(Dimethyl) mitochondrial Ornithine N-Term(Dimethyl:2H(6)13C(2)); QYFDFLSAYGAVSQGHCHPK P29758 aminotransferase, C17(Carbamidomethyl); 10 2384.202 4.57 mitochondrial K20(HeavyDimethyl) Carnitine O- N-Term(Dimethyl); QYGQTVATYESCSTAAFK P52825 palmitoyltransferase 2, 4 2067.962 5.48 C12(Carbamidomethyl); K18(Dimethyl) mitochondrial Carnitine O- N-Term(Dimethyl:2H(6)13C(2)); QYGQTVATYESCSTAAFK P52825 palmitoyltransferase 2, C12(Carbamidomethyl); 2 2084.050 5.88 mitochondrial K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isovaleryl-CoA K8(HeavyDimethyl); QYVYNVAKACDEGHIIPK Q9JHI5 dehydrogenase, 1 2213.272 2.62 C10(Carbamidomethyl); mitochondrial K18(HeavyDimethyl) N-Term(Dimethyl); C7(Carbamidomethyl); RAHSGECPYVCDQCGKR D3Z3V5 Zinc finger protein 689 1 2135.984 2.48 C11(Carbamidomethyl); C14(Carbamidomethyl); K16(Dimethyl) Cell division control RAIEIVESDVR E9PY34 1 1286.706 2.29 protein 6 homolog N-Term(Dimethyl:2H(6)13C(2)); Insulin-like growth RAPQTGIVDECCFR D3Z7M4 C11(Carbamidomethyl); 1 1744.861 2.20 factor I (Fragment) C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); RAQPPAASCMPLAEHEPMSPDSDAGC C9(Carbamidomethyl); M18(Oxidation); Q9WTW4 Transcription factor EC 1 4167.074 3.12 AGNPFTNLLALGK C26(Carbamidomethyl); K39(HeavyDimethyl) Isoform 2 of DNA- directed RNA RARQHLDDITAAR Q6P6I6-2 1 1522.829 2.44 polymerase II subunit GRINL1A RAVPRHQAHGANLR P30549 Substance-K receptor 2 1582.872 2.19 RAVSTCGSHLTMVGFLYGTIIWVYFQP N-Term(Dimethyl); Q8VGV7 Olfactory receptor 1 3816.844 2.85 PSQNSR C6(Carbamidomethyl); M12(Oxidation)

Serine/threonine-protein C2(Carbamidomethyl); RCPLSNNSEIALSLCRNK Q9Z265 1 2160.107 2.30 kinase Chk2 C15(Carbamidomethyl); K18(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); Zinc finger FYVE RCSKPVCDLISDMGNLVHATNSEEDIK K4(HeavyDimethyl); Q80U44 domain-containing 1 4155.236 2.91 QLLPDDPK C7(Carbamidomethyl); M13(Oxidation); protein 16 K27(HeavyDimethyl); K35(HeavyDimethyl)

RDDTFSVTMLGHCIEMYIGDSEAYIGA Cell division cycle N-Term(Dimethyl); M9(Oxidation); Q8R349 1 3479.652 2.90 DIK protein 16 homolog C13(Carbamidomethyl); K30(Dimethyl) M6(Oxidation); M14(Oxidation); RDFLQMVLDAQHSMNSVGVEGFDMV Thromboxane-A M24(Oxidation); P36423 1 4722.252 2.80 PESLSSSECTKEPPQR synthase C34(Carbamidomethyl); K36(HeavyDimethyl) Isoform 2 of NAD- RDGPGLGRSPGEPSAAVAPAAAGCEA Q923E4-2 dependent protein C24(Carbamidomethyl) 2 3486.747 3.07 ASAAAPAALWR deacetylase sirtuin-1 Sarcosine N-Term(Dimethyl); RDPLHEELLGQGCVFQER Q99LB7 dehydrogenase, 25 2211.092 5.64 C13(Carbamidomethyl) mitochondrial Sarcosine N-Term(Dimethyl:2H(6)13C(2)); RDPLHEELLGQGCVFQER Q99LB7 dehydrogenase, 20 2219.137 5.74 C13(Carbamidomethyl) mitochondrial Estradiol 17 beta- N-Term(Dimethyl:2H(6)13C(2)); REDIFYTSKVWCTFHRPELVR D3Z3P8 dehydrogenase 5 K9(HeavyDimethyl); 2 2811.522 3.34 (Fragment) C12(Carbamidomethyl) Isoform 2 of BMP-2- N-Term(Dimethyl); K7(Dimethyl); REITIMKELSGHK Q91Z96-2 1 1625.942 2.31 inducible protein kinase K13(Dimethyl) Mitochondrial fission REMVMYSITVAFWLLNSWLWFR F7BC60 1 2848.447 2.94 factor (Fragment) K7(Dimethyl); M17(Oxidation); RERTELKPDFFDPASIMDESVLGVSMF O35638 Cohesin subunit SA-2 1 3176.489 2.75 M26(Oxidation) tRNA (cytosine(34)- RFQQPPQPEGEEDASDGGR H3BKN0 N-Term(Dimethyl:2H(6)13C(2)) 1 2135.998 2.35 C(5))-methyltransferase Isoform N-Term(Dimethyl:2H(6)13C(2)); RFSMVIDNGIVKALNVEPDGTGLTCSL Cytoplasmic+peroxisom P99029-2 K12(HeavyDimethyl); 1 3815.119 3.66 APNILSQL al of Peroxiredoxin-5, C25(Carbamidomethyl) mitochondrial N-Term(Dimethyl); K4(Dimethyl); Carbonyl reductase RGDKILLNACCPGWVR P48758 C10(Carbamidomethyl); 2 1971.043 2.63 [NADPH] 1 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbonyl reductase K4(HeavyDimethyl); RGDKILLNACCPGWVR P48758 1 1987.133 2.73 [NADPH] 1 C10(Carbamidomethyl); C11(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); RGHIEDCGHWTQIEKPTEVNQILIK P34914-2 Bifunctional epoxide C7(Carbamidomethyl); K15(Dimethyl); 2 3085.612 3.48 hydrolase 2 K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Adenylate RGIHCAIDASQTPDIVFASILAAFSK Q9WTP6-2 C5(Carbamidomethyl); 1 2860.611 2.74 kinase 2, mitochondrial K26(HeavyDimethyl) Dihydropyrimidine N-Term(Dimethyl:2H(6)13C(2)); RGLPLAVKPVC Q8CHR6 dehydrogenase K8(HeavyDimethyl); 1 1281.863 2.47 [NADP(+)] C11(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl); RGLQGSFEELCR D3Z041 5 1479.736 2.60 CoA ligase 1 C11(Carbamidomethyl) Long-chain-fatty-acid-- N-Term(Dimethyl:2H(6)13C(2)); RGLQGSFEELCR D3Z041 1 1487.779 2.47 CoA ligase 1 C11(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); RGPCIIYNEDNGIIK Q9D8E6 8 1817.953 3.53 L4 C4(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein RGPCIIYNEDNGIIK Q9D8E6 C4(Carbamidomethyl); 7 1834.038 3.90 L4 K15(HeavyDimethyl) RHHGSFVPTSR E9PY53 Prostacyclin receptor 2 1280.669 2.26 N-Term(Dimethyl); M5(Oxidation); RHLFMMSLHSVTETAIAR Q5SVP0 Protein 9930111J21Rik1 1 2160.100 2.55 M6(Oxidation) Cadherin EGF LAG RHPDEPGQFAVALVVIYRTLGQLLPEH O35161 seven-pass G-type N-Term(Dimethyl) 1 3866.979 3.54 YDPDHR receptor 1 RHPDYSVSLLLR P07724 Serum albumin 3 1455.808 2.83 N-Term(Dimethyl:2H(6)13C(2)); C24(Carbamidomethyl); RHPYFYAPELLYYAEQYNEILTQCCAE C25(Carbamidomethyl); P07724 Serum albumin 2 4679.348 3.92 ADKESCLTPK K30(HeavyDimethyl); C33(Carbamidomethyl); K37(HeavyDimethyl) Isoform 4 of AT-rich N-Term(Dimethyl:2H(6)13C(2)); RITATMDDMLSTR A2BH40-4 interactive domain- 2 1562.820 2.69 M9(Oxidation) containing protein 1A N-Term(Dimethyl:2H(6)13C(2)); RIVVLCGQEAVK P20852 Cytochrome P450 2A5 C6(Carbamidomethyl); 1 1443.931 2.04 K12(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); RKAADAHVDAHYYEQNEQPTGTCAA Isoform Short of P55264-2 C23(Carbamidomethyl); 4 3617.647 4.96 CITGGNR Adenosine kinase C26(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); RKAADAHVDAHYYEQNEQPTGTCAA Isoform Short of K2(HeavyDimethyl); P55264-2 3 3633.730 4.88 CITGGNR Adenosine kinase C23(Carbamidomethyl); C26(Carbamidomethyl) K2(Dimethyl); C7(Carbamidomethyl); RKAFSTCSSHLCVVGLFFGIAMLVYM Q8VEV1 Olfactory receptor C12(Carbamidomethyl); 1 3851.883 3.14 VPDSDQR M22(Oxidation); M26(Oxidation) Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); RKMPGVPNGNVCHIEPEPHGGHSGPEL Q8JZR6-2 Electroneutral sodium K2(HeavyDimethyl); M3(Oxidation); 1 3275.627 2.93 ER bicarbonate exchanger 1 C12(Carbamidomethyl) N-Term(Dimethyl); RLCENIAGHLK P24270 Catalase 1 1366.754 2.61 C3(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); RLCENIAGHLKDAQLFIQK P24270 Catalase 2 2362.432 2.99 K11(HeavyDimethyl); K19(HeavyDimethyl) N-Term(Dimethyl); K4(Dimethyl); RLEKELGSPPGISLETIDAAFSCPGSSR Q91X72 Hemopexin 1 3030.557 2.81 C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); RLEMYSRNMVDYHLIMDLIPAISR Q8K224 N-acetyltransferase 10 1 2988.522 2.72 M9(Oxidation) 5'-AMP-activated N-Term(Dimethyl); RLFQQILSGVDYCHR Q5EG47 protein kinase catalytic 1 1920.018 2.28 C13(Carbamidomethyl) subunit alpha-1

N-Term(Dimethyl:2H(6)13C(2)); RLGEPEECAGLVSFLCSSDASYITGENI Dehydrogenase/reductas C8(Carbamidomethyl); Q149L0 1 4083.087 3.19 MVAGFSSKL e member 2 C16(Carbamidomethyl); M29(Oxidation); K36(HeavyDimethyl) RLLHLEGRTGTAEK Q8BV16 Protein Zfp398 K14(Dimethyl) 1 1608.919 2.26 RLMESYCETWRTETTGATGQASSLLS Isoform 3 of Collagen P39061-2 M3(Oxidation); C7(Carbamidomethyl) 2 3164.447 2.31 GR alpha-1(XVIII) chain M15(Oxidation); M19(Oxidation); RLSELGITQADDNIMSQEMFIEIMGNQ SHC SH2 domain- Q9Z179 M24(Oxidation); K29(Dimethyl); 1 3947.845 2.83 FKWNGK binding protein 1 K33(Dimethyl) RLSLPNTAWGSQSPEVASYGGGAAVG D3YWC9 MTSS1-like protein K46(HeavyDimethyl) 1 4830.421 3.68 LATEDEEQQLAANRHSLVEK Sodium channel and RLSQAEER F6WMQ9 clathrin linker 1 1 988.515 1.97 (Fragment) N-Term(Dimethyl); RLTPNCEITFIESEEGSGR F6V339 Glucokinase (Fragment) 1 2223.063 2.62 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); RLTPNCEITFIESEEGSGR P52792 Glucokinase 1 2231.119 2.35 C6(Carbamidomethyl) Retinol dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); RLWDVSCDLLGLPVDW Q9R1R8 2 1980.046 2.86 11 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K4(HeavyDimethyl); M7(Oxidation); C10(Carbamidomethyl); RLWKDGMAACCFVCSPCPENEISNET L7N2E1 Protein Vmn2r44 C11(Carbamidomethyl); 1 3743.733 2.58 NMDK C14(Carbamidomethyl); C17(Carbamidomethyl); K30(HeavyDimethyl)

N-Term(Dimethyl:2H(6)13C(2)); RMAEEGFLTEADMALIFVNWKELIMS Q9Z0R6 Intersectin-2 M13(Oxidation); K21(HeavyDimethyl); 1 3527.864 2.86 NTK M25(Oxidation); K29(HeavyDimethyl)

Isoform 2 of RMEGHNNEYRTEIK Q3UPP8-2 Centrosomal protein of M2(Oxidation); K14(Dimethyl) 1 1820.879 2.33 63 kDa Major facilitator RMFLTGSLLSSAGASLLMVLVPPVDR Q8R3N2 superfamily domain- M2(Oxidation); M18(Oxidation) 1 2762.483 2.23 containing protein 6-like Translation initiation RMTAAQPSETTVGNMVRR D3Z7J6 factor eIF-2B subunit N-Term(Dimethyl); M15(Oxidation) 1 2049.047 2.41 beta (Fragment) RMTMPEPELTTLGPELSELDTKLLLDL Q8VIM6 Stereocilin K22(Dimethyl); M32(Oxidation) 1 3953.078 3.18 PIQLMDR RNGLHDVDLNTFITEEMALHLDNGGT UPF0472 protein Q14AM7 K28(Dimethyl) 1 3194.584 2.90 RK C16orf72 homolog N-Term(Dimethyl); RPCFSALTVDETYVPK P07724 Serum albumin 9 1939.000 3.31 C3(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); RPCFSALTVDETYVPK P07724 Serum albumin C3(Carbamidomethyl); 1 1955.088 3.52 K16(HeavyDimethyl) N-Term(Dimethyl); RPCFSALTVDETYVPKEFK P07724 Serum albumin C3(Carbamidomethyl); K16(Dimethyl); 1 2371.244 3.03 K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); RPCFSALTVDETYVPKEFK P07724 Serum albumin 1 2395.369 2.84 K16(HeavyDimethyl); K19(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); RPGSVDVPLPESNIVRTIMEFLSFLHLK P47212 Galanin peptides 1 3282.913 3.22 M19(Oxidation); K28(HeavyDimethyl) DIP2 disco-interacting RPPLKEFFVDDSEEIVEVPQPDPNQPKP K5(Dimethyl); K27(Dimethyl); B2RQC7 protein 2 homolog B 1 4357.235 3.24 EGRQMTPVK K37(Dimethyl) (Drosophila) Uncharacterized protein RPPPWSLAAQVPPLPTLQGRSVSK Q6PIX9 N-Term(Dimethyl); K24(Dimethyl) 1 2638.512 2.79 C17orf80 homolog N-Term(Dimethyl:2H(6)13C(2)); High mobility group RPPSAFFLFCSEYRPK D3YZ18 C10(Carbamidomethyl); 1 2074.158 3.02 protein B1 (Fragment) K16(HeavyDimethyl) von Willebrand factor A C9(Carbamidomethyl); M12(Oxidation); RPSLLPQGCQLMRFFDQKPQAWGPVR A9Z1V5 domain-containing K18(HeavyDimethyl); 1 4053.053 2.81 ELDCGASR protein 5B1 C30(Carbamidomethyl) Cadherin-related family N-Term(Dimethyl:2H(6)13C(2)); RPSPAPHTVRIEWLKFR Q8VHP6 1 2162.305 2.20 member 1 K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); RPSRDPTGGLDQKSTSEDPK P70174 Histamine H1 receptor K13(HeavyDimethyl); 1 2279.263 2.33 K20(HeavyDimethyl) Down syndrome cell RPTVLEPTPMEASSSTSSTREGQQSWQ Q9ERC8 adhesion molecule K47(HeavyDimethyl) 1 4989.573 3.70 QGAVATLPQREGAELGQAAK homolog N-Term(Dimethyl:2H(6)13C(2)); RQCEEVAQALGKESLR Q9R0N0 Galactokinase C3(Carbamidomethyl); 1 1946.106 2.43 K12(HeavyDimethyl) RQHQHAHPPSGAPSTTPATGNGFPEK S4R2N4 Protein Sipa1l3 K26(Dimethyl) 1 2735.355 2.97 Angiopoietin-related RQIETLQQLVEVDGGIVSEVK Q9R045 N-Term(Dimethyl); K21(Dimethyl) 1 2396.360 2.99 protein 2 OTU domain-containing N-Term(Dimethyl:2H(6)13C(2)); RQLAGGPCVGGLPSYATFPR B2RUR8 1 2140.131 2.71 protein 7B C8(Carbamidomethyl) Tetratricopeptide repeat N-Term(Dimethyl); RQLVLLNPYAALCNR Q8VBW8 4 1829.025 3.02 protein 36 C13(Carbamidomethyl) Tetratricopeptide repeat N-Term(Dimethyl:2H(6)13C(2)); RQLVLLNPYAALCNR Q8VBW8 3 1837.070 3.60 protein 36 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); M7(Oxidation); K8(HeavyDimethyl); M10(Oxidation); RQLVVLMKTMDNVATFCMLLMLFIFI E0CXK2 Protein Cacna1i C17(Carbamidomethyl); 1 4694.503 3.23 FSILGMHIFGCK M18(Oxidation); C37(Carbamidomethyl); K38(HeavyDimethyl) HIRA-interacting RQNTSSRDDSNSTQEQAAAQGTTK Q8BLH7 K24(HeavyDimethyl) 1 2617.241 2.25 protein 3 RRPQQLTYNWTVLLNPR D6RCY7 P protein N-Term(Dimethyl) 2 2183.240 3.07 RRSEPSSSSSSSSPAAPVRPRPCPAVPAP Suppressor of cytokine N-Term(Dimethyl); O35716 1 3883.891 2.93 APGDTHFR signaling 1 C23(Carbamidomethyl) Zinc finger and BTB RSHTGRQPSDSLTPALWGEAIHL D6RGS0 domain-containing 2 2529.264 2.57 protein 49 Isoform 2 of Neuroepithelial cell- N-Term(Dimethyl); M9(Oxidation); RSSALWSEMLDINMK Q9Z206-2 2 1852.940 2.32 transforming gene 1 K15(Dimethyl) protein RSSLASPFPPGTPPENGASSLPGLTPAQ P47806 Zinc finger protein GLI1 M31(Oxidation) 2 3449.714 3.17 HYMLR Alpha-aminoadipic N-Term(Dimethyl); RSTCTINYSTSLPLAQGIK G3UYR8 semialdehyde 4 2166.155 4.41 C4(Carbamidomethyl); K19(Dimethyl) dehydrogenase F-box/LRR-repeat N-Term(Dimethyl); M12(Oxidation); RSTITDAGLEVMLEQMQGVVR A2RT62 1 2393.191 2.35 protein 16 M16(Oxidation) RTETDFSNLFAQDLLPAKNGEEQTAQF Glutamate N-Term(Dimethyl:2H(6)13C(2)); D3Z1L8 1 4682.478 3.23 LLEVVDILLNYVR decarboxylase 1 K18(HeavyDimethyl) Isoform Short of N-Term(Dimethyl); RTGCTFPEKPDFH P55264-2 1 1647.787 2.23 Adenosine kinase C4(Carbamidomethyl); K9(Dimethyl) Ester hydrolase N-Term(Dimethyl); RTGELNFVSCMR Q91V76 1 1497.726 2.45 C11orf54 homolog C10(Carbamidomethyl) Ester hydrolase N-Term(Dimethyl:2H(6)13C(2)); RTGELNFVSCMR Q91V76 1 1505.767 2.73 C11orf54 homolog C10(Carbamidomethyl) N-Term(Dimethyl); RTIQFVDWCPTGFK P05214 Tubulin alpha-3 chain 1 1810.932 2.62 C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); RTIQFVDWCPTGFK P05214 Tubulin alpha-3 chain C9(Carbamidomethyl); 1 1827.021 2.44 K14(HeavyDimethyl) Sarcosine N-Term(Dimethyl); RVAAVETEHGSIQTPCVVNCAGVWAS Q99LB7 dehydrogenase, C16(Carbamidomethyl); 5 2982.478 4.65 K mitochondrial C20(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sarcosine RVAAVETEHGSIQTPCVVNCAGVWAS C16(Carbamidomethyl); Q99LB7 dehydrogenase, 4 2998.572 6.18 K C20(Carbamidomethyl); mitochondrial K27(HeavyDimethyl) Sarcosine N-Term(Dimethyl); RVAAVETEHGSIQTPCVVNCAGVWAS Q99LB7 dehydrogenase, C16(Carbamidomethyl); 9 3294.670 4.52 KVGR mitochondrial C20(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sarcosine RVAAVETEHGSIQTPCVVNCAGVWAS C16(Carbamidomethyl); Q99LB7 dehydrogenase, 3 3310.776 4.76 KVGR C20(Carbamidomethyl); mitochondrial K27(HeavyDimethyl) RVGQAVLDTLEGALSAGDMATAPTHY Tubulin polyglutamylase Q99MS8 M19(Oxidation) 2 3273.644 2.94 LEAGSR complex subunit 1 RVLTVAYGEPVHHVMQFDPMDPGYL M20(Oxidation); M28(Oxidation); Q3UH93 Plexin-D1 1 4393.146 2.84 YLMTSHQMARVK M33(Oxidation); K37(Dimethyl) Cytochrome P450 N-Term(Dimethyl:2H(6)13C(2)); RVQQEIDEVIGQVQCPEMADQAR Q9JKY7 1 2735.354 2.67 CYP2D22 C15(Carbamidomethyl) RVSAASVALLNTSKNGISVTGGITEEQF Enhancer of polycomb Q8C0I4 K14(Dimethyl) 1 4383.315 3.21 QTHQQQLVQMQR homolog 2 RVTVYLPLATNSPR Q60841-3 Isoform 3 of Reelin 1 1586.880 2.14 N-Term(Dimethyl); RWLLLCNPGLADLIAEK Q3UEJ6 Phosphorylase 5 2038.157 4.41 C6(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); RWLLLCNPGLADLIAEK Q3UEJ6 Phosphorylase C6(Carbamidomethyl); 4 2054.246 3.70 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phosphoglycerate RYADLTEDQLPSCESLKDTIAR Q9DBJ1 C13(Carbamidomethyl); 1 2653.405 2.78 mutase 1 K17(HeavyDimethyl) Coiled-coil-helix-coiled- coil-helix domain- N-Term(Dimethyl); RYEYHPVCADLQTK F6QFL0 containing protein 3, 3 1835.904 2.83 C8(Carbamidomethyl); K14(Dimethyl) mitochondrial (Fragment) Coiled-coil-helix-coiled- coil-helix domain- N-Term(Dimethyl:2H(6)13C(2)); RYEYHPVCADLQTK F6QFL0 containing protein 3, C8(Carbamidomethyl); 1 1851.997 2.46 mitochondrial K14(HeavyDimethyl) (Fragment) RYGRFMLLDNVGSPGPSSEAAAAGSPT Meiotic recombination Q9CWH4 M6(Oxidation); K29(HeavyDimethyl) 1 3074.589 2.87 WK protein REC114-like M3(Oxidation); M7(Oxidation); RYMAPEMLDDTMNLSIFESFK A2AJR6 Activin receptor type-1C 1 2606.229 2.71 K21(HeavyDimethyl) C4(Carbamidomethyl); RYWCQECGK Q499D5 Protein Zfp235 2 1314.556 2.09 C7(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SAALLLQNDHNADVQSKMMVNR Q8C8R3-8 Isoform 8 of Ankyrin-2 1 2543.356 2.63 K17(HeavyDimethyl); M18(Oxidation) Phosphatidate K8(HeavyDimethyl); SADRLTPKNNLEMLWLWGELPQAAK E9QKQ5 1 2953.631 2.26 phosphatase LPIN1 K25(HeavyDimethyl) Delta-1-pyrroline-5- N-Term(Dimethyl); K9(Dimethyl); carboxylate SAFEYGGQKCSACSR Q8CHT0 C10(Carbamidomethyl); 4 1763.779 4.19 dehydrogenase, C13(Carbamidomethyl) mitochondrial Delta-1-pyrroline-5- N-Term(Dimethyl:2H(6)13C(2)); carboxylate K9(HeavyDimethyl); SAFEYGGQKCSACSR Q8CHT0 2 1779.868 4.81 dehydrogenase, C10(Carbamidomethyl); mitochondrial C13(Carbamidomethyl) SAFTRVASMASFQPTETPDLEKSLAEM Sperm-associated N-Term(Dimethyl); M9(Oxidation); Q7TME2 1 3943.005 3.30 STVLQELK antigen 5 K22(Dimethyl); K35(Dimethyl) Isoform 2 of Cytosol N-Term(Dimethyl); SAGACTAAAFLR Q9CPY7-2 7 1223.617 2.93 aminopeptidase C5(Carbamidomethyl) Isoform 2 of Cytosol N-Term(Dimethyl:2H(6)13C(2)); SAGACTAAAFLR Q9CPY7-2 6 1231.661 3.08 aminopeptidase C5(Carbamidomethyl) Isoform 2 of Cytosol N-Term(Dimethyl); SAGACTAAAFLREFVTHTK Q9CPY7-2 2 2094.084 3.11 aminopeptidase C5(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Cytosol SAGACTAAAFLREFVTHTK Q9CPY7-2 C5(Carbamidomethyl); 1 2110.165 2.91 aminopeptidase K19(HeavyDimethyl) Undifferentiated SAGDVPVTTSDAFATSGGMAEPGSPK Q6J1H4 embryonic cell M19(Oxidation); K26(Dimethyl) 1 3489.661 2.88 APVSPDSAQR transcription factor 1 Leucine-rich PPR motif- N-Term(Dimethyl); K9(Dimethyl); SAGEDVTEKTLLSNCK Q6PB66 containing protein, 1 1835.934 2.29 C15(Carbamidomethyl); K16(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Leucine-rich PPR motif- K9(HeavyDimethyl); SAGEDVTEKTLLSNCK Q6PB66 containing protein, 3 1860.069 2.61 C15(Carbamidomethyl); mitochondrial K16(HeavyDimethyl) SAGQGEVLVYVEDPAGHQEEAK F6XC15 Filamin-A (Fragment) K22(HeavyDimethyl) 1 2349.198 2.45 SAGVDDQENWHEGKENIRAAVAAGC Isoform 2 of Cytosol N-Term(Dimethyl); K14(Dimethyl); Q9CPY7-2 3 2896.363 3.90 R aminopeptidase C25(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SAGVDDQENWHEGKENIRAAVAAGC Isoform 2 of Cytosol Q9CPY7-2 K14(HeavyDimethyl); 3 2912.458 3.15 R aminopeptidase C25(Carbamidomethyl) C13(Carbamidomethyl); SAGWVIPIGLLFCK Q921I1 Serotransferrin 1 1596.951 2.02 K14(HeavyDimethyl) N-Term(Dimethyl); SAGWVIPIGLLFCK Q921I1 Serotransferrin 17 1616.926 4.63 C13(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SAGWVIPIGLLFCK Q921I1 Serotransferrin C13(Carbamidomethyl); 19 1633.022 4.48 K14(HeavyDimethyl) SALEGQDSNPSSSNSSQDSLHKGAKR B8QI36 Liprin-alpha 4 K22(Dimethyl); K25(Dimethyl) 1 2743.332 3.50 C9(Carbamidomethyl); SALEHSVQCAVDVK P24270 Catalase 2 1578.833 2.43 K14(HeavyDimethyl) N-Term(Dimethyl); SALEHSVQCAVDVK P24270 Catalase 17 1598.815 4.31 C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SALEHSVQCAVDVK P24270 Catalase C9(Carbamidomethyl); 10 1614.904 3.97 K14(HeavyDimethyl) C9(Carbamidomethyl); SALEHSVQCAVDVKR P24270 Catalase 1 1734.928 2.85 K14(HeavyDimethyl) N-Term(Dimethyl); SALEHSVQCAVDVKR P24270 Catalase 22 1754.915 4.86 C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SALEHSVQCAVDVKR P24270 Catalase C9(Carbamidomethyl); 15 1771.006 4.48 K14(HeavyDimethyl) SALEHSVQCAVDVKRFNSANEDNVTQ N-Term(Dimethyl); P24270 Catalase 5 3229.600 4.77 VR C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SALEHSVQCAVDVKRFNSANEDNVTQ P24270 Catalase C9(Carbamidomethyl); 4 3245.690 5.18 VR K14(HeavyDimethyl) Isoform 2 of Phospholysine SALQAIGVEAHQAIMIGDDIVGDVGGA N-Term(Dimethyl); Q9D7I5-2 phosphohistidine 1 3395.665 2.83 QQCGMR C30(Carbamidomethyl) inorganic pyrophosphate phosphatase

SANPRDHPVIHPNYLSTETDVEDFRQC Choline dehydrogenase, N-Term(Dimethyl); Q8BJ64 1 3480.667 3.58 VR mitochondrial C27(Carbamidomethyl)

4- N-Term(Dimethyl); SAPALACGNAMIFKPSPFTPVSALLLAE Q9JLJ2 trimethylaminobutyralde C7(Carbamidomethyl); K14(Dimethyl); 5 3462.897 5.13 IYTK hyde dehydrogenase K32(Dimethyl)

4- N-Term(Dimethyl); SAPALACGNAMIFKPSPFTPVSALLLAE Q9JLJ2 trimethylaminobutyralde C7(Carbamidomethyl); M11(Oxidation); 1 3478.875 3.91 IYTK hyde dehydrogenase K14(Dimethyl); K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- SAPALACGNAMIFKPSPFTPVSALLLAE C7(Carbamidomethyl); Q9JLJ2 trimethylaminobutyralde 3 3487.005 6.58 IYTK K14(HeavyDimethyl); hyde dehydrogenase K32(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- SAPALACGNAMIFKPSPFTPVSALLLAE C7(Carbamidomethyl); M11(Oxidation); Q9JLJ2 trimethylaminobutyralde 1 3503.019 5.02 IYTK K14(HeavyDimethyl); hyde dehydrogenase K32(HeavyDimethyl)

Malate dehydrogenase, K7(HeavyDimethyl); SAPSIPKENFSCLTR P14152 1 1742.925 2.06 cytoplasmic C12(Carbamidomethyl)

Malate dehydrogenase, N-Term(Dimethyl); K7(Dimethyl); SAPSIPKENFSCLTR P14152 1 1762.913 2.40 cytoplasmic C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, SAPSIPKENFSCLTR P14152 K7(HeavyDimethyl); 13 1778.998 3.64 cytoplasmic C12(Carbamidomethyl) Malate dehydrogenase, N-Term(Dimethyl); K7(Dimethyl); SAPSIPKENFSCLTRLDHNR P14152 1 2398.234 3.01 cytoplasmic C12(Carbamidomethyl)

Protein transport protein N-Term(Dimethyl); SAQLQHAVQSQGFIGYCQK S4R2A9 1 2206.106 4.13 Sec31A (Fragment) C17(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein transport protein SAQLQHAVQSQGFIGYCQK S4R2A9 C17(Carbamidomethyl); 1 2222.192 2.79 Sec31A (Fragment) K19(HeavyDimethyl) Calcium-activated SARLQIPGTAETGTWTYSITGTK Q9EQR4 chloride channel K23(Dimethyl) 2 2467.282 2.29 regulator 2

Microtubule associated SASATALSLLIPSEHHACSPLASPMSPH B1AST8 serine/threonine kinase C18(Carbamidomethyl); M25(Oxidation) 1 3815.817 2.76 SQSSNPSSR 2, isoform CRA_b

SASGQLGAANSGHPLQSSGYKMTTED N-Term(Dimethyl); K21(Dimethyl); A2BI37 Zinc finger protein 185 1 2969.416 2.28 YK K28(Dimethyl) 6-phosphogluconate N-Term(Dimethyl); SAVDNCQDSWR Q9DCD0 dehydrogenase, 1 1365.581 2.51 C6(Carbamidomethyl) decarboxylating N-Term(Dimethyl:2H(6)13C(2)); SAVEQLCLAESARPR E9Q6H8 Protein Plekha5 1 1722.944 2.24 C7(Carbamidomethyl) Trifunctional enzyme N-Term(Dimethyl); K8(Dimethyl); SAVLISSKPGCFVAGADINMLSSCTTPQ Q8BMS1 subunit alpha, C11(Carbamidomethyl); 4 3424.691 4.83 EATR mitochondrial C24(Carbamidomethyl) Trifunctional enzyme N-Term(Dimethyl); K8(Dimethyl); SAVLISSKPGCFVAGADINMLSSCTTPQ Q8BMS1 subunit alpha, C11(Carbamidomethyl); 2 3440.697 3.57 EATR mitochondrial M20(Oxidation); C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme SAVLISSKPGCFVAGADINMLSSCTTPQ K8(HeavyDimethyl); Q8BMS1 subunit alpha, 1 3440.786 3.87 EATR C11(Carbamidomethyl); mitochondrial C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme SAVLISSKPGCFVAGADINMLSSCTTPQ K8(HeavyDimethyl); Q8BMS1 subunit alpha, 1 3456.772 2.82 EATR C11(Carbamidomethyl); mitochondrial M20(Oxidation); C24(Carbamidomethyl) Trifunctional enzyme N-Term(Dimethyl); K8(Dimethyl); SAVLISSKPGCFVAGADINMLSSCTTPQ Q8BMS1 subunit alpha, C11(Carbamidomethyl); 1 4223.108 4.19 EATRISQEGQR mitochondrial C24(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme SAVLISSKPGCFVAGADINMLSSCTTPQ K8(HeavyDimethyl); Q8BMS1 subunit alpha, 1 4239.190 3.89 EATRISQEGQR C11(Carbamidomethyl); mitochondrial C24(Carbamidomethyl) Carbamoyl-phosphate N-Term(Dimethyl); SAYALGGLGSGICPNK Q8C196 synthase [ammonia], 7 1620.836 4.00 C13(Carbamidomethyl); K16(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); SAYALGGLGSGICPNK Q8C196 synthase [ammonia], C13(Carbamidomethyl); 5 1636.929 3.38 mitochondrial K16(HeavyDimethyl) Carbamoyl-phosphate C13(Carbamidomethyl); K16(Dimethyl); SAYALGGLGSGICPNKETLIDLGTK Q8C196 synthase [ammonia], 1 2591.378 3.22 K25(Dimethyl) mitochondrial Carbamoyl-phosphate C13(Carbamidomethyl); SAYALGGLGSGICPNKETLIDLGTK Q8C196 synthase [ammonia], K16(HeavyDimethyl); 1 2607.474 2.41 mitochondrial K25(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); SAYALGGLGSGICPNKETLIDLGTK Q8C196 synthase [ammonia], C13(Carbamidomethyl); K16(Dimethyl); 17 2619.408 5.47 mitochondrial K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate C13(Carbamidomethyl); SAYALGGLGSGICPNKETLIDLGTK Q8C196 synthase [ammonia], 15 2643.534 5.85 K16(HeavyDimethyl); mitochondrial K25(HeavyDimethyl) Carbamoyl-phosphate C13(Carbamidomethyl); SAYALGGLGSGICPNKETLIDLGTKAF Q8C196 synthase [ammonia], K16(HeavyDimethyl); 1 3981.135 3.21 AMTNQILVER mitochondrial K25(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); SAYALGGLGSGICPNKETLIDLGTKAF Q8C196 synthase [ammonia], C13(Carbamidomethyl); K16(Dimethyl); 7 3993.139 6.53 AMTNQILVER mitochondrial K25(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl); SAYALGGLGSGICPNKETLIDLGTKAF Q8C196 synthase [ammonia], C13(Carbamidomethyl); K16(Dimethyl); 6 4009.122 4.55 AMTNQILVER mitochondrial K25(Dimethyl); M29(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate SAYALGGLGSGICPNKETLIDLGTKAF C13(Carbamidomethyl); Q8C196 synthase [ammonia], 8 4017.260 7.21 AMTNQILVER K16(HeavyDimethyl); mitochondrial K25(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate SAYALGGLGSGICPNKETLIDLGTKAF C13(Carbamidomethyl); Q8C196 synthase [ammonia], 3 4033.261 4.48 AMTNQILVER K16(HeavyDimethyl); mitochondrial K25(HeavyDimethyl); M29(Oxidation) N-Term(Dimethyl); SAYDALPSTTVVSMACCASGSTR F8VPN4 Protein Agl C16(Carbamidomethyl); 4 2420.087 5.21 C17(Carbamidomethyl) N-Term(Dimethyl); M14(Oxidation); SAYDALPSTTVVSMACCASGSTR F8VPN4 Protein Agl C16(Carbamidomethyl); 2 2436.082 3.45 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SAYDALPSTTVVSMACCASGSTR F8VPN4 Protein Agl C16(Carbamidomethyl); 5 2428.133 5.51 C17(Carbamidomethyl) ATP synthase subunit d, N-Term(Dimethyl); SCAEFVSGSQLR B1ASE2 mitochondrial 3 1368.652 3.07 C2(Carbamidomethyl) (Fragment)

ATP synthase subunit d, N-Term(Dimethyl:2H(6)13C(2)); SCAEFVSGSQLR B1ASE2 mitochondrial 1 1376.695 2.21 C2(Carbamidomethyl) (Fragment) Cytosolic 10- N-Term(Dimethyl); SCALSNVK Q8R0Y6 formyltetrahydrofolate 2 934.502 2.28 C2(Carbamidomethyl); K8(Dimethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); SCALSNVK Q8R0Y6 formyltetrahydrofolate C2(Carbamidomethyl); 2 950.587 2.13 dehydrogenase K8(HeavyDimethyl) N-Term(Dimethyl); SCEAGYSPSYKEDKHFGYTSYSVSNSV P10605 Cathepsin B C2(Carbamidomethyl); K11(Dimethyl); 2 3289.542 3.82 K K14(Dimethyl); K28(Dimethyl)

N-Term(Dimethyl); Vitamin D-binding C2(Carbamidomethyl); SCESDAPFPVHPGTPECCTKEGLER P21614 5 2916.284 3.66 protein C17(Carbamidomethyl); C18(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); Vitamin D-binding SCESDAPFPVHPGTPECCTKEGLER P21614 C17(Carbamidomethyl); 7 2932.378 4.59 protein C18(Carbamidomethyl); K20(HeavyDimethyl) Eukaryotic translation N-Term(Dimethyl); SCGSSTPDEFPSDIPGTK Q9Z0N2 initiation factor 2 1 1937.885 2.39 C2(Carbamidomethyl); K18(Dimethyl) subunit 3, Y-linked N-Term(Dimethyl); DNA replication SCHNTLTNIAMPRPRGLCLPR P49718 C2(Carbamidomethyl); 1 2492.259 2.82 licensing factor MCM5 C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SCMVATLQIIQSDIPELLSLNLTNNKLY C2(Carbamidomethyl); M3(Oxidation); Q8R499 NXF2 1 4533.418 2.89 QLDGLSDMTEK K26(HeavyDimethyl); K39(HeavyDimethyl) Voltage-dependent anion- N-Term(Dimethyl); SCSGVEFSTSGHAYTDTGK Q60931 selective channel protein 2 2046.906 3.60 C2(Carbamidomethyl); K19(Dimethyl) 3 Voltage-dependent anion- N-Term(Dimethyl); SCSGVEFSTSGSSNTDTGK D3YUN8 selective channel protein 2 1963.848 3.30 C2(Carbamidomethyl); K19(Dimethyl) 2 (Fragment)

Voltage-dependent anion-N-Term(Dimethyl:2H(6)13C(2)); SCSGVEFSTSGSSNTDTGK D3YUN8 selective channel protein C2(Carbamidomethyl); 3 1979.947 3.66 2 (Fragment) K19(HeavyDimethyl)

Peptidyl-prolyl cis-trans N-Term(Dimethyl); SCSQVLEHQPDNIK O35465 1 1710.845 2.56 isomerase FKBP8 C2(Carbamidomethyl); K14(Dimethyl) N-acyl-aromatic-L- amino acid N-Term(Dimethyl); SCTLTFLGSTATPDDPYEVKR Q91XE4 1 2414.192 3.36 amidohydrolase C2(Carbamidomethyl); K20(Dimethyl) (carboxylate-forming) Persulfide dioxygenase N-Term(Dimethyl); SCTYTYLLGDRESR Q9DCM0 3 1748.823 2.67 ETHE1, mitochondrial C2(Carbamidomethyl) PCTP-like protein N-Term(Dimethyl); SCVITYLAQVDPK G3UY87 5 1549.822 4.20 (Fragment) C2(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); PCTP-like protein SCVITYLAQVDPK G3V020 C2(Carbamidomethyl); 3 1565.920 2.96 (Fragment) K13(HeavyDimethyl) N-Term(Dimethyl); PCTP-like protein SCVITYLAQVDPKGSLPK G3UY87 C2(Carbamidomethyl); K13(Dimethyl); 1 2060.149 2.63 (Fragment) K18(Dimethyl) O-acetyl-ADP-ribose N-Term(Dimethyl); SCYLSSLDLLLEHR Q922B1 1 1733.892 2.43 deacetylase MACROD1 C2(Carbamidomethyl)

