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Home , Aldolase B, Chalcone synthase, Deoxyribonuclease I, DNA glycosylase, Glucocerebrosidase, Nucleotidase

Introduction The terms in the Subject Index for Volume 81, January-December 1984, of the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA (Biological Sci- ences) were chosen from titles, key terms, and abstracts of articles. The index terms are alphabetized by computer; numbers, conformational prefixes, and hy- phenated Greek letters are disregarded in alphabetization.

8041 8042 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

A* Different channel properties of Torpedo acetylcholine receptor monomers Cleavage of single-stranded DNA by the

Cloning of the bronze locus in maize by a simple and generalizable Adenovirus tripartite leader sequence enhances translation of mRNAs procedure using the transposable controlling element Activator late after infection, 3655 (Ac), 3825 Altered mRNA splicing in monkey cells abortively infected with human Active fragment adenovirus may be responsible for inefficient synthesis of the virion Biologic activity in a fragment of recombinant human interferon a, 1045 fiber polypeptide, 4023 Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate Human liver alcohol dehydrogenase: substitution in the PA viral ElIa and EIII expression at the transcriptional level, 4381 Oriental explains functional properties, establishes an active In vitro-synthesized adenovirus 2 messenger RNA precursors are site structure, and parallels mutational exchanges in the yeast accurately spliced by nuclear extracts, 4707 , 3024 Transformation properties of type 5 adenovirus mutants that differentially Active-site carbamate formation and reaction-intermediate-analog binding express the ElA gene products, 5734 by ribulosebisphosphate carboxylase/oxygenase in the absence of its Isolation of an active transcription initiation complex from HeLa cell-free small subunits, 3660 extract, 5916 Active transport Pausing and premature termination of human RNA II during See also Transport transcription of adenovirus in vivo and in vitro, 5931 Development of methotrexate resistance in a human squamous cell Homology of adenoviral E3 glycoprotein with HLA-DR heavy carcinoma of the head and neck in culture, 2873 chain, 6039 Development of methotrexate resistance in a human squamous cell Proximal and distal domains that control in vitro transcription of the carcinoma of the head and neck in culture (Correction), 5006 adenovirus IVa2 gene, 6290 Monomeric solubilized sarcoplasmic reticulum Ca pump protein: Synthesis in Escherichia coli of human adenovirus type 12 transforming Demonstration of Ca binding and dissociation coupled to ATP proteins encoded by early region 1A 13S mRNA and 12S mRNA, 6300 Use of adeno-associated virus as a mammalian DNA cloning vector: , 6623 Transduction of neomycin resistance into mammalian tissue culture ATP-binding sites in the membrane components of the histidine cells, 6466 permease, a periplasmic transport system, 7333 Regulation of polyomavirus transcription by large tumor antigen, 6919 Actomyosin Functions of purified ElA protein microinjected into mammalian X-ray evidence for two structural states of the actomyosin cross-bridge in cells, 6988 muscle fibers, 2364 Adenovirus DNA Acute Intermittent porphyria Isolation of human DNA sequences that bind to nuclear factor I, a host Molecular cloning of a cDNA sequence complementary to protein involved in adenovirus DNA replication, 4013 porphobilinogen deaminase mRNA from rat, 5036 Adenovirus-simlan virus 40 hybrid Acute lymphocytic leukemia Efficient coupled transcription and mRNA splicing in vitro using plasmids Translocation and rearrangement of c-myc into immunoglobulin a heavy derived from early region 3 of adenovirus 2 and a nondefective chain locus in primary cells from acute lymphocytic leukemia, 5514 adenovirus-simian virus 40 hybrid, 2679 Acute-phase reactant Adenylate cyclase Effect of radiation on production of epidermal cell thymocyte- Inhibition of opiate receptor-mediated signal transmission by rabies virus activating factor/interleukin 1 in vivo and in vitro, 1198 in persistently infected NG-108-15 mouse neuroblastoma-rat glioma Acyclovir hybrid cells, 950 6-Deoxyacyclovir: A xanthine oxidase-activated prodrug of Properties of rat anterior pituitary vasopressin receptors: Relation to acyclovir, 3209 adenylate cyclase and the effect of corticotropin-releasing factor, 2907 Adaptation Phorbol ester induces desensitization of adenylate cyclase and Understanding biological computation: Reliable learning and phosphorylation of the 0-adrenergic receptor in turkey recognition, 6871 erythrocytes, 4316 Adaptive response Identification of receptors in rat brain, 4368 Adaptive response in mammalian cells: Crossreactivity of different Influence of the P-adrenergic receptor concentration on functional pretreatments of cytotoxicity as contrasted to mutagenicity, 1062 coupling to the adenylate cyclase system, 4637 Induction of specific Escherichia coli genes by sublethal treatments with Binding of [3Hforskolin to rat brain membranes, 5081 alkylating agents, 4110 Pertussis toxin differentiates between two mechanisms of attenuation of Adaptive value cyclic AMP accumulation by muscarinic cholinergic receptors, 5680 Self-organization in macromolecular systems: The notion of adaptive Stimulatory GTP regulatory unit Ns and the catalytic unit of adenylate value, 6068 cyclase are tightly associated: Mechanistic consequences, 6579 Adeno-associated virus Functional alteration of the S-adrenergic receptor during desensitization Use of adeno-associated virus as a mammalian DNA cloning vector: of mammalian adenylate cyclase by ,-agonists, 6686 Transduction of neomycin resistance into mammalian tissue culture Both cholera toxin-induced adenylate cyclase activation and cholera toxin cells, 6466 biological activity are inhibited by antibodies against related synthetic Adenocarcinoma , 7893 Detection of a pancreatic -associated antigen (DU-PAN-2 antigen) (2'-5')Adenylyladenosine in serum and ascites of patients with adenocarcinoma, 5242 Immunological evidence for the in vivo occurrence of (2'- 5')adenylyladenosine oligonucleotides in and Regioselective arylation of ribose in adenosine and with the prokaryotes, 2322 antitumor drug N2-methyl-9-hydroxyellipticinium , 1297 Adenylylation Adenosine-dependent activation of tyrosine hydroxylase is defective in Separation of synthetase species with different states of adenosine kinase-deficient PC12 cells, 4974 adenylylation by chromatography on monoclonal anti-AMP antibody Adenosine strongly potentiates pressor responses to nicotine in rats, 5599 affinity columns, 4677 Adenosine release from stimulated mast cells, 6192 Specific in vitro adenylylation of the simian virus 40 large tumor Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in antigen, 6574 rat cerebellar cortex, 6531 Adhesion Adenosine deaminase Two antigenically related neuronal cell adhesion molecules of different Conversion of a stem cell leukemia from a T-lymphoid to a myeloid specificities mediate neuron-neuron and neuron-glia adhesion, 267 phenotype induced by the adenosine deaminase inhibitor 2'- Evolutionary conservation of key structures and binding functions of deoxycoformycin, 253 neural cell adhesion molecules, 6881 Antileukemic and immunosuppressive activity of 2-chloro-2'- Adhesion plaque deoxyadenosine, 2232 Localization of the GD2 and GD3 in adhesion plaques and on Adenosine kinase the surface of human melanoma cells, 5767 Adenosine-dependent activation of tyrosine hydroxylase is defective in Adipocyte adenosine kinase-deficient PC12 cells, 4974 Hormonal regulation of hormone-sensitive in intact adipocytes: Adenosinetriphosphatase Identification of phosphorylated sites and effects on the See ATPase phosphorylation by lipolytic hormones and insulin, 3317 S-Adenosylhomocysteine Insulin activates the appearance of insulin-like growth factor II receptors Conversion of a stem cell leukemia from a T-lymphoid to a myeloid on the adipocyte cell surface, 4028 phenotype induced by the adenosine deaminase inhibitor 2'- obl7 cells transformed by the middle-T-only gene of polyoma virus deoxycoformycin, 253 differentiate in vitro and in vivo into adipose cells, 5440 S-Adenosylmethionine Expression of specific mRNAs during adipose differentiation: Glycine N-methyltransferase is a folate binding protein of rat liver Identification of an mRNA encoding a homologue of myelin P2 , 3631 protein, 5468 Adenovirus Identification of the a,8 monomer of the adipocyte insulin receptor by Template requirements for the initiation of adenovirus DNA insulin binding and autophosphorylation, 7693 replication, 100 Adipose tissue Rapid recovery of body mass after surgical removal of adipose tissue in Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection, 1193 ground squirrels, 2270 Efficient coupled transcription and mRNA splicing in vitro using plasmids Adiposity derived from early region 3 of adenovirus 2 and a nondefective Effects of food restriction on aging: Separation of food intake and adenovirus-simian virus 40 hybrid, 2679 adiposity, 1835 DNA methylation of three 5' C-C-G-G 3' sites in the and 5' ADP region inactivate the E2a gene of adenovirus type 2, 2950 ADP-dependent common receptor mechanism for binding of von DNA sequences required for the in vitro replication of adenovirus Willebrand factor and fibrinogen to human platelets, 4935 DNA, 3069 8044 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

ADP-ribosylation Aggssion Cloning, sequence, and expression in Escherichia coli of the Seasonal aggression independent of seasonal testosterone in wood exotoxin A structural gene of Pseudomonas aeruginosa, 2645 rats, 5255 NAD of diphtheria toxin: Identification of a residue within Aging the nicotinamide subsite by photochemical modification with Modification of DNA by reducing sugars: A possible mechanism for NAD, 3307 aging and age-related dysfunction in gene expression, 105 Nonenzymic ADP-ribosylation of specific mitochondrial Accelerated age-related browning of human collagen in diabetes polypeptides, 3929 mellitus, 583 ADP-ribosyltransferase Effects of food restriction on aging: Separation of food intake and Cellular ADP-ribosyltransferase with the same mechanism of action as adiposity, 1835 diphtheria toxin and Pseudomonas toxin A, 2703 Calmodulin inhibitor in senescing apples and its physiological and Adrenal pharmacological significance, 2065 Intramitochondrial movement of adrenal sterol carrier protein with Aging of proteins: Isolation and identification of a fluorescent cholesterol in response to corticotropin, 2970 chromophore from the reaction of polypeptides with , 2684 Changes in rat adrenal catecholamines and proenkephalin Dopamine receptor turnover rates in rat striatum are age-dependent, 3910 after denervation, 3587 Functional history of two motor neurons and the morphometry of their neuromuscular junctions in the gill of Aplysia: Evidence for differential Adrenal cortex aging, 4232 Molecular cloning and nucleotide sequence of cDNA for mRNA of glycol and thymidine glycol in human and rat urine: A possible mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex, 4647 assay for oxidative DNA damage, 5633 Adrenal gland Localization of senescent cell antigen on band 3, 5753 Denervation of rat adrenal glands markedly increases preproenkephalin Inhibition by restricted-calorie diet of lymphoproliferative disease and mRNA, 7221 renal damage in MRLApr mice, 6144 Intact proenkephalin is the major enkephalin-containing produced Glucocorticoid-sensitive hippocampal neurons are involved in terminating in rat adrenal glands after denervation, 7985 the adrenocortical stress response, 6174 Adrenal hyperplasia Isolated uterine nuclei and cytosol receptors of aged rats exhibit impaired HLA-linked congenital adrenal hyperplasia results from a defective gene estrogenic stimulation of RNA polymerase II, 7481 encoding a cytochrome P450 specific for steroid 21- Carotenoids and retinol: Their possible importance in determining hydroxylation, 7505 longevity of primate species, 7627 Adrenalectomy Agmenellum Corticotropin-releasing factor-immunoreactive neurons of the Cloning and sequencing of the genes encoding the a and f8 subunits of C- paraventricular nucleus become vasopressin positive after phycocyanin from the cyanobacterium Agmenellum adrenalectomy, 1854 quadruplicatum, 6983 Adrenergic receptor Genes for the a and (3 subunits of phycocyanin, 7946 Monoclonal antibodies detect the conservation of muscarinic cholinergic Agouti phenotype receptor structure from Drosophila to human brain and detect possible Differential effects of the mottled yellow and pseudoagouti phenotypes on structural homology with a1-adrenergic receptors, 272 immunocompetence in AvY/a mice, 2152 Quantitative autoradiography of (8- and P2-adrenergic receptors in rat Agrobacterium brain, 1585 Nucleotide sequence of the tms genes of the pTiA6NC octopine Ti Phorbol ester induces desensitization of adenylate cyclase and plasmid: Two gene products involved in plant tumorigenesis, 1728 phosphorylation of the P-adrenergic receptor in turkey Identification of a cloned cytokinin biosynthetic gene, 4776 erythrocytes, 4316 Crown gall oncogenesis: Evidence that a T-DNA gene from the Influence of the (3-adrenergic receptor concentration on functional Agrobacterium Ti plasmid pTiA6 encodes an enzyme that catalyzes coupling to the adenylate cyclase system, 4637 synthesis of indoleacetic acid, 5071 Functional alteration of the 83-adrenergic receptor during desensitization T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin of mammalian adenylate cyclase by (-agonists, 6686 biosynthesis, 5994 Adrenergic response Alanine Potentiation of a1-adrenergic responses in rat liver by a cAMP-dependent Requirement for alanine in the amino acid control of deprivation-induced mechanism, 4208 protein degradation in liver, 4270 Adrenoceptor D-Alanyl-D-alanine transpeptidase Time-dependent conversion of a,- to ,3-adrenoceptor-mediated f-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl in isolated rat liver cells: Role of membrane transfer to specific amino acid acceptors, 1302 A2, 6178 Albino Adrenocorticotropin Mice homozygous for chromosomal deletions in the albino locus region Carboxypeptidase B-like converting enzyme activity in secretory granules lack specific polypeptides in two-dimensional gels, 2132 of rat pituitary, 2776 Albumin Adrenodoxin Hepatitis B surface antigen and polymerized albumin binding activity in Camphor hydroxylase of Pseudomonas putida: Vestiges of sequence sheep serum, 564 homology in cytochrome P450CAM' putidaredoxin, and related Albumin extinction without methylation of its gene, 1738 proteins, 1664 Interactions of myristic acid with bovine serum albumin: A '3C NMR Adrenoleukodystrophy study, 3718 Lignoceric acid is oxidized in the peroxisome: Implications for the Differential DNase I sensitivity of the albumin and a-fetoprotein genes in Zellweger cerebro-hepato-renal syndrome and from rat tissues and cell lines, 5031 adrenoleukodystrophy, 4203 Quantitative assay for albumin-producing liver cells after simian virus 40 Adult T-cell leukemia/lymphoma transformation of rat hepatocytes maintained in chemically defined Pseudotypes of human T-cell leukemia virus types 1 and 2: Neutralization medium, 6378 by patients' sera, 2886 Synthesis in animal cells of hepatitis B surface antigen particles carrying Human T-cell leukemia virus-associated membrane antigens: Identity of a receptor for polymerized human serum albumin, 7708 the major antigens recognized after virus infection, 3856 Albumin locus Genomes of evolutionarily divergent members of the human T-cell Linkage disequilibrium and evolutionary relationships of DNA variants leukemia virus family (HTLV-I and HTLV-II) are highly conserved, ( fragment length polymorphisms) at the serum especially in pX, 4544 albumin locus, 3486 Repetitive structure in the long-terminal-repeat element of a type II Alcohol dehydrogenase human T-cell leukemia virus, 4617 Cloned Drosophila alcohol dehydrogenase genes are correctly expressed Retrovirus-induced expression of interleukin 2 receptors on cells of after transfection into Drosophila cells in culture, 1701 human B-cell lineage, 7441 Human liver alcohol dehydrogenase: Amino acid substitution in the t32/32 Serological cross-reactivity between envelope gene products of type I and Oriental isozyme explains functional properties, establishes an active type II human T-cell leukemia virus, 7579 site structure, and parallels mutational exchanges in the yeast Infection of human endothelial cells by human T-cell leukemia virus type enzyme, 3024 I, 7591 Molecular cloning and characterization of a cDNA cloning for the P Adult T-cell leukemia/lymphoma virus subunit of human alcohol dehydrogenase, 4055 Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured DNA insertion in the first of maize Adhl affects message levels: cells of patients with adult T-cell leukemia, 6207 Cloning of progenitor and mutant Adhl alleles, 4125 Aeropyle crown Cytoplasmic acidosis as a determinant of flooding intolerance in Molecular cloning of region-specific chorion-encoding RNA plants, 6029 sequences, 27% Human alcohol dehydrogenase: Structural differences between the ,B and Aeschynomene y subunits suggest parallel duplications in isoenzyme evolution and Expression of (-galactosidase controlled by a nitrogenase promoter in predominant expression of separate gene descendants in livers of stem nodules of Aeschynomene scabra, 5806 different mammals, 6320 Aflatoxin Alcohol sensitivity Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene Molecular abnormality of an inactive aldehyde dehydrogenase variant sequences of rat liver DNA, 664 commonly found in Orientals, 258 High-affinity monoclonal antibodies for aflatoxins and their application to Alcoholism solid-phase immunoassays, 7728 Toward an analogue of alcoholism in mice: Scale factors in the Africa model, 3543 Evidence for the multicentric origin of the sickle cell hemoglobin gene in Alcyonium Africa, 1771 Water flow and coral colony size: Interhabitat comparisons of the octocoral Alcyonium siderium, 5473 Biological Sciences Subject Index Proc. NatL Acad2 Sci. USA 81 (1984) 8045

Aldehyde Alveolar cell Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a Endocytosis in alveolar type II cells: Effect of charge and size of particulate preparation from Pisum sativum, 6613 tracers, 6054 Aldehyde dehydrogae Uptake of lectins by pulmonary alveolar type II cells: Subsequent Molecular abnormality of an inactive aldehyde dehydrogenase variant deposition into lamellar bodies, 6383 commonly found in Orientals, 258 Alzheimer disease Aldolase Microtubule-associated protein 2: Monoclonal antibodies demonstrate the Complete amino acid sequence for human aldolase B derived from cDNA selective incorporation of certain epitopes into Alzheimer and genomic clones, 2738 neurofibrillary tangles, 7941 Alfalfa mosaic virus a-Amanltin Striking similarities in amino acid sequence among nonstructural proteins Optimal conditions for cell-free synthesis of citrus exocortis viroid and encoded by RNA viruses that have dissimilar genomic the question of specificity of RNA polymerase activity, 4429 organization, 4358 a-Amanitin-insensitive transcription of mouse Pdior-globin Y'-flanking Ala and structural gene sequences correlates with mRNA expression, 7782 Modulation of chloroplast movement in the green alga Mougeotia by the Amber nonsense suppressor Ca2' ionophore A23187 and by calmodulin antagonists, 6368 The sup-7(stS5) X gene of Caenorhabditis elegans encodes a tRNATFUG amber suppressor, 6784 In vivo effects of microinjected alkaline phosphatase and its low Amblyopia molecular weight substrates on the first meiotic cell division in Labile nature of the visual recovery promoted by reverse occlusion in Xenopus laevis oocytes, 5150 monocularly deprived kittens, 286 Structural analysis of human adult and fetal alkaline by Effects of monocular deprivation on the lateral geniculate nucleus in a cyanogen bromide peptide mapping, 6120 primate, 2255 Heat-labile alkaline phosphatase from Antarctic bacteria: Rapid 5' end- Ambystoma labeling of nucleic acids, 6691 Perpendicular orientation and directional migration of amphibian neural Alkane biosynthesis crest cells in dc electrical fields, 160 Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a Ameba particulate preparation from Pisum sativum, 6613 Chemically defined media for cultivation of Naegleria gruberi, 2406 1-Alkyl-2-acetyl-sx-glycero-3-phosphocholine Amildation Human endothelial cells in culture produce platelet-activating factor Glycine-directed peptide amidation: Presence in rat brain of two (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 thrombin, 3534 (thyrotropin-releasing hormone), 3228 Alkylating agent Amiloride Induction of specific Escherichia coli genes by sublethal treatments with Inhibition of Na+/Ca2' exchange in membrane vesicle and papillary alkylating agents, 4110 muscle preparations from guinea pig heart by analogs of amiloride, 3238 Allelic indusion Inhibition of epidermal growth factor-induced mitogenesis by amiloride Allelic inclusion in the pre-B-cell line 18-81, 867 and an analog: Evidence against a requirement for Na+/H+ Allelic state exchange, 6762 Drift and with a finite number of allelic states, 530 Na+-H+ exchange in gastric glands as measured with a cytoplasmic- Allergy trapped, fluorescent pH indicator, 7436 Properties of a human immunoglobulin E-chain fragment synthesized in Amine transport Escherichia col, 2955 Spiperone: Evidence for uptake into secretory granules, 1867 Expression of a biologically active fragment of human IgE E chain in Amino acid Escherichia coli, 5369 Use of peptide synthesis to probe viral antigens for epitopes to a Allograft resolution of a single amino acid, 3998 Prevention of rejection of murine islet allografts by pretreatment with Amino acid biosynthesis anti-dendritic cell antibody, 3864 5' untranslated sequences are required for the translational control of a Allomery yeast regulatory gene, 5096 Snail shape and growth rates: Evidence for plastic shell allometry in Evidence for translational regulation of the activator of general amino Littorina littorea, 811 acid control in yeast, 6442 Allotype a-Amino group A genomic gene encoding the bS rabbit immunoglobulin K constant Role of the a-amino group of protein in ubiquitin-mediated protein region: Implications for latent allotype phenomenon, 1789 breakdown, 7021 K-chain allotypes and isotypes in the rabbit; cDNA sequences of clones 3-Amino-1-[m-(trlluoremethyl)phenylJ-2-pyrazoline encoding b9 suggest an evolutionary pathway and possible role of the Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor interdomain disulfide bond in quantitative allotype expression, 1794 BW755C, 2890 Allotype suppression Amino-terminal residue Induction of idimunoglobulin allotypic suppression in the rabbit: A On the amino acid sequence of cytochrome P450 isozyme 4 from rabbit cellular approach, 2859 liver microsomes, 4260 Allozyme Aminoacyl-tRNA synthetase Mercury selection of allozymes in marine organisms: Prediction and Transfer RNA mischarging mediated by a mutant Escherichia coli verification in nature, 1258 glutaminyl-tRNA synthetase, 5076 N-Allylnormetazocine 3-Aminobenzamide a opiates andcertain antipsychotic drugs mutually inhibit (+)-[3H]SKF Inhibition of malignant transformation in vitro by inhibitors of poly(ADP- 10,047 and [ Hihaloperidol binding in guinea pig brain membranes, 5618 ribose) synthesis, 243 Alpha cell -Aminobutyric add Conversion of proglucagorl in pancreatic alpha cells: The major Increase in the of y-aminobutyric acid-A recognition sites in brain endproducts are glucagon and a single peptide, the major proglucagon regions of miceBnmxreceiving diazepam, 2247 fragment, that contains two glucagon-like sequences, 5007 Intrinsic GABAergic system of adrenal chromaffin cells, 3218 a factor Antibodies against '-taminobutyric acid; Specificity studies and a-Factor-directed synthesis and secretion of mature foreign proteins in immunocytochemical results, 3888 Saccharomyces cerevisiae, 4642 Numbers of specific types of neuron in layer IVab of cat striate Secretion of foreign proteins from Saccharomyces cerevisiae directed by cortex, 3898 a-factor gene fusions, 5330 Homonuclear 1H double-resonance difference spectroscopy of the rat Alphavirus brain in vivo, 6330 An evolutionary tree relating eight alphaviruses, based on amino-terminal Neuropeptide-containing neurons of the cerebral cortex are also sequences of their glycoproteins, 4702 GABAergic, 6526 Altitude adaptation Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in Biochemical and physiological correlates of deer mouse a-chain rat cerebellar cortex, 6531 hemoglobin polymorphisms, 5484 Immunohistochemical evidence for the coexistence of histidine Altruism decarboxylase-like and -like On the evolution of altruism by kin selection, 1754 immunoreactivities in nerve cells of the magnocellular nucleus of the Group selection for a polygenic behavioral trait: Estimating the degree of posterior hypothalamus of rats, 7647 population subdivision, 6073 yAminobutyric acid acts at axon terminals of turtle photoreceptors: Alu repetitive sequence Difference in sensitivity among cell types, 7961 Structural analysis of the gene encoding human gastrin: The large intron 1-Aminocyclopropane-1-carboxylic acid contains an Alu sequence, 4662 Lipid peroxidation forms ethylene from 1-aminocyclopropane-1- Molecular cloning and the total nucleotide sequence of the human c-Ha- carboxylic acid and may operate in leaf senescence, 1724 ras-1 gene activated in a melanoma from a Japanese patient, 4771 Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic Distinctive sequence organization and functional programming of an Alu acid during its conversion to ethylene, 3059 repeat promoter, 5291 6-Aminohexanoic acid linear oligomer Aluminum Birth of a unique enzyme from an alternative reading frame of the Imaging of calcium and aluminum in neurofibrillary tangle-bearing preexisted, internally repetitious coding sequence, 2421 neurons in parkinsonism-dementia of Guam, 1875 Aminonialonc acd Imaging of calcium and aluminum in neurofibrillary tangle-bearing Aminomalonic acid: Identification in Escherichia coli and atherosclerotic neurons in parkinsonism-dementia of Guam (Correction), 4240 plaque, 722 8046 Biological Sciences Subject Index Proc. NatL Acad Sci. USA 81 (1984) Amnesia Antennapedia Hippocampal denervation causes rapid forgetting of olfactory information Structural relationships among genes that control development: Sequence in rats, 5885 homology between the Antennapedia, Ultrabithorax, and fushi tarazu AMP loci of Drosophila, 4115 Separation of glutamine synthetase species with different states of Andseraea adenylylation by chromatography on monoclonal anti-AMP antibody Cyclic GMP may serve as a second messenger in peptide-induced muscle affinity columns, 4677 degeneration in an insect, 6718 Specific in vitro adenylylation of the simian virus 40 large tumor Anthozoa antigen, 6574 Water flow and coral colony size: Interhabitat comparisons of the Amphibian octocoral Alcyonium siderium, 5473 Natural interspecies transfer of mitochondrial DNA in amphibians, 5802 Anthricnose Amphotropic vFrus 4070A Differential induction of chalcone synthase mRNA activity at the onset of High-efficiency gene transfer into mammalian cells: Generation of helper- phytoalexin accumulation in compatible and incompatible plant- free recombinant retrovirus with broad mammalian host range, 6349 pathogen interactions, 3384 Amyloidosis Anthropology Primary structure of an amyloid prealbumin and its plasma precursor in a Fossil vertebrates from Antigua, Lesser Antilles: Evidence for late heredofamilial polyneuropathy of Swedish origin, 694 Holocene human-caused extinctions in the West Indies, 4448 Anabaena Anti-idlotypic antibody Construction of shuttle vectors capable of conjugative transfer from Sendai virus-specific T-cell clones: Induction of cytolytic T cells by an Escherichia coli to nitrogen-fixing filamentous cyanobacteria, 1561 anti-idiotypic antibody directed against a helper T-cell clone, 2850 Cotranscription of genes encoding the small and large subunits of Induction of immunity to a human tumor marker by in vivo ribulose-1,5-bisphosphate carbdxylase in the cyanobacterium Anabaena administration of anti-idiotypic antibodies in mice, 2864 7120, 5961 Anti-interferon AnacyFs2s Injection of mice with antibody to interferon renders peritoneal MnA + and Co2+ toxicity in chlorophyll biosynthesis, 476 macrophages permissive for vesicular stomatitis virus and Anaerobic bacteria encephalomyocarditis virus, 602 Plasmid transfer from Escherichia coli to Bacteroides fragifis: Differential Anti-mRNA expression of antibiotic resistance phenotypes, 7203 Anti-mRNA: Specific inhibition of translation of single mRNA Anaerobiosis molecules, 7525 Induction of glucose-regulated proteins during anaerobic exposure and of Anti-pneumococcal serum heat-shock proteins after reoxygenhtion, 4843 Cross-reactions of polysaccharides of fungi, molds, and yeasts in anti- Oxygen regulation of anaerobic and aerobic genes mediated by a common pneumococcal and other antisera, 5247 factor in yeast, 6129 Anti-receptor antibody Analgesia Analysis of the insulin receptor by anti-receptor antibodies and flow O-Endorphin-(1-27) is an antagonist of 3-endorphin analgesia, 1389 cytometry, 7446 O-Endorphin-induced analgesia is inhibited by synthetic analogs of j3 Attachment of an anti-receptor antibody to non-target cells renders them endorphin, 3074 susceptible to lysis by a clone of cytotoxic T lymphocytes, 7922 Inhibition of spontaneous and opiate-modified nociception by an Antiandrogen endogenou§ neuropeptide with Phe-Met-Arg-Phe-NH2-like Simultaneous administration of pure antiandrogens, a combination immunoreactivity, 5002 necessary for the use of luteinizing hormone-releasing hormone Anchorage-independent growth agonists in the treatment of prostate cancer, 3861 Early origin and pervasiveness of cellular heterogeneity in some Antibiotic resistance malignant transformations, 5121 Plasmid transfer from Escherichia coli to Bacteroides fragilis: Differential Androgen expression of antibiotic resistance phenotypes, 7203 Androgen induction of mRNA in mouse kidney Antibody as studied by complementary DNA, 731 See also Monoclonal antibody Androstenone Generation of antibody activity from immunoglobulin polypeptide chains Ability to smell androstenone is genetically determined, 4899 produced in Escherichia coli, 3273 Anesthetic Antibodies of the secondary response can be expressed without switch Halothane shortens acetylcholine receptor channel kinetics without recombination in normal mouse B cells, 7189 affecting conductance, 2929 Antibody, chimeric Angiosperm Chimeric human antibody molecules: Mouse antigen-binding domains Extensive and widespread homologies between mitochondrial DNA and with human constant region domains, 6851 chloroplast DNA in plants, 1946 Antibody clearance Angiotensin Second antibody clearance of radiolabeled antibody in cancer Autoradiographic localization of angiotensin II receptors in rat radioimmunodetection, 2843 brain, 1575 Antibody, cytotoxic Isolation of an angiotensin II-binding protein from liver, 1679 Remission of leukemia and loss of feline leukemia virus in cats injected Angiotensin-converting enzyme with Staphylococcus protein A: Association with increased circulating Autoradiographic visualization of angiotensin-converting enzyme in rat interferon and complement-dependent cytotoxic antibody, 6471 brain with [3H]captopril: Localization to a striatonigral pathway, 1599 Antibody diversity Angiotensin II K gene diversity among the clonal progeny of pre-B lymphocytes, 1529 Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis Generation of antibody diversity in the immune response of BALB/c mice and phosphoinositide hydrolysis and mobilizes intracellular calcium in to influenza virus hemagglutinin, 3180 cultured arterial muscle cells, 7812 Antibody screening Anglerfish Differential antibody screening of cloned Plasmodium falciparum Characterization of a somatostatin-28 containing the (Tyr-7, Gly-10) sequences expressed in Escherichia coli: Procedure for isolation of derivative of somatostatin-14: A terminal active product of defined antigens and analysis of human antisera, 2456 prosomatostatin II processing in anglirfish pancreatic islets, 7003 Cloning of terminal cDNA by antibody screening, 5836 Anion transport Antibody secretion Localization of senescent cell antigen on band 3, 5753 Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte Arsogamy activation, 5537 Search, encounter rates, and the evolution of anisogamy, 6078 Antibody specificity Anisomycin Use of peptide synthesis to probe viral antigens for epitopes to a Requirement for protein synthesis in the regulation of a circadian rhythm resolution of a single amino acid, 3998 by serotonin, 7637 Antibody structure Ankyrin Diversity at the variable-joining region boundary of X light chains has a Goblin (ankyrin) in striated muscle: Identification of the potential pronounced effect on immunoglobulin ligand-binding activity, 6139 membrane receptor for erythroid spectrin in muscle cells, 3292 Anticarcinogen A structural model of human erythrocyte band 2.1: Alignment of chemical Carotenoids and retinol: Their possible importance in determining and functional domains, 4095 longevity of primate species, 7627 Anococcygeus muscle Anticoagulant Neuropeptide-induced contraction and relaxation of the mouse Evaluation of critical groups required for the binding of heparin to anococcygeus muscle, 625 antithrombin, 1030 Anosmia Antigen Ability to smell androstenone is genetically determined, 4899 Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte Anoxia activation, 5537 Induction of glucose-regulated proteins during anaerobic exposure and of Antigen-antibody complex heat-shock proteins after reoxygenation, 4843 Selective killing of Fc-receptor-bearing tumor cells through endocytosis Antamnde of a drug-carrying immune complex, 1445 Identity of hepatic membrane transport systems for bile salts, phalloidin, Antigen F4/80 and antamanide by photoaffinity labeling, 5232 The mononuclear phagocyte system of the mouse defined by Antarctic bacteria immunohistochemical localization of antigen F4/80: Macrophages of Heat-labile alkaline phosphatase from Antarctic bacteria: Rapid 5' end- endocrine organs, 4174 labeling of nucleic acids, 6691 Biological Sciences Subject Index Proc. NatL. Acad. Sci USA 81 (1984) 8047 Antigen internal image Aplysia Human anti-idiotype antibodies in cancer patients: Is the modulation of Branch-specific facilitation in Aplysia siphon sensory the immune response beneficial for the patient?, 216 cells, 2577 helerosynaptic Antigen presentation Evidence for parallel actions of a molluscan neuropeptide and serotonin Antigen conformation determines processing requirements for T-cell in mediating arousal in Aplysia, 2934 activation, 6831 Synaptic stimulation alters protein phosphorylation in vivo in a single Regulation of T-cell function by antibodies: Enhancement of the response Aplysia neuron, 3233 of human T-cell clones to hepatitis B surface antigen by antigen- Functional history of two motor neurons and the morphometry of their specific monoclonal antibodies, 6846 neuromuscular junctions in the gill of Aplysia: Evidence for differential Antigen presentation by murine and human cells to a murine T-cell aging, 4232 hybridoma: Demonstration of a restriction element associated with a A cDNA clone encoding neuropeptides isolated from Aplysia neuron major histocompatibility complex class II determinant(s) shared by Lii, 4988 both species, 7559 Requirement for protein synthesis in the regulation of a circadian rhythm Antigen presentation by supported planar membranes containing affinity- by serotonin, 7637 purified I-A', 7564 Serotonin increases intracellular Ca2' transients in voltage-clamped Immunization in vitro and production of monoclonal antibodies specific to sensory neurons of Aplysia californica, 7642 insoluble and weakly immunogenic proteins, 7897 Two endogenous neuropeptides modulate the gill and siphon withdrawal Antigen processing reflex in Aplysia by presynaptic facilitation involving cAMP-dependent Allogeneic stimulation of cytotoxic T cells by supported planar closure of a serotonin-sensitive potassium channel, 7956 membranes, 6159 Apolipoprotein Antigen recognition Nucleotide sequence and the encoded amino acids of human Pulse labering of small nuclear ribonucleoproteins in vivo reveals distinct apolipoprotein A-I mRNA, 66 patterns of antigen recognition by human autoimmune antibodies, 3185 Localization of the structural gene for human apolipoprotein A-I on the Purification and NH2-terminal amino acid sequencing of the A3 subunit of long arm of human 11, 508 a human T-cell antigen receptor, 3851 Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I, 1356 Antigen, viral Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich Simultaneous in situ detection of viral RNA and antigens, 5445 lipoproteins in normal and -deficient , 1839 Antigenic determinant Assignment of the human gene for the low density lipoprotein receptor to Biologically active synthetic fragments of epidermal growth factor: chromosome 19: Synteny of a receptor, a ligand, and a genetic Localization of a major receptor-binding region, 1351 disease, 2826 Method to map antigenic determinants recognized by monoclonal Isolation and sequence of a human apolipoprotein CII cDNA clone and antibodies: Localization of a determinant of virus neutralization of the its use to isolate and map to human chromosome 19 the gene for feline leukemia virus envelope protein gp7O, 3675 apolipoprotein CII, 2945 Antigenic stimulation Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino Antigenic stimulation regulates the level of expression of interleukin 2 acid segment with amphipathic helical potential, 5021 receptor on human T sells, 2172 Role of apolipoprotein E in the lipolytic conversion of 83-very low density Antigenic variation lipoproteins to low density lipoproteins in type III Variant antigen genes of Trypanosoma brucei: Genomic alteration of a hyperlipoproteinemia, 5566 spliced leader orphon and retention of expression-linked copies during Liver uptake of chylomicron remnants with high and low apoprotein E:C differentiation, 684 ratios, 5863 Trypanosome variant-specific glycoproteins: A polygene Human apolipoprotein C-II: Complete nucleic acid sequence of with multiple folding patterns?, 998 preapolipoprotein C-II, 6354 Variant antigen genes of Trypanosoma brucei: Genomic alteration of a Apple spliced leader orphon and retention of expression-linked copies during Calmodulin inhibitor in senescing apples and its physiological and differentiation (Correction), 2944 pharmacological significance, 2065 Characterization of the genes specifying two metacyclic variable antigen types in Trypanosoma brucei rhodesiense, 6642 Defining erythrocyte internal labeling by phosphorylation, 2767 Antigenicity Apyrimidinic site A side chain on hemagglutinins of Hong Kong influenza Hydroxymethyluracil DNA in mammalian cells, 4003 viruses inhibits recognition by a monoclonal antibody, 1779 L-Arabinose Antigua Regulation of the araC gene of Escherichia coli: Catabolite repression, Fossil vertebrates from Antigua, Lesser Antilles: Evidence for late autoregulation, and effect of a'aBAD expression, 4120 Holocene human-caused extinctions in the West Indies, 4448 Arachidonic acid- Antiport Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 Mechanisms of glycosylation and sulfation in the Golgi apparatus: synthesis from arachidonic acid, 689 Evidence for nucleotide sugar/ monophosphate and 12S,20-Dihydroxyicosatetraenoic acid: A new icosanoid synthesized by nucleotide sulfate/nucleoside monophosphate antiports in the Golgi neutrophils from 12S-hydroxyicosatetraenoic acid produced by apparatus membrane, 7051 thrombin- or collagen-stimulated platelets, 903 Antipsychotic drug Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor u opiates and qertain antipsychotic drugs mutually inhibit (+)-[3H]SKF BW755C, 2890 10,047 and [ H]haloperidol binding in guinea pig brain membranes, 5618 Neurotransmitter receptors mediate cyclic GMP formation by Antithrombin involvement of arachidonic acid and lipoxygenase, 3905 Antithrombin III Toyama: Replacement of arginine-47 by cysteine in Lipoxins: Novel series of biologically active compounds formed from hereditary abnormal antithrombin III that lacks heparin-binding arachidonic acid in human leukocytes, 5335 ability, 289 Leukofriqnes in the rat central nervous system, 6212 Evaluation of critical groups required for the binding of heparin to Arachnida antithrombin, 1030 Spider venoms inhibit L-glutamate binding to brain synaptic membrane a,-Antitrypsin receptors, 5571 High-level production of biologically active human a1-antitrypsin in Araneus Escherichia coli, 669 Spider venoms inhibit L-glutamate binding to brain synaptic membrane Monoclonal antibody specific for the mutant PiZ a,-antitrypsin and its receptors, 5571 application in an ELISA procedure for identification of PiZ gene Archaebacteria carriers, 5690 Major h.at shock gene of Drosophila and the Escherichia coli heat- Expression of a human a1-antitrypsin cDNA in the yeast Saccharomyces inducible dnaK gene are homologous, 848 cerevisiae, 6594 An immune strain of Halobacterium halobium carries the invertible L Antitumor drug segment of phage 4H as a plasmid,' 1017 Mechanism of antitumor drug action: Poisoning of mammalian DNA Arg-Lys esteropeptidase topoisomerase II on DNA by 4'-(9-acridinylamino)methanesulfon-m- Enzymes processing somatostatin precursors: An Arg-Lys anisidide, 1361 esteropeptidase from the rat brain cortex converting somatostatin-28 Antiviral activity into somatostatin-14, 6662 Pleiotropic activities of human interferons are mediated by multiple Argie response pathways, 170 DNA sequence of the carA gene and the control region of carAB: Antiviral compound Tandem promoters, respectively controlled by arginine and the DNA and RNA virus species are inhibited by xanthates, a class of , regulate the synthesis of carbamoyl-phosphate synthetase antiviral compounds with unique properties, 3263 in Escherichia coliK-12, 4134 Aorta Multiple regulatory signals in the control region of the Escherichia coli Specific membrane receptors for atrial natriuretic factor in renal and carAB operon, 4139 vascular tissues, 5946 Argininosuccinate Iyase Apamin Interallelic complementation in an inborn error of metabolism: Genetic The presence of pig brain of an endogenous equivalent of apamin, the bee heterogeneity in argininosuccinate deficiency, 4480 venom peptide that specifically blocks Ca2'-dependent Ki Arotinoid Ro 13-6298 channels, 7228 Cloning of cDNAs specifying vitamin A-responsive human keratins, 4321 Aphidicolin Arousal Kinetics of thymidine incorporation into detergent-soluble DNA of mouse Evidence for parallel actions of a molluscan neuropeptide and serotonin lymphocytes, 70Z6 in mediating arousal in Aplysia, 2934 8048 Biological Sciences Subject Index Proc. Nadl. Acad Sci. USA 81 (1984)

Arteriogenesis Monomeric solubilized sarcoplasmic reticulum Ca pump protein: Direct arterial vascularization of estrogen-induced prolactin-secreting Demonstration of Ca binding and dissociation coupled to ATP anterior pituitary tumors, 4549 hydrolysis, 6623 Arthritis Is ATP a central synaptic mediator for certain primary afferent fibers Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: from mammalian skin?, 6890 Selectivity among HLA-DR5 haplotypes, 3539 ATP-bndsite Artifact ATP-binding sites in the membrane components of the histidine Artifacts caused by cell microinjection, 1426 permease, a periplasmic transport system, 7333 6-Arylamino-5-oxo(3H,5H) ATP synthase The possibility that the spectrum of intermediate two, seen in the course Cooperative transient trapping of photosystem II protons by the integral of reaction of flavoenzyme phenol hydroxylases, may be attributable to membrane portion (CFO) of chloroplast ATP-synthase after mild iminol isomers of a flavin-derived 6-arylamino-5-oxo(3H,5H)uracil, 332 extraction of the four-subunit catalytic part (CF1), 3078 Arylation Subunit b of the membrane moiety (Fo) of ATP synthase (F1F0) from Regioselective arylation of ribose in adenosine and guanosine with the Escherichia coli is indispensable for H' translocation and binding of antitumor drug N2-methyl-9-hydroxyellipticinium acetate, 1297 the water-soluble F. moiety, 7279 Ascorbic acid AT1ase Interaction of the 2,6-dimethoxysemiquinone and ascorbyl free radicals Ca2+-ATPase of the sarcoplasmic reticulum shares a common domain with Ehrlich ascites cells: A probe of cell-surface charge, 2088 with a membrane glycoprotein associated with the of 31p NMR study of improvement in oxidative phosphorylation by vitamins microvilli, 1130 K3 and C in a patient with a defect in electron transport at complex III Two different Na,K- in the optic nerve: Cells of origin and in skeletal muscle, 3529 axonal transport, 1234 Asialoglycoprotein Evidence for the involvement of coupling factor B in the H' channel of Two populations of prelysosomal structures transporting the mitochondrial H+-ATPase, 1371 asialoglycoproteins in rat liver, 2995 Molecular cloning of the mouse ouabain-resistance gene, 1489 Asialoglycoprotein receptor Partial deglycosylation of chloroplast coupling factor 1 (CF1) prevents the Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal reconstitution of photophosphorylation, 3733 signal sequence, 7338 Intracellular targeting and import of an Fj-ATPase P-subunit-13- galactosidase hybrid protein into yeast mitochondria, 3983 D-Aspartate Mammalian Mammalian brain and erythrocyte carboxyl methyltransferases are similar DNA polymerase a holoenzymes with possible functions at enzymes that recognize both D-aspartyl and L-isoaspartyl the leading and lagging strand of the replication fork, 3993 residues in between two membrane transport ATPases, the Kdp- structurally altered protein substrates, 7757 ATPase of Escherichia coli and the Ca2+-ATPase of sarcoplasmic Aspartate carbamoyltransferase reticulum, 4746 Structure of unligated aspartate carbamoyltransferase of Escherichia coli Na+ movement in a single turnover of the Na pump, 5310 at 2.6-A resolution, 4037 Isolated rat hepatocyte couplets: A primary secretory unit for Aspartate transcarbamoylase electrophysiologic studies of bile secretory function, 6516 Location of amino acid alterations in mutants of aspartate Monomeric solubilized sarcoplasmic reticulum Ca pump protein: transcarbamoylase: Structural aspects of interallelic Demonstration of Ca binding and dissociation coupled to ATP complementation, 115 hydrolysis, 6623 Protein differentiation: A comparison of aspartate transcarbamoylase and Subunit b of the membrane moiety (FO) of ATP synthase (FIFO) from ornithine transcarbamoylase from Escherichia coli K-12, 4864 Escherichia coli is indispensable for H+ translocation and binding of Aspartic add phosphorylation the water-soluble F1 moiety, 7279 Sequence homology between two membrane transport ATPases, the Kdp- Atrazine ATPase of Escherichia coli and the Ca +-ATPase of sarcoplasmic Membrane protein damage and repair: Selective loss of a quinone-protein reticulum, 4746 function in chloroplast membranes, 4070 Aspartic protease Triazine herbicide resistance in the photosynthetic bacterium Synthesis of peptides related to the prosegment of mouse submaxillary Rhodopseudomonas sphaeroides, 6310 gland renin precursor: An approach to renin inhibitors, 48 Atrial natriuretic factor Amino acid sequence of porcine spleen cathepsin D, 3703 Amino acid sequence of homologous rat atrial peptides: Natriuretic Human renin gene: Structure and sequence analysis, 5026 activity of native and synthetic forms, 2640 Structure of the human renin gene, 5999 Specific membrane receptors for atrial natriuretic factor in renal and Aspartokinase vascular tissues, 5946 Internal homologies in the two aspartokinase-homoserine Molecular cloning and characterization of DNA sequences encoding rat dehydrogenases of Escherichia coli K-12, 3019 and human atrial natriuretic factors, 6325 Aspergillus Atrial natriuretic factor elicits an endothelium-independent relaxation and Transformation of Aspergillus nidulans by using a trpC plasmid, 1470 activates particulate guanylate cyclase in vascular smooth muscle, 7661 Immunosuppression in vitro by a metabolite of a human pathogenic Atrial pronatriodilatin fungus, 3835 Molecular cloning and characterization of DNA sequences encoding rat Asthma and human atrial natriuretic factors, 6325 Leukotriene E4-induced airway hyperresponsiveness of guinea pig Attenuation tracheal smooth muscle to histamine and evidence for three separate Attenuation of the ilvB operon by amino acids reflecting substrates or sulfidopeptide leukotriene receptors, 4922 products of the ilvB gene product, 76 AT Detecting protein-DNA interactions in vivo: Distribution of RNA Yeast mitochondrial genomes consisting of only AT base pairs replicate polymerase on specific bacterial genes, 4275 and exhibit suppressiveness, 7156 AUG Atherogenesis Affecting gene expression by altering the length and sequence of the 5' Human endothelial cells in culture produce platelet-activating factor leader, 7698 (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with Ausab assay thrombin, 3534 Hepatitis B surface antigen and polymerized albumin binding activity in Atherosclerosis sheep serum, 564 Specific covalent binding of platelet-derived growth factor to human Autoantibody plasma a2-macroglobulin, 342 The Ro small cytoplasmic ribonucleoproteins: Identification of the Localization of the structural gene for human apolipoprotein A-I on the antigenic protein and its binding site on the Ro , 1996 long arm of human chromosome 11, 508 Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM Aminomalonic acid: Identification in Escherichia coli and atherosclerotic autoantibodies, 2494 plaque, 722 Human autoantibodies against desmosomes: Possible causative factors in Specific covalent binding of platelet-derived growth factor to human pemphigus, 2781 plasma a2-macroglobulin (Correction), 2586 Autoantibodies to glucosylated proteins in the plasma of patients with Modification of low density lipoprotein by endothelial cells involves lipid diabetes, 3204 peroxidation and degradation of low density lipoprotein Somatic mutation of the T15 heavy chain gives rise to an antibody with phospholipids, 3883 autoantibody specificity, 5841 Structure of the cholesteryl ester core of human plasma low density Autocrine lipoproteins: Selective deuteration and neutron small-angle Neuroblastoma cells produce transforming growth factors during scattering, 4389 exponential growth in a defined hormone-free medium, 4085 5a-Cholest-8(14)-en-3,-ol-15-one lowers serum cholesterol and induces Autocrine stimulation profound changes in the levels of lipoprotein cholesterol and Blockade of autocrine stimulation in simian sarcoma virus-transformed apoproteins in monkeys fed a diet of moderate cholesterol cells reverses down-regulation of platelet-derived growth factor content, 6861 receptors, 7466 ATP Autodigestion ATP-dependent degradation of ubiquitin-protein conjugates, 1619 Autodigestion of lexA and phage X repressors, 1375 ATP-dependent asymmetric distribution of spin-labeled phospholipids in Autoimmune antibody the erythrocyte membrane: Relation to shape changes, 3751 Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct Catalytic consequences of oligomeric organization: Kinetic evidence for of "tethered" acto-heavy meromyosin at low ATP concentrations, 5345 patterns antigen recognition by human autoimmune antibodies, 3185 Adenosine release from stimulated mast cells, 6192 Autoimmune diseas In vivo metabolic effects of hyperglycemia in murine radiation-induced Human autoantibodies against desmosomes: Possible causative factors in fibrosarcoma: A 31P NMR investigation, 6496 pemphigus, 2781 Acetylcholine receptor-specific suppressive T-cell factor from a retrovirally transformed T-cell line, 7569 Biological Sciences Subject Index Proc. NatL Acad Scd USA 81 (1984) 8049