O-acetyl-ADP-ribose N-Term(Dimethyl:2H(6)13C(2)); SCYLSSLDLLLEHR Q922B1 2 1741.940 3.17 deacetylase MACROD1 C2(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein Cfhr2 SDDEIRYECNYGFYPVTGSTVSK Q4LDF6 C9(Carbamidomethyl); 3 2759.325 3.91 (Precursor) K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SDDHVVSGTLVTPLPAVLGHEGAGIVE Alcohol dehydrogenase C35(Carbamidomethyl); P00329 1 4191.323 3.20 SVGEGVTCVKPGDK 1 K37(HeavyDimethyl); K41(HeavyDimethyl) UDP- N-Term(Dimethyl); K5(Dimethyl); SDFVKDYPRPIMPNMVFIGGINCLQK Q63886 glucuronosyltransferase 4 3123.621 3.73 C23(Carbamidomethyl); K26(Dimethyl) 1-1 N-Term(Dimethyl:2H(6)13C(2)); UDP- K5(HeavyDimethyl); SDFVKDYPRPIMPNMVFIGGINCLQK Q63886 glucuronosyltransferase 2 3147.746 3.07 C23(Carbamidomethyl); 1-1 K26(HeavyDimethyl) Transmembrane and C8(Carbamidomethyl); K15(Dimethyl); SDNGTYSCIASSSLKMETMDFHLLVK Q9D7L8 immunoglobulin domain- 1 2990.453 2.83 K26(Dimethyl) containing protein 1 SDTLATATALHGYGGMNLTMNLTAP Zinc finger protein ZIC N-Term(Dimethyl); M35(Oxidation); G3UXS7 1 4379.214 3.05 HGPGAFFRYMRQPIK 4 (Fragment) K40(Dimethyl) Isoform 2 of Clustered N-Term(Dimethyl); SEDSIGPEAGCEEEGSSVSGLAK Q5SW19-2 mitochondria protein 3 2351.054 5.38 C11(Carbamidomethyl); K23(Dimethyl) homolog Isoform 2 of Clustered N-Term(Dimethyl:2H(6)13C(2)); SEDSIGPEAGCEEEGSSVSGLAK Q5SW19-2 mitochondria protein C11(Carbamidomethyl); 3 2367.143 4.94 homolog K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase SEGGFIWACK O88844 C9(Carbamidomethyl); 1 1226.671 2.09 [NADP] cytoplasmic K10(HeavyDimethyl) Protein-glutamine N-Term(Dimethyl); SEGTYCCGPVSVR P21981 gamma- C6(Carbamidomethyl); 4 1499.663 3.37 glutamyltransferase 2 C7(Carbamidomethyl) Protein-glutamine N-Term(Dimethyl:2H(6)13C(2)); SEGTYCCGPVSVR P21981 gamma- C6(Carbamidomethyl); 2 1507.703 3.35 glutamyltransferase 2 C7(Carbamidomethyl) Transmembrane protein N-Term(Dimethyl:2H(6)13C(2)); SEIPNNPGSSDTTPLMTEPVINR Q8VEH0 1 2521.238 2.55 144 M16(Oxidation) Unconventional myosin- SESIDVTLNVEQAAYTR G3V011 1 1895.918 2.16 If K13(HeavyDimethyl); SEVDGLLDLARQKFSCLMEEQCFLNV Dehydrodolichyl C16(Carbamidomethyl); A3KGL2 1 4022.891 2.93 CFAYTSR diphosphate synthase C22(Carbamidomethyl); C27(Carbamidomethyl) Isoform 2 of Protein SEVILFIMSKVPLPSVHHPVETGR Q6ZQ18-2 K10(Dimethyl) 1 2700.527 2.64 EFR3 homolog B N-Term(Dimethyl); SFCERFPEDGPELEEVLIQLAAADAR Q99KK7 Dipeptidyl peptidase 3 1 2990.467 2.87 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SFCERFPEDGPELEEVLIQLAAADAR Q99KK7 Dipeptidyl peptidase 3 1 2998.496 3.14 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C10(Carbamidomethyl); SFDDSGSGYCRSEAVVAVLLTKK P19096 Fatty acid synthase 1 2597.469 2.58 K22(HeavyDimethyl); K23(HeavyDimethyl) Unconventional myosin- N-Term(Dimethyl); K7(Dimethyl); SFDNRVKAIEECK Q8C170 1 1679.855 2.70 IXa C12(Carbamidomethyl); K13(Dimethyl)

K6(HeavyDimethyl); SFELEKEADDMEIEINSLNKMAR Q9CTN5 Protein SIX 1 2800.396 2.69 K20(HeavyDimethyl); M21(Oxidation) SFHNQFHTCRVQGAWPLLDNDFLFVQ Q7TQ32 Hemojuvelin C9(Carbamidomethyl) 1 4677.248 2.64 ATSSPVSSGANATTIR SFLTQPVTLLDIYTHWQQTSELGQKQK K25(Dimethyl); K27(Dimethyl); O08784 Treacle protein 1 4374.262 2.98 AEDDETLQAK K37(Dimethyl) Acyl-coenzyme A K13(HeavyDimethyl); SFLVGSAAQSLSKACTIAIRYSAVR A2A848 1 2692.475 2.50 oxidase (Fragment) C15(Carbamidomethyl) N-Term(Dimethyl); SFSIASDPTSASSCYLEEHVSK P00186 Cytochrome P450 1A2 4 2458.143 4.80 C14(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SFSIASDPTSASSCYLEEHVSK P00186 Cytochrome P450 1A2 C14(Carbamidomethyl); 2 2474.235 4.88 K22(HeavyDimethyl) Isoform 2 of Zinc finger SFSLSANFNNTPEEAPSGAKTHR Q8BGS3-2 protein with KRAB and N-Term(Dimethyl); K20(Dimethyl) 1 2518.247 2.61 SCAN domains 1 SFSQSSSLSRHKR Q9CZP3 Protein Zfp655 N-Term(Dimethyl); K12(Dimethyl) 5 1562.824 2.75 SFSQSTTLKTHQR Q6PEP4 Protein Zfp677 K9(Dimethyl) 1 1548.807 2.39 Acylpyruvase FAHD1, N-Term(Dimethyl); SFTSSCPVSAFVPK Q8R0F8 8 1569.797 3.96 mitochondrial C6(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Acylpyruvase FAHD1, SFTSSCPVSAFVPK Q8R0F8 C6(Carbamidomethyl); 1 1585.877 3.18 mitochondrial K14(HeavyDimethyl) N-Term(Dimethyl); ATP-binding cassette SGANVLICGPNGCGK P55096 C8(Carbamidomethyl); 2 1559.764 3.10 sub-family D member 3 C13(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); ATP-binding cassette C8(Carbamidomethyl); SGANVLICGPNGCGK P55096 3 1575.849 2.87 sub-family D member 3 C13(Carbamidomethyl); K15(HeavyDimethyl) N-Term(Dimethyl); SGCTINNPAEFIVDPK Q80X90 Filamin-B 1 1817.921 2.47 C3(Carbamidomethyl); K16(Dimethyl) SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- N-Term(Dimethyl); K13(Dimethyl); P10126 23 3051.463 5.17 GR alpha 1 C16(Carbamidomethyl) SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- N-Term(Dimethyl); M9(Oxidation); P10126 8 3067.435 4.87 GR alpha 1 K13(Dimethyl); C16(Carbamidomethyl) N-Term(Dimethyl); M9(Oxidation); SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- P10126 K13(Dimethyl); M15(Oxidation); 4 3083.451 4.85 GR alpha 1 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- P10126 K13(HeavyDimethyl); 21 3067.552 5.46 GR alpha 1 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- P10126 K13(HeavyDimethyl); M15(Oxidation); 11 3083.547 4.39 GR alpha 1 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- P10126 M9(Oxidation); K13(HeavyDimethyl); 11 3083.542 4.40 GR alpha 1 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SGDAAIVDMVPGKPMCVESFSDYPPL Elongation factor 1- P10126 M9(Oxidation); K13(HeavyDimethyl); 3 3099.538 4.10 GR alpha 1 M15(Oxidation); C16(Carbamidomethyl) Isoform 2 of Protein SGDGGSSGSGARSGDGGSSR Q4VAA2-2 1 1697.729 2.27 CDV3 Isoform 2 of 2- oxoisovalerate N-Term(Dimethyl); SGDLFNCGSLTIR Q6P3A8-2 1 1467.721 2.39 dehydrogenase subunit C7(Carbamidomethyl) beta, mitochondrial

Isoform 2 of 2- oxoisovalerate N-Term(Dimethyl:2H(6)13C(2)); SGDLFNCGSLTIR Q6P3A8-2 2 1475.773 2.66 dehydrogenase subunit C7(Carbamidomethyl) beta, mitochondrial Isoform 2 of Protein SGDTGTHEAMAPIIVVAPGNR Q3UH53-2 2 2093.039 2.43 sidekick-1 N-Term(Dimethyl); SGECPAALVGGINLLLKPNTSVQFMK P19096 Fatty acid synthase C4(Carbamidomethyl); K17(Dimethyl); 2 2828.538 3.20 K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); SGECPAALVGGINLLLKPNTSVQFMK P19096 Fatty acid synthase 3 2852.666 3.37 K17(HeavyDimethyl); K26(HeavyDimethyl) SGEGFLCVFSITEMESFAATADFREQIL Ras-related protein Ral- P63321 C7(Carbamidomethyl); K31(Dimethyl) 1 3566.774 2.79 RVK A N-Term(Dimethyl); SGETEDTFIADLVVGLCTGQIK Q6PHC1 Alpha-enolase 10 2409.220 5.07 C17(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SGETEDTFIADLVVGLCTGQIK Q6PHC1 Alpha-enolase C17(Carbamidomethyl); 7 2425.320 5.51 K22(HeavyDimethyl) N-Term(Dimethyl); SGETEDTFIADLVVGLCTGQIKTGAPC Q6PHC1 Alpha-enolase C17(Carbamidomethyl); K22(Dimethyl); 1 3423.698 3.61 RSER C27(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SGETEDTFIADLVVGLCTGQIKTGAPC C17(Carbamidomethyl); Q6PHC1 Alpha-enolase 1 3439.795 3.42 RSER K22(HeavyDimethyl); C27(Carbamidomethyl) Acyl-CoA synthetase N-Term(Dimethyl); K11(Dimethyl); SGETTTAEEIKAFCK Q8VCW8 family member 2, 3 1755.878 4.54 C14(Carbamidomethyl); K15(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Acyl-CoA synthetase K11(HeavyDimethyl); SGETTTAEEIKAFCK Q8VCW8 family member 2, 4 1780.008 4.08 C14(Carbamidomethyl); mitochondrial K15(HeavyDimethyl) SGGAATVEEAPSDVEAAAARRVDDLL PDZ domain-containing Q8R5M0 M30(Oxidation) 1 3422.657 2.66 ESYMGIR protein GIPC3 N-Term(Dimethyl:2H(6)13C(2)); SGGSKDNLSPPLGQCLTER H7BX99 Prothrombin K5(HeavyDimethyl); 1 2088.136 2.76 C15(Carbamidomethyl) SGGWHGPSLCVVLVFLLWWLPATGLY Isoform 2 of Alpha-(1,3)- N-Term(Dimethyl); Q5F2L2-2 1 3043.582 2.45 S fucosyltransferase 10 C10(Carbamidomethyl) Isoform 3 of Sodium- SGLELTELQNMTVPEDDNVSNDSNDF Q8K2P7-3 coupled neutral amino K37(Dimethyl) 1 4729.135 3.08 TEVENGQINSKFISDR acid transporter 1 5-oxoprolinase N-Term(Dimethyl); SGLFVVGPESAGAHPGPACYR E9Q484 4 2157.052 3.09 (Fragment) C19(Carbamidomethyl) 5-oxoprolinase N-Term(Dimethyl:2H(6)13C(2)); SGLFVVGPESAGAHPGPACYR E9Q484 1 2165.089 3.93 (Fragment) C19(Carbamidomethyl) Cystathionine gamma- N-Term(Dimethyl); SGNPTRNCLEK Q8VCN5 1 1331.673 2.29 lyase C8(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cystathionine gamma- SGNPTRNCLEK Q8VCN5 C8(Carbamidomethyl); 2 1347.760 2.05 lyase K11(HeavyDimethyl) 60S ribosomal protein SGQGAFGNMCR Q9D8E6 C10(Carbamidomethyl) 1 1184.494 1.96 L4 60S ribosomal protein N-Term(Dimethyl); SGQGAFGNMCR Q9D8E6 7 1212.524 3.26 L4 C10(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); M9(Oxidation); SGQGAFGNMCR Q9D8E6 2 1228.516 2.71 L4 C10(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); SGQGAFGNMCR Q9D8E6 4 1220.566 2.76 L4 C10(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); SGQGAFGNMCR Q9D8E6 4 1236.561 2.89 L4 M9(Oxidation); C10(Carbamidomethyl) Bromodomain and WD SGQIEGVRQMHNNAPR A2AHJ4 repeat-containing protein M10(Oxidation) 2 1809.877 2.17 3 Aldehyde N-Term(Dimethyl); K8(Dimethyl); SGQQEGAKLLCGGGAAADR P47738 dehydrogenase, 5 1901.943 4.03 C11(Carbamidomethyl) mitochondrial RIKEN cDNA SGRDVWEEDQDNAVK Q8BVT3 1700013E18, isoform K15(HeavyDimethyl) 1 1783.889 2.09 CRA_b Isoform 2 of NADH dehydrogenase N-Term(Dimethyl); SGRFCCEPAGGLTSLTEPPKGPGFGVQ Q9D6J6-2 [ubiquinone] C5(Carbamidomethyl); 2 3103.537 3.40 AGL flavoprotein 2, C6(Carbamidomethyl); K20(Dimethyl) mitochondrial Isoform 2 of NADH N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase SGRFCCEPAGGLTSLTEPPKGPGFGVQ C5(Carbamidomethyl); Q9D6J6-2 [ubiquinone] 2 3119.626 3.61 AGL C6(Carbamidomethyl); flavoprotein 2, K20(HeavyDimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); SGSKFPVFNMSYNPAENAVLLCTR Q8CIE6 Coatomer subunit alpha K4(HeavyDimethyl); 1 2774.464 2.54 C22(Carbamidomethyl) SGSLSNVAGGRSTGGHALHAGSEGVK Q6P9K8-2 Isoform 2 of Caskin-1 K26(Dimethyl); K35(Dimethyl) 2 3402.825 3.27 LLATVLSQK Protein 2810007J24Rik N-Term(Dimethyl); SGTHWLNEIVCLILTK E9QAK1 1 1940.083 2.40 (Fragment) C11(Carbamidomethyl); K16(Dimethyl)

Sulfotransferase 1 family N-Term(Dimethyl); K21(Dimethyl); SGTTWVSEILDLIYNNGDAEKCKR Q3UZZ6 8 2853.451 3.70 member D1 C22(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sulfotransferase 1 family K21(HeavyDimethyl); SGTTWVSEILDLIYNNGDAEKCKR Q3UZZ6 1 2877.592 3.38 member D1 C22(Carbamidomethyl); K23(HeavyDimethyl) Bifunctional purine SGVAYIVAPSGSTADKVVIEACDELGI N-Term(Dimethyl); K16(Dimethyl); Q9CWJ9 biosynthesis protein 2 3682.911 3.53 VLAHTDLR C22(Carbamidomethyl) PURH Bifunctional purine N-Term(Dimethyl:2H(6)13C(2)); SGVAYIVAPSGSTADKVVIEACDELGI Q9CWJ9 biosynthesis protein K16(HeavyDimethyl); 1 3699.015 3.25 VLAHTDLR PURH C22(Carbamidomethyl) Isoform 2 of KN motif C9(Carbamidomethyl); and ankyrin repeat SHEVVETMCPLPTATTGNVHTAKK Q8BX02-2 K23(HeavyDimethyl); 2 2680.415 2.79 domain-containing K24(HeavyDimethyl) protein 2 Ras-related protein Rab- SHKPLMLSQLPDNR O35963 N-Term(Dimethyl); K3(Dimethyl) 1 1691.934 2.40 33B N-Term(Dimethyl:2H(6)13C(2)); SHPFSVIYRYFPGFDWFFLDPITSSGIKF Monoacylglycerol lipase Q99LR1 K28(HeavyDimethyl); M35(Oxidation); 1 4397.225 2.76 ANDENMK ABHD12 K36(HeavyDimethyl) 3'(2'),5'-bisphosphate N-Term(Dimethyl); SHSNQLVTDCISAMNPDTVLR D3Z0E6 1 2386.142 4.26 nucleotidase 1 C10(Carbamidomethyl) 3'(2'),5'-bisphosphate N-Term(Dimethyl:2H(6)13C(2)); SHSNQLVTDCISAMNPDTVLR D3Z0E6 1 2394.198 5.00 nucleotidase 1 C10(Carbamidomethyl) MCG131701, isoform SHYIGTKSMAALTVMAAAPAGMETDR Q3TDE2 K7(Dimethyl) 1 2708.336 2.44 CRA_b N-Term(Dimethyl); SIAQYWLGCPTSEK P29788 Vitronectin 1 1695.832 3.05 C9(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SIAQYWLGCPTSEK P29788 Vitronectin C9(Carbamidomethyl); 3 1711.922 3.33 K14(HeavyDimethyl) Thyroid hormone- N-Term(Dimethyl); SICVEVDHGLLPREEWQAK Q62264 2 2322.185 2.99 inducible hepatic protein C3(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Thyroid hormone- SICVEVDHGLLPREEWQAK Q62264 C3(Carbamidomethyl); 3 2338.270 4.07 inducible hepatic protein K19(HeavyDimethyl) Delta(24)-sterol SIFWELQDIIPFGNNPIFR Q8VCH6 2 2306.213 2.34 reductase Alpha-aminoadipic SIGPLTFVFTGTGNVSKGAQEVFNELP N-Term(Dimethyl); K17(Dimethyl); Q99K67 semialdehyde synthase, 2 4178.082 4.25 CEYVEPHELR C28(Carbamidomethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); SIGPLTFVFTGTGNVSKGAQEVFNELP Q99K67 semialdehyde synthase, K17(HeavyDimethyl); 3 4194.191 4.08 CEYVEPHELR mitochondrial C28(Carbamidomethyl) N-Term(Dimethyl); SIGYDDTDESHCVEHIESR P43883 Perilipin-2 1 2276.968 4.05 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SIGYDDTDESHCVEHIESR P43883 Perilipin-2 2 2285.020 4.02 C12(Carbamidomethyl) T-complex protein 1 N-Term(Dimethyl); SIHDALCVIR P80316 2 1211.651 2.70 subunit epsilon C7(Carbamidomethyl) Isoform 2 of Thrombospondin type-1 N-Term(Dimethyl:2H(6)13C(2)); SIINGNWAIDRPGK Q3UTY6-2 1 1612.992 2.03 domain-containing K14(HeavyDimethyl) protein 4 N-Term(Dimethyl:2H(6)13C(2)); Prostaglandin E synthase SILCCLR D3Z7C6 C4(Carbamidomethyl); 2 957.540 2.01 3 C5(Carbamidomethyl) N-Term(Dimethyl); SILEGSDEYLVCK P01872 Ig mu chain C region 1 1568.783 2.37 C12(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SILEGSDEYLVCK P01872 Ig mu chain C region C12(Carbamidomethyl); 1 1584.877 2.21 K13(HeavyDimethyl) N-Term(Dimethyl); SILEGSDEYLVCKIHYGGK P01872 Ig mu chain C region C12(Carbamidomethyl); K13(Dimethyl); 1 2252.176 2.73 K19(Dimethyl) Isoform 2 of SIPQEAVQTLSSVR Q8CD92-2 Tetratricopeptide repeat 1 1514.818 2.00 protein 27 WD repeat-containing N-Term(Dimethyl:2H(6)13C(2)); SIQCLTVHR O88342 1 1149.660 1.96 protein 1 C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase SIQEVLVEMTDGGVDYSFECIGNVK P28474 C20(Carbamidomethyl); 1 2861.413 2.78 class-3 K25(HeavyDimethyl) N-Term(Dimethyl); SIQFVDWCPTGFK P68368 Tubulin alpha-4A chain 4 1640.814 3.55 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SIQFVDWCPTGFK P68368 Tubulin alpha-4A chain C8(Carbamidomethyl); 5 1656.902 3.74 K13(HeavyDimethyl) N-Term(Dimethyl); SIQFVDWCPTGFKVGINYQPPTVVPGG P68368 Tubulin alpha-4A chain C8(Carbamidomethyl); K13(Dimethyl); 2 3474.816 5.59 DLAK K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SIQFVDWCPTGFKVGINYQPPTVVPGG C8(Carbamidomethyl); P68368 Tubulin alpha-4A chain 1 3498.952 5.57 DLAK K13(HeavyDimethyl); K31(HeavyDimethyl) Dihydropyrimidinase- N-Term(Dimethyl); SITIANQTNCPLYVTK O08553 4 1878.998 3.53 related protein 2 C10(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dihydropyrimidinase- SITIANQTNCPLYVTK O08553 C10(Carbamidomethyl); 1 1895.084 3.32 related protein 2 K16(HeavyDimethyl) Apoptosis-inducing N-Term(Dimethyl); SITVIGGGFLGSELACALGR B1AU25 1 2006.077 2.38 factor 1, mitochondrial C16(Carbamidomethyl) Apoptosis-inducing N-Term(Dimethyl); SITVIGGGFLGSELACALGRK B1AU25 2 2162.213 2.80 factor 1, mitochondrial C16(Carbamidomethyl); K21(Dimethyl)

Isoform 2 of Acyl- N-Term(Dimethyl); SIVTSDALAPQVDAISADCPSLQTK Q8BGA8-2 coenzyme A synthetase 2 2643.367 3.42 C19(Carbamidomethyl); K25(Dimethyl) ACSM5, mitochondrial

Isoform 2 of Acyl- N-Term(Dimethyl:2H(6)13C(2)); SIVTSDALAPQVDAISADCPSLQTK Q8BGA8-2 coenzyme A synthetase C19(Carbamidomethyl); 2 2659.439 4.48 ACSM5, mitochondrial K25(HeavyDimethyl) Ribosyldihydronicotina N-Term(Dimethyl:2H(6)13C(2)); SIWKEEPIHCTPPWYFQE Q9JI75 mide dehydrogenase K4(HeavyDimethyl); 3 2419.238 2.98 [quinone] C10(Carbamidomethyl) 3-alpha-hydroxysteroid N-Term(Dimethyl); K2(Dimethyl); SKDIILVSYCTLGSSR Q91WT7 1 1855.002 2.85 dehydrogenase type 1 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-alpha-hydroxysteroid SKDIILVSYCTLGSSR Q91WT7 K2(HeavyDimethyl); 2 1871.082 3.57 dehydrogenase type 1 C10(Carbamidomethyl) NAD-dependent protein N-Term(Dimethyl); K2(Dimethyl); SKEPNPGHLAIAQCEAR Q8K2C6 deacylase sirtuin-5, 2 1933.999 2.82 C14(Carbamidomethyl) mitochondrial

NAD-dependent protein N-Term(Dimethyl:2H(6)13C(2)); SKEPNPGHLAIAQCEAR Q8K2C6 deacylase sirtuin-5, K2(HeavyDimethyl); 2 1950.080 2.30 mitochondrial C14(Carbamidomethyl) Adenosylhomocysteinas K2(HeavyDimethyl); SKFDNLYGCR P50247 1 1295.653 2.11 e C9(Carbamidomethyl) Adenosylhomocysteinas N-Term(Dimethyl); K2(Dimethyl); SKFDNLYGCR P50247 13 1315.642 3.19 e C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas SKFDNLYGCR P50247 K2(HeavyDimethyl); 9 1331.731 2.80 e C9(Carbamidomethyl) Adenosylhomocysteinas N-Term(Dimethyl); K2(Dimethyl); SKFDNLYGCRESLIDGIK P50247 1 2199.142 3.12 e C9(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas K2(HeavyDimethyl); SKFDNLYGCRESLIDGIK P50247 1 2223.287 2.68 e C9(Carbamidomethyl); K18(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); SKGFGFVCFSSPEEATK D3Z5M2 Protein Gm10110 1 1961.966 2.56 C8(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); SKGFGFVCFSSPEEATK D3Z5M2 Protein Gm10110 2 1986.103 2.75 C8(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SKHPNGEERTGNNYR E9Q160 Protein Tro 2 1830.990 2.06 K2(HeavyDimethyl) 2-amino-3-ketobutyrate N-Term(Dimethyl); K2(Dimethyl); SKMEAAGFTVSGADHPICPVMLGDAR E9PWY6 coenzyme A ligase, 6 2773.338 4.14 C18(Carbamidomethyl) mitochondrial

2-amino-3-ketobutyrate N-Term(Dimethyl:2H(6)13C(2)); SKMEAAGFTVSGADHPICPVMLGDAR E9PWY6 coenzyme A ligase, K2(HeavyDimethyl); 1 2789.420 3.89 mitochondrial C18(Carbamidomethyl) RIKEN cDNA SKPFSSFGMAYDFIDSVGNDVDVVSDS K2(Dimethyl); K31(Dimethyl); D3YZE7 2700050L05, isoform 1 3581.732 2.86 ENIKK K32(Dimethyl) CRA_b N-Term(Dimethyl:2H(6)13C(2)); RIKEN cDNA K2(HeavyDimethyl); M9(Oxidation); SKPFSSFGMAYDFIDSVGNDVDVVSDS D3YZE7 2700050L05, isoform K31(HeavyDimethyl); 1 4048.232 3.03 ENIKKLLK CRA_b K32(HeavyDimethyl); K35(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); SKPLTPSTGAKEKEQHVALVTSTLPPL Isoform 2 of Cyclin- Q69ZA1-2 K11(HeavyDimethyl); 1 4127.534 3.06 PLPPMLPEDK dependent kinase 13 K13(HeavyDimethyl); K37(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); SKPVFDFLTILQCCPTSDGAAAAILSSE Non-specific lipid- P32020 C13(Carbamidomethyl); 7 4390.218 5.39 EFVQQYGLQSK transfer protein C14(Carbamidomethyl); K39(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); SKPVFDFLTILQCCPTSDGAAAAILSSE Non-specific lipid- P32020 C13(Carbamidomethyl); 5 4414.363 7.23 EFVQQYGLQSK transfer protein C14(Carbamidomethyl); K39(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SKPYQSNNFSLAFVPNTPLPQGEGLLT Q61967 Zinc finger protein 90 K2(HeavyDimethyl); 1 3383.918 3.06 EVK K30(HeavyDimethyl) Transformation/transcrip N-Term(Dimethyl); K2(Dimethyl); SKSEQESGNGRDVLMR F7CGG2 tion domain-associated 1 1864.903 2.29 M15(Oxidation) protein (Fragment) Armadillo repeat- N-Term(Dimethyl); K2(Dimethyl); SKVEVNVGPENGPGVK Q9CX83 containing X-linked 1 1693.954 2.35 K16(Dimethyl) protein 1 Cytochrome c oxidase N-Term(Dimethyl); SLCPVSWVSAWDDR P56391 6 1705.798 3.61 subunit 6B1 C3(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl:2H(6)13C(2)); SLCPVSWVSAWDDR P56391 8 1713.848 4.03 subunit 6B1 C3(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl); SLCPVSWVSAWDDRIAEGTFPGKI P56391 18 2747.391 5.42 subunit 6B1 C3(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytochrome c oxidase SLCPVSWVSAWDDRIAEGTFPGKI P56391 C3(Carbamidomethyl); 16 2763.467 5.14 subunit 6B1 K23(HeavyDimethyl) Isoform 2 of Mannose- N-Term(Dimethyl:2H(6)13C(2)); SLCTELQGTVAIPR P39039-2 1 1580.888 2.90 binding protein A C3(Carbamidomethyl) N-Term(Dimethyl); SLDINCPR Q05421 Cytochrome P450 2E1 6 1002.501 2.42 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SLDINCPR Q05421 Cytochrome P450 2E1 6 1010.547 2.15 C6(Carbamidomethyl) Acidic leucine-rich nuclear phosphoprotein N-Term(Dimethyl); SLDLFNCEVTNLNAYRENVFK F6UFG6 1 2602.298 2.59 32 family member A C7(Carbamidomethyl); K21(Dimethyl) (Fragment)

Acidic leucine-rich N-Term(Dimethyl:2H(6)13C(2)); nuclear phosphoprotein SLDLFNCEVTNLNAYRENVFK F6UFG6 C7(Carbamidomethyl); 3 2618.388 3.52 32 family member A K21(HeavyDimethyl) (Fragment) N-Term(Dimethyl:2H(6)13C(2)); Protein phosphatase 1 SLEEECESSLCTPALR Q3TDD9 C6(Carbamidomethyl); 1 1916.907 2.79 regulatory subunit 21 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SLEGGVVVPVDYHLLMMFTKAEHNAP Xyloside M16(Oxidation); M17(Oxidation); Q3U4G3 1 3434.889 2.95 LQAK xylosyltransferase 1 K20(HeavyDimethyl); K30(HeavyDimethyl) 40S ribosomal protein N-Term(Dimethyl); K4(Dimethyl); SLEKVCADLIR P60867 6 1359.765 3.62 S20 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein SLEKVCADLIR P60867 K4(HeavyDimethyl); 6 1375.854 2.93 S20 C6(Carbamidomethyl) K16(HeavyDimethyl); SLELHEEFGYNADTQKLLAKNGETLL E9QAY5 Protein Arfip1 K20(HeavyDimethyl); 1 4730.628 3.23 GAINFFIASVNTLVNK K42(HeavyDimethyl) N-Term(Dimethyl); SLEQWVTEEAGHLCDAFTK Q8CIM7 Cytochrome P450 2D26 3 2277.090 4.71 C14(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SLEQWVTEEAGHLCDAFTK Q8CIM7 Cytochrome P450 2D26 C14(Carbamidomethyl); 9 2293.178 5.08 K19(HeavyDimethyl) N-Term(Dimethyl); SLEQWVTEEAGHLCDAFTKEAEHPFN Q8CIM7 Cytochrome P450 2D26 C14(Carbamidomethyl); K19(Dimethyl); 2 3851.918 4.00 PSPLLSK K33(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SLEQWVTEEAGHLCDAFTKEAEHPFN C14(Carbamidomethyl); Q8CIM7 Cytochrome P450 2D26 1 3876.040 3.33 PSPLLSK K19(HeavyDimethyl); K33(HeavyDimethyl) Alpha/beta hydrolase SLGGAVAIHLASENSHRISAIMVENTFL Q80UX8 domain-containing N-Term(Dimethyl); M22(Oxidation) 1 4831.473 3.33 SIPHMASTLFSFFPMR protein 13 60S ribosomal protein N-Term(Dimethyl); K4(Dimethyl); SLGKFGIICMEDLIHEIYTVGKR P14148 1 2763.515 3.45 L7 C9(Carbamidomethyl); K22(Dimethyl) T-complex protein 1 N-Term(Dimethyl:2H(6)13C(2)); SLHDALCVIR P80316 4 1219.702 2.83 subunit epsilon C7(Carbamidomethyl) N-Term(Dimethyl); K9(Dimethyl); SLHTLFGDKLCAIPNLR P07724 Serum albumin 1 2011.124 2.78 C11(Carbamidomethyl) Farnesyl pyrophosphate N-Term(Dimethyl); SLIEQCSAPLPPSIFMELANK Q920E5 2 2401.250 2.96 synthase C6(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Farnesyl pyrophosphate SLIEQCSAPLPPSIFMELANK Q920E5 C6(Carbamidomethyl); 3 2417.344 3.21 synthase K21(HeavyDimethyl) K3(HeavyDimethyl); M21(Oxidation); SLKSLQLDYVDLYLIHYPVPMKPGDNE Q9JLI0 Aldo-keto reductase a K22(HeavyDimethyl); 1 4112.224 3.39 SPLDENGK K35(HeavyDimethyl) ATP-sensitive inward SLLDALTLASSRGPLR Q61743 rectifier potassium 2 1669.941 2.24 channel 11 SLLDSDHHPSEIAESHRFCDRVQDAYT N-Term(Dimethyl); P35492 Histidine ammonia-lyase 1 3482.634 3.39 LR C19(Carbamidomethyl) SLLDSDHHPSEIAESHRFCDRVQDAYT N-Term(Dimethyl:2H(6)13C(2)); P35492 Histidine ammonia-lyase 1 3490.675 3.26 LR C19(Carbamidomethyl) N-Term(Dimethyl); Aldo-keto reductase C9(Carbamidomethyl); SLLDTVDFCDTWERLEECKDAGLVK Q8VC28 1 3083.509 2.65 family 1 member C13 C18(Carbamidomethyl); K19(Dimethyl); K25(Dimethyl) N-Term(Dimethyl); SLLELQMSSNPLGDEGVQELCK Q91VI7 Ribonuclease inhibitor 1 2503.254 5.39 C21(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SLLELQMSSNPLGDEGVQELCK Q91VI7 Ribonuclease inhibitor C21(Carbamidomethyl); 1 2519.321 4.07 K22(HeavyDimethyl) K5(HeavyDimethyl); SLLGKDVLFLKDCVGPEVENACANPA Phosphoglycerate kinase K11(HeavyDimethyl); P09411 2 4068.195 3.34 AGTVILLENLR 1 C13(Carbamidomethyl); C22(Carbamidomethyl) N-Term(Dimethyl); K5(Dimethyl); SLLGKDVLFLKDCVGPEVENACANPA Phosphoglycerate kinase P09411 K11(Dimethyl); C13(Carbamidomethyl); 5 4080.219 6.39 AGTVILLENLR 1 C22(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K5(HeavyDimethyl); SLLGKDVLFLKDCVGPEVENACANPA Phosphoglycerate kinase P09411 K11(HeavyDimethyl); 4 4104.336 5.67 AGTVILLENLR 1 C13(Carbamidomethyl); C22(Carbamidomethyl) Persulfide dioxygenase N-Term(Dimethyl); SLLPGCQSVISR Q9DCM0 1 1344.725 2.15 ETHE1, mitochondrial C6(Carbamidomethyl)

Persulfide dioxygenase N-Term(Dimethyl:2H(6)13C(2)); SLLPGCQSVISR Q9DCM0 2 1352.771 2.33 ETHE1, mitochondrial C6(Carbamidomethyl) Bile acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); SLMPDVYQAVCEGTWNL Q4LDG0 2 2018.978 2.48 synthetase C11(Carbamidomethyl) Histidine triad N-Term(Dimethyl); SLPADILYEDQQCLVFR Q9D0S9 nucleotide-binding 3 2095.070 3.86 C13(Carbamidomethyl) protein 2, mitochondrial

Histidine triad N-Term(Dimethyl:2H(6)13C(2)); SLPADILYEDQQCLVFR Q9D0S9 nucleotide-binding 2 2103.093 4.01 C13(Carbamidomethyl) protein 2, mitochondrial

Histidine triad SLPADILYEDQQCLVFRDVAPQAPVHF N-Term(Dimethyl); Q9D0S9 nucleotide-binding 10 3734.994 5.61 LVIPR C13(Carbamidomethyl) protein 2, mitochondrial

Histidine triad SLPADILYEDQQCLVFRDVAPQAPVHF N-Term(Dimethyl:2H(6)13C(2)); Q9D0S9 nucleotide-binding 3 3743.012 3.76 LVIPR C13(Carbamidomethyl) protein 2, mitochondrial Histidine triad N-Term(Dimethyl:2H(6)13C(2)); SLPADILYEDQQCLVFRDVAPQAPVHF Q9D0S9 nucleotide-binding C13(Carbamidomethyl); 1 4370.495 3.34 LVIPRKPIPR protein 2, mitochondrial K33(HeavyDimethyl) TBC1 domain family SLPEHPAFQSDTGISALR A3KGB4 1 1925.996 2.06 member 8B N-Term(Dimethyl); K7(Dimethyl); SLPQPQKVNSILGCSQ Q91X72 Hemopexin 17 1811.965 4.04 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SLPQPQKVNSILGCSQ Q91X72 Hemopexin K7(HeavyDimethyl); 10 1828.052 3.82 C14(Carbamidomethyl)

N-Term(Dimethyl); Sarcoplasmic/endoplasm SLPSVETLGCTSVICSDKTGTLTTNQM C10(Carbamidomethyl); Q8R429 ic reticulum calcium 1 3458.657 2.99 SVCK C15(Carbamidomethyl); K18(Dimethyl); ATPase 1 C30(Carbamidomethyl); K31(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Sarcoplasmic/endoplasm C10(Carbamidomethyl); SLPSVETLGCTSVICSDKTGTLTTNQM O55143 ic reticulum calcium C15(Carbamidomethyl); 1 3474.761 2.83 SVCR ATPase 2 K18(HeavyDimethyl); C30(Carbamidomethyl) N-Term(Dimethyl); SLSEDCEVGGYKVTK Q9DBW0 Cytochrome P450 4V2 C6(Carbamidomethyl); K12(Dimethyl); 3 1755.878 3.48 K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C6(Carbamidomethyl); SLSEDCEVGGYKVTK Q9DBW0 Cytochrome P450 4V2 2 1780.006 3.22 K12(HeavyDimethyl); K15(HeavyDimethyl) C5(Carbamidomethyl); Suppression of SLSGCPIAAAEKLAMTQDKSQLDSSQT K12(HeavyDimethyl); Q80TY4 tumorigenicity 18 1 3972.993 3.46 GQCPEQAHR K19(HeavyDimethyl); protein C30(Carbamidomethyl) Ig heavy chain V region N-Term(Dimethyl); SLTSEDSAVYYCAR P06330 2 1649.744 2.94 AC38 205.12 C12(Carbamidomethyl) Isoform 2 of Probable N-Term(Dimethyl); M7(Oxidation); SLTWIHMLVTVGSILSYFFFALAFGAL Q8K2X1-2 phospholipid- C28(Carbamidomethyl); 1 4795.367 3.51 CVTCNPPSNPYGIMR transporting ATPase VD C31(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of SLVANLAAANCYK P55264-2 C11(Carbamidomethyl); 4 1466.861 3.37 Adenosine kinase K13(HeavyDimethyl) N-Term(Dimethyl); Isoform Short of SLVANLAAANCYKK P55264-2 C11(Carbamidomethyl); K13(Dimethyl); 10 1606.892 4.30 Adenosine kinase K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of C11(Carbamidomethyl); SLVANLAAANCYKK P55264-2 15 1631.026 4.59 Adenosine kinase K13(HeavyDimethyl); K14(HeavyDimethyl) N-Term(Dimethyl); Isoform Short of SLVANLAAANCYKKEK P55264-2 C11(Carbamidomethyl); K13(Dimethyl); 5 1892.063 3.93 Adenosine kinase K14(Dimethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C11(Carbamidomethyl); Isoform Short of SLVANLAAANCYKKEK P55264-2 K13(HeavyDimethyl); 11 1924.235 3.96 Adenosine kinase K14(HeavyDimethyl); K16(HeavyDimethyl) SLVCWPSSEGTLSWPDLLSDPSVVSST N-Term(Dimethyl); O08852 Polycystin-1 1 3331.651 2.85 LQR C4(Carbamidomethyl) Inhibitor of nuclear SLVGYSLEGTVTPPVSAWLPPTLADR E9Q605 factor kappa-B kinase N-Term(Dimethyl:2H(6)13C(2)) 1 2762.492 2.56 subunit alpha Sarcosine SLYPLMNVDDLYGTLYVPQDGTMDP N-Term(Dimethyl); Q99LB7 dehydrogenase, 3 3806.796 4.97 AGTCTTLTR C29(Carbamidomethyl) mitochondrial Sarcosine SLYPLMNVDDLYGTLYVPQDGTMDP N-Term(Dimethyl); M23(Oxidation); Q99LB7 dehydrogenase, 1 3822.811 3.40 AGTCTTLTR C29(Carbamidomethyl) mitochondrial Sarcosine SLYPLMNVDDLYGTLYVPQDGTMDP N-Term(Dimethyl:2H(6)13C(2)); Q99LB7 dehydrogenase, 3 3814.858 4.75 AGTCTTLTR C29(Carbamidomethyl) mitochondrial Sarcosine SLYPLMNVDDLYGTLYVPQDGTMDP N-Term(Dimethyl:2H(6)13C(2)); Q99LB7 dehydrogenase, 1 3830.847 2.77 AGTCTTLTR M23(Oxidation); C29(Carbamidomethyl) mitochondrial Sarcosine SLYPLMNVDDLYGTLYVPQDGTMDP N-Term(Dimethyl:2H(6)13C(2)); Q99LB7 dehydrogenase, 1 3830.843 3.07 AGTCTTLTR M6(Oxidation); C29(Carbamidomethyl) mitochondrial Receptor-type tyrosine- N-Term(Dimethyl); M6(Oxidation); SLYYDMNKLDPQTNSSQIK P28828 1 2345.148 2.45 protein phosphatase mu K8(Dimethyl); K19(Dimethyl)