Autoimmunity The persistence of maternal inheritance in Chlamydomonas despite Goodpasture antigen of the glomerular basement membrane: Localization hypomethylation of chloroplast DNA induced by inhibitors, 3438 to noncollagenous regions of type IV collagen, 3838 Activation of a chicken embryonic globin gene in adult erythroid cells by A monoclonal anti-DNA antibody also binds to cell-surface 5-azacytidine and sodium butyrate, 3954 protein(s), 3843 DNA methylation and regulation of the human 6-globin-like genes in Influence of early or late dietary restriction on life span and mouse erythroleukemia cells containing human chromosome 11, 6618 immunological parameters in MRL/Mp-lpr/lpr mice, 5831 5-Azacytosine Novel B-cell maturation factor from spontaneously autoimmune viable Covalent bond formation between a DNA- methyltransferase and motheaten mice, 7199 DNA containin 5-azacytosine, 6993 Autoradiography N-[4-(p-Azido-m-[1 Ilodophenylazo)benzoylJ-3-aminopropyl-N'- Quantitative autoradiography of 81- and j2-adrenergic receptors in rat oxssulfosuccinimide ester brain, 1585 12 I-labeled crosslinking reagent that is hydrophilic, photoactivatable, and Visualization of opiate receptor upregulation by light microscopy cleavable through an azo linkage, 5286 autoradiography, 3893 8-Azidoadenine Autoregulation Photoaffinity labeling and characterization of the cloned purine-cytosine Regulation of the araC gene of Escherichia coli: Catabolite repression, transport system in Saccharomyces cerevisiae, 6276 autoregulation, and effect of araBAD expression, 4120 Azo linkage Autosome I25I-labeled crosslinking reagent that is hydrophilic, photoactivatable, and Characterization of a cloned DNA sequence that is present at cleavable through an azo linkage, 5286 centromeres of all human autosomes and the X chromosome and shows p-Azophenylarsonate polymorphic variation, 4884 Expression and rearrangement of homologous immunoglobulin VH genes Autotrophic pathway in two mouse strains, 2167 Role of carbon monoxide dehydrogenase in the autotrophic pathway used Azotobacter by acetogenic bacteria, 6261 H2-uptake activity of the MoFe protein component of Azotobacter Auxin vinelandii nitrogenase, 376 Indole-3-acetic acid sensitization of phytochrome-controlled growth of Spectroscopic studies of ferricyanide oxidation of Azotobacter vinelandii coleoptile sections, 3742 ferredoxin I, 1931 Avena Molecular cloning of cDNA for Avena phytochrome, 2332 Indole-3-acetic acid sensitization of phytochrome-controlled growth of B cell coleoptile sections, 3742 See also B lymphocyte Avian carcinoma virus MH2 K gene diversity among the clonal progeny of pre-B lymphocytes, 1529 Nucleotide sequence of avian carcinoma virus MH2: Two potential onc Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM genes, one related to avian virus MC29 and the other related to murine autoantibodies, 2494 sarcoma virus 3611, 3000 Disappearance and reappearance of B cells after in vivo treatment with Avian erythroblastosis virus monoclonal anti-I-A antibodies, 2855 Cellular homologs of the avian erythroblastosis virus erb-A and erb-B The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) genes are syntenic in mouse but asyntenic in man, 4874 translocation involves the immunoglobulin heavy chain locus, 4144 Avian leukosis virus Increased expression of Ia antigens on resting B cells: An additional role Proviral deletions and oncogene base-substitutions in insertionally for B-cell growth factor, 6149 mutagenized c-myc alleles may contribute to the progression of avian Antibodies of the secondary response can be expressed without switch bursal tumors, 843 recombination in normal mouse B cells, 7189 Nucleotide sequence 5' of the chicken c-myc coding region: Localization Retrovirus-induced expression of interleukin 2 receptors on cells of of a noncoding exon that is absent from myc transcripts in most avian human B-cell lineage, 7441 leukosis virus-induced lymphomas, 4697 Human interleukin 2 can promote the growth factor and differentiation of Nucleotide sequence 5' of the chicken c-myc coding region: Localization single hapten-specific B cells in the presence of specific antigen, 7917 of a noncoding exon that is absent from myc transcripts in most avian B-cell activation leukosis virus-induced lymphomas (Correction), 7258 Single-cell studies on hapten-specific B cells: Response to T-cell- Avian myeloblastosis virus dependent antigens, 2479 Avian myeloblastosis virus and E26 virus oncogene products are nuclear B-cell differentiation factor proteins, 4265 Development of a human T-cell hybridoma secreting separate B-cell Aberrant expression of an amplified c- oncogene in two cell lines growth differentiation factors, 2475 from a colon carcinoma, 4534 B-cael growth factor Avian sarcoma virus Development of a human T-cell hybridoma secreting separate B-cell Avian sarcoma virus gag and env gene structural protein precursors growth differentiation factors, 2475 contain a common amino-terminal sequence, 362 Increased expression of Ia antigens on resting B cells: An additional role src- andfps-containing avian sarcoma viruses transform chicken erythroid for B-cell growth factor, 6149 cells, 7122 Evidence for an intracellular precursor for human B-cell growth Avian tumor virus MC29 factor, 7902 Nucleotide sequence of avian carcinoma virus MH2: Two potential onc B-cell leukemia genes, one related to avian virus MC29 and the other related to murine A 14;18 and an 8;14 chromosome translocation in a cell line derived from sarcoma virus 3611, 3000 an acute B-cell leukemia, 7166 Avicennia B-cell lymphoma NMR study of chloride ion interactions with thylakoid membranes, 3713 Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell Avidin-biotin lymphoma, 593 Detection of non-A, non-B hepatitis antigen by immunocytochemical Transformation-associated proteins in murine B-cell lymphomas that are staining, 3195 distinct from Abelson virus gene products, 4434 Avidin-biotin affinity chromatography Specific regulation of c-myc oncogene expression in a murine B-cell Avidin-biotin affinity chromatography: Application to the isolation of lymphoma, 5546 human placental insulin receptor, 7328 B-cell maturation factor Axon Novel B-cell maturation factor from spontaneously autoimmune viable Developing dorsal root ganglion neurons require trophic support from motheaten mice, 7199 their central processes: Evidence for a role of retrogradely transported B-DNA nerve growth factor from the central nervous system to the Model of specific complex between catabolite gene activator protein and periphery, 6245 B-DNA suggested by electrostatic complementarity, 3973 Axon guidance B lymphocyte Fiber-fiber interaction and tectal cues influence the development of the See also B cell chicken retinotectal projection, 1906 Identification of a 145,000 Mr membrane protein as the C3d receptor Axon terminal (CR2) of human B lymphocytes, 881 y-Aminobutyric acid acts at axon terminals of turtle photoreceptors: Induction of y-interferon activity by elevated temperatures in human B- Difference in sensitivity among cell types, 7961 lymphoblastoid cell lines, 4033 Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor Axonal regeneration CR2, 4510 Peptides from the regenerating central nervous system of goldfish Internal complementarities in the immune system: Regulation of the stimulate glia, 3567 expression of helper T-cell idiotypes, 4520 Axonal transport Infection of B lymphocytes by a human herpesvirus, Epstein-Barr virus, Two different Na,K-ATPases in the optic nerve: Cells of origin and is blocked by calmodulin antagonists, 4955 axonal transport, 1234 Antigen-specific helper T-cell clone supernatant is sufficient to induce Axonal transport of a subclass of r proteins: Evidence for the regional both polyclonal proliferation and differentiation of small resting B differentiation of microtubules in neurons, 1570 lymphocytes, 6491 In vitro evidence that covalent crosslinking of neurofilaments occurs in y- Long-term cultured B lymphocytes and their precursors reconstitute the diketone neuropathy, 4979 B-lymphocyte lineage in vivo, 7554 5-Azacytidine Induction of the metastatic phenotype in a mouse tumor model by B-lymphocyte activation 5-azacytidine, and characterization of an antigen associated with Role of cell surface immunoglobulin in B-lymphocyte activation, 2466 metastatic activity, 3389 Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte Growth hormone promotes the differentiation of myoblasts and activation, 5537 preadipocytes generated by azacytidine treatment of 10TI/2 cells, 3429 8050 Biological Sciences Subject Index Proc. Natl. Acad. Sci USA 81 (1984)

B protein Bacteriophage A repressor Nucleotide sequence of a multiple-copy gene for the B protein of Effect of single amino acid replacements on the thermal stability of the photosystem II of a cyanobacterium, 2693 NH2-terminal domain of phage A repressor, 5685 Baboon Bacteriophage M13 Schistosoma mansoni egg granuloma size reduction in challenged Mutational specificity of depurination, 1494 baboons after vaccination with irradiated cryopreserved Rapid mutational analysis of regulatory loci in Escherichia coli K-12 using schistosomula, 3552 bacteriophage M13, 3801 Baccatine Bacteriophage Mu Relationships between the structures of taxol and baccatine III In vivo formation of gene fusions encoding hybrid 6-galactosidase derivatives and their in vitro action on the disassembly of mammalian proteins in one step with a transposable Mu-lac transducing phage, 535 brain and Physarum amoebal microtubules, 4090 In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac Bacilus bacteriophage containing a plasmid replicon, 1480 Use of the Escherichia coli lac repressor and operator to control gene A genetic switch in vitro: DNA inversion by Gin protein of phage expression in Bacillus subtilis, 439 Mu, 2689 The subtilisin E gene of Bacillus subtilis is transcribed from a a- Bacteriophage P1 promoter in vivo, 1184 Interaction of the bacteriophage P1 recombinase Cre with the Purification in a functional form of the terminal protein of Bacillus recombining site loxP, 1026 subtilis phage 429, 1639 Plasmid P1 replication: Negative control by repeated DNA Selective expression of a plasmid cat gene at a late stage of Bacillus sequences, 6456 subtilis sporulation, 3457 Bacteriophage P2 Twisted states of Bacillus subtilis macrofibers reflect structural states of DNA sequences of the repressor gene and operator region of the cell wall, 3562 bacteriophage P2, 3988 Generation of deletions in pneumococcal mal genes cloned in Bacillus Bacteriopae P22 subtilis, 5189 Single ammo acid substitutions influencing the folding pathway of the Characterization of the Bacillus subtilis tryptophan promoter region, 6315 phage P22 tail spike endorhamnosidase, 6584 Nucleotide sequence of the spoOB gene of Bacillus subtilis and regulation Bacteriophage Pf3 of its expression, 7012 Major coat protein and single-stranded DNA-binding protein of The 64-kilodalton membrane protein of Bacillus subtilis is also present as filamentous virus 699 a multiprotein complex on Pf3, membrane-free ribosomes, 7772 Bacteriophage #29 Bacterial behavior Template requirements for initiation of phage 429 DNA replication in The role of a signaling protein in bacterial sensing: Behavioral effects of vitro, 80 increased gene expression, 5056 Purification in a functional form of the terminal protein of Bacillus Bacterial transport subtilis phage 429, 1639 Portage of various compounds into bacteria by attachment to glycine Characterization and purification of a phage 029-encoded DNA residues in peptides, 4573 polymerase required for the initiation of replication, 5325 Bacteriochlorophyll Replication of bacteriophage 429 DNA replication in vitro: The roles of Structural studies of the primary donor cation radical P8 in reaction terminal protein and DNA polymerase, 5374 centers of Rhodospirillum rubrum by electron-nuclear double Bacteriophage OH resonance in solution, 1401 An immune strain of Halobacterium halobium carries the invertible L N electron nuclear double resonance of the primary donor cation radical segment of phage OH as a plasmid, 1017 P+ in reaction centers of Rhodopseudomonas sphaeroides: Additional Bacteriophage 6X174 evidence for the dimer model, 7792 Enzymatic techniques for the isolation of random single-base Bacteriodes substitutions in vitro at high frequency, 2030 Plasmid transfer from Escherichia coli to Bacteroides fragilis: Differential Cleavage of single-stranded DNA by the 4X174 A* protein: The A*- expression of antibiotic resistance phenotypes, 7203 single-stranded DNA covalent linkage, 4285 Bacterio-opsin Enzymatic techniques for the isolation of random single-base Bacterio-opsin mRNA in wild-type and bacterio-opsin-deficient substitutions in vitro at high frequency (Correction), 4599 Halobacterium halobium strains, 125 Bacteriophage SP0l Specific amino acid substitutions in bacterioopsin: Replacement of a Sequence of the bacteriophage SP01 gene coding for transcription factor restriction fragment in the structural gene by synthetic DNA fragments 1, a viral homologue of the bacterial type II DNA-binding containing altered codons, 2285 proteins, 7031 Bacteriophage 434 Bacteriophage SK6 Cocrystals of the DNA-binding domain of phage 434 repressor and a In vitro-synthesized adenovirus 2 messenger RNA precursors are synthetic phage 434 operator, 1307 accurately spliced by nuclear extracts, 4707 Bacteriophage fn Bacteriophage T3 Increased intracellular concentration of an initiator protein markedly Virus-plasmid interactions: Mutants of bacteriophage T3 that abortively reduces the minimal sequence required for initiation of DNA infect plasmid F-containing (F+) strains of Escherichia coli, 1465 synthesis, 1336 Bacteriophage T4 Enzymatic techniques for the isolation of random single-base Intervening sequence in the thymidylate synthase gene of bacteriophage substitutions in vitro at high frequency, 2030 T4, 3049 Enzymatic techniques for the isolation of random single-base Defining a bacteriophage T4 late promoter: Bacteriophage T4 gene 55 substitutions in vitro at high frequency (Correction), 4599 protein suffices for directing late promoter recognition, 5101 Bacteriophage A Demonstration of the production of frameshift and base-substitution Twodimensional 'H NMR study of the A operator site OLJ: A sequential by quasipalindromic DNA sequences, 5528 assignment strategy and its application, 130 Bacteriophage 17 Mutational analysis of a regulatory region in bacteriophage A that has Virus-plasmid interactions: Mutants of bacteriophage T3 that abortively overlapping signals for the initiation of transcription and infect plasmid F-containing (F+) strains of Escherichia coli, 1465 translation, 555 Cloning and expression of the gene for bacteriophage T7 RNA Autodigestion of lexA and phage A repressors, 1375 polymerase, 2035 The rnh gene is essential for growth of Escherichia coli, 3447 Identification and characterization of a new transcriptional termination Formation of termination-resistant transcription complex at phage A nut factor from Escherichia coli, 7373 locus: Effects of altered translation and a ribosomal mutation, 3612 Bacterlorhodopsin Effect of single amino acid replacements on the thermal stability of the mRNA in and NH2-terminal domain of phage A repressor, 5685 Bacterio-opsin wild-type bacterio-opsin-deficient In vitro regulation of phage A cII gene expression by Escherichia coli Halobacterium halobium strains, 125 integration host factor, Dark-adapted bacteriorhodopsin contains 13-cis,15-syn and all-trans,15- 6009 anti retinal Schiff bases, 1706 Dynamic filtering by two-dimensional 1H NMR with application to phage Determination of retinal Schiff base configuration in A repressor, 6019 bacteriorhodopsin, 2055 Extention of bacteriophage A host range: Selection, cloning, and Retinal dark characterization of a constitutive A receptor gene, 6080 migration during reduction of bacteriorhodopsin, 2303 nusB: A protein factor necessary for transcription antitermination in vitro A correlation between proton pumping and the bacteriorhodopsin by phage A N gene product, 6305 photocycle, 7079 Kinetic analysis of mutations affecting the cIl activation site at the PRE On the protein (tyrosine)-chromophore (protonated Schiff base) coupling promoter of bacteriophage A, 6432 in bacteriorhodopsin, 7083 Evidence for inclusion of regions of nonhomology in heteroduplex Balbian ring products of bacteriophage A recombination, 7180 Balbiani rng induction in phosphate metabolism, 1448 Multiple initiation sites of DNA replication flanking the origin region of Different evolutionary behavior of structurally related, repetitive Adv genome, 7402 sequences occurring in the same Balbiani ring gene in Chironomus Enhanced recombination between AplacS and F421ac: Identification of tentans, 5165 cis- and trans-acting factors, 7500 BamHI restriction Bacteriophage A DNA Restriction can be used to study B-Z junctions in DNA methylation pattern is determined by the intracellular level of the supercoiled DNA, 5714 methylase, 3278 Band 3 Bacteriophage A receptor Localization of senescent cell antigen on band 3, 5753 Amino acid sequence homology among the major outer membrane Barium proteins of Escherichia coli, 1048 Cell swelling increases a barium-inhibitable potassium conductance in the basolateral membrane of Necturus small intestine, 3591 Biological Sciences Subject Index Proc. NatL Acad Sci USA 81 (1984) 8051

Single channel recordings of calcium-activated potassium channels in the Biotin operon apical membraiqe of rabbit cortical collecting tubules, 4237 DNA sequences of the repressor gene and operator region of Facilitation of Ca"k-channel currents in bovine adrenal chromaffin bacteriophage P2, 3988 cells, 5871 Barley NMaB .(6-Biotinylamido)hexanoylinsulin Ribosomal DNA spacer-length polymorphisms in barley: Mendelian Avidin-biotin affinity chromatography: Application to the isolation of inheritance, chromosomal location, and population dynamics, 8014 human placental insulin receptor, 7328 Base sequence specificity Birdsong Nucleic acid-binding molecules with high affinity and base sequence Population differences in complexity of a learned skill are correlated with specificity: Intercalating agents covalently linked to the brain space involved, 6232 oligodeoxynucleotides, 3297 Birefringence Base substitution Evidence for the existence of stable curvature of DNA in solution, 4632 Proviral deletions and oncogene base-substitutions in insertionally 2',7'-Bis(carboxyethyl)-5(6)-carboxyfluorescein mutagenized c-myc alleles may contribute to the progression of avian Na+-H+ exchange in gastric glands as measured with a cytoplasmic- bursal tumors, 843 trapped, fluorescent pH indicator, 7436 Demonstration of the production of frameshift and base-substitution Bis[cyclo(histidylhistidine)]copper(II) complex mutations by quasipalindromic DNA sequences, 5528 Bis[cyclo(histidylhistidine)]copper(II) complex that mimicks the active Basement membrane center of superoxide dismutase has its catalytic activity, 3283 Monoclonal antibodies to human type IV collagen: Useful reagents to Blacks demonstrate the heterotrimeric nature of the molecule, 7343 Origin of the t3S-globin gene in Blacks: The contribution of recurrent Basophil mutation or gene conversion or both, 853 The cromolyn binding protein constitutes the Ca2+ channel of basophils ,3-Thalassemia in American Blacks: Novel mutations in the "TATA" box opening upon immunological stimulus, 6841 and an acceptor splice site, 1154 Bee venom P-Thalassemia in American Blacks: Novel mutations in the "TATA" box The presence of pig brain of an endogenous equivalent of apamin, the bee and an acceptor splice site (Correction), 3605 venom peptide that specifically blocks Ca2+-dependent K+ Bladder cancer channels, 7228 Cell surface antigens of human bladder cancer defined by mouse Behavior monoclonal antibodies, 224 Seasonal aggression independent of seasonal testosterone in wood Blood-brain barrier rats, 5255 Identification and characterization of the glucose transporter of the Group selection for a polygenic behavioral trait: Estimating the degree of blood-brain barrier by cytochalasin B binding and immunological population subdivision, 6073 reactivity, 7233 Two endogenous neuropeptides modulate the gill and siphon withdrawal Blood coagulation reflex in Aplysia by presynaptic facilitation involving cAMP-dependent Regional localization on the human X chromosome and polymorphism of closure of a serotonin-sensitive potassium channel, 7956 the coagulation factor IX gene (hemophilia B locus), 498 Behavioral rhythm Activation of factor IX bound to cultured bovine aortic endothelial Molecular genetics of a biological clock in Drosophila, 2142 cells, 913 Characterization of a cDNA coding for human factor X, 3699 Benzamide Characterization of a cDNA coding for human protein C, 4766 Inhibition of malignant transformation in vitro by inhibitors of poly(ADP- Cloning and sequencing of liver cDNA coding for bovine protein C, 5653 ribose) synthesis, 243 Localization of a fibrin y-chain polymerization site within segment Thr- Benzhydrazone 374 to Glu-3% of human fibrinogen, 5980 Characterization of a herpes simplex virus type 1 mutant resistant to benzhydrazone, a selective inhibitor of herpesvirus glycosylation, 2440 Blood coagulation factor Benzotalpyrene Vaccinia virus 19-kilodalton protein: Relationship to several mammalian Mutagenicity of quinones: Pathways of metabolic activation and proteins, including two growth factors, 7363 detoxification, 16% Blood group Inhibition of DNA synthesis by an electrophilic metabolite of Biochemical evidence that secretor gene, Se, is a structural gene benzo[a]pyrene, 5300 encoding a specific fucosyltransferase, 4193 Polycyclic aromatic hydrocarbon mutagenesis of human epidermal Blood pressure keratinocytes in culture, 7802 Adenosine strongly potentiates pressor responses to nicotine in rats, 5599 Benzolalpyrene diol epoxide Molecular cloning and characterization of DNA sequences encoding rat Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to and human atrial natriuretic factors, 6325 DNA proceed through similar rate-determining steps, 2635 Intracellular free magnesium in erythrocytes of essential hypertension: Site-specific carcinogen binding to DNA, 5623 Relation to blood pressure and serum divalent cations, 6511 Use of short DNA oligonucleotides for determination of DNA sequence Blood substitute modifications induced by benzo[a]pyrene diol epoxide, 5936 Enhanced oxygen unloading by an interdimerically crosslinked Benzodiazepine hemoglobin in an isolated perfused rabbit heart, 2941 Benzodiazepines that bind at peripheral sites inhibit cell proliferation, 753 Bloom syndrome Interaction of calcium channel blockers with non-neuronal Altered temporal expression of DNA repair in hypermutable Bloom's benzodiazepine binding sites, 1549 syndrome cells, 757 Differentiation of Friend erythroleukemia cells induced by Protease inhibitors reduce the frequency of spontaneous chromosome benzodiazepines, 3770 abnormalities in cells from patients with Bloom syndrome, 1827 Body size Benzodiazepine receptor Water flow and coral colony size: Interhabitat comparisons of the Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive octocoral Alcyonium siderium, 5473 calcium channels in nerve terminal preparations, 3118 Body size and fooD size in freshwater zooplankton, 6427 3-(4'-Benzoylphenyl)propionyl[3H]Phe-tRNA Body weight Identification of a site on 23S ribosomal RNA located at the peptidyl Rapid recovery of body mass after surgical removal of adipose tissue in transferase center, 3607 ground squirrels, 2270 Bergmann glia Bohr effect Neuronal influence on glial enzyme expression: Evidence from mutant Structure of deoxyhemoglobin Cowtown [His HC3(146)P-*Leu]: Origin of mouse cerebella, 4414 the alkaline Bohr effect and electrostatic interactions in Bile acid hemoglobin, 4781 Formation of bile acid glucosides by a sugar nucleotide-independent Bombesin glucosyltransferase isolated from human liver microsomes, 7036 A bombesin immunoreactive peptide in milk, 578 Bile canaliculus Bombesin stimulates insulin secretion by a pancreatic islet cell line, 1822 Ca2+ causes active contraction of bile canaliculi: Direct evidence from Cloning and characterization of cDNAs encoding human gastrin-releasing microinjection studies, 6164 peptide, 5699 Isolated rat hepatocyte couplets: A primary secretory unit for Bombyx electrophysiologic studies of bile secretory function, 6516 Natural fibroin genes purified without using cloning procedures from Bile salt fibroin-producing and -nonproducing tissues reveal indistinguishable Identity of hepatic membrane transport systems for bile salts, phalloidin, structure and function, 1644 and antamanide by photoaffinity labeling, 5232 DNA sequence transfer between two high-cysteine chorion gene families Biochemical cycle in the silkmoth Bombyx mori, 4452 Soliton-assisted unidirectional circulation in a biochemical cycle, 4386 In vitro transcription of a silkworm 5S RNA gene requires an upstream Biological system interactions signal, 5519 Biological system interactions, 2938 Bone Bioluminescence In vitro transformation of mesenchymal cells derived from embryonic Characterization and postulated structure of the primary emitter in the muscle into cartilage in response to extracellular matrix components of bacterial luciferase reaction, 2990 bone, 3419 Identification of genes and gene products necessary for bacterial Macrophage-derived growth factor for osteoblast-like cells and bioluminescence, 4154 chondrocytes, 4558 Biorhythm Bone-Gla protein Transitions between oscillatory modes in a glycolytic model system, 4394 Monoclonal antibodies to native noncollagenous bone-specific Blotin proteins, 2868 Avidin-biotin affinity chromatography: Application to the isolation of human placental insulin receptor, 7328 8052 Biological Sciences Subject Index Proc. Nati. Acad. Sci. USA 81 (1984)

Bone marrow Regional distribution of putative vasopressin receptors in rat brain and Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone pituitary by quantitative autoradiography, 7248 marrow culture obtained from a patient recently infected with hepatitis Lipoprotein lipase is produced, regulated, and functional in rat B virus, 3526 brain, 7604 Bone marrow transplantation Highly selective photoaffinity labeling of jA and 5 opioid receptors, 7718 Selective killing of leukemic cells by merocyanine 540-mediated Mammalian brain and erythrocyte carboxyl methyltransferases are similar photosensitization, 7584 enzymes that recognize both D-aspartyl and L-isoaspartyl residues in Bone morphogenetic protein structurally altered protein substrates, 7757 Purification of bovine bone morphogenetic protein by hydroxyapatite Partial purification and functional expression of brain mRNAs coding for chromatography, 371 neurotransmitter receptors and voltage-operated channels, 7994 Bone proteoglycan Brain development Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of Isolation of cDNA clones for the chicken neural cell adhesion molecule bovine osteogenesis imperfecta, 2213 (N-CAM), 5584 Bone resorption Heterogeneity of microtubule-associated protein 2 during rat brain Thymus-derived lymphocytes and their interactions with macrophages are development, 5613 required for the production of osteoclast-activating factor in the Brain membrane mouse, 2181 a opiates and jertain antipsychotic drugs mutually inhibit (+)-[3H]SKF Bone-specific protein 10,047 and [ H]haloperidol binding in guinea pig brain membranes, 5618 Monoclonal antibodies to native noncollagenous bone-specific Brain metabolism proteins, 2868 Detection of cerebral lactate in vivo during hypoxemia by 'H NMR at Boron relatively low field strengths (1.9 T), 2517 Neutron-capture therapy of human cancer: In vivo results on tumor Brain microvessel localization of boron-10-labeled antibodies to carcinoembryonic antigen Identification and characterization of the glucose transporter of the in the GW-39 tumor model system, 560 blood-brain barrier by cytochalasin B binding and immunological Bovine leukemia virus reactivity, 7233 Bovine leukemia virus: Unique structural features of its long terminal Brain protein repeats and its evolutionary relationship to human T-cell leukemia Purification and characterization of acidic growth factor from virus, 4741 bovine brain, 357 Bovine papilloma virus Brain-retrocerebral complex Synthesis and glycosylation of the common a subunit of human In vitro reprogramming of the photoperiodic clock in an insect brain- glycoprotein hormones in mouse cells, 6701 retrocerebral complex, 5881 Bovine papillomavirus Brain size Constitutive production of human interferons by mouse cells with bovine Population differences in complexity of a learned skill are correlated with papillomavirus as a vector, 5086 the brain space involved, 6232 Identification of a second transforming region in bovine papillomavirus Brain stimulation DNA, 7880 Changes in local cerebral glucose utilization during rewarding brain Bovine serum albumin stimulation, 635 Interactions of myristic acid with bovine serum albumin: A 13C NMR Brain transplant study, 3718 The survival of brain transplants is enhanced by extracts from injured Brain brain, 6250 Monoclonal antibodies detect the conservation of muscarinic cholinergic Branched-chain a-keto acid dehydrogenase receptor structure from Drosophila to human brain and detect possible Purification and properties of branched-chain a-keto acid dehydrogenase structural homology with a1-adrenergic receptors, 272 phosphatase, 4335 Brain-specific genes have identifier sequences in their , 713 Breast cancer cell line Autoradiographic localization of angiotensin II receptors in rat Activation of pS2 gene transcription is a primary response to estrogen in brain, 1575 the human breast cancer cell line MCF-7, 6344 Quantitative autoradiography of 131- and ,2-adrenergic receptors in rat Breast carcinoma cell brain, 1585 Properties of retrovirus-like particles produced by a human breast Autoradiographic visualization of angiotensin-converting enzyme in rat carcinoma cell line: Immunological relationship with mouse mammary brain with [3Hicaptopril: Localization to a striatonigral pathway, 1599 Increase in the Bmax of y-aminobutyric acid-A recognition sites in brain tumor virus proteins, 4188 regions of mice receiving diazepam, 2247 Brome mosaic virus Developmental studies of phospholipid-sensitive Ca2 -dependent protein Striking similarities in amino acid sequence among nonstructural proteins kinase and its substrates and of phosphoprotein phosphatases in rat encoded by RNA viruses that have dissimilar genomic brain, 3143 organization, 4358 Glycine-directed peptide amidation: Presence in rat brain of two enzymes Multicomponent RNA plant virus infection derived from cloned viral that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 cDNA, 7066 (thyrotropin-releasing hormone), 3228 5-Bromo-4-chloro-3-indolyl P-D-galactoside Brain fodrin: Substrate for calpain I, an endogenous calcium-activated Construction of Tn5 lac, a transposon that fuses lacZ expression to protease, 3572 exogenous promoters, and its introduction into Myxococcus Heterogeneity of vertebrate brain , 4041 xanthus, 5816 Relationships between the structures of taxol and baccatine III 8-Bromoguanosine derivatives and their in vitro action on the disassembly of mammalian Intracellular lymphocyte activation and carrier-mediated transport of C8- brain and Physarum amoebal microtubules, 4090 substituted guanine ribonucleosides, 862 Solubilization and characterization of g, 8, and K opioid binding sites Brownian motion from guinea pig brain: Physical separation of K receptors, 4217 Theory of Mossbauer spectra of proteins fluctuating between Solubilization and characterization of thyrotropin-releasing hormone conformational substates, 5719 receptors from rat brain, 4227 A consistent picture of protein dynamics, 7088 Cloned cDNA to cholecystokinin mRNA predicts an identical Browning preprocholecystokinin in pig brain and gut, 4307 Modification of DNA by reducing sugars: A possible mechanism for Identification of glucagon receptors in rat brain, 4368 nucleic acid aging and age-related dysfunction in gene expression, 105 Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6- Accelerated age-related browning of human collagen in diabetes tetrahydropyridine: Characterization and localization of receptor mellitus, 583 binding sites in rat and human brain, 4591 Aging of proteins: Isolation and identification of a fluorescent Binding of [3Hlforskolin to rat brain membranes, 5081 chromophore from the reaction of polypeptides with glucose, 2684 Immunocytochemical localization of calcium/calmodulin-dependent a-Bungarotoxin protein kinase II in rat brain, 5604 Binding of a-bungarotoxin to proteolytic fragments of the a subunit of Production and characterization of monoclonal antibodies with specificity Torpedo acetylcholine receptor analyzed by protein transfer on for the S100(3 polypeptide of brain S100 fractions, 6034 positively charged membrane filters, 2553 Leukotrienes in the rat central nervous system, 6212 Shared antigenic determinant between the Electrophorus acetylcholine Homonuclear 1H double-resonance difference spectroscopy of the rat receptor and a synaptic component on chicken ciliary ganglion brain in vivo, 6330 neurons, 3223 Brain- and liver cell-derived factors are required for growth of human Burkitt lymphoma endothelial cells in serum-free culture, 6413 Possible DNA-RNA tumor virus interaction in human lymphomas: Isolation of a large cholecystokinin precursor from canine brain, 6565 Expression of retroviral proteins in Ramos lymphoma lines is enhanced Enzymes processing somatostatin precursors: An Arg-Lys after conversion with Epstein-Barr virus, 33 esteropeptidase from the rat brain cortex converting somatostatin-28 The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts into somatostatin-14, 6662 the VK locus, 2444 Selective association of N-methyl aspartate and quisqualate types of L- Translocated c-myc oncogene of Burkitt lymphoma is transcribed in glutamate receptor with brain postsynaptic densities, 6876 plasma cells and repressed in lymphoblastoid cells, 3170 Evolutionary conservation of key structures and binding functions of Induction of plasmacytoid differentiation by phorbol ester in B-cell neural cell adhesion molecules, 6881 lymphoma cell lines bearing 8;14 translocations, 3547 Isolation of brain fibroblast growth factor by heparin-Sepharose affinity Possible DNA-RNA tumor virus interaction in human lymphomas: chromatography: Identity with pituitary fibroblast growth factor, 6963 Expression of retroviral proteins in Ramos lymphoma lines is enhanced The presence of pig brain of an endogenous equivalent of apamin, the bee after conversion with Epstein-Barr virus (Correction), 3918 venom peptide that specifically blocks Ca2+-dependent K+ Detection of an Epstein-Barr virus-associated membrane antigen in channels, 7228 Epstein-Barr virus-transformed nonproducer cells by leukocyte migration inhibition and blocking antibody, 4178 The protein encoded by the human proto-oncogene c-myc, 7742 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984) 8053

Burkitt lymphoma cell The increase in intracellular free calcium associated with IgGy2b/yl Fc No evidence for differences in the Epstein-Barr virus genome carried in receptor-ligand interactions: Role in phagocytosis, 5430 Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from Immunocytochemical localization of calcium/calmodulin-dependent the same patients, 4930 protein kinase II in rat brain, 5604 Bursal tumor Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 Proviral deletions and oncogene base-substitutions in insertionally cells: Role of Ca2+-sensitive phospholipid-dependent protein mutagenized c-myc alleles may contribute to the progression of avian kinase, 5748 bursal tumors, 843 Leukotriene B4 mobilizes calcium without the breakdown of Burst-fornung unit polyphosphoinositides and the production of phosphatidic acid in rabbit Mouse yolk sac and intraembryonic tissues produce factors able to elicit Ceutrophils, 5966 differentiation of erythroid burst-forming units and colony-forming Ca + causes active contraction of bile canaliculi: Direct evidence from units, respectively, 1453 microinjection studies, 6164 Burst-promoting activity Modillation of chloroplast movement in the green alga Mougeotia by the Mouse yolk sac and intraembryonic tissues produce factors able to elicit CaW+ ionophore A23187 and by calmodulin antagonists, 6368 differentiation of erythroid burst-forming units and colony-forming Calcium-dependent, cyclic nucleotide-independent steroidogenesis in the units, respectively, 1453 bovine placenta, 6403 Movement of scallop myosin on Nitella actin filaments: Regulation by Butyrate calcium, 6775 Activation of a chicken embryonic globin gene in adult erythroid cells by Monocytes are required to trigger Ca2+ uptake in the proliferative 5-azacytidine and sodium butyrate, 3954 response of human T lymphocytes to Staphylococcus aureus protein Butyrylcholinesterase A, 6827 Partial characterization of the neurotrophic factor for maintenance of Calcium dependency of antigen-specific (T3-Ti) and alternative (Til) acetyicholinesterase and butyrylcholinesterase in the preganglionically pathways of human T-cell activation, 6836 denervated superior cervical ganglion of the cat in vivo, 6539 The increase in intracellular free calcium associated with IgGy2b/y1 Fc Bystander stimulation receptor-ligand interactions: Role in phagocytosis (Correction), 7258 Single-cell studies on hapten-specific B cells: Response to T-cell- myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in dependent antigens, 2479 saponin-pe meabilized human platelets, 7431 Defective Ca l+ etabolism in Duchenne muscular dystrophy: Effects on cellular and viral growth, 7617 C-C-G-G sequence Serotonin increases intracellular Ca2+ transients in voltage-clamped DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' sensory neurons of Aptysia californica, 7642 region inactivate the E2a gene of adenovirus type 2, 2950 Calcium/phospholipid-dependent protein kinase (protein kinase C) (C-G), phosphorylates and activates tyrosine hydroxylase, 7713 Restriction endonucleases can be used to study B-Z junctions in Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis supercoiled DNA, 5714 and phosphoinositide hydrolysis and mobilizes intracellular calcium in Cadmium cultured arterial muscle cells, 7812 Evidence for the involvement of coupling factor B in the H' channel of Calcium binding protein the mitochondrial H+-ATPase, 1371 Aminomalonic acid: Identification in E~scherichia coli and atherosclerotic A 12-base-pair DNA motif that is repeated several times in plaque, 722 metallothionein gene promoters confers metal regulation to a Calcium-binding protein, parvalbumin, is reduced in mutant mammalian heterologous gene, 7318 muscle with abnormal contractile properties, 4814 Caenorhabditis Production and characterization of monoclonal antibodies with specificity A pheromone-induced developmental switch in Caenorhabditis elegans: for the S100,8 polypeptide of brain S100 fractions, 6034 Temperature-sensitive mutants reveal a wild-type temperature- Calcium-binding proteins in human carcinoma cell lines, 6632 dependent process, 819 Calcium channel Extrachromosomal copies of transposon Tcl in the nematode Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive Caenorhabditis elegans, 4018 calcium channels in nerve terminal preparations, 3118 A selection for myosin heavy chain mutants in the nematode Inhibitors of CDP-choline synthesis, action potential calcium channels, Caenorhabditis elegans, 4470 and stimulus-secretion coupling, 4353 The sup-7(stS) X gene of Caenorhabditis elegans encodes a tRNATUG Interactions of maitotoxin with voltage-sensitive calcium channels in amber suppressor, 6784 cultured neuronal cells, 4582 Caffeine Dihydropyridine derivatives prolong the open state of Ca channels in Adenosine strongly potentiates pressor responses to nicotine in rats, 5599 cultured cardiac cells, 4824 Calcium A Ca2 -activated channel from Xenopus laevis oocyte membranes Cytosolic Ca2'-dependent neutral proteinases from rabbit liver: reconstituted into planar bilayers, 5155 Activation of the proenzymes by Ca2+ and substrate, 53 Calcium channel activation: A different type of drug action, 5580 Electrical activity and cytosolic calcium regulate levels of tetrodotoxin- Facilitation of Ca2+-channel currents in bovine adrenal chromaffin sensitive sodium channels in cultured rat muscle cells, 262 cells, 5871 Cytosolic calcium regulates epidermal growth factor endocytosis in rat Nitrendipine block of cardiac calcium channels: High-affinity binding to pancreas and cultured fibroblasts, 461 the inactivated state, 6388 Free cytoplasmic Ca2' and neurotransmitter release: Studies on PC12 The cromolyn binding protein constitutes the Ca2+ channel of basophils cells and synaptosomes exposed to a-latrotoxin, 620 opening upon immunological stimulus, 6841 Evidence that the major postsynaptic density protein is a component of a Calcium channel blocker Ca2+/calmodulin-dependent protein kinase, 945 Interaction of calcium channel blockers with non-neuronal Kindling alters the calcium/calmodulin-dependent phosphorylation of benzodiazepine binding sites, 1549 synaptic plasma membrane proteins in rat hippocampus, 1253 Charge movement in skeletal muscle fibers paralyzed by the calcium- Monitoring of cytosolic free Ca2+ in C5a-stimulated neutrophils: Loss of entry blocker D600, 2582 receptor-modulated Ca2+ stores and Ca2+ uptake in granule-free cytoplasts, 1416 Calcium ionophore A23187 Imaging of calcium and aluminum in neurofibrillary tangle-bearing Modulation of chloroplast movement in the green alga Mougeotia by the neurons in parkinsonism-dementia of Guam, 1875 Ca2 ionophore A23187 and by calmodulin antagonists, 6368 Complex carbohydrate diets are not capable of maintaining normal Calcium pump plasma calcium and phosphorus levels in vitamin D-deficient rats, 2352 Monomeric solubilized sarcoplasmic reticulum Ca pump protein: Relationship between parathyroid hormone secretion and cytosolic Demonstration of Ca binding and dissociation coupled to ATP calcium concentration in dispersed bovine parathyroid cells, 3113 hydrolysis, 6623 Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary Calcium transporter muscle preparations from guinea pig heart by analogs of amiloride, 3238 Isolation, purification, and reconstitution of the Na+ gradient-dependent Conformational analysis of 6-cis- and 6-trans-leukotriene B4-calcium Ca transporter (Na'-Ca + exchanger) from brain synaptic plasma complexes, 3370 membranes, 6521 Brain fodrin: Substrate for calpain I, an endogenous calcium-activated Caldesmon protease, 3572 Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: Inhibition by calmodulin of calcium/phospholipid-dependent protein Comparison of normal and transformed cells, 3133 phosphorylation, 3622 Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: Neurotransmitter receptors mediate cyclic GMP formation by Comparison of normal and transformed cells (Correction), 6548 involvement of arachidonic acid and lipoxygenase, 3905 Callus Direct demonstration of increased intracellular concentration of free Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts calcium as measured by quin-2 in stimulated rat peritoneal mast by promoting cortical microtubule assembly, 5449 cell, 3978 Calnodulln Role of T3 surface molecules in human T-cell activation: T3-dependent Evidence that the major postsynaptic density protein is a component of a activation results in an increase in cytoplasmic free calcium, 4169 Ca2+/calmodulin-dependent protein kinase, 945 Potentiation of a1-adrenergic responses in rat liver by a cAMP-dependent Kindling alters the calcium/calmodulin-dependent phosphorylation of mechanism, 4208 synaptic plasma membrane proteins in rat hippocampus, 1253 Single channel recordings of calcium-activated potassium channels in the Calmodulin inhibitor in senescing apples and its physiological and apical membrane of rabbit cortical collecting tubules, 4237 pharmacological significance, 2065 Imaging of calcium and aluminum in neurofibrillary tangle-bearing Catalytic site of calmodulin-dependent from bovine neurons in parkinsonism-dementia of Guam (Correction), 4240 brain resides in subunit A, 3054 Ca2+/calmodulin-dependent protein kinases from the neuronal nuclear Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: matrix and post-synaptic density are structurally related, 4311 Comparison of normal and transformed cells, 3133 Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation, 3622 8054 Biological Sciences Subject Index Proc. Nati. Acad. Sci. USA 81 (1984)