Isoform 2 of TRAF-type N-Term(Dimethyl:2H(6)13C(2)); SMAAQFPVQNNLFEEQER Q3UDK1-2 zinc finger domain- 1 2190.082 2.28 M2(Oxidation) containing protein 1 SMDVIAEQRRTHITMALSWMTIVVPLL M2(Oxidation); M15(Oxidation); Q3TYW3 Protein BC023829 1 4260.408 3.20 TFEILLVHK K36(HeavyDimethyl) Serine/threonine-protein SMLGLGQLSTVITQVNGVHANR Q9JKK8 N-Term(Dimethyl:2H(6)13C(2)) 1 2331.285 2.44 kinase ATR SMLLGMGFPPVDIFSPLVLGIMAVALG Protein 0610031J06Rik H3BJ16 M6(Oxidation) 1 4417.393 2.84 APGLMFLGGGLFLLLR (Fragment) SMLQSLSQNPDLAAQMQNPDTLSAMS Q8R317-2 Isoform 2 of Ubiquilin-1 M16(Oxidation) 1 3161.492 2.82 NPR N-Term(Dimethyl:2H(6)13C(2)); C13(Carbamidomethyl); SMMQDREDQSILCTGESGAGKTENTK Q8VDD5 Myosin-9 1 2981.525 3.18 K21(HeavyDimethyl); K26(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SMSLTLQSSPIITLEPVETVVDAGGR D3Z2Q7 Protein Hmcn1 1 2752.457 2.83 M2(Oxidation) Sarcoplasmic/endoplasm N-Term(Dimethyl:2H(6)13C(2)); SMSVYCTPNKPSR O55143 ic reticulum calcium C6(Carbamidomethyl); 1 1598.860 2.05 ATPase 2 K10(HeavyDimethyl) Isoform 2 of 2- SMTCPSTGLEEDVLFHIGKVASSVPVE oxoglutarate N-Term(Dimethyl); Q60597-2 1 4028.037 3.53 NFTIHGGLSR dehydrogenase, C4(Carbamidomethyl); K19(Dimethyl) mitochondrial Probable proline N-Term(Dimethyl); K8(Dimethyl); SMTQLQGKEDCTQPDYEATSR Q8VCZ9 1 2501.106 3.57 dehydrogenase 2 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Probable proline SMTQLQGKEDCTQPDYEATSR Q8VCZ9 K8(HeavyDimethyl); 1 2517.206 3.41 dehydrogenase 2 C11(Carbamidomethyl) Isoform 2 of Glutamate SNAPATLTFENMAGVFMLVAGGIVAG N-Term(Dimethyl:2H(6)13C(2)); P35438-2 receptor ionotropic, 1 3977.231 3.13 IFLIFIEIAYK M12(Oxidation); K37(HeavyDimethyl) NMDA 1 Apoptosis-inducing N-Term(Dimethyl); SNIWVAGDAACFYDIK B1AU25 1 1885.917 3.12 factor 1, mitochondrial C11(Carbamidomethyl); K16(Dimethyl) Glutaminase liver N-Term(Dimethyl); SNPDLWGVSLCTVDGQR Q571F8 7 1931.926 3.95 isoform, mitochondrial C11(Carbamidomethyl) Glutaminase liver N-Term(Dimethyl:2H(6)13C(2)); SNPDLWGVSLCTVDGQR Q571F8 12 1939.969 3.89 isoform, mitochondrial C11(Carbamidomethyl) Isoform 2 of Centromere N-Term(Dimethyl); SNPGGFGIAPHCLDEGTVR Q9CXS4-2 7 2011.969 3.67 protein V C12(Carbamidomethyl) Isoform 2 of Centromere N-Term(Dimethyl:2H(6)13C(2)); SNPGGFGIAPHCLDEGTVR Q9CXS4-2 1 2020.006 3.74 protein V C12(Carbamidomethyl) SNQGIFPSGLQCVTILIGVYDLQTGLPL Inositol polyphosphate 1- N-Term(Dimethyl); P49442 1 4918.608 2.93 MGVINQPFASQNLTTLR phosphatase C12(Carbamidomethyl); M29(Oxidation)

N-Term(Dimethyl); SNSAPRNSGSMANRPPCSPK Q8C5J9 Protein 4732471J01Rik 1 2171.073 2.65 C17(Carbamidomethyl); K20(Dimethyl) SNTGGQAFPQCVFDHWQILPGDPFDNS N-Term(Dimethyl); P58252 Elongation factor 2 2 4273.015 3.95 SRPSQVVAETR C11(Carbamidomethyl) SNTGGQAFPQCVFDHWQILPGDPFDNS N-Term(Dimethyl:2H(6)13C(2)); P58252 Elongation factor 2 1 4281.073 3.25 SRPSQVVAETR C11(Carbamidomethyl) UDP- N-Term(Dimethyl); SNWDLEFPHPTLPNVDYVGGLHCKPA P17717 glucuronosyltransferase C23(Carbamidomethyl); K24(Dimethyl); 1 3638.927 3.14 KPLPK 2B17 K27(Dimethyl); K31(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); UDP- C23(Carbamidomethyl); SNWDLEFPHPTLPNVDYVGGLHCKPA P17717 glucuronosyltransferase K24(HeavyDimethyl); 1 3671.125 3.10 KPLPK 2B17 K27(HeavyDimethyl); K31(HeavyDimethyl) N-Term(Dimethyl); Fatty aldehyde C3(Carbamidomethyl); SPCYIDRDCDLDVACR P47740 1 2042.868 2.37 dehydrogenase C9(Carbamidomethyl); C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty aldehyde C3(Carbamidomethyl); SPCYIDRDCDLDVACR P47740 1 2050.923 2.27 dehydrogenase C9(Carbamidomethyl); C15(Carbamidomethyl) Phosphoribosyl SPDAAKRAQSYAER Q9D0M1 pyrophosphate synthase- K6(HeavyDimethyl) 1 1585.834 2.15 associated protein 1 Cytosolic 10- N-Term(Dimethyl); SPLIIFADCDLNK Q8R0Y6 formyltetrahydrofolate 1 1561.831 2.43 C9(Carbamidomethyl); K13(Dimethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); SPLIIFADCDLNK Q8R0Y6 formyltetrahydrofolate C9(Carbamidomethyl); 1 1577.912 2.46 dehydrogenase K13(HeavyDimethyl) Cytosolic 10- N-Term(Dimethyl); SPLIIFADCDLNKAVQMGMSSVFFNKG Q8R0Y6 formyltetrahydrofolate C9(Carbamidomethyl); K13(Dimethyl); 1 3944.972 3.53 ENCIAAGR dehydrogenase K26(Dimethyl); C30(Carbamidomethyl)

4- N-Term(Dimethyl); SPLIIFSDCNMENAVK Q9JLJ2 trimethylaminobutyralde 4 1893.938 3.11 C9(Carbamidomethyl); K16(Dimethyl) hyde dehydrogenase Nuclear factor of- N-Term(Dimethyl); M3(Oxidation); SPMLCGQYPVKSEGK F6VCW7 activated T-cells 5 C5(Carbamidomethyl); K11(Dimethyl); 1 1780.912 2.24 (Fragment) K15(Dimethyl) Isoform 2 of UDP- GalNAc:beta-1,3-N- SPPDPHNTGPSAADQSALFPHWK Q8BG28-2 K23(Dimethyl) 1 2485.188 2.88 acetylgalactosaminyltran sferase 2 DDB1- and CUL4- N-Term(Dimethyl:2H(6)13C(2)); SPPTMGPQQTGSR Q8CBW4 associated factor 12-like 1 1395.700 2.13 M5(Oxidation) protein 1 N-Term(Dimethyl); NAD(P)H-hydrate SPPTVLVICGPGNNGGDGLVCAR Q8K4Z3 C9(Carbamidomethyl); 2 2338.157 4.91 epimerase C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); NAD(P)H-hydrate SPPTVLVICGPGNNGGDGLVCAR Q8K4Z3 C9(Carbamidomethyl); 1 2346.202 4.11 epimerase C21(Carbamidomethyl) Isoform 2 of F-box/WD SPRRPEAGARGEPASGYLGLAQGLLEG Q8BIA4-4 repeat-containing protein N-Term(Dimethyl:2H(6)13C(2)) 1 3858.108 2.64 AGRPPAPRPGR 8 K6(HeavyDimethyl); SPSESKSSSTDPPQCTHSEDSLPSAAFY Protein 4930485B16Rik E9PZY5 C15(Carbamidomethyl); 1 3668.779 2.69 GPLDSK (Fragment) K34(HeavyDimethyl) Isoform 4 of Mediator of SPSHSSSNRPFTPPTSTGGSK Q925J9-4 RNA polymerase II K21(HeavyDimethyl) 1 2152.093 2.22 transcription subunit 1 SPSSEGSSSISTIKQDMLFQLSPSSME Q08EB1 4933432B09Rik protein K14(HeavyDimethyl); M26(Oxidation) 1 2912.353 2.89 N-Term(Dimethyl:2H(6)13C(2)); SPVDSPVPASMFAPEPSSPGAAR O08582 GTP-binding protein 1 1 2306.139 2.25 M11(Oxidation) Isoform 2 of SPVRELLEMEPETAKFSPAER Q8R418-2 M9(Oxidation); K15(HeavyDimethyl) 1 2468.278 3.06 Endoribonuclease Dicer C4(Carbamidomethyl); C5(Carbamidomethyl); SPYCCPECGVLCRSAYFQTHVKENCLH C8(Carbamidomethyl); Q8BHZ4 Zinc finger protein 592 1 3798.717 2.63 YAR C12(Carbamidomethyl); K22(HeavyDimethyl); C25(Carbamidomethyl) Isoform 2 of Ribosomal SQAQLSTRLSLMTPAELTPGHTLRQNR Q8R2S1-2 2 3006.564 3.30 protein S6 kinase-like 1 N-Term(Dimethyl); SQASCSLQHSDSEPVGICQGSTVQSSLR Q6YJU1 Fetuin-B C5(Carbamidomethyl); 2 3033.397 4.54 C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SQASCSLQHSDSEPVGICQGSTVQSSLR Q6YJU1 Fetuin-B C5(Carbamidomethyl); 1 3041.448 3.44 C18(Carbamidomethyl) Isocitrate dehydrogenase N-Term(Dimethyl); K7(Dimethyl); SQFEAQKICYEHR O88844 3 1751.846 3.02 [NADP] cytoplasmic C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase SQFEAQKICYEHR O88844 K7(HeavyDimethyl); 8 1767.932 3.54 [NADP] cytoplasmic C9(Carbamidomethyl) Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); SQKPRDSSVEVR O70194 initiation factor 3 1 1459.898 1.95 K3(HeavyDimethyl) subunit D BAG family molecular N-Term(Dimethyl); SQSPAASDCSSSSSSASLPSSGR Q9JLV1 1 2227.960 3.68 chaperone regulator 3 C9(Carbamidomethyl) Basement membrane- N-Term(Dimethyl:2H(6)13C(2)); specific heparan sulfate SQSVRPGADVTFICTAK B1B0C7 C14(Carbamidomethyl); 1 1909.078 2.03 proteoglycan core K17(HeavyDimethyl) protein Cytochrome b-c1 N-Term(Dimethyl); SQTEEDCTEELFDFLHAR P99028 complex subunit 6, 10 2254.985 5.48 C7(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); SQTEEDCTEELFDFLHAR P99028 complex subunit 6, 6 2263.035 4.25 C7(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); SQVLTFCVNPSMDGISIVSTGGHMPYR F6VBM2 Protein Gm10490 C7(Carbamidomethyl); M12(Oxidation); 1 3343.681 2.92 GTK M24(Oxidation); K30(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SRDIEVLEGMPLFAELSGNLVPVK F7D1P5 Ankyrin-1 (Fragment) 1 2685.518 2.79 K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adrenodoxin, C5(Carbamidomethyl); SRLGCQVCLTK P46656 1 1393.815 2.14 mitochondrial C8(Carbamidomethyl); K11(HeavyDimethyl) SRPGRTQDTTEPPAWHEDGGDQKEPC Transmembrane channel- B1ATB3 K23(Dimethyl); C26(Carbamidomethyl) 1 3346.516 2.97 NPR like protein Very long-chain-specific acyl-CoA N-Term(Dimethyl); SSAIPSPCGK B1AR28 1 1059.546 2.16 dehydrogenase, C8(Carbamidomethyl); K10(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); SSCTIIPLMK P19096 Fatty acid synthase C3(Carbamidomethyl); 3 1221.754 2.30 K10(HeavyDimethyl)

N-Term(Dimethyl); Poly(A) RNA SSDGDLCLVVKEEPCFFQVNQKTEAR Q91YI6 C7(Carbamidomethyl); K11(Dimethyl); 1 3140.498 2.31 polymerase GLD2 C15(Carbamidomethyl); K22(Dimethyl)

Aldehyde N-Term(Dimethyl); SSFANQGEICLCTSR Q8BH00 dehydrogenase family 8 C10(Carbamidomethyl); 4 1757.792 4.12 member A1 C12(Carbamidomethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); SSFANQGEICLCTSR Q8BH00 dehydrogenase family 8 C10(Carbamidomethyl); 9 1765.837 4.17 member A1 C12(Carbamidomethyl) Cytochrome c oxidase N-Term(Dimethyl); SSFEASCPQQWIK Q8BGD8 assembly factor 6 5 1623.781 3.39 C7(Carbamidomethyl); K13(Dimethyl) homolog Cytochrome c oxidase N-Term(Dimethyl:2H(6)13C(2)); SSFEASCPQQWIK Q8BGD8 assembly factor 6 C7(Carbamidomethyl); 1 1639.873 2.18 homolog K13(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); SSGEIVYCGQVFEK P62717 9 1658.804 3.34 L18a C8(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein SSGEIVYCGQVFEK P62717 C8(Carbamidomethyl); 4 1674.891 3.38 L18a K14(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); SSGEIVYCGQVFEKSPLR P62717 1 2112.072 3.54 L18a C8(Carbamidomethyl); K14(Dimethyl)

Isocitrate dehydrogenase N-Term(Dimethyl); SSGGFVWACK P54071 3 1154.564 2.48 [NADP], mitochondrial C9(Carbamidomethyl); K10(Dimethyl)

Isoform 2 of NAD N-Term(Dimethyl); SSGLNLCTGTGSK Q8C5H8-2 1 1337.666 2.11 kinase 2, mitochondrial C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of NAD SSGLNLCTGTGSK Q8C5H8-2 C7(Carbamidomethyl); 1 1353.760 2.90 kinase 2, mitochondrial K13(HeavyDimethyl) N-Term(Dimethyl); K8(Dimethyl); SSILLDVKPWDDETDMAQLETCVR D3YY68 Elongation factor 1-delta 1 2877.409 3.44 C22(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SSILLDVKPWDDETDMAQLETCVR D3YY68 Elongation factor 1-delta K8(HeavyDimethyl); 1 2893.488 2.77 C22(Carbamidomethyl) N-Term(Dimethyl); K8(Dimethyl); SSILLDVKPWDDETDMTKLEECVR O70251 Elongation factor 1-beta 1 2963.481 2.99 K18(Dimethyl); C22(Carbamidomethyl)

SSIYGRPGACYIDIPADFVTLQANVTSI 2-hydroxyacyl-CoA N-Term(Dimethyl); D3YZ54 3 3212.661 3.88 K lyase 1 C10(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SSIYGRPGACYIDIPADFVTLQANVTSI 2-hydroxyacyl-CoA D3YZ54 C10(Carbamidomethyl); 4 3228.765 4.70 K lyase 1 K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); SSIYGRPGACYIDIPADFVTLQANVTSI 2-hydroxyacyl-CoA C10(Carbamidomethyl); D3YZ54 3 3556.017 3.32 KYK lyase 1 K29(HeavyDimethyl); K31(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); K3(Dimethyl); SSKACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide 1 2841.407 3.02 C5(Carbamidomethyl) hydrolase 2 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); SSKACGANLPENFSISQIFSQAMAAR P34914-2 Bifunctional epoxide K3(HeavyDimethyl); 1 2857.492 3.51 hydrolase 2 C5(Carbamidomethyl) Macrophage mannose N-Term(Dimethyl); SSLSYEDADCVVVIGGNSR Q61830 1 2055.966 2.89 receptor 1 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); SSMMPGFFSDVNPLSAVSSVVNKFNPF Isoform 2 of Protein M4(Oxidation); K23(HeavyDimethyl); Q9QYX7-2 1 4839.542 3.55 DLISDSEAVQEETTKK piccolo K42(HeavyDimethyl); K43(HeavyDimethyl) M3(Oxidation); C23(Carbamidomethyl); Nuclear envelope pore SSMSEQILDTTLSSPSSNAPDPCAKETV K25(HeavyDimethyl); H7BX32 membrane protein POM 1 3873.051 2.68 LNALKEK K33(HeavyDimethyl); 121 K35(HeavyDimethyl) SSNLFSEVMQMNFEIASFSSLSGTQPIT Transmembrane protein Q8CEF9 N-Term(Dimethyl:2H(6)13C(2)) 1 4046.990 3.00 WQVEYPR 132C N-Term(Dimethyl:2H(6)13C(2)); SSRDQALAEQCLSALTQCAASGDGNIL Methylmalonyl-CoA P16332 C11(Carbamidomethyl); 3 3639.836 5.68 ALAVDAAR mutase, mitochondrial C18(Carbamidomethyl) N-Term(Dimethyl); SSTETCYSAIPK Q80X90 Filamin-B 4 1399.674 2.75 C6(Carbamidomethyl); K12(Dimethyl) Alpha-aminoadipic N-Term(Dimethyl); SSVVPVEGCPELPHK Q99K67 semialdehyde synthase, 2 1690.882 3.26 C9(Carbamidomethyl); K15(Dimethyl) mitochondrial

Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); SSVVPVEGCPELPHK Q99K67 semialdehyde synthase, C9(Carbamidomethyl); 2 1706.972 2.64 mitochondrial K15(HeavyDimethyl) Fructose-1,6- N-Term(Dimethyl); SSYATCVLVSEENTNAIIIEPEKR Q9QXD6 7 2779.412 6.02 bisphosphatase 1 C6(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fructose-1,6- SSYATCVLVSEENTNAIIIEPEKR Q9QXD6 C6(Carbamidomethyl); 5 2795.502 4.48 bisphosphatase 1 K23(HeavyDimethyl) N-Term(Dimethyl); STCNVIASLIFAR P11714 Cytochrome P450 2D9 2 1479.792 3.15 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); STCNVIASLIFAR P11714 Cytochrome P450 2D9 2 1487.828 2.36 C3(Carbamidomethyl) Alpha-aminoadipic N-Term(Dimethyl); STCTINYSTSLPLAQGIK G3UYR8 semialdehyde 5 2010.058 4.38 C3(Carbamidomethyl); K18(Dimethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); STCTINYSTSLPLAQGIK G3UYR8 semialdehyde C3(Carbamidomethyl); 1 2026.148 2.82 dehydrogenase K18(HeavyDimethyl) Alpha-aminoadipic N-Term(Dimethyl); STCTINYSTSLPLAQGIKFQ G3UYR8 semialdehyde 4 2285.181 4.03 C3(Carbamidomethyl); K18(Dimethyl) dehydrogenase Alpha-aminoadipic N-Term(Dimethyl:2H(6)13C(2)); STCTINYSTSLPLAQGIKFQ G3UYR8 semialdehyde C3(Carbamidomethyl); 7 2301.278 4.30 dehydrogenase K18(HeavyDimethyl) Isoform 2 of Probable N-Term(Dimethyl:2H(6)13C(2)); phospholipid- C3(Carbamidomethyl); STCYACRLFQTNTELLELTTK Q9QZW0-2 1 2621.358 2.58 transporting ATPase C6(Carbamidomethyl); 11C K21(HeavyDimethyl) Inorganic N-Term(Dimethyl); pyrophosphatase 2, C4(Carbamidomethyl); STDCCGDNDPIDVCEIGSK D3Z096 2 2197.901 5.23 mitochondrial C5(Carbamidomethyl); (Fragment) C14(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Inorganic C4(Carbamidomethyl); pyrophosphatase 2, STDCCGDNDPIDVCEIGSK D3Z096 C5(Carbamidomethyl); 2 2213.990 4.68 mitochondrial C14(Carbamidomethyl); (Fragment) K19(HeavyDimethyl) Dihydrolipoyl STDRVLGAHILGPGAGEMVNEAALAL N-Term(Dimethyl); O08749 dehydrogenase, 1 3841.876 5.58 EYGASCEDIAR C32(Carbamidomethyl) mitochondrial D-dopachrome STEPCAHLLVSSIGVVGTAEQNR O35215 C5(Carbamidomethyl) 2 2425.214 2.78 decarboxylase D-dopachrome N-Term(Dimethyl); STEPCAHLLVSSIGVVGTAEQNR O35215 3 2453.242 5.22 decarboxylase C5(Carbamidomethyl) D-dopachrome N-Term(Dimethyl:2H(6)13C(2)); STEPCAHLLVSSIGVVGTAEQNR O35215 6 2461.288 5.72 decarboxylase C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); STEPCAHLLVSSIGVVGTAEQNRTHSA D-dopachrome O35215 C5(Carbamidomethyl); 1 3402.809 3.13 SFFK decarboxylase K31(HeavyDimethyl) N-Term(Dimethyl); STLATSSSQPVWLTAMDCPTSGVVGL P19096 Fatty acid synthase C18(Carbamidomethyl); 4 3335.655 4.98 VNCLR C29(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); STLATSSSQPVWLTAMDCPTSGVVGL P19096 Fatty acid synthase C18(Carbamidomethyl); 3 3343.695 5.59 VNCLR C29(Carbamidomethyl) STLHVTTAPEPSDVSSAASPVALQWPG A2ADM8 Protein Zfp831 N-Term(Dimethyl); K31(Dimethyl) 1 4123.123 3.29 IGDKDSPLPSVPR N-Term(Dimethyl); STLTDSLVCK P58252 Elongation factor 2 3 1179.624 2.72 C9(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); STLTDSLVCK P58252 Elongation factor 2 C9(Carbamidomethyl); 2 1195.713 2.40 K10(HeavyDimethyl) Protein Tcp10a STMATGGTDSQDEMLSFTSVDEK D3Z3T8 N-Term(Dimethyl); K23(Dimethyl) 1 2493.127 2.39 (Fragment) Fission 1 (Mitochondrial outer membrane) N-Term(Dimethyl); STQFEYAWCLVR G3X9U9 1 1587.763 2.94 homolog (Yeast), C9(Carbamidomethyl) isoform CRA_c

Fission 1 (Mitochondrial outer membrane) N-Term(Dimethyl:2H(6)13C(2)); STQFEYAWCLVR G3X9U9 1 1595.804 2.12 homolog (Yeast), C9(Carbamidomethyl) isoform CRA_c

Isoform 9 of SH3 and STSMQDTVREGRGIPPPPQTAPPPPPAP Q4ACU6-10 multiple ankyrin repeat M4(Oxidation) 1 4951.429 3.32 YYFDSGPPPTFSPPPPPGR domains protein 3

N-Term(Dimethyl:2H(6)13C(2)); Cation-independent C8(Carbamidomethyl); STTIYFYCDRTTQKPVFLKETSDCSYM Q07113 mannose-6-phosphate K14(HeavyDimethyl); 1 4084.015 2.79 FEWR receptor K19(HeavyDimethyl); C24(Carbamidomethyl); M27(Oxidation) Sarcosine N-Term(Dimethyl); STVCGPESFTPDHKPLMGEAPELR Q99LB7 dehydrogenase, 18 2711.300 5.04 C4(Carbamidomethyl); K14(Dimethyl) mitochondrial Sarcosine N-Term(Dimethyl); STVCGPESFTPDHKPLMGEAPELR Q99LB7 dehydrogenase, C4(Carbamidomethyl); K14(Dimethyl); 5 2727.305 3.07 mitochondrial M17(Oxidation) Sarcosine N-Term(Dimethyl:2H(6)13C(2)); STVCGPESFTPDHKPLMGEAPELR Q99LB7 dehydrogenase, C4(Carbamidomethyl); 21 2727.395 4.55 mitochondrial K14(HeavyDimethyl) Sarcosine N-Term(Dimethyl:2H(6)13C(2)); STVCGPESFTPDHKPLMGEAPELR Q99LB7 dehydrogenase, C4(Carbamidomethyl); 1 2743.393 3.22 mitochondrial K14(HeavyDimethyl); M17(Oxidation) N-Term(Dimethyl); STVNTAVALTLACFGTQR Q61176 Arginase-1 13 1938.014 5.08 C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); STVNTAVALTLACFGTQR Q61176 Arginase-1 9 1946.058 4.44 C13(Carbamidomethyl) 26S protease regulatory N-Term(Dimethyl); SVCTEAGMFAIR P46471 1 1369.663 2.19 subunit 7 C3(Carbamidomethyl) N-Term(Dimethyl); K17(Dimethyl); SVDEIIRLVQAFQFTDKHGEVCPAGWK P35700 Peroxiredoxin-1 C22(Carbamidomethyl); K27(Dimethyl); 3 4522.411 4.16 PGSDTIKPDVNK K34(Dimethyl); K39(Dimethyl)

Malate dehydrogenase, N-Term(Dimethyl); K3(Dimethyl); SVKVIVVGNPANTNCLTASK P14152 5 2156.208 5.28 cytoplasmic C15(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, K3(HeavyDimethyl); SVKVIVVGNPANTNCLTASK P14152 6 2180.343 4.62 cytoplasmic C15(Carbamidomethyl); K20(HeavyDimethyl) Isoform 2 of Gamma- SVLEQIAAYGQVVFRLQEFIDEVMGHS Q8BKN5-2 tubulin complex M24(Oxidation); K40(HeavyDimethyl) 1 4391.214 3.20 SESLPPGNGPIPK component 5 GTP cyclohydrolase 1 N-Term(Dimethyl); K22(Dimethyl); SVLGNNFYEYYVNDPPRIVLDKLECK P99025 feedback regulatory 1 3229.656 3.04 C25(Carbamidomethyl); K26(Dimethyl) protein N-Term(Dimethyl:2H(6)13C(2)); GTP cyclohydrolase 1 K22(HeavyDimethyl); SVLGNNFYEYYVNDPPRIVLDKLECK P99025 feedback regulatory 1 3253.812 3.06 C25(Carbamidomethyl); protein K26(HeavyDimethyl) Heat shock 70 kDa N-Term(Dimethyl); SVMDATQIAGLNCLR Q61316 3 1676.843 3.73 protein 4 C13(Carbamidomethyl) Heat shock 70 kDa N-Term(Dimethyl:2H(6)13C(2)); SVMDATQIAGLNCLR Q61316 1 1684.886 2.38 protein 4 C13(Carbamidomethyl) SVMQSSGSVTQSLRSVMQSSGSVMQS E9Q6E9 Protein Simc1 N-Term(Dimethyl); M17(Oxidation) 1 3614.733 2.93 PGGVTQSLR 39S ribosomal protein N-Term(Dimethyl); SVPFLPLLGGCVDDTILSR Q3TBW2 1 2087.123 2.61 L10, mitochondrial C11(Carbamidomethyl) SVPMSTVFYPSDGVATEKAVELAANT N-Term(Dimethyl); K18(Dimethyl); P40142 Transketolase 1 3642.890 3.38 KGICFIR K27(Dimethyl); C30(Carbamidomethyl)

N-Term(Dimethyl); SVREHQDSLDPNSPRDFIDCFLTK P33267 Cytochrome P450 2F2 1 2932.432 2.88 C20(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); SVREHQDSLDPNSPRDFIDCFLTK P33267 Cytochrome P450 2F2 C20(Carbamidomethyl); 1 2948.521 2.53 K24(HeavyDimethyl) N-Term(Dimethyl); S-formylglutathione SVSAFAPICNPVLCSWGK H3BJP2 C9(Carbamidomethyl); 3 2049.021 3.20 hydrolase (Fragment) C14(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); S-formylglutathione C9(Carbamidomethyl); SVSAFAPICNPVLCSWGK H3BJP2 2 2065.119 3.28 hydrolase (Fragment) C14(Carbamidomethyl); K18(HeavyDimethyl) N-Term(Dimethyl); S-formylglutathione C9(Carbamidomethyl); SVSAFAPICNPVLCSWGKK H3BJP2 7 2205.143 3.56 hydrolase (Fragment) C14(Carbamidomethyl); K18(Dimethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C9(Carbamidomethyl); S-formylglutathione SVSAFAPICNPVLCSWGKK H3BJP2 C14(Carbamidomethyl); 1 2229.290 2.63 hydrolase (Fragment) K18(HeavyDimethyl); K19(HeavyDimethyl) Acyl-coenzyme A N-Term(Dimethyl:2H(6)13C(2)); SVSEDVHVHSLHCYFVR P58137 1 2107.060 3.31 thioesterase 8 C13(Carbamidomethyl) DNA-directed RNA N-Term(Dimethyl); SVTGGAWYSDQDFESEFVEVLNQQCF Q921X6 polymerase III subunit C25(Carbamidomethyl); K27(Dimethyl); 1 4386.074 3.17 KFLQSKAETAR RPC6 K32(Dimethyl) Isoform 4 of Immunoglobulin-like SVVVSQWQLLQAGSAGSAARPDGSGS Q3KNY0-4 and fibronectin type III K36(Dimethyl) 1 3842.902 3.32 ESLAASSSWKPR domain-containing protein 1 SWDSLTFHSHTVRK A2APL1 Protein 4930404H24Rik N-Term(Dimethyl); K14(Dimethyl) 1 1756.903 2.38 Granulocyte colony- SWMIEPNGNITGILLK P40223 stimulating factor M3(Oxidation); K16(Dimethyl) 1 1829.993 2.37 receptor SWTLADSVSAALAESAEELGSWRKTL Nucleolar pre-ribosomal- Q571H0 N-Term(Dimethyl); K24(Dimethyl) 2 3103.686 2.90 LR associated protein 1

3-hydroxyanthranilate N-Term(Dimethyl); SWVEENRASFQPPVCNK Q78JT3 1 2104.029 2.48 3,4-dioxygenase C15(Carbamidomethyl); K17(Dimethyl) SWVRESEIQARDQNNIENLR D3Z4K0 Protein Ankrd36 2 2457.190 2.75 60S ribosomal protein N-Term(Dimethyl); SYCAEIAHNVSSK P62911 7 1521.732 4.79 L32 C3(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein SYCAEIAHNVSSK P62911 C3(Carbamidomethyl); 4 1537.822 3.94 L32 K13(HeavyDimethyl) LysM and putative peptidoglycan-binding N-Term(Dimethyl:2H(6)13C(2)); SYGSLVQSSCSPVR Q9D0E3 1 1562.794 2.01 domain-containing C10(Carbamidomethyl) protein 1 Glycine dehydrogenase N-Term(Dimethyl); SYIGMGYYNCSVPQTILR Q91W43 (decarboxylating), 4 2150.042 4.21 C10(Carbamidomethyl) mitochondrial

Glycine dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); SYIGMGYYNCSVPQTILR Q91W43 (decarboxylating), 4 2158.079 4.04 C10(Carbamidomethyl) mitochondrial

SYLETFSYSNAEQDDLWRHIQMAIGEQ N-Term(Dimethyl:2H(6)13C(2)); E9QJR0 Protein 4833403I15Rik 1 4380.274 3.30 NVTHLPATVK M22(Oxidation); K37(HeavyDimethyl) K4(HeavyDimethyl); SYWKSQVNHDICRSEPVSAAVLR D3Z3C3 Heparanase 1 2738.387 2.83 C12(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl); TAACLAAGNTVVIKPAQVTPLTALK Q8R0Y6 formyltetrahydrofolate C4(Carbamidomethyl); K14(Dimethyl); 5 2592.514 4.33 dehydrogenase K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytosolic 10- C4(Carbamidomethyl); TAACLAAGNTVVIKPAQVTPLTALK Q8R0Y6 formyltetrahydrofolate 1 2616.644 2.84 K14(HeavyDimethyl); dehydrogenase K25(HeavyDimethyl) Isobutyryl-CoA N-Term(Dimethyl); TAAVALQEEREDAVALCSMAK Q9D7B6 dehydrogenase, 4 2319.169 4.07 C17(Carbamidomethyl); K21(Dimethyl) mitochondrial Acetyl-coenzyme A N-Term(Dimethyl); TACPGPFLQYNFDVTK D6RHA7 2 1913.951 2.42 synthetase, cytoplasmic C3(Carbamidomethyl); K16(Dimethyl) Phenylalanine-4- N-Term(Dimethyl); TACQEYTVTEFQPLYYVAESFNDAK P16331 2 3030.440 4.02 hydroxylase C3(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine-4- TACQEYTVTEFQPLYYVAESFNDAK P16331 C3(Carbamidomethyl); 2 3046.512 4.80 hydroxylase K25(HeavyDimethyl) N-Term(Dimethyl); TACQEYTVTEFQPLYYVAESFNDAKE Phenylalanine-4- P16331 C3(Carbamidomethyl); K25(Dimethyl); 10 3315.585 5.01 K hydroxylase K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TACQEYTVTEFQPLYYVAESFNDAKE Phenylalanine-4- C3(Carbamidomethyl); P16331 7 3339.724 5.52 K hydroxylase K25(HeavyDimethyl); K27(HeavyDimethyl) S-adenosylmethionine N-Term(Dimethyl:2H(6)13C(2)); TACYGHFGR Q91X83 2 1104.543 2.44 synthase isoform type-1 C3(Carbamidomethyl)

S-adenosylmethionine N-Term(Dimethyl); TACYGHFGRSEFPWEVPK Q91X83 12 2224.058 3.74 synthase isoform type-1 C3(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); S-adenosylmethionine TACYGHFGRSEFPWEVPK Q91X83 C3(Carbamidomethyl); 6 2240.150 4.10 synthase isoform type-1 K18(HeavyDimethyl) N-Term(Dimethyl); K6(Dimethyl); TAEEVKSTVNTAVALTLACFGTQR Q61176 Arginase-1 2 2623.387 3.96 C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TAEEVKSTVNTAVALTLACFGTQR Q61176 Arginase-1 K6(HeavyDimethyl); 2 2639.473 4.01 C19(Carbamidomethyl) SWI/SNF-related matrix- associated actin- M4(Oxidation); K7(Dimethyl); TAEMNEKLSKMGESSLR Q91ZW3 dependent regulator of 1 1982.986 2.37 K10(Dimethyl) chromatin subfamily A member 5 TAFDDAIAELDTLNEDSYKDSTLIMQL N-Term(Dimethyl:2H(6)13C(2)); P61982 14-3-3 protein gamma 1 3389.740 3.27 LR K19(HeavyDimethyl); M25(Oxidation) N-Term(Dimethyl); Ubiquitin carboxyl- C5(Carbamidomethyl); TAGLCEGCHEADFEQPCLPADSLLR P52479 1 2874.323 2.78 terminal hydrolase 10 C8(Carbamidomethyl); C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Ubiquitin carboxyl- C5(Carbamidomethyl); TAGLCEGCHEADFEQPCLPADSLLR P52479 1 2882.331 2.67 terminal hydrolase 10 C8(Carbamidomethyl); C17(Carbamidomethyl) Hydroxysteroid N-Term(Dimethyl); TAIHTAAMDMLGGSGVENQCR B1AX77 dehydrogenase-like 2 2247.030 3.85 C20(Carbamidomethyl) protein 2 (Fragment) Hydroxysteroid N-Term(Dimethyl:2H(6)13C(2)); TAIHTAAMDMLGGSGVENQCR B1AX77 dehydrogenase-like 2 2255.072 5.72 C20(Carbamidomethyl) protein 2 (Fragment) Ornithine N-Term(Dimethyl); K3(Dimethyl); TAKVAASDWTFLHCLPR Q8R1A8 carbamoyltransferase, 5 2029.073 4.95 C14(Carbamidomethyl) mitochondrial Ornithine N-Term(Dimethyl:2H(6)13C(2)); TAKVAASDWTFLHCLPR Q8R1A8 carbamoyltransferase, K3(HeavyDimethyl); 6 2045.154 3.60 mitochondrial C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Ornithine TAKVAASDWTFLHCLPRKPEEVDDEV K3(HeavyDimethyl); Q8R1A8 carbamoyltransferase, 1 3772.018 2.98 FYSPR C14(Carbamidomethyl); mitochondrial K18(HeavyDimethyl) Isoform 2 of AF4/FMR2 TALRALADSSVVQQTNCR P51827-2 C17(Carbamidomethyl) 1 1989.996 2.45 family member 3 Acyl-coenzyme A synthetase ACSM1, N-Term(Dimethyl); TANVFEQICGLQQGDHLALILPR D3Z106 1 2621.393 2.98 mitochondrial C9(Carbamidomethyl) (Fragment) Acyl-coenzyme A synthetase ACSM1, N-Term(Dimethyl:2H(6)13C(2)); TANVFEQICGLQQGDHLALILPR D3Z106 3 2629.435 4.02 mitochondrial C9(Carbamidomethyl) (Fragment) DNA (cytosine-5)- TAPARVPALASPAGSLPDHVR P13864 N-Term(Dimethyl) 1 2111.176 2.43 methyltransferase 1 N-Term(Dimethyl); TATECASKPGTTQDSAGPSKVK Q99K95 Protein RTF2 homolog C5(Carbamidomethyl); K8(Dimethyl); 1 2333.205 2.59 K20(Dimethyl); K22(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl); K17(Dimethyl); TAVDSGIALLTNFQVTKLFAEAVQK Q8C196 synthase [ammonia], 6 2748.550 5.18 K25(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); TAVDSGIALLTNFQVTKLFAEAVQK Q8C196 synthase [ammonia], K17(HeavyDimethyl); 5 2772.682 4.07 mitochondrial K25(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); K17(Dimethyl); TAVDSGIALLTNFQVTKLFAEAVQKSR Q8C196 synthase [ammonia], 1 2991.710 3.15 K25(Dimethyl) mitochondrial TAVLDASGVPVCTNSSTQNLDLGSFEK E0CXG4 Protein GREB1 C12(Carbamidomethyl); K27(Dimethyl) 1 2838.369 2.66

Oxygen-dependent N-Term(Dimethyl); TCAEAVVPSYVPIVK P36552 coproporphyrinogen-III 1 1688.924 3.37 C2(Carbamidomethyl); K15(Dimethyl) oxidase, mitochondrial

Oxygen-dependent N-Term(Dimethyl); TCAEAVVPSYVPIVKK P36552 coproporphyrinogen-III C2(Carbamidomethyl); K15(Dimethyl); 1 1845.053 3.01 oxidase, mitochondrial K16(Dimethyl) Staphylococcal nuclease N-Term(Dimethyl); TCATVTIGGINIAEALVSKGLATVIR Q3TJ56 domain-containing 3 2684.550 3.38 C2(Carbamidomethyl); K19(Dimethyl) protein 1 Electron transfer TCDIKDPSQNINWVVPEGGGGPAYNG flavoprotein-ubiquinone N-Term(Dimethyl); Q6PF96 1 2932.360 3.80 M oxidoreductase, C2(Carbamidomethyl); K5(Dimethyl) mitochondrial Electron transfer N-Term(Dimethyl:2H(6)13C(2)); TCDIKDPSQNINWVVPEGGGGPAYNG flavoprotein-ubiquinone Q6PF96 C2(Carbamidomethyl); 1 2948.459 3.25 M oxidoreductase, K5(HeavyDimethyl) mitochondrial N-Term(Dimethyl); TCEDWVDGISQFK Q8R164 Valacyclovir hydrolase 1 1640.756 2.43 C2(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl); TCEDWVDGISQFKQLPEGNICR Q8R164 Valacyclovir hydrolase C2(Carbamidomethyl); K13(Dimethyl); 1 2708.272 2.94 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); TCEDWVDGISQFKQLPEGNICR Q8R164 Valacyclovir hydrolase 1 2724.385 3.14 K13(HeavyDimethyl); C21(Carbamidomethyl) N-Term(Dimethyl); TCLLNETGDEPFQYK P15105 Glutamine synthetase 6 1870.885 4.47 C2(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TCLLNETGDEPFQYK P15105 Glutamine synthetase C2(Carbamidomethyl); 1 1886.973 3.98 K15(HeavyDimethyl) TCLLNETGDEPFQYKN P15105 Glutamine synthetase C2(Carbamidomethyl); K15(Dimethyl) 6 1956.907 4.41 C2(Carbamidomethyl); TCLLNETGDEPFQYKN P15105 Glutamine synthetase 9 1964.942 4.24 K15(HeavyDimethyl) N-Term(Dimethyl); TCLLNETGDEPFQYKN P15105 Glutamine synthetase 7 1984.928 5.44 C2(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TCLLNETGDEPFQYKN P15105 Glutamine synthetase C2(Carbamidomethyl); 20 2001.019 5.92 K15(HeavyDimethyl) Transient receptor C2(Carbamidomethyl); TCLPKALLNLSNGR D3Z1H6 potential cation channel 1 1592.911 2.13 K5(HeavyDimethyl) subfamily V member 4 N-Term(Dimethyl); TCMQFSIRRPK A2ABG4 Protein Tbc1d16 1 1479.800 2.06 C2(Carbamidomethyl); K11(Dimethyl) tRNA (guanine-N(7)-)- N-Term(Dimethyl); TCPEAAGGPMASSAGLALCAQTLVVR E9Q1H7 methyltransferase non- C2(Carbamidomethyl); M10(Oxidation); 1 2632.268 2.33 catalytic subunit WDR4 C19(Carbamidomethyl) N-Term(Dimethyl); Homogentisate 1,2- TCSCLDENYYK O09173 C2(Carbamidomethyl); 2 1508.634 2.38 dioxygenase C4(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Trinucleotide repeat- TCSSQPQPAGTSPSTSTSTISSGSNGKR C2(Carbamidomethyl); B1ATC3 containing gene 6C 1 4025.010 2.82 ASACGQQPAASR K27(HeavyDimethyl); protein C32(Carbamidomethyl) C2(Carbamidomethyl); K15(Dimethyl); TCTTVAFTQVNSEDKGALAK D3YXT4 Uncharacterized protein 1 2197.123 3.01 K20(Dimethyl) C2(Carbamidomethyl); TCTTVAFTQVNSEDKGALAK D3YXT4 Uncharacterized protein K15(HeavyDimethyl); 1 2213.224 2.36 K20(HeavyDimethyl) N-Term(Dimethyl); TCTTVAFTQVNSEDKGALAK D3YXT4 Uncharacterized protein C2(Carbamidomethyl); K15(Dimethyl); 2 2225.148 4.39 K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); TCTTVAFTQVNSEDKGALAK D3YXT4 Uncharacterized protein 2 2249.275 3.84 K15(HeavyDimethyl); K20(HeavyDimethyl) C2(Carbamidomethyl); TCVADESAANCDK P07724 Serum albumin 2 1468.602 3.26 C11(Carbamidomethyl); K13(Dimethyl) C2(Carbamidomethyl); TCVADESAANCDK P07724 Serum albumin C11(Carbamidomethyl); 3 1476.646 3.32 K13(HeavyDimethyl) N-Term(Dimethyl); TCVADESAANCDK P07724 Serum albumin C2(Carbamidomethyl); 5 1496.629 3.62 C11(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); TCVADESAANCDK P07724 Serum albumin 3 1512.721 3.77 C11(Carbamidomethyl); K13(HeavyDimethyl) Isoform 2 of Rab GDP C9(Carbamidomethyl); TDDYLDQPCCETINR Q61598-2 dissociation inhibitor 12 1899.775 3.14 C10(Carbamidomethyl) beta Isoform 2 of Rab GDP N-Term(Dimethyl); TDDYLDQPCCETINR Q61598-2 dissociation inhibitor C9(Carbamidomethyl); 6 1927.811 3.70 beta C10(Carbamidomethyl) Isoform 2 of Rab GDP N-Term(Dimethyl:2H(6)13C(2)); TDDYLDQPCCETINR Q61598-2 dissociation inhibitor C9(Carbamidomethyl); 11 1935.861 3.93 beta C10(Carbamidomethyl) TDFLEATGLDLLHLGNNRISMIQDRAF Isoform 2 of SLIT and Q810B7-2 M21(Oxidation) 2 3801.970 3.51 GDLGNLR NTRK-like protein 5 Dehydrogenase/reductas N-Term(Dimethyl); K8(Dimethyl); TDFSLREKTMPNMLPDMNK Q149L0 1 2352.195 2.32 e member 2 K19(Dimethyl) Bifunctional heparan TDPTVLLFVESQYSQLGQDIIAILESSR D3YWZ6 sulfate N-deacetylase/N- 1 3122.671 2.46 sulfotransferase 4 N-Term(Dimethyl); TEERLAYGIESNSTLLECTPR P70275 Semaphorin-3E 1 2467.186 2.77 C18(Carbamidomethyl) TEFSFTDYNTKENVLAVLANIRYMSG Q62507 Cochlin K11(HeavyDimethyl); M24(Oxidation) 1 4296.203 3.29 GTATGDAIAFTVR K10(Dimethyl); M17(Oxidation); TEGGTTVTVKDDQVYPMNPPK Q1WNQ6 Myosin-1 (Fragment) 1 2349.199 2.87 K21(Dimethyl) K10(HeavyDimethyl); M17(Oxidation); TEGGTTVTVKDDQVYPMNPPK Q1WNQ6 Myosin-1 (Fragment) 1 2365.283 2.88 K21(HeavyDimethyl) Small ubiquitin-related K10(HeavyDimethyl); TENNDHINLKVAGQDGSVVQFK H7BWX9 1 2485.369 2.66 modifier 2 K22(HeavyDimethyl) Hydroxyacyl-coenzyme N-Term(Dimethyl); TFESLVDFCK Q61425 A dehydrogenase, 4 1301.642 2.79 C9(Carbamidomethyl); K10(Dimethyl) mitochondrial

Hydroxyacyl-coenzyme N-Term(Dimethyl:2H(6)13C(2)); TFESLVDFCK Q61425 A dehydrogenase, C9(Carbamidomethyl); 1 1317.731 2.23 mitochondrial K10(HeavyDimethyl) N-Term(Dimethyl); TFLLDGDEVIITGHCQGDGYR P35505 Fumarylacetoacetase 9 2394.129 4.17 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TFLLDGDEVIITGHCQGDGYR P35505 Fumarylacetoacetase 3 2402.190 4.24 C15(Carbamidomethyl) N-Term(Dimethyl); TFLLDGDEVIITGHCQGDGYRVGFGQC P35505 Fumarylacetoacetase C15(Carbamidomethyl); 1 3326.596 3.66 AGK C27(Carbamidomethyl); K30(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TFLLDGDEVIITGHCQGDGYRVGFGQC C15(Carbamidomethyl); P35505 Fumarylacetoacetase 1 3342.679 3.03 AGK C27(Carbamidomethyl); K30(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); TFLLDGDEVIITGHCQGDGYRVGFGQC C15(Carbamidomethyl); P35505 Fumarylacetoacetase 2 4091.159 4.29 AGKVLPALSPA C27(Carbamidomethyl); K30(HeavyDimethyl) Aldehyde N-Term(Dimethyl); TFPTVNPSTGEVICQVAEGNKEDVDKA P47738 dehydrogenase, C14(Carbamidomethyl); K21(Dimethyl); 1 3244.681 3.18 VK mitochondrial K26(Dimethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aldehyde C14(Carbamidomethyl); TFPTVNPSTGEVICQVAEGNKEDVDKA P47738 dehydrogenase, K21(HeavyDimethyl); 2 3276.855 4.60 VK mitochondrial K26(HeavyDimethyl); K29(HeavyDimethyl) Enoyl-CoA hydratase, N-Term(Dimethyl:2H(6)13C(2)); TFQDCYSSK F6T930 mitochondrial C5(Carbamidomethyl); 1 1207.625 2.12 (Fragment) K9(HeavyDimethyl) Enoyl-CoA hydratase, N-Term(Dimethyl:2H(6)13C(2)); TFQDCYSSKFLSHWDHITR F6T930 mitochondrial C5(Carbamidomethyl); 1 2500.264 3.17 (Fragment) K9(HeavyDimethyl) 6- N-Term(Dimethyl); TGALCWFLDEAAAR D3Z4X1 phosphogluconolactonas 1 1608.783 3.86 C5(Carbamidomethyl) e 6- N-Term(Dimethyl:2H(6)13C(2)); TGALCWFLDEAAAR D3Z4X1 phosphogluconolactonas 1 1616.828 2.89 C5(Carbamidomethyl) e Isoform Short of C3(Carbamidomethyl); TGCTFPEKPDFH P55264-2 3 1471.703 2.31 Adenosine kinase K8(HeavyDimethyl) Isoform Short of N-Term(Dimethyl); TGCTFPEKPDFH P55264-2 17 1491.690 3.30 Adenosine kinase C3(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Short of TGCTFPEKPDFH P55264-2 C3(Carbamidomethyl); 10 1507.775 3.18 Adenosine kinase K8(HeavyDimethyl) Acyl-CoA synthetase C13(Carbamidomethyl); TGDIALMDEQGFCK Q8VCW8 family member 2, 2 1620.779 2.33 K14(HeavyDimethyl) mitochondrial Acyl-CoA synthetase N-Term(Dimethyl); TGDIALMDEQGFCK Q8VCW8 family member 2, 2 1640.762 3.22 C13(Carbamidomethyl); K14(Dimethyl) mitochondrial Acyl-CoA synthetase N-Term(Dimethyl); M7(Oxidation); TGDIALMDEQGFCK Q8VCW8 family member 2, 1 1656.754 2.22 C13(Carbamidomethyl); K14(Dimethyl) mitochondrial Acyl-CoA synthetase N-Term(Dimethyl:2H(6)13C(2)); TGDIALMDEQGFCK Q8VCW8 family member 2, C13(Carbamidomethyl); 8 1656.846 4.07 mitochondrial K14(HeavyDimethyl) Acyl-CoA synthetase N-Term(Dimethyl); TGDIALMDEQGFCKIVGR Q8VCW8 family member 2, 5 2066.036 3.31 C13(Carbamidomethyl); K14(Dimethyl) mitochondrial Acyl-CoA synthetase N-Term(Dimethyl:2H(6)13C(2)); TGDIALMDEQGFCKIVGR Q8VCW8 family member 2, C13(Carbamidomethyl); 3 2082.136 3.03 mitochondrial K14(HeavyDimethyl) Ral GTPase-activating C22(Carbamidomethyl); TGEEILPAYLSSVILNSPPLFCCDLK A2ACC7 protein subunit beta 1 2964.525 2.32 C23(Carbamidomethyl); K26(Dimethyl) (Fragment) TGEIQFSREFDMKSK Q7TMD7 Desmoglein-4 K13(Dimethyl); K15(Dimethyl) 1 1858.936 2.32 Ester hydrolase TGELNFVSCMR Q91V76 C9(Carbamidomethyl) 1 1313.603 2.23 C11orf54 homolog Ester hydrolase N-Term(Dimethyl); TGELNFVSCMR Q91V76 2 1341.620 2.45 C11orf54 homolog C9(Carbamidomethyl) Ester hydrolase N-Term(Dimethyl:2H(6)13C(2)); TGELNFVSCMR Q91V76 3 1349.663 2.39 C11orf54 homolog C9(Carbamidomethyl) C19(Carbamidomethyl); TGGTYGEDLGADYNLSQVCDGK P19096 Fatty acid synthase 1 2356.046 2.47 K22(HeavyDimethyl) N-Term(Dimethyl); TGGTYGEDLGADYNLSQVCDGK P19096 Fatty acid synthase 1 2376.070 4.67 C19(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TGGTYGEDLGADYNLSQVCDGK P19096 Fatty acid synthase C19(Carbamidomethyl); 2 2392.132 4.65 K22(HeavyDimethyl) Sarcosine TGIKSTVCGPESFTPDHKPLMGEAPEL N-Term(Dimethyl); K4(Dimethyl); Q99LB7 dehydrogenase, 1 3138.604 3.25 R C8(Carbamidomethyl); K18(Dimethyl) mitochondrial N-Term(Dimethyl); 17-beta-hydroxysteroid TGIQTSCLCPVFVNTGFTK A8Y5N4 C7(Carbamidomethyl); 3 2186.067 2.72 dehydrogenase 13 C9(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 17-beta-hydroxysteroid C7(Carbamidomethyl); TGIQTSCLCPVFVNTGFTK A8Y5N4 1 2202.156 2.94 dehydrogenase 13 C9(Carbamidomethyl); K19(HeavyDimethyl) Isoform 2 of Histone- TGLQKGSADRGAQGSVR Q6P2L6-2 lysine N- K5(Dimethyl) 1 1715.896 2.42 methyltransferase NSD3 Superoxide dismutase N-Term(Dimethyl); TGNAGSRLACGVIGIAQ P08228 1 1672.873 2.41 [Cu-Zn] C10(Carbamidomethyl) Bifunctional TGNKYNVYPTYDFACPIVDSIEGVTHA N-Term(Dimethyl); K4(Dimethyl); Q8CGC7 glutamate/proline--tRNA 1 3356.694 3.13 LR C15(Carbamidomethyl) ligase Bifunctional N-Term(Dimethyl:2H(6)13C(2)); TGNKYNVYPTYDFACPIVDSIEGVTHA Q8CGC7 glutamate/proline--tRNA K4(HeavyDimethyl); 2 3372.789 3.26 LR ligase C15(Carbamidomethyl) N-Term(Dimethyl); Phosphoglycerate kinase TGQATVASGIPAGWMGLDCGTESSKK P09411 C19(Carbamidomethyl); K25(Dimethyl); 3 2693.331 3.38 1 K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phosphoglycerate kinase C19(Carbamidomethyl); TGQATVASGIPAGWMGLDCGTESSKK P09411 2 2717.462 3.26 1 K25(HeavyDimethyl); K26(HeavyDimethyl) N-Term(Dimethyl); TGQATVASGIPAGWMGLDCGTESSKK Phosphoglycerate kinase P09411 C19(Carbamidomethyl); K25(Dimethyl); 1 3439.704 3.15 YAEAVGR 1 K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TGQATVASGIPAGWMGLDCGTESSKK Phosphoglycerate kinase C19(Carbamidomethyl); P09411 1 3463.818 3.14 YAEAVGR 1 K25(HeavyDimethyl); K26(HeavyDimethyl) TGRFEEASTMPCRLALSPDTHVLALAT Transducin beta-like N-Term(Dimethyl); Q9R099 1 4126.073 3.44 GTNIHLFNTR protein 2 C12(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); TGSKVEDNSCTMVPGGGSR Q91ZU6 Dystonin 1 2010.942 2.62 C10(Carbamidomethyl); M12(Oxidation) 40S ribosomal protein N-Term(Dimethyl); TGSQGQCTQVRVEFMDDTSR G3UYV7 2 2330.048 2.54 S28 (Fragment) C7(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); TGSQGQCTQVRVEFMDDTSR G3UYV7 2 2338.097 2.56 S28 (Fragment) C7(Carbamidomethyl) TGTLIQGHEPEAGEAQLGEMR Q7TSH3 Zinc finger protein 516 N-Term(Dimethyl) 1 2252.125 2.38 Isoform 2 of Probable N-Term(Dimethyl); phospholipid- TGTLTENSMEFIECCIDGHK Q9QZW0-2 C14(Carbamidomethyl); 1 2398.075 3.02 transporting ATPase C15(Carbamidomethyl); K20(Dimethyl) 11C 60S ribosomal protein N-Term(Dimethyl); TGVHHYSGNNIELGTACGK P62889 2 2070.992 3.31 L30 C17(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein TGVHHYSGNNIELGTACGK P62889 C17(Carbamidomethyl); 1 2087.088 3.36 L30 K19(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); TGVHHYSGNNIELGTACGKYYR P62889 1 2553.222 2.95 L30 C17(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein TGVHHYSGNNIELGTACGKYYR P62889 C17(Carbamidomethyl); 1 2569.306 2.85 L30 K19(HeavyDimethyl) Epoxide hydrolase 1 N-Term(Dimethyl); THGLSDEHVFEVICPSIPGYGFSEASSK F6YTS6 3 3106.493 3.29 (Fragment) C14(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Epoxide hydrolase 1 THGLSDEHVFEVICPSIPGYGFSEASSK F6YTS6 C14(Carbamidomethyl); 1 3122.568 3.68 (Fragment) K28(HeavyDimethyl) N-Term(Dimethyl); THHQAVNFNIFEGMVCHGVPLVTISR Q9EQF5 Dihydropyrimidinase 3 2991.521 3.39 C16(Carbamidomethyl) THIFGADGARKLAQTLDLDVLGDVPL Iron-sulfur protein Q9CWD8 K11(HeavyDimethyl) 1 3377.871 3.02 HLSIR NUBPL N-Term(Dimethyl:2H(6)13C(2)); THTGERPYLCSNCGRRFSQSSHLLTHM C10(Carbamidomethyl); Q6PGE4 Zinc finger protein 316 1 3448.703 2.78 K C13(Carbamidomethyl); M27(Oxidation); K28(HeavyDimethyl)

N-Term(Dimethyl); THYWLIVSCSIAYVAVVSLLIWVPVKV Transmembrane protein A2ARJ3 C9(Carbamidomethyl); K26(Dimethyl); 1 3859.252 3.03 VLYKK 236 K31(Dimethyl); K32(Dimethyl) N-Term(Dimethyl); TIAACNLPIVQGPCR Q07456 Protein AMBP C5(Carbamidomethyl); 4 1697.875 4.06 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TIAACNLPIVQGPCR Q07456 Protein AMBP C5(Carbamidomethyl); 4 1705.928 3.78 C14(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); TIAECLADELINAAK D3YYM6 9 1687.885 4.09 S5 (Fragment) C5(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein TIAECLADELINAAK D3YYM6 C5(Carbamidomethyl); 1 1703.976 2.47 S5 (Fragment) K15(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); TICSHVQNMIK D3Z629 1 1386.725 2.17 L9 C3(Carbamidomethyl); K11(Dimethyl) TIEDTPLSHHYYDNMLPKHGFHQMPK Alpha-2,8- N-Term(Dimethyl); K18(Dimethyl); Q8K4T1 1 4653.208 3.29 EYSQMLQLHMR sialyltransferase 8F M24(Oxidation); K26(Dimethyl) N-Term(Dimethyl); TIEEYAICPDLK Q9D0F9 Phosphoglucomutase-1 3 1507.767 2.69 C8(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TIEEYAICPDLK Q9D0F9 Phosphoglucomutase-1 C8(Carbamidomethyl); 1 1523.859 2.65 K12(HeavyDimethyl) N-Term(Dimethyl); TIEEYAICPDLKVDLGVLGK Q9D0F9 Phosphoglucomutase-1 C8(Carbamidomethyl); K12(Dimethyl); 2 2317.273 3.31 K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C8(Carbamidomethyl); TIEEYAICPDLKVDLGVLGK Q9D0F9 Phosphoglucomutase-1 1 2341.400 3.33 K12(HeavyDimethyl); K20(HeavyDimethyl) N-Term(Dimethyl); TIGGGDDSFTTFFCETGAGK P68368 Tubulin alpha-4A chain 1 2123.970 3.08 C14(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TIGGGDDSFTTFFCETGAGK P68368 Tubulin alpha-4A chain C14(Carbamidomethyl); 1 2140.044 2.37 K20(HeavyDimethyl) K19(HeavyDimethyl); TIGSTYMAASGLNDSTYDKAGK P84309 Adenylate cyclase type 5 1 2323.173 2.33 K22(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); TIHNQEFDPTNLLQCWEACVENSSYY G3X982 Aldehyde oxidase 3 C15(Carbamidomethyl); 1 3524.609 3.42 NR C19(Carbamidomethyl) Malate dehydrogenase, N-Term(Dimethyl); TIIPLISQCTPK P08249 9 1426.825 3.03 mitochondrial C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, TIIPLISQCTPK P08249 C9(Carbamidomethyl); 12 1442.924 2.94 mitochondrial K12(HeavyDimethyl) Malate dehydrogenase, N-Term(Dimethyl); TIIPLISQCTPKVDFPQDQLATLTGR P08249 10 2968.622 4.31 mitochondrial C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, TIIPLISQCTPKVDFPQDQLATLTGR P08249 C9(Carbamidomethyl); 8 2984.708 4.12 mitochondrial K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Guanine nucleotide- K3(HeavyDimethyl); TIKLWNTLGVCK P68040 binding protein subunit 1 1541.026 2.31 C11(Carbamidomethyl); beta-2-like 1 K12(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); TILNNGKTCR P16015 Carbonic anhydrase 3 1 1232.674 2.37 C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TILNNGKTCRVVFDDTYDR P16015 Carbonic anhydrase 3 K7(HeavyDimethyl); 3 2359.261 2.73 C9(Carbamidomethyl) Aldehyde N-Term(Dimethyl:2H(6)13C(2)); TIPIDGDFFSYTRHEPVGVCGQIIPWNF P47738 dehydrogenase, C20(Carbamidomethyl); 2 4305.278 3.55 PLLMQAWK mitochondrial K36(HeavyDimethyl) TIQFINPAGDLVNMNQNLRQDVEYDV M30(Oxidation); K34(HeavyDimethyl); K7N702 Protein Vmn2r70 1 4727.434 2.94 FYIMDFQKVYGLK K39(HeavyDimethyl) N-Term(Dimethyl); TIQFVDWCPTGFK P05214 Tubulin alpha-3 chain 2 1654.831 2.41 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TIQFVDWCPTGFK P05214 Tubulin alpha-3 chain C8(Carbamidomethyl); 2 1670.921 2.93 K13(HeavyDimethyl) D-beta-hydroxybutyrate N-Term(Dimethyl); TIQLNVCNSEEVEK Q80XN0 dehydrogenase, 1 1718.859 2.43 C7(Carbamidomethyl); K14(Dimethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); TIQLNVCNSEEVEK Q80XN0 dehydrogenase, C7(Carbamidomethyl); 1 1734.950 2.38 mitochondrial K14(HeavyDimethyl) D-beta-hydroxybutyrate N-Term(Dimethyl); TIQLNVCNSEEVEKAVETIR Q80XN0 dehydrogenase, 2 2388.248 3.72 C7(Carbamidomethyl); K14(Dimethyl) mitochondrial

D-beta-hydroxybutyrate N-Term(Dimethyl:2H(6)13C(2)); TIQLNVCNSEEVEKAVETIR Q80XN0 dehydrogenase, C7(Carbamidomethyl); 5 2404.331 3.32 mitochondrial K14(HeavyDimethyl)

TIQVDNTDAEGRLILADALCYAHTFNP Isoform 2 of Cytosol N-Term(Dimethyl); Q9CPY7-2 1 3202.628 4.03 K aminopeptidase C20(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TIQVDNTDAEGRLILADALCYAHTFNP Isoform 2 of Cytosol Q9CPY7-2 C20(Carbamidomethyl); 3 3218.714 3.66 K aminopeptidase K28(HeavyDimethyl) RAB3D, member RAS TITTAYYRGAMGFLLMYDIANQESFTA N-Term(Dimethyl:2H(6)13C(2)); D3YW33 oncogene family, 1 4656.375 2.76 VQDWATQRNPVLK K40(HeavyDimethyl) isoform CRA_b Isoform 2 of 2- N-Term(Dimethyl:2H(6)13C(2)); oxoisovalerate TIVPWDVDTVCK Q6P3A8-2 C11(Carbamidomethyl); 1 1504.866 2.04 dehydrogenase subunit K12(HeavyDimethyl) beta, mitochondrial Electron transfer TIYAGNALCTVK Q99LC5 flavoprotein subunit C9(Carbamidomethyl); K12(Dimethyl) 3 1338.704 2.38 alpha, mitochondrial Electron transfer N-Term(Dimethyl); TIYAGNALCTVK Q99LC5 flavoprotein subunit 16 1366.737 3.46 C9(Carbamidomethyl); K12(Dimethyl) alpha, mitochondrial Electron transfer N-Term(Dimethyl:2H(6)13C(2)); TIYAGNALCTVK Q99LC5 flavoprotein subunit C9(Carbamidomethyl); 8 1382.824 3.41 alpha, mitochondrial K12(HeavyDimethyl) Electron transfer C9(Carbamidomethyl); K12(Dimethyl); TIYAGNALCTVKCDEK Q99LC5 flavoprotein subunit 1 1898.922 2.79 C13(Carbamidomethyl); K16(Dimethyl) alpha, mitochondrial C9(Carbamidomethyl); Electron transfer K12(HeavyDimethyl); TIYAGNALCTVKCDEK Q99LC5 flavoprotein subunit 1 1915.052 2.33 C13(Carbamidomethyl); alpha, mitochondrial K16(HeavyDimethyl) Electron transfer N-Term(Dimethyl); TIYAGNALCTVKCDEK Q99LC5 flavoprotein subunit C9(Carbamidomethyl); K12(Dimethyl); 17 1926.958 4.40 alpha, mitochondrial C13(Carbamidomethyl); K16(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Electron transfer C9(Carbamidomethyl); TIYAGNALCTVKCDEK Q99LC5 flavoprotein subunit K12(HeavyDimethyl); 3 1951.097 3.99 alpha, mitochondrial C13(Carbamidomethyl); K16(HeavyDimethyl) Electron transfer C9(Carbamidomethyl); K12(Dimethyl); TIYAGNALCTVKCDEKVK Q99LC5 flavoprotein subunit C13(Carbamidomethyl); K16(Dimethyl); 3 2154.125 3.15 alpha, mitochondrial K18(Dimethyl) C9(Carbamidomethyl); Electron transfer K12(HeavyDimethyl); TIYAGNALCTVKCDEKVK Q99LC5 flavoprotein subunit C13(Carbamidomethyl); 2 2178.260 3.33 alpha, mitochondrial K16(HeavyDimethyl); K18(HeavyDimethyl) N-Term(Dimethyl); Electron transfer C9(Carbamidomethyl); K12(Dimethyl); TIYAGNALCTVKCDEKVK Q99LC5 flavoprotein subunit 16 2182.159 4.26 C13(Carbamidomethyl); K16(Dimethyl); alpha, mitochondrial K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C9(Carbamidomethyl); Electron transfer K12(HeavyDimethyl); TIYAGNALCTVKCDEKVK Q99LC5 flavoprotein subunit 8 2214.333 4.31 C13(Carbamidomethyl); alpha, mitochondrial K16(HeavyDimethyl); K18(HeavyDimethyl)

N-Term(Dimethyl); K2(Dimethyl); C3(Carbamidomethyl); K13(Dimethyl); TKCDEWSIISEGKIECESAETTEDCIEK Q921I1 Serotransferrin 1 3459.591 3.02 C16(Carbamidomethyl); C25(Carbamidomethyl); K28(Dimethyl)

Sorting and assembly N-Term(Dimethyl); K2(Dimethyl); TKDDIIICEIGEVFKAK Q8BGH2 machinery component C8(Carbamidomethyl); K15(Dimethyl); 1 2091.194 2.73 50 homolog K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sorting and assembly K2(HeavyDimethyl); TKDDIIICEIGEVFKAK Q8BGH2 machinery component C8(Carbamidomethyl); 3 2123.362 3.10 50 homolog K15(HeavyDimethyl); K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); TLDCEPK P15105 Glutamine synthetase C4(Carbamidomethyl); 1 934.548 2.31 K7(HeavyDimethyl) TLDRSGDLGDMEPLK D3Z2H7 Catenin delta-1 N-Term(Dimethyl); K15(Dimethyl) 1 1702.846 2.30 NADP-dependent malic TLFPGQGNNSYVFPGVALGVVACGLR P06801 C23(Carbamidomethyl) 1 2693.396 2.63 enzyme NADP-dependent malic N-Term(Dimethyl); TLFPGQGNNSYVFPGVALGVVACGLR P06801 4 2721.434 4.85 enzyme C23(Carbamidomethyl) NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); TLFPGQGNNSYVFPGVALGVVACGLR P06801 9 2729.469 4.93 enzyme C23(Carbamidomethyl) TLGAMAIMLVVMGTVIFLSFILR G3UXW8 Thyroid peroxidase N-Term(Dimethyl:2H(6)13C(2)) 1 2532.519 2.41 N-Term(Dimethyl:2H(6)13C(2)); Hydroxyacyl-coenzyme K4(HeavyDimethyl); TLGKHPVSCKDTPGFIVNR Q61425 A dehydrogenase, 1 2234.342 2.32 C9(Carbamidomethyl); mitochondrial K10(HeavyDimethyl) T-complex protein 1 N-Term(Dimethyl); TLIQNCGASTIR E9Q133 6 1361.712 3.15 subunit gamma C6(Carbamidomethyl) T-complex protein 1 N-Term(Dimethyl:2H(6)13C(2)); TLIQNCGASTIR E9Q133 3 1369.761 2.27 subunit gamma C6(Carbamidomethyl) Oxygen-dependent N-Term(Dimethyl); K3(Dimethyl); TLKEACDQHGPDIYPK P36552 coproporphyrinogen-III 1 1955.986 2.69 C6(Carbamidomethyl); K16(Dimethyl) oxidase, mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Oxygen-dependent K3(HeavyDimethyl); TLKEACDQHGPDIYPK P36552 coproporphyrinogen-III 2 1980.127 2.61 C6(Carbamidomethyl); oxidase, mitochondrial K16(HeavyDimethyl) Sarcosine TLKEEAQGASVVPQGPSQPLPSTANVV N-Term(Dimethyl); K3(Dimethyl); Q99LB7 dehydrogenase, 1 4543.426 3.87 VIGGGSLGCQTLYHLAK C36(Carbamidomethyl); K44(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Sarcosine TLKEEAQGASVVPQGPSQPLPSTANVV K3(HeavyDimethyl); Q99LB7 dehydrogenase, 1 4567.554 4.50 VIGGGSLGCQTLYHLAK C36(Carbamidomethyl); mitochondrial K44(HeavyDimethyl) TLLAGQPELLRALVDLAVAPAPAPSR Q8C3I8 Protein FAM203A N-Term(Dimethyl:2H(6)13C(2)) 2 2675.605 2.82 Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TLNEADCATVPPAIR Q8K2B3 [ubiquinone] 1 1663.881 2.23 C7(Carbamidomethyl) flavoprotein subunit, mitochondrial N-Term(Dimethyl:2H(6)13C(2)); TLNTTIEEMEAVSKAGLGMLKFVEAV Protein Dnah10 K14(HeavyDimethyl); M19(Oxidation); F7ABZ6 1 3934.035 3.08 MGYCDVFR (Fragment) K21(HeavyDimethyl); C30(Carbamidomethyl) TLPGMARPIQVKPADSESR D3Z580 Protein Celf5 M5(Oxidation); K12(HeavyDimethyl) 1 2105.148 2.35 N-Term(Dimethyl:2H(6)13C(2)); TLQPNGLLFYYTSGSDVFSISLDNGTV M29(Oxidation); K32(HeavyDimethyl); P97927 Laminin subunit alpha-4 1 4600.517 3.62 VMDVKGIKVMSTDK K35(HeavyDimethyl); K41(HeavyDimethyl)

N-Term(Dimethyl); Vitamin D-binding C5(Carbamidomethyl); TLRECCDTQDSVACFSTQSPLLKR P21614 2 2928.414 2.77 protein C6(Carbamidomethyl); C14(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); Vitamin D-binding TLRECCDTQDSVACFSTQSPLLKR P21614 C6(Carbamidomethyl); 1 2944.491 2.44 protein C14(Carbamidomethyl); K23(HeavyDimethyl) Cytoplasmic dynein 2 M14(Oxidation); K18(HeavyDimethyl); TLRFVAHYYGASLMFTSKSEALLLK Q8K0T2 light intermediate chain 1 2934.686 2.52 K25(HeavyDimethyl) 1 Hydroxyacyl-coenzyme TLSCLSTSTDAASVVHSTDLVVEAIVE N-Term(Dimethyl); Q61425 A dehydrogenase, 2 3215.687 4.08 NLK C4(Carbamidomethyl); K30(Dimethyl) mitochondrial

Hydroxyacyl-coenzyme N-Term(Dimethyl:2H(6)13C(2)); TLSCLSTSTDAASVVHSTDLVVEAIVE Q61425 A dehydrogenase, C4(Carbamidomethyl); 1 3231.767 5.05 NLK mitochondrial K30(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Hydroxyacyl-coenzyme TLSCLSTSTDAASVVHSTDLVVEAIVE C4(Carbamidomethyl); Q61425 A dehydrogenase, 1 3509.023 3.68 NLKLK K30(HeavyDimethyl); mitochondrial K32(HeavyDimethyl) Hydroxyacyl-coenzyme N-Term(Dimethyl); TLSCLSTSTDAASVVHSTDLVVEAIVE Q61425 A dehydrogenase, C4(Carbamidomethyl); K30(Dimethyl); 2 4272.282 4.70 NLKLKNELFQR mitochondrial K32(Dimethyl) T-complex protein 1 N-Term(Dimethyl); TLSGMESYCVR G5E839 1 1330.614 2.17 subunit delta C9(Carbamidomethyl) T-complex protein 1 N-Term(Dimethyl:2H(6)13C(2)); TLSGMESYCVR G5E839 1 1338.657 2.09 subunit delta C9(Carbamidomethyl) Leucine-rich repeat- TLSNLKELHFYDNPIQFVGVSAFQHLP G3UXX4 containing G-protein- K6(HeavyDimethyl) 1 3548.914 2.77 ELR coupled receptor 5 N-Term(Dimethyl); TLSPGDSFSTFDTPYCK Q9JHW2 Omega-amidase NIT2 2 1978.905 3.04 C16(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TLSPGDSFSTFDTPYCK Q9JHW2 Omega-amidase NIT2 C16(Carbamidomethyl); 1 1994.994 2.58 K17(HeavyDimethyl) Isoform 2 of Fibroblast TLSSSSSGHVYPQQAPYWTHPQR Q03142-2 1 2614.260 2.28 growth factor receptor 4 GTP:AMP N-Term(Dimethyl); TLTQCSWLLDGFPR Q9WTP7 phosphotransferase 7 1721.869 3.65 C5(Carbamidomethyl) AK3, mitochondrial GTP:AMP N-Term(Dimethyl:2H(6)13C(2)); TLTQCSWLLDGFPR Q9WTP7 phosphotransferase 5 1729.911 3.25 C5(Carbamidomethyl) AK3, mitochondrial TMAFLEEELPITACGVYTYGKPVPGLV N-Term(Dimethyl); Q61838 Alpha-2-macroglobulin 1 3381.810 4.15 TLR C14(Carbamidomethyl); K21(Dimethyl) Isoform 2 of 4- N-Term(Dimethyl:2H(6)13C(2)); aminobutyrate TMGCLATTHSK P61922-2 C4(Carbamidomethyl); 1 1278.706 1.96 aminotransferase, K11(HeavyDimethyl) mitochondrial Isoform 4 of Double- TMLLLSRSPDAHPKTLPLSGSTFHDQIA Q99MU3-4 stranded RNA-specific K14(HeavyDimethyl); M29(Oxidation) 1 3709.940 3.04 MLSHR adenosine deaminase 2-hydroxyacyl-CoA N-Term(Dimethyl); TMLQNCLPR D3YZ54 2 1160.590 2.42 lyase 1 C6(Carbamidomethyl) 1,25-dihydroxyvitamin K8(HeavyDimethyl); TMMSTFGKMMVTPVELHK Q64441 D(3) 24-hydroxylase, 1 2140.171 2.30 K18(HeavyDimethyl) mitochondrial N-Term(Dimethyl); TMQFEPSTMVYDACR A2AIM2 Talin-1 (Fragment) 1 1863.794 3.22 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TMQFEPSTMVYDACR P26039 Talin-1 1 1871.842 2.26 C14(Carbamidomethyl) Glutamate receptor TMSSIPYQPTPTLGLNLGNDPDR Q61625 N-Term(Dimethyl:2H(6)13C(2)) 1 2523.264 2.45 ionotropic, delta-2 TNCDLYEKLGEYGFQNAILVR P07724 Serum albumin C3(Carbamidomethyl); K8(Dimethyl) 5 2531.250 4.84 C3(Carbamidomethyl); TNCDLYEKLGEYGFQNAILVR P07724 Serum albumin 3 2539.332 4.21 K8(HeavyDimethyl) N-Term(Dimethyl); TNCDLYEKLGEYGFQNAILVR P07724 Serum albumin 16 2559.288 6.66 C3(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TNCDLYEKLGEYGFQNAILVR P07724 Serum albumin C3(Carbamidomethyl); 14 2575.379 7.49 K8(HeavyDimethyl) Guanine nucleotide- C22(Carbamidomethyl); TNHIGHTGYLNTVTVSPDGSLCASGGK P68040 binding protein subunit 2 2779.392 3.19 K27(HeavyDimethyl) beta-2-like 1 Guanine nucleotide- N-Term(Dimethyl); TNHIGHTGYLNTVTVSPDGSLCASGGK P68040 binding protein subunit 1 2799.363 2.94 C22(Carbamidomethyl); K27(Dimethyl) beta-2-like 1 Pyruvate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TNHLVTVEGGWPQFGVGAEICAR Q9D051 E1 component subunit 1 2534.294 2.31 C21(Carbamidomethyl) beta, mitochondrial Isoform 3 of Mitochondrial ubiquitin TNTVPFDLVPHEDGVAVSVR Q8VCM5-3 2 2152.084 2.43 ligase activator of NFKB 1 Kinesin-like protein N-Term(Dimethyl); TPCAETPAEPVDWAFAQRELLEK E9QAN4 1 2714.311 2.97 KIF1A C3(Carbamidomethyl); K23(Dimethyl) Forkhead box protein TPIKETLPVSSTPSKSVLSR E9Q7Y0 K4(Dimethyl); K15(Dimethyl) 1 2183.245 2.50 M1 Epidermal growth factor N-Term(Dimethyl); TPLLSSLSATSNNSTVACINR Q01279 1 2234.148 3.12 receptor C18(Carbamidomethyl) Serine/threonine-protein TPLMMAAENGQTNTVEMLVSSASADL M5(Oxidation); M17(Oxidation); Q505D1 phosphatase 6 regulatory 1 3569.730 2.96 TLQDKSK K31(Dimethyl); K33(Dimethyl) ankyrin repeat subunit A Leucine-rich repeats and TPMDLTIRAGAMAR Q6P1C6 immunoglobulin-like 1 1503.767 2.02 domains protein 3 TPNVSGVLSAMEEMEFQRFITPLK J3QMI8 Protein Gm21827 M14(Oxidation); K24(HeavyDimethyl) 1 2776.441 2.67 Kinesin family member TPSAETPSEPVDWTFAQR A2AH75 2 2018.951 2.45 1B, isoform CRA_a Isoform 2 of Splicing TPVEEVPAAIAPFQGR Q921M3-2 N-Term(Dimethyl:2H(6)13C(2)) 1 1717.969 2.61 factor 3B subunit 3 Isoform 2 of Glutaminyl- N-Term(Dimethyl:2H(6)13C(2)); TPYGYRSFSNIISTLNPEAK Q9CYK2-2 1 2330.284 2.38 peptide cyclotransferase K20(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); TQCPDDSTCCELPTGK P28798 Granulins C9(Carbamidomethyl); 1 1940.889 2.35 C10(Carbamidomethyl); K16(HeavyDimethyl) Eukaryotic translation N-Term(Dimethyl); TQGNVFATDAILATLMSCTR O70194 initiation factor 3 1 2198.091 2.83 C18(Carbamidomethyl) subunit D Eukaryotic translation N-Term(Dimethyl:2H(6)13C(2)); TQGNVFATDAILATLMSCTR O70194 initiation factor 3 1 2206.168 2.72 C18(Carbamidomethyl) subunit D Peptidyl-prolyl cis-trans N-Term(Dimethyl:2H(6)13C(2)); TQLAVCQQR P30416 2 1139.637 2.08 isomerase FKBP4 C6(Carbamidomethyl) TQLPYEYYSLPFCQPIKITYKAENLGEV Transmembrane 9 C13(Carbamidomethyl); K17(Dimethyl); Q8BH24 1 3689.952 2.84 LR superfamily member 4 K21(Dimethyl) Isoform 2 of Protein N-Term(Dimethyl:2H(6)13C(2)); TQPPEDISCIAWNR Q3UPL0-2 1 1722.866 2.15 transport protein Sec31A C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Suppressor of cytokine TQSGTKNLRIQCEGGSFSLQSDPR O35718 K6(HeavyDimethyl); 2 2738.448 3.14 signaling 3 C12(Carbamidomethyl) Glycogen [starch] TQVEQCEPTNDAVR Q8VCB3 C6(Carbamidomethyl) 2 1646.736 2.37 synthase, liver Glycogen [starch] N-Term(Dimethyl); TQVEQCEPTNDAVR Q8VCB3 3 1674.767 4.09 synthase, liver C6(Carbamidomethyl) Glycogen [starch] N-Term(Dimethyl); TQVEQCEPTNDAVRK Q8VCB3 1 1830.903 2.43 synthase, liver C6(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glycogen [starch] TQVEQCEPTNDAVRK Q8VCB3 C6(Carbamidomethyl); 3 1846.990 2.78 synthase, liver K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C6(Carbamidomethyl); C11(Carbamidomethyl); TQVVDCGEYTCKASNEYGSVSCTATL A2ASS6-2 Isoform 2 of Titin K12(HeavyDimethyl); 1 4099.124 3.40 TVTVPTAEKK C22(Carbamidomethyl); K35(HeavyDimethyl); K36(HeavyDimethyl) Isoform 3 of Neutral N-Term(Dimethyl:2H(6)13C(2)); TRDGSDYEGWCWPGSASYPDFTNPR Q8BHN3-3 1 2957.300 3.97 alpha-glucosidase AB C11(Carbamidomethyl) Carbamoyl-phosphate TSACFEPSLDYMVTK Q8C196 synthase [ammonia], C4(Carbamidomethyl); K15(Dimethyl) 5 1776.815 2.95 mitochondrial Carbamoyl-phosphate C4(Carbamidomethyl); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], 1 1784.857 2.82 K15(HeavyDimethyl) mitochondrial Carbamoyl-phosphate C4(Carbamidomethyl); M12(Oxidation); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], 2 1792.809 2.53 K15(Dimethyl) mitochondrial Carbamoyl-phosphate C4(Carbamidomethyl); M12(Oxidation); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], 1 1800.856 2.13 K15(HeavyDimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], 16 1804.845 4.01 C4(Carbamidomethyl); K15(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], C4(Carbamidomethyl); M12(Oxidation); 11 1820.841 3.73 mitochondrial K15(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], C4(Carbamidomethyl); 9 1820.936 4.25 mitochondrial K15(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); TSACFEPSLDYMVTK Q8C196 synthase [ammonia], C4(Carbamidomethyl); M12(Oxidation); 5 1836.930 2.90 mitochondrial K15(HeavyDimethyl) Carbamoyl-phosphate TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], C4(Carbamidomethyl); K15(Dimethyl) 3 2143.065 2.68 mitochondrial Carbamoyl-phosphate C4(Carbamidomethyl); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 2 2151.106 3.01 K15(HeavyDimethyl) mitochondrial Carbamoyl-phosphate C4(Carbamidomethyl); M12(Oxidation); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 4 2159.050 2.98 K15(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], 28 2171.082 5.36 C4(Carbamidomethyl); K15(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], C4(Carbamidomethyl); M12(Oxidation); 15 2187.080 4.31 mitochondrial K15(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], C4(Carbamidomethyl); 32 2187.168 4.94 mitochondrial K15(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); TSACFEPSLDYMVTKIPR Q8C196 synthase [ammonia], C4(Carbamidomethyl); M12(Oxidation); 5 2203.169 3.51 mitochondrial K15(HeavyDimethyl) K7(HeavyDimethyl); C9(Carbamidomethyl); TSELSVKSCESDAPFPVHPGTPECCTKE Vitamin D-binding P21614 C24(Carbamidomethyl); 1 3676.771 3.12 GLER protein C25(Carbamidomethyl); K27(HeavyDimethyl) N-Term(Dimethyl); K7(Dimethyl); TSELSVKSCESDAPFPVHPGTPECCTKE Vitamin D-binding C9(Carbamidomethyl); P21614 1 3688.710 3.52 GLER protein C24(Carbamidomethyl); C25(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); TSELSVKSCESDAPFPVHPGTPECCTKE Vitamin D-binding C9(Carbamidomethyl); P21614 2 3712.882 3.45 GLER protein C24(Carbamidomethyl); C25(Carbamidomethyl); K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); DNA polymerase zeta C5(Carbamidomethyl); TSETCSPGNAASEESQTPNCFVTSLK Q61493 1 2874.352 2.20 catalytic subunit C20(Carbamidomethyl); K26(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K6(HeavyDimethyl); TSFYSKEVPQMCIPGKIEEVVLEAR F8VPN4 Protein Agl 1 3018.702 2.94 C12(Carbamidomethyl); K16(HeavyDimethyl) Isoform 3 of Protein TSGPSAAGLETTYTGGNGFSTSYNSQR Q8BL99-3 N-Term(Dimethyl) 1 2739.215 2.64 dopey-1 Isocitrate dehydrogenase N-Term(Dimethyl); TSLDLYANVIHCK P70404 [NAD] subunit gamma 1 1589.835 2.70 C12(Carbamidomethyl); K13(Dimethyl) 1, mitochondrial