Ca2+/calmodulin-dependent protein kinases from the neuronal nuclear P-Carboxyaspartic acid matrix and post-synaptic density are structurally related, 4311 Aminomalonic acid: Identification in Escherichia coli and atherosclerotic Infection of B lymphocytes by a human herpesvirus, Epstein-Barr virus, plaque, 722 is blocked by calmodulin antagonists, 4955 -Carboxyglutamic acid Immunocytochemical localization of calcium/calmodulin-dependent Aminomalonic acid: Identification in Escherichia coli and atherosclerotic protein kinase II in rat brain, 5604 plaque, 722 Calmodulin-stimulated phosphorylation of 17f-estradiol receptor on Carboxyl methyltransferase tyrosine, 5921 Mammalian brain and erythrocyte carboxyl methyltransferases are similar Modulation of chloroplast movement in the green alga Mougeotia by the enzymes that recognize both D-aspartyl and L-isoaspartyl residues in Ca2+ ionophore A23187 and by calmodulin antagonists, 6368 structurally altered protein substrates, 7757 Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: Carboxyl terminus Comparison of normal and transformed cells (Correction), 6548 Intramolecular dislocation of the COOH terminus of the lac carrier Caloric restriction protein in reconstituted proteoliposomes, 4672 Reduction in the incidence of radiation-induced tumors in rats after rCarboxylation restriction of food intake, 75% Mechanism of the inhibition of the y-carboxylation of by N- Calpain methylthiotetrazole-containing antibiotics, 2893 Brain fodrin: Substrate for calpain I, an endogenous calcium-activated Carboxypeptidase protease, 3572 Enkephalin convertase localization by cAMP [-Higuanidinoethylmercaptosuccinic acid autoradiography: Selective See Cyclic AMP association with enkephalin-containing neurons, 6543 Camphor hydroxylase Carboxypeptidase A Camphor hydroxylase of Pseudomonas putida: Vestiges of sequence Cryospectrokinetic characterization of intermediates in biochemical homology in cytochrome P-450CAM, putidaredoxin, and related reactions: Carboxypeptidase A, 5041 proteins, 1664 Effects of pH on the structure and function of carboxypeptidase A: Cancer Crystallographic studies, 7767 Human anti-idiotype antibodies in cancer patients: Is the modulation of Carboxypeptidase B the immune response beneficial for the patient?, 216 Carboxypeptidase B-like converting enzyme activity in secretory granules Invasive behavior of mouse sarcoma cells is inhibited by blocking a of rat pituitary, 2776 37,000- plasma membrane glycoprotein with Fab fragments, 3747 Carcinoembryonic antigen Thymine glycol and thymidine glycol in human and rat urine: A possible Neutron-capture therapy of human cancer: In vivo results on tumor assay for oxidative DNA damage, 5633 localization of boron-10-labeled antibodies to carcinoembryonic antigen Carotenoids and retinol: Their possible importance in determining in the GW-39 tumor model system, 560 longevity of primate species, 7627 Second antibody clearance of radiolabeled antibody in cancer Cancer radioimmunodetection radioimmunodetection, 2843 Second antibody clearance of radiolabeled antibody in cancer Generation of antibody activity from immunoglobulin polypeptide chains radioimmunodetection, 2843 produced in Escherichia coli, 3273 Cancer therapy Carcinogen Neutron-capture therapy of human cancer: In vivo results on tumor Construction and characterization of extrachromosomal probes fQr localization of boron-10-labeled antibodies to carcinoembryonic antigen mutagenesis by carcinogens: Site-specific incorporation of O6- in the GW-39 tumor model system, 560 methylguanine into viral and plasmid genomes, 13 Capillary A molecular approach to leukemogenesis: Mouse lymphomas contain an Differential adhesion of tumor cells to capillary endothelial cells in activated c-ras oncogene, 202 vitro, 5739 Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene De novo cellular synthesis of sulfated proteoglycans of the developing sequences of rat liver DNA, 664 renal glomerulus in vivo, 7108 Inhibition of DNA synthesis by an electrophilic metabolite of Captopril benzo[alpyrene, 5300 Autoradiographic visualization of angiotensin-converting enzyme in rat Site-specific carcinogen binding to DNA, 5623 brain with [3H]captopril: Localization to a striatonigral pathway, 1599 Target polypeptide of a carcinogen is associated with normal mitosis and Carbamate carcinogen-induced hyperplasias in adult hepatocytes, 6738 Active-site carbamate formation and reaction-intermediate-analog binding Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene by ribulosebisphosphate carboxylase/oxygenase in the absence of its to repetitive sequences of rat liver DNA in vivo, 6943 small subunits, 3660 High-affinity monoclonal antibodies for aflatoxins and their application to Carbamoyl-phosphate synthetase solid-phase immunoassays, 7728 DNA sequence of the carA gene and the control region of carAB: Carcinogen-DNA adduct Tandem promoters, respectively controlled by arginine and the Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase DNA proceed through similar rate-determining steps, 2635 in Escherichia coli K-12, 4134 Carbamoylcholine 04-Ethyldeoxythymidine, but not 06-ethyldeoxyguanosine, accumulates Activation of Ca-dependent K channels by carbamoylcholine in rat in hepatocyte DNA of rats exposed continuously to lacrimal glands, 611 diethylnitrosamine, 1692 Carbohydrate Protease inhibitors reduce the frequency of spontaneous chromosome Complex carbohydrate diets are not capable of maintaining normal abnormalities in cells fronm patients with Bloom syndrome, 1827 plasma calcium and phosphorus levels in vitamin D-deficient rats, 2352 Normal liver chromatin contains a firmly bound and larger protein related to the principal cytosolic target polypeptide of a hepatic Potentiation of a1-adrenergic responses in rat liver by a cAMP-dependent carcinogen, 2092 mechanism, 4208 Malignant growth in the normal host after variant selection in vitro with cytolytic T-cell lines, 2186 Carbohydrate side chain Cholesterol epoxide is a direct-acting mutagen, 4198 A carbohydrate side chain on hemagglutinins of Hong Kong influenza Induction of replicative DNA synthesis in quiescent human fibroblasts by viruses inhibits recognition by a monoclonal antibody, 1779 DNA damaging agents, 4828 Carbohydrate structure Regulation of glutathione transferase and DT-diaphorase mRNAs in Rapid release of -terminated ligands after endocytosis by hepatic persistent hepatocyte nodules during chemical parenchymal cells: Evidence for a role of carbohydrate structure in the hepatocarcinogenesis, 5091 release of internalized ligand from receptor, 466 Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate- Carbon-13 NMER effected tumor promotion in mouse skin by nontoxic inhibition of DNA Detection of cis and trans X-Pro peptide bonds in proteins by 13C NMR: synthesis, 5858 Application to collagen, 4800 Use of short DNA oligonucleotides for determination of DNA sequence modifications induced by benzo[alpyrene diol epoxide, 5936 Biosynthesis of carbonic anhydrase in Chlamydomonas reinhardtii during In vivo mutagenesis by 06-methylguanine built into a unique site in a viral adaptation to low C02, 6049 genome, 6271 Carbon dioxide fixation Carcinoma Role of carbon monoxide dehydrogenase in the autotrophic pathway used Isolation of transforming sequences of two human lung carcinomas: by acetogenic bacteria, 6261 Structural and functional analysis of the activated c-K-ras Carbon monoxide oncogenes, 71 Iron-carbon bond lengths in carbonmonoxy and cyanomet complexes of Cell surface antigens of human ovarian and endometrial carcinoma the monomeric hemoglobin III from Chironomus thummi thummi: A defined by mouse monoclonal antibodies, 568 critical comparison between resonance Raman and x-ray diffraction Development of methotrexate resistance in a human squamous cell studies, 5106 _ carcinoma of the head and neck in culture, 2873 Carbon monoxide dehydrogenase Differences in keratin synthesis between normal epithelial cells and Role of carbon monoxide dehydrogenase in the autotrophic pathway used squamous cell carcinomas are mediated by vitamin A, 4280 by acetogenic bacteria, 6261 Aberrant expression of an amplified c-myb oncogene in two cell lines Carbonic anhydrase from a colon carcinoma, 4534 Biosynthesis of carbonic anhydrase in Chlamydomonas reinhardtii during Development of methotrexate resistance in a human squamous cell to low 6049 carcinoma of the head and neck in culture (Correction), 5006 adaptation C02, Monoclonal antibodies of predefined specificity detect activated ras gene Carbonmonoxyhemoglobin expression in human mammary and colon carcinomas, 5227 Magnetic susceptibility of oxy- and carbonmonoxyhemoglobins, 5417 Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma, 5242 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984) 8055

Carcinoma cell Cation, aromatic Mechanism of activation of an N-ras oncogene of SW-1271 human lung Condensation of nucleic acids by intercalating aromatic cations, 7368 carcinoma cells, 3670 Cauliflower mosaic virus Epidermal growth factor inhibits the synthesis of the nuclear protein Detection in vivo of a new gene product (gene III) of cauliflower mosaic cyclin in A431 human carcinoma cells, 4848 virus, 6608 Calcium-binding proteins in human carcinoma cell lines, 6632 Caulobacter Cardiac cell Generation of a TnS promoter probe and its use in the study of gene Dihydropyridine derivatives prolong the open state of Ca channels in expression in Caulobacter crescentus, 1035 cultured cardiac cells, 4824 Analysis of the pleiotropic regulation of flagellar and chemotaxis gene Cardiac dysrhythmia expression in Caulobacter crescentus by using plasmid Simple finite-element model accounts for wide range of cardiac complementation, 1341 dysrhythmias, 233 Isolation of flagellated membrane vesicles from Caulobacter crescentus Cardiac peptide cells: Evidence for functional differentiation of polar membrane Proteolytic activation of a bioactive cardiac peptide by in vitro trypsin domains, 3409 cleavage, 1230 cDNA Cardiac ventricle Cloning of a cDNA encoding rat intestinal fatty acid binding protein, 313 Immunofluorescence analysis of the primordial myosin detectable in Cloning and sequence analysis of a cDNA encoding rat embryonic striated muscle, 797 preprocholecystokinin, 726 Androgen induction of ornithine decarboxylase mRNA in mouse kidney Cardioacceleration as studied by complementary DNA, 731 Isolation and primary structure of two peptides with cardioacceleratory Isolation and characterization of a mouse cDNA clone that expresses and hyperglycemic activity from the corpora cardiaca of Periplaneta mast-cell growth-factor activity in monkey cells, 1070 americana, 5575 Isolation of cDNA clones for human complement component C2, 1212 Cardiodilatin Isolation of a collagenase cDNA clone and measurement of changing Molecular cloning and characterization of DNA sequences encoding rat collagenase mRNA levels during induction of rabbit synovial and human atrial natriuretic factors, 6325 fibroblasts, 1981 Carotenoid Cloning and expression of cDNA encoding a bovine adrenal cytochrome Carotenoids and retinol: Their possible importance in determining P-450 speciffc for steroid 21-hydroxylation, 1986 longevity of primate species, 7627 Cell-type-specific cDNA probes and the murine I region: The localization Carpal tunnel syndrome and orientation of Ad, 2194 Enzymology of the response of the carpal tunnel syndrome to riboflavin Sequence of a complete chicken 8-crystallin cDNA, 2611 and to combined riboflavin and pyridoxine' 7076 Human transferrin: cDNA characterization and chromosomal Carrot localization, 2752 Electrical polarity in embryos of wild carrot precedes cotyledon Isolation and identification of a cDNA clone coding for rat differentiation, 6064 uroporphyrinogen decarboxylase, 3346 Cartilage Biologically active protease of foot and mouth disease virus is expressed Synthesis and characterization of cDNA encoding a cartilage-specific from cloned viral cDNA in Escherichia coli, 3351 short collagen, 3014 Characterization of a cDNA coding for human factor X, 3699 In vitro transformation of mesenchymal cells derived from embryonic Characterization of a cDNA coding for human protein C, 4766 muscle into cartilage in response to extracellular matrix components of Intermediate filament cDNAs from BHK-21 cells: Demonstration of bope, 3419 distinct genes for desmin and vimentin in all vertebrate classes, 5970 Casein Cell-cycle-specific cDNAs from mammalian cells temperature sensitive Epithelial mouse mammary cell line exhibiting normal morphogenesis in for growth, 6004 vivo and functional differentiation in vitro, 3756 Expression of a human a,-antitrypsin cDNA in the yeast Saccharomyces Casein kiase cerevisiae, 6594 New protein kinase from plasma membrane of Ehrlich ascites tumor cells Nucleotide sequence of cDNA and derived amino acid sequence of activated by natural polypeptides, 4250 human complement component C9, 7298 Molecular cloning and nucjpotide sequence of cDNA for rat ornithine Caste regulation carbamoyltransferase precursor, 7412 Soldier formation regulated by a primer pheromone from the soldier F-Crystallin family of the mouse lens: Structural and evolutionary frontal gland in a higher termite, Nasutitermes lujae, 7665 relationships, 7762 Castration Nucleotide sequence of human monocyte interleukin 1 precursor Simultaneous administration of pure antiandrogens, a combination cDNA, 7907 necessary for the use of luteinizing hormone-releasing hormone cDNA clone agonists in the treatment of prostate cancer, 3861 Complete amino acid sequence for human aldolase B derived from cDNA Cat and genomic clones, 2738 Remission of leukemia and loss of feline leukemia virus in cats injected Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: with Staphylococcus protein A: Association with increased circulating Structural conservatiop of intermediate filaments, 2743 interferon and complement-dependent cytotoxic antibody, 6471 Isolation of cloned cDNA encoding mammalian ornithine Catabolite gene activator protein decarboxylase, 3645 Model of specific complex between catabolite gene activator protein and Cloned cDNA to cholecystokinin mRNA predicts an identical B-DNA suggested by electrostatic complementarity, 3973 preprocholecystokinin in pig brain and gut, 4307 Molecular basis of DNA sequence recognition by the catabolite gene Isolation and characterization of a cDNA clone for human ferritin heavy activator protein: Detailed inferences from three mutations that alter chain, 4751 DNA sequence specificity, 7274 A cDNA clone encoding neuropeptides isolated from Aplysia neuron Catabolite repression L11, 4988 Catabolite repression of chloroplast development in Euglena, 2786 cDNA clone for the a-chain of human 8-: Deficiency of Regulation of the araC gene of Escherichia coli: Catabolite repression, a-chain mRNA in Ashkenazi Tay-Sachs fibroblasts, 5394 autoregulation, and effect of araBAD expression, 4120 Isolation of cDNA clones for the chicken neural cell adhesion molecule Catalase (N-CAM), 5584 Catalase: A tetrameric enzyme with four lightly bound molecules of Identification and characterization of cDNA clones specific for NADPH, 4343 cholesterol side-chain cleavage cytochrome P450, 5628 Maturation of catalase precursor proceeds to a different extent in The complete cDNA gnd deduced amino acid sequence of a type II glyoxysomes and leaf peroxisomes of pumpkin cotyledons, 4809 mouse epidermal keratin of 60,000 Da: Analysis of sequence differences between type I and type II keratins, 5709 Dynamics of enzymatic reactions, 444 Isolation and characterization of a cDNA clone for bovine cytochrome c A model for the origin of biological catalysis, 1751 oxidase subunit IV, 6295 A model for the origin of biological catalysis (Correction), 4599 Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein, 6822 Cataract Isolation and characterization of a cDNA clone for the y subunit of Nondisuffide polymerization of y- and ,8-crystallins in the human bovine retinal trpansducin, 6948 lens, 2878 Analysis of virus mRNAs with cDNA clones of viral genes and Catecholamine sequencesSenqaiof biologically important regions of the fusion protein, 7732 Intrinsic GABAergic system of adrenal chromaffin cells, 3218 Isolation and characterization of a cDNA clone for the complete protein Changes in rat adrenal catecholamines and proenkephalin metabolism coding region of the 6 subunit of the mouse acetylcholine after denervation, 3587 receptor, 7970 Calcium/phospholipid-dependent protein kinase (protein kinase C) cDNA, cloned phosphorylates and activates tyrosine hydrozylase, 7713 Multicomponent RNA plant virus infection derived from cloned viral Catenane 7066 DNA topoisomerase II mutant of Saccharomyces cerevisiae: cDNA, Topoisomerase II is required for segregation of daughter molecules at cDNA cloning the termination of DNA replication, 2616 Cloning and structure determination of cDNA for , an enzyme of DNA involved in fungal penetration of plants, 3939 A simple topological method for describing stereoisomers Molecular cloning and characterization of a cDNA cloning for the /3 catenanes and knots, 3322 subunit of human alcohol dehydrogenase, 4055 Cathepsin D Cloning of cDNAs specifying vitamin A-responsive human keratins, 4321 Cathepsin D-mediated processing of procollagen: Lysosomal enzyme Cloning, characterization, and DNA sequence of a human cDNA involvement in secretory processing of procollagen, 3302 encoding neuropeptide tyrosine, 4577 Amino acid sequence of porcine spleen cathepsin D, 3703 Expression of a biologically active fragment of human IgE e chain in Escherichia coli, 5369 8056 Biological Sciences Subject Index Proc. Natl. Acad. Sci USA 81 (1984)

Cloning and sequencing of liver cDNA coding for bovine protein C, 5653 Activation and fusion induced by la,25-dihydroxyvitamin D3 and their Cloning and characterization of cDNAs encoding human gastrin-releasing relation in alveolar macrophages, 7P12 peptide, 5699 Tumorigenicity of cell lines with altered lipid composition, 7622 Cloning of terminal transferase cDNA by antibody screening, 5836 Toxin-antitoxin selection for isolating somatic cell fusion products Molecular cloning and characterization of DNA sequences encoding rat between any cell types, 7822 and human atrial natriuretic factors, 6325 Cell growth Molecular cloning of a cDNA for the chicken progesterone receptor B Cell growth and net Na' flux are inhibited by a protein produced by antigen, 6358 kidney epithelial cells in culture, 793 Circumsporozoite gene of Plasmodium cynomolgi (Gombak): cDNA Biological system interactions, 2938 cloning and expression of the repetitive circumsporozoite epitope, 7520 Loss of reciprocal modulations of growth and liver function of hepatoma Molecular cloning and sequence determination of rat preproenkephalin cells in culture by contact with cells or cell membranes, 6398 cDNA: Sensitive probe for studying transcriptional changes in rat Cell heterogeneity tissues, 7651 Early origin and pervasiveness of cellular heterogeneity in some cDNA subtraction malignant transformations, 5121 Isolation of the gene encoding the human T-lymphocyte differentiation Outline of a theory of cellular heterogeneity, 5126 antigen Leu-2 (T8) by gene transfer and cDNA subtraction, 7688 Cell movement CDP-choline Monitoring fibroblast behavior in tissue culture with an applied electric Inhibitors of CDP-choline synthesis, action potential calcium channels, field, 3761 and stimulus-secretion coupling, 4353 Cell proliferation Cell activation Synthetic somatomedin C: Comparison with natural hormone isolated Imbalance of total cellular nucleotide pools and mechanism of the from human plasma, 740 colchicine-induced cell activation, 2401 Benzodiazepines that bind at peripheral sites inhibit cell proliferation, 753 Cell adhesion Distinct mechanisms may account for the growth-promoting activity of Cell adhesion and morphogenesis: The regulator hypothesis, 1460 interleukin 3 on cells of lymphoid and myeloid origin, 1208 Leukotriene B4 action on endothelium mediates augmented neutrophil/ Expression of the transformation-sensitive protein "cyclin" in normal endothelial adhesion, 2191 human epidermal basal cells and simian virus 40-transformed Human autoantibodies against desmosomes: Possible causative factors in keratinocytes, 3128 pemphigus, 2781 Epidermal growth factor inhibits the synthesis of the nuclear protein Differential adhesion of tumor cells to capillary endothelial cells in cyclin in A431 human carcinoma cells, 4848 vitro, 5739 Isolation and partial molecular characterization of pituitary fibroblast Variants of the cell recognition site of fibronectin that retain attachment- growth factor, 5364 promoting activity, 5985 Nature and origin of the RNA associated with simian virus 40 large tumor Cell adhesion molecule antigen, 5425 Two antigenically related neuronal cell adhesion molecules of different Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised specificities mediate neuron-neuron and neuron-glia adhesion, 267 extracellular magnesium induce proliferation of chicken heart Cell adhesion and morphogenesis: The regulator hypothesis, 1460 mesenchymal cells, 6418 Alteration of the retinotectal map in Xenopus by antibodies to neural cell Antigen-specific helper T-cell clone supernatant is sufficient to induce adhesion molecules, 4222 both polyclonal proliferation and differentiation of small resting B Isolation of cDNA clones for the chicken neural cell adhesion molecule lymphocytes, 6491 (N-CAM), 5584 Monocytes are required to trigger Ca2+ uptake ipi the proliferative Linear organization of the liver cell adhesion molecule L-CAM, 5787 response of human T lymphocytes to Staphylococcus aureus protein Evolutionary conservation of key structures and binding functions of A, 6827 neural cell adhesion molecules, 6881 Schwann cell proliferation and localized proteolysis: Expression of Polypeptide components and binding functions of neuron-glia cell plasminogen-activator activity predominates in the proliferating cell adhesion molecules, 7989 populations, 7216 Cell adhesiveness Colony-stimulating factor (CSF) controls proliferation of CSF-dependent Increased adhesiveness of Down syndrome fetal fibroblasts in vitro, 2426 cells by acting during the GI phase of the cell cycle, 7451 Cell aggregation Evidence for an intracellular precursor for human B-cell growth Increased adhesiveness of Down syndrome fetal fibroblasts in vitro, 2426 factor, 7902 Cell recognition site Cell-cell interaction retain attachment- Identification of a 34,000-dalton mitogenic protein associated with plasma Variants of the cell recognition site of fibronectin that membranes from human A431 epidermoid carcinoma cells, 3399 promoting activity, 5985 The heterogeneity and functional capacities of human thymocyte Cell shape subpopulations, 4912 Plasma membrane reorganization induced by tumor promoters in an Cell colony diameter epithelial cell line, 449 A mutagen-testing assay based on heterogeneity in diameter and Cell spreading integrated optical density of mammalian cell colonies, 2112 Multinucleation-induced improvement of the spreading of transformed cells on the substratum, 3098 Cell cycle Monensin-induced inhibition of cell spreading in normal and dystrophic Identification of a labile protein involved in the GI-to-S transition in Saccharomyces cerevisiae, 120 human fibroblasts, 4960 Cell cycle regulation of human histone H1 mRNA, 434 Cell surface antigen Inhibition of the mitogenic effects of plasma by a monoclonal antibody to Cell surface antigens of human bladder cancer defined by mouse somatomedin C, 2389 monoclonal antibodies, 224 Partial purification and characterization of the mRNA complementing a Cell surface antigens of human ovarian and endometrial carcinoma temperature-sensitive S-phase cell cycle mutation, 2393 defined by mouse monoclonal antibodies, 568 Transcription of human histone genes in extracts from synchronized Immunoprecipitation of cell surface structures of cloned cytotoxic T HeLa cells, 2713 lymphocytes by clone-specific antisera, 573 Cell-cycle-specific cDNAs from mammalian cells temperature sensitive Isolation and partial characterization of concanavalin A receptors on for growth, 6004 cloned cytotoxic T lymphocytes, 1519 Invariant temporal order of replication of the four actin gene loci during Identification and characterization of a monoclonal antibody to an antigen the naturally synchronous mitotic cycles of Physarum expressed on activated macrophages, 4505 polycephalum, 6393 Somatic cell genetic analysis of human cell surface antigens: Colony-stimulating factor (CSF) controls proliferation of CSF-dependent Chromosomal assignments and regulation of expression in rodent- cells by acting during the phase of the cell cycle, 7451 human hybrid cells, 6437 GI Related cell-surface antigens expressed with positional specificity in Cell death Drosophila imaginal discs, 7485 Cyclic GMP may serve as a second messenger in peptide-induced muscle Isolation of the gene encoding the human T-lymphocyte differentiation degeneration in an insect, 6718 antigen Leu-2 (T8) by gene transfer and cDNA subtraction, 7688 Cell density Cell surface charge Loss of reciprocal modulations of growth and liver function of hepatoma Interaction of the 2,6-dimethoxysemiquinone and ascorbyl free radicals cells in culture by contact with cells or cell membranes, 6398 with Ehrlich ascites cells: A probe of cell-surface charge, 2088 Cell division Occurrence of cell division is not exponentially distributed: Differences in Cell surface protein the generation times of sister cells can be derived from the theory of A monoclonal anti-DNA antibody also binds to cell-surface survival of populations, 2379 protein(s), 3843 Inducer-mediated commitment of murine erythroleukemia cells to Polypeptide components and binding functions of neuron-glia cell terminal cell division: The expression of commitment, 3394 adhesion molecules, 7989 Identification of a 34,000-dalton mitogenic protein associated with plasma Cell swelling membranes from human A431 epidermoid carcinoma cells, 3399 Cell swelling increases a barium-inhibitable potassium conductance in the Cell-division control in Escherichia coli: Specific induction of the SOS basolateral membrane of Necturus small intestine, 3591 function SfiA protein is sufficient to block septation, 4490 Cell wall Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts Twisted states of Bacillus subtilis macrofibers reflect structural states of by promoting cortical microtubule assembly, 5449 the cell wall, 3562 Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 Central nervous system cells: Role of Ca2+-sensitive phospholipid-dependent protein Neurotrophic factor for central neurons, 1248 kinase, 5748 Different central nervous system cell types display distinct and Cell fusion nonrandom arrangements of satellite DNA sequences, 3123 Multinucleation-induced improvement of the spreading of transformed Peptides from the regenerating central nervous system of goldfish cells on the substratum, 3098 stimulate glia, 3567 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984) 8057

Structure and molecular arrangement of proteolipid protein of central The role of a signaling protein in bacterial sensing: Behavioral effects of nervous system myelin, 5012 increased gene expression, 5056 Leukotrienes in the rat central nervous system, 6212 Sensory transduction in Escherichia coli: Regulation of the demethylation Developing dorsal root ganglion neurons require trophic support from rate by the CheA protein, 5061 their central processes: Evidence for a role of retrogradely transported Oxidation of leukotrienes at the w end: Demonstration of a receptor for nerve growth factor from the central nervous system to the the 20-hydroxy derivative of leukotriene B4 on human neutrophils and periphery, 6245 implications for the analysis of leukotriene receptors, 5729 Substances originating from the optic nerve of neonatal rabbit induce Chemotherapy regeneration-associated response in the injured optic nerve of adult Antileukemic and immunosuppressive activity of 2-chloro-2'- rabbit, 7965 deoxyadenosine, 2232 Centromere Dipyridamole inhibits reversion by thymidine of methotrexate effect and Different central nervous system cell types display distinct and increases drug uptake in Sarcoma 180 cells, 3200 nonrandom arrangements of satellite DNA sequences, 3123 Transplantation of human or rodent tumors into cyclosporine-treated Characterization of a cloned DNA sequence that is present at mice: A feasible model for studies of tumor biology and centromeres of all human autosomes and the X chromosome and shows chemotherapy, 7927 polymorphic variation, 4884 Chi Centrosome A new class of Escherichia coli recBC mutants: Implications for the role Phosphoproteins are components of mitotic microtubule organizing of RecBC enzyme in homologous recombination, 7850 centers, 4439 Chicken Cereal Identification of the second gonadotropin-releasing hormone in chicken Pepsin digestibility of proteins in sorghum and other major cereals, 1 hypothalamus: Evidence that gonadotropin secretion is probably Cerebellin controlled by two distinct gonadotropin-releasing hormones in avian Isolation and sequencing of two cerebellum-specific peptides, 6866 species, 3874 Cerebellum Chimeric protein Cultures of shiverer mutant cerebellum injected with normal NH2-terminal hydrophobic region of influenza virus oligodendrocytes make both normal and shiverer myelin, 2558 provides the signal function in translocation, 2327 Cerebellum mediates modality-specific modulation of sensory responses Chinese of midbrain and forebrain in rat, 2917 f3-Thalassemia in Chinese: Use of in vivo RNA analysis and Different central nervous system cell types display distinct and oligonucleotide hybridization in systematic characterization of nonrandom arrangements of satellite DNA sequences, 3123 molecular defects, 2821 Neuronal influence on glial enzyme expression: Evidence from mutant Chiral probe mouse cerebella, 4414 Chiral probes for the handedness of DNA helices: Enantiomers of Cerebellum-specific peptide tris(4,7-diphenylphenanthroline)ruthenium(II), 1961 Isolation and sequencing of two cerebellum-specific peptides, 6866 Chironomus Cerebral cortex Iron-carbon bond lengths in carbonmonoxy and cyanomet complexes of Neuropeptide-containing neurons of the cerebral cortex are also the monomeric hemoglobin III from Chironomus thummi thummi: A GABAergic, 6526 critical comparison between resonance Raman and x-ray diffraction Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in studies, 5106 rat cerebellar cortex, 6531 Different evolutionary behavior of structurally related, repetitive Ceruloplasmin sequences occurring in the same Balbiani ring gene in Chironomus Single-chain structure of human ceruloplasmin: The complete amino acid tentans, 5165 sequence of the whole molecule, 390 Chlamydomonas Structural model of human ceruloplasmin based on internal triplication, Chloroplast DNA recombination in interspecific hybrids of hydrophilic/hydrophobic character, and secondary structure of Chlamydomonas: Linkage between a nonmendelian locus for domains, 4761 streptomycin resistance and restriction fragments coding for 16S Coagulation factors V and VIII and ceruloplasmin constitute a family of rRNA, 1164 structurally related proteins, 6934 The persistence of maternal inheritance in Chlamydomonas despite Chalcone synthase hypomethylation of chloroplast DNA induced by inhibitors, 3438 Differential induction of chalcone synthase mRNA activity at the onset of Herbicide resistance in Chlamydomonas reinhardtii results from a phytoalexin accumulation in compatible and incompatible plant- mutation in the chloroplast gene for the 32-kilodalton protein of pathogen interactions, 3384 photosystem II, 3617 Elicitor rapidly induces chalcone synthase mRNA in Phaseolus vulgaris Biosynthesis of carbonic anhydrase in Chlamydomonas reinhardtii during cells at the onset of the phytoalexin defense response, 5724 adaptation to low CO2, 6049 Chaos Chloramphenicol Chaotic behavior in dopamine neurodynamics, 1244 The rnh gene is essential for growth of Escherichia coli, 3447 Transitions between oscillatory modes in a glycolytic model system, 4394 Selective expression of a plasmid cat gene at a late stage of Bacillus Charge accumulation subtilis sporulation, 3457 Charge accumulation and photochemistry in leaves studied by Inducible expression of a cloned heat shock fusion gene in sea urchin thermoluminescence and delayed light emission, 1107 embryos, 7490 Charge movement Chloride Charge movement in skeletal muscle fibers paralyzed by the calcium- NMR study of chloride ion interactions with thylakoid membranes, 3713 entry blocker D600, 2582 Chloride channel Charge relay system Dimeric structure of single chloride channels from Torpedo Charge state of His-57-Asp-102 couple in a transition state analogue- electroplax, 2772 trypsin complex: A molecular orbital study, 6266 Chloride pump Charge transfer Reconstitution of purified halorhodopsin, 5408 Tunneling in Chromatium chromatophores: Detection of a Hopfield Chlorine-35 NMR charge-transfer band, 135 NMR study of chloride ion interactions with thylakoid membranes, 3713 Chelatin P-Chlornaltrexamine Primary structure and transcription of an amplified genetic locus: The Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum CUP] locus of yeast, 337 myenteric plexus, 7253 Copper metallothionein of yeast, structure of the gene, and regulation of 2-ChIoro-2'-deoxyadenosine expression, 3332 Antileukemic and immunosuppressive activity of 2-chloro-2'- Chelainon deoxyadenosine, 2232 Modulation of cholecystokinin concentrations in the rat hippocampus by Chlorophyll chelation of heavy metals, 5876 Mn2+ and Co2+ toxicity in chlorophyll biosynthesis, 476 Chemical defense Electron nuclear double resonance evidence supporting a monomeric Spider sedation induced by defensive chemicals of milliped prey, 806 nature for P700n in spinach chloroplasts, 1098 Chemical shift Demonstration of transcriptional regulation of specific genes by In vivo nuclear magnetic resonance chemical shift imaging by selective phytochrome action, 1112 irradiation, 6856 Chlorophyll a/b-binding polypeptide Chemoreception Structure and expression of a pea nuclear gene encoding a chlorophyll Membrane proteins unique to vertebrate olfactory cilia: Candidates for a/b-binding polypeptide, 2960 sensory receptor molecules, 1859 Chloroplast Chemotaxis Chloroplast tRNA~lY gene contains a long intron in the D stem: Receptor-mediated activation of a in rabbit neutrophil Nucleotide sequences of tobacco chloroplast genes for tRNAGlY (UCC) plasma membrane, 767 and tRNAAm (UCU), 405 Analysis of the pleiotropic regulation of flagellar and chemotaxis gene Sequence homology and structural similarity between cytochrome b of expression in Caulobacter crescentus by using plasmid mitochondrial complex III and the chloroplast b6-fcomplex: Position of complementation, 1341 the cytochrome b hemes in the membrane, 674 Monitoring of cytosolic free Ca2+ in COa-timulated neutrophils: Loss of Some plant leaves have orientation-dependent EPR and NMR receptor-modulated Ca2+ stores and Ca + uptake in granule-free spectra, 748 cytoplasts, 1416 Electron nuclear double resonance evidence supporting a monomeric cAMP pulses coordinate morphogenetic movement during fruiting body nature for P700' in spinach chloroplasts, 1098 formation of Dictyostelium minutum, 2122 Purification and properties of a pea chloroplast DNA polymerase, 2354 Structure of the Trg protein: Homologies with and differences from other Cooperative transient trapping of photosystem II protons by the integral sensory transducers of Escherichia coli, 3287 membrane portion (CFO) of chloroplast ATP-synthase after mild extraction of the four-subunit catalytic part (CF1), 3078 8058 Biological Sciences Subject Index Proc. NatL. Acad. Sci. USA 81 (1984)

Herbicide resistance in Chlamydomonas reinhardtii results from a Cholesterol side-chain cleavage mutation in the chloroplast gene for the 32-kilodalton protein of Identification and characterization of cDNA clones specific for photosystem II, 3617 cholesterol side-chain cleavage cytochrome P-450, 5628 Modulation of chloroplast movement in the green alga Mougeotia by the pathway Ca2' ionophore A23187 and by calmodulin antagonists, 6368 CholinergicBehavioral and neurochemical differentiation of specific projections in Chloroplast coupling factor the septal-hippocampal cholinergic pathway of the rat, 1880 Partial deglycosylation of chloroplast coupling factor 1 (CF1) prevents the Cholinergic receptor reconstitution of photophosphorylation, 3733 Monoclonal antibodies detect the conservation of muscarinic cholinergic Chloroplast development receptor structure from Drosophila to human brain and detect possible Catabolite repression of chloroplast development in Euglena, 2786 structural homology with a1-adrenergic receptors, 272 Chloroplast DNA Pertussis toxin differentiates between two mechanisms of attenuation of Chloroplast DNA recombination in interspecific hybrids of cyclic AMP accumulation by muscarinic cholinergic receptors, 5680 Chlamydomonas: Linkage between a nonmendelian locus for Chondrocyte streptomycin resistance and restriction fragments coding for 16S Macrophage-derived growth factor for osteoblast-like cells and rRNA, 1164 chondrocytes, 4558 Chloroplast DNA transcripts are encapsidated by tobacco mosaic virus Choreocolar coat protein, 1719 Transfer of nuclei from a parasite to its host, 5420 Extensive and widespread homologies between mitochondrial DNA and Chorion chloroplast DNA in plants, 1946 Molecular cloning of region-specific chorion-encoding RNA The persistence of maternal inheritance in Chlamydomonas despite sequences, 27% hypomethylation of chloroplast DNA induced by inhibitors, 3438 Mutants suppressing in trans chorion gene amplification in Chloroplast gene Drosophila, 3773 Isolation and characterization of a gene for a major light-harvesting Chorion protein polypeptide from Cyanophora paradoxa, 4100 DNA sequence transfer between two high-cysteine chorion gene families Chloroplast membrane in the silkmoth Bombyx mori, 4452 Regulation of protein metabolism: Coupling of photosynthetic electron Chromaffin cell transport to in vivo degradation of the rapidly metabolized 32-kilodalton C6 glioma cell-conditioned medium induces neurite outgrowth and protein of the chloroplast membranes, 1380 survival of rat chromaffin cells in vitro: Comparison with the effects of Membrane protein damage and repair: Selective loss of a quinone-protein nerve growth factor, 2242 function in chloroplast membranes, 4070 Intrinsic GABAergic system of adrenal chromaffin cells, 3218 Chlorpromazine Alternative modes of enkephalin biosynthesis regulation by reserpine and Time-resolved photolabeling by the noncompetitive blocker cyclic AMP in cultured chromaffin cells, 3949 chlorpromazine of the acetylcholine receptor in its transiently open and Facilitation of Caz+-channel currents in bovine adrenal chromaffin closed ion channel conformations, 1897 cells, 5871 Cholecystokinin Chromatin Cytosolic calcium regulates epidermal growth factor endocytosis in rat Specific factor conferring hypersensitivity at the 5' end of the pancreas and cultured fibroblasts, 461 chicken adult ,3-globin gene, 95 Cloning and sequence analysis of a cDNA encoding rat Normal liver chromatin contains a firmly bound and larger protein related preprocholecystokinin, 726 to the principal cytosolic target polypeptide of a hepatic Gastrin and cholecystokinin in pituitary neurons, 1902 carcinogen, 2092 Cloned cDNA to cholecystokinin mRNA predicts an identical Differential DNase I sensitivity of the albumin and a-fetoprotein genes in preprocholecystokinin in pig brain and gut, 4307 chromatin from rat tissues and cell lines, 5031 Modulation of cholecystokinin concentrations in the rat hippocampus by Cytoskeletal involvement in cAMP-induced sensitization of chromatin to chelation of heavy metals, 5876 nuclease in transformed Chinese hamster ovary K1 cells, 5145 Neuropeptide-containing neurons of the cerebral cortex are also Sequence of the bacteriophage SP01 gene coding for transcription factor GABAergic, 6526 1, a viral homologue of the bacterial type II DNA-binding Isolation of a large cholecystokinin precursor from canine brain, 6565 proteins, 7031 Cholera toxin Genetic properties and chromatin structure of the yeast gal regulatory Synthesis of cholera toxin is positively regulated at the transcriptional element: An enhancer-like sequence, 7865 level by toxR, 3471 Chromatium Mechanism of toxin secretion by Vibrio cholerae investigated in strains Tunneling in Chromatium chromatophores: Detection of a Hopfield harboring plasmids that heat-labile enterotoxins of Escherichia charge-transfer band, 135 coli, 7752 Chromatophore Both cholera toxin-induced adenylate cyclase activation and cholera toxin Tunneling in Chromatium chromatophores: Detection of a Hopfield biological activity are inhibited by antibodies against related synthetic charge-transfer band,- 135 peptides, 7893 Chromosome 5a-Cholest-8(14)-en-3f3-ol-15-one DNA polymorphic loci mapped by human 3, 5, 9, 11, 17, Sa-Cholest-8(14)-en-3/-ol-15-one lowers serum cholesterol and induces 18, and 22, 2447 profound changes in the levels of lipoprotein cholesterol and Chromosome 3 apoproteins in monkeys fed a diet of moderate cholesterol Human transferrin: cDNA characterization and chromosomal content, 6861 localization, 2752 Cholesterol Chromosome 4 Increased free cholesterol in plasma low and very low density Linkage disequilibrium and evolutionary relationships of DNA variants lipoproteins in non-insulin-dependent diabetes mellitus: Its role in the (restriction enzyme fragment length polymorphisms) at the serum inhibition of cholesteryl ester transfer, 2512 Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in albumin locus, 3486 familial hypercholesterolemia heterozygotes: Effects on cholesterol Chromosome 5 balance, 2538 Human dihydrofolate reductase gene is located in chromosome 5 and is Intramitochondrial movement of adrenal sterol carrier protein with unlinked to the related , 1484 cholesterol in response to corticotropin, 2970 Chromosome 6 Structure of the cholesteryl ester core of human plasma low density Six HLA-D region a-chain genes on human chromosome 6: lipoproteins: Selective deuteration and neutron small-angle Polymorphisms and associations of DCa-related sequences with DR scattering, 4389 types, 3461 Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex, 4647 Assignment of the gene for methylthioadenosine phosphorylase to human 5a-Cholest-8(14)-en-3/-ol-15-one lowers serum cholesterol and induces chromosome 9 by mouse-human somatic cell hybridization, 2665 profound changes in the levels of lipoprotein cholesterol and Localization of cytochrome P1-450 and P3-450 genes to mouse apoproteins in monkeys fed a diet of moderate cholesterol chromosome 9, 3163 content, 6861 Chromosome 11 Cholesterol biosynthesis Localization of the structural gene for human apolipoprotein A-I on the Divergence in cholesterol biosynthetic rates and 3-hydroxy-3- long arm of human chromosome 11, 508 methylglutaryl-CoA reductase activity as a consequence of granulocyte DNA methylation and regulation of the human P-globin-like genes in versus monocyte-macrophage differentiation in HL-60 cells, 894 mouse erythroleukemia cells containing human chromosome 11, 6618 Modulation of human lymphocyte responses by low density lipoproteins Identification of a recent recombination event within the human /3-globin (LDL): Enhancement but not immunosuppression is mediated by LDL gene cluster, 7875 receptors, 4539 Chromosome 14 Hydroxymethylglutaryl- reductase-containing hepatocytes are The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) distributed periportally in normal and mevinolin-treated rat livers, 5556 translocation involves the immunoglobulin heavy chain locus, 4144 In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A Human c-fos oncogene mapped within chromosomal region 14q21 - reductase, reductase kinase, and reductase kinase kinase by q31, 5826 mevalonolactone, 7293 Chromosome 15 Cholesterol epoxide Hemizygous interstitial deletion of chromosome 15 (band D) in three Cholesterol epoxide is a direct-acting mutagen, 4198 translocation-negative murine plasmacytomas, 1159 Cholesterol ester Increased free cholesterol in plasma low and very low density Human metallothionein genes are clustered in chromosome 16, 5494 lipoproteins in non-insulin-dependent diabetes mellitus: Its role in the Chromosome 17 inhibition of cholesteryl ester transfer, 2512 A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia, 4495 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984) 8059

Chromosome 19 In vitro reprogramming of the photoperiodic clock in an insect brain- Assignment of the human gene for the low density lipoprotein receptor to retrocerebral complex, 5881 chromosome 19: Synteny of a receptor, a ligand, and a genetic Requirement for protein synthesis in the regulation of a circadian rhythm disease, 2826 by serotonin, 7637 Isolation and sequence of a human apolipoprotein CII cDNA clone and Circannual rhythm its use to isolate and map to human chromosome 19 the gene for Rapid recovery of body mass after surgical removal of adipose tissue in apolipoprotein CII, 2945 ground squirrels, 2270 Chromosomal assignment of the gene for human 2, 3158 Circular dichroism Chromosome 20 Kinetic circular dichroism shows that the S-peptide a-helix of Chromosome 20 deletion in human multiple endocrine neoplasia types 2A S unfolds fast and refolds slowly, 7674 and 2B: A double-blind study, 2525 Circumsporozoite Chromosome 21 Circumsporozoite gene of Plasmodium cynomolgi (Gombak): cDNA Receptors for human a and 8 interferon but not for y interferon are cloning and expression of the repetitive circumsporozoite epitope, 7520 specified by human chromosome 21, 5504 Cirrhosis Chromosome abnormality Serum a-fetoprotein levels in human disease: Perspective from a highly Protease inhibitors reduce the frequency of spontaneous chromosome specific monoclonal radioimmunoassay, 3869 abnormalities in cells from patients with Bloom syndrome, 1827 Cistothorus Chromosome conservation Population differences in complexity of a learned skill are correlated with Lengths of chromosomal segments conserved since divergence of man the brain space involved, 6232 and mouse, 814 Citrus exocortis viroid Chromosome deleton Optimal conditions for cell-free synthesis of citrus exocortis viroid and Mice homozygous for chromosomal deletions in the albino locus region the question of specificity of RNA polymerase activity, 4429 lack specific polypeptides in two-dimensional gels, 2132 Cladocera Chromosome evolution Effect of selenium deficiency on cuticle integrity in the Cladocera Lengths of chromosomal segments conserved since divergence of man (Crustacea), 3433 and mouse, 814 Class I antigen Chromosome inactivation Detection of a secreted form of the murine H-2 class I antigen with an Differential methylation of hypoxanthine phosphoribosyltransferase genes antibody against its predicted qarboxyl terminus, 1216 on active and inactive human X chromosomes, 1759 A molecular hybrid of the H-2D1 and H-2Ld genes expressed in the dm1 Chromosome, polytene mutant, 5204 Drosophila DNA topoisomerase I is associated with transcriptionally Allogeneic stimulation of cytotoxic T cells by supported planar active regions of the genome, 6958 membranes, 6159 Chromosome puff Role of a disulfide bridge in the immune function of major Inducible transcription and puffing in Drosophila melanogaster histocompatibility class I antigen as studied by in vitro transformed with hsp7O-phage X hybrid heat shock genes, 5509 mutagenesis, 7544 Chromosome segregation Class I gene DNA topoisomerase II mutant of Saccharomyces cerevisiae: Murine leukemia virus sequences are encoded in the murine major Topoisomerase II is required for segregation of daughter molecules at histocompatibility complex, 1804 the termination of DNA replication, 2616 Class H antigen Chromosome structure Cloning and sequence analysis of the human major histocompatibility Elaboration of telomeres in yeast: Recognition and modification of complex gene DC-3(3, 5199 termini from Oxytricha macronuclear DNA, 1475 Class switch Chromosome translocation Illegitimate recombination generates a class switch from C to C. in an Products of a reciprocal chromosome translocation involving the c-myc IgD-secreting plasmacytoma, 4164 gene in a murine plasmacytoma, 829 Clathrate hydrate The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts Water structure of a hydrophobic protein at atomic resolution: Pentagon the VK locus, 2444 rings of water molecules in crystals of crambin, 6014 The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) Clathrin translocation involves the immunoglobulin heavy chain locus, 4144 Clathrin-coated vesicles from rat liver: Enzymatic profile and Translocation and rearrangement of c-myc into immunoglobulin a heavy characterization of ATP-dependent proton transport, 3108 chain locus in primary cells from acute lymphocytic leukemia, 5514 Cleft palate An 8-kilobase abl RNA transcript in chronic myelogenous leukemia, 5648 Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate Activation of a translocated c-myc gene: Role of structural alterations in glucocorticoid teratogenicity in vitro, 1140 the upstream region, 6798 Clock A 14;18 and an 8;14 chromosome translocation in a cell line derived from In vitro reprogramming of the photoperiodic clock in an insect brain- an acute B-cell leukemia, 7166 retrocerebral complex, 5881 Chromosome walking The molecular clock may be an episodic clock, 8009 Directional cloning of DNA fragments at a large distance from an initial Clock, biological probe: A circularization method, 6812 Molecular genetics of a biological clock in Drosophila, 2142 Chromosome X Clonal deletion Regional localization on the human X chromosome and polymorphism of Cytotoxic T-cell precursors revealed in tolerant 220 the coagulation factor IX gene (hemophilia B locus), 498 neonatally mice, X chromosome-linked muscular dystrophy (mdx) in the mouse, 1189 Clonal population Differential methylation of hypoxanthine phosphoribosyltransferase genes Evidence for clinal population structure in Escherichia coli, 198 on active and inactive human X chromosomes, 1759 Clonal succession Genetic mapping of the human X chromosome by using restriction Monoclonal derivation of mouse myeloid and lymphoid lineages from fragment length polymorphisms, 2836 totipotent hematopoietic stem cells experimentally engrafted in fetal Characterization of a cloned DNA sequence that is present at hosts, 7835 centromeres of all human autosomes and the X chromosome and shows Cloning vector polymorphic variation, 4884 Microinjected pBR322 stimulates cellular DNA synthesis in Swiss 3T3 Cytological mapping of the human glucose-6-phosphate dehydrogenase cells, 400 gene distal to the fragile-X site suggests a high rate of meiotic Clonotype recombination across this site, 7855 Purification and NH2-terminal amino acid sequencing of the ,3 subunit of Chromosome X inactivation a human T-cell antigen receptor, 3851 Methylation of the hypoxanthine phosphoribosyltransferase locus on the Clostium human X chromosome: Implications for X-chromosome Role of carbon monoxide dehydrogenase in the autotrophic pathway used inactivation, 2806 by acetogenic bacteria, 6261 Chromosome Y Coat protein Lampbrush loop-specific protein of Drosophila hydei, 3404 Major coat protein and single-stranded DNA-binding protein of Chromsome translocation filamentous virus Pf3, 699 Induction of plasmacytoid differentiation by phorbol ester in B-cell Coated pit lymphoma cell lines bearing 8;14 translocations, 3547 Morphologic characterization of the pathway of transferrin endocytosis Chronic myelogenous leukemia and recycling in human KB cells, 175 An 8-kilobase abl RNA transcript in chronic myelogenous leukemia, 5648 Down-regulation of the epidermal growth factor receptor in KB cells is Chylomicron due to receptor internalization and subsequent degradation in Liver uptake of chylomicron remnants with high and low apoprotein E:C , 2384 ratios, 5863 Coated vesicle Cigarette smoke Neuronal growth cones: Specific interactions mediated by filopodial Adenosine strongly potentiates pressor responses to nicotine in rats, 5599 insertion and induction of coated vesicles, 1849 Ciliary ganglion neuron Clathrin-coated vesicles from rat liver: Enzymatic profile and Shared antigenic determinant between the Electrophorus acetylcholine characterization of ATP-dependent proton transport, 3108 receptor and a synaptic component on chicken ciliary ganglion Accumulation of coated vesicles bearing mannose 6-phosphate receptors neurons, 3223 for lysosomal enzymes in the Golgi region of I-cell fibroblasts, 5135 Cobalt Circadian rhythm , 2 RU 486: A steroid with antiglucocorticosteroid that MnC + and Co2+ toxicity in chlorophyll biosynthesis, 476 activity only Recognition of the muscarinic receptor by its endogenous disinhibits the human pituitary-adrenal system at a specific time of neurotransmitter: Binding of [3Hlacetylcholine and its modulation by day, 3879 transition metal ions and guanine nucleotides, 3650 8060 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