Isocitrate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TSLDLYANVIHCK P70404 [NAD] subunit gamma C12(Carbamidomethyl); 1 1605.916 2.67 1, mitochondrial K13(HeavyDimethyl)

Tubulin polyglutamylase N-Term(Dimethyl:2H(6)13C(2)); TSMNYMLATRLFQDRVSTEGAPELK D3YVZ5 1 2946.595 2.77 TTLL5 M3(Oxidation); K25(HeavyDimethyl) Isoform 3 of TSSAEMPTIPLGSAVEAIRVNCSDNEFT N-Term(Dimethyl:2H(6)13C(2)); Q8CAQ8-3 Mitochondrial inner 1 4481.325 3.46 QALTAAIPPESLTR C22(Carbamidomethyl) membrane protein Vacuolar protein sorting- TSSSSGGLTISSLLKEKEGSEVAR E9PWD1 associated protein 53 K15(Dimethyl); K17(Dimethyl) 1 2479.342 2.51 homolog (Fragment) Origin recognition TSVNSQREYQLVK O88708 K13(Dimethyl) 1 1579.847 2.42 complex subunit 4 N-Term(Dimethyl); TSYPDCIK Q921I1 Serotransferrin 1 1039.508 2.18 C6(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TSYPDCIK Q921I1 Serotransferrin C6(Carbamidomethyl); 1 1055.596 2.02 K8(HeavyDimethyl) N-Term(Dimethyl); TTAPSVYPLAPVCGGTTGSSVTLGCLV F6TQW2 Protein Ighg2c C13(Carbamidomethyl); 1 2849.490 2.95 K C25(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); TTAPSVYPLAPVCGGTTGSSVTLGCLV C13(Carbamidomethyl); F6TQW2 Protein Ighg2c 1 2865.568 3.36 K C25(Carbamidomethyl); K28(HeavyDimethyl) NADH dehydrogenase N-Term(Dimethyl); TTGLVGLAVCDTPHER Q9CPP6 [ubiquinone] 1 alpha 4 1753.884 4.56 C10(Carbamidomethyl) subcomplex subunit 5

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TTGLVGLAVCDTPHER Q9CPP6 [ubiquinone] 1 alpha 1 1761.930 3.55 C10(Carbamidomethyl) subcomplex subunit 5 N-Term(Dimethyl); Kinesin-1 heavy chain TTIVICCSPSSYNESETK E9QAK5 C6(Carbamidomethyl); 1 2131.960 3.00 (Fragment) C7(Carbamidomethyl); K18(Dimethyl) Calmodulin-regulated TTPEGSELNIPHVVSWAQIPEEAGVAP Q8C1B1 spectrin-associated M39(Oxidation) 2 4939.442 3.69 GRDTTQLLASEMVHLRMR protein 2 N-Term(Dimethyl); TTPPSVYPLAPGCGDTTGSSVTLGCLV Isoform 2 of Ig gamma- P01867-2 C13(Carbamidomethyl); 2 2891.464 2.54 K 2B chain C region C25(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl); TTTSAAMVHCLR Q8VCC2 Liver carboxylesterase 1 4 1375.681 2.83 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TTTSAAMVHCLR Q8VCC2 Liver carboxylesterase 1 1 1383.722 2.61 C10(Carbamidomethyl) Expressed sequence N-Term(Dimethyl); TTTSAVIVHCMR Q91WU0 5 1403.712 3.16 AU018778 C10(Carbamidomethyl) Expressed sequence N-Term(Dimethyl:2H(6)13C(2)); TTTSAVIVHCMR Q91WU0 2 1411.752 2.84 AU018778 C10(Carbamidomethyl) N-Term(Dimethyl); TTTSAVMVHCLR Q8VCT4 Carboxylesterase 1D 3 1403.707 2.86 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TTTSAVMVHCLR Q8VCT4 Carboxylesterase 1D 1 1411.751 2.65 C10(Carbamidomethyl) Eukaryotic translation TTYKYEMINKQNEQMHALLAIALTMY K4(Dimethyl); K10(Dimethyl); Q8QZY1 initiation factor 3 1 3574.755 2.87 PMR M15(Oxidation) subunit L N-Term(Dimethyl:2H(6)13C(2)); TTYQALPCLPSMYSYPNR Q8CIE6 Coatomer subunit alpha 1 2198.076 2.36 C8(Carbamidomethyl) N-Term(Dimethyl); Dihydrolipoyl C3(Carbamidomethyl); K6(Dimethyl); TVCIEKNETLGGTCLNVGCIPSK O08749 dehydrogenase, 7 2634.327 4.87 C14(Carbamidomethyl); mitochondrial C19(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); Dihydrolipoyl K6(HeavyDimethyl); TVCIEKNETLGGTCLNVGCIPSK O08749 dehydrogenase, 4 2658.460 4.26 C14(Carbamidomethyl); mitochondrial C19(Carbamidomethyl); K23(HeavyDimethyl) 60S ribosomal protein C11(Carbamidomethyl); TVFAEHISDECKR P27659 1 1627.827 2.23 L3 K12(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); TVFAEHISDECKR P27659 5 1647.808 3.37 L3 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein TVFAEHISDECKR P27659 C11(Carbamidomethyl); 2 1663.904 2.54 L3 K12(HeavyDimethyl) Propionyl-CoA N-Term(Dimethyl); TVGIVGNQPNVASGCLDINSSVK E9Q1J7 carboxylase beta chain, 2 2385.244 4.63 C15(Carbamidomethyl); K23(Dimethyl) mitochondrial Propionyl-CoA N-Term(Dimethyl:2H(6)13C(2)); TVGIVGNQPNVASGCLDINSSVK E9Q1J7 carboxylase beta chain, C15(Carbamidomethyl); 2 2401.325 3.97 mitochondrial K23(HeavyDimethyl) Propionyl-CoA N-Term(Dimethyl); TVGIVGNQPNVASGCLDINSSVKGAR E9Q1J7 carboxylase beta chain, 3 2669.389 4.33 C15(Carbamidomethyl); K23(Dimethyl) mitochondrial Propionyl-CoA N-Term(Dimethyl:2H(6)13C(2)); TVGIVGNQPNVASGCLDINSSVKGAR E9Q1J7 carboxylase beta chain, C15(Carbamidomethyl); 3 2685.492 3.61 mitochondrial K23(HeavyDimethyl) N-Term(Dimethyl); TVLCGTCGQPADKAAGGAGAQVGGSI P48678 Prelamin-A/C C4(Carbamidomethyl); 2 3665.792 4.00 SSGSSASSVTVTR C7(Carbamidomethyl); K13(Dimethyl) Putative L-aspartate TVLYEGPVRGLCPLAPR F6S4J6 dehydrogenase C12(Carbamidomethyl) 2 1898.027 2.20 (Fragment) C13(Carbamidomethyl); TVMDDFAQFLDTCCK P07724 Serum albumin C14(Carbamidomethyl); 1 1886.846 2.56 K15(HeavyDimethyl) N-Term(Dimethyl); TVMDDFAQFLDTCCK P07724 Serum albumin C13(Carbamidomethyl); 5 1906.838 5.33 C14(Carbamidomethyl); K15(Dimethyl)

N-Term(Dimethyl); M3(Oxidation); TVMDDFAQFLDTCCK P07724 Serum albumin C13(Carbamidomethyl); 6 1922.834 4.21 C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C13(Carbamidomethyl); TVMDDFAQFLDTCCK P07724 Serum albumin 11 1922.919 5.00 C14(Carbamidomethyl); K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); M3(Oxidation); C13(Carbamidomethyl); TVMDDFAQFLDTCCK P07724 Serum albumin 4 1938.921 3.47 C14(Carbamidomethyl); K15(HeavyDimethyl)

N-Term(Dimethyl); TVMDDFAQFLDTCCKAADKDTCFSTE C13(Carbamidomethyl); P07724 Serum albumin 8 3897.793 4.15 GPNLVTR C14(Carbamidomethyl); K15(Dimethyl); K19(Dimethyl); C22(Carbamidomethyl)

N-Term(Dimethyl); M3(Oxidation); TVMDDFAQFLDTCCKAADKDTCFSTE C13(Carbamidomethyl); P07724 Serum albumin 1 3913.775 3.58 GPNLVTR C14(Carbamidomethyl); K15(Dimethyl); K19(Dimethyl); C22(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C13(Carbamidomethyl); TVMDDFAQFLDTCCKAADKDTCFSTE C14(Carbamidomethyl); P07724 Serum albumin 6 3921.920 4.46 GPNLVTR K15(HeavyDimethyl); K19(HeavyDimethyl); C22(Carbamidomethyl) TVMVQEGNVEGACRTLNRILTTDGLT C13(Carbamidomethyl); J3QPA0 Protein Gm6686 1 3353.746 2.60 EVIK K30(HeavyDimethyl) E3 ubiquitin-protein N-Term(Dimethyl:2H(6)13C(2)); TVNMEDSWAGEEGAASSASASVTFR Q8CH72 2 2612.229 2.44 ligase TRIM32 M4(Oxidation) N-Term(Dimethyl); K9(Dimethyl); TVNTDVILKQEILKEAEPQAWLQEVSQ Zinc finger protein 394 E0CYH2 K14(Dimethyl); M29(Oxidation); 1 4035.160 3.59 GMVPALTK (Fragment) K35(Dimethyl) TVPAAVPGICFLSGGMSEEDATLNLNA Fructose-bisphosphate Q91Y97 C10(Carbamidomethyl) 4 3117.568 3.02 INR aldolase B

TVPAAVPGICFLSGGMSEEDATLNLNA Fructose-bisphosphate N-Term(Dimethyl); Q91Y97 11 3145.580 4.82 INR aldolase B C10(Carbamidomethyl)

TVPAAVPGICFLSGGMSEEDATLNLNA Fructose-bisphosphate N-Term(Dimethyl:2H(6)13C(2)); Q91Y97 7 3153.631 4.13 INR aldolase B C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TVPAAVPGICFLSGGMSEEDATLNLNA Fructose-bisphosphate C10(Carbamidomethyl); Q91Y97 1 4224.254 3.16 INRCPLPRPWK aldolase B C31(Carbamidomethyl); K38(HeavyDimethyl) N-Term(Dimethyl); TVPFCSTFAAFFTR P40142 Transketolase 2 1679.822 2.64 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TVPFCSTFAAFFTR P40142 Transketolase 1 1687.865 2.34 C5(Carbamidomethyl) Isoform 4 of E3 TVPSPPISPQALVEGENDEQSSPDQVSA A2AN08-4 ubiquitin-protein ligase K30(Dimethyl); K32(Dimethyl) 1 3362.728 3.20 AKTK UBR4 [3-methyl-2- oxobutanoate TVTSFYNQSAIDVAAEKPSVRLTPTMM dehydrogenase K17(HeavyDimethyl); M26(Oxidation); D3Z7R0 1 4603.349 2.89 LYSGRSQDGSHLLK [lipoamide]] kinase, M27(Oxidation); K41(HeavyDimethyl) mitochondrial (Fragment) Carbamoyl-phosphate N-Term(Dimethyl); TVVVNCNPETVSTDFDECDK Q8C196 synthase [ammonia], C6(Carbamidomethyl); 1 2385.059 3.72 mitochondrial C18(Carbamidomethyl); K20(Dimethyl) Carbamoyl-phosphate TVVVNCNPETVSTDFDECDKLYFEELS C6(Carbamidomethyl); Q8C196 synthase [ammonia], 2 3636.666 3.05 LER C18(Carbamidomethyl); K20(Dimethyl) mitochondrial Carbamoyl-phosphate C6(Carbamidomethyl); TVVVNCNPETVSTDFDECDKLYFEELS Q8C196 synthase [ammonia], C18(Carbamidomethyl); 2 3644.731 3.49 LER mitochondrial K20(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); TVVVNCNPETVSTDFDECDKLYFEELS Q8C196 synthase [ammonia], C6(Carbamidomethyl); 15 3664.708 5.41 LER mitochondrial C18(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate TVVVNCNPETVSTDFDECDKLYFEELS C6(Carbamidomethyl); Q8C196 synthase [ammonia], 8 3680.788 5.37 LER C18(Carbamidomethyl); mitochondrial K20(HeavyDimethyl) Isoform 3 of E3 TVVVQWDQGTRTNYR Q8R516-3 ubiquitin-protein ligase 2 1822.945 2.23 MIB2 Formimidoyltransferase- N-Term(Dimethyl); TVYTFVGQPECVVEGALHAAR Q91XD4 7 2332.180 5.09 cyclodeaminase C11(Carbamidomethyl) Formimidoyltransferase- N-Term(Dimethyl:2H(6)13C(2)); TVYTFVGQPECVVEGALHAAR Q91XD4 4 2340.218 4.09 cyclodeaminase C11(Carbamidomethyl) Succinate dehydrogenase TYFSCTSAHTSTGDGTAMVTR Q8K2B3 [ubiquinone] C5(Carbamidomethyl) 6 2250.970 4.20 flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl); TYFSCTSAHTSTGDGTAMVTR Q8K2B3 [ubiquinone] 14 2279.001 5.18 C5(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl); TYFSCTSAHTSTGDGTAMVTR Q8K2B3 [ubiquinone] 4 2294.997 2.92 C5(Carbamidomethyl); M18(Oxidation) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TYFSCTSAHTSTGDGTAMVTR Q8K2B3 [ubiquinone] 11 2287.047 5.47 C5(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); TYFSCTSAHTSTGDGTAMVTR Q8K2B3 [ubiquinone] 1 2303.037 2.82 C5(Carbamidomethyl); M18(Oxidation) flavoprotein subunit, mitochondrial TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase C4(Carbamidomethyl) 10 2223.965 5.30

TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase C4(Carbamidomethyl); M8(Oxidation) 2 2239.969 2.50 N-Term(Dimethyl); TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase 7 2251.993 5.61 C4(Carbamidomethyl) N-Term(Dimethyl); TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase 4 2267.995 3.39 C4(Carbamidomethyl); M8(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase 5 2260.046 5.22 C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); TYGCSPEMYYQPTSVGEVR P58710 L-gulonolactone oxidase 2 2276.029 2.86 C4(Carbamidomethyl); M8(Oxidation) N-Term(Dimethyl:2H(6)13C(2)); TYGCSPEMYYQPTSVGEVREVLALAR P58710 L-gulonolactone oxidase 1 3012.506 3.06 C4(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl); TYGICGAIR Q9CQR2 2 1038.538 2.53 S21 C5(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); TYGICGAIR Q9CQR2 2 1046.581 1.99 S21 C5(Carbamidomethyl) Cytosolic 10- N-Term(Dimethyl); TYSTINPTDGSVICQVSLAQVSDVDKA Q8R0Y6 formyltetrahydrofolate C14(Carbamidomethyl); K26(Dimethyl); 1 3392.766 4.34 VAAAK dehydrogenase K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytosolic 10- TYSTINPTDGSVICQVSLAQVSDVDKA C14(Carbamidomethyl); Q8R0Y6 formyltetrahydrofolate 2 3416.899 3.63 VAAAK K26(HeavyDimethyl); dehydrogenase K32(HeavyDimethyl) Uncharacterized protein VAAAAAAFRGSANRCWNLSVDTSNR A2AG06 C15(Carbamidomethyl) 2 2665.272 2.39 C17orf104 homolog 4- N-Term(Dimethyl); VAAELQAGTCYINNYNVSPVELPFGG Q9JLJ2 trimethylaminobutyralde C10(Carbamidomethyl); K28(Dimethyl); 3 3286.682 4.54 YKK hyde dehydrogenase K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- VAAELQAGTCYINNYNVSPVELPFGG C10(Carbamidomethyl); Q9JLJ2 trimethylaminobutyralde 1 3310.813 4.26 YKK K28(HeavyDimethyl); hyde dehydrogenase K29(HeavyDimethyl) VAAGVLCELAQDKEAAEAIEAEGATA Catenin beta-1 N-Term(Dimethyl); F7CRC6 1 3689.908 3.40 PLTELLHSR (Fragment) C7(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform Cytoplasmic of VAALTGLPFVTAPNKFEALAAHDALV K15(HeavyDimethyl); P97807-2 Fumarate hydratase, 1 4309.353 4.79 ELSGAMNTAACSLMK C37(Carbamidomethyl); mitochondrial K41(HeavyDimethyl) Ornithine N-Term(Dimethyl); VAASDWTFLHCLPR Q8R1A8 carbamoyltransferase, 2 1700.860 2.66 C11(Carbamidomethyl) mitochondrial Ornithine N-Term(Dimethyl:2H(6)13C(2)); VAASDWTFLHCLPR Q8R1A8 carbamoyltransferase, 1 1708.898 2.71 C11(Carbamidomethyl) mitochondrial Ornithine VAASDWTFLHCLPRKPEEVDDEVFYS N-Term(Dimethyl); Q8R1A8 carbamoyltransferase, 4 3419.666 5.02 PR C11(Carbamidomethyl); K15(Dimethyl) mitochondrial Ornithine N-Term(Dimethyl:2H(6)13C(2)); VAASDWTFLHCLPRKPEEVDDEVFYS Q8R1A8 carbamoyltransferase, C11(Carbamidomethyl); 6 3435.758 5.37 PR mitochondrial K15(HeavyDimethyl) Sarcosine N-Term(Dimethyl); VAAVETEHGSIQTPCVVNCAGVWASK Q99LB7 dehydrogenase, C15(Carbamidomethyl); 8 2826.381 5.46 mitochondrial C19(Carbamidomethyl); K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sarcosine C15(Carbamidomethyl); VAAVETEHGSIQTPCVVNCAGVWASK Q99LB7 dehydrogenase, 6 2842.476 6.10 C19(Carbamidomethyl); mitochondrial K26(HeavyDimethyl) Sarcosine N-Term(Dimethyl); VAAVETEHGSIQTPCVVNCAGVWASK Q99LB7 dehydrogenase, C15(Carbamidomethyl); 14 3138.582 5.30 VGR mitochondrial C19(Carbamidomethyl); K26(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Sarcosine VAAVETEHGSIQTPCVVNCAGVWASK C15(Carbamidomethyl); Q99LB7 dehydrogenase, 6 3154.669 5.66 VGR C19(Carbamidomethyl); mitochondrial K26(HeavyDimethyl) VAAVGPAGAGEPVHLPQMVKIAPAPA N-Term(Dimethyl:2H(6)13C(2)); E9QQ96 Obscurin 1 3860.128 3.23 PAPAPAPAPAPETR M18(Oxidation); K20(HeavyDimethyl) VADAYSDVMVTYTMTSSLYFITFGMG Patched domain- E9QMK6 N-Term(Dimethyl); K37(Dimethyl) 1 4083.938 2.87 ASPFTNIEAVK containing protein 4 Sulfide:quinone N-Term(Dimethyl); VAELNPDENCIR Q9R112 oxidoreductase, 2 1457.704 2.29 C10(Carbamidomethyl) mitochondrial Sulfide:quinone N-Term(Dimethyl:2H(6)13C(2)); VAELNPDENCIR Q9R112 oxidoreductase, 2 1465.745 2.16 C10(Carbamidomethyl) mitochondrial Isoform 2 of DDB1- and N-Term(Dimethyl); VAELSATQCCK Q8N7N5-2 CUL4-associated factor C9(Carbamidomethyl); 1 1322.642 2.21 8 C10(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of DDB1- and C9(Carbamidomethyl); VAELSATQCCK Q8N7N5-2 CUL4-associated factor 1 1338.728 1.98 C10(Carbamidomethyl); 8 K11(HeavyDimethyl) Peroxisomal leader N-Term(Dimethyl); VAEQAGCVVSASR Q9DBA6 peptide-processing 3 1361.682 2.81 C7(Carbamidomethyl) protease Peroxisomal leader N-Term(Dimethyl:2H(6)13C(2)); VAEQAGCVVSASR Q9DBA6 peptide-processing 1 1369.730 1.97 C7(Carbamidomethyl) protease N-Term(Dimethyl); VAIEPGVPREVDEYCK Q64442 Sorbitol dehydrogenase 3 1916.979 3.69 C15(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VAIEPGVPREVDEYCK Q64442 Sorbitol dehydrogenase C15(Carbamidomethyl); 4 1933.064 2.89 K16(HeavyDimethyl) Cis-retinol/3alpha VAIIEPGFFLTGMASSARLCSNIQMLW hydroxysterol short- Q8K3M1 C20(Carbamidomethyl) 2 3928.924 2.93 DQTSSEIR chain dehydrogenase- like protein K4(Dimethyl); M11(Oxidation); IL2-inducible T-cell VAIKTIQEGAMSEEDFIEEAEVMMK Q5STT8 M23(Oxidation); M24(Oxidation); 2 2932.405 2.86 kinase K25(Dimethyl) VAKENGVDAVHPGYGFLSERADFAQA N-Term(Dimethyl); K3(Dimethyl); G5E8R3 Pyruvate carboxylase 1 3590.726 4.37 CQDAGVR C27(Carbamidomethyl) Bile acyl-CoA N-Term(Dimethyl); VALVCTGSEGSSITNSQLDAR Q4LDG0 6 2193.070 6.09 synthetase C5(Carbamidomethyl) Bile acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); VALVCTGSEGSSITNSQLDAR Q4LDG0 8 2201.121 6.29 synthetase C5(Carbamidomethyl) VANYQRDGPMCMHDNQGGAPNYYP M10(Oxidation); P24270 Catalase 1 3931.671 2.76 NSFSAPEQQR C11(Carbamidomethyl); M12(Oxidation) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl); P24270 Catalase 14 3927.695 5.25 NSFSAPEQQR C11(Carbamidomethyl) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl); P24270 Catalase 3 3943.684 4.24 NSFSAPEQQR C11(Carbamidomethyl); M12(Oxidation) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl); M10(Oxidation); P24270 Catalase 2 3943.695 3.73 NSFSAPEQQR C11(Carbamidomethyl) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl); M10(Oxidation); P24270 Catalase 1 3959.692 3.32 NSFSAPEQQR C11(Carbamidomethyl); M12(Oxidation) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 13 3935.742 5.49 NSFSAPEQQR C11(Carbamidomethyl) VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 2 3951.724 4.18 NSFSAPEQQR C11(Carbamidomethyl); M12(Oxidation)

VANYQRDGPMCMHDNQGGAPNYYP N-Term(Dimethyl:2H(6)13C(2)); P24270 Catalase 4 3951.736 4.74 NSFSAPEQQR M10(Oxidation); C11(Carbamidomethyl)

N-Term(Dimethyl:2H(6)13C(2)); VANYQRDGPMCMHDNQGGAPNYYP P24270 Catalase M10(Oxidation); 1 3967.730 3.34 NSFSAPEQQR C11(Carbamidomethyl); M12(Oxidation) N-Term(Dimethyl); VAPEEVSEVIFGHVLTAGCGQNPTR F2Z459 Protein Acat3 7 2695.342 4.09 C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VAPEEVSEVIFGHVLTAGCGQNPTR F2Z459 Protein Acat3 2 2703.399 4.54 C19(Carbamidomethyl) VAQDMTQPLSHYYINASHNTYLIEDQF Inactive phospholipase Q3USB7 N-Term(Dimethyl); M5(Oxidation) 1 3398.573 2.92 R C-like protein 1 N-Term(Dimethyl); K11(Dimethyl); VAQWLIQEPHKAATFFGCIGIDKFGEIL Isoform Short of P55264-2 C18(Carbamidomethyl); K23(Dimethyl); 1 3428.900 3.15 K Adenosine kinase K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K11(HeavyDimethyl); VAQWLIQEPHKAATFFGCIGIDKFGEIL Isoform Short of P55264-2 C18(Carbamidomethyl); 4 3461.080 3.94 K Adenosine kinase K23(HeavyDimethyl); K29(HeavyDimethyl) Very long-chain-specific acyl-CoA N-Term(Dimethyl); VASGQALAAFCLTEPSSGSDVASIR B1AR28 6 2522.264 6.00 dehydrogenase, C11(Carbamidomethyl) mitochondrial Very long-chain-specific acyl-CoA N-Term(Dimethyl:2H(6)13C(2)); VASGQALAAFCLTEPSSGSDVASIR B1AR28 3 2530.300 6.21 dehydrogenase, C11(Carbamidomethyl) mitochondrial VASLIVDGVSSVPSCRVITESSYTAAHG Fibrous sheath- A2ARZ3 C15(Carbamidomethyl) 1 3576.770 3.05 DLDTNR interacting protein 2 K6(Dimethyl); C15(Carbamidomethyl); VATDPKEVLLLMSACK Q8BGN8 Synaptoporin 1 1830.994 2.50 K16(Dimethyl) VAVDAPVSSVALR Q64374 Regucalcin 2 1283.733 2.35 Ribosyldihydronicotina N-Term(Dimethyl:2H(6)13C(2)); VAVEELSKQGCTVTVSDLYSMNFEPR Q9JI75 mide dehydrogenase K8(HeavyDimethyl); 1 3031.562 2.73 [quinone] C11(Carbamidomethyl) Aconitate hydratase, N-Term(Dimethyl); VAVPSTIHCDHLIEAQVGGEK Q99KI0 1 2316.209 2.59 mitochondrial C9(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, VAVPSTIHCDHLIEAQVGGEK Q99KI0 C9(Carbamidomethyl); 3 2332.296 2.89 mitochondrial K21(HeavyDimethyl) Aconitate hydratase, N-Term(Dimethyl); VAVPSTIHCDHLIEAQVGGEKDLR Q99KI0 1 2700.414 2.95 mitochondrial C9(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, VAVPSTIHCDHLIEAQVGGEKDLR Q99KI0 C9(Carbamidomethyl); 2 2716.502 3.47 mitochondrial K21(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aconitate hydratase, VAVPSTIHCDHLIEAQVGGEKDLRR Q99KI0 C9(Carbamidomethyl); 2 2872.604 2.81 mitochondrial K21(HeavyDimethyl) N-acyl-aromatic-L- amino acid N-Term(Dimethyl); VAVTGGTHGNEMCGVYLAR Q91XE4 10 2019.972 4.99 amidohydrolase C13(Carbamidomethyl) (carboxylate-forming) N-acyl-aromatic-L- amino acid N-Term(Dimethyl:2H(6)13C(2)); VAVTGGTHGNEMCGVYLAR Q91XE4 8 2028.017 5.71 amidohydrolase C13(Carbamidomethyl) (carboxylate-forming) N-acyl-aromatic-L- amino acid N-Term(Dimethyl:2H(6)13C(2)); VAVTGGTHGNEMCGVYLAR Q91XE4 2 2044.007 2.36 amidohydrolase M12(Oxidation); C13(Carbamidomethyl) (carboxylate-forming) Adenosylhomocysteinas N-Term(Dimethyl); K12(Dimethyl); VAVVAGYGDVGKGCAQALR P50247 11 1947.048 5.66 e C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas VAVVAGYGDVGKGCAQALR P50247 K12(HeavyDimethyl); 13 1963.132 5.71 e C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas VAVVAGYGDVGKGCAQALRGFGAR P50247 K12(HeavyDimethyl); 1 2451.380 2.89 e C14(Carbamidomethyl) Actin-related protein 2/3 N-Term(Dimethyl); VAWVSHDSTVCLVDADKK F6VVE6 complex subunit 1B C11(Carbamidomethyl); K17(Dimethyl); 1 2114.088 2.68 (Fragment) K18(Dimethyl)

N-Term(Dimethyl); VCEDFGVIATFDPKPIPGNWNGAGCHT P15105 Glutamine synthetase C2(Carbamidomethyl); K14(Dimethyl); 1 3620.744 3.39 NFSTK C25(Carbamidomethyl); K32(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); VCEDFGVIATFDPKPIPGNWNGAGCHT P15105 Glutamine synthetase K14(HeavyDimethyl); 1 3644.866 3.60 NFSTK C25(Carbamidomethyl); K32(HeavyDimethyl) N-Term(Dimethyl); 40S ribosomal protein VCEEIAIIPSKK P63276 C2(Carbamidomethyl); K11(Dimethyl); 8 1470.855 3.19 S17 K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein C2(Carbamidomethyl); VCEEIAIIPSKK P63276 4 1494.987 2.94 S17 K11(HeavyDimethyl); K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); GTP-binding nuclear VCENIPIVLCGNKVDIKDR P62827 C10(Carbamidomethyl); 1 2350.399 2.50 protein Ran K13(HeavyDimethyl); K17(HeavyDimethyl) Isoform 2 of 2- N-Term(Dimethyl); oxoisovalerate VCGYDTPFPHIFEPFYIPDKWK Q6P3A8-2 C2(Carbamidomethyl); K20(Dimethyl); 2 2840.432 3.08 dehydrogenase subunit K22(Dimethyl) beta, mitochondrial

Glycerol-3-phosphate N-Term(Dimethyl); VCIVGSGNWGSAIAK E0CXN5 dehydrogenase 6 1574.833 3.03 C2(Carbamidomethyl); K15(Dimethyl) [NAD(+)], cytoplasmic N-Term(Dimethyl); VCKKDVELNGVYIPK Q64459 Cytochrome P450 3A11 C2(Carbamidomethyl); K3(Dimethyl); 2 1874.077 2.97 K4(Dimethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); VCKKDVELNGVYIPK Q64459 Cytochrome P450 3A11 K3(HeavyDimethyl); 8 1906.257 3.06 K4(HeavyDimethyl); K15(HeavyDimethyl) Estradiol 17 beta- N-Term(Dimethyl); VCLEQSLK D3Z3P8 dehydrogenase 5 3 1032.572 2.36 C2(Carbamidomethyl); K8(Dimethyl) (Fragment) Estradiol 17 beta- N-Term(Dimethyl:2H(6)13C(2)); VCLEQSLK D3Z3P8 dehydrogenase 5 C2(Carbamidomethyl); 1 1048.663 2.23 (Fragment) K8(HeavyDimethyl) N-Term(Dimethyl); Alcohol dehydrogenase VCLIGCGFSTGYGSAVK P00329 C2(Carbamidomethyl); 1 1831.902 2.94 1 C6(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase C2(Carbamidomethyl); VCLIGCGFSTGYGSAVK P00329 1 1847.995 3.12 1 C6(Carbamidomethyl); K17(HeavyDimethyl) N-Term(Dimethyl); Alcohol dehydrogenase VCLLGCGISTGYGAAVNTAK P28474 C2(Carbamidomethyl); 2 2068.058 3.90 class-3 C6(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl); VCLLHEKTPVSEHVTK P07724 Serum albumin C2(Carbamidomethyl); K7(Dimethyl); 10 1961.081 5.68 K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); VCLLHEKTPVSEHVTK P07724 Serum albumin 2 1985.214 4.08 K7(HeavyDimethyl); K16(HeavyDimethyl) N-Term(Dimethyl); C2(Carbamidomethyl); K7(Dimethyl); VCLLHEKTPVSEHVTKCCSGSLVER P07724 Serum albumin 3 3009.523 4.23 K16(Dimethyl); C17(Carbamidomethyl); C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C2(Carbamidomethyl); K7(HeavyDimethyl); VCLLHEKTPVSEHVTKCCSGSLVER P07724 Serum albumin 2 3033.645 3.94 K16(HeavyDimethyl); C17(Carbamidomethyl); C18(Carbamidomethyl) Methylmalonate- semialdehyde N-Term(Dimethyl); VCNLIDSGTKEGASILLDGR Q9EQ20 dehydrogenase 11 2174.143 4.79 C2(Carbamidomethyl); K10(Dimethyl) [acylating], mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl:2H(6)13C(2)); VCNLIDSGTKEGASILLDGR Q9EQ20 dehydrogenase C2(Carbamidomethyl); 5 2190.231 4.60 [acylating], K10(HeavyDimethyl) mitochondrial Methylmalonate- semialdehyde N-Term(Dimethyl); VCNLIDSGTKEGASILLDGRR Q9EQ20 dehydrogenase 3 2330.248 2.94 C2(Carbamidomethyl); K10(Dimethyl) [acylating], mitochondrial Isoform 2 of DNA C2(Carbamidomethyl); K5(Dimethyl); VCSDKNKPNGQYQILPSR Q9QUG2-2 2 2160.098 2.35 polymerase kappa K7(Dimethyl) 60S ribosomal protein N-Term(Dimethyl); VCTLAIIDPGDSDIIR P62889 9 1785.944 4.35 L30 C2(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); VCTLAIIDPGDSDIIR P62889 6 1793.983 4.33 L30 C2(Carbamidomethyl) N-Term(Dimethyl); C2(Carbamidomethyl); C4(Carbamidomethyl); C6(Carbamidomethyl); VCVCVCVCVCVCVCVCKHFPGKLILH C8(Carbamidomethyl); E9PZI3 Protein Gm8369 1 4052.987 2.86 CSVFGR C10(Carbamidomethyl); C12(Carbamidomethyl); C14(Carbamidomethyl); C16(Carbamidomethyl); K17(Dimethyl); K22(Dimethyl); C27(Carbamidomethyl)

Isocitrate dehydrogenase N-Term(Dimethyl); VCVQTVESGAMTK P54071 1 1465.738 2.19 [NADP], mitochondrial C2(Carbamidomethyl); K13(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); Isocitrate dehydrogenase VCVQTVESGAMTK P54071 C2(Carbamidomethyl); 2 1481.824 2.25 [NADP], mitochondrial K13(HeavyDimethyl)

Glycerol-3-phosphate N-Term(Dimethyl); VCYEGQPVGEFIR E0CXN5 dehydrogenase 7 1581.769 2.90 C2(Carbamidomethyl) [NAD(+)], cytoplasmic

Glycerol-3-phosphate N-Term(Dimethyl:2H(6)13C(2)); VCYEGQPVGEFIR E0CXN5 dehydrogenase 3 1589.815 2.22 C2(Carbamidomethyl) [NAD(+)], cytoplasmic Endoplasmic reticulum N-Term(Dimethyl); VDCDQHSDIAQR Q9D1Q6 1 1471.658 3.39 resident protein 44 C3(Carbamidomethyl) Endoplasmic reticulum N-Term(Dimethyl:2H(6)13C(2)); VDCDQHSDIAQR Q9D1Q6 2 1479.704 2.60 resident protein 44 C3(Carbamidomethyl) N-Term(Dimethyl); Thioredoxin domain- VDCTADSDVCSAQGVR E9PXX7 C3(Carbamidomethyl); 1 1767.761 2.97 containing protein 5 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Thioredoxin domain- VDCTADSDVCSAQGVR E9PXX7 C3(Carbamidomethyl); 1 1775.801 2.17 containing protein 5 C10(Carbamidomethyl) N-Term(Dimethyl); Protein disulfide- C3(Carbamidomethyl); VDCTANTNTCNKYGVSGYPTLK P27773 2 2547.212 3.13 isomerase A3 C10(Carbamidomethyl); K12(Dimethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C3(Carbamidomethyl); Protein disulfide- VDCTANTNTCNKYGVSGYPTLK P27773 C10(Carbamidomethyl); 3 2571.341 4.58 isomerase A3 K12(HeavyDimethyl); K22(HeavyDimethyl) N-Term(Dimethyl); VDDEANLERVCLIGCGFSSGYGAAINT Alcohol dehydrogenase Q9QYY9 C11(Carbamidomethyl); 1 3143.520 3.21 AK 4 C15(Carbamidomethyl); K29(Dimethyl) VDEFPLCGHMVSDEYEQLSSEALEAA 60S ribosomal protein N-Term(Dimethyl); I7HLV2 5 3110.413 4.72 R L10 (Fragment) C7(Carbamidomethyl) VDEFPLCGHMVSDEYEQLSSEALEAA 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); I7HLV2 3 3118.457 4.49 R L10 (Fragment) C7(Carbamidomethyl) VDEFPLCGHMVSDEYEQLSSEALEAA 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); I7HLV2 1 3134.460 3.34 R L10 (Fragment) C7(Carbamidomethyl); M10(Oxidation) C2 domain-containing N-Term(Dimethyl); K4(Dimethyl); VDGKLDSPSRSPSK Q80X80 1 1556.876 2.23 protein 2-like K14(Dimethyl) Galactose-3-O- N-Term(Dimethyl); M4(Oxidation); VDIMGYDLPSGGAGPTTEACLK P61315 1 2324.105 2.58 sulfotransferase 3 C20(Carbamidomethyl); K22(Dimethyl) Thiosulfate N-Term(Dimethyl); VDLSQPLIATCR P52196 9 1400.758 3.24 sulfurtransferase C11(Carbamidomethyl) Thiosulfate N-Term(Dimethyl:2H(6)13C(2)); VDLSQPLIATCR P52196 1 1408.798 2.37 sulfurtransferase C11(Carbamidomethyl) N-Term(Dimethyl); K12(Dimethyl); VDLTPNYGLTMKPGTCEHVQAWPR P00186 Cytochrome P450 1A2 1 2826.408 3.05 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VDLTPNYGLTMKPGTCEHVQAWPR P00186 Cytochrome P450 1A2 K12(HeavyDimethyl); 6 2842.491 3.47 C16(Carbamidomethyl) VDPVDGVVLVDPDYLK Q91YI4 Beta-arrestin-2 N-Term(Dimethyl); K16(Dimethyl) 1 1798.994 2.21 VDPVGPLSFSGGVSELAR Q6PNC0 DmX-like protein 1 N-Term(Dimethyl) 4 1814.961 2.24 Metallophosphoesterase VDPVPHDAPKPPGYTR F7BTE7 domain-containing N-Term(Dimethyl); K10(Dimethyl) 1 1801.948 2.30 protein 1 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); VDREPQDQETLGSDASEFSDTSMEDG Protein phosphatase 1 Q6A025 K34(HeavyDimethyl); 1 3968.956 3.21 GSATVSSKGLK regulatory subunit 26 K37(HeavyDimethyl) T-complex protein 1 N-Term(Dimethyl); K3(Dimethyl); VEKIPGGIIEDSCVLR E9Q133 5 1841.026 2.96 subunit gamma C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); T-complex protein 1 VEKIPGGIIEDSCVLR E9Q133 K3(HeavyDimethyl); 3 1857.106 2.96 subunit gamma C13(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); VELKGTVCAANDFNPDADAK F8WIT2 Annexin 1 2219.112 2.57 C8(Carbamidomethyl); K20(Dimethyl) C5(Carbamidomethyl); VELSCTGKVDSEVMILMQLNLTVNSS Tyrosine-protein kinase K8(HeavyDimethyl); H9H9R6 1 4067.217 3.05 KNFTVLNFK RYK K27(HeavyDimethyl); K35(HeavyDimethyl) Lysine-specific VESGDKETFIASEVEERR Q5NCY0 N-Term(Dimethyl); K6(Dimethyl) 1 2137.065 2.65 demethylase 6B DNA replication N-Term(Dimethyl:2H(6)13C(2)); VETPMPRLGAFFLER Q9CY94 complex GINS protein 1 1814.982 2.25 M5(Oxidation) PSF3 6-phosphofructokinase, N-Term(Dimethyl); VFANAPDSACVIGLR P12382 1 1617.828 2.56 liver type C10(Carbamidomethyl)

6-phosphofructokinase, N-Term(Dimethyl:2H(6)13C(2)); VFANAPDSACVIGLR P12382 1 1625.879 2.55 liver type C10(Carbamidomethyl)

N-Term(Dimethyl); VFANAYLSDLGGCIK P24549 Retinal dehydrogenase 1 8 1683.880 5.45 C13(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VFANAYLSDLGGCIK P24549 Retinal dehydrogenase 1 C13(Carbamidomethyl); 10 1699.963 5.54 K15(HeavyDimethyl) Microsomal glutathione N-Term(Dimethyl); VFANPEDCAGFGK D3YU60 12 1467.690 4.14 S-transferase 1 C8(Carbamidomethyl); K13(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Microsomal glutathione VFANPEDCAGFGK D3YU60 C8(Carbamidomethyl); 24 1483.777 4.23 S-transferase 1 K13(HeavyDimethyl) C8(Carbamidomethyl); Microsomal glutathione VFANPEDCAGFGKGENAK D3YU60 K13(HeavyDimethyl); 1 1983.019 2.36 S-transferase 1 K18(HeavyDimethyl) N-Term(Dimethyl); Microsomal glutathione VFANPEDCAGFGKGENAK D3YU60 C8(Carbamidomethyl); K13(Dimethyl); 40 1994.961 5.61 S-transferase 1 K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Microsomal glutathione C8(Carbamidomethyl); VFANPEDCAGFGKGENAK D3YU60 30 2019.089 5.61 S-transferase 1 K13(HeavyDimethyl); K18(HeavyDimethyl) N-Term(Dimethyl); Microsomal glutathione VFANPEDCAGFGKGENAKK D3YU60 C8(Carbamidomethyl); K13(Dimethyl); 6 2151.087 4.75 S-transferase 1 K18(Dimethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C8(Carbamidomethyl); Microsomal glutathione VFANPEDCAGFGKGENAKK D3YU60 K13(HeavyDimethyl); 12 2183.259 4.71 S-transferase 1 K18(HeavyDimethyl); K19(HeavyDimethyl) Leucine-rich PPR motif- N-Term(Dimethyl); VFESTCSSGSPGSNQALLLLR Q6PB66 containing protein, 2 2251.134 6.13 C6(Carbamidomethyl) mitochondrial Leucine-rich PPR motif- N-Term(Dimethyl:2H(6)13C(2)); VFESTCSSGSPGSNQALLLLR Q6PB66 containing protein, 1 2259.174 5.25 C6(Carbamidomethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); K4(Dimethyl); VFGKGNPTKVVAVDCGIK Q8C196 synthase [ammonia], K9(Dimethyl); C15(Carbamidomethyl); 10 2001.155 5.02 mitochondrial K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Carbamoyl-phosphate K4(HeavyDimethyl); VFGKGNPTKVVAVDCGIK Q8C196 synthase [ammonia], K9(HeavyDimethyl); 3 2033.322 4.38 mitochondrial C15(Carbamidomethyl); K18(HeavyDimethyl) Heat shock protein HSP N-Term(Dimethyl); VFIMDNCEELIPEYLNFIR P07901 4 2443.207 3.06 90-alpha C7(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl:2H(6)13C(2)); VFIMDNCEELIPEYLNFIR P07901 3 2451.266 3.32 90-alpha C7(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl); VFIMDSCDELIPEYLNFIR P11499 5 2402.199 4.22 90-beta C7(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl); M4(Oxidation); VFIMDSCDELIPEYLNFIR P11499 4 2418.184 3.74 90-beta C7(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl:2H(6)13C(2)); VFIMDSCDELIPEYLNFIR P11499 7 2410.228 5.15 90-beta C7(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl:2H(6)13C(2)); VFIMDSCDELIPEYLNFIR P11499 1 2426.230 3.13 90-beta M4(Oxidation); C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VFIWTCDDASGNMWSPK Q9D1M0 Protein SEC13 homolog C6(Carbamidomethyl); 1 2086.030 2.70 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); VFPPAANMEYMVWDENLAKSAEAWA Q8BS03 Peptidase inhibitor 15 M8(Oxidation); K19(HeavyDimethyl); 1 4598.244 2.85 ATCIWDHGPSYLLR C28(Carbamidomethyl) VFPPNTTQEQVYHACAMQIVKDVLAG Kinesin heavy chain C15(Carbamidomethyl); K21(Dimethyl); P33175 1 4547.263 3.29 YNGTIFAYGQTSSGK isoform 5A K41(Dimethyl) Isoform 3 of Electrogenic sodium VFQPMFNHSIFTSAVSPAAERIR O88343-3 2 2605.313 2.39 bicarbonate cotransporter 1 Aspartate N-Term(Dimethyl); VGAFTVVCK P05202 aminotransferase, 8 1036.582 2.88 C8(Carbamidomethyl); K9(Dimethyl) mitochondrial Aspartate N-Term(Dimethyl:2H(6)13C(2)); VGAFTVVCK P05202 aminotransferase, C8(Carbamidomethyl); 3 1052.674 2.27 mitochondrial K9(HeavyDimethyl) Aspartate N-Term(Dimethyl); VGAFTVVCKDAEEAK P05202 aminotransferase, C8(Carbamidomethyl); K9(Dimethyl); 12 1707.893 4.37 mitochondrial K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aspartate C8(Carbamidomethyl); VGAFTVVCKDAEEAK P05202 aminotransferase, 11 1732.027 4.16 K9(HeavyDimethyl); mitochondrial K15(HeavyDimethyl) VGAGAPVYMAAVLEYLTAEILELAGN F8WIX8 Histone H2A 2 2933.564 3.21 AAR Aldehyde N-Term(Dimethyl:2H(6)13C(2)); VGEALVSHPEVPLISFTGSQPTAERITQ Q8BH00 dehydrogenase family 8 C34(Carbamidomethyl); 1 3829.084 3.58 LSAPHCK member A1 K35(HeavyDimethyl) Sarcoplasmic/endoplasm N-Term(Dimethyl:2H(6)13C(2)); VGEATETALTCLVEK O55143 ic reticulum calcium C11(Carbamidomethyl); 2 1692.965 2.90 ATPase 2 K15(HeavyDimethyl) VGEVPLADSILCDGLTDAFHNYHMGIT Acetyl-Coenzyme A N-Term(Dimethyl); Q80X81 3 3613.803 4.16 AENVAK acetyltransferase 3 C12(Carbamidomethyl); K33(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VGEVPLADSILCDGLTDAFHNYHMGIT Acetyl-Coenzyme A Q80X81 C12(Carbamidomethyl); 2 3629.851 4.39 AENVAK acetyltransferase 3 K33(HeavyDimethyl) N-Term(Dimethyl); VGFGQCAGKVLPALSPA P35505 Fumarylacetoacetase 1 1727.952 2.28 C6(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VGFGQCAGKVLPALSPA P35505 Fumarylacetoacetase C6(Carbamidomethyl); 1 1744.040 2.26 K9(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); VGINTDTPDEALVVCGNMKVMGTVM Myelin regulatory factor- C15(Carbamidomethyl); Q3UN70 1 3434.740 3.00 HPSDSR like protein M18(Oxidation); K19(HeavyDimethyl); M21(Oxidation) Glycine receptor subunit VGLGITTVLTMTTQSSGSR Q5NCU0 N-Term(Dimethyl:2H(6)13C(2)) 1 1945.096 2.08 alpha-1 Aconitate hydratase, N-Term(Dimethyl); VGLIGSCTNSSYEDMGR Q99KI0 18 1873.837 5.24 mitochondrial C7(Carbamidomethyl) Aconitate hydratase, N-Term(Dimethyl); VGLIGSCTNSSYEDMGR Q99KI0 10 1889.830 4.02 mitochondrial C7(Carbamidomethyl); M15(Oxidation) Aconitate hydratase, N-Term(Dimethyl:2H(6)13C(2)); VGLIGSCTNSSYEDMGR Q99KI0 12 1881.872 5.11 mitochondrial C7(Carbamidomethyl) Aconitate hydratase, N-Term(Dimethyl:2H(6)13C(2)); VGLIGSCTNSSYEDMGR Q99KI0 5 1897.872 4.34 mitochondrial C7(Carbamidomethyl); M15(Oxidation) Aconitate hydratase, N-Term(Dimethyl); VGLIGSCTNSSYEDMGRSAAVAK Q99KI0 1 2429.181 3.59 mitochondrial C7(Carbamidomethyl); K23(Dimethyl) Isoform 2 of N- N-Term(Dimethyl); VGLSAVPADACSGAQK Q99KK2-2 acylneuraminate 1 1586.822 3.03 C11(Carbamidomethyl); K16(Dimethyl) cytidylyltransferase Isoform 2 of N- N-Term(Dimethyl:2H(6)13C(2)); VGLSAVPADACSGAQK Q99KK2-2 acylneuraminate C11(Carbamidomethyl); 2 1602.904 3.29 cytidylyltransferase K16(HeavyDimethyl) 60S ribosomal protein N-Term(Dimethyl); VGLTNYAAAYCTGLLLAR D3YYV8 4 1955.015 4.66 L5 (Fragment) C11(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); VGLTNYAAAYCTGLLLAR D3YYV8 7 1963.092 4.73 L5 (Fragment) C11(Carbamidomethyl) Retinitis pigmentosa 1- VGQASVFTAASGKGQDPR Q8CGM2 K13(Dimethyl) 1 1803.927 2.30 like 1 protein Alpha-2-HS- N-Term(Dimethyl); VGQPGAAGPVSPMCPGR P29699 8 1665.813 4.10 glycoprotein C14(Carbamidomethyl) Alpha-2-HS- N-Term(Dimethyl:2H(6)13C(2)); VGQPGAAGPVSPMCPGR P29699 6 1673.860 3.57 glycoprotein C14(Carbamidomethyl) Trifunctional enzyme VGSPPLEKFNIWGGSLSLGHPFGATGC N-Term(Dimethyl); K8(Dimethyl); Q99JY0 subunit beta, 3 2997.543 4.14 R C27(Carbamidomethyl) mitochondrial Trifunctional enzyme N-Term(Dimethyl:2H(6)13C(2)); VGSPPLEKFNIWGGSLSLGHPFGATGC Q99JY0 subunit beta, K8(HeavyDimethyl); 4 3013.633 3.64 R mitochondrial C27(Carbamidomethyl) Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); VGSVLQEGCEK Q8K2B3 [ubiquinone] C9(Carbamidomethyl); 3 1277.727 2.94 flavoprotein subunit, K11(HeavyDimethyl) mitochondrial Succinate dehydrogenase N-Term(Dimethyl); VGSVLQEGCEKISQLYGDLKHLK Q8K2B3 [ubiquinone] C9(Carbamidomethyl); K11(Dimethyl); 1 2713.504 2.96 flavoprotein subunit, K20(Dimethyl); K23(Dimethyl) mitochondrial Succinate N-Term(Dimethyl:2H(6)13C(2)); dehydrogenase C9(Carbamidomethyl); VGSVLQEGCEKISQLYGDLKHLK Q8K2B3 [ubiquinone] K11(HeavyDimethyl); 1 2745.668 3.17 flavoprotein subunit, K20(HeavyDimethyl); mitochondrial K23(HeavyDimethyl) 6-phosphogluconate N-Term(Dimethyl); VGTGEPCCDWVGDEGAGHFVK Q9DCD0 dehydrogenase, C7(Carbamidomethyl); 1 2333.027 2.67 decarboxylating C8(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 6-phosphogluconate C7(Carbamidomethyl); VGTGEPCCDWVGDEGAGHFVK Q9DCD0 dehydrogenase, 1 2349.117 2.26 C8(Carbamidomethyl); decarboxylating K21(HeavyDimethyl) Leucine-rich PPR motif- N-Term(Dimethyl); VGVDPDQETYINYVFPCFDSAQSVR Q6PB66 containing protein, 3 2934.376 4.06 C17(Carbamidomethyl) mitochondrial Leucine-rich PPR motif- N-Term(Dimethyl:2H(6)13C(2)); VGVDPDQETYINYVFPCFDSAQSVR Q6PB66 containing protein, 1 2942.407 3.63 C17(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Hydroxymethylglutaryl- K18(HeavyDimethyl); VGVFSYGSGLAATLYSLKVTQDATPG Q8JZK9 CoA synthase, K31(HeavyDimethyl); 1 4262.449 3.38 SALDKITASLCDLK cytoplasmic C37(Carbamidomethyl); K40(HeavyDimethyl) 3-ketoacyl-CoA thiolase, VGVPTETGALTLNR Q8BWT1 N-Term(Dimethyl:2H(6)13C(2)) 1 1463.864 1.95 mitochondrial N-Term(Dimethyl:2H(6)13C(2)); C16(Carbamidomethyl); VGVPTETGALTLNRLCGSGFQSIVSGC 3-ketoacyl-CoA thiolase, Q8BWT1 C27(Carbamidomethyl); 2 3597.880 5.04 QEICSK mitochondrial C31(Carbamidomethyl); K33(HeavyDimethyl) Glyoxylate N-Term(Dimethyl:2H(6)13C(2)); VGYTPGVLTDATAELAVSLLLTTCR Q91Z53 reductase/hydroxypyruv 2 2657.472 3.07 C24(Carbamidomethyl) ate reductase N-Term(Dimethyl); VHACGVNPVETYIR P47199 Quinone oxidoreductase 4 1642.836 2.77 C4(Carbamidomethyl) N-Term(Dimethyl); K6(Dimethyl); C7(Carbamidomethyl); VHITEKCYECNECGK G3X9I0 Protein Zfp105 1 2010.903 2.32 C10(Carbamidomethyl); C13(Carbamidomethyl); K15(Dimethyl) NADPH--cytochrome N-Term(Dimethyl); VHPNSVHICAVAVEYEAK P37040 1 2079.064 2.43 P450 reductase C9(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); NADPH--cytochrome VHPNSVHICAVAVEYEAK P37040 C9(Carbamidomethyl); 2 2095.149 2.80 P450 reductase K18(HeavyDimethyl) Isoform 2 of S100P- VIAHIEDPGDSNQGNMATKEWLIK Q9D5K4-2 K19(Dimethyl); K24(Dimethyl) 10 2722.362 3.23 binding protein 4- N-Term(Dimethyl); VIATFACSGEKEVNLAVENAK Q9JLJ2 trimethylaminobutyralde C7(Carbamidomethyl); K11(Dimethyl); 3 2334.236 6.39 hyde dehydrogenase K21(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 4- C7(Carbamidomethyl); VIATFACSGEKEVNLAVENAK Q9JLJ2 trimethylaminobutyralde 1 2358.368 2.43 K11(HeavyDimethyl); hyde dehydrogenase K21(HeavyDimethyl) Isoform 2 of Rab GDP N-Term(Dimethyl); VICILSHPIKNTNDANSCQIIIPQNQVNR Q61598-2 dissociation inhibitor C3(Carbamidomethyl); K10(Dimethyl); 1 3415.809 4.81 beta C18(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Rab GDP C3(Carbamidomethyl); VICILSHPIKNTNDANSCQIIIPQNQVNR Q61598-2 dissociation inhibitor 1 3431.880 3.03 K10(HeavyDimethyl); beta C18(Carbamidomethyl) Isoform 2 of Spectrin VIESTQDLGNDLAGVMALQRKLTGME Q62261-2 beta chain, non- K21(HeavyDimethyl); M25(Oxidation) 1 2997.588 2.92 R erythrocytic 1 VIGQSKHPSLADRDSMPYTNAVVHEIL Protein Cyp2j13 F6R6R4 K6(HeavyDimethyl) 1 3169.658 2.69 R (Fragment) L-lactate dehydrogenase N-Term(Dimethyl); VIGSGCNLDSAR P06151 8 1276.626 4.04 A chain C6(Carbamidomethyl)

L-lactate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); VIGSGCNLDSAR P06151 7 1284.672 3.72 A chain C6(Carbamidomethyl) Isoform Peroxisomal of Serine--pyruvate N-Term(Dimethyl); VIHHTTPVTSLYCLR O35423-2 1 1824.973 2.18 aminotransferase, C13(Carbamidomethyl) mitochondrial Isoform Peroxisomal of Serine--pyruvate N-Term(Dimethyl:2H(6)13C(2)); VIHHTTPVTSLYCLR O35423-2 1 1833.017 2.25 aminotransferase, C13(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Glyceraldehyde-3- K21(HeavyDimethyl); VIISAPSADAPMFVMGVNHEKYDNSL phosphate K27(HeavyDimethyl); S4R257 1 4878.652 3.37 KIVSNASCTTNCLAPLAK dehydrogenase C34(Carbamidomethyl); (Fragment) C38(Carbamidomethyl); K44(HeavyDimethyl) VIITEIDPINALQAAMEGYEVTTMDEA Adenosylhomocysteinas N-Term(Dimethyl); P50247 9 3281.596 5.74 CK e C28(Carbamidomethyl); K29(Dimethyl)

VIITEIDPINALQAAMEGYEVTTMDEA Adenosylhomocysteinas N-Term(Dimethyl); M24(Oxidation); P50247 3 3297.588 6.06 CK e C28(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VIITEIDPINALQAAMEGYEVTTMDEA Adenosylhomocysteinas P50247 C28(Carbamidomethyl); 5 3297.698 5.17 CK e K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); VIITEIDPINALQAAMEGYEVTTMDEA Adenosylhomocysteinas M24(Oxidation); P50247 1 3313.685 3.55 CK e C28(Carbamidomethyl); K29(HeavyDimethyl) VIIVGLDNAGKTTILYQFSMNEVVHTS ADP-ribosylation factor- N-Term(Dimethyl); K11(Dimethyl); Q80ZU0 1 4744.540 3.39 PTIGSNVEEIVVNNTR like protein 5A M20(Oxidation) Isoform 2a of Neurexin- N-Term(Dimethyl:2H(6)13C(2)); VIMPMVMHTEAEDVSFRFMSQR Q6P9K9-2 1 2693.339 2.57 3 M19(Oxidation) Peptidyl-prolyl cis-trans N-Term(Dimethyl); VIPAFMCQAGDFTNHNGTGGR Q99KR7 isomerase F, 3 2278.051 3.37 C7(Carbamidomethyl) mitochondrial Peptidyl-prolyl cis-trans N-Term(Dimethyl:2H(6)13C(2)); VIPAFMCQAGDFTNHNGTGGR Q99KR7 isomerase F, 1 2286.082 2.74 C7(Carbamidomethyl) mitochondrial N-Term(Dimethyl); Alcohol dehydrogenase VIPLFSPQCGECR P00329 C9(Carbamidomethyl); 23 1590.773 3.37 1 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alcohol dehydrogenase VIPLFSPQCGECR P00329 C9(Carbamidomethyl); 18 1598.815 3.48 1 C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VIQCFAETGQVQK Q68FD5 Clathrin heavy chain 1 C4(Carbamidomethyl); 1 1579.890 1.98 K13(HeavyDimethyl) 2-amino-3- carboxymuconate-6- N-Term(Dimethyl); VIQQNCWDPEVR Q8R519 2 1571.757 2.57 semialdehyde C6(Carbamidomethyl) decarboxylase N-Term(Dimethyl:2H(6)13C(2)); Bile acyl-CoA VIQVSNVLSFCGCR Q4LDG0 C11(Carbamidomethyl); 3 1674.888 2.80 synthetase C13(Carbamidomethyl) VITAFNDGLNHLDSLKGTFASLSELHC N-Term(Dimethyl); K16(Dimethyl); A8DUK4 Beta-globin 1 4394.239 3.55 DKLHVDPENFR C27(Carbamidomethyl); K29(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VITAFNDGLNHLDSLKGTFASLSELHC K16(HeavyDimethyl); A8DUK4 Beta-globin 1 4418.369 3.93 DKLHVDPENFR C27(Carbamidomethyl); K29(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); K11(HeavyDimethyl); VITSGFNALEKILQSTAGKYCVGDEVS Maleylacetoacetate Q9WVL0 K19(HeavyDimethyl); 1 4648.491 4.23 MADVCLVPQVANAER isomerase C21(Carbamidomethyl); C32(Carbamidomethyl) NADH dehydrogenase [ubiquinone] 1 alpha N-Term(Dimethyl); VITVDGNICSGK Q99LC3 3 1318.703 2.37 subcomplex subunit 10, C9(Carbamidomethyl); K12(Dimethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); [ubiquinone] 1 alpha VITVDGNICSGK Q99LC3 C9(Carbamidomethyl); 1 1334.788 1.93 subcomplex subunit 10, K12(HeavyDimethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl); [ubiquinone] 1 alpha VITVDGNICSGKNK Q99LC3 C9(Carbamidomethyl); K12(Dimethyl); 1 1588.872 2.20 subcomplex subunit 10, K14(Dimethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); [ubiquinone] 1 alpha C9(Carbamidomethyl); VITVDGNICSGKNK Q99LC3 1 1613.004 2.17 subcomplex subunit 10, K12(HeavyDimethyl); mitochondrial K14(HeavyDimethyl)

Malate dehydrogenase, N-Term(Dimethyl); VIVVGNPANTNCLTASK P14152 26 1813.976 5.61 cytoplasmic C12(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Malate dehydrogenase, VIVVGNPANTNCLTASK P14152 C12(Carbamidomethyl); 36 1830.064 6.17 cytoplasmic K17(HeavyDimethyl) Isoform 2 of Cyclic AMP-responsive VKARPPGQIRGMVHTDEM Q9D2A5-2 K2(HeavyDimethyl); M18(Oxidation) 1 2074.099 2.36 element-binding protein 3-like protein 4 N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); VKAVLTSQETLFGGSDCTGNFCLFK Q921I1 Serotransferrin C17(Carbamidomethyl); 1 2887.575 3.17 C22(Carbamidomethyl); K25(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); C3(Carbamidomethyl); Baculoviral IAP repeat- VKCFCCGLMLDNWKQGDSPVEK Q62210 C5(Carbamidomethyl); 1 2799.302 2.88 containing protein 2 C6(Carbamidomethyl); M9(Oxidation); K14(Dimethyl); K22(Dimethyl) Glutathione S- N-Term(Dimethyl); K2(Dimethyl); VKDCPPADLIIK D3Z3X5 1 1452.862 2.45 transferase theta-1 C4(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutathione S- K2(HeavyDimethyl); VKDCPPADLIIK D3Z3X5 4 1476.982 2.71 transferase theta-1 C4(Carbamidomethyl); K12(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); Glutathione S- VKDCPPADLIIKQK D3Z3X5 C4(Carbamidomethyl); K12(Dimethyl); 5 1737.027 3.33 transferase theta-1 K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Glutathione S- VKDCPPADLIIKQK D3Z3X5 C4(Carbamidomethyl); 1 1769.212 2.74 transferase theta-1 K12(HeavyDimethyl); K14(HeavyDimethyl) Transmembrane protein N-Term(Dimethyl); K2(Dimethyl); VKFATFTIPPEESCPTVNSILSGEDDIK Q8CEF9 1 3178.611 2.37 132C C14(Carbamidomethyl); K28(Dimethyl) K2(HeavyDimethyl); T-box transcription VKGMDPVKQYYVILDVVPVDSK Q8K402 K8(HeavyDimethyl); 1 2600.606 2.51 factor TBX22 K22(HeavyDimethyl) UDP- N-Term(Dimethyl); K2(Dimethyl); VKNVLLAVSENFMCR Q63886 glucuronosyltransferase 2 1835.988 2.56 C14(Carbamidomethyl) 1-1 UDP- N-Term(Dimethyl:2H(6)13C(2)); VKNVLLAVSENFMCR Q63886 glucuronosyltransferase K2(HeavyDimethyl); 2 1852.069 3.49 1-1 C14(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); VKPDKSGVVTDGVKHSMNPFCEIAVE Electron transfer Q9DCW4 K5(Dimethyl); K14(Dimethyl); 9 3410.775 5.17 EAVR flavoprotein subunit beta C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); VKPDKSGVVTDGVKHSMNPFCEIAVE Electron transfer Q9DCW4 K5(HeavyDimethyl); 1 3442.959 4.10 EAVR flavoprotein subunit beta K14(HeavyDimethyl); C21(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); Long-chain-fatty-acid-- VKPKPPEPEDLAIICFTSGTTGNPK D3Z041 K4(Dimethyl); C15(Carbamidomethyl); 10 2808.516 5.69 CoA ligase 1 K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Long-chain-fatty-acid-- VKPKPPEPEDLAIICFTSGTTGNPK D3Z041 K4(HeavyDimethyl); 7 2840.689 4.74 CoA ligase 1 C15(Carbamidomethyl); K25(HeavyDimethyl) VKVGNEYVTKGQTVQQVYNAVGALA N-Term(Dimethyl); K2(Dimethyl); P13542 Myosin-8 1 2876.622 2.77 K K10(Dimethyl); K26(Dimethyl) N-Term(Dimethyl); VLAACLTEKGAEELR Q6PHA1 Protein Rdh9 7 1715.930 3.57 C5(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VLAACLTEKGAEELR Q6PHA1 Protein Rdh9 C5(Carbamidomethyl); 2 1732.021 3.54 K9(HeavyDimethyl) N-Term(Dimethyl); VLAACLTEKGAEQLR O88451 Retinol dehydrogenase 7 7 1714.944 4.98 C5(Carbamidomethyl); K9(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VLAACLTEKGAEQLR O88451 Retinol dehydrogenase 7 C5(Carbamidomethyl); 9 1731.038 4.90 K9(HeavyDimethyl) Isoform 3 of VLAFGAKPESSLHTYFPSFLSR Q8BM55-3 Transmembrane protein N-Term(Dimethyl); K7(Dimethyl) 1 2510.342 2.38 214 Alanine N-Term(Dimethyl); VLCIINPGNPTGQVQSR Q8BGT5 9 1880.996 4.72 aminotransferase 2 C3(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); VLCIINPGNPTGQVQSR Q8BGT5 11 1889.040 5.11 aminotransferase 2 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Alanine VLCIINPGNPTGQVQSRK Q8BGT5 C3(Carbamidomethyl); 2 2053.222 2.54 aminotransferase 2 K18(HeavyDimethyl) Alanine N-Term(Dimethyl); VLCVINPGNPTGQVQTR Q8QZR5 11 1881.000 5.35 aminotransferase 1 C3(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); VLCVINPGNPTGQVQTR Q8QZR5 9 1889.040 5.48 aminotransferase 1 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of V-type C8(Carbamidomethyl); VLDALFPCVQGGTTAIPGAFGCGK P50516-2 proton ATPase catalytic 1 2508.366 2.73 C22(Carbamidomethyl); subunit A K24(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); VLDFHHPHQLLEGMEGFNLELSDHPES Glutamate D3Z1L8 C35(Carbamidomethyl); 1 4783.448 2.73 LEQILVDCRDTLK decarboxylase 1 K40(HeavyDimethyl) N-Term(Dimethyl); VLDVACGTGVDSIMLVEEGFSVMSVD Glycine N- Q9QXF8 C6(Carbamidomethyl); K30(Dimethyl); 3 3586.780 4.06 ASDKMLK methyltransferase K33(Dimethyl) Serine N-Term(Dimethyl); VLEACSIACNK G3UZ26 hydroxymethyltransferas C5(Carbamidomethyl); 2 1320.661 2.33 e (Fragment) C9(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Serine C5(Carbamidomethyl); VLEACSIACNK G3UZ26 hydroxymethyltransferas 1 1336.750 2.25 C9(Carbamidomethyl); e (Fragment) K11(HeavyDimethyl)

N-Term(Dimethyl); Serine C5(Carbamidomethyl); VLEACSIACNKNTCPGDKSALRPSGLR G3UZ26 hydroxymethyltransferas 1 3058.562 3.08 C9(Carbamidomethyl); K11(Dimethyl); e (Fragment) C14(Carbamidomethyl); K18(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); Serine C9(Carbamidomethyl); VLEACSIACNKNTCPGDKSALRPSGLR G3UZ26 hydroxymethyltransferas 1 3082.684 3.58 K11(HeavyDimethyl); e (Fragment) C14(Carbamidomethyl); K18(HeavyDimethyl) Serine N-Term(Dimethyl); K11(Dimethyl); VLELVSITANKNTCPGDR Q9CZN7 hydroxymethyltransferas 9 2043.090 4.81 C14(Carbamidomethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); VLELVSITANKNTCPGDR Q9CZN7 hydroxymethyltransferas K11(HeavyDimethyl); 4 2059.172 4.92 e C14(Carbamidomethyl) Serine N-Term(Dimethyl); K11(Dimethyl); VLELVSITANKNTCPGDRSAITPGGLR Q9CZN7 hydroxymethyltransferas 2 2895.567 3.34 C14(Carbamidomethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); VLELVSITANKNTCPGDRSAITPGGLR Q9CZN7 hydroxymethyltransferas K11(HeavyDimethyl); 4 2911.657 3.74 e C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Methyltransferase-like VLEPTWKHIGDGCHLTR Q9DD20 K7(HeavyDimethyl); 1 2091.182 2.68 protein 7B C13(Carbamidomethyl) VLEVASGSGQHAAHFAQAFPNAEWQP N-Term(Dimethyl:2H(6)13C(2)); E9Q7K5 Protein 0610011F06Rik 1 4574.265 3.96 SDVDQRCLDSIAATTR C33(Carbamidomethyl) 39S ribosomal protein N-Term(Dimethyl); VLGCGARGLGADPGLERR D3Z456 1 1882.027 2.27 L3, mitochondrial C4(Carbamidomethyl) Beta-lactamase-like N-Term(Dimethyl); VLGCNPGPMTLQGTNTYLVGTGSR Q99KR3 4 2521.256 5.25 protein 2 C4(Carbamidomethyl) Beta-lactamase-like N-Term(Dimethyl); VLGCNPGPMTLQGTNTYLVGTGSR Q99KR3 1 2537.252 5.16 protein 2 C4(Carbamidomethyl); M9(Oxidation) Beta-lactamase-like N-Term(Dimethyl:2H(6)13C(2)); VLGCNPGPMTLQGTNTYLVGTGSR Q99KR3 2 2529.299 5.14 protein 2 C4(Carbamidomethyl) Beta-lactamase-like N-Term(Dimethyl:2H(6)13C(2)); VLGCNPGPMTLQGTNTYLVGTGSR Q99KR3 2 2545.288 3.41 protein 2 C4(Carbamidomethyl); M9(Oxidation) Methylcrotonoyl-CoA N-Term(Dimethyl); VLGDLSSEDGCTYLK Q99MR8 carboxylase subunit 1 1712.835 3.02 C11(Carbamidomethyl); K15(Dimethyl) alpha, mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); VLGDLSSEDGCTYLK Q99MR8 carboxylase subunit C11(Carbamidomethyl); 3 1728.931 3.35 alpha, mitochondrial K15(HeavyDimethyl) N-Term(Dimethyl); K8(Dimethyl); VLGEDSSKNVFFSSSSMFSSLALILMGA I7HJI3 Protein Serpinb6e M17(Oxidation); M26(Oxidation); 1 4683.383 3.32 NGTTASQISQVLSLDK K44(Dimethyl) Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); VLGTSVESIMATEDR Q8C196 synthase [ammonia], 2 1659.865 2.66 M10(Oxidation) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl); VLIANRGEIACR Q99MR8 carboxylase subunit 2 1399.778 2.39 C11(Carbamidomethyl) alpha, mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); VLIANRGEIACR Q99MR8 carboxylase subunit 2 1407.824 2.70 C11(Carbamidomethyl) alpha, mitochondrial Trifunctional enzyme VLKEVESVTPEHCIFASNTSALPINQIA N-Term(Dimethyl); K3(Dimethyl); Q8BMS1 subunit alpha, 1 3536.912 4.81 AVSK C13(Carbamidomethyl); K32(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); Trifunctional enzyme VLKEVESVTPEHCIFASNTSALPINQIA K3(HeavyDimethyl); Q8BMS1 subunit alpha, 1 3561.052 4.52 AVSK C13(Carbamidomethyl); mitochondrial K32(HeavyDimethyl) 3 beta-hydroxysteroid N-Term(Dimethyl); K3(Dimethyl); VLKGDILDAQCLK Q61694 1 1556.907 2.46 dehydrogenase type 5 C11(Carbamidomethyl); K13(Dimethyl) C4(Carbamidomethyl); VLLCFSNGNHYDIVYPITYKDSSAMCQ OTU domain-containing K20(HeavyDimethyl); M25(Oxidation); B2RRE7 1 4535.341 3.32 SLLYELLYEK protein 4 C26(Carbamidomethyl); K37(HeavyDimethyl) N-Term(Dimethyl); M8(Oxidation); VLLVLMFMTLLHFDASFFSIIQNIVGTA Q64310 Surfeit locus protein 4 M30(Oxidation); K38(Dimethyl); 1 4571.634 2.81 LMILVAIGFKTK K40(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Clustered C12(Carbamidomethyl); VLNDRDEEVELCSSVECK Q5SW19-2 mitochondria protein 4 2253.133 3.14 C17(Carbamidomethyl); homolog K18(HeavyDimethyl) Serum VLNFDTLVDNISVDPVTGDLWVGCHP N-Term(Dimethyl); H3BK03 paraoxonase/arylesterase 1 3368.671 5.46 NGMR C24(Carbamidomethyl) 1 (Fragment) Serum VLNFDTLVDNISVDPVTGDLWVGCHP N-Term(Dimethyl); H3BK03 paraoxonase/arylesterase 1 3384.624 2.88 NGMR C24(Carbamidomethyl); M29(Oxidation) 1 (Fragment) Serum VLNFDTLVDNISVDPVTGDLWVGCHP N-Term(Dimethyl:2H(6)13C(2)); H3BK03 paraoxonase/arylesterase 6 3376.715 4.47 NGMR C24(Carbamidomethyl) 1 (Fragment) Serum VLNFDTLVDNISVDPVTGDLWVGCHP N-Term(Dimethyl:2H(6)13C(2)); H3BK03 paraoxonase/arylesterase 1 3392.703 2.67 NGMR C24(Carbamidomethyl); M29(Oxidation) 1 (Fragment) Ornithine N-Term(Dimethyl); VLPMNTGVEAGETACK P29758 aminotransferase, 5 1732.855 3.29 C15(Carbamidomethyl); K16(Dimethyl) mitochondrial Ornithine N-Term(Dimethyl:2H(6)13C(2)); VLPMNTGVEAGETACK P29758 aminotransferase, C15(Carbamidomethyl); 7 1748.941 3.96 mitochondrial K16(HeavyDimethyl) Ornithine N-Term(Dimethyl:2H(6)13C(2)); VLPMNTGVEAGETACK P29758 aminotransferase, M4(Oxidation); C15(Carbamidomethyl); 1 1764.936 2.60 mitochondrial K16(HeavyDimethyl) VLQNLCDLYALNGILTNSGDFLHDGFL Peroxisomal acyl- N-Term(Dimethyl); Q9QXD1 1 3965.969 3.41 SGAQVDMAR coenzyme A oxidase 2 C6(Carbamidomethyl) VLQNLCDLYALNGILTNSGDFLHDGFL Peroxisomal acyl- N-Term(Dimethyl:2H(6)13C(2)); Q9QXD1 1 3974.011 4.73 SGAQVDMAR coenzyme A oxidase 2 C6(Carbamidomethyl) GTP cyclohydrolase 1 N-Term(Dimethyl:2H(6)13C(2)); VLSMTGVGQTLVWCLHKE P99025 feedback regulatory C14(Carbamidomethyl); 1 2130.213 2.52 protein K17(HeavyDimethyl) DmX-like protein 2 VLSSHLMHSSLPGLTR F6RYL8 M7(Oxidation) 1 1750.935 2.50 (Fragment) M12(Oxidation); VLSVIYTVVTPMCNPVIYCLRNR Q8VGH5 Olfactory receptor C13(Carbamidomethyl); 1 2783.404 2.75 C19(Carbamidomethyl) Alanine N-Term(Dimethyl); VLTLDTMNPCVR Q8QZR5 10 1446.735 3.72 aminotransferase 1 C10(Carbamidomethyl) Alanine N-Term(Dimethyl); M7(Oxidation); VLTLDTMNPCVR Q8QZR5 2 1462.735 2.97 aminotransferase 1 C10(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); VLTLDTMNPCVR Q8QZR5 14 1454.788 3.65 aminotransferase 1 C10(Carbamidomethyl) Alanine N-Term(Dimethyl:2H(6)13C(2)); VLTLDTMNPCVR Q8QZR5 4 1470.778 2.59 aminotransferase 1 M7(Oxidation); C10(Carbamidomethyl)

Electron transfer N-Term(Dimethyl); K10(Dimethyl); VLVAQHDAYKGLLPEELTPLILETQKQ Q99LC5 flavoprotein subunit K26(Dimethyl); C34(Carbamidomethyl); 1 4756.534 3.24 FSYTHICAGASAFGK alpha, mitochondrial K42(Dimethyl) N-Term(Dimethyl); VLVCGAGPVGMVTLLVAK Q64442 Sorbitol dehydrogenase 11 1840.075 4.54 C4(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VLVCGAGPVGMVTLLVAK Q64442 Sorbitol dehydrogenase C4(Carbamidomethyl); 18 1856.169 4.74 K18(HeavyDimethyl) VMGDIPVELINEVMSTITDPAGMLGPE Histone acetyltransferase N-Term(Dimethyl); M2(Oxidation); F6ZCH1 1 3737.821 2.85 FCLSEVN KAT2B (Fragment) M14(Oxidation); C29(Carbamidomethyl) VMGGYDFPGSNSNIDLHALTGWIPERI N-Term(Dimethyl:2H(6)13C(2)); F2Z3X0 Calpain-7 1 4267.147 2.62 AMHSDSQTFSK M2(Oxidation); K38(HeavyDimethyl) VMHGGANITGFQIVNNENPMVQQFIQ N-Term(Dimethyl:2H(6)13C(2)); F2Z488 Glutamate receptor 3 1 3094.568 2.50 R M20(Oxidation) VMHNDTGFYTLR E9Q7W7 Protein Gm5155 N-Term(Dimethyl); M2(Oxidation) 1 1497.727 2.38 N-Term(Dimethyl); K4(Dimethyl); VMIKCDPNDQNP Q64442 Sorbitol dehydrogenase 12 1486.699 3.65 C5(Carbamidomethyl) N-Term(Dimethyl); M2(Oxidation); VMIKCDPNDQNP Q64442 Sorbitol dehydrogenase 9 1502.692 3.33 K4(Dimethyl); C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VMIKCDPNDQNP Q64442 Sorbitol dehydrogenase K4(HeavyDimethyl); 14 1502.787 3.23 C5(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VMIKCDPNDQNP Q64442 Sorbitol dehydrogenase M2(Oxidation); K4(HeavyDimethyl); 3 1518.779 2.98 C5(Carbamidomethyl) Nucleoside diphosphate N-Term(Dimethyl); K12(Dimethyl); VMLGETNPADSKPGTIRGDFCIQVGR Q5NC80 1 2874.449 2.86 kinase (Fragment) C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Nucleoside diphosphate VMLGETNPADSKPGTIRGDFCIQVGR Q5NC80 K12(HeavyDimethyl); 1 2890.554 2.59 kinase (Fragment) C21(Carbamidomethyl) Blood vessel epicardial VMLSLGCTLYVVWATLYR Q9ES83 M2(Oxidation); C7(Carbamidomethyl) 2 2161.101 2.53 substance VMSELFLHTPSDSGVSFQTISSMSDFW Polycystic kidney N-Term(Dimethyl); M23(Oxidation); A2A259 1 4842.325 2.84 DFAQGPLLDSLYWTK disease 2-like 1 protein K42(Dimethyl) Interleukin-22 receptor N-Term(Dimethyl); VMTACAGRHSAWTRTPR Q80XF5 2 1985.971 2.59 subunit alpha-2 C5(Carbamidomethyl) Poly(rC)-binding protein N-Term(Dimethyl); VMTIPYQPMPASSPVICAGGQDR P60335 1 2503.231 2.41 1 C17(Carbamidomethyl) Poly(rC)-binding protein N-Term(Dimethyl:2H(6)13C(2)); VMTIPYQPMPASSPVICAGGQDR P60335 2 2511.252 3.56 1 C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VMVVLTDGDIFGDPLNLTTVINSPKMQ Q8BS01 Integrin alpha-E M2(Oxidation); K25(HeavyDimethyl); 1 4458.534 3.02 GVVRFAIGVGDAFK K41(HeavyDimethyl) Dehydrogenase/reductas N-Term(Dimethyl); VNCLAPGLIK Q99LB2 1 1140.682 2.28 e SDR family member 4 C3(Carbamidomethyl); K10(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Dehydrogenase/reductas VNCLAPGLIK Q99LB2 C3(Carbamidomethyl); 7 1156.765 2.83 e SDR family member 4 K10(HeavyDimethyl) N-Term(Dimethyl); C6(Carbamidomethyl); VNDGVCDCCDGTDEYNSGTVCENTCR Glucosidase 2 subunit C8(Carbamidomethyl); O08795 1 3370.289 3.34 EK beta C9(Carbamidomethyl); C21(Carbamidomethyl); C25(Carbamidomethyl); K28(Dimethyl) Betaine--homocysteine S- VNEAACDIAR O35490 C6(Carbamidomethyl) 2 1118.526 2.68 methyltransferase 1

Betaine--homocysteine S-N-Term(Dimethyl); VNEAACDIAR O35490 12 1146.554 3.40 methyltransferase 1 C6(Carbamidomethyl)