Codon-anticodon interaction Monitoring of cytosolic free Ca2+ in C5a- timulated neutrophils: Loss of Mlecular model of ribosome frameshifting, 5797 receptor-modulated Ca2+ stores and Ca + uptake in granule-free Coenzyme binding cytoplasts, 1416 Human liver alcohol dehydrogenase: Amino acid substitution in the P2 2 Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor Oriental isozyme explains functional properties, establishes an active CR2, 4510 site structure, and parallels mutational exchanges in the yeast Genes for murine fourth complement component (C4) and sex-limited enzyme, 3024 protein (Slp) identified by hybridization to C4- and Slp-specific Colchicine cDNA, 4908 Tubulins from different higher plant species are immunologically Isolation of cDNA clones specifying the fourth component of mouse nonidentical and bind colchicine differentially, 1440 complement and its isotype, sex-limited protein, 6822 Imbalance of total cellular nucleotide pools and mechanism of the Nucleotide sequence of cDNA and derived amino acid sequence of colchicine-induced cell activation, 2401 human complement component C9, 7298 Cold sensitivity Evidence for linkage between the loci coding for the binding protein for Transformation properties of type 5 adenovirus mutants that differentially the fourth component of human complement (C4BP) and for the C3b/ express the ElA gene products, 5734 C4b receptor, 7890 Collagen Complement receptor Structural analysis of fibronectin and its collagen-binding fragment from Evidence for linkage between the loci coding for the binding protein for several cell lines, 28 the fourth component of human complement (C4BP) and for the C3b/ von Willebrand protein binds to extracellular matrices independently of C4b receptor, 7890 collagen, 471 Complementarity-determining region Accelerated age-related browning of human collagen in diabetes Rearranged immunoglobulin heavy chain variable region (VH) mellitus, 583 that deletes the second complementarity-determining region, 5194 Endonuclease Si-sensitive site in chicken pro-a2(I) collagen 5' flanking Complementary DNA gene region, 1659 See cDNA Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of Complementation bovine osteogenesis imperfecta, 2213 Location of amino acid alterations in mutants of aspartate Organization of collagen types I and V in the embryonic chicken cornea: transcarbamoylase: Structural aspects of interallelic Monoclonal antibody studies, 2791 complementation, 115 Synthesis and characterization of cDNA encoding a cartilage-specific Interallelic complementation in an inborn error of metabolism: Genetic short collagen, 3014 heterogeneity in argininosuccinate lyase deficiency, 4480 Cathepsin D-mediated processing of procollagen: Lysosomal enzyme Transient complementation of xeroderma pigmentosum cells by involvement in secretory processing of procollagen, 3302 microinjection of poly(A)+ RNA, 5676 Goodpasture antigen of the glomerular basement membrane: Localization Computation, biolo -cal to noncollagenous regions of type IV collagen, 3838 Understanding biological computation: Reliable learning and Rapid purification of a cloned gene product by genetic fusion and site- recognition, 6871 specific proteolysis, 4692 Computer simulation Detection of cis and trans X-Pro peptide bonds in proteins by 13C NMR: A consistent picture of protein dynamics, 7088 Application to collagen, 4800 Concanavalin A Monoclonal antibodies to human type IV collagen: Useful reagents to Isolation and partial characterization of concanavalin A receptors on demonstrate the heterotrimeric nature of the molecule, 7343 cloned cytotoxic T lymphocytes, 1519 Collagen gene Insertion of retrovirus into the first intron of a1(I) collagen gene leads to Conditioned medium embryonic lethal mutation in mice, 1504 Isolation of immortal cell lines from the first stage of murine leukemia Synthesis and characterization of cDNA encoding a cartilage-specific virus-induced leukemia, 5464 short collagen, 3014 Conditioned stimulus mapping of a homozygous mutation in the carboxyl- Tonically discharging putamen neurons exhibit set-dependent propeptide-coding region of the proa2(I) collagen gene in a patient with responses, 4998 osteogenesis imperfecta, 4524 Conditioning Collagen metabolism Classical conditioning of the rabbit eyelid response increases glutamate Abnormal collagen metabolism in cultured skin fibroblasts from patients receptor binding in hippocampal synaptic membranes, 2548 with Duchenne muscular dystrophy, 5130 Branch-specific heterosynaptic facilitation in Aplysia siphon sensory Collagenase cells, 2577 Isolation of a collagenase cDNA clone and measurement of changing Confluence collagenase mRNA levels during induction of rabbit synovial Perpendicular orientation and directional migration of amphibian neural fibroblasts, 1981 crest cells in dc electrical fields, 160 Organization of collagen types I and V in the embryonic chicken cornea: Conformational analysis Monoclonal antibody studies, 2791 Conformational analysis of 6-cis- and 6-trans-leukotriene B4-calcium CoUetotrichum complexes, 3370 Differential induction of chalcone synthase mRNA activity at the onset of Congenital defect phytoalexin accumulation in compatible and incompatible plant- Failure to demonstrate mutations affecting protein structure or function in pathogen interactions, 3384 children with congenital defects or born prematurely, 5499 Collision coupling Conjugation Stimulatory GTP regulatory unit N and the catalytic unit of adenylate Construction of shuttle vectors capable of conjugative transfer from cyclase are tightly associated: Mechanistic consequences, 6579 Escherichia coli to nitrogen-fixing filamentous cyanobacteria, 1561 Collision frequency Plasmid transfer from Escherichia coli to Bacteroides fragilis: Differential Relationship between lateral diffusion, collision frequency, and electron expression of antibiotic resistance phenotypes, 7203 transfer of mitochondrial inner membrane oxidation-reduction Conjunctor cell components, 2606 Transfer of nuclei from a parasite to its host, 5420 Colon Aberrant expression of an amplified c-myb oncogene in two cell lines Structure of the 5' ends of immunoglobulin genes: A novel conserved from a colon carcinoma, 4534 sequence, 2650 Monoclonal antibodies of predefined specificity detect activated ras gene Constant region expression in human mammary and colon carcinomas, 5227 Chimeric human antibody molecules: Mouse antigen-binding domains Colony-forming unit with human constant region domains, 6851 Mouse yolk sac and intraembryonic tissues produce factors able to elicit Contractile protein differentiation of erythroid burst-forming units and colony-forming Application of the Dale-Eisinger analysis to proximity mapping in the units, respectively, 1453 contractile system, 3723 Colony-stimulating factor Contractility Stimulation of human granulocyte function by monoclonal antibody Crystallization of myosin subfragment 1, 4378 WEM-G1, 1818 Contraction Binding of the differentiation-inducer, granulocyte-colony-stimulating Calcium-binding protein, parvalbumin, is reduced in mutant mammalian factor, to responsive but not unresponsive leukemic cell lines, 3765 njuscle with abnormal contractile properties, 4814 Colony-stimulating factor (CSF) controls proliferation of CSF-dependent Ca1+ causes active contraction of bile canaliculi: Direct evidence from cells by acting during the G1 phase of the cell cycle, 7451 microinjection studies, 6164 Commitment Controlled release Inducer-mediated commitment of murine erythroleukemia cells to Long-acting delivery systems for peptides: Inhibition of rat prostate terminal cell division: The expression of commitment, 3394 tumors by controlled release of [D-Trp6]luteinizing hormone-releasing Compartmentation hormone from injectable microcapsules, 5845 Compartmental distribution of striatal cell bodies expressing "Convertible pore" model [Metlenkephalin-like immunoreactivity, 7980 A 'convertible pore" model of neural membrane conductance, 7238 Competition Convolution Body 'size and food size in freshwater zooplankton, 6427 Sharpening radiographs, 5237 Complement Coomassle blue Identification of a 145,000 Mr membrane protein as the C3d receptor Detection of erythrocyte membrane proteins, sialoglycoproteins, and (CR2) of human B lymphocytes, 881 lipids in the same polyacrylamide gel using a double-staining Isolation of cDNA clones for human complement component C2, 1212 technique, 1733 Biological Sciences Subject Index Proc. NatL Acad ScL USA 81 (1984) 8061

Cooperativity Coupling factor B A quantitative model for the cooperative mechanism of human Evidence for the involvement of coupling factor B in the H' channel of hemoglobin, 1093 the mitochondrial H+-ATPase, 1371 Copper Courtship Secondary structure specificity of the nuclease activity of the 1,10- Artificial selection for a secondary sexual character in males of phenanthroline-copper complex, 3 Drosophila silvestris from Hawaii, 3915 Primary structure and transcription of an amplified genetic locus: The Cowpea mosaic virus CUP] locus of yeast, 337 Purification of cowpea mosaic virus RNA replication complex: Single-chain structure of human ceruloplasmin: The complete amino acid Identification of a virus-encoded 110,000-dalton polypeptide responsible sequence of the whole molecule, 390 for RNA chain elongation, 1951 Effects of Cu deficiency on photosynthetic electron transport, 2369 Cowpox vir Bis[cyclo(histidylhistidine)]copper(II) complex that mimicks the active Spontaneous deletions and duplications of sequences in the genome of center of superoxide dismutase has its catalytic activity, 3283 cowpox virus, 6817 Copper metallothionein of yeast, structure of the gene, and regulation of expression, 3332 CRI sequence Structural model of human ceruloplasmin based on internal triplication, Genomic structure and possible retroviral origin of the chicken CRI hydrophilic/hydrophobic character, and secondary structure of repetitive DNA sequence family, 6667 domains, 4761 Crambin A ligand-specific action of chelated copper on hypothalamic neurons: Crambin in phospholipid vesicles: Circular dichroism analysis of crystal Stimulation of the release of luteinizing hormone-releasing hormone structure relevance, 1406 from median eminence explants, 7656 Water structure of a hydrophobic protein at atomic resolution: Pentagon Coral rings of water molecules in crystals of crambin, 6014 Water flow and coral colony size: Interhabitat comparisons of the cte protein octocoral Alcyonium siderium, 5473 Interaction of the bacteriophage P1 recombinase Cre with the Core enhancer recombining site loxP, 1026 Preferential binding of estrogen-receptor complex to a region containing Creatine kinase the estrogen-dependent hypomethylation site preceding the chicken Creatine kinase protein sequence encoded by a cDNA made from vitellogenin II gene, 429 Torpedo californica electric organ mRNA, 7007 Cornea Complete nucleotide sequence of Torpedo marmorata mRNA coding for Organization of collagen types I and V in the embryonic chicken cornea: the 43,000-dalton v2 protein: Muscle-specific creatine kinase, 7313 Monoclonal antibody studies, 2791 Cromolyn Coronary perfusion The cromolyn binding protein constitutes the Ca2' channel of basophils Enhanced oxygen unloading by an interdimerically crosslinked opening upon immunological stimulus, 6841 hemoglobin in an isolate4 perfused rabbit heart, 2941 Cross-bridge Coronavirus Calculation of the polarized fluorescence from a labeled muscle fiber, 145 Assembly in vitro of a spanning membrane protein of the endoplasmic X-ray evidence for two structural states of the actomyosin cross-bridge in reticulum: The El glycoprotein of coronavirus mouse hepatitis virus muscle fibers, 2364 A59, 1421 Cross-reacting material Corpora cardiaca Cross-reacting material in Gaucher disease fibroblasts, 6506 Isolation and primary structure of two peptides with cardioacceleratory Cross-reaction and hyperglycemic activity from the corpora cardiaca of Periplaneta Cross-reactions of polysaccharides of fungi, molds, and yeasts in anti- americana, 5575 pneumococcal and other antisera, 5247 Corrinoid Cross-reactivity Methyl transfer from methylcobalamin to diaquocobinamide, 2698 Serological cross-reactivity between envelope gene products of type I and Role of carbon monoxide dehydrogenase in the autotrophic pathway used type II human T-cell leukemia virus, 7579 by acetogenic bacteria, 6261 Crossin-over Cortical collecting tubule Identification of a recent recombination event within the human P-globin Single channel recordings of calcium-activated potassium channels in the gene cluster, 7875 apical membrane of rabbit cortical collecting tubules, 4237 Cro."-zover, unequal Cortkiapinal neuron A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 Subcortical projections from ectopic neocortical neurons, 964 mutant, 5204 Corticosterone Multiple gene deletions within the human immunoglobulin heavy-chain Glucocorticoid-sensitive hippocampal neurons are involved in terminating cluster, 5811 the adrenocortical stress response, 6174 Crosslinking reagent Corticotropin I-labeled crosslinking reagent that is hydrophilic, photoactivatable, and Intramitochondrial movement of adrenal sterol carrier protein with cleavable through an azo linkage, 5286 cholesterol in response to corticotropin, 2970 Crown gall Identification and characterization of cDNA clones specific for Crown gall oncogenesis: Evidence that a T-DNA gene from the cholesterol side-chain cleavage cytochrome P-450, 5628 Agrobacterium Ti plasmid pTiA6 encodes an enzyme that catalyzes Corticotropin-releasing factor synthesis of indoleacetic acid, 5071 Corticotropin-releasing factor-immunoreactive neurons of the T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin paraventricular nucleus become vasopressin positive after biosynthesis, 5994 adrenalectomy, 1854 Nucleotide sequence of the insertion sequence found in the T-DNA Co-expression of corticotropin-releasing factor and vasopressin region of mutant Ti plasmid pTiA66 and distribution of its homologues immunoreactivity in parvocellular neurosecretory neurons of the in octopine Ti plasmid, 7495 adrenalectomized rat, 1883 Crustacea Properties of rat anterior pituitary vasopressin receptors: Relation to Effect of selenium deficiency on cuticle integrity in the Cladocera adenylate cyclase and the effect of corticotropin-releasing factor, 2907 (Crustacea), 3433 Cos-1 cell Cryo-ultramicrotomy Processing of complex DNA heteroduplexes in Escherichia coli and Cos-1 An improved procedure for immunoelectron microscopy: Ultrathin plastic monkey cells, 5792 embedding of immunolabeled ultrathin frozen sections, 5744 Cosmid Cryospectokinetic study Novel cluster of a-interferon gene sequences in a placental cosmid DNA Cryospectrokinetic characterization of intermediates in biochemical library, 2435 reactions: Carboxypeptidase A, 5041 Selective isolation of cosmid clones by homologous recombination in Crystal structure Escherichia coli, 4129 Crambin in phospholipid vesicles: Circular dichroism analysis of crystal Cosmid shuttle vector structure relevance, 1406 Direct isolation of the functional human thymidine kinase gene with a Crystaint cosmid shuttle vector, 414 Direct observation of S-crystallin accumulation by laser light-scattering Cotransational insertion spectroscopy in the chicken embryo lens, 785 Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an Sequence of a complete chicken 6-crystallin cDNA, 2611 integral glycoprotein of the , 1674 Nondisulfide polymerization of -- and P-crystallins in the human Cotransmitter lens, 2878 A cDNA clone encoding neuropeptides isolated from Aplysia neuron Lens selects specific P-crystallin sequences as Lii, 4988 substrate, 7017 Cotyledon r-Crystallin family of the mouse lens: Structural and evolutionary Maturation of catalase precursor proceeds to a different extent in relationships, 7762 glyoxysomes and leaf peroxisomes of pumpkin cotyledons, 4809 Culture -Electrical polarity in embryos of wild carrot precedes cotyledon Cultural and biological evolutionary processes: Gene-culture differentiation, 6064 disequilibrium, 1604 4-Coumarate:CoA lgase Culture medium, protein-free Induction of ammonia-lyase and 4-coumarate:CoA Long-term cultivation and differentiation of human erythroleukemia cells mRNAs in cultured plant cells by UV light or fungal elicitor, 1102 in a protein-free chemically defined medium, 453 Coupling factor Current, singchannel acid bovine heart factor 6603 Acetyicholine receptor (from Electrophorus electricus): A comparison of Amino sequence of coupling 6, single-channel current recordings and chemical kinetic measurements, 5281 8062 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984)

Cuticle Cyclobutane dimer Effect of selenium deficiency on cuticle integrity in the Cladocera Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from (Crustacea), 3433 Escherichia coli DNA requires the uvrA, uvrB, and urvC gene Cutinase products, 3821 Cloning and structure determination of cDNA for cutinase, an enzyme Cycloheximide involved in fungal penetration of plants, 3939 Specific stimulation of actin gene transcription by epidermal growth Cyanide factor and cycloheximide, 7476 Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic Cyclosporin A acid during its conversion to ethylene, 3059 Cyclosporin A inhibits T-cell growth factor gene expression at the level of Iron-carbon bond lengths in carbonmonoxy and cyanomet complexes of mRNA transcription, 5214 the monomeric hemoglobin III from Chironomus thummi thummi: A Cydosporine critical comparison between resonance Raman and x-ray diffraction Transplantation of human or rodent tumors into cyclosporine-treated studies, 5106 mice: A feasible model for studies of tumor biology and Cyanidum chemotherapy, 7927 Isolation and characterization of a gene for a major light-harvesting Cysteine polypeptide from Cyanophora paradoxa, 4100 The presence of cysteine in the cytoplasmic domain of the vesicular f-Cyanoalanine stomatitis virus glycoprotein is required for palmitate addition, 2050 Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic Structures of cysteine-containing peptides in isosafrole-inducible rat acid during its conversion to ethylene, 3059 hepatic microsomal cytochrome P450d: Sequence homology with 3- Cyanobacteria methylcholanthrene-induced cytochrome P-450c, 4298 Construction of shuttle vectors capable of conjugative transfer from Vaccinia virus 19-kilodalton protein: Relationship to several mammalian Escherichia coli to nitrogen-fixing filamentous cyanobacteria, 1561 proteins, including two growth factors, 7363 Nucleotide sequence of a multiple-copy gene for the B protein of Cytochalasin B photosystem II of a cyanobacterium, 2693 Monitoring fibroblast behavior in tissue culture with an applied electric Cloning and sequencing of the genes encoding the a and f3 subunits of C- field, 3761 phycocyanin from the cyanobacterium Agmenellum Identification and characterization of the glucose transporter of the quadruplicatum, 6983 blood-brain barrier by cytochalasin B binding and immunological Genes for the a and (3 subunits of phycocyanin, 7946 reactivity, 7233 Cyanoformic add Cytochrome b Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxyli. Sequence homology and structural similarity between cytochrome b of acid during its conversion to ethylene, 3059 mitochondrial complex III and the chloroplast b5-f complex: Position of Cyanogen bromide peptide mapping the cytochrome b helnes in the membrane, 674 Structural analysis of human adult and fetal alkaline phosphatases by Cytochrome c' cyanogen bromide peptide mapping, 6120 Tunneling in Chrongtium chromatophores: Detection of a Hopfield Cyanophora charge-transfer band, 135 Isolation and characterization of a gene for a major light-harvesting Single catalytic site model for the oxiolatipn of ferrocytochrome c by polypeptide from Cyanophora paradoxa, 4100 mitochondrial cytoehrome c oxidase, 347 Cyclic AMP Kinetics of electron transfer between cardiac cytochromes cl and c, 2026 Isolation and characterization of the rat tyrosine aminotransferase Differential regulation of the duplicated isocytochrome c genes in gene, 1346 yeast, 4475 cAMP pulses coordinate morphogenetic movement during fruiting body Cytochrome c oiddae formation of Dictyostelium minutum, 2122 Single catalytic site model for the oxidation of ferrocytochrome c by Differential cellular distribution of cAMP-dependent protein kinase during mitochondrial cytodhroie c oxidase, 347 development of Diciyostelium discoideum, 2127 Isolation and characterization of a cDNA clone for bovine cytochrome c Evidence for parallel actions of a molluscan neuropeptide and serotonin oxidase subunit IV, 6295 in mediating arousal in Aplysia, 2934 Cytochrome Godase Antagonism by taxof of effects of microtubule-disrupting agents on Steps in processing of the mitochondrial cytoehrome oxidase subunit I lymphocyte cAMP metabolism and cell function, 34% pre-mRNA affected by a nuclear mutation ip yqast, 8 Alternative modes of enkephalin biosynthesis regulation by reserpine and Cytochrome P450 cyclic AMP in cultured chromaffin cells, 3949 N-Acetyl-p-benzoquinone imine: A cytochrome P450-mediated oxidation Potentiation of a1-adrenergic responses in rat liver by a QAMP-dependent product' of acetaminophen, 1327 mechanism, 4208 Coding nucleotide sequence of 3-methylcholanthrene-inducible Monoclonal antibodies to purified muscarinic receptor display agonist-like -- cytochrome P-450d cDNA from rat liver, 1649' activity, 4331 Camphor hydroxylase of Pseudomonas putida:` Vestiges of sequence In vivo, cAMP stimulates growth and morphogenesis of mouse mammary homology in cytochrome P450CAM, putidareloxin, and related ducts, 4950 proteins, 1664 Adenosine-dependent activation of tyrosine hydroxylasq is defective in Mutagenicity of quinones: Pathways of metabolij activation and adenosine kinase-deficient PC12 cells, 4974 detoxification, 1696 Cytoskeletal involvement in cAMP-induced sensitization of chromatin to Cloning and expression of cDNA encoding a bovine adrenal nuclease digestion in transformed Chinesq hamster ovary K1 cells, 5145 P450 specific for steroid 21-hydroxylation, 1986' cytochromqe Pertussis toxin differentiates between two mechanisms of attenuation of Localization of cytochroipe P1450 and P3450 to mouse cyclic AMP accumulation by muscarirlic cholinergic receptors, 5680 chromosome 9, 3163 §&es Determination of synaptic phenotype: Insulin and cAMP independently Signal recognition particle is required for co-translational insertion of initiate development of electrotonic coupling between cultured cytochrome P450 into miprosomal membranes, 3361 sympathetic neurons, 6235 On the amino acid sequente of cytochrome P-450 isozyme 4 from rabbit Transcriptional activation of the rat liver tyrosine pminotransferase gene liver microsomes, 4260 by cAMP, 6637 Structures of cysteine-containing peptides in isosafrole-inducible rat High-affinity binding of the regulatory subunit (R ) of cAMP-dependent hepatic microsomal cytoqhrome P450d: Sequente homology with 3- protein kinase to microtubule-ass6ciated and ot'Aer cellular methylcholanthrene-induced cytochrome 4298 proteins, 6723 Molecular cloning and nucleotide sequence P-110c,of clNA for mRNA of Two endogenous neuropeptides mqdulate the gill and siphon withdrawal mitochondrial cytochrome P450(SCC) of boyine adrenal cortex, 4647 reflex in Aplysia by presynaptip facilitation involving cAMP-dependent Distinct organization of methylcholanthrene- and phenobarbital-inducible closure of a serotonin-sensitive potassium chapnel, 7956 cytochrome P450 genes in the rat, 5066 Cyclic AMP receptor Identification and characterization of cDNA clones specific for Regulation of the araC gene of Escherichia coli: Catabolite repression, cholesterol side-chain pleavage cytochrome P45p, 5628 autoregulation, and effect of araBAD expression, 4120 Characterization 'of a human liver cytochrome P450 involved in the Cyclic AMP receptor protein oxidation of debrisoquine and other drugs by using antibodies raised to Molecular basis of DNA sequence recognition by the catabolite gene the analogous rat enzyme, 7348 activator protein: Detailed inferences from three mutations that alter HLA-linked congenital adrenal hyperplasia results from a defective gene DNA sequence specificity, 7274 encodipg a cytochrome.P-450 specific for steroid 21- Cyclic GMP hydrpxylation, 7505 Neurotransmitter receptors mediate cyclic GMP formation by Cytokeeptin involvement of arachidonic acid and lipoxygenase, 3905 Association of cytokeratin p39 with DNA in intact Novikoff hepatoma Monoclonal antibodies to purified muscarinic receptor display agonist-like cells, 419 ' activity, 4331 Developmentjsl regulation of cytokeratins in cells pf the rat mammary Cyclic GMP may serve as a second messenger in peptide-induced muscle gladd studied with monoclpnal antibodies, 1203 degeneration in an insect, 6718 Cytoidnip Atrial natriuretic factor elicits an endothelium-independent relaxation and Identification of a cloned cytokinin biosynthetic gene, 4776 activates particulate guanylate cyclase in vascular smooth muscle, 7661 T-DNA of Agrobacterium lumefaciens encodes an enzyme of cytokinin Cyclic nucleotide biosynthesis, 5994 Calcium-dependent, cyclic nucleotide-independent steroidogenesis in the Cytolysin bovine placenta, 6403 Liposomes as targets for granule cytolysin from cytotoxic large granular Cyclin lymphocyte tumors, 5551 Expression of the transformation-sensitive protein "cyclin" in normal Cytolysis human epidermal basal cells and simian virus 40-transformed Antagonism by taxol of effeqts of microtubule-disrupting agents on keratinocytes, 3128 lymphocyte cAMP metabolism and cell function, 3496 Epidermal growth factor inhibits the synthesis of the nuclear protein Tumors undergoing rejection induced by monoclonal antibodies of the cyclin in A431 human carcinoma cells, 4848 IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis, 3506 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984) 8063

A species of human a interferon that lacks the ability to boost human Daudi cell natural killer activity, 4926 Selective reduction of c-myc mRNA in Daudi cells by human X Selective destruction of a host blood cell type by a parasitoid wasp, 6154 interferon, 1747 Attachment of an anti-receptor antibody to non-target cells renders them Dauer larva susceptible to lysis by a clone of cytotoxic T lymphocytes, 7922 A pheromone-induced developmental switch in Caenorhabditis elegans: Cytomegalovirus Temperature-sensitive mutants reveal a wild-type temperature- Promoter-regulatory region of the major immediate early gene of human dependent process, 819 cytomegalovirus, 659 DC antigen Murine monoclonal antibody to a single protein neutralizes the infectivity Cloning and sequence analysis of the human major histocompatibility of human cytomegalovirus, 876 complex gene DC-33, 5199 Cloning and physical mapping of a gene fragment coding for a 64- 3-Deazaadenosine kilodalton major late antigen of human cytomegalovirus, 4965 Differentiation of myoblast cell lines and biological methylation: 3- Cytomegalovirus infects human lymphocytes and monocytes: Virus Deazaadenosine stimulates formation of multinucleated myofibers, 3064 expression is restricted to immediate-early gene products, 6134 Debrisoquine Cytoplasm Characterization of a human liver cytochrome P-450 involved in the Diffusion of a small molecule in the cytoplasm of mammalian cells, 3414 oxidation of debrisoquine and other drugs by using antibodies raised to The translational mobility of substances within the cytoplasmic the analogous rat enzyme, 7348 matrix, 6747 Decarbonylation Cytosine transport Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a Photoaffinity labeling and characterization of the cloned purine-cytosine particulate preparation from Pisum sativum, 6613 transport system in Saccharomyces cerevisiae, 6276 Deer mouse Cytoskeleton Biochemical and physiological correlates of deer mouse a-chain Monoclonal antibodies detect a spectrin-like protein in normal and hemoglobin polymorphisms, 5484 dystrophic human skeletal muscle, 776 Dehydration Lysosomes are associated with microtubules and not with intermediate filaments in cultured fibroblasts, 788 Lamellar-to-hexogonalti phase transitions in the plasma membrane of Intermediate filaments in monkey kidney TC7 cells: Focal centers and isolated protoplasts after freeze-induced dehydration, 6373 interrelationship with other 1117 Deletion cytoskeletal systems, Proviral deletions and oncogene base-substitutions in insertionally Ca2+-ATPase of the sarcoplasmic reticulum shares a conlmoh domain mutagenized c-myc alleles may contribute to the progression of avian with a membrane glycoprotein associated with the cyloskeleton of bursal tumors, 843 micrdilli, 1130 The [poky] mutant of Neurospora contains a 4-base-pair deletion at the 5' Identification of glial filament protein and vimentin in the same end of the mitochondrial small rRNA, 3791 1intermediate filament system in human glioma cells, 2102 Spontaneous and mutagen-induced deletions: Mechanistic studies in Dliffusion of a small molecule in the cytoplasm of mammalian cells, 3414 Salmonella tester strain TA102, 4457 Titin is an extraordinarily long, flexible, and slender myofibrillar Generation of deletions in pneumococcal mal genes cloned in Bacillus protein, 3685 subtilis, 5189 Tumor promoters induce a specific morphological signature in the nuclear Multiple gene deletions within the human immunoglobulin heavy-chain matrix-intermediate filament scaffold of Madin-Darby canine kidney cluster, 5811 (MDCK) cell colonies, 4409 mu-2: Mutator gene in Drosophila that potentiates the induction of Cytoskeletal involvement in cAMP-induced sensitization of chromatin to terminal deficiencies, 6090 nuclease digestion in transformed Chinese hamster ovary K1 cells, 5145 Spontaneous deletions and duplications of sequences in the genome of Intermediate filament cDNAs from BHK-21 cells: Denlonstration of cowpox virus, 6817 distinct genes for desmin and vimentin in all vertebrate classes, 5970 Lens transglutaminase selects specific p-crystallin sequences as Deletion, interstitial substrate, 7017 Hemizygous interstitial deletion of chromosome 15 (band D) in three Cytotoxic antibody translocation-negative murine plasmacytomas, 1159 Appearance of cytotoxic antibody to viral gp7O on feline lymHplioma cells Deletion mapping (FL-74) in cats during ex vivo imnlunoadsorption therapy: Quantitation, Mapping of the late promoter of simian virus 40, 23 characterization, and association with remission of disease and Deletion mutagenesis disappearance of viremia, 3516 Structural intermediates of deletion mutagenesis: A role for palindromic Cytotoxic T lymphocyte DNA, 512 Immunoprecipitation of cell surface structures of cloned cytotoxic T Deletion mutant lymphocytes by clone-specific antisera, 573 Determination of the promoter region of mouse ribosomal RNA gene by Isolation and partial characterization of concanavalin A receptors on an in vitro transcription system, 299 cloned cytotoxic T lymphocytes, 1519 Determination of the promoter region of mouse ribosomal RNA gene by Monoclonal antibodies specific for a murine cytotoxic T-lymphocyte an in vitro transcription system (Correction), 2587 clone, 1799 8 agent Allogeneic stimulation of cytotoxic T cells by supported planar Transmission of the -associated 8 agent to the eastern membranes, 6159 woodchuck, 2208 Protection from rabies by a vaccinia virus recombinant containing the Delta-sleep-inducing peptide rabies virus glycoprotein gene, 7194 Differential sleep-promoting effects of five sleep substances nocturnally Recogdition of HLA-A2 and -B7 antigens by cloned tytdtoxic T infused in unrestrained rats, 6240 Iylnphocytes after gene transfer into human and monkey, but not Dendritic cell mouse, cells, 7549 Prevention of rejection of murine islet allografts by pretreatment with Attachment of an anti-receptor antibody to non-target cells renders them anti-dendritic cell antibody, 3864 susceptible to lysis by a clone of cytotoxic T lymphocytes, 7922 Dendritic field Cytotoxlc T-lymphocyte precursor Numbers of specific types of neuron in layer IVab of cat striate Cytotoxic T-cell precursors revealed in neonatally tolerant mice, 220 cortex, 3898 Cytotoxicity Dendroica Adaptive response in mammalian cells: Crossreactivity of different Neophobia in the foraging-site selection of a neotropical migrant bird: An pretreatments of cytotoxicity as contrasted to mutagenicity, 1062 experimental study, 3778 T-cell-mediated cytotoxicity against autologous malignant melanoma: Denervation Analysis with interleukin 2-dependent T-cell cultures 3511 Changes in rat adrenal catecholamines and proenkephalin metabolism Identification and characterization of a monoclonal antibody to an antigen after denervation, 3587 expressed on activated macrophages, 4505 Denervation of rat adrenal glands markedly increases preproenkephalin Liposomes as targets for granule cytolysin from cytotoxic large granular mRNA, 7221 lymphocyte tumors, 5551 9-Deoxy-A_,A'2-13,14-dihydroprostaglandin D2 Cytotoxin 9-Deoxy-A9,Al2-13,14-dihydroprostaglandin D2, a metabolite of Necrosin: Purification and properties of a cytotoxin derived from a prostaglandin D2 formed in human plasma, 1317 mirine macrophage-like cell line, 7932 6-Deoxyacyclovir 6-Deoxyacyclovir: A xanthine oxidase-activated prodrug of Dale-Eisinger analysis acyclovir, 3209 Application of the Dale-Eisinger analysis to proximity mapping in the Deoxyadenosine contractile system, 3723 Antileukemic and immunosuppressive activity of 2-chloro-2'- Dansyl-L-argininal deoxyadenosine, 2232 Tumor cell proteinase visualization and quantification using a fluorescent 2'-Deoxycoformycin transition-state analog probe, 1135 Conversion of a stem ceil leukemia from a T-lymphoid to a myeloid Daphnia phenotype induced by the adenosine deaminase inhibitor 2'- Effect of selenium deficiency on cuticle integrity in the Cladocera deoxycoformycin, 253 (Crustacea), 3433 Deoxyglucose Dark-field electron microscopy Changes in local cerebral glucose utilization during rewarding brain Radial distributions of density within macromolecular complexes stimulation, 635 determined from dark-field electron micrographs, 6363 20-Deoxymakisterone A Daucus Evidence for the presence of makisterone A in Drosophila larvae and the Electrical polarity in embryos of wild carrot precedes cotyledon secretion of 20-deoxymakisterone A by the ring gland, 5643 differentiation, 6064 Secondary structure specificity of the nuclease activity of the 1,10- phenanthroline-copper complex, 3 8064 Biological Sciences Subject Index Proc. NatL Acad Sd USA 81 (1984)

Tubular arrays of the actin-DNase I complex induced by pl,P4-Di(adenosine-S')-tetraphosphate gadolinium, 1669 991Tc-labeled nucleotides as tumor-seeking radiodiagnostic agents, 918 Differential DNase I sensitivity of the albumin and a-fetoprotein genes in chromatin from rat tissues and cell lines, 5031 2,6-Diamlnopimelic acid Cytoskeletal involvement in cAMP-induced sensitization of chromatin to Molecular model for elongation of the murein sacculus of Escherichia nuclease digestion in transformed Chinese hamster ovary K1 cells, 5145 coli, 1844 - cis-Diamminedichloroplatinum Mapping of DNase I-hypersensitive sites in the upstream DNA of human Transplantation of human or rodent tumors into cyclosporine-treated embryonic E-globin gene in K562 leukemia cells, 2718 mice: A feasible model for studies of tumor biology and Deoxyribonucleotidase chemotherapy, 7927 Identification of thymidine and deoxyribonucleotidase Diapause activities among normal of 5'-nucleotidase in human In vitro reprogramming of the photoperiodic clock in an insect brain- erythrocytes, 588 retrocerebral complex, 5881 Depsipeptide Diaquocobinamide P-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl Methyl transfer from methylcobalamin to diaquocobinamide, 2698 transfer to specific amino acid acceptors, 1302 Depurination Increase in the.Bnm of yaminobutyric acid-A recognition sites in brain Mutational specificity of depurination, 1494 regions of mice receiving diazepam, 2247 Desensitization 5,6-Dichloro-1-f3-D-ribofuranosylbenzimidazole Phorbol ester induces desensitization of adenylate cyclase and Pausing and premature termination of human RNA polymerase II during phosphorylation of the 8-adrenergic receptor in turkey transcription of adenovirus in vivo and in vitro, 5931 erythrocytes, 4316 cis-Dichlorodianmineplatinum Functional alteration of the ,3-adrenergic receptor during desensitization Association of cytokeratin p39 with DNA in intact Novikoff hepatoma of mammalian adenylate cyclase by P-agonists, 6686 cells, 419 Desmin 3-(3,4-Dichlorophenyl)-1,1-dlhethylurea Intermediate filament cDNAs from BHK-21 cells: Demonstration of Herbicide resistance in Chlamydomonas reinhardtii results from a distinct genes for desmin and vimentin in all vertebrate classes, 5970 mutation in the chloroplast gene for the 32-kilodalton protein of Characterization and regulation in the expression of a gene coding for the photosystem II, 3617 intermediate filament protein desmin, 6909 Dictyostelm Desmosome cAMP pulses coordinate morphogenetic movement during fruiting body Human autoantibodies against desmosomes: Possible causative factors in formation of Dictyostelium minutum, 2122 pemphigus, 2781 Differential cellular distribution of cAMP-dependent protein kinase during Desulfovibrio development of Dictyostelium discoideum, 2127 Desulfovibrio vulgaris hydrogenase: A nonheme iron enzyme lacking Dictyosteliumn transposable element DIRS-1 has 350-base-pair inverted nickel that exhibits anomalous EPR and Mossbauer spectra, 3728 terminal repeats that contain a heat shock promoter, 2660 Detergent 1,2,7,8-Diepoxyoctane Kinetics of thymidine incorporation into detergent-soluble DNA of mouse A selection for myosin heavy chain mutants in the nematode 7056 Caenorhabditis elegans, 4470 lymphocytes, Diet Determination Complex carbohydrate diets are not capable of maintaining normal Homoeosis in Drosophila: The Ultrabithorax larval syndrome, 545 plasma calcium and phosphorus levels in vitamin D-deficient rats, 2352 Homoeosis in Drosophila: The Ultrabithorax larval syndrome Inhibition by restricted-calorie diet of lymphoproliferative disease and (Correction), 2273 renal damage in MRL/lpr mice, 6144 Deuteration Structure of the cholesteryl ester core of human plasma low density Dietary restriction lipoproteins: Selective deuteration and neutron small-angle Influence of early or late dietary restriction on life span and scattering, 4389 immunological parameters in MRL/Mp-lpr/lpr mice, 5831 Development Diethylnitrosamine See also Differentiation and Morphogenesis 0'-Ethyldeoxythymidine, but not 06-ethyldeoxyguanosine, accumulates Labile nature of the visual recovery promoted by reverse occlusion in in hepatocyte DNA of rats exposed continuously to monocularly deprived kittens, 286 diethylnitrosamine, 1692 Homoeosis in Drosophila: The Ultrabithorax larval syndrome, 545 Differentiation A pheromone-induced developmental switch in Caenorhabditis elegans: See also Development and Morphogenesis Temperature-sensitive mutants reveal a wild-type temperature- --Purification of bovine bone morphogenetic protein by hydroxyapatite dependent process, 819 chromatography, 371 Subcortical projections from ectopic neocortical neurons, 964 Long-term cultivation and differentiation of human erythroleukemia cells Developmental regulation of cytokeratins in cells of the rat mammary in a protein-free chemically defined medium, 453 gland studied with monoclonal antibodies, 1203 Variant antigen genes of Trypanosoma brucei: Genomic alteration of a Differential cellular distribution of cAMP-dependent protein kinase during spliced leader orphon and retention of expression-linked copies during development of Dictyostelium discoideum, 2127 differentiation, 684 Homoeosis in Drosophila: The Ultrabithorax larval syndrome Direct observation of 8-crystallin accumulation by laser light-scattering (Correction), 2273 spectroscopy in the chicken embryo lens, 785 Structural relationships among genes that control development: Sequence Divergence in cholesterol biosynthetic rates and 3-hydroxy-3- homology between the Antennapedia, Ultrabithorax, and fushi tarazu methylglutaryl-CoA reductase activity as a consequence of granulocyte loci of Drosophila, 4115 versus monocyte-macrophage differentiation in HL-60 cells, 894 Dexamethasone Characterization of leukemogenic virus produced by a new line of Friend Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor erythroleukemia virus-transformed cells, 1831 2890 Association of phorbol ester-induced hyperphosphorylation and reversible BW755C, regulation of transferrin membrane receptors in HL60 cells, 2016 Diabetes Continuous suppression of globin gene expression and differentiation of Accelerated age-related browning of human collagen in diabetes Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) mellitus, 583 despite the loss of PMA binding sites by down regulation, 2075 Increased rates of polypeptide chain elongation in placental explants from Variations in DNA methylation during mouse cell differentiation in vivo human diabetics, 1366 and in vitro, 2275 Class II HLA-DC ,B-chain DNA restriction fragments differentiate among Disparate differentiation in mouse hemopoietic colonies derived from HLA-DR2 individuals in insulin-dependent diabetes and multiple paired progenitors, 2520 sclerosis, 1774 Molecular cloning of region-specific chorion-encoding RNA Increased free cholesterol in plasma low and very low density sequences, 27% lipoproteins in non-insulin-dependent diabetes mellitus: Its role in the Variant antigen genes of Trypanosoma brucei: Genomic alteration of a inhibition of cholesteryl ester transfer, 2512 spliced leader orphon and retention of expression-linked copies during Autoantibodies to glucosylated proteins in the plasma of patients with differentiation (Correction), 2944 diabetes, 3204 Isolation of flagellated membrane vesicles from Caulobacter crescentus Vasopressin gene is expressed at low levels in the hypothalamus of the cells: Evidence for functional differentiation of polar membrane Brattleboro rat, 5296 domains, 3409 Prevention of some electrophysiologic and biochemical abnormalities with Growth hormone promotes the differentiation of myoblasts and oxygen supplementation in experimental diabetic neuropathy, 6894 preadipocytes generated by azacytidine treatment of 10T½/2 cells, 3429 Diacylglycerol Induction of plasmacytoid differentiation by phorbol ester in B-cell Competitive inhibition by diacylglycerol of specific phorbol ester lymphoma cell lines bearing 8;14 translocations, 3547 binding, 607 Epithelial mouse mammary cell line exhibiting normal morphogenesis in Evidence that the Rous sarcoma virus transforming gene product vivo and functional differentiation in vitro, 3756 phosphorylates phosphatidylinositol and diacylglycerol, 2117 Binding of the differentiation-inducer, granulocyte-colony-stimulating Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 factor, to responsive but not unresponsive leukemic cell lines, 3765 cells: Role of Ca2+-sensitive phospholipid-dependent protein Differentiation of Friend erythroleukemia cells induced by kinase, 5748 benzodiazepines, 3770 Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised Teratogens induce a subset of small heat shock proteins in Drosophila extracellular magnesium induce proliferation of chicken heart primary embryonic cell cultures, 4075 mesenchymal cells, 6418 Expression of specific mRNAs during adipose differentiation: myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in Identification of an mRNA encoding a homologue of myelin P2 saponin-permeabilized human platelets, 7431 protein, 5468 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984) 8065