Betaine--homocysteine S-N-Term(Dimethyl:2H(6)13C(2)); VNEAACDIAR O35490 8 1154.598 3.52 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); Pre-mRNA-splicing VNFKQVDDLASVWCQCGELELR Q9DCD2 C14(Carbamidomethyl); 1 2722.356 2.76 factor SYF1 C16(Carbamidomethyl) VNGRPLADSSELQEAVLNESSLLLEVR Q9D236 Serine protease HTRA3 1 2938.525 2.84 Acetyl-Coenzyme A N-Term(Dimethyl); VNINGGAIALGHPLGASGCR Q80X81 1 1962.037 2.96 acetyltransferase 3 C19(Carbamidomethyl) N-Term(Dimethyl); K3(Dimethyl); C5(Carbamidomethyl); VNKECCHGDLLECADDRAELAK P07724 Serum albumin 12 2687.250 4.10 C6(Carbamidomethyl); C13(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K3(HeavyDimethyl); C5(Carbamidomethyl); VNKECCHGDLLECADDRAELAK P07724 Serum albumin 10 2711.382 4.81 C6(Carbamidomethyl); C13(Carbamidomethyl); K22(HeavyDimethyl) VNLVMYFFLYEEEFDPFFRYEIPATHL Isoform 2 of F-box/LRR- Q8C4V4-2 N-Term(Dimethyl) 1 3980.891 3.22 YFGR repeat protein 3 40S ribosomal protein N-Term(Dimethyl); VNQAIWLLCTGAR D3YYM6 6 1529.821 2.78 S5 (Fragment) C9(Carbamidomethyl) 40S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); VNQAIWLLCTGAR D3YYM6 1 1537.872 2.90 S5 (Fragment) C9(Carbamidomethyl) N-Term(Dimethyl); VNQIGSVTESIQACK Q6PHC1 Alpha-enolase 36 1689.877 5.15 C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VNQIGSVTESIQACK Q6PHC1 Alpha-enolase C14(Carbamidomethyl); 14 1705.963 4.99 K15(HeavyDimethyl) N-Term(Dimethyl); VNQIGSVTESLQACK Q6PHC1 Alpha-enolase 38 1689.876 5.28 C14(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VNQIGSVTESLQACK Q6PHC1 Alpha-enolase C14(Carbamidomethyl); 18 1705.966 5.51 K15(HeavyDimethyl) VNSSEVCYDQESMLSSHLPSPGNIRKSS N-Term(Dimethyl); Q6IE82 Protein Jade-3 1 3951.899 2.83 MEHFSR C7(Carbamidomethyl); K26(Dimethyl) VPAARPMPQPPPAAPPRVYQPPTYNRII Angiopoietin-related Q9R045 K43(Dimethyl) 1 4835.558 3.21 NQISTNEIQSDQNLK protein 2 Endoplasmic reticulum- VPGNFHVSTHSATAQPQNPDMTHTIH Q9DC16 Golgi intermediate N-Term(Dimethyl); K27(Dimethyl) 1 3008.515 2.77 K compartment protein 1 N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Solute VPLLENFYADYYTMASIALASCLAMC C22(Carbamidomethyl); Q3UHH2-2 carrier family 22 1 4128.246 2.87 LVVKFLGRR C26(Carbamidomethyl); member 23 K30(HeavyDimethyl) Methylmalonate- semialdehyde N-Term(Dimethyl); K6(Dimethyl); VPQSTKAEMDAAVESCKR Q9EQ20 dehydrogenase 1 2091.052 2.65 C16(Carbamidomethyl); K17(Dimethyl) [acylating], mitochondrial VPRPSSSYHTWVSLRPGSGALNSVGR A2AJ76 Hemicentin-2 N-Term(Dimethyl) 1 2795.452 2.58 PQ-loop repeat- VQDSGAVSALTWGLSAYTCATR Q8C6U2 C19(Carbamidomethyl) 1 2314.138 2.56 containing protein 3 N-Term(Dimethyl); VQEEAQCLVEELR Q3UT49 Cytochrome P450 2C29 4 1630.805 3.30 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VQEEAQCLVEELR Q3UT49 Cytochrome P450 2C29 4 1638.850 3.69 C7(Carbamidomethyl) N-Term(Dimethyl); VQEEAQCLVEELRK Q3UT49 Cytochrome P450 2C29 2 1786.937 2.51 C7(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VQEEAQCLVEELRK Q3UT49 Cytochrome P450 2C29 C7(Carbamidomethyl); 3 1803.022 2.57 K14(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); VQELSLSAPLTVLPTVTCEDTIAILR Q91WT9-2 Cystathionine beta- 3 2867.596 3.55 C18(Carbamidomethyl) synthase Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); VQELSLSAPLTVLPTVTCEDTIAILR Q91WT9-2 Cystathionine beta- 3 2875.650 3.50 C18(Carbamidomethyl) synthase Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); VQELSLSAPLTVLPTVTCEDTIAILREK Q91WT9-2 Cystathionine beta- C18(Carbamidomethyl); 1 3168.847 3.01 synthase K28(HeavyDimethyl) E3 ubiquitin-protein N-Term(Dimethyl); M4(Oxidation); VQEMTSSLCLLPDQR Q9CWS1 2 1820.879 2.38 ligase RNF135 C9(Carbamidomethyl) Sterol-4-alpha- carboxylate 3- N-Term(Dimethyl); VQFFIGDLCNQQDLYPALK Q9R1J0 2 2325.203 3.38 dehydrogenase, C9(Carbamidomethyl); K19(Dimethyl) decarboxylating Sterol-4-alpha- N-Term(Dimethyl:2H(6)13C(2)); carboxylate 3- VQFFIGDLCNQQDLYPALK Q9R1J0 C9(Carbamidomethyl); 1 2341.286 3.59 dehydrogenase, K19(HeavyDimethyl) decarboxylating N-Term(Dimethyl); VQLLDYVISSFYPEIQAAHTCDTDNIQR Q9DBC0 Selenoprotein O 1 3324.615 3.38 C21(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VQLLDYVISSFYPEIQAAHTCDTDNIQR Q9DBC0 Selenoprotein O 1 3332.668 3.29 C21(Carbamidomethyl) Guanidinoacetate N- N-Term(Dimethyl); VQQAPIEEHWIIECNDGVFQR O35969 4 2596.257 3.34 methyltransferase C14(Carbamidomethyl) Guanidinoacetate N- N-Term(Dimethyl:2H(6)13C(2)); VQQAPIEEHWIIECNDGVFQR O35969 1 2604.318 2.60 methyltransferase C14(Carbamidomethyl) Cytochrome P450 N-Term(Dimethyl); VQQEIDEVIGQVQCPEMADQAR Q9JKY7 4 2571.219 6.52 CYP2D22 C14(Carbamidomethyl) Cytochrome P450 N-Term(Dimethyl); VQQEIDEVIGQVQCPEMADQAR Q9JKY7 2 2587.244 3.77 CYP2D22 C14(Carbamidomethyl); M17(Oxidation) Cytochrome P450 N-Term(Dimethyl:2H(6)13C(2)); VQQEIDEVIGQVQCPEMADQAR Q9JKY7 2 2579.258 4.36 CYP2D22 C14(Carbamidomethyl) VQQIYSDSDLKVEVCGTSWTYNPAAV E3 ubiquitin-protein N-Term(Dimethyl); K11(Dimethyl); F6ZBL2 1 4597.344 3.16 SKVAPAGSAISNASGER ligase MIB1 (Fragment) C15(Carbamidomethyl); K28(Dimethyl) VQSQYFRGQQHASVGAAFYVTGVTN B1AXE9 Angiomotin (Fragment) K27(HeavyDimethyl) 1 3007.529 2.98 QK Isoform 2 of Vesicular N-Term(Dimethyl:2H(6)13C(2)); VRDSYVAIANACCAPR O35633-2 inhibitory amino acid C12(Carbamidomethyl); 1 1858.945 2.27 transporter C13(Carbamidomethyl) Insulinoma-associated N-Term(Dimethyl); VRGGEDSDRALLLSPGCGGAR Q63ZV0 2 2171.074 2.57 protein 1 C17(Carbamidomethyl) Transitional N-Term(Dimethyl); VRLGDVISIQPCPDVK Q01853 endoplasmic reticulum 1 1852.032 2.28 C12(Carbamidomethyl); K16(Dimethyl) ATPase Transitional N-Term(Dimethyl:2H(6)13C(2)); VRLGDVISIQPCPDVK Q01853 endoplasmic reticulum C12(Carbamidomethyl); 1 1868.126 2.09 ATPase K16(HeavyDimethyl) ATP-dependent RNA N-Term(Dimethyl); VRPCVVYGGADTVQQIR Q62095 2 1946.024 2.55 helicase DDX3Y C4(Carbamidomethyl) ATP-dependent RNA N-Term(Dimethyl:2H(6)13C(2)); VRPCVVYGGADTVQQIR Q62095 1 1954.073 2.45 helicase DDX3Y C4(Carbamidomethyl) ATP-dependent RNA N-Term(Dimethyl:2H(6)13C(2)); VRPCVVYGGAEIGQQIR Q62167 1 1938.072 2.34 helicase DDX3X C4(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); 1,5-anhydro-D-fructose VRPITNQIECHPYLNQK Q8CEB6 C10(Carbamidomethyl); 1 2182.234 2.84 reductase K17(HeavyDimethyl) Isoform 2 of N-Term(Dimethyl); VRPSDEVCK Q91WT9-2 Cystathionine beta- 1 1145.597 2.10 C8(Carbamidomethyl); K9(Dimethyl) synthase Protein Sptbn5 N-Term(Dimethyl:2H(6)13C(2)); VRTENLAAACDLR F6UCX4 1 1524.818 1.96 (Fragment) C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); VSACGPGPKAPFSACHNKPEQGSVFTG K9(HeavyDimethyl); Q3URL2 Protein Gm10742 1 4419.439 2.66 SPAILYYSTLHNK C15(Carbamidomethyl); K18(HeavyDimethyl); K40(HeavyDimethyl) Isoform 2 of Gamma- N-Term(Dimethyl); M22(Oxidation); VSDSASASSGSDQGPSSRQHTMVSFLK Q8BKN5-2 tubulin complex K27(Dimethyl); K31(Dimethyl); 1 4076.056 3.19 PVLKQIIMAGK component 5 M35(Oxidation); K38(Dimethyl) Membrane-spanning 4- VSERFMSVLLLAPFWGSIMFIFSGSLSI M19(Oxidation); K33(HeavyDimethyl); Q99N05 domains subfamily A 1 3975.188 3.12 AAGVKPTK K36(HeavyDimethyl) member 4D Methylcrotonoyl-CoA N-Term(Dimethyl); VSGVECMIVANDATVK Q3ULD5 carboxylase beta chain, 2 1748.889 3.68 C6(Carbamidomethyl); K16(Dimethyl) mitochondrial Methylcrotonoyl-CoA N-Term(Dimethyl:2H(6)13C(2)); VSGVECMIVANDATVK Q3ULD5 carboxylase beta chain, C6(Carbamidomethyl); 1 1764.972 2.36 mitochondrial K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Methylcrotonoyl-CoA C6(Carbamidomethyl); VSGVECMIVANDATVKGGTYYPVTVK Q3ULD5 carboxylase beta chain, K16(HeavyDimethyl); 1 3030.778 2.76 K mitochondrial K26(HeavyDimethyl); K27(HeavyDimethyl) Dynein heavy chain 2, N-Term(Dimethyl); K6(Dimethyl); VSLAAKSLCMWVR P0C6F1 6 1592.876 2.26 axonemal C9(Carbamidomethyl); M10(Oxidation) N-Term(Dimethyl); VSLCGGGYCISK O88451 Retinol dehydrogenase 7 C4(Carbamidomethyl); 3 1356.662 2.44 C9(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C4(Carbamidomethyl); VSLCGGGYCISK O88451 Retinol dehydrogenase 7 3 1372.750 2.25 C9(Carbamidomethyl); K12(HeavyDimethyl) Inhibitor of nuclear VSQDLIGTERKMEELTMQMFNMEDD N-Term(Dimethyl); K11(Dimethyl); E9QMH7 factor kappa-B kinase- 1 3478.630 3.05 MLR M17(Oxidation); M19(Oxidation) interacting protein Guanine nucleotide- N-Term(Dimethyl:2H(6)13C(2)); binding protein VSRELPGHTGYLSCCR D3Z1T4 C14(Carbamidomethyl); 2 1927.966 2.44 G(I)/G(S)/G(T) subunit C15(Carbamidomethyl) beta-2 (Fragment) VSSAKKTEEMLSNQMLSGIPEVDLGID Uncharacterized protein K5(Dimethyl); K6(Dimethyl); Q3TQI7 1 3174.636 3.14 AK C9orf78 homolog K29(Dimethyl) C5(Carbamidomethyl); Isoform 3 of Sperm- VSSHCELESSSELKSAQASSSEKEPCAP K14(HeavyDimethyl); Q922B9-3 specific antigen 2 1 3873.962 2.69 LTIPSIR K23(HeavyDimethyl); homolog C26(Carbamidomethyl) Ribose-phosphate N-Term(Dimethyl:2H(6)13C(2)); VTAVIPCFPYAR Q9CS42 1 1429.804 2.25 pyrophosphokinase 2 C7(Carbamidomethyl) N-Term(Dimethyl); VTCIDPNPNFEK H3BJI7 Protein Mettl7a2Higd1c 2 1489.734 2.30 C3(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VTCIDPNPNFEK H3BJI7 Protein Mettl7a2Higd1c C3(Carbamidomethyl); 5 1505.818 2.83 K12(HeavyDimethyl) Methyltransferase-like N-Term(Dimethyl); VTCVDPNPNFEK Q9DD20 3 1475.715 2.74 protein 7B C3(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Methyltransferase-like VTCVDPNPNFEK Q9DD20 C3(Carbamidomethyl); 5 1491.801 2.88 protein 7B K12(HeavyDimethyl) 60 kDa heat shock N-Term(Dimethyl); VTDALNATRAAVEEGIVLGGGCALLR P63038 1 2654.436 2.79 protein, mitochondrial C22(Carbamidomethyl) 60 kDa heat shock N-Term(Dimethyl:2H(6)13C(2)); VTDALNATRAAVEEGIVLGGGCALLR P63038 2 2662.474 3.07 protein, mitochondrial C22(Carbamidomethyl) N-Term(Dimethyl); K4(Dimethyl); Proteasome subunit beta VTDKLTPIHDHIFCCR Q60692 C14(Carbamidomethyl); 1 2068.046 2.54 type-6 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit beta K4(HeavyDimethyl); VTDKLTPIHDHIFCCR Q60692 2 2084.137 2.60 type-6 C14(Carbamidomethyl); C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VTEGTIREEQEECDEELEEEPGQGAK O70318 Band 4.1-like protein 2 C13(Carbamidomethyl); 1 3063.449 3.24 K26(HeavyDimethyl) Isoform 2 of VTGTQFPEAPLPVPCNPNDVSHGYVT N-Term(Dimethyl); P34914-2 Bifunctional epoxide 3 3502.806 4.43 VKPGIR C15(Carbamidomethyl); K28(Dimethyl) hydrolase 2 Isoform 2 of N-Term(Dimethyl:2H(6)13C(2)); VTGTQFPEAPLPVPCNPNDVSHGYVT P34914-2 Bifunctional epoxide C15(Carbamidomethyl); 4 3518.899 3.65 VKPGIR hydrolase 2 K28(HeavyDimethyl) Succinate dehydrogenase N-Term(Dimethyl); K11(Dimethyl); VTLEYRPVIDKTLNEADCATVPPAIR Q8K2B3 [ubiquinone] 1 2997.603 3.91 C18(Carbamidomethyl) flavoprotein subunit, mitochondrial Succinate dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); VTLEYRPVIDKTLNEADCATVPPAIR Q8K2B3 [ubiquinone] K11(HeavyDimethyl); 1 3013.692 3.25 flavoprotein subunit, C18(Carbamidomethyl) mitochondrial VTMGGQCIALAPDDSLLVPAGTSYVW 3-hydroxyanthranilate N-Term(Dimethyl); Q78JT3 4 3034.507 4.40 ER 3,4-dioxygenase C7(Carbamidomethyl) VTMGGQCIALAPDDSLLVPAGTSYVW 3-hydroxyanthranilate N-Term(Dimethyl:2H(6)13C(2)); Q78JT3 1 3042.570 4.93 ER 3,4-dioxygenase C7(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl); VTNRDIICQIAYAR D3YYV8 4 1720.915 2.67 L5 (Fragment) C8(Carbamidomethyl) 60S ribosomal protein N-Term(Dimethyl:2H(6)13C(2)); VTNRDIICQIAYAR D3YYV8 2 1728.965 2.77 L5 (Fragment) C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VTPHIMVQLGLQYLLDDLLCKLTLYSN Q8R284 Protein Vmn1r84 M6(Oxidation); C20(Carbamidomethyl); 1 3404.929 3.02 R K21(HeavyDimethyl)

VTQSAYAQIVQFGMNEKVGQISFDLPR K17(HeavyDimethyl); M31(Oxidation); Q8JZQ2 AFG3-like protein 2 1 4890.558 3.66 QGDMVLEKPYSEATAR K35(HeavyDimethyl)

Rap guanine nucleotide VTRVVLLWVNNHFNDFEGDPAMTR E9QNQ4 N-Term(Dimethyl:2H(6)13C(2)) 1 2866.490 2.93 exchange factor 2 N-Term(Dimethyl); K9(Dimethyl); VTVAGLAGKDPVQCSR A2A815 Protein DJ-1 (Fragment) 6 1713.923 3.29 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VTVAGLAGKDPVQCSR A2A815 Protein DJ-1 (Fragment) K9(HeavyDimethyl); 7 1730.017 3.91 C14(Carbamidomethyl) Electron transfer flavoprotein-ubiquinone N-Term(Dimethyl); VTVFAEGCHGHLAK Q6PF96 9 1581.814 4.01 oxidoreductase, C8(Carbamidomethyl); K14(Dimethyl) mitochondrial

Electron transfer N-Term(Dimethyl:2H(6)13C(2)); flavoprotein-ubiquinone VTVFAEGCHGHLAK Q6PF96 C8(Carbamidomethyl); 9 1597.906 3.88 oxidoreductase, K14(HeavyDimethyl) mitochondrial

VTVNTNMTDLNDYLQHILK Q9JIF7 Coatomer subunit beta K19(Dimethyl) 1 2260.194 2.32 NADH-ubiquinone N-Term(Dimethyl); VVAACAMPVMK Q91VD9 oxidoreductase 75 kDa 1 1232.654 2.30 C5(Carbamidomethyl); K11(Dimethyl) subunit, mitochondrial Carbamoyl-phosphate N-Term(Dimethyl); VVAVDCGIK Q8C196 synthase [ammonia], 3 1016.578 2.26 C6(Carbamidomethyl); K9(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); VVAVDCGIK Q8C196 synthase [ammonia], C6(Carbamidomethyl); 7 1032.665 2.85 mitochondrial K9(HeavyDimethyl) Carbamoyl-phosphate N-Term(Dimethyl); VVAVDCGIKNNVIR Q8C196 synthase [ammonia], 23 1612.915 4.61 C6(Carbamidomethyl); K9(Dimethyl) mitochondrial Carbamoyl-phosphate N-Term(Dimethyl:2H(6)13C(2)); VVAVDCGIKNNVIR Q8C196 synthase [ammonia], C6(Carbamidomethyl); 28 1628.997 4.98 mitochondrial K9(HeavyDimethyl) K8(HeavyDimethyl); VVDYTTAKEFADSLGIPFLETSAKNAT Ras-related protein Rab- Q5SW87 K24(HeavyDimethyl); M34(Oxidation); 1 4608.420 3.05 NVEQSFMTMAAEIK 1A M36(Oxidation); K41(HeavyDimethyl)

N-Term(Dimethyl); VVEHVEQVLAIELLAACQGIEFLRPLK P35492 Histidine ammonia-lyase 1 3130.793 4.06 C17(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VVEHVEQVLAIELLAACQGIEFLRPLK P35492 Histidine ammonia-lyase C17(Carbamidomethyl); 1 3146.876 3.19 K27(HeavyDimethyl) VVFKEDTNTITDLGILYGGIGATVISAD N-Term(Dimethyl); K4(Dimethyl); G3X982 Aldehyde oxidase 3 1 3497.867 4.18 KSCR K29(Dimethyl); C31(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VVFKEDTNTITDLGILYGGIGATVISAD K4(HeavyDimethyl); G3X982 Aldehyde oxidase 3 1 3521.968 3.71 KSCR K29(HeavyDimethyl); C31(Carbamidomethyl) 3-ketoacyl-CoA thiolase, N-Term(Dimethyl); VVGYFVSGCDPTIMGIGPVPAINGALK Q8BWT1 11 2788.480 5.36 mitochondrial C9(Carbamidomethyl); K27(Dimethyl) N-Term(Dimethyl); 3-ketoacyl-CoA thiolase, VVGYFVSGCDPTIMGIGPVPAINGALK Q8BWT1 C9(Carbamidomethyl); M14(Oxidation); 3 2804.493 4.56 mitochondrial K27(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, VVGYFVSGCDPTIMGIGPVPAINGALK Q8BWT1 C9(Carbamidomethyl); 12 2804.582 6.39 mitochondrial K27(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-ketoacyl-CoA thiolase, VVGYFVSGCDPTIMGIGPVPAINGALK Q8BWT1 C9(Carbamidomethyl); M14(Oxidation); 1 2820.573 2.77 mitochondrial K27(HeavyDimethyl) N-Term(Dimethyl); VVGYFVSGCDPTIMGIGPVPAINGALK 3-ketoacyl-CoA thiolase, Q8BWT1 C9(Carbamidomethyl); K27(Dimethyl); 19 2944.608 5.94 K mitochondrial K28(Dimethyl) N-Term(Dimethyl); VVGYFVSGCDPTIMGIGPVPAINGALK 3-ketoacyl-CoA thiolase, Q8BWT1 C9(Carbamidomethyl); M14(Oxidation); 4 2960.596 4.83 K mitochondrial K27(Dimethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); VVGYFVSGCDPTIMGIGPVPAINGALK 3-ketoacyl-CoA thiolase, C9(Carbamidomethyl); Q8BWT1 4 2968.719 4.97 K mitochondrial K27(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); VVGYFVSGCDPTIMGIGPVPAINGALK 3-ketoacyl-CoA thiolase, C9(Carbamidomethyl); M14(Oxidation); Q8BWT1 3 2984.730 4.26 K mitochondrial K27(HeavyDimethyl); K28(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Eukaryotic initiation VVMALGDYMGASCHACIGGTNVR P60843 C13(Carbamidomethyl); 1 2475.180 3.87 factor 4A-I C16(Carbamidomethyl) Isoform 2 of 2- oxoglutarate N-Term(Dimethyl); VVNAPIFHVNSDDPEAVMYVCK Q60597-2 1 2560.257 3.12 dehydrogenase, C21(Carbamidomethyl); K22(Dimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); VVPPDSFQAQAMVDIVKALGWNYVST Metabotropic glutamate Q68ED2 M12(Oxidation); K17(HeavyDimethyl); 1 3981.168 2.90 LASEGSYGEK receptor 7 K36(HeavyDimethyl)

Fatty acid-binding N-Term(Dimethyl); VVRNEFTLGEECELETMTGEK P12710 1 2527.207 3.02 protein, liver C12(Carbamidomethyl); K21(Dimethyl) N-Term(Dimethyl); Fatty acid-binding VVRNEFTLGEECELETMTGEKVK P12710 C12(Carbamidomethyl); K21(Dimethyl); 12 2782.399 5.35 protein, liver K23(Dimethyl) N-Term(Dimethyl); Fatty acid-binding C12(Carbamidomethyl); VVRNEFTLGEECELETMTGEKVK P12710 2 2798.389 3.13 protein, liver M17(Oxidation); K21(Dimethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty acid-binding C12(Carbamidomethyl); VVRNEFTLGEECELETMTGEKVK P12710 2 2806.529 3.72 protein, liver K21(HeavyDimethyl); K23(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Fatty acid-binding C12(Carbamidomethyl); VVRNEFTLGEECELETMTGEKVK P12710 2 2822.519 3.77 protein, liver M17(Oxidation); K21(HeavyDimethyl); K23(HeavyDimethyl) Protein-glutamine N-Term(Dimethyl); VVSAMVNCNDDQGVLLGR P21981 gamma- 1 1974.980 3.14 C8(Carbamidomethyl) glutamyltransferase 2 Protein-glutamine N-Term(Dimethyl:2H(6)13C(2)); VVSAMVNCNDDQGVLLGR P21981 gamma- 1 1983.011 3.65 C8(Carbamidomethyl) glutamyltransferase 2 Bifunctional purine N-Term(Dimethyl); VVVCNLYPFVK Q9CWJ9 biosynthesis protein 1 1393.788 2.21 C4(Carbamidomethyl); K11(Dimethyl) PURH Multifunctional protein N-Term(Dimethyl); VVVLMGSTSDLGHCEK Q9DCL9 1 1787.903 2.50 ADE2 C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl); VVVVGCRGPIEINPR P47199 Quinone oxidoreductase 5 1692.952 2.78 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VVVVGCRGPIEINPR P47199 Quinone oxidoreductase 3 1700.997 2.65 C6(Carbamidomethyl) N-Term(Dimethyl); Ethanolamine-phosphate VWCDGCYDMVHYGHSNQLR A2ABY3 C3(Carbamidomethyl); 2 2425.023 3.29 cytidylyltransferase C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Ethanolamine-phosphate VWCDGCYDMVHYGHSNQLR A2ABY3 C3(Carbamidomethyl); 1 2433.068 3.57 cytidylyltransferase C6(Carbamidomethyl) Tumor protein p53- VWQFLSAMLFSSVAIMALALPDQL A2AGS6 inducible protein 11 M8(Oxidation); M16(Oxidation) 1 2683.405 2.27 (Fragment) N-Term(Dimethyl); VWSQACLDVCAPHLEEK Q3TNA1 Xylulose kinase C6(Carbamidomethyl); 4 2098.016 3.66 C10(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C6(Carbamidomethyl); VWSQACLDVCAPHLEEK Q3TNA1 Xylulose kinase 2 2114.086 3.22 C10(Carbamidomethyl); K17(HeavyDimethyl) VWVSPSNEQVLSQGSNGSVSVRNGDL Amphoterin-induced Q80ZD8 N-Term(Dimethyl); K29(Dimethyl) 1 3193.595 2.89 FFK protein 1 Isoform 2 of Serine N-Term(Dimethyl); VYAAEPSNADDCYQSK Q9QZX7-2 2 1873.814 3.27 racemase C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of Serine VYAAEPSNADDCYQSK Q9QZX7-2 C12(Carbamidomethyl); 1 1889.917 2.14 racemase K16(HeavyDimethyl) Hydroxyacylglutathione N-Term(Dimethyl); VYCGHEYTVNNLK E9Q2H8 hydrolase, mitochondrial 1 1652.804 3.44 C3(Carbamidomethyl); K13(Dimethyl) (Fragment)

Hydroxyacylglutathione N-Term(Dimethyl:2H(6)13C(2)); VYCGHEYTVNNLK E9Q2H8 hydrolase, mitochondrial C3(Carbamidomethyl); 2 1668.891 2.94 (Fragment) K13(HeavyDimethyl) Cytochrome b-c1 N-Term(Dimethyl); VYEEDAVPGLTPCR Q9CZ13 complex subunit 1, 12 1633.783 3.80 C13(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); VYEEDAVPGLTPCR Q9CZ13 complex subunit 1, 7 1641.825 3.31 C13(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl); VYEEDAVPGLTPCRFTGSEIR Q9CZ13 complex subunit 1, 2 2424.185 2.99 C13(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); VYEEDAVPGLTPCRFTGSEIR Q9CZ13 complex subunit 1, 2 2432.238 3.15 C13(Carbamidomethyl) mitochondrial Glutamate N-Term(Dimethyl); VYEGSILEADCDILIPAASEK P26443 dehydrogenase 1, 16 2349.189 6.18 C11(Carbamidomethyl); K21(Dimethyl) mitochondrial Glutamate N-Term(Dimethyl:2H(6)13C(2)); VYEGSILEADCDILIPAASEK P26443 dehydrogenase 1, C11(Carbamidomethyl); 8 2365.279 5.52 mitochondrial K21(HeavyDimethyl) Glutamate N-Term(Dimethyl); VYEGSILEADCDILIPAASEKQLTK P26443 dehydrogenase 1, C11(Carbamidomethyl); K21(Dimethyl); 4 2847.503 6.81 mitochondrial K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate C11(Carbamidomethyl); VYEGSILEADCDILIPAASEKQLTK P26443 dehydrogenase 1, 11 2871.637 6.68 K21(HeavyDimethyl); mitochondrial K25(HeavyDimethyl) Glutamate N-Term(Dimethyl); VYEGSILEADCDILIPAASEKQLTKSNA P26443 dehydrogenase 1, C11(Carbamidomethyl); K21(Dimethyl); 8 3372.766 5.53 PR mitochondrial K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate VYEGSILEADCDILIPAASEKQLTKSNA C11(Carbamidomethyl); P26443 dehydrogenase 1, 4 3396.911 5.46 PR K21(HeavyDimethyl); mitochondrial K25(HeavyDimethyl) Cytochrome c oxidase N-Term(Dimethyl); K3(Dimethyl); VYKSLCPVSWVSAWDDR P56391 1 2124.065 2.79 subunit 6B1 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Cytochrome c oxidase VYKSLCPVSWVSAWDDR P56391 K3(HeavyDimethyl); 1 2140.152 2.85 subunit 6B1 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); VYNVDAALMAKLKLCVADGPSNNAT Vang-like protein 1 K11(HeavyDimethyl); F7BWJ0 1 3171.771 2.54 GQSR (Fragment) K13(HeavyDimethyl); C15(Carbamidomethyl) Isoform Short of N-Term(Dimethyl); VYSYYNLEESCTR P01027-2 6 1711.760 3.23 Complement C3 C11(Carbamidomethyl) Isoform Short of N-Term(Dimethyl:2H(6)13C(2)); VYSYYNLEESCTR P01027-2 3 1719.800 3.73 Complement C3 C11(Carbamidomethyl) N-Term(Dimethyl); K5(Dimethyl); Thioredoxin domain- VYVAKVDCTADSDVCSAQGVR E9PXX7 C8(Carbamidomethyl); 3 2356.126 3.99 containing protein 5 C15(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Thioredoxin domain- K5(HeavyDimethyl); VYVAKVDCTADSDVCSAQGVR E9PXX7 3 2372.215 2.99 containing protein 5 C8(Carbamidomethyl); C15(Carbamidomethyl) WASVFYTIIIPMLNPLIYSLRNKDVK Q8VGS3 Olfactory receptor 1019 K23(Dimethyl); K26(Dimethyl) 1 3150.823 2.56 N-Term(Dimethyl); WCAVSEHENTK Q921I1 Serotransferrin 2 1416.656 2.23 C2(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); WCAVSEHENTK Q921I1 Serotransferrin C2(Carbamidomethyl); 2 1432.743 2.36 K11(HeavyDimethyl) G1/S-specific cyclin-D3 WDLAAVIAHDFLALILHRLSLPSDR S4R2N1 N-Term(Dimethyl:2H(6)13C(2)) 2 2878.649 3.13 (Fragment) F-box-like/WD repeat- C11(Carbamidomethyl); WDPSGMLLASCSDDMTLKIWSMK Q9QXE7 containing protein K18(HeavyDimethyl); 1 2744.338 2.80 TBL1X K23(HeavyDimethyl) NADH dehydrogenase WENPLMGWASTADPLSNMVLTFSAK E9QPX3 [ubiquinone] iron-sulfur K25(HeavyDimethyl) 1 2802.363 2.27 protein 4, mitochondrial

Phenazine biosynthesis- N-Term(Dimethyl); WFTPEAEFPLCGHATLASAAVLFQK Q9CXN7 like domain-containing 1 2847.461 2.86 C11(Carbamidomethyl); K25(Dimethyl) protein 2

Phenazine biosynthesis- N-Term(Dimethyl:2H(6)13C(2)); WFTPEAEFPLCGHATLASAAVLFQK Q9CXN7 like domain-containing C11(Carbamidomethyl); 2 2863.545 3.33 protein 2 K25(HeavyDimethyl)

Phenazine biosynthesis- N-Term(Dimethyl); WFTPVSEVPLCGHATLASAAVLFHK Q9DCG6 like domain-containing 1 2794.480 2.66 C11(Carbamidomethyl); K25(Dimethyl) protein 1

Phenazine biosynthesis- N-Term(Dimethyl:2H(6)13C(2)); WFTPVSEVPLCGHATLASAAVLFHK Q9DCG6 like domain-containing C11(Carbamidomethyl); 2 2810.573 3.28 protein 1 K25(HeavyDimethyl) WGFVLPESSPAKPDYINLASSMSPILFS Transmembrane protein Q3KQJ0 K12(HeavyDimethyl); M22(Oxidation) 1 4179.175 3.02 WAAILFSER 69 Isoform 3 of N-Term(Dimethyl); WGLGGTCVNVGCIPK Q9JLT4-3 Thioredoxin reductase 2, C7(Carbamidomethyl); 1 1673.850 2.59 mitochondrial C12(Carbamidomethyl); K15(Dimethyl) Alpha-aminoadipic WLGPKGSDCGIVNVNIPTSGAEIGGAF N-Term(Dimethyl); K5(Dimethyl); G3UYR8 semialdehyde 1 3171.572 3.65 GGEK C9(Carbamidomethyl); K31(Dimethyl) dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); Alpha-aminoadipic WLGPKGSDCGIVNVNIPTSGAEIGGAF K5(HeavyDimethyl); G3UYR8 semialdehyde 2 3195.766 4.45 GGEK C9(Carbamidomethyl); dehydrogenase K31(HeavyDimethyl)

NADH dehydrogenase N-Term(Dimethyl); WLHCMTDDPPTTNPPTAR Q7TMF3 [ubiquinone] 1 alpha 4 2137.968 3.45 C4(Carbamidomethyl) subcomplex subunit 12 NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); WLHCMTDDPPTTNPPTAR Q7TMF3 [ubiquinone] 1 alpha 2 2146.018 3.54 C4(Carbamidomethyl) subcomplex subunit 12

Indolethylamine N- N-Term(Dimethyl); K3(Dimethyl); WLKKEPGAYDWSSIVQHACELEGDR P40936 3 3058.524 3.51 methyltransferase K4(Dimethyl); C19(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Indolethylamine N- K3(HeavyDimethyl); WLKKEPGAYDWSSIVQHACELEGDR P40936 1 3082.647 2.98 methyltransferase K4(HeavyDimethyl); C19(Carbamidomethyl) N-Term(Dimethyl); WLLLCNPGLADLIAEK Q3UEJ6 Phosphorylase 1 1882.050 2.56 C5(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); WLLLCNPGLADLIAEK Q3UEJ6 Phosphorylase C5(Carbamidomethyl); 4 1898.151 3.36 K16(HeavyDimethyl) Adenosylhomocysteinas N-Term(Dimethyl); K9(Dimethyl); WLNENAVEKVNIKPQVDRYWLK P50247 1 2854.634 2.24 e K13(Dimethyl); K22(Dimethyl) Succinate-semialdehyde N-Term(Dimethyl:2H(6)13C(2)); WLPAPATFPVYDPASGAKLGTVADCG Q8BWF0 dehydrogenase, K18(HeavyDimethyl); 1 3285.754 2.90 VPEAR mitochondrial C25(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock 70 kDa WNSPAEEGLSDCEVFPK Q61316 C12(Carbamidomethyl); 1 2037.023 2.53 protein 4 K17(HeavyDimethyl) Probable 2-oxoglutarate dehydrogenase E1 N-Term(Dimethyl); WQGLVQPEACVTTWDTGVPLELLR A2ATU0 3 2796.449 3.29 component DHKTD1, C10(Carbamidomethyl) mitochondrial

Probable 2-oxoglutarate dehydrogenase E1 N-Term(Dimethyl:2H(6)13C(2)); WQGLVQPEACVTTWDTGVPLELLR A2ATU0 1 2804.498 2.36 component DHKTD1, C10(Carbamidomethyl) mitochondrial

WQGVHEGSPEARAVAVGTEESGAEGL NK1 transcription factor- P42580 N-Term(Dimethyl:2H(6)13C(2)) 1 3902.906 3.28 PASPGSPGSPRPR related protein 2 Serine/threonine-protein WSGAQPLEQPSGSVLWMAAEVIR P04627 N-Term(Dimethyl:2H(6)13C(2)) 1 2548.308 2.41 kinase A-Raf WSGMPPTCEAPVSPTRPLVVALSAAG N-Term(Dimethyl); Q00690 E-selectin 1 4824.466 3.45 TSLLTSSSLLYLLMRYFR C8(Carbamidomethyl) Adenosylhomocysteinas N-Term(Dimethyl); WSSCNIFSTQDHAAAAIAK P50247 12 2134.038 4.84 e C4(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Adenosylhomocysteinas WSSCNIFSTQDHAAAAIAK P50247 C4(Carbamidomethyl); 5 2150.125 4.71 e K19(HeavyDimethyl) T-complex protein 1 N-Term(Dimethyl); WSSLACNIALDAVK E9Q133 2 1603.849 2.41 subunit gamma C6(Carbamidomethyl); K14(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); WTAHYPPGPMPWPVLGNLLHMDFQN Cytochrome P450 Q9JKY7 M10(Oxidation); M21(Oxidation); 1 3781.860 2.61 MPAGFQK CYP2D22 K32(HeavyDimethyl) C9(Carbamidomethyl); M10(Oxidation); WTISNFSFCMDGIMETITSPKFSLK K7N6S3 Protein Gm4778 1 3012.490 2.89 K21(Dimethyl); K25(Dimethyl)

N-Term(Dimethyl:2H(6)13C(2)); WTQDTDMRVVLRINSAHYYAVVVSQ D3YY48 Beta-glucuronidase M7(Oxidation); C29(Carbamidomethyl); 1 3902.090 2.97 GLLCPGHK K33(HeavyDimethyl) N-Term(Dimethyl); Asialoglycoprotein WVCETKLDKAN B1AR34 C3(Carbamidomethyl); K6(Dimethyl); 1 1447.763 2.05 receptor 1 K9(Dimethyl) N-Term(Dimethyl); WVCTSGDPQDLAVTDHLATSVLEK Q8VC12 Urocanate hydratase 2 2698.344 3.04 C3(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); WVCTSGDPQDLAVTDHLATSVLEK Q8VC12 Urocanate hydratase C3(Carbamidomethyl); 3 2714.424 3.72 K24(HeavyDimethyl) Aldo-keto reductase N-Term(Dimethyl); WVDPSSPVLLNDPILCDMAK G3X9Y6 1 2326.186 3.16 family 1, member C19 C16(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Aldo-keto reductase WVDPSSPVLLNDPILCDMAK G3X9Y6 C16(Carbamidomethyl); 1 2342.282 3.62 family 1, member C19 K20(HeavyDimethyl) Proline dehydrogenase XFTPETLGVSGTVDLLDWNSLIDSR F6PYI8 1, mitochondrial X1(L) 2 2748.414 2.38 (Fragment) Mothers against N-Term(Dimethyl); X1(L); XWQGCSWGRRSLDGR F7BUP2 decapentaplegic 4 1861.945 2.35 C5(Carbamidomethyl) homolog 3 (Fragment) N-Term(Dimethyl:2H(6)13C(2)); YACFQVENDQER G3X972 Protein Sec24c 1 1594.732 2.21 C3(Carbamidomethyl) Phosphoglycerate N-Term(Dimethyl); YADLTEDQLPSCESLKDTIAR Q9DBJ1 9 2481.209 5.18 mutase 1 C12(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Phosphoglycerate YADLTEDQLPSCESLKDTIAR Q9DBJ1 C12(Carbamidomethyl); 8 2497.309 4.56 mutase 1 K16(HeavyDimethyl) Isoform 2 of 2- YAELLVSQGVVNQPEYEEEISKYDKIC oxoglutarate N-Term(Dimethyl); K22(Dimethyl); Q60597-2 1 4021.012 3.36 EEAFTR dehydrogenase, K25(Dimethyl); C27(Carbamidomethyl) mitochondrial N-Term(Dimethyl); YAFRVFSAESEVEMECTLRNSQMLDE Isoform 3 of Aprataxin C16(Carbamidomethyl); Q9D842-3 1 4288.957 3.13 DDILSEMQK and PNK-like factor M23(Oxidation); M33(Oxidation); K35(Dimethyl) Adenylosuccinate YAHMVNGFTALALTKLDILDVLSEIK P28650 K15(Dimethyl); K26(Dimethyl) 1 2931.591 2.99 synthetase isozyme 1 60S ribosomal protein N-Term(Dimethyl); YAICSALAASALPALVMSK Q9D8E6 4 1993.094 3.98 L4 C4(Carbamidomethyl); K19(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 60S ribosomal protein YAICSALAASALPALVMSK Q9D8E6 C4(Carbamidomethyl); 6 2009.188 3.67 L4 K19(HeavyDimethyl) YARTDEIGVAFGITIDFDTVNK Q9CZD3 Glycine--tRNA ligase K22(Dimethyl) 1 2473.233 2.37 N-Term(Dimethyl); YASICQQNGLVPIVEPEVLPDGDHDLE Fructose-bisphosphate Q91Y97 C5(Carbamidomethyl); 5 4094.941 5.25 HCQYVSEK aldolase B C29(Carbamidomethyl); K35(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YASICQQNGLVPIVEPEVLPDGDHDLE Fructose-bisphosphate C5(Carbamidomethyl); Q91Y97 2 4111.047 4.64 HCQYVSEK aldolase B C29(Carbamidomethyl); K35(HeavyDimethyl) N-Term(Dimethyl); YASICQQNGLVPIVEPEVLPDGDHDLE Fructose-bisphosphate C5(Carbamidomethyl); Q91Y97 7 4867.471 5.80 HCQYVSEKVLAAVYK aldolase B C29(Carbamidomethyl); K35(Dimethyl); K42(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); C5(Carbamidomethyl); YASICQQNGLVPIVEPEVLPDGDHDLE Fructose-bisphosphate Q91Y97 C29(Carbamidomethyl); 3 4891.561 6.54 HCQYVSEKVLAAVYK aldolase B K35(HeavyDimethyl); K42(HeavyDimethyl) N-Term(Dimethyl); YCAGWADKIHGQTIPSDGDIFTYTR P24549 Retinal dehydrogenase 1 6 2928.400 3.63 C2(Carbamidomethyl); K8(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YCAGWADKIHGQTIPSDGDIFTYTR P24549 Retinal dehydrogenase 1 C2(Carbamidomethyl); 9 2944.488 4.72 K8(HeavyDimethyl) N-Term(Dimethyl); Phenylalanine-4- YCGFREDNIPQLEDVSQFLQTCTGFR P16331 C2(Carbamidomethyl); 1 3208.488 3.14 hydroxylase C22(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Phenylalanine-4- YCGFREDNIPQLEDVSQFLQTCTGFR P16331 C2(Carbamidomethyl); 2 3216.536 3.90 hydroxylase C22(Carbamidomethyl) N-Term(Dimethyl); Interferon gamma YCISVDGISSFWQVRTEKSK P15261 C2(Carbamidomethyl); K18(Dimethyl); 1 2474.272 2.57 receptor 1 K20(Dimethyl) N-Term(Dimethyl); YCNTWPMAISMLASK Q64442 Sorbitol dehydrogenase 5 1828.876 3.44 C2(Carbamidomethyl); K15(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YCNTWPMAISMLASK Q64442 Sorbitol dehydrogenase C2(Carbamidomethyl); 2 1844.981 2.73 K15(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); C-type lectin domain C2(Carbamidomethyl); YCTDNQCVSLQPQGLGPK P70194 2 2137.123 2.77 family 4 member F C7(Carbamidomethyl); K18(HeavyDimethyl) NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); YCTFNDDIQGTASVAVAGLLAALR P06801 1 2562.343 3.49 enzyme C2(Carbamidomethyl) Delta(3,5)-Delta(2,4)- N-Term(Dimethyl:2H(6)13C(2)); YCTQDAFFQIKEVDMGLAADVGTLQR dienoyl-CoA isomerase, C2(Carbamidomethyl); F7B227 1 3422.881 3.03 LPK mitochondrial K11(HeavyDimethyl); (Fragment) K29(HeavyDimethyl) N-Term(Dimethyl); Maleylacetoacetate YCVGDEVSMADVCLVPQVANAER Q9WVL0 C2(Carbamidomethyl); 6 2610.203 4.85 isomerase C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Maleylacetoacetate YCVGDEVSMADVCLVPQVANAER Q9WVL0 C2(Carbamidomethyl); 2 2618.242 4.58 isomerase C13(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K7(HeavyDimethyl); YDGSEYKLSHGSVVIAAVISCTNNCNP Iron-responsive element- C21(Carbamidomethyl); Q811J3 1 4282.362 3.55 SVMLAAGLLAKK binding protein 2 C25(Carbamidomethyl); K38(HeavyDimethyl); K39(HeavyDimethyl) Sulfide:quinone N-Term(Dimethyl); YDGYTSCPLVTGYNR Q9R112 oxidoreductase, 1 1793.809 2.75 C7(Carbamidomethyl) mitochondrial Sulfide:quinone N-Term(Dimethyl:2H(6)13C(2)); YDGYTSCPLVTGYNR Q9R112 oxidoreductase, 2 1801.856 2.67 C7(Carbamidomethyl) mitochondrial Eukaryotic translation N-Term(Dimethyl); YEDICPSTHNMDVPNIK Q8BGY2 2 2088.973 2.77 initiation factor 5A-2 C5(Carbamidomethyl); K17(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Eukaryotic translation YEDICPSTHNMDVPNIK P63242 C5(Carbamidomethyl); 1 2105.090 2.94 initiation factor 5A-1 K17(HeavyDimethyl) YEDICPSTHNMDVPNIKRNDFQLIGIQD Eukaryotic translation P63242 C5(Carbamidomethyl); K17(Dimethyl) 1 4778.278 3.42 GYLSLLQDSGEVR initiation factor 5A-1 Vacuolar protein sorting- N-Term(Dimethyl:2H(6)13C(2)); YEEALMAAEISQR Q5KU39 associated protein 41 1 1562.788 1.98 M6(Oxidation) homolog YEPSPGDLDGFPEVFEGGGSRKR Q6NS86 Protein Zfp366 N-Term(Dimethyl); K22(Dimethyl) 2 2552.249 2.85 Trifunctional enzyme N-Term(Dimethyl); YESAYGTQFTPCQLLLDHANNSSK Q8BMS1 subunit alpha, 1 2800.313 2.79 C12(Carbamidomethyl); K24(Dimethyl) mitochondrial Ankyrin repeat and IBR YEVIQHVEEQSK Q6ZPS6 domain-containing K12(HeavyDimethyl) 2 1524.819 2.20 protein 1 YEVQIPENSPVGSQVATVSARDLDIGD Q91Y00 Protein Pcdhb2 2 4619.267 4.08 HGNIAYAFSQASEDIR Coiled-coil-helix-coiled- coil-helix domain- N-Term(Dimethyl); YEYHPVCADLQTK F6QFL0 containing protein 3, 1 1679.803 2.34 C7(Carbamidomethyl); K13(Dimethyl) mitochondrial (Fragment) YFAGNLASGGAAGATSLCFVYPLDFA N-Term(Dimethyl); P51881 ADP/ATP translocase 2 19 2824.394 6.59 R C18(Carbamidomethyl) YFAGNLASGGAAGATSLCFVYPLDFA N-Term(Dimethyl:2H(6)13C(2)); P51881 ADP/ATP translocase 2 15 2832.425 6.94 R C18(Carbamidomethyl) YFAGTMAEETAPAVLER Q64374 Regucalcin M6(Oxidation) 2 1871.880 3.30 Cytosolic 10- N-Term(Dimethyl); YFAGWCDKIQGATIPINQARPNR Q8R0Y6 formyltetrahydrofolate 7 2732.396 4.49 C6(Carbamidomethyl); K8(Dimethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); YFAGWCDKIQGATIPINQARPNR Q8R0Y6 formyltetrahydrofolate C6(Carbamidomethyl); 2 2748.504 3.01 dehydrogenase K8(HeavyDimethyl) YFATGSADALVSLWDVDELVCVR Q8VE80 THO complex subunit 3 C21(Carbamidomethyl) 2 2586.245 2.76 N-Term(Dimethyl:2H(6)13C(2)); Ras GTPase-activating- YFQEACDVPEPEEK Q3UQ44 C6(Carbamidomethyl); 1 1812.883 2.56 like protein IQGAP2 K14(HeavyDimethyl) Cytochrome b-c1 N-Term(Dimethyl); YFYDQCPAVAGYGPIEQLPDYNRIR Q9CZ13 complex subunit 1, 2 3033.461 3.69 C6(Carbamidomethyl) mitochondrial Cytochrome b-c1 N-Term(Dimethyl:2H(6)13C(2)); YFYDQCPAVAGYGPIEQLPDYNRIR Q9CZ13 complex subunit 1, 1 3041.502 3.02 C6(Carbamidomethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); YGESYLDQILNGMDEELGSLEELEKK F7D1P5 Ankyrin-1 (Fragment) M13(Oxidation); K25(HeavyDimethyl); 1 3126.596 2.61 K26(HeavyDimethyl) A disintegrin and C5(Carbamidomethyl); metalloproteinase with YGEVCSELWCLSKSNR P58459 C10(Carbamidomethyl); 1 2023.971 2.17 thrombospondin motifs K13(HeavyDimethyl) 10 N-Term(Dimethyl:2H(6)13C(2)); Aspartyl/asparaginyl K3(HeavyDimethyl); YGKAQCEDDLAEKQR Q8CBM2 1 1919.066 2.32 beta-hydroxylase C6(Carbamidomethyl); K13(HeavyDimethyl) NADP-dependent malic N-Term(Dimethyl); YGMNCLIQFEDFANR P06801 1 1905.866 2.23 enzyme C5(Carbamidomethyl) NADP-dependent malic N-Term(Dimethyl:2H(6)13C(2)); YGMNCLIQFEDFANR P06801 1 1913.919 2.58 enzyme C5(Carbamidomethyl) N-Term(Dimethyl); K12(Dimethyl); YGPMEEPQVIEKDLPCYL S4R1E5 Glutathione peroxidase 1 2237.103 2.49 C16(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YGPMEEPQVIEKDLPCYL S4R1E5 Glutathione peroxidase K12(HeavyDimethyl); 1 2253.180 2.28 C16(Carbamidomethyl) Phospholipid hydroperoxide N-Term(Dimethyl); YGPMEEPQVIERDLPCYL Q91XR9 1 2237.089 2.30 glutathione peroxidase, C16(Carbamidomethyl) nuclear N-Term(Dimethyl); Complement factor B YGQTLRPICLPCTEGTTR B8JJM3 C9(Carbamidomethyl); 2 2151.062 2.79 (Fragment) C12(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Complement factor B YGQTLRPICLPCTEGTTR B8JJM3 C9(Carbamidomethyl); 1 2159.104 3.18 (Fragment) C12(Carbamidomethyl) PC-esterase domain- YGRNSLSSYKQNLENLFGR Q8BGX1 N-Term(Dimethyl); K10(Dimethyl) 1 2302.163 2.43 containing protein 1B Proteasome subunit N-Term(Dimethyl); YGYEIPVDMLCKR E0CXB1 1 1699.861 2.46 alpha type-6 C11(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit YGYEIPVDMLCKR E0CXB1 C11(Carbamidomethyl); 1 1715.940 2.18 alpha type-6 K12(HeavyDimethyl) YGYLPPTDPRMSVLRSAETMQSALAA Matrix metalloproteinase-M20(Oxidation); M27(Oxidation); B1AVG8 1 4284.105 3.01 MQQFYGINMTGK 16 (Fragment) K38(Dimethyl) Ubiquitin carboxyl- YHHLENEHAWVRER B2RQC2 N-Term(Dimethyl) 1 1903.926 2.17 terminal hydrolase 42 Isoform 2 of NADH dehydrogenase N-Term(Dimethyl); YHIQVCTTTPCMLR Q9D6J6-2 [ubiquinone] C6(Carbamidomethyl); 2 1807.862 2.79 flavoprotein 2, C11(Carbamidomethyl) mitochondrial Isoform 2 of NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); YHIQVCTTTPCMLR Q9D6J6-2 [ubiquinone] C6(Carbamidomethyl); 1 1815.931 2.33 flavoprotein 2, C11(Carbamidomethyl) mitochondrial YHKQNIFMGEDQFNVPMEPEFVTFDT K3(HeavyDimethyl); M17(Oxidation); Q9Z0K8 Pantetheinase 1 3680.807 2.58 PFGK K30(HeavyDimethyl) RNA polymerase II YIAIVSYEQRQNYK Q3UKU1 N-Term(Dimethyl); K14(Dimethyl) 2 1830.986 2.36 elongation factor ELL2 N-Term(Dimethyl); YICPHAFDIVGLSPDSQEDESGIKQAAE Acyl-protein thioesterase D3Z269 C3(Carbamidomethyl); K24(Dimethyl); 1 3488.716 3.53 TVK 1 (Fragment) K31(Dimethyl) N-Term(Dimethyl); YICTTSAIQNR Q91V92 ATP-citrate synthase 4 1354.672 2.53 C3(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YICTTSAIQNR Q91V92 ATP-citrate synthase 2 1362.719 2.47 C3(Carbamidomethyl) Betaine--homocysteine S-C5(Carbamidomethyl); YIGGCCGFEPYHIR O35490 24 1728.757 3.27 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl); Betaine--homocysteine S- YIGGCCGFEPYHIR O35490 C5(Carbamidomethyl); 48 1756.789 5.57 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- YIGGCCGFEPYHIR O35490 C5(Carbamidomethyl); 57 1764.831 5.71 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl); Betaine--homocysteine S- YIGGCCGFEPYHIRAIAEELAPER O35490 C5(Carbamidomethyl); 10 2836.362 4.20 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Betaine--homocysteine S- YIGGCCGFEPYHIRAIAEELAPER O35490 C5(Carbamidomethyl); 2 2844.395 2.84 methyltransferase 1 C6(Carbamidomethyl) N-Term(Dimethyl); YIIWSPVCR P11352 Glutathione peroxidase 1 3 1221.644 2.48 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YIIWSPVCR P11352 Glutathione peroxidase 1 1 1229.688 2.01 C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YIIWSPVCRNDIAWNFEK P11352 Glutathione peroxidase 1 C8(Carbamidomethyl); 1 2383.280 2.56 K18(HeavyDimethyl) Homogentisate 1,2- N-Term(Dimethyl); YISGFGNECASEDPR O09173 5 1729.742 4.83 dioxygenase C9(Carbamidomethyl) Homogentisate 1,2- N-Term(Dimethyl:2H(6)13C(2)); YISGFGNECASEDPR O09173 10 1737.785 4.70 dioxygenase C9(Carbamidomethyl) N-Term(Dimethyl); Homogentisate 1,2- YISGFGNECASEDPRCPGSLPK O09173 C9(Carbamidomethyl); 12 2497.137 4.04 dioxygenase C16(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Homogentisate 1,2- C9(Carbamidomethyl); YISGFGNECASEDPRCPGSLPK O09173 4 2513.237 4.06 dioxygenase C16(Carbamidomethyl); K22(HeavyDimethyl) Phosphatidylinositol K2(HeavyDimethyl); YKEVCPWMQTAYTR P0C5E4 1 1884.920 2.22 phosphatase PTPRQ C5(Carbamidomethyl); M8(Oxidation) N-Term(Dimethyl); K2(Dimethyl); YKEWVDQNSPVLLNDPVLCDVAK Q9JLI0 Aldo-keto reductase a 1 2786.444 3.05 C19(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); YKEWVDQNSPVLLNDPVLCDVAK Q9JLI0 Aldo-keto reductase a 1 2810.577 2.80 C19(Carbamidomethyl); K23(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); Aldo-keto reductase YKEWVDQNSPVLLNDPVLCDVAKK Q8VC28 C19(Carbamidomethyl); K23(Dimethyl); 2 2942.553 4.01 family 1 member C13 K24(Dimethyl) N-Term(Dimethyl); K2(Dimethyl); YKEWVDQNSPVLLNDPVLCDVAKR Q9JLI0 Aldo-keto reductase a 1 2942.529 3.92 C19(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); YKEWVDQNSPVLLNDPVLCDVAKR Q9JLI0 Aldo-keto reductase a 2 2966.685 2.66 C19(Carbamidomethyl); K23(HeavyDimethyl) Protein disulfide- N-Term(Dimethyl); K2(Dimethyl); YKPESDELTAEKITEFCHR P09103 1 2437.199 3.11 isomerase K12(Dimethyl); C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Protein disulfide- K2(HeavyDimethyl); YKPESDELTAEKITEFCHR P09103 2 2461.341 3.34 isomerase K12(HeavyDimethyl); C17(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); Aldo-keto reductase YKPVCNQVECHLYLNQR G3X9Y6 C5(Carbamidomethyl); 7 2277.120 3.86 family 1, member C19 C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Aldo-keto reductase K2(HeavyDimethyl); YKPVCNQVECHLYLNQR G3X9Y6 6 2293.213 3.54 family 1, member C19 C5(Carbamidomethyl); C10(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); YKPVCNQVECHLYLNQSK Q9JLI0 Aldo-keto reductase a C5(Carbamidomethyl); 2 2364.185 2.79 C10(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); YKPVCNQVECHLYLNQSK Q9JLI0 Aldo-keto reductase a C5(Carbamidomethyl); 1 2388.308 2.92 C10(Carbamidomethyl); K18(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); 3-alpha-hydroxysteroid C5(Carbamidomethyl); YKPVCNQVECHLYLNQSQMLDYCK Q91WT7 1 3174.489 3.28 dehydrogenase type 1 C10(Carbamidomethyl); C23(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); C5(Carbamidomethyl); 3-alpha-hydroxysteroid YKPVCNQVECHLYLNQSQMLDYCK Q91WT7 C10(Carbamidomethyl); 1 3214.617 3.00 dehydrogenase type 1 M19(Oxidation); C23(Carbamidomethyl); K24(HeavyDimethyl) Estradiol 17 beta- N-Term(Dimethyl); K2(Dimethyl); YKPVCNQVECHPYLNQGK D3Z3P8 dehydrogenase 5 C5(Carbamidomethyl); 21 2318.141 4.92 (Fragment) C10(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Estradiol 17 beta- K2(HeavyDimethyl); YKPVCNQVECHPYLNQGK D3Z3P8 dehydrogenase 5 C5(Carbamidomethyl); 29 2342.267 5.57 (Fragment) C10(Carbamidomethyl); K18(HeavyDimethyl) N-Term(Dimethyl); K2(Dimethyl); Estradiol 17 beta- C5(Carbamidomethyl); YKPVCNQVECHPYLNQGKLLDFCR D3Z3P8 dehydrogenase 5 1 3122.538 2.78 C10(Carbamidomethyl); K18(Dimethyl); (Fragment) C23(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); K2(HeavyDimethyl); Estradiol 17 beta- C5(Carbamidomethyl); YKPVCNQVECHPYLNQGKLLDFCR D3Z3P8 dehydrogenase 5 8 3146.665 3.62 C10(Carbamidomethyl); (Fragment) K18(HeavyDimethyl); C23(Carbamidomethyl) N-Term(Dimethyl); K2(Dimethyl); MCG9092, isoform YKPVCNQVECHPYLNQR Q9CZU0 C5(Carbamidomethyl); 1 2261.074 2.66 CRA_b C10(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); MCG9092, isoform K2(HeavyDimethyl); YKPVCNQVECHPYLNQR Q9CZU0 1 2277.180 2.32 CRA_b C5(Carbamidomethyl); C10(Carbamidomethyl) 3-oxo-5-beta-steroid 4- N-Term(Dimethyl); K2(Dimethyl); YKPVTNQVECHPYFTQTK Q8VCX1 10 2324.168 3.59 dehydrogenase C10(Carbamidomethyl); K18(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 3-oxo-5-beta-steroid 4- K2(HeavyDimethyl); YKPVTNQVECHPYFTQTK Q8VCX1 5 2348.306 2.82 dehydrogenase C10(Carbamidomethyl); K18(HeavyDimethyl) Isocitrate dehydrogenase N-Term(Dimethyl); K2(Dimethyl); YKSQFEAQKICYEHR O88844 1 2071.044 2.23 [NADP] cytoplasmic K9(Dimethyl); C11(Carbamidomethyl) Phosphoenolpyruvate N-Term(Dimethyl); YLAAAFPSACGK Q9Z2V4 carboxykinase, cytosolic 1 1311.670 2.36 C10(Carbamidomethyl); K12(Dimethyl) [GTP] Phosphoenolpyruvate N-Term(Dimethyl:2H(6)13C(2)); YLAAAFPSACGK Q9Z2V4 carboxykinase, cytosolic C10(Carbamidomethyl); 1 1327.762 1.98 [GTP] K12(HeavyDimethyl) K12(Dimethyl); K15(Dimethyl); YLAPSGPSGTLKAGKATK Q61553 Fascin 1 1831.053 2.27 K18(Dimethyl) YLEENVMRHFALDAAATVAAQR F6YMV1 Angiomotin (Fragment) N-Term(Dimethyl); M7(Oxidation) 1 2520.288 2.55 Angiomotin-like protein N-Term(Dimethyl:2H(6)13C(2)); YLEERAMRQFAMDAAATAAAQR B8JK81 1 2523.253 2.55 2 M7(Oxidation) Isoform 2 of Transforming acidic K6(Dimethyl); K13(Dimethyl); YLEMGKSVDEFEKIAYK Q9JJ11-2 1 2134.085 2.51 coiled-coil-containing K17(Dimethyl) protein 3 N-Term(Dimethyl); YLGGSSCIAGVLVPVQGEPGRQEK Q8R0W0 Epiplakin 2 2557.336 3.03 C7(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YLGGSSCIAGVLVPVQGEPGRQEK Q8R0W0 Epiplakin C7(Carbamidomethyl); 2 2573.423 3.94 K24(HeavyDimethyl) Glutathione S- N-Term(Dimethyl); K5(Dimethyl); YLGRKHNLCGETEEER P19639 1 2047.003 2.47 transferase Mu 3 C9(Carbamidomethyl) Schlafen family member K3(Dimethyl); C4(Carbamidomethyl); YLKCVEDLQKDYFPVSP F8WH72 1 2157.083 2.49 5 (Fragment) K10(Dimethyl) N-Term(Dimethyl); YLLGTSLARPCIAR J3QNG0 MCG15755 7 1618.905 2.58 C11(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YLLGTSLARPCIAR J3QNG0 MCG15755 8 1626.945 2.67 C11(Carbamidomethyl) N-Term(Dimethyl); Proteasome subunit YLLQYQEPIPCEQLVTALCDIK E9PW69 C11(Carbamidomethyl); 3 2750.421 3.35 alpha type (Fragment) C19(Carbamidomethyl); K22(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Proteasome subunit C11(Carbamidomethyl); YLLQYQEPIPCEQLVTALCDIK E9PW69 1 2766.513 3.07 alpha type (Fragment) C19(Carbamidomethyl); K22(HeavyDimethyl) Isoform Soluble of N-Term(Dimethyl); YLPDTLLLEECGLLR O88587-2 Catechol O- 7 1832.977 3.55 C11(Carbamidomethyl) methyltransferase Isoform Soluble of N-Term(Dimethyl:2H(6)13C(2)); YLPDTLLLEECGLLR O88587-2 Catechol O- 4 1841.023 3.05 C11(Carbamidomethyl) methyltransferase Glutaryl-CoA YLPGLAKGELLGCFGLTEPNHGSDPGG N-Term(Dimethyl); K7(Dimethyl); Q60759 dehydrogenase, 4 3329.635 3.60 METR C13(Carbamidomethyl) mitochondrial Glutaryl-CoA N-Term(Dimethyl:2H(6)13C(2)); YLPGLAKGELLGCFGLTEPNHGSDPGG Q60759 dehydrogenase, K7(HeavyDimethyl); 1 3345.723 3.69 METR mitochondrial C13(Carbamidomethyl) Isoform 2 of N-Term(Dimethyl); YLQDAGCPVFLYEFQHTPSSFAK Q63880-2 10 2761.333 6.06 Carboxylesterase 3A C7(Carbamidomethyl); K23(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of YLQDAGCPVFLYEFQHTPSSFAK Q63880-2 C7(Carbamidomethyl); 9 2777.419 5.76 Carboxylesterase 3A K23(HeavyDimethyl) YLRDAGCPVFLYEFQHTPSSFAK Q8VCU1 Carboxylesterase 3B C7(Carbamidomethyl); K23(Dimethyl) 2 2761.335 4.68 YLTLFLITMLILTSANNMFQLFIGWEG NADH-ubiquinone N-Term(Dimethyl:2H(6)13C(2)); P03921 1 4996.577 2.90 VGIMSFLLIGWWYGR oxidoreductase chain 5 M9(Oxidation); M18(Oxidation)

NADH dehydrogenase [ubiquinone] N-Term(Dimethyl); YLVVNADEGEPGTCK D3Z1U9 6 1707.817 3.96 flavoprotein 1, C14(Carbamidomethyl); K15(Dimethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); [ubiquinone] YLVVNADEGEPGTCK D3Z1U9 C14(Carbamidomethyl); 2 1723.905 3.72 flavoprotein 1, K15(HeavyDimethyl) mitochondrial

NADH dehydrogenase [ubiquinone] N-Term(Dimethyl); YLVVNADEGEPGTCKDR D3Z1U9 3 1978.949 2.96 flavoprotein 1, C14(Carbamidomethyl); K15(Dimethyl) mitochondrial

NADH dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); [ubiquinone] YLVVNADEGEPGTCKDR D3Z1U9 C14(Carbamidomethyl); 1 1995.040 2.86 flavoprotein 1, K15(HeavyDimethyl) mitochondrial N-Term(Dimethyl:2H(6)13C(2)); YLYLTPQDYTQISSQNSVHCK E9Q4Z2 Protein Acacb C20(Carbamidomethyl); 1 2617.354 2.79 K21(HeavyDimethyl) STIP1 homology and U N-Term(Dimethyl:2H(6)13C(2)); YMADMDELFSQVDEK Q9WUD1 1 1908.897 2.31 box-containing protein 1 M2(Oxidation); K15(HeavyDimethyl) N-Term(Dimethyl); YMCENQATISSK P07724 Serum albumin 14 1487.682 4.21 C3(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl); M2(Oxidation); YMCENQATISSK P07724 Serum albumin 6 1503.680 3.43 C3(Carbamidomethyl); K12(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YMCENQATISSK P07724 Serum albumin C3(Carbamidomethyl); 4 1503.771 4.30 K12(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); YMCENQATISSK P07724 Serum albumin M2(Oxidation); C3(Carbamidomethyl); 4 1519.768 3.32 K12(HeavyDimethyl) N-Term(Dimethyl); YMILTYLLLMLIVYIFECASCITSYTHR C18(Carbamidomethyl); Q9D132 Uroplakin-1a 1 4908.545 3.36 DYMVSNPSLITK C21(Carbamidomethyl); M31(Oxidation); K40(Dimethyl) Acetylcholine receptor YMLFTMVFVIASIIITVIVINTHHR P04756 M2(Oxidation); M6(Oxidation) 2 2963.644 2.79 subunit alpha YMQKEGCVGEIVVQLSEDLLSQAVM Uncharacterized protein K4(Dimethyl); C7(Carbamidomethyl); Q810A5 1 4710.427 3.85 MVENSRPTLAINLTGAR KIAA0895-like M25(Oxidation); M26(Oxidation) N-Term(Dimethyl); YNAHMVPEDGSLNCLK Q8R0F9 SEC14-like protein 4 1 1903.896 2.49 C14(Carbamidomethyl); K16(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YNAHMVPEDGSLNCLK Q8R0F9 SEC14-like protein 4 C14(Carbamidomethyl); 2 1919.994 2.49 K16(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Isoform 2 of CCR4- C4(Carbamidomethyl); YNECLMNFSCSGK Q8VEG6-2 NOT transcription 1 1681.804 2.12 C10(Carbamidomethyl); complex subunit 6-like K13(HeavyDimethyl) T-cell surface C8(Carbamidomethyl); M9(Oxidation); YNIRDGGCMLLSK P20937 2 1578.799 1.92 glycoprotein YE1/48 K13(HeavyDimethyl) 3-ketoacyl-CoA thiolase, N-Term(Dimethyl); YNISREDCDRYALQSQQR Q8BWT1 2 2330.091 2.86 mitochondrial C8(Carbamidomethyl)

3-ketoacyl-CoA thiolase, N-Term(Dimethyl:2H(6)13C(2)); YNISREDCDRYALQSQQR Q8BWT1 2 2338.127 2.84 mitochondrial C8(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YNLGAPVAGTCYQAEWDDYVPKLYE Phosphatidylethanolami C11(Carbamidomethyl); P70296 1 3543.868 3.00 QLSGK ne-binding protein 1 K22(HeavyDimethyl); K30(HeavyDimethyl) Oxysterol-binding YNLTNTVVCRVQGEWNSVLEFTYSNG C9(Carbamidomethyl); K29(Dimethyl); Q8CI95 protein-related protein 1 4138.070 2.82 ETKFVDLAK K35(Dimethyl) 11 N-Term(Dimethyl); YNLTPTIFFCATPPDDGNLCR Q64442 Sorbitol dehydrogenase C10(Carbamidomethyl); 7 2500.151 4.98 C20(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YNLTPTIFFCATPPDDGNLCR Q64442 Sorbitol dehydrogenase C10(Carbamidomethyl); 11 2508.217 5.02 C20(Carbamidomethyl) Sodium/potassium- N-Term(Dimethyl); YNPNVLPVQCTGK P14094 transporting ATPase 4 1545.809 2.12 C10(Carbamidomethyl); K13(Dimethyl) subunit beta-1 Sodium/potassium- N-Term(Dimethyl:2H(6)13C(2)); YNPNVLPVQCTGK P14094 transporting ATPase C10(Carbamidomethyl); 1 1561.898 1.99 subunit beta-1 K13(HeavyDimethyl) Ankyrin and armadillo YNQDYLDICTYQRLQKR A2RT91 C9(Carbamidomethyl); K16(Dimethyl) 1 2305.130 2.58 repeat-containing protein N-Term(Dimethyl); YNSHMVPEDGTLTCSEPGIYVLR Q99J08 SEC14-like protein 2 4 2666.254 3.53 C14(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YNSHMVPEDGTLTCSEPGIYVLR Q99J08 SEC14-like protein 2 3 2674.289 4.66 C14(Carbamidomethyl) Trinucleotide repeat- K4(HeavyDimethyl); YNYKNVNMWNK F6ZMJ4 containing gene 6A 1 1545.854 1.98 K11(HeavyDimethyl) protein Isoform 3 of Ankyrin YPIFQLVMQYLYYGGPESLLIKNNEIM repeat and BTB/POZ K22(Dimethyl); M27(Oxidation); Q6GQW0-3 1 4021.159 3.34 ELLSAAK domain-containing K34(Dimethyl) protein BTBD11 Protein Smpd5 YPLLRATFRCFPNAR G3UXH6 C10(Carbamidomethyl) 1 1881.964 2.25 (Fragment) Cytosolic 10- N-Term(Dimethyl); YQALGAELNVLPFCSQFIPMEVINAPR Q8R0Y6 formyltetrahydrofolate 13 3105.602 4.64 C14(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl); YQALGAELNVLPFCSQFIPMEVINAPR Q8R0Y6 formyltetrahydrofolate 7 3121.597 4.15 C14(Carbamidomethyl); M20(Oxidation) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); YQALGAELNVLPFCSQFIPMEVINAPR Q8R0Y6 formyltetrahydrofolate 14 3113.646 5.18 C14(Carbamidomethyl) dehydrogenase Cytosolic 10- N-Term(Dimethyl:2H(6)13C(2)); YQALGAELNVLPFCSQFIPMEVINAPR Q8R0Y6 formyltetrahydrofolate 10 3129.646 4.81 C14(Carbamidomethyl); M20(Oxidation) dehydrogenase N-Term(Dimethyl:2H(6)13C(2)); 5-oxoprolinase YQGTDCALMVSANQHPATTCSPR E9Q484 C6(Carbamidomethyl); 1 2601.186 2.68 (Fragment) C20(Carbamidomethyl) NAD(P)H-hydrate N-Term(Dimethyl); YQLNLPSYPDTECVYR Q8K4Z3 2 2045.957 3.06 epimerase C13(Carbamidomethyl) NAD(P)H-hydrate N-Term(Dimethyl:2H(6)13C(2)); YQLNLPSYPDTECVYR Q8K4Z3 2 2054.002 3.71 epimerase C13(Carbamidomethyl) NAD(P)H-hydrate N-Term(Dimethyl); YQLNLPSYPDTECVYRLQ Q8K4Z3 3 2287.111 3.57 epimerase C13(Carbamidomethyl) NAD(P)H-hydrate N-Term(Dimethyl:2H(6)13C(2)); YQLNLPSYPDTECVYRLQ Q8K4Z3 3 2295.152 3.71 epimerase C13(Carbamidomethyl) Isoform Mt-VDAC1 of Voltage-dependent anion-N-Term(Dimethyl); YQVDPDACFSAK Q60932-2 11 1456.671 2.76 selective channel protein C8(Carbamidomethyl); K12(Dimethyl) 1 Isoform Mt-VDAC1 of N-Term(Dimethyl:2H(6)13C(2)); Voltage-dependent anion- YQVDPDACFSAK Q60932-2 C8(Carbamidomethyl); 9 1472.766 2.88 selective channel protein K12(HeavyDimethyl) 1 N-Term(Dimethyl); YRCELLYEGPPDDEAAMGIK P58252 Elongation factor 2 2 2383.132 4.06 C3(Carbamidomethyl); K20(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YRCELLYEGPPDDEAAMGIK P58252 Elongation factor 2 C3(Carbamidomethyl); 4 2399.212 3.55 K20(HeavyDimethyl) YRPASASVSALIGAPDGLISLLRTYEFK Q5ND50 Adapter molecule crk K28(HeavyDimethyl) 1 3031.707 3.04 N-Term(Dimethyl:2H(6)13C(2)); Canalicular multispecific K10(HeavyDimethyl); YRPELDLVLKGITCNIK Q8VI47 organic anion transporter 1 2140.366 2.69 C14(Carbamidomethyl); 1 K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Indoleamine 2,3- YSGGSAAQSSVLHAFDEFLGIEHCK Q8R0V5 C24(Carbamidomethyl); 1 2782.413 2.79 dioxygenase 2 K25(HeavyDimethyl) Peroxisomal bifunctional N-Term(Dimethyl); YSPIADMLCEAGR Q9DBM2 4 1510.699 2.74 enzyme C9(Carbamidomethyl) Peroxisomal bifunctional N-Term(Dimethyl:2H(6)13C(2)); YSPIADMLCEAGR Q9DBM2 4 1518.751 3.17 enzyme C9(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Peroxisomal bifunctional YSPIADMLCEAGRFGQK Q9DBM2 C9(Carbamidomethyl); 1 2015.076 2.20 enzyme K17(HeavyDimethyl) N-Term(Dimethyl); YSQVGTQECAIVEFEEVDAAIKAHEFM Q8BN59 La-related protein 6 C9(Carbamidomethyl); K22(Dimethyl); 1 3944.863 3.52 VTESQSK K34(Dimethyl) YSRDVPFFEMLVPTTDTVRYGYLMEK D3YWN4 Protein Dnah6 M24(Oxidation); K26(HeavyDimethyl) 1 3209.588 3.43 Glutamate N-Term(Dimethyl); K11(Dimethyl); YSTDVSVDEVKALASLMTYKCAVVD P26443 dehydrogenase 1, K20(Dimethyl); C21(Carbamidomethyl); 1 3532.857 4.16 VPFGGAK mitochondrial K32(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); Glutamate K11(HeavyDimethyl); YSTDVSVDEVKALASLMTYKCAVVD P26443 dehydrogenase 1, K20(HeavyDimethyl); 4 3565.027 4.79 VPFGGAK mitochondrial C21(Carbamidomethyl); K32(HeavyDimethyl) YSVGSLVDSQSDYRTTKVIR B8QI34 Liprin-alpha 2 K17(Dimethyl) 1 2302.170 2.39 N-Term(Dimethyl:2H(6)13C(2)); Gem-associated protein YTLFSTSAEGHNHSRIVFNLCSLK F7CKD6 C21(Carbamidomethyl); 1 2853.508 2.57 5 (Fragment) K24(HeavyDimethyl) Guanine nucleotide- N-Term(Dimethyl); YTVQDESHSEWVSCVR P68040 binding protein subunit 12 2009.900 5.72 C14(Carbamidomethyl) beta-2-like 1 Guanine nucleotide- N-Term(Dimethyl:2H(6)13C(2)); YTVQDESHSEWVSCVR P68040 binding protein subunit 9 2017.950 5.11 C14(Carbamidomethyl) beta-2-like 1 40S ribosomal protein N-Term(Dimethyl); YVDIAIPCNNK P14206 7 1362.704 2.97 SA C8(Carbamidomethyl); K11(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); 40S ribosomal protein YVDIAIPCNNK P14206 C8(Carbamidomethyl); 6 1378.793 3.21 SA K11(HeavyDimethyl) Cytochrome P450, N-Term(Dimethyl); YVDLGPISLVHEVTCDTKFR Q569X9 family 2, subfamily c, 2 2405.260 3.44 C15(Carbamidomethyl); K18(Dimethyl) polypeptide 67 Cytochrome P450, N-Term(Dimethyl:2H(6)13C(2)); YVDLGPISLVHEVTCDTKFR Q569X9 family 2, subfamily c, C15(Carbamidomethyl); 1 2421.341 2.59 polypeptide 67 K18(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); Cell division control YVECSALTQK P60766 C4(Carbamidomethyl); 3 1270.728 2.20 protein 42 homolog K10(HeavyDimethyl) N-Term(Dimethyl); YVEPIEDVPCGNIVGLVGVDQFLVK P58252 Elongation factor 2 6 2815.531 4.63 C10(Carbamidomethyl); K25(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YVEPIEDVPCGNIVGLVGVDQFLVK P58252 Elongation factor 2 C10(Carbamidomethyl); 11 2831.593 5.78 K25(HeavyDimethyl) Epithelial-splicing YVEVVPCSTEEMSRVLMGGSLSR D3Z139 regulatory protein 2 C7(Carbamidomethyl) 2 2586.243 2.90 (Fragment) Short-chain N-Term(Dimethyl); YVFITGCDSGFGNLLAK Q8K3P0 dehydrogenase/reductase 2 1917.957 2.71 C7(Carbamidomethyl); K17(Dimethyl) family 9C member 7 N-Term(Dimethyl); YVFITGCDSGFGNLLAR Q6PHA1 Protein Rdh9 12 1917.949 4.84 C7(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); YVFITGCDSGFGNLLAR Q6PHA1 Protein Rdh9 26 1926.006 5.22 C7(Carbamidomethyl) Alpha-1,2- YVFQVASGILCSLPVRSVHGVCELHHP C11(Carbamidomethyl); H3BJK6 mannosyltransferase 1 3720.876 2.85 EASESK C22(Carbamidomethyl); K33(Dimethyl) ALG9 (Fragment) Pre-mRNA-splicing C19(Carbamidomethyl); YVRMLGALYMRLTGTAIDCYK Q4FK66 1 2531.302 2.40 factor 38A K21(HeavyDimethyl) YVRPGGGFEPNFTLFEKCEVNGEKAHP N-Term(Dimethyl); K17(Dimethyl); P11352 Glutathione peroxidase 1 1 3940.965 3.24 LFTFLR C18(Carbamidomethyl); K24(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YVRPGGGFEPNFTLFEKCEVNGEKAHP K17(HeavyDimethyl); P11352 Glutathione peroxidase 1 1 3965.138 2.88 LFTFLR C18(Carbamidomethyl); K24(HeavyDimethyl) YVSHGATGKGNDQVRFELTCYSLAPQI N-Term(Dimethyl); K9(Dimethyl); J3QNG0 MCG15755 17 3223.663 5.57 K C20(Carbamidomethyl); K28(Dimethyl) N-Term(Dimethyl:2H(6)13C(2)); YVSHGATGKGNDQVRFELTCYSLAPQI K9(HeavyDimethyl); J3QNG0 MCG15755 16 3247.787 5.69 K C20(Carbamidomethyl); K28(HeavyDimethyl) Isoform 3 of N-Term(Dimethyl:2H(6)13C(2)); YVTGNPRDHATMK Q692V3-3 Tetratricopeptide repeat 1 1561.893 2.14 K13(HeavyDimethyl) protein GNN Phosphatidylethanolami N-Term(Dimethyl); YVWLVYEQEQPLSCDEPILSNK P70296 3 2766.387 4.80 ne-binding protein 1 C14(Carbamidomethyl); K22(Dimethyl) Ectonucleotide pyrophosphatase/phosph YVYLNKYLGDVNNVKVVYGPAAR G3X9S2 K6(Dimethyl); K15(Dimethyl) 1 2671.423 2.80 odiesterase 1, isoform CRA_d N-acyl-aromatic-L- N-Term(Dimethyl:2H(6)13C(2)); YWLQNPGELQRPSFSAMPVLANPAAT amino acid Q91XE4 C29(Carbamidomethyl); 1 3512.765 3.50 AACCR amidohydrolase C30(Carbamidomethyl) (carboxylate-forming) Putative bifunctional K7(HeavyDimethyl); UDP-N- C8(Carbamidomethyl); YYFLGDKCQVCMESGGK Q9D8C3 acetylglucosamine 1 2130.000 2.22 C11(Carbamidomethyl); transferase and M12(Oxidation); K17(HeavyDimethyl) deubiquitinase ALG13 Serine N-Term(Dimethyl); YYGGAEVVDEIELLCQR Q9CZN7 hydroxymethyltransferas 2 2041.991 2.93 C15(Carbamidomethyl) e Serine N-Term(Dimethyl:2H(6)13C(2)); YYGGTEFIDELEMLCQK G3UZ26 hydroxymethyltransferas C15(Carbamidomethyl); 1 2168.080 2.22 e (Fragment) K17(HeavyDimethyl) N-Term(Dimethyl:2H(6)13C(2)); YYQLGCWGPGLPLYTLHR P28843 Dipeptidyl peptidase 4 1 2230.164 2.35 C6(Carbamidomethyl) Heat shock protein HSP N-Term(Dimethyl); K14(Dimethyl); YYTSASGDEMVSLKDYCTR P07901 4 2302.032 5.50 90-alpha C17(Carbamidomethyl) N-Term(Dimethyl:2H(6)13C(2)); Heat shock protein HSP YYTSASGDEMVSLKDYCTR P07901 K14(HeavyDimethyl); 2 2318.122 4.27 90-alpha C17(Carbamidomethyl) YYYTREILGTALALARASALCLNFNSM Isoform 3 of NADPH C21(Carbamidomethyl); Q8CIZ9-3 2 4065.085 2.90 MILIPVCR oxidase 1 C34(Carbamidomethyl) a Peptides are grouped by sequence and mass. b Accession number provided from the Uniprot mouse database (05/21/2014, 51344 sequences). c Spectral counts. d Molecular weight. e Xcorr provided from SEQUEST HT searching engine.