Differential adhesion of tumor cells to capillary endothelial cells in 7,12-Dimethylbenz[alanthracene vitro, 5739 Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate- Differential expression of mRNAs for a- and P- during effected tumor promotion in mouse skin by nontoxic inhibition of DNA differentiation of the parasitic protozoan Leishmania mexicana, 5782 synthesis, 5858 Electrical polarity in embryos of wild carrot precedes cotyledon Polycyclic aromatic hydrocarbon mutagenesis of human epidermal differentiation, 6064 keratinocytes in culture, 7802 Differentiation of human erythroid cells is associated with increased 0- 3-(2,4-Dinitroanilino)-3'-amino-N-methyldipropylamine glycosylation of the major sialoglycoprotein, glycophorin A, 6752 Visualization of acidic organelles in intact cells by electron Photomorphogenesis in Physarum: Induction of tubulins and sporulation- microscopy, 4838 specific proteins and of their mRNAs, 7117 Dinitrogenase Induction of murine teratocarcinoma cell differentiation by suppression of Structural genes of dinitrogenase and dinitrogenase reductase are poly(ADP-ribose) synthesis, 7132 transcribed from two separate promoters in the broad host range Induction of a Ca ,Mg2+-dependent endonuclease activity during the cowpea Rhizobium strain IRc78, 7358 early stages of murine erythroleukemic cell differentiation, 7461 Dinitrophenol Specific binding of erythropoietin to spleen cells infected with the anemia Visualization of acidic organelles in intact cells by electron strain of Friend virus, 7574 microscopy, 4838 Differentiation antigen Expression of the Thy-1 glycoprotein gene by DNA-mediated gene Dioxin transfer, 5532 Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on Expression of differentiation and murine leukemia virus antigens on cells receptor binding of epidermal growth factor in the hepatic plasma of primary tumors and cell lines derived from chemically induced membrane of rat, guinea pig, mouse, and hamster, 7407 lymphomas of RF/J mice, 7612 Dipeptide Diffusion Two initiation sites detected in the small sl species of reovirus mRNA by Diffusion and binding constants for acetylcholine derived from the falling dipeptide synthesis in vitro, 1084 phase of miniature endplate currents, 1594 Dipeptidyl carboxypeptidase Evidence for rotational contribution to protein-facilitated proton Autoradiographic visualization of angiotensin-converting enzyme in rat transport, 1710 brain with [3H]captopril: Localization to a striatonigral pathway, 1599 Diffusion of a small molecule in the cytoplasm of mammalian cells, 3414 Diphtheria toxin The translational mobility of substances within the cytoplasmic Human dihydrofolate reductase gene is located in chromosome 5 and is matrix, 6747 unlinked to the related pseudogenes, 1484 Cloning, nucleotide sequence, and expression in Escherichia coli of the Diffusion, lateral exotoxin A structural gene of Pseudomonas aeruginosa, 2645 Relationship between lateral diffusion, collision frequency, and electron Cellular ADP-ribosyltransferase with the same mechanism of action as transfer of mitochondrial inner membrane oxidation-reduction diphtheria toxin and Pseudomonas toxin A, 2703 components, 2606 NAD binding site of diphtheria toxin: Identification of a residue within Diffusion, transverse the nicotinamide subsite by photochemical modification with ATP-dependent asymmetric distribution of spin-labeled phospholipids in NAD, 3307 the erythrocyte membrane: Relation to shape changes, 3751 Mechanism of insertion of diphtheria toxin: Peptide entry and pore size Difluoromethylornithine determinations, 3341 Isolation of cloned cDNA encoding mammalian ornithine Autoradiographic assay of mutants resistant to diphtheria toxin in decarboxylase, 3645 mammalian cells in vitro, 6124 Digitonin Dipyridamole Solubilization and characterization of thyrotropin-releasing hormone Dipyridamole inhibits reversion by thymidine of methotrexate effect and receptors from rat brain, 4227 increases drug uptake in Sarcoma 180 cells, 3200 Dihydrofolate reductase Directing element Development of methotrexate resistance in a human squamous cell Distinctive sequence organization and functional programming of an Alu carcinoma of the head and neck in culture, 2873 repeat promoter, 5291 Development of methotrexate resistance in a human squamous cell Disease resistance carcinoma of the head and neck in culture (Correction), 5006 Cloned avirulence gene of Pseudomonas syringae pv. glycinea Dihydrofolate reductase gene determines race-specific incompatibility on Glycine max (L.) Human dihydrofolate reductase gene is located in chromosome 5 and is Merr., 6024 unlinked to the related pseudogenes, 1484 Chromosomal organization of the human dihydrofolate reductase genes: Disequilibrium Dispersion, selective amplification, and a novel form of Maintenance of high disequilibrium in the presence of partial selfing, 4596 polymorphism, 5170 Disulffide bond Dihydropyridine K-chain allotypes and isotypes in the rabbit; cDNA sequences of clones Interactions of maitotoxin with voltage-sensitive calcium channels in encoding b9 suggest an evolutionary pathway and possible role of the cultured neuronal cells, 4582 interdomain disulfide bond in quantitative allotype expression, 1794 Dihydropyridine derivatives prolong the open state of Ca channels in Disulfide bridge cultured cardiac cells, 4824 Role of a disulfide bridge in the immune function of major Calcium channel activation: A different type of drug action, 5580 histocompatibility class I antigen as studied by in vitro (±)-anfi-(7r,8t)-Dihydroxy-(9,1Ot)-epoxy-7,8,9,10-tetrahydrobenzo[alpyrene mutagenesis, 7544 Inhibition of DNA synthesis by an electrophilic metabolite of Diuresis benzo[alpyrene, 5300 Amino acid sequence of homologous rat atrial peptides: Natriuretic (12S)-12,20-Dihydroxyicosatetraenoic acid activity of native and synthetic forms, 2640 12S,20-Dihydroxyicosatetraenoic acid: A new icosanoid synthesized by Specific membrane receptors for atrial natriuretic factor in renal and neutrophils from 12S-hydroxyicosatetraenoic acid produced by vascular tissues, 5946 thrombin- or collagen-stimulated platelets, 903 DNA acid Nuclear matrix DNA from chicken erythrocytes contains 83-globin gene (14R,15S)-14,15-Dihydroxy-5Z,8Z,1OE,12E-icosatetraenoic sequences, 304 Inhibition of human natural killer cell activity by (14R,15S)-14,15- Association of cytokeratin p39 with DNA in intact Novikoff hepatoma dihydroxy-5Z,8Z,1OE,12E-icosatetraenoic acid, 6914 cells, 419 la,25-Dihydroxyvitamin D3 Chloroplast DNA recombination in interspecific hybrids of Activation and fusion induced by la,25-dihydroxyvitamin D3 and their Chlamydomonas: Linkage between a nonmendelian locus for relation in alveolar macrophages, 7112 streptomycin resistance and restriction fragments coding for 16S la,25-Dihydroxyvitamin D3 receptor rRNA, 1164 Interaction of the la,25-dihydroxyvitamin D3 receptor with RNA and Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic polyribonucleotides, 2337 synthetic phage 434 operator, 1307 Subcellular distribution of DNA-binding and non-DNA-binding 1,25- Extensive and widespread homologies between mitochondrial DNA and dihydroxyvitamin D receptors in chicken intestine, 6711 chloroplast DNA in plants, 1946 4,4'-Diisothiocyano-2,2'-stilbenedisulfonate A large interspersed repeat found in mouse DNA contains a long open Dimeric structure of single chloride channels from Torpedo reading frame that evolves as if it encodes a protein, 2308 electroplax, 2772 Homologous recombination between plasmids in mammalian cells can be y-Diketone enhanced by treatment of input DNA, 3153 In vitro evidence that covalent crosslinking of neurofilaments occurs in y- A simple topological method for describing stereoisomers of DNA diketone neuropathy, 4979 catenanes and knots, 3322 2,6-Dimethoxysemiquinone Correlation of lac operator DNA imino proton exchange kinetics with its Interaction of the 2,6-dimethoxysemiquinone and ascorbyl free radicals function, 3665 with Ehrlich ascites cells: A probe of cell-surface charge, 2088 Site-specific carcinogen binding to DNA, 5623 3,4-Dimethyl-2,5-hexanedione Expression of Epstein-Barr virus (EBV) DNA and cloned DNA In vitro evidence that covalent crosslinking of neurofilaments occurs in y- fragments in human lymphocytes following Sendai virus envelope- diketone neuropathy, 4979 mediated gene transfer, 5926 Dimethyl suifoxide Interspecific DNA transformation in Drosophila, 7515 Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts DNA adduct by promoting cortical microtubule assembly, 5449 Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene Induction of a Ca +,Mg2 -dependent endonuclease activity during the sequences of rat liver DNA, 664 early stages of murine erythroleukemic cell differentiation, 7461 DNA alkylation Use of short DNA oligonucleotides for determination of DNA sequence modifications induced by benzo[a]pyrene diol epoxide, 5936 8066 Biological Sciences Subject Index Proc. NatL Acad Sd USA 81 (1984) DNA antibody DNA hybridization A monoclonal anti-DNA antibody also binds to cell-surface Chemically modified nucleic acids as immunodetectable probes in protein(s), 3843 hybridization experiments, 3466 Somatic mutation of the T15 heavy chain gives rise to an antibody with Human genomic library screened with 17-base oligonucleotide probes autoantibody specificity, 5841 yields a novel interferon gene, 6451 DNA assembly DNA, infectious Measurement of the repulsive force between polyelectrolyte molecules in The cloned genome of ground squirrel hepatitis virus is infectious in the ionic solution: Hydration forces between parallel DNA double animal, 5849 helices, 2621 DNA integration DNA binding The retrovirus pol gene encodes a product required for DNA integration: DNA binding activity of polyoma virus large tumor antigen, 1941 Identification of a retrovirus int locus, 7885 DNA-binding protein DNA inversion Major coat protein and single-stranded DNA-binding protein of A genetic switch in vitro: DNA inversion by Gin protein of phage filamentous virus PD, 699 Mu, 2689 Nerve growth factor inhibits the synthesis of a single-stranded DNA DNA library binding protein in pheochromocytoma cells (clone PC12), 2080 Direct isolation of the functional human thymidine kinase gene with a Identification and mapping of polypeptides encoded by the P3HR-1 strain cosmid shuttle vector, 414 of Epstein-Barr virus, 4183 Novel cluster of a-interferon gene sequences in a placental cosmid DNA Subcellular distribution of DNA-binding and non-DNA-binding 1,25- library, 2435 dihydroxyvitamin D receptors in chicken intestine, 6711 DNA, mcronudear Sequence of the bacteriophage SP01 gene coding for transcription factor Elaboration of telomeres in yeast: Recognition and modification of 1, a viral homologue of the bacterial type II DNA-binding termini from Oxytricha macronuclear DNA, 1475 proteins, 7031 DNA-mediated gene transfer DNA-catalyzed solvolysis A pattern of partially homologous recombination in mouse L cells, 206 Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to Expression of the Thy-1 glycoprotein gene by DNA-mediated gene DNA proceed through similar rate-determining steps, 2635 transfer, 5532 DNA circularization Direct transfection of viral and plasmid DNA into the liver or spleen of Directional cloning of DNA fragments at a large distance from an initial mice, 7529 probe: A circularization method, 6812 DNA metabolism DNA cleavage Molecular analysis of the recF gene of Escherichia coli, 4622 Site-specific cleavage of DNA at 8- and 10-base-pair sequences, 983 DNA methylation DNA cloning Preferential binding of estrogen-receptor complex to a region containing In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac the estrogen-dependent hypomethylation site preceding the chicken bacteriophage containing a plasmid replicon, 1480 vitellogenin II gene, 429 Use of adeno-associated virus as a mammalian DNA cloning vector: Insulin-induced reactivation of an inactive herpes simplex thymidine Transduction of neomycin resistance into mammalian tissue culture kinase gene, 838 cells, 6466 Site-specific cleavage of DNA at 8- and 10-base-pair sequences, 983 Directional cloning of DNA fragments at a large distance from an initial Natural fibroin genes purified without using cloning procedures from probe: A circularization method, 6812 fibroin-producing and -nonproducing tissues reveal indistinguishable DNA conformation structure and function, 1644 In Z-DNA the sequence G-C-G-C is neither methylated by Hha I Differential methylation of hypoxanthine phosphoribosyltransferase genes methyltransferase nor cleaved by Hha I restriction endonuclease, 3268 on active and inactive human X chromosomes, 1759 DNA-cytosine methyltransferase Genomic sequencing, 1991 Covalent bond formation between a DNA-cytosine methyltransferase and Variations in DNA methylation during mouse cell differentiation in vivo DNA containing 5-azacytosine, 6993 and in vitro, 2275 DNA damage Methylation of the hypoxanthine phosphoribosyltransferase locus on the Nitroaromatic radiation sensitizers substitute for oxygen in human X chromosome: Implications for X-chromosome neocarzinostatin-induced DNA damage, 3312 inactivation, 2806 Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' to repetitive sequences of rat liver DNA in vivo, 6943 region inactivate the E2a gene of adenovirus type 2, 2950 DNA damage related to increased hydrogen peroxide generation by DNA methylation pattern is determined by the intracellular level of the hypolipidemic drug-induced liver peroxisomes, 7827 methylase, 3278 DNA, detergent-soluble Induction of the metastatic phenotype in a mouse tumor model by Kinetics of thymidine incorporation into detergent-soluble DNA of mouse 5-azacytidine, and characterization of an antigen associated with lymphocytes, 7056 metastatic activity, 3389 The persistence of maternal inheritance in Chlamydomonas despite DNA direct repeat hypomethylation of chloroplast DNA induced by inhibitors, 3438 Specific hepatitis B virus integration in hepatocellular carcinoma DNA Activation of a chicken embryonic globin gene in adult erythroid cells by through a viral 11-base-pair direct repeat, 5350 5-azacytidine and sodium butyrate, 3954 DNA double helix DNA methylation and regulation of the human 13-globin-like genes in Contacts between hormone receptor and DNA double helix within a mouse erythroleukemia cells containing human chromosome glucocorticoid regulatory element of mouse mammary tumor 11, 6618 virus, 3029 DNA, middle-repetitive Contacts between hormone receptor and DNA double helix within a Chromosomal mapping of a middle-repetitive DNA sequence in a cluster glucocorticoid regulatory element of mouse mammary tumor virus of five species of Hawaiian Drosophila, 7146 (Correction), 5892 DNA, mitochondrial DNA, extrachromosomal Expandable varl gene of yeast mitochondrial DNA: In-frame insertions Extrachromosomal copies of transposon Tcl in the nematode can explain the strain-specific protein size polymorphisms, 3148 Caenorhabditis elegans, 4018 Natural interspecies transfer of mitochondrial DNA in amphibians, 5802 Slow virus visna: Reproduction in vitro of virus from extrachromosomal DNA modification DNA, 7212 Modification of DNA by reducing sugars: A possible mechanism for DNA fragment, synthetic nucleic acid aging and age-related dysfunction in gene expression, 105 Specific amino acid substitutions in bacterioopsin: Replacement of a DNA, palindromic restriction fragment in the structural gene by synthetic DNA fragments Structural intermediates of deletion mutagenesis: A role for palindromic containing altered codons, 2285 DNA, 512 DNA fragmentation Demonstration of the production of frameshift and base-substitution Induction of a Ca2 ,Mg2+-dependent endonuclease activity during the mutations by quasipalindromic DNA sequences, 5528 early stages of murine erythroleukemic cell differentiation, 7461 DNA DNA handedness Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in Chiral probes for the handedness of DNA helices: Enantiomers of vitro, 7397 tris(4,7-diphenylphenanthroline)ruthenium(II), 1%1 DNA polymerase Resistance of herpes simplex virus to 9-{[2-hydroxy-1- DNA helical turn (hydroxymethyl)ethoxy]methyl}guanine: Physical mapping of drug An operator at -280 base pairs that is required for repression of araBAD synergism with the viral DNA polymerase locus, 1556 operon promoter: Addition of DNA helical turns between the operator Purification and properties of a pea chloroplast DNA polymerase, 2354 and promoter cyclically hinders repression, 5017 Mammalian DNA polymerase a holoenzymes with possible functions at DNA, hepatitis B virus the leading and lagging strand of the replication fork, 3993 Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone Inhibition of DNA synthesis by an electrophilic metabolite of marrow culture obtained from a patient recently infected with hepatitis benzo[a]pyrene, 5300 B virus, 3526 Characterization and purification of a phage 429-encoded DNA DNA heteroduplex polymerase required for the initiation of replication, 5325 Processing of complex DNA heteroduplexes in Escherichia coli and Cos-1 Replication of bacteriophage 429 DNA replication in vitro: The roles of monkey cells, 5792 terminal protein and DNA polymerase, 5374 Evidence for inclusion of regions of nonhomology in heteroduplex Molecular mechanisms of manganese mutagenesis, 7378 products of bacteriophage X recombination, 7180 A separate editing for DNA replication: The e subunit of DNA homology Escherichia coli DNA polymerase III holoenzyme, 7747 Extensive homology exists between Marek disease herpesvirus and its Identification of a higher molecular weight DNA polymerase a catalytic vaccine virus, herpesvirus of turkeys, 3365 polypeptide in monkey cells by monoclonal antibody, 7777 The absence of RNase H allows replication of pBR322 in Escherichia coli mutants lacking DNA polymerase I, 7845 Biological Sciences Subject Index Proc. Natl. Acadc Sci USA 81 (1984) 8067

DNA polymorphism DNA repliation DNA polymorphic loci mapped by human chromosomes 3, 5, 9, 11, 17, See also DNA synthesis 18, and 22, 2447 Template requirements for initiation of phage 4)29 DNA replication in Strategies for multilocus linkage analysis in humans, 3443 vitro, 80 Linkage disequilibrium and evolutionary relationships of DNA variants Template requirements for the initiation of adenovirus DNA (restriction enzyme fragment length polymorphisms) at the serum replication, 100 albumin locus, 3486 Protein HU in the enzymatic replication of the chromosomal origin of Chromosomal organization of the human dihydrofolate reductase genes: Escherichia coli, 424 Dispersion, selective amplification, and a novel form of RNase H confers specificity in the dnaA-dependent initiation of polymorphism, 5170 replication at the unique origin of the Escherichia coli chromosome in Ribosomal DNA spacer-length polymorphisms in barley: Mendelian vivo and in vitro, 1040 inheritance, chromosomal location, and population dynamics, 8014 Purification and properties of a pea chloroplast DNA polymerase, 2354 DNA pressure DNA topoisomerase II mutant of Saccharomyces cerevisiae: Measurement of the repulsive force between polyelectrolyte molecules in Topoisomerase II is required for segregation of daughter molecules at ionic solution: Hydration forces between parallel DNA double the termination of DNA replication, 2616 helices, 2621 DNA sequences required for the in vitro replication of adenovirus DNA primase DNA, 3069 Mouse primase initiation sites in the origin region of simian virus 40, 2342 A cis-acting element from the Epstein-Barr viral genome that permits DNA-protein interaction stable replication of recombinant plasmids in latently infected Essential sites at TnlO 3452 cells, 3806 transposon termini, Isolation of human DNA sequences that bind to nuclear factor I, a host Molecular basis of DNA sequence recognition by the catabolite gene protein involved in adenovirus DNA replication, 4013 activator protein: Detailed inferences from three mutations that alter cis-acting mutations that affect rop protein control of plasmid copy DNA sequence specificity, 7274 number, 4465 DNA rearrangement Induction of replicative DNA synthesis in quiescent human fibroblasts by Genes required for initiation and resolution steps of mating-type switching DNA damaging agents, 4828 in fission yeast, 3481 Replication of bacteriophage 429 DNA replication in vitro: The roles of Different joining region J elements of the murine K immunoglobulin light terminal protein and DNA polymerase, 5374 chain locus are used at markedly different frequencies, 4756 Simian virus 40 DNA replication in vitro, 6973 Specific DNA rearrangements in synchronously developing nuclei of Kinetics of thymidine incorporation into detergent-soluble DNA of mouse Tetrahymena, 7383 lymphocytes, 7056 DNA repair Multiple initiation sites of DNA replication flanking the origin region of Ionizing radiation and tritium transmutation both cause formation of 5- Xdv genome, 7402 hydroxymethyl-2'-deoxyuridine in cellular DNA, 318 Involvement of the activated form of RecA protein in SOS mutagenesis Correction of complex heteroduplexes made of mouse H-2 gene and stable DNA replication in Escherichia coli, 7539 sequences in Escherichia coli K-12, 503 Coordinate replication of members of the multigene family of core and H1 Altered temporal expression of DNA repair in hypermutable Bloom's human histone genes, 7723 syndrome cells, 757 A separate editing exonuclease for DNA replication: The E subunit of Exposure of nondividing populations of primary human fibroblasts to UV Escherichia coli DNA polymerase III holoenzyme, 7747 (254 nm) radiation induces a transient enhancement in capacity to The absence of RNase H allows replication of pBR322 in Escherichia coli repair potentially lethal cellular damage, 781 mutants lacking DNA polymerase I, 7845 Adaptive response in mammalian cells: Crossreactivity of different DNA replication, sequential pretreatments of cytotoxicity as contrasted to mutagenicity, 1062 Invariant temporal order of replication of the four actin gene loci during 04-Ethyldeoxythymidine, but not 06-ethyldeoxyguanosine, accumulates the naturally synchronous mitotic cycles of Physarum in hepatocyte DNA of rats exposed continuously to polycephalum, 6393 diethylnitrosamine, 1692 DNA, ribosomal Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2- Glucocorticoid inhibition of initiation of transcription of the DNA acetylaminofluorene, 2831 encoding rRNA (rDNA) in lymphosarcoma P1798 cells, 718 Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from DNA, satellite Escherichia coli DNA requires the uvrA, uvrB, and urvC gene Different central nervous system cell types display distinct and products, 3821 nonrandom arrangements of satellite DNA sequences, 3123 Hydroxymethyluracil DNA glycosylase in mammalian cells, 4003 DNA secondary structure Induction of specific Escherichia coli genes by sublethal treatments with Structural intermediates of deletion mutagenesis: A role for palindromic alkylating agents, 4110 DNA,9512 Spontaneous and mutagen-induced deletions: Mechanistic studies in Mechanism of the concerted action of recA protein and helix-destabilizing Salmonella tester strain TA102, 4457 proteins in homologous recombination, 2757 Induction of replicative DNA synthesis in quiescent human fibroblasts by DNA sequence DNA damaging agents, 4828 Strategy for the mass spectrometric verification and correction of the Inhibition of DNA synthesis by an electrophilic metabolite of primary structures of proteins deduced from their DNA benzo[a]pyrene, 5300 sequences, 1956 Thymine glycol and thymidine glycol in human and rat urine: A possible DNA sequence recognition assay for oxidative DNA damage, 5633 Molecular basis of DNA sequence recognition by the catabolite gene Transient complementation of xeroderma pigmentosum cells by activator protein: Detailed inferences from three mutations that alter microinjection of poly(A)+ RNA, 5676 DNA sequence specificity, 7274 Accumulation of DNA strand breaks and methotrexate cytotoxicity, 5694 DNA, single-stranded Processing of complex DNA heteroduplexes in Escherichia coli and Cos-1 Major coat protein and single-stranded DNA-binding protein of monkey cells, 5792 filamentous virus Pf3, 699 mu-2: Mutator gene in Drosophila that potentiates the induction of Nerve growth factor inhibits the synthesis of a single-stranded DNA terminal deficiencies, 6090 binding protein in pheochromocytoma cells (clone PC12), 2080 Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in Cleavage of single-stranded DNA by the 4X174 A* protein: The A*- vitro, 7397 single-stranded DNA covalent linkage, 4285 DNA repeat Ul RNA-protein complex preferentially binds to both 5' and 3' splice Internal duplication in human a, and p1 interferons, 7171 junction sequences in RNA or single-stranded DNA, 6281 DNA, repetitive Isolation and visualization of active presynaptic filaments of recA protein Molecular hybridization under conditions of high stringency permits and single-stranded DNA, 7026 cloned DNA segments containing reiterated DNA sequences to be DNA spacer assigned to specific chromosomal locations, 520 Are DNA spacers relics of gene amplification events?, 1768 Rearranged sequences of a human Kpn I element, 1012 DNA strand break tau, a repeated DNA sequence in yeast, 2965 Accumulation of DNA strand breaks and methotrexate cytotoxicity, 5694 Minichromosomal repetitive DNA in Trypanosoma cruzi: Its use in a DNA structure high-sensitivity parasite detection assay, 3356 Two-dimensional 'H NMR study of the X operator site OL): A sequential Extrachromosomal copies of transposon Tcl in the nematode assignment strategy and its application, 130 Caenorhabditis elegans, 4018 Model of specific complex between catabolite gene activator protein and Repetitive structure in the long-terminal-repeat element of a type II B-DNA suggested by electrostatic complementarity, 3973 human T-cell leukemia virus, 4617 Evidence for the existence of stable curvature of DNA in solution, 4632 Characterization of a cloned DNA sequence that is present at Statistical mechanics of the B -* Z transition of DNA: Contribution of centromeres of all human autosomes and the X chromosome and shows diffuse ionic interactions, 5116 polymorphic variation, 4884 Demonstration of the production of frameshift and base-substitution Different evolutionary behavior of structurally related, repetitive mutations by quasipalindromic DNA sequences, 5528 sequences occurring in the same Balbiani ring gene in Chironomus Salt-induced Z-A-Z transition sequence in the mixed ribo-deoxyribo tentans, 5165 copolymer poly(rG-dC)poly(rG-dC), 7284 Genomic structure and possible retroviral origin of the chicken CRI DNA, supercolied repetitive DNA sequence family, 6667 Restriction endonucleases can be used to study B-Z junctions in Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene 5714 to repetitive sequences of rat liver DNA in vivo, 6943 supercoiled DNA, Identification of a retrovirus-like element in human 7510 DNA supercoiling repetitive DNA, The free energy of DNA supercoiling is enthalpy-determined, 1312 Regulation of bacterial DNA supercoiling: Plasmid linking numbers vary with growth temperature, 4046 8068 Biological Sciences Subject Index Proc. NatL. Acad. Sci USA 81 (1984)

DNA synthesis Structural relationships among genes that control development: Sequence See also DNA replication homology between the Antennapedia, Ultrabithorax, and fushi tarazu Microinjected pBR322 stimulates cellular DNA synthesis in Swiss 3T3 loci of Drosophila, 4115 cells, 400 Genetic basis of male sterility in hybrids between two closely related Increased intracellular concentration of an initiator protein markedly species of Drosophila, 4444 reduces the minimal sequence required for initiation of DNA Long terminal repeat nucleotide sequence and specific insertion of the synthesis, 1336 gypsy transposon, 4462 Biologically active synthetic fragments of epidermal growth factor: Inducible transcription and puffing in Drosophila melanogaster Localization of a major receptor-binding region, 1351 transformed with hsp7O-phage X hybrid heat shock genes, 5509 Inhibition of DNA synthesis by an electrophilic metabolite of Evidence for the presence of makisterone A in Drosophila larvae and the benzo[a]pyrene, 5300 secretion of 20-deoxymakisterone A by the ring gland, 5643 Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 mu-2: Mutator gene in Drosophila that potentiates the induction of cells: Role of Ca2+-sensitive phospholipid-dependent protein terminal deficiencies, 6090 kinase, 5748 Selective destruction of a host blood cell type by a parasitoid wasp, 6154 Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate- Specific protein modifications are altered in a temperature-sensitive effected tumor promotion in mouse skin by nontoxic inhibition of DNA Drosophila developmental mutant, 6422 synthesis, 5858 Sequences homologous to P elements occur in Drosophila DNA topoisomerase paulistorum, 6794 Mechanism of antitumor drug action: Poisoning of mammalian DNA Inheritance of a secondary sexual character in Drosophila silvestris, 6904 topoisomerase II on DNA by 4'-(9-acridinylamino)methanesulfon-m- A protein kinase activity tightly associated with Drosophila type II DNA anisidide, 1361 topoisomerase, 6938 DNA topoisomerase II mutant of Saccharomyces cerevisiae: Drosophila DNA topoisomerase I is associated with transcriptionally Topoisomerase II is required for segregation of daughter molecules at active regions of the genome, 6958 the termination of DNA replication, 2616 Chromosomal mapping of a middle-repetitive DNA sequence in a cluster Mammalian DNA polymerase a holoenzymes with possible functions at of five species of Hawaiian Drosophila, 7146 the leading and lagging strand of the replication fork, 3993 Related cell-surface antigens expressed with positional specificity in A protein kinase activity tightly associated with Drosophila type II DNA Drosophila imaginal discs, 7485 topoisomerase, 6938 Interspecific DNA transformation in Drosophila, 7515 Drosophila DNA topoisomerase I is associated with transcriptionally Drug action active regions of the genome, 6958 Calcium channel activation: A different type of drug action, 5580 DNA topology Drug oxidation Regulation of bacterial DNA supercoiling: Plasmid linking numbers vary Characterization of a human liver cytochrome P-450 involved in the with growth temperature, 4046 oxidation of debrisoquine and other drugs by using antibodies raised to DNA transfection the analogous rat enzyme, 7348 Molecular cloning of the mouse ouabain-resistance gene, 1489 Drug synergism Recombination of transfected in vertebrate cells in culture, 3476 Resistance of herpes simplex virus to 9-{[2-hydroxy-1- DNA transfer (hydroxymethyl)ethoxy]methyl}guanine: Physical mapping of drug Natural interspecies transfer of mitochondrial DNA in amphibians, 5802 synergism with the viral DNA polymerase locus, 1556 DNA, transforming Drug targeting Small fragments of herpesvirus DNA with transforming activity contain Selective killing of Fc-receptor-bearing tumor cells through endocytosis insertion sequence-like structures, 4736 of a drug-carrying immune complex, 1445 DNA transposition DT-diaphorase Extensive and widespread homologies between mitochondrial DNA and Regulation of glutathione transferase and DT-diaphorase mRNAs in chloroplast DNA in plants, 1946 persistent hepatocyte nodules during chemical DNA virus hepatocarcinogenesis, 5091 DNA and RNA virus species are inhibited by xanthates, a class of DU-PAN-2 antigen antiviral compounds with unique properties, 3263 Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) DNase in serum and ascites of patients with adenocarcinoma, 5242 See Deoxyribonuclease Duchenne muscular dystrophy. Dopa decarboxylase Monensin-induced inhibition of cell spreading in normal and dystrophic Mutations in the dopa decarboxylase gene affect learning in human fibroblasts, 4960 Drosophila, 3577 Abnormal collagen metabolism in cultured skin fibroblasts from patients Dopamine with Duchenne muscular dystrophy, 5130 Mutations in the dopa decarboxylase gene affect learning in Defective Ca2' metabolism in Duchenne muscular dystrophy: Effects on Drosophila, 3577 cellular and viral growth, 7617 Dopamine neurodynamics Duck Chaotic behavior in dopamine neurodynamics, 1244 Liver disease associated with duck hepatitis B virus infection of domestic Dopamine receptor ducks, 898 Spiperone: Evidence for uptake into secretory granules, 1867 Ductal development Dopamine receptor turnover rates in rat striatum are age-dependent, 3910 In vivo, cAMP stimulates growth and morphogenesis of mouse mammary Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3- ducts, 4950 (3-hydroxyphenyl)-N-(1-propyl)piperidine, 4983 Dynamic filtering NMR with to a opiates and qertain antipsychotic drugs mutually inhibit (+)-[3H]SKF Dynamic filtering by two-dimensional 1H application phage 10,047 and [ H]haloperidol binding in guinea pig brain membranes, 5618 X repressor, 6019 Dot-immunobinding assay ATPase A quantitative dot-immunobinding assay for proteins using nitrocellulose erythro-9-[3-(2-Hydroxynonyl)]adenine is an effective inhibitor of cell membrane filters, 1684 motility and actin assembly, 6044 Down syndrome Dynorphin Increased adhesiveness of Down syndrome fetal fibroblasts in vitro, 2426 Differential processing of prodynorphin and proenkephalin in specific Drift regions of the rat brain, 6886 Drift and mutation with a finite number of allelic states, 530 Dynorphin-converting enzyme DrosophUa Dynorphin converting enzyme with unusual specificity from rat Monoclonal antibodies detect the conservation of muscarinic cholinergic brain, 1892 receptor structure from Drosophila to human brain and detect possible Dysautonomia structural homology with a,-adrenergic receptors, 272 Biochemical and anatomical effects of antibodies against nerve growth Streptococcal L-forms isolated from Drosophila paulistorum semispecies factor on developing rat sensory ganglia, 1580 cause sterility in male progeny, 282 Homoeosis in Drosophila: The Ultrabithorax larval syndrome, 545 E26 virus Major heat shock gene of Drosophila and the Escherichia coli heat- Avian myeloblastosis virus and E26 virus oncogene products are nuclear inducible dnaK gene are homologous, 848 proteins, 4265 Cloned Drosophila alcohol dehydrogenase genes are correctly expressed (E)-5-(2-Bromovinyl)-2'-deoxyuridine after transfection into Drosophila cells in culture, 1701 Herpes simplex virus latency in isolated human neurons, 6217 Molecular genetics of a biological clock in Drosophila, 2142 Identification, molecular cloning, and mutagenesis of Saccharomyces Ecdysone cerevisiae RNA polymerase genes, 2157 Evidence for the presence of makisterone A in Drosophila larvae and the Homoeosis in Drosophila: The Ultrabithorax larval syndrome secretion of 20-deoxymakisterone A by the ring gland, 5643 (Correction), 2273 13-Ecdysterone Lampbrush loop-specific protein of Drosophila hydei, 3404 Teratogens induce a subset of small heat shock proteins in Drosophila Mutations in the dopa decarboxylase gene affect learning in primary embryonic cell cultures, 4075 Drosophila, 3577 Eclosion Mutants suppressing in trans chorion gene amplification in Hormonal control of eclosion of flies from the puparium, 1457 Drosophila, 3773 Eclosion hormone Artificial selection for a secondary sexual character in males of Cyclic GMP may serve as a second messenger in peptide-induced muscle Drosophila silvestris from Hawaii, 3915 degeneration in an insect, 6718 Teratogens induce a subset of small heat shock proteins in Drosophila Ectopia primary embryonic cell cultures, 4075 Subcortical projections from ectopic neocortical neurons, 964 Biological Sciences Subject Index Proc. NatL. Acad. Scd USA 81 (1984) 8069

Eggshell Electroporation Mutants suppressing in trans chorion gene amplification in Enhancer-dependent expression of human K immunoglobulin genes Drosophila, 3773 introduced into mouse pre-B lymphocytes by electroporation, 7161 Eigen hypercycle Electrostatic complementarity A model for the origin of biological catalysis, 1751 Model of specific complex between catabolite gene activator protein and A model for the origin of biological catalysis (Correction), 4599 B-DNA suggested by electrostatic complementarity, 3973 Electric field Electrostatic fluctuation Monitoring fibroblast behavior in tissue culture with an applied electric Dynamics of enzymatic reactions, 444 field, 3761 Electrostatic interaction Electric organ Structure of deoxyhemoglobin Cowtown [His HC3(146)0-*Leu]: Origin of Creatine kinase protein sequence encoded by a cDNA made from the alkaline Bohr effect and electrostatic interactions in Torpedo californica electric organ mRNA, 7007 hemoglobin, 4781 Electrical activity Macroscopic models for studies of electrostatic interactions in proteins: Electrical activity and cytosolic calcium regulate levels of tetrodotoxin- Limitations and applicability, 4785 sensitive sodium channels in cultured rat muscle cells, 262 Electrotonic coupling Electrical block Determination of synaptic phenotype: Insulin and cAMP independently Time and voltage windows for reversing the electrical block to initiate development of electrotonic coupling between cultured fertilization, 1436 sympathetic neurons, 6235 Electrical field Elicitor Perpendicular orientation and directional migration of amphibian neural Elicitor rapidly induces chalcone synthase mRNA in Phaseolus vulgaris crest cells in dc electrical fields, 160 cells at the onset of the phytoalexin defense response, 5724 Electrical polarity Ellipticine Electrical polarity in embryos of wild carrot precedes cotyledon Regioselective arylation of ribose in adenosine and guanosine with the differentiation, 6064 antitumor drug N2-methyl-9-hydroxyellipticinium acetate, 1297 Electrical stimulation Elongation Electrical stimulation increases phosphorylation of tyrosine hydroxylase Isolation of an active transcription initiation complex from HeLa cell-free in superior cervical ganglion of rat, 7243 extract, 5916 Electron donor P+. Elongation factor Structural studes of the primary donor cation radical P` in reaction Sequence of the initiation factor IF2 gene: Unusual protein features and centers of Rhodospirillum rubrum by electron-nuclear double homologies with elongation factors, 7787 resonance in solution, 1401 Elongation factor 2 Electron microscopy Cellular ADP-ribosyltransferase with the same mechanism of action as Visualization of acidic organelles in intact cells by electron diphtheria toxin and Pseudomonas toxin A, 2703 microscopy, 4838 Chromosomal assignment of the gene for human elongation factor 2, 3158 Radial distributions of density within macromolecular complexes Elongation factor Tu determined from dark-field electron micrographs, 6363 Cross-linking of tRNA at two different sites of the elongation factor Electron nuclear double resonance Tu, 3969 Electron nuclear double resonance evidence supporting a monomeric Embryo transfer nature for P700' in spinach chloroplasts, 1098 Birth of rhesus monkey infant after in vitro fertilization and nonsurgical "N electron nuclear double resonance of the primary donor cation radical embryo transfer, 2218 P.. in reaction centers of Rhodopseudomonas sphaeroides: Additional Embryogenesis evidence for the dimer model, 7792 Expression of cellular oncogenes during embryonic and fetal development Electron paramagnetic resonance of the mouse, 7141 Some plant leaves have orientation-dependent EPR and NMR Embryonal carcinoma cell spectra, 748 Integration-specific retrovirus expression in embryonal carcinoma Electron transfer cells, 6627 Tunneling in Chromatium chromatophores: Detection of a Hopfield Construction of a retrovirus capable of transducing and expressing genes charge-transfer band, 135 in multipotential embryonic cells, 7137 Kinetics of electron transfer between cardiac cytochromes cl and c, 2026 Embryonic globin Relationship between lateral diffusion, collision frequency, and electron Activation of a chicken embryonic globin gene in adult erythroid cells by transfer of mitochondrial inner membrane oxidation-reduction 5-azacytidine and sodium butyrate, 3954 components, 2606 Embryonicinduction Electron transport Cell adhesion and morphogenesis: The regulator hypothesis, 1460 Single catalytic site model for the oxidation of ferrocytochrome c by Emphysema mitochondrial cytochrome c oxidase, 347 Expression of a human ai-antitrypsin cDNA in the yeast Saccharomyces Regulation of protein metabolism: Coupling of photosynthetic electron 6594 transport to in vivo degradation of the rapidly metabolized 32-kilodalton cerevisiae, protein of the chloroplast membranes, 1380 Encapsidation Photoreduction of ferredoxin with various electron donors: Support for Chloroplast DNA transcripts are encapsidated by tobacco mosaic virus the Z scheme of photosynthetic electron transport, 2070 coat protein, 1719 Effects of Cu deficiency on photosynthetic electron transport, 2369 Encephalitis virus 31P NMR study of improvement in oxidative phosphorylation by vitamins An evolutionary tree relating eight alphaviruses, based on amino-terminal K3 and C in a patient with a defect in electron transport at complex III sequences of their glycoproteins, 4702 in skeletal muscle, 3529 Encephalomyocarditis virus Electrophoresis Injection of mice with antibody to interferon renders peritoneal Detection of erythrocyte membrane proteins, sialoglycoproteins, and macrophages permissive for vesicular stomatitis virus and lipids in the same polyacrylamide gel using a double-staining encephalomyocarditis virus, 602 technique, 1733 Encephalopathy Mice homozygous for chromosomal deletions in the albino locus region Development of encephalopathic features similar to Reye syndrome in lack specific polypeptides in two-dimensional gels, 2132 rabbits, 6169 Electrophoretic type Encounter rate Evidence for clinal population structure in Escherichia coli, 198 Search, encounter rates, and the evolution of anisogamy, 6078 Distribution of DNA insertion element IS5 in natural isolates of End-labeling Escherichia coli, 4500 Heat-labile alkaline phosphatase from Antarctic bacteria: Rapid 5' end- Electrophoretic variant labeling of nucleic acids, 6691 Failure to demonstrate mutations affecting protein structure or function in Endocrine organ children with congenital defects or born prematurely, 5499 The mononuclear phagocyte system of the mouse defined by Ekctrophorus immunohistochemical localization of antigen F4/80: Macrophages of Reconstitution of neurotoxin-modulated ion transport by the voltage- endocrine organs, 4174 regulated sodium channel isolated from the electroplax of Endocytosis Electrophorus electricus, 1239 Morphologic characterization of the pathway of transferrin endocytosis Shared antigenic determinant between the Electrophorus acetylcholine and recycling in human KB cells, 175 receptor and a synaptic component on chicken ciliary ganglion Cytosolic calcium regulates epidermal growth factor endocytosis in rat neurons, 3223 pancreas and cultured fibroblasts, 461 Acetylcholine receptor (from Electrophorus electricus): A comparison of Rapid release of galactose-terminated ligands after endocytosis by hepatic single-channel current recordings and chemical kinetic parenchymal cells: Evidence for a role of carbohydrate structure in the measurements, 5281 release of internalized ligand from receptor, 466 Single-channel properties of the reconstituted voltage-regulated Na Selective killing of Fc-receptor-bearing tumor cells through endocytosis channel isolated from the electroplax of Electrophorus electricus, 5594 of a drug-carrying immune complex, 1445 Electroplax Two populations of prelysosomal structures transporting Reconstitution of neurotoxin-modulated ion transport by the voltage- asialoglycoproteins in rat liver, 2995 regulated sodium channel isolated from the electroplax of Rapid internalization of the transferrin receptor in K562 cells is triggered Electrophorus electricus, 1239 by ligand binding or treatment with a phorbol ester, 3005 Dimeric structure of single chloride channels from Torpedo Clathrin-coated vesicles from rat liver: Enzymatic profile and electroplax, 2772 characterization of ATP-dependent proton transport, 3108 Single-channel properties of the reconstituted voltage-regulated Na Visualization of acidic organelles in intact cells by electron channel isolated from the electroplax of Electrophorus electricus, 5594 microscopy, 4838 8070 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984)

Infection of B lymphocytes by a human herpesvirus, Epstein-Barr virus, Expression of immunoglobulin heavy chain at a high level in the absence is blocked by calmodulin antagonists, 4955 of a proposed immunoglobulin enhancer element in cis, 2452 Receptor-mediated endocytosis of low density lipoprotein: Somatic cell Mapping of DNase I-hypersensitive sites in the upstream DNA of human mutants define multiple genes required for expression of surface- embryonic E-globin gene in K562 leukemia cells, 2718 receptor activity, 5454 Translocated c-myc oncogene of Burkitt lymphoma is transcribed in Endocytosis in alveolar type II cells: Effect of charge and size of plasma cells and repressed in lymphoblastoid cells, 3170 tracers, 6054 Repetitive structure in the long-terminal-repeat element of a type II Uptake of lectins by pulmonary alveolar type II cells: Subsequent human T-cell leukemia virus, 4617 deposition into lamellar bodies, 6383 Distinctive sequence organization and functional programming of an Alu Partial primary structure of human pregnancy zone protein: Extensive repeat promoter, 5291 sequence homology with human a2-macroglobulin, 7353 A viable simian virus 40 variant that carries a newly generated sequence Endogenous ligand reiteration in place of the normal duplicated enhancer element, 6652 The presence of pig brain of an endogenous equivalent of apamin, the bee Two regulatory elements for immunoglobulin K light chain gene venom peptide that specifically blocks Ca2+-dependent K+ expression, 7041 channels, 7228 Enhancer-dependent expression of human K immunoglobulin genes Endometrigl carcinoma introduced into mouse pre-B lymphocytes by electroporation, 7161 Cell surface antigens of human ovarian and endometrial carcinoma Genetic properties and chromatin structure of the yeast gal regulatory defined by mouse monoclonal antibodies, 568 element: An enhancer-like sequence, 7865 Endonuclease Enkephalin Induction of a Ca2 ,Mg2 -dependent endonuclease activity during the Role of membrane lipids in peptide hormone function: Binding of early stages of murine erythroleukemic cell differentiation, 7461 enkephalins to micelles, 61 Isolation and identification of enkephalins in pedal ganglia of Mytilus Endonuclease S1 edulis (Mollusca), 955 Endonuclease S1-sensitive site in chicken pro-a2(I) collagen 5' flanking Changes in rat adrenal catecholamines and proenkephalin metabolism gene region, 1659 after denervation, 3587 Endopeptidase Visualization of opiate receptor upregulation by light microscopy Enzymes processing somatostatin precursors: An Arg-Lys autoradiography, 3893 esteropeptidase from the rat brain cortex converting somatostatin-28 Differential processing of prodynorphin and proenkephalin in specific into somatostatin-14, 6662 regions of the rat brain, 6886 Endoplasmic reticulum Denervation of rat adrenal glands markedly increases preproenkephalin Assembly in vitro of a spanning membrane protein of the endoplasmic mRNA, 7221 reticulum: The El glycoprotein of coronavirus mouse hepatitis virus Molecular cloning and sequence determination of rat preproenkephalin A59, 1421 cDNA: Sensitive probe for studying transcriptional changes in rat Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an tissues, 7651 integral glycoprotein of the endoplasmic reticulum, 1674 Compartmental distribution of striatal cell bodies expressing Endoproteinase Lys-C [Metlenkephalin-like immunoreactivity, 7980 Intact proenkephalin is the major enkephalin-containing peptide produced Intact proenkephalin is the major enkephalin-containing peptide produced in rat adrenal glands after denervation, 7985 in rat adrenal glands after denervation, 7985 Endorhamnosidase Enkephalin biosynthesis Single amino acid substitutions influencing the folding pathway of the Alternative modes of enkephalin biosynthesis regulation by reserpine and phage P22 tail spike endorhamnosidase, 6584 cyclic AMP in cultured chromaffin cells, 3949 Endorphin Enkephalin convertase Differential processing of prodynorphin and proenkephalin in specific Enkephalin convertase localization by regions of the rat brain, 6886 [3Hlguanidinoethylmercaptosuccinic acid autoradiography: Selective 18-Endorphin association with enkephalin-containing neurons, 6543 f-Endorphin-(1-27) is an antagonist of P-endorphin analgesia, 1389 Enterotoxin f-Endorphin: Characterization of binding sites specific for the human Staphylococcal enterotoxin A gene is associated with a variable genetic hormone in human glioblastoma SF126 cells, 2921 element, 5179 ,B-Endorphin-induced analgesia is inhibited by synthetic analogs of /3- Mechanism of toxin secretion by Vibrio cholerae investigated in strains endorphin, 3074 harboring plasmids that encode heat-labile enterotoxins of Escherichia Secretion of foreign proteins from Saccharomyces cerevisiae directed by coli, 7752 a-factor gene fusions, 5330 Enthalpy Endosymbiont The free energy of DNA supercoiling is enthalpy-determined, 1312 Pronounced structural similarities between the small subunit ribosomal Entrainment RNA genes of wheat mitochondria and Escherichia coli, 493 Transitions between oscillatory modes in a glycolytic model system, 4394 Endothelial cell Envelope gene product Human endothelial cells in culture produce platelet-activating factor Serological cross-reactivity between envelope gene products of type I and (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with type II human T-cell leukemia virus, 7579 thrombin, 3534 Envelope protein Modification of low density lipoprotein by endothelial cells involves lipid Envelope proteins of human T-cell leukemia virus: Expression in peroxidation and degradation of low density lipoprotein Escherichia coli and its application to studies of env gene phospholipids, 3883 functions, 6202 Differential adhesion of tumor cells to capillary endothelial cells in Environment vitro, 5739 4105 Brain- and liver cell-derived factors are required for growth of human Trophic links of community food webs, endothelial cells in serum-free culture, 6413 Enzyme Expression of the sis gene by endothelial cells in culture and in vivo, 6772 Soliton-assisted unidirectional circulation in a biochemical cycle, 4386 Detection of superoxide generated by endothelial cells, 7269 Enzyme activation Infection of human endothelial cells by human T-lymphotropic virus type Cytosolic Ca '-dependent neutral proteinases from rabbit liver: I, 7588 Activation of the proenzymes by Ca2+ and substrate, 53 Infection of human endothelial cells by human T-cell leukemia virus type Enzyme active center I, 7591 Bis[cyclo(histidylhistidine)]copper(II) complex that mimicks the active Endothelium center of superoxide dismutase has its catalytic activity, 3283 Leukotriene B4 action on endothelium mediates augmented neutrophil/ Charge state of His-57-Asp-102 couple in a transition state analogue- endothelial adhesion, 2191 trypsin complex: A molecular orbital study, 6266 Atrial natriuretic factor elicits an endothelium-independent relaxation and Enzyme activity activates particulate guanylate cyclase in vascular smooth muscle, 7661 Effects of pH on the structure and function of carboxypeptidase A: Endotoxic shock Crystallographic studies, 7767 Multiple opioid receptors in endotoxic shock: Evidence for 8 involvement Enzyme, allosteric and tL-8 interactions in vivo, 2898 Structure of unligated aspartate carbamoyltransferase of Escherichia coli Endotoxin at 2.6-A resolution, 4037 Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones, 1053 Dynamics of enzymatic reactions, 444 Interaction between endotoxin and human monocytes: Characteristics of Enzyme dynamics the binding of 3H-labeled lipopolysaccharide and 5tCr-labeled lipid A Dynamics of enzymatic reactions, 444 before and after the induction of endotoxin tolerance, 3491 Enzyme evolution Energy coupling Birth of a unique enzyme from an alternative reading frame of the ATP-binding sites in the membrane components of the histidine preexisted, internally repetitious coding sequence, 2421 permease, a periplasmic transport system, 7333 Human alcohol dehydrogenase: Structural differences between the p and Energy transduction y subunits suggest parallel duplications in isoenzyme evolution and On the mechanism of energy transduction in myosin subfragment 1, 2060 predominant expression of separate gene descendants in livers of Energy transfer different mammals, 6320 Application of the Dale-Eisinger analysis to proximity mapping in the Enzyme inactivation contractile system, 3723 Radiation inactivation of oligomeric enzyme systems: Theoretical Picosecond fluorescence decay of tryptophans in myoglobin, 4399 considerations, 150 Enhancer Enzyme-linked immunosorption assay Stimulation of in vitro transcription from heterologous promoters by the Monoclonal antibody specific for the mutant PiZ a1-antitrypsin and its simian virus 40 enhancer, 308 application in an ELISA procedure for identification of PiZ gene carriers, 5690 Biological Sciences Subject Index Proc. Nati. Acad. Sci USA 81 (1984) 8071

Enzyme mechanism Epstein-Barr nuclear antigen Cryospectrokinetic characterization of intermediates in biochemical Identification of Epstein-Barr nuclear antigen polypeptide in mouse and reactions: Carboxypeptidase A, 5041 monkey cells after gene transfer with a cloned 2.9-kilobase-pair Enzyme structure subfragment of the genome, 43 Radiation inactivation of oligomeric enzyme systems: Theoretical Antibodies against a synthetic peptide identify the Epstein-Barr virus- considerations, 150 determined nuclear antigen, 4652 Eocyte U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear Eocytes: A new ribosome structure indicates a kingdom with a close antigen 2, 7632 relationship to eukaryotes, 3786 Epstein-Barr virus Eosinophil Possible DNA-RNA tumor virus interaction in human lymphomas: Stimulation of human granulocyte function by monoclonal antibody Expression of retroviral proteins in Ramos lymphoma lines is enhanced -WEM-G1, 1818 after conversion with Epstein-Barr virus, 33 A cis-acting element from the Epstein-Barr viral genome that permits Epidermal cell thymocyte-activing factor stable replication of recombinant plasmids in latently infected Effect of ultraviolet radiation on production of epidermal cell thymocyte- cells, 3806 activating factor/interleukin 1 in vivo and in vitro, 1198 Possible DNA-RNA tumor virus interaction in human lymphomas: Epidermal growth factor Expression of retroviral proteins in Ramos lymphoma lines is enhanced Morphologic characterization of the pathway of transferrin endocytosis after conversion with Epstein-Barr virus (Correction), 3918 and recycling in human KB cells, 175 Detection of an Epstein-Barr virus-associated membrane antigen in Cytosolic calcium regulates epidermal growth factor endocytosis in rat Epstein-Barr virus-transformed nonproducer cells by leukocyte pancreas and cultured fibroblasts, 461 migration inhibition and blocking antibody, 4178 Biologically active synthetic fragments of epidermal growth factor: Identification and mapping of polypeptides encoded by the P3HR-1 strain Localization of a major receptor-binding region, 1351 of Epstein-Barr virus, 4183 Progesterone receptor subunits are high-affinity substrates for Identification of Epstein-Barr virus sequences that encode a nuclear phosphorylation by epidermal growth factor receptor, 1654 antigen expressed in latently infected lymphocytes, 4373 Polypeptide hormone regulation of gene transcription: Specific 5' Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor genomic sequences are required for epidermal growth factor and CR2, 4510 phorbol ester regulation of prolactin gene expression, 2975 Expression of a nuclear and a cytoplasmic Epstein-Barr virus early Neuroblastoma cells produce transforming growth factors during antigen after DNA transfer: Cooperation of two distant parts of the exponential growth in a defined hormone-free medium, 4085 genome for expression of the cytoplasmic antigen, 4568 a-Factor-directed synthesis and secretion of mature foreign proteins in Antibodies against a synthetic peptide identify the Epstein-Barr virus- Saccharomyces cerevisiae, 4642 determined nuclear antigen, 4652 Epidermal growth factor inhibits the synthesis of the nuclear protein No evidence for differences in the Epstein-Barr virus genome carried in cyclin in A431 human carcinoma cells, 4848 Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from Neoplastic human fibroblast proteins are related to epidermal growth the same patients, 4930 factor precursor, 5360 Infection of B lymphocytes by a human herpesvirus, Epstein-Barr virus, Serum-free growth of human mammary epithelial cells: Rapid clonal is blocked by calmodulin antagonists, 4955 growth in defined medium and extended serial passage with pituitary Expression of Epstein-Barr virus (EBV) DNA and cloned DNA extract, 5435 fragments in human lymphocytes following Sendai virus envelope- Evidence for physiological function of epidermal growth factor: mediated gene transfer, 5926 Pregestational sialoadenectomy of mice decreases milk production and A membrane protein encoded by Epstein-Barr virus in latent growth- increases offspring mortality during lactation period, 6059 transforming infection, 7207 Inhibition of epidermal growth factor-induced mitogenesis by amiloride nuclear and an analog: Evidence against a requirement for Na+/H+ U2 region of Epstein-Barr virus DNA may encode Epstein-Barr exchange, 6762 antigen 2, 7632 Vaccinia virus 19-kilodalton protein: Relationship to several mammalian Error discrimination proteins, including two growth factors, 7363 Molecular mechanisms of manganese mutagenesis, 7378 Epidermal growth factor rapidly induces a redistribution of transferrin erythro-9-[3-(2-Hydroxynonyl)Jadenine receptor pools in human fibroblasts, 7456 erythro-9-[3-(2-Hydroxynonyl)]adenine is an effective inhibitor of cell Specific stimulation of actin gene transcription by epidermal growth motility and actin assembly, 6044 factor and cycloheximide, 7476 Erythroblast Epidermal growth factor receptor src- andfps-containing avian sarcoma viruses transform chicken erythroid Phorbol esters potentiate tyrosine phosphorylation of epidermal growth cells, 7122 factor receptors in A431 membranes by a calcium-independent Erythrocyte mechanism, 2298 Nuclear matrix DNA from chicken erythrocytes contains /3-globin gene Down-regulation of the epidermal growth factor receptor in KB cells is sequences, 304 due to receptor internalization and subsequent degradation in Detection of erythrocyte membrane proteins, sialoglycoproteins, and lysosomes, 2384 lipids in the same polyacrylamide gel using a double-staining Tumor promoters block tyrosine-specific phosphorylation of the technique, 1733 epidermal growth factor receptor, 3034 Defining erythrocyte internal labeling by phosphorylation, 2767 Antibodies to two defined regions of the transforming protein pp60Sc Potential use of biaromatic L-phenylalanyl derivatives as therapeutic interact specifically with the epidermal growth factor receptor kinase agents in the treatment of sickle cell disease, 3190. system, 5911 Goblin (ankyrin) in striated muscle: Identification of the potential Characterization of epidermal growth factor receptor gene expression in membrane receptor for erythroid spectrin in muscle cells, 3292 malignant and normal human cell lines, 7308 Phorbol ester induces desensitization of adenylate cyclase and Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on phosphorylation of the P3-adrenergic receptor in turkey receptor binding of epidermal growth factor in the hepatic plasma erythrocytes, 4316 membrane of rat, guinea pig, mouse, and hamster, 7407 Catalase: A tetrameric enzyme with four tightly bound molecules of Epidermis NADPH, 4343 Keratolinin: The soluble substrate of epidermal transglutaminase from Protein 4.1: Its association with the human erythrocyte membrane, 4404 human and bovine tissue, 238 Localization of senescent cell antigen on band 3, 5753 Intracellular free magnesium in erythrocytes of essential hypertension: Epididymis Relation to blood pressure and serum divalent cations, 6511 Expression of pro-opiomelanocortin-like gene in the testis and Differentiation of human erythroid cells is associated with increased 0- epididymis, 5672 glycosylation of the major sialoglycoprotein, glycophorin A, 6752 Epilepsy Mammalian brain and erythrocyte carboxyl methyltransferases are similar Kindling alters the calcium/calmodulin-dependent phosphorylation of enzymes that recognize both D-aspartyl and L-isoaspartyl residues in synaptic plasma membrane proteins in rat hippocampus, 1253 structurally altered protein substrates, 7757 Epistasis Human antibodies to a Mr 155,000 Plasmodium falciparuin antigen Cultural and biological evolutionary processes: Gene-culture efficiently inhibit merozoite invasion, 7912 disequilibrium, 1604 Erythrocyte enzyme Epithelial cell line Identification of thymidine nucleotidase and deoxyribonucleotidase Epithelial mouse mammary cell line exhibiting normal morphogenesis in activities among normal isozymes of 5'-nucleotidase in human vivo and functional differentiation in vitro, 3756 erythrocytes, 588 Epithelium Erythrocyte membrane Endocytosis in alveolar type II cells: Effect of charge and size of ATP-dependent asymmetric distribution of spin-labeled phospholipids in tracers, 6054 the erythrocyte membrane: Relation to shape changes, 3751 Epitope A dual role for the Ca2+-requiring proteinase in the degradation of Method to map antigenic determinants recognized by monoclonal hemoglobin by erythrocyte membrane proteinases, 6714 antibodies: Localization of a determinant of virus neutralization of the Erythrocyte protein 2.1 feline leukemia virus envelope protein gp7O, 3675 A structural model of human erythrocyte band 2.1: Alignment of chemical Use of peptide synthesis to probe viral antigens for epitopes to a and functional domains, 4095 resolution of a single amino acid, 3998 Erythroid burst-forming unit Circumsporozoite gene of Plasmodium cynomolgi (Gombak): cDNA Embryonic -* fetal Hb switch in humans: Studies on erythroid bursts cloning and expression of the repetitive circumsporozoite epitope, 7520 generated by embryonic progenitors from yolk sac and liver, 2416 e chain Erythroleukemia cell Expression of a biologically active fragment of human IgE E chain in Long-term cultivation and differentiation of human erythroleukenmia cells Escherichia coli, 5369 in a protein-free chemically defined medium, 453 8072 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984)

Accurate initiation of human E-globin RNA synthesis by Escherichia coli DNA sequence of the carA gene and the control region of carAB: RNA polymerase in isolated nuclei of K562 erythroleukemia cells, 4051 Tandem promoters, respectively controlled by arginine and the Stable transfer and expression of exogenous human globin genes in pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase human erythroleukemia (K562) cells, 5315 in Escherichia coli K-12, 4134 DNA methylation and regulation of the human P-globin-like genes in Multiple regulatory signals in the control region of the Escherichia coli mouse erythroleukemia cells containing human chromosome 11, 6618 carAB operon, 4139 Erythropoiesis : New possibly involved in end-turnover Mouse yolk sac and intraembryonic tissues produce factors able to elicit of tRNA, 4290 differentiation of erythroid burst-forming units and colony-forming Primary structure of the Escherichia coli ribonucleoside diphosphate units, respectively, 1453 reductase operon, 4294 Embryonic -i fetal Hb switch in humans: Studies on erythroid bursts An Escherichia coli mutant deficient in pyruvate oxidase activity due to generated by embryonic progenitors from yolk sac and liver, 2416 altered phospholipid activation of the enzyme, 4348 Erythropoietin Cell-division control in Escherichia coli: Specific induction of the SOS Mouse yolk sac and intraembryonic tissues produce factors able to elicit function SfiA protein is sufficient to block septation, 4490 differentiation of erythroid burst-forming units and colony-forming Distribution of DNA insertion element IS5 in natural isolates of units, respectively, 1453 Escherichia coli, 4500 Cloning and expression of human erythropoietin cDNA in Escherichia Molecular analysis of the recF gene of Escherichia coli, 4622 coli, 2708 Multiple joined genes prevent product degradation in Escherichia Specific binding of erythropoietin to spleen cells infected with the anemia coli, 4627 strain of Friend virus, 7574 Sequence homology between two membrane transport ATPases, the Kdp- ATPase of Escherichia coli and the Ca'+-ATPase of sarcoplasmic Escherichia coli reticulum, 4746 Attenuation of the iivB operon by amino acids reflecting substrates or Isolation of the Escherichia coli iron superoxide dismutase gene: products of the ilvB gene product, 76 Evidence that intracellular superoxide concentration does not regulate Evidence for clinal population structure in Escherichia coli, 198 oxygen-dependent synthesis of the manganese superoxide tRNAget gene in the leader region of the nusA operon in Escherichia dismutase, 4970 coli, 409 Sensory transduction in Escherichia coli: Regulation of the demethylation Protein HU in the enzymatic replication of the chromosomal origin of rate by the CheA protein, 5061 Escherichia coli, 424 Transfer RNA mischarging mediated by a mutant Escherichia coli Use of the Escherichia coli lac repressor and operator to control gene glutaminyl-tRNA synthetase, 5076 expression in Bacillus subtilis, 439 Staphylococcal enterotoxin A gene is associated with a variable genetic Pronounced structural similarities between the small subunit ribosomal element, 5179 RNA genes of wheat mitochondria and Escherichia coli, 493 Expression of normal and transforming H-ras genes in Escherichia coli Correction of complex heteroduplexes made of mouse H-2 gene and purification of their encoded p21 proteins, 5305 sequences in Escherichia coli K-12, 503 Expression of a biologically active fragment of human IgE E chain in Escherichia coli mutants suppressing replication-defective mutations of Escherichia coli, 5369 the ColEl plasmid, 550 Translational regulation of the L11 ribosomal protein operon of High-level production of biologically active human a1-antitrypsin in Escherichia coli: Analysis of the mRNA target site using Escherichia coli, 669 oligonucleotide-directed mutagenesis, 5389 Aminomalonic acid: Identification in Escherichia coli and atherosclerotic Role of mRNA translational efficiency in bovine growth hormone plaque, 722 expression in Escherichia coli, 5403 Major heat shock gene of Drosophila and the Escherichia coli heat- Processing of complex DNA heteroduplexes in Escherichia coli and Cos-1 inducible dnaK gene are homologous, 848 monkey cells, 5792 Functional molecular weight of the lac carrier protein from Escherichia Synthesis of a gene for human growth hormone and its expression in coli as studied by radiation inactivation analysis, 1021 Escherichia coli, 5956 RNase H confers specificity in the dnaA-dependent initiation of In vitro regulation of phage X cII gene expression by Escherichia coli replication at the unique origin of the Escherichia coli chromosome in integration host factor, 6009 vivo and in vitro, 1040 Envelope proteins of human T-cell leukemia virus: Expression in Amino acid sequence homology among the major outer membrane Escherichia coli and its application to studies of env gene proteins of Escherichia coli, 1048 functions, 6202 Virus-plasmid interactions: Mutants of bacteriophage T3 that abortively Synthesis in Escherichia coli of human adenovirus type 12 transforming infect plasmid F-containing (F+) strains of Escherichia coli, 1465 proteins encoded by early region 1A 13S mRNA and 12S mRNA, 6300 groEL and dnaK genes of Escherichia coli are induced by UV irradiation Heat shock regulatory gene htpR influences rates of protein degradation and nalidixic acid in an htpR+-dependent fashion, 1499 and expression of the lon gene in Escherichia coli, 6647 Construction of shuttle vectors capable of conjugative transfer from A gene regulating the heat shock response in Escherichia coli also affects Escherichia coli to nitrogen-fixing filamentous cyanobacteria, 1561 proteolysis, 6779 Molecular model for elongation of the murein sacculus of Escherichia Heat shock response regulatory gene (htpR) of Escherichia coli is coli, 1844 required for growth at high temperature but is dispensable at low Differential antibody screening of cloned Plasmodium falciparum temperature, 6803 sequences expressed in Escherichia coli: Procedure for isolation of Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 defined antigens and analysis of human antisera, 2456 protein produced in Escherichia coli, 6953 Cloning, nucleotide sequence, and expression in Escherichia coli of the Escherichia coli translational initiation factor IF3: A unique case of exotoxin A structural gene of Pseudcmonas aeruginosa, 2645 translational regulation, 7061 Cloning and expression of human erythropoietin cDNA in Escherichia Plasmid transfer from Escherichia coli to Bacteroides fragilis: Differential coli, 2708 expression of antibiotic resistance phenotypes, 7203 Stimulation of recombination between homologous sequences on plasmid Identification and characterization of a new transcriptional termination DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2- factor from Escherichia coli, 7373 acetylaminofluorene, 2831 Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in Escherichia coli mutants suppressing replication-defective mutations of vitro, 7397 the ColEl plasmid (Correction), 2944 In vitro translocation of bacterial proteins across the plasma membrane of Properties of a human immunoglobtilin E-chain fragment synthesized in Escherichia coli, 7421 Escherichia coli, 2955 Involvement of the activated form of RecA protein in SOS mutagenesis Internal homologies in the two aspartokinase-homoserine and stable DNA replication in Escherichia coli, 7539 dehydrogenases of Escherichia coli K-12, 3019 Essential site for growth rate-dependent regulation within the Escherichia Generation of antibody activity from immunoglobulin polypeptide chains coli gnd structural gene, 7669 produced in Escherichia coli, 3273 Protein export in Escherichia coli requires a soluble activity, 7737 Structure of the Trg protein: Homologies with and differences from other Mechanism of toxin secretion by Vibrio cholerae investigated in strains sensory transducers of Escherichia coli, 3287 harboring plasmids that encode heat-labile enterotoxins of Escherichia Biologically active protease of foot and mouth disease virus is expressed coli, 7752 from cloned viral cDNA in Escherichia coli, 3351 The absence of RNase H allows replication of pBR322 in Escherichia coli The rnh gene is essential for growth of Escherichia coli, 3447 Streptokinase: Cloning, expression, and excretion by Escherichia mutants lacking DNA polymerase I, 7845 coli, 3557 A new class of Escherichia coli recBC mutants: Implications for the role Identification and expression in Escherichia coli of merozoite stage- of RecBC enzyme in homologous recombination, 7850 specific genes of the human malarial parasite Plasmodium Esophus falciparum, 3690 Intramural mechanism of esophageal peristalsis: Roles of cholinergic and Rapid mutational analysis of regulatory loci in Escherichia coli K-12 using noncholinergic nerves, 3595 bacteriophage M13, 3801 Estradiol Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from Estradiol feedback effects on the a-subunit mRNA in the sheep pituitary Escherichia coli DNA requires the uvrA, uvrB, and urvC gene gland: Correlation with serum and pituitary luteinizing hormone products, 3821 concehtrations, 1322 Tandem promoters preceding the gene for the Ml RNA component of Identification of 17f-estradiol as the estrogenic substance in Escherichia ccii . 3959 Saccharomyces cerevisiae, 4722 Induction of specific Escherichia coli genes by sublethal treatments with Estradiol receptor alkylating agents, 4110 Calmodulin-stimulated phosphorylation of 17,f-estradiol receptor on Regulation of the araC gene of Escherichia coli: Catabolite repression, tyrosine, 5921 autoregulation, and effect of araBAD expression, 4120 Estrogen Selective isolation of cosmid clones by homologous recombination in Direct arterial vascularization of estrogen-induced prolactin-secreting Escherichia coli, 4129 anterior pituitary tumors, 4549 Biological Sciences Subject Index Proc. NatL. Acad ScL USA 81 (1984) 8073

Activation of pS2 gene transcription is a primary response to estrogen in Exocytosis the human breast cancer cell line MCF-7, 6344 Rapid release of galactose-terminated ligands after endocytosis by hepatic Estrogen receptor parenchymal cells: Evidence for a role of carbohydrate structure in the Preferential binding of estrogen-receptor complex to a region containing release of internalized ligand from receptor, 466 the estrogen-dependent hypomethylation site preceding the chicken Epidermal growth factor rapidly induces a redistribution of transferrin vitellogenin II gene, 429 receptor pools in human fibroblasts, 7456 Identification of 17p-estradiol as the estrogenic substance in Exon Saccharomyces cerevisiae, 4722 The structure of the human tissue-type plasminogen activator gene: Injection of partially purified estrogen receptor protein from Xenopus Correlation of intron and exon structures to functional and structural liver nuclei into oocytes activates the silent vitellogenin locus, 5777 domains, 5355 Isolated uterine nuclei and cytosol receptors of aged rats exhibit impaired Exon, noncoding estrogenic stimulation of RNA polymerase II, 7481 Nucleotide sequence 5' of the chicken c-myc coding region: Localization Ethanol of a noncoding exon that is absent from myc transcripts in most avian Molecular abnormality of an inactive aldehyde dehydrogenase variant leukosis virus-induced lymphomas, 4697 commonly found in Orientals, 258 Nucleotide sequence 5' of the chicken c-myc coding region: Localization Catabolite repression of chloroplast development in Euglena, 2786 of a noncoding exon that is absent from myc transcripts in most avian Toward an analogue of alcoholism in mice: Scale factors in the leukosis virus-induced lymphomas (Correction), 7258 model, 3543 Exonuclease Ethanolamline Mammalian DNA polymerase a holoenzymes with possible functions at Serum-free growth of human mammary epithelial cells: Rapid clonal the leading and lagging strand of the replication fork, 3993 growth in defined medium and extended serial passage with pituitary A separate editing exonuclease for DNA replication: The e subunit of extract, 5435 Escherichia coli DNA polymerase III holoenzyme, 7747 Ether lipid Exoribonucdease Tumorigenicity of cell lines with altered lipid composition, 7622 Ribonuclease T: New exoribonuclease possibly involved in end-turnover L-Ethionine of tRNA, 4290 The persistence of maternal inheritance in Chlamydomonas despite Exotoxin A hypomethylation of chloroplast DNA induced by inhibitors, 3438 Cloning, nucleotide sequence, and expression in Escherichia coli of the 04-Ethyldeoxythymldne exotoxin A structural gene of Pseudomonas aeruginosa, 2645 04-Ethyldeoxythymidine, but not 06-ethyldeoxyguanosine, accumulates Cellular ADP-ribosyltransferase with the same mechanism of action as in hepatocyte DNA of rats exposed continuously to diphtheria toxin and Pseudomonas toxin A, 2703 diethylnitrosamine, 1692 Experimental diabetic neuropathy Ethylene Prevention of some electrophysiologic and biochemical abnormalities with Lipid peroxidation forms ethylene from 1-aminocyclopropane-1- oxygen supplementation in experimental diabetic neuropathy, 6894 carboxylic acid and may operate in leaf senescence, 1724 Expression plasmid Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic Molecular cloning of human terminal deoxynucleotidyltransferase, 4363 acid during its conversion to ethylene, 3059 Extinction Eugkna Periodicity of extinctions in the geologic past, 801 Catabolite repression of chloroplast development in Euglena, 2786 Fossil vertebrates from Antigua, Lesser Antilles: Evidence for late Holocene human-caused extinctions in the West Indies, 4448 Are DNA spacers relics of gene amplification events?, 1768 Repeatability of taxon longevity in successive foraminifera radiations and Eocytes: A new ribosome structure indicates a kingdom with a close a theory of random appearance and extinction, 5478 relationship to eukaryotes, 3786 Extinction, behavioral Eukaryotic expression vector Behavioral and neurochemical differentiation of specific projections in Expression of hepatitis B virus S gene by herpes simplex virus type 1 the septal-hippocampal cholinergic pathway of the rat, 1880 vectors carrying a- and a-regulated gene chimeras, 5867 Extracellular matrix Eukaryotic initiation factor 2 von Willebrand protein binds to extracellular matrices independently of Mechanism of translational control by partial phosphorylation of the a collagen, 471 subunit of eukaryotic initiation factor 2, 352 Hepatocyte proliferation in vitro: Its dependence on the use of serum-free Protein synthesis in rabbit reticulocytes: A study of the mechanism of hormonally defined medium and substrata of extracellular matrix, 1411 action of the protein factor RF that reverses protein synthesis inhibition In vitro transformation of mesenchymal cells derived from embryonic of heme-deficient reticulocyte lysates, 5379 muscle into cartilage in response to extracellular matrix components of Distribution of reversing factor in reticulocyte lysates during active bone, 3419 protein synthesis and on inhibition by heme deprivation or double- Variants of the cell recognition site of fibronectin that retain attachment- stranded RNA, 6998 promoting activity, 5985 Eutherian Extrapeptide Eutherian-like reproductive specializations in a viviparous reptile, 4860 Molecular cloning and nucleotide sequence of cDNA for mRNA of Evolution mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex, 4647 Periodicity of extinctions in the geologic past, 801 Eye Cultural and biological evolutionary processes: Gene-culture Requirement for protein synthesis in the regulation of a circadian rhythm disequilibrium, 1604 by serotonin, 7637 A model for the origin of biological catalysis, 1751 Eye lens On the evolution of altruism by kin selection, 1754 Sequence of a complete chicken 6-crystallin cDNA, 2611 Are DNA spacers relics of gene amplification events?, 1768 Nondisulfide polymerization of y- and P-crystallins in the human A model for the origin of biological catalysis (Correction), 4599 lens, 2878 Chromosomal mapping of a middle-repetitive DNA sequence in a cluster Lens transglutaminase selects specific 3-crystallin sequences as of five species of Hawaiian Drosophila, 7146 substrate, 7017 The molecular clock may be an episodic clock, 8009 F-Crystallin family of the mouse lens: Structural and evolutionary Evolution, prebiotic relationships, 7762 Self-organization in macromolecular systems: The notion of adaptive Eyelid response value, 6068 Classical conditioning of the rabbit eyelid response increases glutarnate Evolutionary conservation receptor binding in hippocampal synaptic membranes, 2548 Isolation and nucleotide sequence of the gene encoding human rhodopsin, 4851 F' plasmid Evolutionary landscape recA-independent recombination of y8 termini and at IS3 producing Evolutionary principles for polynomial models of frequency-dependent inverted repetition in F' plasmids, 4869 selection, 2840 F protein Evolutionary tree Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of An evolutionary tree relating eight alphaviruses, based on amino-terminal human respiratory syncytial virus, 7683 sequences of their glycoproteins, 4702 Facilitated transport Excision Evidence for rotational contribution to protein-facilitated proton Unusual alleles of recB and recC stimulate excision of inverted repeat transport, 1710 transposons TnlO and Tn5, 824 Facilitation Excision nuclease Branch-specific heterosynaptic facilitation in Aplysia siphon sensory Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in cells, 2577 vitro, 7397 Factor IX Excited state Regional localization on the human X chromosome and polymorphism of Fluorescence quantum yield of visual pigments: Evidence for the coagulation factor IX gene (hemophilia B locus), 498 subpicosecond isomerization rates, 4790 Activation of factor IX bound to cultured bovine aortic endothelial Exercise cells, 913 Biochemical and physiological correlates of deer mouse a-chain Factor V hemoglobin polymorphisms, 5484 Coagulation factors V and VIII and ceruloplasmin constitute a family of Exocrine organ structurally related proteins, 6934 Monoclonal antibodies as probes for unique antigens in secretory cells of Factor VIII mixed exocrine organs, 4419 Coagulation factors V and VIII and ceruloplasmin constitute a family of structurally related proteins, 6934 8074 Biological Sciences Subject Index Proc. NatL Acad ScL USA 81 (1984)

Factor X Fertility control Characterization of a cDNA coding for human factor X, 3699 RU 486: A steroid with antiglucocorticosteroid activity that only Familial dysautonomia disinhibits the human pituitary-adrenal system at a specific time of Structural gene for /3-nerve growth factor not defective in familial day, 3879 dysautonomia, 4213 Fertilization Familial hypercholesterolemia Time and voltage windows for reversing the electrical block to Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in fertilization, 1436 familial hypercholesterolemia heterozygotes: Effects on cholesterol A Ca2+-activated channel from Xenopus laevis oocyte membranes balance, 2538 reconstituted into planar bilayers, 5155 Assignment of the human gene for the low density lipoprotein receptor to Fertilization in vitro chromosome 19: Synteny of a receptor, a ligand, and a genetic Birth of rhesus monkey infant after in vitro fertilization and nonsurgical disease, 2826 embryo transfer, 2218 Modulation of human lymphocyte responses by low density lipoproteins a-Fetoprotein (LDL): Enhancement but not immunosuppression is mediated by LDL Serum a-fetoprotein levels in human disease: Perspective from a highly receptors, 4539 specific monoclonal radioimmunoassay, 3869 Receptor-mediated endocytosis of low density lipoprotein: Somatic cell Differential DNase I sensitivity of the albumin and a-fetoprotein genes in mutants define multiple genes required for expression of surface- chromatin from rat tissues and cell lines, 5031 receptor activity, 5454 Locus unlinked to a-fetoprotein under the control of the murine raf and Fasting R#fgenes, 5523 Lipoprotein lipase is produced, regulated, and functional in rat Fever brain, 7604 Induction of y-interferon activity by elevated temperatures in human B- Fat cells lymphoblastoid cell lines, 4033 Trifluoperazine inhibits insulin action on glucose metabolism in fat cells Fiber polypeptide without affecting inhibition of lipolysis, 327 Altered mRNA splicing in monkey cells abortively infected with human Fatty acid adenovirus may be responsible for inefficient synthesis of the virion Interactions of myristic acid with bovine serum albumin: A '3C NMR fiber polypeptide, 4023 study, 3718 Fibrin Development of encephalopathic features similar to Reye syndrome in Localization of a fibrin -chain polymerization site within segment Thr- rabbits, 6169 374 to Glu-396 of human fibrinogen, 5980 DNA damage related to increased hydrogen peroxide generation by Fibrinogen hypolipidemic drug-induced liver peroxisomes, 7827 Potential basis for regulation of the coordinately expressed fibrinogen Fatty acid binding protein genes: Homology in the 5' flanking regions, 2313 Cloning of a cDNA encoding rat intestinal fatty acid binding protein, 313 Fibrinopeptide A binds Gly-Pro-Arg-Pro, 4339 Fc fragment ADP-dependent common receptor mechanism for binding of von Fc-mediated binding of IgG to vimentin-type intermediate filaments in Willebrand factor and fibrinogen to human platelets, 4935 vascular endothelial cells, 3103 Localization of a fibrin y-chain polymerization site within segment Thr- Fc receptor 374 to Glu-396 of human fibrinogen, 5980 Selective killing of Fc-receptor-bearing tumor cells through endocytosis Fibrinopeptide A of a drug-carrying immune complex, 1445 Fibrinopeptide A binds Gly-Pro-Arg-Pro, 4339 Properties of a human immunoglobulin E-chain fragment synthesized in Fibroblast Escherichia coli, 2955 Exposure of nondividing populations of primary human fibroblasts to UV The increase in intracellular free calcium associated with IgGy2b/-yl Fc (254 nm) radiation induces a transient enhancement in capacity to receptor-ligand interactions: Role in phagocytosis, 5430 repair potentially lethal cellular damage, 781 The increase in intracellular free calcium associated with IgGy2b/y1 Fc Increased adhesiveness of Down syndrome fetal fibroblasts in vitro, 2426 receptor-ligand interactions: Role in phagocytosis (Correction), 7258 Monensin-induced inhibition of cell spreading in normal and dystrophic Feedback human fibroblasts, 4960 Motor deficits in patients with large-fiber sensory neuropathy, 979 Abnormal collagen metabolism in cultured skin fibroblasts from patients i-Aminobutyric acid acts at axon terminals of turtle photoreceptors: with Duchenne muscular dystrophy, 5130 Difference in sensitivity among cell types, 7961 Biological activities of v-myc and rearranged c-myc oncogenes in rat Feeder layer fibroblast cells in culture, 5758 Polycyclic aromatic hydrocarbon mutagenesis of human epidermal Interactions between human tumor cells and fibroblasts stimulate keratinocytes in culture, 7802 hyaluronate synthesis, 6767 Feeding behavior -Epidermal growth factor rapidly induces a redistribution of transferrin Neophobia in the foraging-site selection of a neotropical migrant bird: An receptor pools in human fibroblasts, 7456 experimental study, 3778 Fibroblast behavior Feline leukemia virus Monitoring fibroblast behavior in tissue culture with an applied electric Appearance of cytotoxic antibody to viral gp7O on feline lymphoma cells field, 3761 (FL-74) in cats during ex vivo immunoadsorption therapy: Quantitation, Fibroblast growth factor characterization, and association with remission of disease and Purification and characterization of acidic fibroblast growth factor from disappearance of viremia, 3516 bovine brain, 357 Method to map antigenic determinants recognized by monoclonal Isolation and partial molecular characterization of pituitary fibroblast antibodies: Localization of a determinant of virus neutralization of the growth factor, 5364 feline leukemia virus envelope protein gp70, 3675 Isolation of brain fibroblast growth factor by heparin-Sepharose affinity Remission of leukemia and loss of feline leukemia virus in cats injected chromatography: Identity with pituitary fibroblast growth factor, 6963 with Staphylococcus protein A: Association with increased circulating Fibroblast growth regulator interferon and complement-dependent cytotoxic antibody, 6471 Growth control in cultured 3T3 fibroblasts: Neutralization and Feline sarcoma virus identification of a growth-inhibitory factor by a monoclonal Nucleotide sequence of the feline retroviral oncogene v-fms shows antibody, 2107 unexpected homology with oncogenes encoding tyrosine-specific Fibroblast protein protein kinases, 85 Neoplastic human fibroblast proteins are related to epidermal growth Transforming potential of a human protooncogene (c-fps/fes) locus, 3039 factor precursor, 5360 Female-sterile mutants Fibroin Mutants suppressing in trans chorion gene amplification in Contact points between transcription machinery and the fibroin gene Drosophila, 3773 promoter deduced by functional tests of single-base substitution Fermentation mutants, 1394 Mechanism of cytoplasmic pH regulation in hypoxic maize root tips and Natural fibroin genes purified without using cloning procedures from its role in survival under hypoxia, 3379 fibroin-producing and -nonproducing tissues reveal indistinguishable Ferredoxin structure and function, 1644 Spectroscopic studies of ferricyanide oxidation of Azotobacter vinelandii Fibronectin ferredoxin I, 1931 Structural analysis of fibronectin and its collagen-binding fragment from Photoreduction of ferredoxin with various electron donors: Support for several cell lines, 28 the Z scheme of photosynthetic electron transport, 2070 von Willebrand protein binds to extracellular matrices independently of Ferricyanide collagen, 471 Spectroscopic studies of ferricyanide oxidation of Azotobacter vinelandii A single rat fibronectin gene generates three different mRNAs by ferredoxin I, 1931 of a complex exon, 5140 Ferritin Variants of the cell recognition site of fibronectin that retain attachment- Isolation and characterization of a cDNA clone for human ferritin heavy promoting activity, 5985 chain, 4751 Filamentous phage Ferrocytochrome c Major coat protein and single-stranded DNA-binding protein of Single catalytic site model for the oxidation of ferrocytochrome c by filamentous virus PO, 699 mitochondrial cytochrome c oxidase, 347 Increased intracellular concentration of an initiator protein markedly Fertility reduces the minimal sequence required for initiation of DNA Characterization of a membrane antigen from rabbit testis and sperm synthesis, 1336 isolated by using monoclonal antibodies and effect of its antiserum on Fliopodia fertility, 857 Neuronal growth cones: Specific interactions mediated by filopodial insertion and induction of coated vesicles, 1849 Biological Sciences Subject Index Proc. NatL. Acad. Sci USA 81 (1984) 8075

Finite-element model Formate acetyltransferase Simple finite-element model accounts for wide range of cardiac Post-translational activation introduces a free radical into pyruvate dysrhythmias, 233 formate-lyase, 1332 5' untranslated sequence N-Formylkynurenlne 5' untranslated sequences are required for the translational control of a hterfreron ? blocks the growth of Toxoplasma gondii in human fibroblasts yeast regulatory gene, 5096 by inducing the host cells to degrade tryptophan, 908 Flagellum Forskolin Analysis of the pleiotropic regulation of flagellar and chemotaxis gene Binding of [3HJforskolin to rat brain membranes, 5081 expression in Caulobacter crescentus by using plasmid Fossil complementation, 1341 Repeatability of taxon longevity in successive foraminifera radiations and Isolation of flagellated membrane vesicles from Caulobacter crescentus a theory of random appearance and extinction, 5478 cells: Evidence for functional differentiation of polar membrane Fragile X domains, 3409 Cytological mapping of the human glucose--phosphate dehydrogenase Flavin gene distal to the fragile-X site suggests a high rate of meiotic The possibility that the spectrum of intermediate two, seen in the course recombination across this site, 7855 of reaction of flavoenzyme phenol hydroxylases, may be attributable to Frameshift iminol isomers of a flavin-derived 6-arylamino-5-oxo(3H,5H)uracil, 332 Molecular model of ribosome frameshifting, 5797 Characterization and postulated structure of the primary emitter in the bacterial luciferase reaction, 2990 Frameshlft mutation Use of riboflavin-binding protein to investigate steric and electronic Demonstration of the production of frameshift and base-substitution relationships in flavin mutations by quasipalindromic DNA sequences, 5528 analogs and models, 4246 Suppressor sufJ: A novel type of tRNA mutant that induces translational Flip-flop regulation frameshifting, 6105 Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: Comparison of normal and transformed cells, 3133 Affecting gene expression by altering the length and sequence of the 5' Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: leader, 7698 Comparison of normal and transformed cells (Correction), 6548 Free energy Flooding tolerance The free energy of DNA supercoiling is enthalpy-determined, 1312 Cytoplasmic as a Free energy coupling acidosis determinant of flooding intolerance in A quantitative model for the cooperative mechanism of human plants, 6029 hemoglobin, 1093 Fluence Order of free energy couplings between ligand binding and protein Phototropic response of the stage I Phycomyces sporangiophore to a pulse of blue light, subunit association in hemoglobin, 7098 7103 Free energy transduction N-2-Fluorenylacetamide Soliton-assisted unidirectional circulation in a biochemical cycle, 4386 Normal liver chromatin contains a firmly bound and larger protein related to the principal cytosolic target a Free radical polypeptide of hepatic Post-translational activation introduces a free radical into pyruvate carcinogen, 2092 formate-lyase, 1332 Fluorescein isothiocyanate Protease inhibitors reduce the frequency of spontaneous chromosome Conformational changes in the intestinal brush border sodium-glucose abnormalities in cells from patients with Bloom syndrome, 1827 cotransporter labeled with fluorescein isothiocyanate, 2223 Active oxygen acts as a promoter of transformation in mouse embryo Fluorescence C3H/10T2/C18 fibroblasts, 2085 Calculation of the polarized fluorescence from a labeled muscle fiber, 145 Interaction of the 2,6-dimethoxysemiquinone and ascorbyl free radicals Tumor cell proteinase visualization and quantification using a fluorescent with Ehrlich ascites cells: A probe of cell-surface charge, 2088 transition-state analog probe, 1135 Detection of superoxide generated by endothelial cells, 7269 Fluorescence decay Freezing Picosecond fluorescence decay of tryptophans in myoglobin, 4399 Lamellar-to-hexogonalll phase transitions in the plasma membrane of Fluorescence quantum yield isolated protoplasts after freeze-induced dehydration, 6373 Fluorescence quantum yield of visual pigments: Evidence for Friend erythroleukemia cell subpicosecond isomerization rates, 4790 Continuous suppression of globin gene expression and differentiation of Flux Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) Interference of GTP hydrolysis in the mechanism of microtubule despite the loss of PMA binding sites by down regulation, 2075 assembly: An experimental study, 771 Differentiation of Friend erythroleukemia cells induced by Fly benzodiazepines, 3770 Hormonal control of eclosion of flies from the puparium, 1457 Friend erythroleukemia virus Fodrin Characterization of leukemogenic virus produced by a new line of Friend Brain fodrin: Substrate for calpain I, an endogenous calcium-activated erythroleukemia virus-transformed cells, 1831 protease, 3572 Specific binding of erythropoietin to spleen cells infected with the anemia Folate-binding protein strain of Friend virus, 7574 Glycine N-methyltransferase is a folate binding protein of rat liver Friend virus cytosol, 3631 A unique sequence related to the ecotropic murine leukemia virus is Follitropin associated with the Fv-4 resistance gene, 834 Synthesis and biological activity of human inhibin-like peptide- Frontal gland (1-31), 5399 Soldier formation regulated by a primer pheromone from the soldier Food intake frontal gland in a higher termite, Nasutitermes lujae, 7665 Reduction in the incidence of radiation-induced tumors in rats after 2,6-bisphosphate restriction of food intake, 7596 Regulation of pea seed pyrophosphate-dependent phosphofructokinase: Food restriction Evidence for interconversion of two molecular forms as a glycolytic Effects of food restriction on aging: Separation of food intake and regulatory mechanism, 5051 adiposity, 1835 Fruit fly Food size See Drosophila Body size and food size in freshwater zooplankton, 6427 Fruiting body Food web cAMP pulses coordinate morphogenetic movement during fruiting body Trophic links of community food webs, 4105 formation of Dictyostelium minutum, 2122 Foot-and-mouth disease virus Fucosyltransferase Biologically active protease of foot and mouth disease virus is expressed Biochemical evidence that secretor gene, Se, is a structural gene from cloned viral cDNA in Escherichia coli, 3351 encoding a specific fucosyltransferase, 4193 Use of peptide synthesis to probe viral antigens for epitopes to a Fucus resolution of a single amino acid, 3998 Isoelectric focusing of plant cell membranes, 4804 Foraging Fujinand sarcoma virus Neophobia in the foraging-site selection of a neotropical migrant bird: An Decrease of tyrosine-O-sulfate-containing proteins found in rat fibroblasts experimental study, 3778 infected with Rous sarcoma virus or Fujinami sarcoma virus, 3695 Foraminifera Functional coupling Repeatability of taxon longevity in successive foraminifera radiations and Influence of the P3-adrenergic receptor concentration on functional a theory of random appearance and extinction, 5478 coupling to the adenylate cyclase system, 4637 Forebrain Fungus Cerebellum mediates modality-specific modulation of sensory responses Cross-reactions of polysaccharides of fungi, molds, and yeasts in anti- of midbrain and forebrain in rat, 2917 pneumococcal and other antisera, 5247 Forest Fungus, phytopathogenic Guatemalan forest synthesis after Pleistocene aridity, 4856 Cloning and structure determination of cDNA for cutinase, an enzyme Forgetting involved in fungal penetration of plants, 3939 Hippocampal denervation causes rapid forgetting of olfactory information 2-(2-Furoyl)-4(5)-(2-furanyl)-1H-imidazole in rats, 5885 Aging of proteins: Isolation and identification of a fluorescent Formaldehyde activation factor chromophore from the reaction of polypeptides with glucose, 2684 Formaldehyde activation factor, tetrahydromethanopterin, a coenzyme of Fusarium methanogenesis, 1976 Cloning and structure determination of cDNA for cutinase, an enzyme involved in fungal penetration of plants, 3939 8076 Biological Sciences Subject Index Proc. NatL. Acad ScL USA 81 (1984)

Fushi taram Gastric gland Structural relationships among genes that control development: Sequence Na+-H+ exchange in gastric glands as measured with a cytoplasmic- homology between the Antennapedia, Ultrabithorax, and fushi tarazu trapped, fluorescent pH indicator, 7436 loci of Drosophila, 4115 Gastrin Fusion glycoprotein Structure of a human gastrin gene, 1067 Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of Gastrin and cholecystokinin in pituitary neurons, 1902 human respiratory syncytial virus, 7683 Structural analysis of the gene encoding human gastrin: The large intron Fusion protein contains an Alu sequence, 4662 Fusion protein of the paramyxovirus simian virus 5: Nucleotide sequence Gastrin-releasing peptide of mRNA predicts a highly hydrophobic glycoprotein, 6706 Cloning and characterization of cDNAs encoding human gastrin-releasing A membrane protein encoded by Epstein-Barr virus in latent growth- peptide, 5699 transforming infection, 7207 Gastrointestinal cancer Analysis of Sendai virus mRNAs with cDNA clones of viral genes and Characterization of monoclonal antibodies to serum sequences of biologically important regions of the fusion protein, 7732 galactosyltransferase, 2529 Gastropod G-C-G-C Snail shape and growth rates: Evidence for plastic shell allometry in In Z-DNA the sequence G-C-G-C is neither methylated by Hha I Littorina littorea, 811 methyltransferase nor cleaved by Hha I restriction endonuclease, 3268 Gaucher disease GABA Cross-reacting material in Gaucher disease fibroblasts, 6506 See y-Aminobutyric acid GDP exchange factor system Mechanism of translational control by partial phosphorylation of the a GABAergicIntrinsic GABAergic system of adrenal chromaffin cells, 3218 subunit of eukaryotic initiation factor 2, 352 Gadolinium Gene Ad Tubular arrays of the actin-DNase I complex induced by Cell-type-specific cDNA probes and the murine I region: The localization gadolinium, 1669 and orientation of A., 2194 Galactosamine Gene abi Structure of human hemopexin: O-Glycosyl and N-glycosyl sites and An 8-kilobase abl RNA transcript in chronic myelogenous leukemia, 5648 unusual clustering of tryptophan residues, 2021 Gene activation Galactosamine receptor Activation of a chicken embryonic globin gene in adult erythroid cells by Rapid release of galactose-terminated ligands after endocytosis by hepatic 5-azacytidine and sodium butyrate, 3954 parenchymal cells: Evidence for a role of carbohydrate structure in the Mouse c-mos oncogene activation is prevented by upstream release of internalized ligand from receptor, 466 sequences, 7817 Galactose Gene Adhl Rapid release of galactose-terminated ligands after endocytosis by hepatic DNA insertion in the first intron of maize Adhl affects message levels: parenchymal cells: Evidence for a role of carbohydrate structure in the Cloning of progenitor and mutant Adhl alleles, 4125 release of internalized ligand from receptor, 466 Gene adr -Galactosidase Calcium-binding protein, parvalbumin, is reduced in mutant mammalian Intracellular targeting and import of an FI-ATPase ,-subunit-0- muscle with abnormal contractile properties, 4814 galactosidase hybrid protein into yeast mitochondria, 3983 Gene aid Expression of f3-galactosidase controlled by a nitrogenase promoter in Induction of specific Escherichia coli genes by sublethal treatments with stem nodules of Aeschynomene scabra, 5806 alkylating agents, 4110 Anti-mRNA: Specific inhibition of translation of single mRNA Gene a molecules, 7525 Separation of sequences defining basal expression from those conferring (8-Galactosidase, evolved a gene recognition within the regulatory domains of herpes simplex Topological repression of gene activity by a transposable element, 6115 virus 1 a genes, 4065 j3-Galactosidase hybrid protein Gene ami In vivo formation of gene fusions encoding hybrid ,-galactosidase Hyperrecombination at a specific DNA sequence in pneumococcal proteins in one step with a transposable Mu-lac transducing phage, 535 transformation, 5184 Amino terminus of the yeast GAL4 gene product is sufficient for nuclear Gene amplification localization, 5951 Primary structure and transcription of an amplified genetic locus: The ,-Galactoside transport CUP) locus of yeast, 337 Purified reconstituted lac carrier protein from Escherichia coli is fully Molecular cloning and expression of the mouse ornithine decarboxylase functional, 1629 gene, 540 Galactosyltransferase Are DNA spacers relics of gene amplification events?, 1768 Characterization of monoclonal antibodies to serum Development of methotrexate resistance in a human squamous cell galactosyltransferase, 2529 carcinoma of the head and neck in culture, 2873 Galago Isolation of cloned cDNA encoding mammalian ornithine Effects of monocular deprivation on the lateral geniculate nucleus in a decarboxylase, 3645 primate, 2255 Mutants suppressing in trans chorion gene amplification in Gallopamil Drosophila, 3773 Charge movement in skeletal muscle fibers paralyzed by the calcium- Aberrant expression of an amplified c-myb oncogene in two cell lines entry blocker D600, 2582 from a colon carcinoma, 4534 Enhanced expression of the human gene N-myc consequent to Gamete motility amplification of DNA may contribute to malignant progression of Search, encounter rates, and the evolution of anisogamy, 6078 neuroblastoma, 4940 Gametogenesis Development of methotrexate resistance in a human squamous cell The persistence of maternal inheritance in Chlamydomonas despite carcinoma of the head and neck in culture (Correction), 5006 hypomethylation of chloroplast DNA induced by inhibitors, 3438 Chromosomal organization of the human dihydrofolate reductase genes: w-radiation Dispersion, selective amplification, and a novel form of A molecular approach to leukemogenesis: Mouse lymphomas contain an polymorphism, 5170 activated c-ras oncogene, 202 Inducible expression of a cloned heat shock fusion gene in sea urchin ry5 resolvase embryos, 7490 Cleavage of the site-specific recombination protein y8 resolvase: The Gene ANBI smaller of two fragments binds DNA specifically, 2001 Oxygen regulation of anaerobic and aerobic genes mediated by a common vS transposon factor in yeast, 6129 Topological repression of gene activity by a transposable element, 6115 Gene ara Ganglion Regulation of the araC gene of Escherichia coli: Catabolite repression, Developing dorsal root ganglion neurons require trophic support from autoregulation, and effect of araBAD expression, 4120 their central processes: Evidence for a role of retrogradely transported An operator at -280 base pairs that is required for repression of araBAD nerve growth factor from the central nervous system to the operon promoter: Addition of DNA helical turns between the operator periphery, 6245 and promoter cyclically hinders repression, 5017 Ganglion cell Gene bz Activity and the control of ganglion cell death in the rat retina, 5589 Cloning of the bronze locus in maize by a simple and generalizable procedure using the transposable controlling element Activator IgM in a human neuropathy related to paraproteinemia binds to a (Ac), 3825 carbohydrate determinant in the myelin-associated glycoprotein and to Gene c-erb-A a ganglioside, 1225 A human c-erbA oncogene homologue is closely proximal to the Tunicamycin blocks neuritogenesis and glucosamine labeling of chromosome 17 breakpoint in acute promyelocytic leukemia, 4495 gangliosides in developing cerebral neuron cultures, 5638 Cellular homologs of the avian erythroblastosis virus erb-A and erb-B Localization of the gangliosides GD2 and GD3 in adhesion plaques and on genes are syntenic in mouse but asyntenic in man, 4874 the surface of human melanoma cells, 5767 Gene c-erb-B Gap junction Cellular homologs of the avian erythroblastosis virus erb-A and erb-B Determination of synaptic phenotype: Insulin and cAMP independently genes are syntenic in mouse but asyntenic in man, 4874 initiate development of electrotonic coupling between cultured Characterization of epidermal growth factor receptor gene expression in sympathetic neurons, 6235 malignant and normal human cell lines, 7308 Biological Sciences Subject Index Proc. NatL Acad ScL USA 81 (1984) 8077

Gene c-fos DNA sequence transfer between two high-cysteine chorion gene families Human c-fos oncogene mapped within chromosomal region 14q21 in the silkmoth Bombyx mori, 4452 q31, 5826 Hyperrecombination at a specific DNA sequence in pneumococcal Gene c-fps/fes transformation, 5184 Transforming potential of a human protooncogene (c-fpslfes) locus, 3039 Gene CUPI Gene c-Ha-ras-l Primary structure and transcription of an amplified genetic locus: The Molecular cloning and the total nucleotide sequence of the human c-Ha- CUP] locus of yeast, 337 ras-1 gene activated in a melanoma from a Japanese patient, 4771 Gene CYC Gene c-K-ras Differential regulation of the duplicated isocytochrome c genes in Isolation of transforming sequences of two human lung carcinomas: yeast, 4475 Structural and functional analysis of the activated c-K-ras Upstream activation sites of the CYC) gene of Saccharomyces cerevisiae oncogenes, 71 are active when inverted but not when placed downstream of the Gene c-mos "TATA box", 7860 Mouse c-mos oncogene activation is prevented by upstream Gene dam sequences, 7817 DNA methylation pattern is determined by the intracellular level of the Gene c-myb methylase, 3278 Aberrant expression of an amplified c-myb oncogene in two cell lines Gene DC-3, from a colon carcinoma, 4534 Cloning and sequence analysis of the human major histocompatibility Gene c-myc complex gene DC-3p, 5199 Products of a reciprocal chromosome translocation involving the c-myc Gene Ddr gene in a murine plasmacytoma, 829 Mutations in the dopa decarboxylase gene affect learning in Proviral deletions and oncogene base-substitutions in insertionally Drosophila, 3577 mutagenized c-myc alleles may contribute to the progression of avian Gene deletion bursal tumors, 843 Patterns of polymorphism and linkage disequilibrium suggest independent Hemizygous interstitial deletion of chromosome 15 (band D) in three origins of the human growth hormone gene cluster, 6085 translocation-negative murine plasmacytomas, 1159 Gene Selective reduction of c-myc mRNA in Daudi cells by human , Major heat shock gene of Drosophila and the Escherichia coli heat- interferon, 1747 inducible dnaK gene are homologous, 848 Proviruses are adjacent to c-myc in some murine leukemia virus-induced RNase H confers specificity in the dnaA-dependent initiation of lymphomas, 2097 replication at the unique origin of the Escherichia coli chromosome in Translocated c-myc oncogene of Burkitt lymphoma is transcribed in vivo and in vitro, 1040 plasma cells and repressed in lymphoblastoid cells, 3170 groEL and dnaK genes of Escherichia coli are induced by UV irradiation Induction of plasmacytoid differentiation by phorbol ester in B-cell and nalidixic acid in an htpR+-dependent fashion, 1499 lymphoma cell lines bearing 8;14 translocations, 3547 A separate editing exonuclease for DNA replication: The E subunit of Nucleotide sequence 5' of the chicken c-myc coding region: Localization Escherichia coli DNA polymerase III holoenzyme, 7747 of a noncoding exon that is absent from myc transcripts in most avian Gene dosage leukosis virus-induced lymphomas, 4697 Regional assignment of the structural gene for human a-L- Translocation and rearrangement of c-myc into immunoglobulin a heavy , 1169 chain locus in primary cells from acute lymphocytic leukemia, 5514 Gene duplication Specific regulation of c-myc oncogene expression in a murine B-cell Cardiac a- and P-myosin heavy chain genes are organized in lymphoma, 5546 tandem, 2626 Biological activities of v-myc and rearranged c-myc oncogenes in rat Internal homologies in the two aspartokinase-homoserine fibroblast cells in culture, 5758 dehydrogenases of Escherichia coli K-12, 3019 Activation of a translocated c-myc gene: Role of structural alterations in Complete amino acid sequence of human plasma P2-glycoprotein I, 3640 the upstream region, 6798 Structural model of human ceruloplasmin based on internal triplication, Viral integration near c-myc in 10-20% of MCF 247-induced AKR hydrophilic/hydrophobic character, and secondary structure of lymphomas, 6808 domains, 4761 A 14;18 and an 8;14 chromosome translocation in a cell line derived from Human metallothionein genes are clustered in chromosome 16, 5494 an acute B-cell leukemia, 7166 Human alcohol dehydrogenase: Structural differences between the , and Nucleotide sequence 5' of the chicken c-myc coding region: Localization y subunits suggest parallel duplications in isoenzyme evolution and of a noncoding exon that is absent from myc transcripts in most avian predominant expression of separate gene descendants in livers of leukosis virus-induced lymphomas (Correction), 7258 different mammals, 6320 The protein encoded by the human proto-oncogene c-myc, 7742 Spontaneous deletions and duplications of sequences in the genome of Gene c-ras cowpox virus, 6817 A molecular approach to leukemogenesis: Mouse lymphomas contain an Internal duplication in human a, and P, interferons, 7171 activated c-ras oncogene, 202 Gene E2a Gene c-src DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' Overexpression of the c-src protein does not induce transformation of region inactivate the E2a gene of adenovirus type 2, 2950 NIH 3T3 cells, 7071 Transformation properties of type 5 adenovirus mutants that differentially Gene car express the ElA gene products, 5734 DNA sequence of the carA gene and the control region of carAB: Gene Eco gpt Tandem promoters, respectively controlled by arginine and the Introduction of a selectable gene into different animal tissue by a pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase retrovirus recombinant vector, 7151 in Escherichia coli K-12, 4134 Gene ent Multiple regulatory signals in the control region of the Escherichia coli Staphylococcal enterotoxin A gene is associated with a variable genetic carAB operon, 4139 5179 Regulation of Cat) gene expression in the scutellum of maize during early element, sporophytic development, 4903 Gene env Avian sarcoma virus gag and env gene structural protein precursors Gene cat contain a common amino-terminal sequence, 362 Selective expression of a plasmid cat gene at a late stage of Bacillus Envelope proteins of human T-cell leukemia virus: Expression in subtilis sporulation, 3457 Escherichia coli and its application to studies of env gene Regulation of Cat) gene expression in the scutellum of maize during early functions, 6202 sporophytic development, 4903 Serological cross-reactivity between envelope gene products of type I and Gene CDC8 type II human T-cell leukemia virus, 7579 Yeast gene CDC8 encodes thymidylate kinase and is complemented by Gene evolution herpes thymidine kinase gene TK, 5821 Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino Gene che acid segment with amphipathic helical potential, 5021 Sensory transduction in Escherichia coli: Regulation of the demethylation Gene expression rate by the CheA protein, 5061 Modification of DNA by reducing sugars: A possible mechanism for Gene cII nucleic acid aging and age-related dysfunction in gene expression, 105 In vitro regulation of phage X cII gene expression by Escherichia coli Mice completely suppressed for the expression of immunoglobulin K integration host factor, 6009 chain, 211 Kinetic analysis of mutations affecting the clI activation site at the PRE Primary structure and transcription of an amplified genetic locus: The promoter of bacteriophage X, 6432 CUP) locus of yeast, 337 Gene cluster Regulated expression of a human interferon gene in yeast: Control by Clustered genes for human U2 RNA, 3811 phosphate concentration or temperature, 367 Gene control of amino acid biosynthesis Cell cycle regulation of human histone H1 mRNA, 434 5' untranslated sequences are required for the translational control of a Use of the Escherichia coli lac repressor and operator to control gene yeast regulatory gene, 5096 expression in Bacillus subtilis, 439 Gene conversion High-level production of biologically active human a1-antitrypsin in Correction of complex heteroduplexes made of mouse H-2 gene Escherichia coli, 669 sequences in Escherichia coli K-12, 503 Variant antigen genes of Trypanosoma brucei: Genomic alteration of a Origin of the ,B3-globin gene in Blacks: The contribution of recurrent spliced leader orphon and retention of expression-linked copies during mutation or gene conversion or both, 853 differentiation, 684 Structure and comparison of the oxytocin and vasopressin genes from Brain-specific genes have identifier sequences in their introns, 713 rat, 2006 Insulin-induced reactivation of an inactive herpes simplex thymidine Evolution of multigene families under interchromosomal gene kinase gene, 838 conversion, 37% 8078 Biological Sciences Subject Index Proc. NatL. Acad. Sci USA 81 (1984)

Induction of two genes by glucose starvation in hamster fibroblasts, 988 Differential expression of mRNAs for a- and ,8-tubulin during Generation of a TnS promoter probe and its use in the study of gene differentiation of the parasitic protozoan Leishmania mexicana, 5782 expression in Caulobacter crescentus, 1035 Construction of Tn5 lac, a transposon that fuses lacZ expression to Molecular analysis of the Neurospora qa-) regulatory region indicates exogenous promoters, and its introduction into Myxococcus that two interacting genes control qa gene expression, 1174 xanthus, 5816 Adenovirus early region 1A protein activates transcription of a nonviral Expression of hepatitis B virus S gene by herpes simplex virus type 1 gene introduced into mammalian cells by infection or transfection, 1193 vectors carrying a- and /-regulated gene chimeras, 5867 Expression of an immunoglobulin heavy chain gene transfected into Synthesis of a gene for human growth hormone and its expression in lymphocytes, 1292 Escherichia coli, 5956 Nucleotide sequence surrounding transcription initiation site of xyLABC Cell-cycle-specific cDNAs from mammalian cells temperature sensitive operon on TOL plasmid of Pseudomonas putida, 1688 for growth, 6004 Albumin extinction without methylation of its gene, 1738 In vitro regulation of phage X clI gene expression by Escherichia coli Murine leukemia virus sequences are encoded in the murine major integration host factor, 6009 histocompatibility complex, 1804 Topological repression of gene activity by a transposable element, 6115 Chromosomal location of the co-expressed human skeletal and cardiac The simian virus 40 minimal origin and the 72-base-pair repeat are actin genes, 1813 required simultaneously for efficient induction of Whte gene expression Evidence for a human histone gene cluster containing H2B and H2A with large tumor antigen, 6335 pseudogenes, 1936 Triplication of a four-gene set during evolution of the goat 83-globin locus A unique mechanism regulating gene expression: Translational inhibition produced three genes now expressed differentially during by a complementary RNA transcript (micRNA); 1966 development, 6589 Stimulation of simian virus 40 late gene expression by simian virus 40 Integration-specific retrovirus expression in embryonal carcinoma tumor antigen, 2040 cells, 6627 Functional and inducible expression of a transfected murine class II Transcriptional activation of the rat liver tyrosine aminotransferase gene major histocompatibility complex gene, 2045 by cAMP, 6637 Continuous suppression of globin gene expression and differentiation of Expression of the sis gene by endothelial cells in culture and in vivo, 6772 Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) Activation of a translocated c-myc gene: Role of structural alterations in despite the loss of PMA binding sites by down regulation, 2075 the upstream region, 6798 Structure, expression, and mutation of the hypoxantliine Characterization and regulation in the expression of a gene coding for the phosphoribosyltransferase gene, 2147 intermediate filament protein desmin, 6909 High-level expression of a chenrically synthesized gene for human Functions of purified ElA protein microinjected into mammalian interfdron--y using a prokaryotic expression vector, 2290 cells, 6988 Proteins related to the mouse L-cell major heat shock protein are Nucleotide sequence of the spoOB gene of Bacillus subtilis and regulation synthesized in the absence of heat shock gene expression, 2317 of its expression, 7012 Tempolal expression of late histone messenger RNA in the sea urchin Two regulatory elements for immunoglobulin K light chain gene Lytechinus pictus, 2411 expression, 7041 Ty-mediated gene expression of the LYS2 and HIS4 genes of Overexpression of the c-src protein does not induce transformation of Saccharomyces cerevisiae is controlled by the same SPT genes, 2431 NIH 3T3 cells, 7071 Expressioh of immunoglobulin heavy chain at a high level in the absence Construction of a retrovirus capable of transducing and expressing genes of a proposed immunoglobulin enhancer element in cis, 2452 in multipotential embryonic cells, 7137 Control of biologically active interleukin 2 messenger RNA formation in Expression of cellular oncogenes during embryonic and fetal development induced human lymphocytes, 2601 of the mouse, 7141 Mapping of DNase I-hypersensitive sites in the upstream DNA of human Introduction of a selectable gene into different animal tissue by a embryonic e-globin gene in K562 leukemia cells, 2718 retrovirus recombinant vector, 7151 Organ-specifit nuclear RNAs in tobacco, 2801 Enhancer-dependent expression of human K immunoglobulin genes MAL6 of Sacclaromyces: A complex genetic locus containing three introduced into mouse pre-B lymphocytes by electroporation, 7161 genes required for maltose fermentation, 2811 Denervation of rat adrenal glands markedly increases preproenkephalin Variant antigen genes of Trypanosoma brucei: Genomic alteration of a mRNA, 7221 spliced leader orphon and retention of expression-linked copies during Characterization of epidermal growth factor receptor gene expression in differentiation (Correction), 2944 malignant and normal human cell lines, 7308 Structure and expression of a pea nuclear gene encoding a chlbrophyll Changing patterns of gene expression during sporulation in yeast, 7323 alb-binding polypeptide, 2960 An immunological method for detecting gene expression in yeast Polypeptide hormone regulation of gene transcription: Specific 5' colonies, 7426 genomic sequences are required for epidermal growth factor and Inducible expression of a cloned heat shock fusion gene in sea urchin phorbol ester regulation of prolactin gene expression, 2975 - embryos, 7490 Expression and regulation of chicken actin genes introduced into niouse Affecting gene expression by altering the length and sequence of the 5' myogenic and nonmyogenic cells, 2980 leader, 7698 Selective expression of a plasmid cat gene at a late stage of Bacillus Expression of the /-nerve growth factor gene correlates with the density subtilis sporulation, 3457 of sympathetic innervation in effector organs, 7951 Extrapancreatic insulin gene expression in the fetal rat, 3635 Gene family Separation of sequences defining basal expression from those conferring See Multigene family a gene recognition within the regulatory domains of herpes simplex DNA sequence transfer between two high-cysteine chorion gene families virus 1 a genes, 4065 ih the silkmoth Bombyx mori, 4452 A unique mechanism regulating gene expression: Translational inhibition Gene flow by a complementary RNA transcript (micRNA) (Correction), 4240 Mitochondrial gene flow, 1764 Glucocorticoid-mediated induction of a,-acid glycoprotein: Evidence for GeneJfs hormone-regulated RNA processing 4241 src- andfps-containing avian sarcoma viruses transform chicken erythroid A -globin gene, inactive in the K5 2 leukemic cell, functions normally in cells, 7122 a heterologous expression system, 4485 Expression of a nuclear and a cytoplasmic Epstein-Barr virus early Gene, fused antigen after DNA transfer: Cooperation of two distant parts of the Multiple joined genes prevent product degradation in Escherichia genome for expression of the cytoplasmic antigen, 4568 coli, 4627 Cell-specified expression of a selectable hybrid gene, 4657 Gene fusion Rapid induction of a specific nuclear mRNA precursor by thyroid In vivo formation of gene fusions encoding hybrid P3-galactosidase hormone, 4687 proteins in one step with a transposable Mu-lac transducing phage, 535 In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac Gyp+ Hereditary persistence of fetal hemoglobin: Cosmid cloning and bacteriophage containing a plasmid replicon, 1480 identification of a specific mutation 5' to the y gene, 4894 Intracellular targeting and import of an F1-ATPase P-subunit-13- Regulation of Cat] gene expression in the scutellum of maize during early galactosidase hybrid protein into yeast mitochondria, 3983 sporophytic development, 4903 Rapid purification of a cloned gene product by genetic fusion and site- Enhanced expression of the human gene N-myc consequent to specific proteolysis, 4692 amplification of DNA may contribute to malignant progression of Secretion of foreign proteins from Saccharomyces cerevisiae directed by neuroblastoma, 4940 5330 Differential DNase I sensitivity of the albumin and a-fetoprotein genes in a-factor gene fusions, chromatin from rat tissues and cell lines, 5031 Gene Fv.4 The role of a signaling protein in bacterial sensing: Behavioral effects of A unique sequence related to the ecotropic murine leukemia virus is increased gene expression, 5056 associated with the Fv-4 resistance gene, 834 Cyclosporin A inhibits T-cell growth factor gene expression at the level of Gene gag mRNA transcription, 5214 Avian-sarcoma virus gag and env gene structural protein precursors Stable transfer and expression of exogenous human globin genes in contain a common amino-terminal sequence, 362 human erythroleukemia (K562) cells, 5315 Human placental syncytiotrophoblastic Mr 75,000 polypeptide defined by Role of mRNA translational efficiency in bovine growth hormone antibodies to a synthetic peptide based on a cloned human endogenous expression in Escherichia coli, 5403 retroviral DNA sequence, 6197 Mouse kidney and submaxillary gland renin genes differ in their 5' Gene gal putative regulatory sequences, 5489 Demonstration of two operator elements in gal: In vitro repressor binding Expression of the Thy-1 glycoprotein gene by DNA-mediated gene studies, 6100 transfer, 5532 Genetic properties and chromatin structure of the yeast gal regulatory Specific regulation of c-myc oncogene expression in a murine B-cell element: An enhancer-like sequence, 7865 lymphoma, 5546 Gene GAL4 Injection of partially purified estrogen receptor protein from Xenopus Amino terminus of the yeast GAL 4 gene product is sufficient for nuclear liver nuclbi into oocytes activates the silent vitellogenin locus, 5777 localization, 5951 Biological Sciences Subject Index Proc. NatL Acad. Sci USA 81 (1984) 8079 Gene GCN4 Gene /dl 5' untranslated sequences are required for the translational control of a Receptor-mediated endocytosis of low density lipoprotein: Somatic cell yeast regulatory gene, 5096 mutants define multiple genes required for expression of surface- Evidence for translational regulation of the activator of general amino receptor activity, 5454 acid control in yeast, 6442 Gene kxc4 Gene gnd Autodigestion of lexA and phage X repressors, 1375 Essential site for growth rate-dependent regulation within the Escherichia Rapid mutational analysis of regulatory loci in Escherichia coli K-12 using coli gnd structural gene, 7669 bacteriophage M13, 3801 Gene gpi Gene Ion Cell-specified expression of a selectable hybrid gene, 4657 Heat shock regulatory gene htpR influences rates of protein degradation Gene gro and expression of the ion gene in Escherichia coli, 6647 groEL and dnaK genes of Escherichia coli are induced by UV irradiation A gene regulating the heat shock response in Escherichia coli also affects and nalidixic acid in an htpR+-dependent fashion, 1499 proteolysis, 6779 Gene H-2 Gene larP Correction of complex heteroduplexes made of mouse H-2 gene Interaction of the bacteriophage P1 recombinase Cre with the sequences in Escherichia coli K-12, 503 recombining site loxP, 1026 Eukaryotic chromosome transfer: Linkage of the murine major Gen Isp histocompatibility complex to an inserted dominant selectable Nucleotide sequence of the Escherichia coli prolipoprotein signal marker, 4879 peptidase (1sp) gene, 3708 A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 Gene lax mutant, 5204 Identification of genes and gene products necessary for bacterial Genomic constitution of an H-2:Tla variant leukemia, 6447 bioluminescence, 4154 Gene H-2Dq Gene LYS2 Primary structural evidence that the H-2Dq region encodes at least three Ty-mediated gene expression of the LYS2 and HIS4 genes of distinct gene products: Dq, Lq, and Rq, 2499 Saccharomyces cerevisiae is controlled by the same SPT genes, 2431 Gene H-ras Gene MAL6 Analysis of the transforming potential of the human H-ras gene by 4fAL6 of Saccharomyces: A complex genetic locus containing three random mutagenesis, 4008 genes required for maltose fermentation, 2811 Expression of normal and transforming H-ras genes in Escherichia coli Generation of deletions in pneumococcal mal genes cloned in Bacillus and purification of their encoded p21 proteins, 5305 subtilis, 5189 A position 12-activated H-ras oncogene in all HS578T mammary Gene mapping carcinosarcoma cells but not normal mammary cells of the same Molecular hybridization under conditions of high stringency permits patient, 5384 cloned DNA segments containing reiterated DNA sequences to be Gene HIS4 assigned to specific chromosomal locations, 520 Ty-mediated gene expression of the LYS2 and HIS4 genes of Chromosome assignments of four mouse cellular homologs of sarcoma Saccharomyces cerevisiae is controlled by the same SPT genes, 2431 and leukemia virus oncogenes, 525 ATP-binding sites in the membrane components of the histidine Regional assignment of the structural gene for human a-L- permease, a periplasmic transport system, 7333 iduronidase, 1169 Gene HLA Chromosomal assignment of the gene for human elongation factor 2, 3158 A human autosomal locus maps near the HLA Localization of cytochrome P1-450 and P3-450 genes to'mduse cluster, 3167 chromosome 9, 3163 Isolation of HLA locus-specific DNA probes from the 3Y-untranslated Strategies for multilocus linkage analysis in humans, 3443 region, 5175 Eukaryotic chromosome transfer: Linkage of the murine major Gene Hsp7O histocompatibility complex to an inserted dominant selectable Major heat shock gene of Drosophila and the Escherichia coli heat- marker, 4879 inducible dnaK gene are homologous, 848 Directional cloning of DNA fragments at a large distance from an initial Gene htpR probe: A circularization method, 6812 Heat shock regulatory gene htpR influences rates of protein degradation Gene masr and expression of the ion gene in Escherichia coli, 6647 Two nuclear mutations that block mitochondrial protein import in A gene regulafing the heat shock response in Escherichia coli also affects yeast, 4819 proteolysis, 6779 Gene mdx Heat shock response regulatory gene (htpR) of Escherichia coli is X chromosome-linked muscular dystrophy (mdx) in the mouse, 1189 required for growth at high temperature but is dispensable at low Gene Mep-I temperature, 6803 Mep.4 gene controlling a kidney metalloendopeptidase is linked to the GeneIIn major histocompatibility complex in mice, 5542 Detection in vivo of a new gene product (gene III) of cauliflower mosaic Gene ner virus, 6608 Mercuric ion-resistance operons of plasmid R100 and transposon Tn501: Gene ilvB The beginning of the operon including the regulatory region and the Attenuation of the i/vB operon by amino acids reflecting substrates or first two structural genes, 5975 products of the ilvB gene product, 76 Mov-13 Gene incA fGeneInsertion of retrovirus into the first intron of al(I) collagen gene leads to Plasmid P1 replication: Negative control by repeated DNA embryonic lethal mutation in mice, 1504 sequences, 6456 Gene mu-2 Geneinduction mu-2: Mutator gene in Drosophila that potentiates the induction of Induction of specific Escherichia coli genes by sublethal treatments with terminal deficiencies, 6090 alkylating agents, 4110 Gene myc Geneinf Extreme instability of myc mRNA in normal and transformed human Sequence of the initiation factorIF2 gene: Unusual protein features and cells, 7046 homologies with elongation factors, 7787 Gene N Gene INOI nusB: A protein factor necessary for transcription antitermination in vitro Isolation of the yeast INOJ gene: Located on an autonomously by phage X N gene product, 6305 replicating plasmid, the gene is fully regulated, 3816 Gene N-myc Gene Wi Enhanced expression of the human gene N-myc consequent to The retroviruspo/ gene encodes a product required for DNA integration: amplification of DNA may contribute to malignant progression of Identification of a retrovirus int locus, 7885 neuroblastoma, 4940 GeneIVa2 Gene N-rns Proximal and distal domains that control in vitro transcription of the Mechanism of activation of an N-ras oncogene of SW-1271 human lung adenovirusIVa2 gene, 6290 carcinoma cells, 3670 Gene lac Gene neo Use of the Escherichia coli lac repressor and operator to control gene Cell-specified expression of a selectable hybrid gene, 4657 expression in Bacillus subtilis, 439 Construction of a retrovirus capable of transducing and expressing genes Possible ideal lac operator: Escherichia coli lac operator-like sequences in multipotential embryonic cells, 7137 from eukaryotic genomes lack the centralG-C pair, 1624 GenenWf Cloning and expression of the gene for bacteriophage 17 RNA Plasmid-linked nif and "nod" genes in fast-growing rhizobia that nodulate polymerase, 2035 Glycine max, Psophocarpus tetragonolobus, and Vigna Construction of TnS lac, a transposon that fuses lacZ expression to unguiculata, 3093 exogenous promoters, and its introduction into Myxococcus Expression of P-galactosidase controlled by a nitrogenase promoter in xanthus, 5816 stem nodules of Aeschynomene scabra, 5806 Antitermination of transcription from an Escherichia coli ribosomal RNA Structural genes of dinitrogenase and dinitrogenase reductase are promoter, 6789 transcribed from two separate promoters in the broad host range Genelan cowpea Rhizobium strain IRc78, 7358 Extention of bacteriophage X host range: Selection, cloning, and Geneand characterization ofa constitutive Xreceptor gene, 6080 Primary structure of the Escherichia coli riboriucleoside diphosphate Gene irtB reductase operon, 4294 Intragenic regions required for LamB export, 3830 Gene nus gene in the leader region of the nusA operon in Escherichia tRNA4etcoli, 409 8080 Biological Sciences Subject Index Proc. NatL. Acad. Sci. USA 81 (1984)

Formation of termination-resistant transcription complex at phage X nut A new class of Escherichia coli recBC mutants: Implications for the role locus: Effects of altered translation and a ribosomal mutation, 3612 of RecBC enzyme in homologous recombination, 7850 nusB: A protein factor necessary for transcription antitermination in vitro Gene red by phage X N gene product, 6305 Evidence for inclusion of regions of nonhomology in heteroduplex Gene nut products of bacteriophage X recombination, 7180 Formation of termination-resistant transcription complex at phage X nut Gene regulation locus: Effects of altered translation and a ribosomal mutation, 3612 Inhibition of malignant transformation in vitro by inhibitors of poly(ADP- Gene omp ribose) synthesis, 243 Amino acid sequence homology among the major outer membrane Mutational analysis of a regulatory region in bacteriophage X that has proteins of Escherjchia coli, 1048 overlapping signals for the initiation of transcription and A unique mechanism regulating gene expression: Translational inhibition translation, 555 by a complementary RNA transcript (micRNA), 1966 Demonstration of transcriptional regulation of specific genes by A unique mechanism regulating gene expression: Translational inhibition phytochrome action, 1112 by a complementary RNA transcript (micRNA) (Correction), 4240 Potential basis for regulation of the coordinately expressed fibrinogen Gene onc genes: Homology in the 5' flanking regions, 2313 Nucleotide sequence of avian carcinoma virus MH2: Two potential onc Cardiac a- and f-myosin heavy chain genes are organized in genes, one related to avian virus MC29 and the other related to murine tandem, 2626 sarcoma virus 3611, 3000 Structure of the 5' ends of immunoglobulin genes: A novel conserved Gene organization sequence, 2650 The structure of the human tissue-type plasminogen activator gene: Translocated c-myc oncogene of Burkitt lymphoma is transcribed in Correlation of intron and exon structures to functional and structural plasma cells and repressed in lymphoblastoid cells, 3170 domains, 5355 Copper metallpthionein of yeast, structure of the gene, and regulation of Gene on expression, 3332 Enhanced recombination between Xplac5 and F421ac: Identification of Synthesis of cholera toxin is positively regulated at the transcriptional cis- and trans-acting factors, 7500 level by toxR, 3471 Correlation of lac operator DNA imino proton exchange kinetics with its Gene oriC function, 3665 Protein HU in the enzymatic replication of the chromosomal origin of Isolation of the yeast INOI gene: Located on an autonomously Escherichia coli, 424 replicating plasmid, the gene is fully regulated, 3816 Gene per Inhibition of protein synthesis stimulates the transcription of human 13- Molecular genetics of a biological clock in Drosophila, 2142 interferon genes in Chinese hamster ovary cells, 3964 Gene pil Altered mRNA splicing in monkey cells abortively infected with human Pilus genes of Neisseria gonorrheae: Chromosomal organization and adenovirus may be responsible for inefficient synthesis of the virion DNA sequence, 6110 fiber polypeptide, 4023 Gene PiZ Regulation of the araC gene of Escherichia coli: Catabolite repression, Monoclonal antibody specific for the mutant PiZ a1-antitrypsin and its autoregulation, and effect of araBAD expression, 4120 application in an ELISA procedure for identification of PiZ gene DNA insertion in the first intron of maize Adhl affects message levels: carriers, 5690 Cloning of progenitor and mutant Adhl alleles, 4125 Gene pol Detecting protein-DNA interactions in vivo: Distribution of RNA A mutant murine leukemia virus with a single missense codon in pol is polymerase on specific bacterial genes, 4275 defective in a function affecting integration, 6461 Differences in keratin synthesis between normal epithelial cells and The retrovirus po gene encodes a product required for DNA integration: squamous cell carcinomas are mediated by vitamin A, 4280 Identification of a retrovirus int locus, 7885 Primary structure of the Escherichia coli ribonucleoside diphosphate Gene pS2 reductase operon, 4294 Activation of pS2 gene transcription is a primary response to estrogen in Individual products of the adenovirus 12S and 13S Ela mRNAs stimulate the human breast cancer cell line MCF-7, 6344 viral Ella and EIII expression at the transcriptional level, 4381 Gene psbA Differential regulation of the duplicated isocytochrome c genes in Herbicide resistance in Chlamydomonas reinhardtii results from a yeast, 4475 mutation in the chloroplast gene for the 32-kilodalton protein of Defining a bacteriophage T4 late promoter: Bacteriophage T4 gene 55 photosystem II, 3617 protein suffices for directing late promoter recognition, 5101 Oxygen regulation of anaerobic and aerobic genes mediated by a common Gene pyr factor in yeast, 6129 Location of amino acid alterations in mutants of aspartate Characterization of the Bacillus subtilis tryptophan promoter region, 6315 transcarbamoylase: Structural aspects of interallelic DNA methylation and regulation of the human ,3-globin-like genes in complementation, 115 mouse erythroleukemia cells containing human chromosome 11, 6618 Gene qa Extreme instability of myc mRNA in normal and transformed human Molecular analysis of the Neurospora qa-) regulatory region indicates cells, 7046 that two interacting genes control qa gene expression, 1174 Essential site for growth rate-dependent regulation within the Escherichia Gene rqf coli gnd structural gene, 7669 Locus unlinked to a-fetoprotein under the control of the murine raf and Gene rep Rif genes, 5523 Replication of the broad host range plasmid RSF1010: Requirement for Gene ras three plasmid-encoded proteins, 654 Autophosphorylation of v-Ha-ras p21 is modulated by amino acid residue Gene Rif 12, 2674 Locus unlinked to a-fetoprotein under the control of the murine raf and Monoclonal antibodies of predefined specificity detect activated ras gene Rif genes, 5523 expression in human mammary and colon carcinomas, 5227 rn/ Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 Gene molecules, 5704 The rnh gene is essential for growth of Escherichia coli, 3447 A product of yeast RAS2 gene is a guanine nucleotide binding Gene rop protein, 6924 cis-acting mutations that affect rop protein control of plasmid copy Isolation and characterization of a cDNA clone for the y subunit of number, 4465 bovine retinal , 6948 Gene rrn Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 Antitermination of transcription from an Escherichia coli ribosomal RNA protein produced in Escherichia coli, 6953 promoter, 6789 Gene rbc Regulation of ribosomal RNA promoters with a synthetic lac Cotranscription of genes encoding the small and large subunits of operator, 6929 ribulose-1,5-bisphosphate carboxylase in the cyanobacterium Anabaena Gene ry 7120, 5961 Interspecific DNA transformation in Drosophila, 7515 Gene rearrangement Gene S Expression and rearrangement of homologous immunoglobulin VH genes Expression of hepatitis B virus S gene by herpes simplex virus type 1 in two mouse strains, 2167 vectors carrying a- and 3-regulated gene chimeras, 5867 Two-dimensional S1 nuclease heteroduplex mapping: Detection of Gene Se rearrangements in bacterial genomes, 2723 Biochemical evidence that secretor gene, Se, is a structural gene Spontaneous deletions and duplications of sequences in the genome of encoding a specific fucosyltransferase, 4193 cowpox virus, 6817 Gene sfi A 14;18 and an 8;14 chromosome translocation in a cell line derived from Cell-division control in Escherichia coli: Specific induction of the SOS an acute B-cell leukemia, 7166 function SfiA protein is sufficient to block septation, 4490 Gene rec Gene sis Unusual alleles of recB and recC stimulate excision of inverted repeat Expression of the sis gene by endothelial cells in culture and in vivo, 6772 transposons TnlO and TnS, 824 Gene skc Rapid mutational analysis of regulatory loci in Escherichia coli K-12 using Streptokinase: Cloning, expression, and excretion by Escherichia bacteriophage M13, 3801 ccli, 3557 Molecular analysis of the recF gene of Escherichia coli, 4622 Gene spoOB recA-independent recombination of y8 termini and at IS3 producing Nucleotide sequence of the spoOB gene of Bacillus subtilis and regulation inverted repetition in F' plasmids, 4869 of its expression, 7012 Evidence for inclusion of regions of nonhomology in heteroduplex Gene sprE products of bacteriophage X recombination, 7180 Enhanced recombination between Xplac5 and F421ac: Identification of The subtilisin E gene of Bacillus subtilis is transcribed from a a cis- and trans-acting factors, 7500 promoter in vivo, 1184 Biological Sciences Subject Index Proc. NatL Acad. Scd USA 81 (1984) 8081

Gene SPT Gene v-src Ty-mediated gene expression of the L YS2 and HIS4 genes of Overexpression of the c-src protein does not induce transformation of Saccharomyces cerevisiae is controlled by the same SPT genes, 2431 NIH 3T3 cells, 7071 Gene src Gene varl Evidence that the Rous sarcoma virus transforming gene product Expandable varl gene of yeast mitochondrial DNA: In-frame insertions phosphorylates phosphatidylinositol and diacylglycerol, 2117 can explain the strain-specific protein size polymorphisms, 3148 Hematopoietic cell transformation by a murine recombinant retrovirus Gene VH containing the src gene of Rous sarcoma virus, 2374 Expression and rearrangement of homologous immunoglobulin VH genes Rous sarcoma virus variants that carry the cellular src gene instead of the in two mouse strains, 2167 viral src gene cannot transform chicken embryo fibroblasts, 4424 Rearranged immunoglobulin heavy chain variable region (VH) pseudogene src- andfps-containing avian sarcoma viruses transform chicken erythroid that deletes the second complementarity-determining region, 5194 cells, 7122 Gene V Gene structure The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts T-cell growth factor: Complete nucleotide sequence and organization of the 2444 the gene in normal and malignant cells, 1634 V,, locus, Characterization of genomic clones specifying rabbit a- and A-ventricular Gene xyl myosin heavy chains, 3044 Nucleotide sequence surrounding transcription initiation site of xyLABC Primary structure of the gene encoding rat preprosomatostatin, 3337 operon on TOL plasmid of Pseudomonas putida, 1688 A single rat fibronectin gene generates three different mRNAs by General amino acid control alternative splicing of a complex exon, 5140 Evidence for translational regulation of the activator of general amino Different evolutionary behavior of structurally related, repetitive acid control in yeast, 6442 sequences occurring in the same Balbiani ring gene in Chironomus Generation time tentans, 5165 Occurrence of cell division is not exponentially distributed: Differences in Structure of the human renin gene, 5999 the generation times of sister cells can be derived from the theory of Structure, linkage, and sequence of the two genes encoding the 8 and Y survival of populations, 2379 subunits of the nicotinic acetylcholine receptor, 7975 Genetic drift Gene suf Drift and mutation with a finite number of allelic states, 530 Suppressor sufJ: A novel type of tRNA mutant that induces translational Genetic element frameshifting, 6105 Staphylococcal enterotoxin A gene is associated with a variable genetic Gene synthesis element, 5179 High-level expression of a chemically synthesized gene for human Genetic engineering interferon-y using a prokaryotic expression vector, 2290 Construction of live vaccines using genetically engineered poxviruses: Synthesis of a gene for human growth hormone and its expression in Biological activity of vaccinia virus recombinants expressing the Escherichia coli, 5956 hepatitis B virus surface antigen and the herpes simplex virus Gene Tla glycoprotein D, 193 Genomic constitution of an H-2:Tla variant leukemia, 6447 In vivo formation of gene fusions encoding hybrid 8-galactosidase Gene Tlym-1 proteins in one step with a transposable Mu-lac transducing phage, 535 Isolation and characterization of a stage-specific transforming gene, Tlym- High-level production of biologically active human a1-antitrypsin in I, from T-cell lymphomas, 2227 Escherichia coli, 669 Gene tmr Genetic heterogeneity Identification of a cloned cytokinin biosynthetic gene, 4776 Interallelic complementation in an inborn error of metabolism: Genetic T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin heterogeneity in argininosuccinate lyase deficiency, 4480 biosynthesis, 5994 Genetic mapping Gene tis Genetic mapping of the human X chromosome by using restriction Nucleotide sequence of the tms genes of the pTiA6NC octopine Ti fragment length polymorphisms, 2836 plasmid: Two gene products involved in plant tumorigenesis, 1728 Somatic cell genetic analysis of human cell surface antigens: Gene toxR Chromosomal assignments and regulation of expression in rodent- Synthesis of cholera toxin is positively regulated at the transcriptional human hybrid cells, 6437 level by toxR, 3471 Genetic monitoring Gene transfer Failure to demonstrate mutations affecting protein structure or function in Identification of Epstein-Barr nuclear antigen polypeptide in mouse and children with congenital defects or born prematurely, 5499 monkey cells after gene transfer with a cloned 2.9-kilobase-pair Genetic switch subfragment of the genome, 43 A genetic switch in vitro: DNA inversion by Gin protein of phage Transformation of Aspergillus nidulans by using a trpC plasmid, 1470 Mu, 2689 Expression of Epstein-Barr virus (EBV) DNA and cloned DNA Genome organization fragments in human lymphocytes following Sendai virus envelope- Frequent generation of nonrescuable reorganized Moloney murine mediated gene transfer, 5926 sarcoma viral genomes, 294 High-efficiency gene transfer into mammalian cells: Generation of helper- Rearranged sequences of a human Kpn I element, 1012 free recombinant retrovirus with broad mammalian host range, 6349 Genomic sequencing Gene transfer in lymphoid cells: Expression of the Thy-1.2 antigen by Genomic sequencing, 1991 Thy-1.1 BW5147 lymphoma cells transfected with unfractionated Gill cellular DNA, 7176 Functional history of two motor neurons and the morphometry of their Recognition of HLA-A2 and -B7 antigens by cloned cytotoxic T neuromuscular junctions in the gill of Aplysia: Evidence for differential lymphocytes after gene transfer into human and monkey, but not aging, 4232 mouse, cells, 7549 Two endogenous neuropeptides modulate the gill and siphon withdrawal Gene thg reflex in Aplysia by presynaptic facilitation involving cAMP-dependent Structure of the Trg protein: Homologies with and differences from other closure of a serotonin-sensitive potassium chatinel, 7956 sensory transducers of Escherichia coli, 3287 Gin protein Gene tip A genetic switch in vitro: DNA inversion by Gin protein of phage Characterization of the Bacillus subtilis tryptophan promoter region, 6315 Mu, 2689 Gene tipC Glia Transformation of Aspergillus nidulans by using a trpC plasmid, 1470 Two antigenically related neuronal cell adhesion molecules of different Gene unc specificities mediate neuron-neuron and neuron-glia adhesion, 267 A selection for myosin heavy chain mutants in the nematode Peptides from the regenerating central nervous system of goldfish Caenorhabditis elegans, 4470 stimulate glia, 3567 Gene uvr Neuronal influence on glial enzyme expression: Evidence from mutant Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from mouse cerebella, 4414 Escherichia coli DNA requires the uvrA, uvrB, and urvC gene Glia cell products, 3821 Polypeptide components and binding functions of neuron-glia cell Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in adhesion molecules, 7989 vitro, 7397 Gliadin Gene v-erb-B Nucleic acid (cDNA) and amino acid sequences of a-type gliadins from The membrane glycoprotein encoded by the retroviral oncogene v-erb-B wheat (Triticum aestivum), 4712 is structurally related to tyrosine-specific protein kinases, 704 Glial fibrillary acidic protein Gene v-fms Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: Nucleotide sequence of the feline retroviral oncogene v-fms shows Structural conservation of intermediate filaments, 2743 unexpected homology with oncogenes encoding tyrosine-specific Glial filament protein protein kinases, 85 Identification of glial filament protein and vimentin in the same Gene v-myc intermediate filament system in human glioma cells, 2102 Biological activities of v-myc and rearranged c-myc oncogenes in rat Glioblastoma cell fibroblast cells in culture, 5758 P-Endorphin: Characterization of binding sites specific for the human Gene v-sis hormone in human glioblastoma SF126 cells, 2921 Blockade of autocrine stimulation in simian sarcoma virus-transformed Giloma cells reverses down-regulation of platelet-derived growth factor A glioma-derived analog to platelet-derived growth factor: Demonstration receptors, 7466 of receptor competing activity and immunological crossreactivity, 926 8082 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984)

Glioma cell-conditioned medium Contacts between hormone receptor and DNA double helix within a C6 glioma cell-conditioned medium induces neurite outgrowth and glucocorticoid regulatory element of mouse mammary tumor survival of rat chromaffin cells in vitro: Comparison with the effects of virus, 3029 nerve growth factor, 2242 RU 486: A steroid with antiglucocorticosteroid activity that only Gliotoidn disinhibits the human pituitary-adrenal system at a specific time of Immunosuppression in vitro by a metabolite of a human pathogenic day, 3879 fungus, 3835 Glucocorticoid-mediated induction of a,-acid glycoprotein: Evidence for Globin hormone-regulated RNA processing, 4241 Determinants for protein localization: 83-Lactamase signal sequence Contacts between hormone receptor and DNA double helix within a directs globin across microsomal membranes, 456 glucocorticoid regulatory element of mouse mammary tumor virus Continuous suppression of globin gene expression and differentiation of (Correction), 5892 Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) Glucocorticoid-sensitive hippocampal neurons are involved in terminating despite the loss of PMA binding sites by down regulation, 2075 the adrenocortical stress response, 6174 Biochemical and physiological correlates of deer mouse a-chain Glucocorticoid receptor hemoglobin polymorphisms, 5484 Monoclonal antibodies against the rat liver glucocorticoid receptor, 1609 (-Globin Evidence for the multicentric origin of the sickle cell hemoglobin gene in Requirement for alanine in the amino acid control of deprivation-induced Africa, 1771 protein degradation in liver, 4270 C-Globin Regulation of pea seed pyrophosphate-dependent phosphofructokinase: Human embryonic C-globin chains in adult patients with a- Evidence for interconversion of two molecular forms as a glycolytic thalassemias, 6188 regulatory mechanism, 5051 Globin gene Glucosamine Activation of a chicken embryonic globin gene in adult erythroid cells by Single-chain structure of human ceruloplasmin: The complete amino acid 5-azacytidine and sodium butyrate, 3954 sequence of the whole molecule, 390 Stable transfer and expression of exogenous human globin genes in Structure of human hemopexin: O-Glycosyl and N-glycosyl sites and human erythroleukemia (K562) cells, 5315 unusual clustering of tryptophan residues, 2021 a-Globin gene Complete amino acid sequence of human plasma /32-glycoprotein I, 3640 5' sequence is utilized in vivo, 2733 Tunicamycin blocks neuritogenesis and glucosamine labeling of An unusual splice efficiently in cerebral neuron cultures, 5638 3-Globin gene gangliosides developing Specific factor conferring nuclease hypersensitivity at the 5' end of the Glucose chicken adult 3-globin gene, 95 Trifluoperazine inhibits insulin action on glucose metabolism in fat cells Nuclear matrix DNA from chicken erythrocytes contains P-globin gene without affecting inhibition of lipolysis, 327 sequences, 3n4 Changes in local cerebral glucose utilization during rewarding brain Origin of the , -globin gene in Blacks: The contribution of recurrent stimulation, 635 mutation or gene conversion or both, 853. Induction of two genes by glucose starvation in hamster fibroblasts, 988 A precise termination site in the mouse ,mair-globin transcription unit Further clues concerning the vectors essential to regulation of hexose (Correction), 2274 transport, as studied in fibroblast cultures from a metabolic P-Thalassemia in Chinese: Use of in vivo RNA analysis and mutant, 1126 oligonucleotide hybridization in systematic characterization of Aging of proteins: Isolation and identification of a fluorescent molecular defects, 2821 chromophore from the reaction of polypeptides with glucose, 2684 A ,3-globin gene, inactive in the K562 leukemic cell, functions normally in Isolation of glucose-containing high-mannose glycoprotein core a heterologous expression system, 4485 oligosaccharides, 6340 Site-specific carcinogen binding to DNA, 5623 In vivo metabolic effects of hyperglycemia in murine radiation-induced Triplication of a four-gene set during evolution of the goat ,B-globin locus fibrosarcoma: A 31P NMR investigation, 6496 produced three genes now expressed differentially during Glucose deprivation development, 6589 Induction of glucose-regulated proteins during anaerobic exposure and of DNA methylation and regulation of the human ,-globin-like genes in heat-shock proteins after reoxygenation, 4843 mouse erythroleukemia cells containing human chromosome 11, 6618 Glucose-6-phosphate dehydrogenase Identification of a retrovirus-like repetitive element in human DNA, 7510 Cytological mapping of the human glucose-6phosphate dehydrogenase a-Amanitin-insensitive transcription of mouse PmaJ"-globin 5'-flanking gene distal to the fragile-X site suggests a high rate of meiotic and structural gene sequences correlates with mRNA expression, 7782 recombination across this site, 7855 Identification of a recent recombination event within the human P-globin Glucose-regulated protein gene cluster, 7875 Induction of two genes by glucose starvation in hamster fibroblasts, 988 e-Globin gene Glucose transporter Mapping of DNase I-hypersensitive sites in the upstream DNA of human Identification and characterization of the glucose transporter of the embryonic e-globin gene in K562 leukemia cells, 2718 blood-brain barrier by cytochalasin B binding and immunological Accurate initiation of human E-globin RNA synthesis by Escherichia coli reactivity, 7233 RNA polymerase in isolated nuclei of K562 erythroleukemia cells, 4051 Glucoside -Globin gene Formation of bile acid glucosides by a sugar nucleotide-independent Gyp' Hereditary persistence of fetal hemoglobig: Cosmid cloning and glucosyltransferase isolated from human liver microsomes, 7036 identification of a specific mutation 5' to the y gene, 4894 Glucosylated protein Glomerular basement membrane Autoantibodies to glucosylated proteins in the plasma of patients with Characterization of heparan sulfate-proteoglycan of glomerular basement diabetes, 3204 membranes, 762 Glucosyltransferase Isolation of the specific glomerular basement membrane antigen involved Formation of bile acid glucosides by a sugar nucleotide-independent in Goodpasture syndrome, 1544 glucosyltransferase isolated from human liver microsomes, 7036 Goodpasture antigen of the glomerular basement membrane: Localization Glutamate to noncollagenous regions of type IV collagen, 3838 Homonuclear 1H double-resonance difference spectroscopy of the rat Glomerulonephritis brain in vivo, 6330 Isolation of the specific glomerular basement membrane antigen involved Glutamate decarboxylase in Goodpasture syndrome, 1544 Immunohistochemical evidence for the coexistence of histidine Glomerulus decarboxylase-like and glutamate decarboxylase-like Specific olfactory receptor populations projecting to identified glomeruli immunoreactivities in nerve cells of the magnocellular nucleus of the in the rat olfactory bulb, 5250 posterior hypothalamus of rats, 7647 De novo cellular synthesis of sulfated proteoglycans of the developing Glutamate dehydrogenase renal glomerulus in vivo, 7108 Carbonyl oxygen exchange evidence of imine formation in the glutamate Glucagon dehydrogenase reaction and identification of the "occult role" of Leukotrienes stimulate insulin release from the rat pancreas, 2199 NADPH, 2747 Conversion of proglucagon in pancreatic alpha cells: The major Glutamate receptor endproducts are glucagon and a single peptide, the major proglucagon Classical conditioning of the rabbit eyelid response increases glutamate fragment, that contains two glucagon-like sequences, 5007 receptor binding in hippocampal synaptic membranes, 2548 Glucagon receptor Spider venoms inhibit L-glutamate binding to brain synaptic membrane Identification of glucagon receptors in rat brain, 4368 receptors, 5571 Selective association of N-methyl aspartate and quisqualate types of L- Cross-reacting material in Gaucher disease fibroblasts, 6506 glutamate receptor with brain postsynaptic densities, 6876 Glucocorticoid Glutamic acid Na+-H+ exchange activity in renal brush border membrane vesicles in Mechanism of the inhibition of the y-carboxylation of glutamic acid by N- response to metabolic acidosis: The role of glucocorticoids, 630 methylthiotetrazole-containing antibiotics, 2893 Glucocorticoid inhibition of initiation of transcription of the DNA Spider venoms inhibit L-glutamate binding to brain synaptic membrane encoding rRNA (rDNA) in lymphosarcoma P1798 cells, 718 receptors, 5571 Induction of mouse metallothionein-I mRNA by bacterial endotoxin is Glutamic-oxaloacetic transaminase independent of metals and glucocorticoid hormones, 1053 Enzymology of the response of the carpal tunnel syndrome to riboflavin Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate and to combined riboflavin and pyridoxine, 7076 glucocorticoid teratogenicity in vitro, 1140 Glutamie synthetase Isolation and characterization of the rat tyrosine aminotransferase Oxidative inactivation of glutamine synthetase subunits, 2011 gene, 1346 Separation of glutamine synthetase species with different states of adenylylation by chromatography on monoclonal anti-AMP antibody affinity columns, 4677 Biological Sciences Subject Index Proc. NatL. Acad Sci USA 81 (1984) 8083

Glutaminyl-tRNA synthetase 32-Glycoprotein Transfer RNA mischarging mediated by a mutant Escherichia coli Complete amino acid sequence of human plasma 32-glycoprotein I, 3640 glutaminyl-tRNA synthetase, 5076 Glycoprotein E3 L-y-Glutamyl-L-cysteinylglycyl ethyl ester Homology of adenoviral E3 glycoprotein with HLA-DR heavy Radioprotection by glutathione ester: Transport of glutathione ester into chain, 6039 human lymphoid cells and fibroblasts, 4732 Glycoproteln gp7O Glutaraldehyde Appearance of cytotoxic antibody to viral gp7O on feline lymphoma cells Antibodies against -y-aminobutyric acid; Specificity studies and (FL-74) in cats during ex vivo immunoadsorption therapy: Quantitation, immunocytochemical results, 3888 characterization, and association with remission of disease and Glutathione ester disappearance of viremia, 3516 Radioprotection by glutathione ester: Transport of glutathione ester into Glycoprten HCMVgp64 human lymphoid cells and fibroblasts, 4732 Cloning and physical mapping of a gene fragment coding for a 64- Glutathione reductase kilodalton major late antigen of human cytomegalovirus, 4965 Enzymology of the response of the carpal tunnel syndrome to riboflavin Glycoprotein hormone and to combined riboflavin and pyridoxine, 7076 Assignment of the genes for the a and 3 subunits of thyrotropin to Glutathione transferase different mouse chromosomes, 517 Regulation of glutathione transferase and DT-diaphorase mRNAs in Synthesis and glycosylation of the common a subunit of human persistent hepatocyte nodules during chemical glycoprotein hormones in mouse cells, 6701 hepatocarcinogenesis, 5091 Glycosaminoglycan Gly-Pro-Arg-Pro Interactions between human tumor cells and fibroblasts stimulate Fibrinopeptide A binds Gly-Pro-Arg-Pro, 4339 hyaluronate synthesis, 6767 Glycan Glycosylation Cross-reactions of polysaccharides of fungi, molds, and yeasts in anti- Glycosylated ovine prolactin, 385 pneumococcal and other antisera, 5247 Accelerated age-related browning of human collagen in diabetes Glycerol phosphate dehydrogenase mellitus, 583 Neuronal influence on glial enzyme expression: Evidence from mutant Monensin prevents terminal glycosylation of the N- and 0-linked mouse cerebella, 4414 oligosaccharides of the HLA-DR-associated invariant chain and inhibits 2-Glycerophosphate it dissociation from the a-P chain complex, 1287 In vivo effects of microinjected alkaline phosphatase and its low Characterization of a herpes simplex virus type 1 mutant resistant to molecular weight substrates on the first meiotic cell division in benzhydrazone, a selective inhibitor of herpesvirus glycosylation, 2440 Xenopus laevis oocytes, 5150 Molecular weight and structural nonequivalence of the mature a subunits of Torpedo californica acetylcholine receptor, 2631 Glycine Biosynthesis of carbonic anhydrase in Chlamydomonas reinhardtii during Plasmid-linked nif and "nod" genes in fast-growing rhizobia that nodulate adaptation to low CO2, 6049 Glycine max, Psophocarpus tetragonolobus, and Vigna Structural analysis of human adult and fetal alkaline phosphatases by unguiculata, 3093 cyanogen bromide peptide mapping, 6120 Glycine-directed peptide amidation: Presence in rat brain of two enzymes Photoaffinity labeling and characterization of the cloned purine-cytosine that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 transport system in Saccharomyces cerevisiae, 6276 (thyrotropin-releasing hormone), 3228 Amino acid sequence and post-translational modification of human Portage of various compounds into bacteria by attachment to glycine interleukin 2, 6486 residues in peptides, 4573 Synthesis and glycosylation of the common a subunit of human Cloned avirulence gene of Pseudomonas syringae pv. glycinea glycoprotein hormones in mouse cells, 6701 determines race-specific incompatibility on Glycine max (L.) Differentiation of human erythroid cells is associated with increased 0- Merr., 6024 glycosylation of the major sialoglycoprotein, glycophorin A, 6752 Vaccinia virus 19-kilodalton protein: Relationship to several mammalian Mechanisms of glycosylation and sulfation in the Golgi apparatus: proteins, including two growth factors, 7363 Evidence for nucleotide sugar/nucleoside monophosphate and Glycine N-methyltransferase nucleotide sulfate/nucleoside monophosphate antiports in the Golgi Glycine N-methyltransferase is a folate binding protein of rat liver apparatus membrane, 7051 cytosol, 3631 Glyoxysome Glycine receptor Maturation of catalase precursor proceeds to a different extent in Monoclonal antibodies and peptide mapping reveal structural similarities glyoxysomes and leaf peroxisomes of pumpkin cotyledons, 4809 between the subunits of the glycine receptor of rat spinal cord, 7224 Goat Glycoenzyme Triplication of a four-gene set during evolution of the goat P-globin locus Partial deglycosylation of chloroplast coupling factor 1 (CF1) prevents the produced three genes now expressed differentially during reconstitution of photophosphorylation, 3733 development, 6589 Glycogenolysis Goblet cell Time-dependent conversion of a,- to ,3-adrenoceptor-mediated Monoclonal antibodies as probes for unique antigens in secretory cells of glycogenolysis in isolated rat liver cells: Role of membrane mixed exocrine organs, 4419 phospholipase A2, 6178 Goblin Goblin (ankyrin) in striated muscle: Identification of the potential Transitions between oscillatory modes in a glycolytic model system, 4394 membrane receptor for erythroid spectrin in muscle cells, 3292 Regulation of pea seed pyrophosphate-dependent phosphofructokinase: Goldfish Evidence for interconversion of two molecular forms as a glycolytic The goldfish nervus terminalis: A luteinizing hormone-releasing hormone regulatory mechanism, 5051 and molluscan cardioexcitatory peptide immunoreactive olfactoretinal Glycophorin pathway, 940 Differentiation of human erythroid cells is associated with increased 0- Peptides from the regenerating central nervous system of goldfish glycosylation of the major sialoglycoprotein, glycophorin A, 6752 stimulate glia, 3567 Glycoprotein Go4gI apparatus Asymmetric acetylcholinesterase is assembled in the Golgi apparatus, 479 Morphologic characterization of the pathway of transferrin endocytosis Ca +-ATPase of the sarcoplasmic reticulum shares a common domain and recycling in human KB cells, 175 with a membrane glycoprotein associated with the cytoskeleton of Asymmetric acetylcholinesterase is assembled in the Golgi apparatus, 479 microvilli, 1130 Isoelectric focusing of plant cell membranes, 4804 Assembly in vitro of a spanning membrane protein of the endoplasmic Accumulation of coated vesicles bearing mannose 6-phosphate receptors reticulum: The El glycoprotein of coronavirus mouse hepatitis virus for lysosomal enzymes in the Golgi region of I-cell fibroblasts, 5135 A59, 1421 (Pro)insulin associates with Golgi membranes of pancreatic B cells, 6743 Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an Mechanisms of glycosylation and sulfation in the Golgi apparatus: integral glycoprotein of the endoplasmic reticulum, 1674 Evidence for nucleotide sugar/nucleoside monophosphate and A carbohydrate side chain on hemagglutinins of Hong Kong influenza nucleotide sulfate/nucleoside monophosphate antiports in the Golgi viruses inhibits recognition by a monoclonal antibody, 1779 apparatus membrane, 7051 Membrane proteins unique to vertebrate olfactory cilia: Candidates for Gonadotropin sensory receptor molecules, 1859 Segregation patterns of polymorphic restriction sites of the gene encoding Schwann cell expression of a major myelin glycoprotein in the absence of the a subunit of human chorionic gonadotropin in trophoblastic myelin assembly, 1864 disease, 2504 The presence of cysteine in the cytoplasmic domain of the vesicular Spatial relationships of the human chorionic gonadotropin (hCG) subunits stomatitis virus glycoprotein is required for palmitate addition, 2050 in the assembly of the hCG-receptor complex in the luteinized rat An evolutionary tree relating eight alphaviruses, based on amino-terminal ovary, 4667 sequences of their glycoproteins, 4702 Sulfation of with a cell-free system, 5320 Isolation of glucose-containing high-mannose glycoprotein core lutropin oligosaccharides oligosaccharides, 6340 Gonadotropin-releasing hormone Protection from rabies by a vaccinia virus recombinant containing the Identification of the second gonadotropin-releasing hormone in chicken rabies virus glycoprotein gene, 7194 hypothalamus: Evidence that gonadotropin secretion is probably Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal controlled by two distinct gonadotropin-releasing hormones in avian signal sequence, 7338 species, 3874 Related cell-surface antigens expressed with positional specificity in Goodpasture syndrome Drosophila imaginal discs, 7485 Isolation of the specific glomerular basement membrane antigen involved Serological cross-reactivity between envelope gene products of type I and in Goodpasture syndrome, 1544 type II human T-cell leukemia virus, 7579 Goodpasture antigen of the glomerular basement membrane: Localization The intracellular pathway and assembly of newly formed variable surface to noncollagenous regions of type IV collagen, 3838 glycoprotein of Trypanosoma brucei, 7703 8084 Biological Sciences Subject Index Proc. Natl. Acad. Sci USA 81 (1984)

Graded response Introductory analysis of the GTP-cap phase-change kinetics at the end of Neurons with graded response have collective computational properties a microtubule, 6728 like those of two-state neurons, 3088 GTP-binding protein Granule Squid rhodopsin and GTP-binding protein crossreact with vertebrate Liposomes as targets for granule cytolysin from cytotoxic large granular photoreceptor enzymes, 5111 lymphocyte tumors, 5551 GTPase Granulocyte Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 Divergence in cholesterol biosynthetic rates and 3-hydroxy-3- molecules, 5704 methylglutaryl-CoA reductase activity as a consequence of granulocyte Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes versus monocyte-macrophage differentiation in HL-60 cells, 894 from GH4C, rat pituitary tumor cells, 6183 Stimulation of human granulocyte function by monoclonal antibody Guanldnoethylmercaptosucdnlc aidd WEM-G1, 1818 Enlephalin convertase localization by Binding of the differentiation-inducer, granulocyte-colony-stimulating (Hlguanidinoethylmercaptosuccinic acid autoradiography: Selective factor, to responsive but not unresponsive leukemic cell lines, 3765 association with enkephalin-containing neurons, 6543 Colony-stimulating factor (CSF) controls proliferation of CSF-dependent Guanine nucleotide cells by acting during the G, phase of the cell cycle, 7451 Recognition of the muscarinic receptor by its endogenous Granuloma neurotransmitter: Binding of [3H]acetylcholine and its modulation by Schistosoma mansoni egg granuloma size reduction in challenged transition metal ions and guanine nucleotides, 3650 baboons after vaccination with irradiated cryopreserved Pertussis toxin differentiates between two mechanisms of attenuation of schistosomula, 3552 cyclic AMP accumulation by muscarinic cholinergic receptors, 5680 Ground squirrel Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 Rapid recovery of body mass after surgical removal of adipose tissue in protein produced in Escherichia coli, 6953 ground squirrels, 2270 Guanine nucleotide binding protein Ground squirrel hepatitis virus A product of yeast RAS2 gene is a guanine nucleotide binding The cloned genome of ground squirrel hepatitis virus is infectious in the protein, 6924 animal, 5849 Guanine ribonucleoside Group selection Intracellular lymphocyte activation and carrier-mediated transport of C8- Group selection for a polygenic behavioral trait: Estimating the degree of substituted guanine ribonucleosides, 862 population subdivision, 6073 Guanosine Growth-assodated triggering factor Regioselective arylation of ribose in adenosine and guanosine with the Substances originating from the optic nerve of neonatal rabbit induce antitumor drug N2-methyl-9-hydroxyellipticinium acetate, 1297 regeneration-associated response in the injured optic nerve of adult Guanylate cyclase rabbit, 7965 Atrial natriuretic factor elicits an endothelium-independent relaxation and Growth control activates particulate guanylate cyclase in vascular smooth muscle, 7661 Cell growth and net Na' flux are inhibited by a protein produced by Guatemala kidney epithelial cells in culture, 793 Guatemalan forest synthesis after Pleistocene aridity, 4856 Growth control in cultured 3T3 fibroblasts: Neutralization and Guinea pig identification of a growth-inhibitory factor by a monoclonal Guinea pig preproinsulin gene: An evolutionary compromise?, 5046 antibody, 2107 Gut A specific mutation abolishing Na+/H' antiport activity in hamster Cloned cDNA to cholecystokinin mRNA predicts an identical fibroblasts precludes growth at neutral and acidic pH, 4833 preprocholecystokinin in pig brain and gut, 4307 Growth factor Gut hormone Distinct mechanisms may account for the growth-promoting activity of Isolation of a large cholecystokinin precursor from canine brain, 6565 interleukin 3 on cells of lymphoid and myeloid origin, 1208 Mechanism of T-cell lymphomagenesis: Transformation of growth-factor- Gypsy transposon dependent T-lymphoblastoma cells to growth-factor-independent T- Long terminal repeat nucleotide sequence and specific insertion of the lymphoma cells, 1742 gypsy transposon, 4462 Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U- 937 monocytes, 2762 H-2 antigen Brain- and liver cell-derived factors are required for growth of human Detection of a secreted form of the murine H-2 class I antigen with an endothelial cells in serum-free culture, 6413 antibody against its predicted carboxyl terminus, 1216 Human interleukin 2 can promote the growth factor and differentiation of Genomic constitution of an H-2:Tla variant leukemia, 6447 single hapten-specific B cells in the presence of specific antigen, 7917 Role of a disulfide bridge in the immune function of major Growth hormone histocompatibility class I antigen as studied by in vitro Tissue concentrations of somatomedin C: Further evidence for multiple mutagenesis, 7544 sites of synthesis and paracrine or autocrine mechanisms of action, 935 Habitat selection Growth hormone-releasing factor regulates growth hormone mRNA in Neophobia in the foraging-site selection of a neotropical migrant bird: An primary cultures of rat pituitary cells, 1553 experimental study, 3778 Growth hormone promotes the differentiation of myoblasts and Hair cell preadipocytes generated by azacytidine treatment of 10TV2 cells, 3429 Mechanoelectrical transducer has discrete conductances in the chick Nucleotide sequence of a growth-related mRNA encoding a member of vestibular hair cell, 1888 the prolactin-growth hormone family, 4255 Hairpin Role of mRNA translational efficiency in bovine growth hormone Demonstration of the production of frameshift and base-substitution expression in Escherichia coli, 5403 mutations by quasipalindromic DNA sequences, 5528 Placental lactogen administration reverses the effect of low-protein diet Hairy cell leukemia on maternal and fetal serum somatomedin levels in the pregnant Repetitive structure in the long-terminal-repeat element of a type II rat, 5853 human T-cell leukemia virus, 4617 Synthesis of a gene for human growth hormone and its expression in Halobacterium Escherichia col, 5956 Bacterio-opsin mRNA in wild-type and bacterio-opsin-deficient Growth hormone gene Halobacterium halobium strains, 125 Requirement for the 3' flanking region of the bovine growth hormone An immune strain of Halobacterium halobium carries the invertible L gene for accurate polyadenylylation, 3944 segment of phage 4cH as a plasmid, 1017 Growth hormone-releasing factor Reconstitution of purified halorhodopsin, 5408 Growth hormone-releasing factor regulates growth hormone mRNA in cultures of rat pituitary cells, 1553 Haloperidol primary a opiates and certain antipsychotic drugs mutually inhibit (+)-[3HJSKF Isolation, primary structure, and synthesis of human hypothalamic 10,047 and [ H]haloperidol binding in guinea pig brain membranes, 5618 somatocrinin: Growth hormone-releasing factor, 4302 Halophyte Growth medium NMR study of chloride ion interactions with thylakoid membranes, 3713 Chemically defined media for cultivation of Naegleria gruberi, 2406 Halorhodopsin Growth rate Reconstitution of 5408 Snail shape and growth rates: Evidence for plastic shell allometry in purified halorhodopsin, Littorina littorea, 811 Halothane Essential site for growth rate-dependent regulation within the Escherichia Halothane shortens acetylcholine receptor channel kinetics without coli gnd structural gene, 7669 affecting conductance, 2929 Growth regulation Hamilton rule Hepatocyte proliferation in vitro: Its dependence on the use of serum-free On the evolution of altruism by kin selection, 1754 hormonally defined medium and substrata of extracellular matrix, 1411 Hapten Nucleotide sequence of a growth-related mRNA encoding a member of Human interleukin 2 can promote the growth factor and differentiation of the prolactin-growth hormone family, 4255 single hapten-specific B cells in the presence of specific antigen, 7917 GTP Hapten-gelatin fractionation Interference of GTP hydrolysis in the mechanism of microtubule Single-cell studies on hapten-specific B cells: Response to T-cell- assembly: An experimental study, 771 dependent antigens, 2479 Phase changes at the end of a microtubule with a GTP cap, 5772 HawafI Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes Inheritance of a secondary sexual character in Drosophila silvestris, 6904 from GH4C1 rat pituitary tumor cells, 6183 Chromosomal mapping of a middle-repetitive DNA sequence in a cluster Stimulatory GTP regulatory unit N. and the catalytic unit of adenylate of five species of Hawaiian Drosophila, 7146 cyclase are tightly associated: Mechanistic consequences, 6579 Biological Sciences Subject Index Proc. NatL. Acad. Sci USA 81 (1984) 8085

Heart Distribution of reversing factor in reticulocyte lysates during active Enhanced oxygen unloading by an interdimerically crosslinked protein synthesis and on inhibition by heme deprivation or double- hemoglobin in an isolated perfused rabbit heart, 2941 stranded RNA, 6998 Inhibition of Na+/Ca2' exchange in membrane vesicle and papillary Heme biosynthesis muscle preparations from guinea pig heart by analogs of amiloride, 3238 Isolation and identification of a cDNA clone coding for rat Dihydropyridine derivatives prolong the open state of Ca channels in uroporphyrinogen decarboxylase, 3346 cultured cardiac cells, 4824 Heme protein Purification of the muscarinic acetylcholine receptor from porcine Comparison of the magnetic properties of deoxy- and photodissociated atria, 4993 myoglobin, 2359 Identification and partial purification of the cardiac sodium-calcium Heme synthesis exchange protein, 6569 Molecular cloning of a cDNA sequence complementary to Amino acid sequence of bovine heart coupling factor 6, 6603 porphobilinogen deaminase mRNA from rat, 5036 Purification of the muscarinic acetylcholine receptor from porcine atria Hemoglobin (Correction), 7258 Long-term cultivation and differentiation of human erythroleukemia cells Heat shock in a protein-free chemically defined medium, 453 Major heat shock gene of Drosophila and the Escherichia coli heat- A quantitative model for the cooperative mechanism of human inducible dnaK gene are homologous, 848 hemoglobin, 1093 groEL and dnaK genes of Escherichia coli are induced by UV irradiation Evidence for rotational contribution to protein-facilitated proton and nalidixic acid in an htpR+-dependent fashion, 1499 transport, 1710 Dictyostelium transposable element DIRS-1 has 350-base-pair inverted Enhanced oxygen unloading by an interdimerically crosslinked terminal repeats that contain a heat shock promoter, 2660 hemoglobin in an isolated perfused rabbit heart, 2941 Induction of y-interferon activity by elevated temperatures in human B- Iron-carbon bond lengths in carbonmonoxy and cyanomet complexes of lymphoblastoid cell lines, 4033 the monomeric hemoglobin III from Chironomus thummi thummi: A Heat shock gene critical comparison between resonance Raman and x-ray diffraction Inducible transcription and puffing in Drosophila melanogaster studies, 5106 transformed with hsp7O-phage X hybrid heat shock genes, 5509 Magnetic susceptibility of oxy- and carbonmonoxyhemoglobins, 5417 Drosophila DNA topoisomerase I is associated with transcriptionally Triplication of a four-gene set during evolution of the goat ,B-globin locus active regions of the genome, 6958 produced three genes now expressed differentially during Heat shock protein development, 6589 Proteins related to the mouse L-cell major heat shock protein are Order of free energy couplings between ligand binding and protein synthesized in the absence of heat shock gene expression, 2317 subunit association in hemoglobin, 7098 Developmental control of the heat shock response in Xenopus, 3138 Hemoglobin Cowtown Teratogens induce a subset of small heat shock proteins in Drosophila Structure of deoxyhemoglobin Cowtown [His HC3(146)f3-+Leu]: Origin of primairy embryonic cell cultures, 4075 the alkaline Bohr effect and electrostatic interactions in Induction of glucose-regulated proteins during anaerobic exposure and of hemoglobin, 4781 heat-shock proteins after reoxygenation, 4843 Hemoglobin degradation Changing patterns of gene expression during sporulation in yeast, 7323 A dual role for the Ca2 -requiring proteinase in the degradation of Inducible expression of a cloned heat shock fusion gene in sea urchin hemoglobin by erythrocyte membrane proteinases, 6714 embryos, 7490 Hemoglobin, embryonic Heat shock response Embryonic -* fetal Hb switch in humans: Studies on erythroid bursts Developmental control of the heat shock response in Xenopus, 3138 generated by embryonic progenitors from yolk sac and liver, 2416 Heat shock regulatory gene htpR influences rates of protein degradation Human embryonic ;-globin chains in adult patients with a- and expression of the Ion gene in Escherichia coli, 6647 thalassemias, 6188 A gene regulating the heat shock response in Escherichia coli also affects Hemoglobin, fetal proteolysis, 6779 -- fetal Hb switch in humans: Studies on bursts Heat shock response regulatory gene (htpR) of Escherichia coli is Embryonic erythroid required for growth at high temperature but is dispensable at low generated by embryonic progenitors from yolk sac and liver, 2416 temperature, 6803 Hemoglobin polymorphism Biochemical and physiological correlates of deer mouse a-chain Heat stability hemoglobin polymorphisms, 5484 Effect of single amino acid replacements on the thermal stability of the switching NH2-terminal domain of phage X repressor, 5685 Hemoglobin Heavy metal Gy+8 Hereditary persistence of fetal hemoglobi: Cosmid cloning and Duplicated heavy metal control sequences of the mouse metallothionein-I identification of a specific mutation 5' to the y gene, 4894 gene, 7392. He obin synthesis Helix-destabilizing protein Differentiation of Friend erythroleukemia cells induced.by Mechanism of the concerted action of recA protein and helix-destabilizing benzodiazepines, 3770 proteins in homologous recombination, 2757 Hemolytic disease of the newborn Helix, triple Production of human monoclonal IgG antibodies against Rhesus (D) Monoclonal antibodies to human type IV collagen: Useful reagents to antigen, 3214 demonstrate the heterotrimeric nature of the molecule, 7343 Hemopexin Helper T cell Structure of human hemopexin: O-Glycosyl and N-glycosyl sites and Role of cell surface immunoglobulin in B-lymphocyte activation, 2466 unusual clustering of tryptophan residues, 2021 Processing of by macrophages: Identification of the Hemophilia B determinant recognized by two T-cell hybridomas, 2489 Regional localization on the human X chromosome and polymorphism of Sendai virus-specific T-cell clones: Induction of cytolytic T cells by an the coagulation factor IX gene (hemophilia B locus), 498 anti-idiotypic antibody directed against a helper T-cell clone, 2850 Hemopoiesis Internal complementarities in the immune system: Regulation of the Disparate differentiation in mouse hemopoietic colonies derived from expression of helper T-cell idiotypes, 4520 paired progenitors, 2520 Hemagglutinin Hemopoietic stem cell Chimeric influenza virus hemagglutinin containing either the NH2 Mouse yolk sac and intraembryonic tissues produce factors able to elicit terminus or the COOH terminus of of vesicular stomatitis differentiation of erythroid burst-forming units and colony-forming virus is defective in transport to the cell surface, 395 units, respectively, 1453 A carbohydrate side chain on hemagglutinins of Hong Kong influenza Hepadnavirus viruses inhibits recognition by a monoclonal antibody, 1779 Transmission of the hepatitis B virus-associated 8 agent to the eastern Shared idiotopes among monoclonal antibodies specific for AIPR/8/34 woodchuck, 2208 (HlN1) and X-31(H3N2) influenza viruses, 1809 The cloned genome of ground squirrel hepatitis virus is infectious in the NH2-terminal hydrophobic region of influenza virus neuraminidase animal, 5849 provides the signal function in translocation, 2327 Heparan sulfate Immunity and protection against influenza virus by synthetic peptide Characterization of heparan sulfate-proteoglycan of glomerular basement corresponding to antigenic sites of hemagglutinin, 2461 membranes, 762 Generation of antibody diversity in the immune response of BALB/c mice Heparan-sulfate lysase to influenza virus hemagglutinin, 3180 Binding of transferrin to the core protein of fibroblast proteoheparan Hematopoietic differentiation sulfate, 5657 Conversion of a stem cell leukemia from a T-lymphoid to a myeloid Heparin phenotype induced by the adenosine deaminase inhibitor 2'- Antithrombin III Toyama: Replacement of arginine-47 by cysteine in deoxycoformycin, 253 hereditary abnormal antithrombin III that lacks heparin-binding Hematopoietic stem cell ability, 289 Long-term cultured B lymphocytes and their precursors reconstitute the Evaluation of critical groups required for the binding of heparin to B-lymphocyte lineage in vivo, 7554 antithrombin, 1030 Heme Heparin-Sepharose affinity chromatography Sequence homology and structural similarity between cytochrome b of Isolation of brain fibroblast growth factor by heparin-Sepharose affinity mitochondrial complex III and the chloroplast b6-complex: Position of chromatography: Identity with pituitary fibroblast growth factor, 6%3 the cytochrome b hemes in the membrane, 674 Hepatitis Protein synthesis in rabbit reticulocytes: A study of the mechanism of The cloned genome of ground squirrel hepatitis virus is infectious in the action of the protein factor RF that reverses protein synthesis inhibition 5849 of heme-deficient reticulocyte lysates, 5379 animal, 8086 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

Hepatitis antigen Expression of hepatitis B virus S gene by herpes simplex virus type 1 Detection of non-A, non-B hepatitis antigen by immunocytochemical vectors carrying a- and (3-regulated gene chimeras, 5867 staining, 3195 Herpes simplex virus latency in isolated human neurons, 6217 Hepatitis B Defective Ca2+ metabolism in Duchenne muscular dystrophy: Effects on Serum a-fetoprotein levels in human disease: Perspective from a highly cellular and viral growth, 7617 specific monoclonal radioimmunoassay, 3869 Herpesvirus Hepatitis B virus Extensive homology exists between Marek disease herpesvirus and its Liver disease associated with duck hepatitis B virus infection of domestic vaccine virus, herpesvirus of turkeys, 3365 ducks, 898 Transformation of owl monkey T cells in vitro with Herpesvirus Transmission of the hepatitis B virus-associated 8 agent to the eastern saimiri, 4563 woodchuck, 2208 Small fragments of herpesvirus DNA with transforming activity contain Hepatitis B viral antigenic structure: Signature analysis by monoclonal insertion sequence-like structures, 4736 radioimmunoassays, 2237 Infection of B lymphocytes by a human herpesvirus, Epstein-Barr virus, Predicted secondary structure similarity in the absence of primary amino is blocked by calmodulin antagonists, 4955 acid sequence homology: Hepatitis B virus open reading frames, 2902 Heterochromatip Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone Characterization of a cloned DNA sequence that is present at marrow culture obtained from a patient recently infected with hepatitis centromeres of all human autosomes and the X chromosome and shows B virus, 3526 polymorphic variation, 4884 Segmental homology and internal repetitiousness identified in putative Heteroduplex mapping nucleic acid polymerase and human hepatitis B surface antigen of Two-dimensional S1 nuclease heteroduplex mapping: Detection of human hepatitis B virlgs, 3781 rearrangements in bacterial genomes, 2723 Specific hepatitis B virus integration in hepatocellular carcinoma DNA Heterogeneous nuclear RNA-ribonucleoprotein complex through a viral 11-base-pair direct repeat, 5350 Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex Expression of hepatitis B virus S gene by herpes simplex virus type 1 (hnRNP): A unique supramolecular assembly, 7471 vectors carrying a- and ,8-regulated gene chimeras, 5867 Heterokaryon Hepatitis B virus surface antigen Toxin-antitoxin selection for isolating somatic cell fusion products Construction of live vaccines using genetically engineered poxviruses: between any cell types, 7822 Biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus Heterosynaptic facilitation glycoprotein D, 193 Branch-specific heterosynaptic facilitation in Aplysia siphon sensory Hepatitis B surface antigen and polymerized albumin binding activity in cells, 2577 sheep serum, 564 Hexamethylenebisacetamide Regulation ofT-cell function by antibodies: Enhancement of the response Inducer-mediated commitment of murine erythroleukemia cells to of human T-cell clones to hepatitis B surface antigen by antigen- terminal cell division: The expression of commitment, 3394 specific monoclonal antibodies, 6846 Hexane Synthesis in animal cells of hepatitis B surface antigen particles carrying In vitro evidence that covalent crosslinking of neurofilaments occurs in y- a receptor for polymerized human serum albumin, 7708 diketone neuropathy, 4979 Hepatocellular carcinoma 1-Hexosaminidase Serum a-fetoprotein levels in human disease: Perspective from a highly cDNA clone for the a-chain of human 83-hexosaminidase: Deficiency of specific monoclonal radioimmunoassay, 3869 a-chain mRNA in Ashkenazi Tay-Sachs fibroblasts, 5394 Specific hepatitis B virus integration in hepatocellular carcinoma DNA Hexose transport through a viral 11-base-pair direct repeat, 5350 Further clues concerning the vectors essential to regulation of hexose Hepatocyte transport, as studied in fibroblast cultures from a metabolic Hepatocyte proliferation in vitro: Its dependence on the use of serum-free mutant, 1126 hormonally defined medium and substrata of extracellular matrix, 1411 Hha I methyltransferase Differential DNase I sensitivity of the albumin and a-fetoprotein genes in In Z-DNA the sequence G-C-G-C is neither methylated by Hha I chromatin from rat tissues and cell lines, 5031 methyltransferase nor cleaved by Hha I restriction endonuclease, 3268 Identity of hepatic membrane transport systems for bile salts, phalloidin, Hibiscus and antamanide by photoaffinity labeling, 5232 Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are by promoting cortical microtubule assembly, 5449 distributed periportally in normal and mevinolin-treated rat livers, 5556 High density lipoprotein Quantitative assay for albumin-producing liver cells after simian virus 40 Localization of the structural gene for human apolipoprotein A-I on the transformation of rat hepatocytes maintained in chemically defined long arm of human chromosome 11, 508 medium, 6378 Characteristics of human lipoproteins isolated by selected-affinity Hepatocyte couplet immunosorption of apolipoprotein A-I, 1356 Isolated rat hepatocyte couplets: A primary secretory unit for High-mannose oligosaccharide electrophysiologic studies of bile secretory function, 6516 Uteroferrin has N-asparagine-linked high-mannose-type oligosaccharides Hepatocyte nodule that contain mannose 6-phosphate, 2985 Regulation of glutathione transferase and DT-diaphorase mRNAs in Isolation of glucose-containing high-mannose glycoprotein core persistent hepatocyte nodules during chemical oligosaccharides, 6340 hepatocarcinogenesis, 5091 Hinge protein Hepatoma cell Kinetics of electron transfer between cardiac cytochromes cl and c, 2026 Loss of reciprocal modulations of growth and liver function of hepatoma Hippocampus cells in culture by contact with cells or cell membranes, 6398 Neurotrophic factor for central neurons, 1248 Phorbol esters moduiate insulin receptor phosphorylation and insulin Kindling alters the calcium/calmodulin-dependent phosphorylation of action in cultured hepatoma cells, 7797 synaptic plasma membrane proteins in rat hippocampus, 1253 Herbicide resistance Behavioral and neurochemical differentiation of specific projections in Herbicide resistance in Chlamydomonas reinhardtii results from a the septal-hippocampal cholinergic pathway of the rat, 1880 mutation in the chloroplast gene for the 32-kilodalton protein of Classical conditioning of the rabbit eyelid response increases glutamate photosystem II, 3617 receptor binding in hippocampal synaptic membranes, 2548 Triazine herbicide resistance in the photosynthetic bacterium Neutotrophic effects of hippocampal extracts on medial septal nucleus in Rhodopseudomonas sphaeroides, 6310 vitro, 2567 Hereditary cutaneous malignant melanoma Modulation of cholecystokinin concentrations in the rat hippocampus by Fibroblasts from patients with hereditary cutaneous malignant melanoma chelation of heavy metals, 5876 are abnormally sensitive to the mutagenic effect of simulated sunlight Hippocampal denervation causes rapid forgetting of olfactory information and 4-nitroquinoline 1-oxide, 1179 in rats, 5885 Hereditary persistence of fetal hemoglobin Glucocorticoid-sensitive hippocampal neurons are involved in terminating Gwp+ Hereditary persistence of fetal hemoglobi: Cosmid cloning and the adrenocortical stress response, 6174 identification of a specific mutation 5' to the -y gene, 4894 Histamine Herpes simplex virus Histamine-containing neurons in the rat hypothalamus, 2572 Construction of live vaccines using genetically engineered poxviruses: Direct demonstration of increased intracellular concentration of free Biological activity of vaccinia virus recombinants expressing the calcium as measured by quin-2 in stimulated rat peritoneal mast hepatitis B virus surface antigen and the herpes simplex virus cell, 3978 glycoprotein D, 193 Leukotriene E4-induced airway hyperresponsiveness of guinea pig Insulin-induced reactivation of an inactive herpes simplex thymidine tracheal smooth muscle to histamine and evidence for three separate kinase gene, 838 sulfidopeptide leukotriene receptors, 4922 Resistance of herpes simplex virus to 9-{[2-hydroxy-1- Immunohistochemical evidence for the coexistence of histidine (hydroxymethyl)ethoxy]methyl}guanine: Physical mapping of drug decarboxylase-like and glutamate decarboxylase-like synergism with the viral DNA polymerase locus, 1556 immunoreactivities in nerve cells of the magnocellular nucleus of the Characterization of a herpes simplex virus type 1 mutant resistant to posterior hypothalamus of rats, 7647 benzhydrazone, a selective inhibitor of herpesvirus glycosylation, 2440 Separation of sequences defining basal expression from those conferring Immunohistochemical evidence for the coexistence of histidine a gene recognition within the regulatory domains of herpes simplex decarboxylase-like and glutamate decarboxylase-like virus 1 a genes, 4065 immunoreactivities in nerve cells of the magnocellular nucleus of the Small fragments of herpesvirus DNA with transforming activity contain posterior hypothalamus of rats, 7647 insertion sequence-like structures, 4736 Histidine permease Yeast gene CDC8 encodes thymidylate kinase and is complemented by ATP-binding sites in the membrane components of the histidine herpes thymidine kinase gene TK, 5821 permease, a periplasmic transport system, 7333 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984) 8087

Histidine tRNA primer Horizontal cell Identification of a retrovirus-like repetitive element in human DNA, 7510 Monoclonal antibodies distinguish subtypes of retinal horizontal Histocompatibility antigen cells, 6255 Class II HLA-DC /3-chain DNA restriction fragments differentiate among Hormonal induction HLA-DR2 individuals in insulin-depen4ent diabetes and multiple Molecular cloning and expression of the mouse ornithine decarboxylase sclerosis, 1774 gene, 540 Functional and inducible expression of a transfected murine class II Hormonal regulation major histocompatibility complex gene, 2045 Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Primary structural evidence that the H-2Dq region encodes at least three Identification of phosphorylated sites and effects on the distinct gene products: Dq, Lq, and RI, 2499 phosphorylation by lipolytic hormones and insulin, 3317 Antigen presentation by supported planar membranes containing affinity- Hormonal stimulus purified I-A', 7564 Quantitative investigation of hepatic genomic response to hormonal and Clusters of HLA class 11,8 restriction fragments describe allelic pathophysiological stimuli by multivariate analysis of two-dimensional series, 7870 mRNA activity profiles, 974 Histocompatibility locus Hormone A human autosomal phosphoglycerate kinase locus maps near the HLA Method for quantitating the molecular content of a subcellular organelle: cluster, 3167 Hormone and neurophysin content of newly formed and aged Histone 1 neurosecretory granules, 180 A placental polypeptide activator of a membranous protein kinase and its Molecular cloning of hormone-responsive genes from the yeast relation to histone 1, 7388 Saccharomyces cerevisiae, 1144 Histone gene Hormonal control of eclosion of flies from the puparium, 1457 Evidence for a human histone gene cluster containing H2B and H2A Seasonal aggression independent of seasonal testosterone in wood pseudogenes, 1936 rats, 5255 Transcription of human histone genes in extracts from synchronized Hormone action HeLa cells, 2713 Molecular cloning of a cDNA for the chicken progesterone receptor B Coordinate replication of members of the multigene family of core and H1 antigen, 6358 human histone genes, 7723 Hormone biosynthesis Histone H1 Conversion of proglucagon in pancreatic alpha cells: The major Cell cycle regulation of human histone H1 mRNA, 434 endproducts are glucagon and a single peptide, the major proglucagon Coordinate replication of members of the multigene family of core and H1 fragment, that contains two glucagon-like sequences, 5007 human histone genes, 7723 Hormone receptor Histone mRNA Contacts between hormone receptor and DNA double helix within a 3' editing of mRNAs: Sequence requirements and involvement of a 60- glucocorticoid regulatory element of mouse mammary tumor nucleotide RNA in maturation of histone mRNA precursors, 1057 virus, 3029 Temporal expression of late histone messenger RNA in the sea urchin Contacts between hormone receptor and DNA double helix within a Lytechinus pictus, 2411 glucocorticoid regulatory element of mouse mammary tumor virus HLA antigen (Correction), 5892 Transcripts of human HLA gene fragments lacking the 5'-terminal region Hormone secretion in transfected mouse cells, 649 Bombesin stimulates insulin secretion by a pancreatic islet cell line, 1822 Monensin prevents terminal glycosylation of the N- and O-linked Relationship between parathyroid hormone secretion and cytosolic oligosaccharides of the HLA-DR-associated invariant chain and inhibits calcium concentration in dispersed bovine parathyroid cells, 3113 it dissociation from the a-f chain complex, 1287 Horseradish peroxidase Identification of a sulfate-bearing molecule associated with HLA class II Specific olfactory receptor populations projecting to identified glomeruli antigens, 1534 in the rat olfactory bulb, 5250 Orientation of loci within the human major histocompatibility complex by Host chromosomal in situ hybridization, 2816 Transfer of nuclei from a parasite to its host, 5420 Transcripts of human HLA gene fragments lacking the 5'-terminal region in transfected mouse cells (Correction), 3243 Host range Six HLA-D region a-chain genes on human chromosome 6: Replication of the broad host range plasmid RSF1010: Requirement for Polymorphisms and associations of DCa-related sequences with DR three plasmid-encoded proteins, 654 types, 3461 Extention of bacteriophage A host range: Selection, cloning, and Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: characterization of a constitutive A receptor gene, 6080 Selectivity among HLA-DRS haplotypes, 3539 High-efficiency gene transfer into mammalian cells: Generation of helper- Molecular organization of the HLA-SB region of the human major free recombinant retrovirus with broad mammalian host range, 6349 histocompatibility complex and evidence for two SB 8-chain "Housekeeping" gene genes, 3934 Complete amino acid sequence for human aldolase B derived from cDNA y-Interferon induces expression of the HLA-D antigens on normal and and genomic clones, 2738 leukemic human myeloid cells, 4080 Methylation of the hypoxanthine phosphoribosyltransferase locus on the Immune interferon activates multiple class II major histocompatibility human X chromosome: Implications for X-chromosome complex genes and the associated invariant chain gene in human inactivation, 2806 endothelial cells and dermal fibroblasts, 4917 Hpa II methylase Isolation of HLA locus-specific DNA probes from the 3'-untranslated Covalent bond formation between a DNA-cytosine methyltransferase and region, 5175 DNA containing 5-azacytosine, 6993 Homology of adenoviral E3 glycoprotein with HLA-DR heavy hsRTVL-H family chain, 6039 Identification of a retrovirus-like repetitive element in human DNA, 7510 Weak HLA and P32-microglobulin expression of neuronal cell lines can be Human beings modulated by interferon, 6476 Fossil vertebrates from Antigua, Lesser Antilles: Evidence for late HLA-linked congenital adrenal hyperplasia results from a defective gene Holocene human-caused extinctions in the West Indies, 4448 encoding a cytochrome P450 specific for steroid 21- Human chorionic gonadotropin hydroxylation, 7505 Segregation patterns of polymorphic restriction sites of the gene encoding Recognition of HLA-A2 and -B7 antigens by cloned cytotoxic T the a subunit of human chorionic gonadotropin in trophoblastic lymphocytes after gene transfer into human and monkey, but not disease, 2504 mouse, cells, 7549 Spatial relationships of the human chorionic gonadotropin (hCG) subunits Clusters of HLA class II13 restriction fragments describe allelic in the assembly of the hCG-receptor complex in the luteinized rat series, 7870 ovary, 4667 Homoeosis Synthesis and glycosylation of the common a subunit of human Homoeosis in Drosophila: The Ultrabithorax larval syndrome, 545 glycoprotein hormones in mouse cells, 6701 Homoeosis in Drosophila: The Ultrabithorax larval syndrome Human cytomegalovirus (Correction), 2273 Cloning and physical mapping of a gene fragment coding for a 64- Structural relationships among genes that control development: Sequence kilodalton major late antigen of human cytomegalovirus, 4965 homology between the Antennapedia, Ultrabithorax, and fushi tarazu Human genetics loci of Drosophila, 4115 for multilocus in 3443 Homology Strategies linkage analysis humans, Segmental homology and internal repetitiousness identified in putative Human growth hormone nucleic acid polymerase and human hepatitis B surface antigen of Synthesis of a gene for human growth hormone and its expression in human hepatitis B virus, 3781 Escherichia coli, 5956 Evolution of multigene families under interchromosomal gene Human growth hormone gene conversion, 3796 Patterns of polymorphism and linkage disequilibrium suggest independent Homonuclear double-resonance difference spectroscopy origins of the human growth hormone gene cluster, 6085 Homonuclear 1H double-resonance difference spectroscopy of the rat Human T-celi leukemia virus brain in vivo, 6330 Nucleotide sequence analysis of the long terminal repeat of human T-cell Homoserine dehydrogenase leukemia virus type II, 1079 Internal homologies in the two aspartokinase-homoserine Monoclonal integration of human T-cell leukemia provirus in all primary dehydrogenases of Escherichia coli K-12, 3019 tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease, 2534 "Hopeful monsters" Human T-cell leukemia virus-associated membrane antigens: Identity of "Hopeful monsters," transposons, and Metazoan radiation, 5482 the major antigens recognized after virus infection, 3856 8088 Biological Sciences Subject Index Proc. Natl. Acad. Sci USA 81 (1984)

Genomes of evolutionarily divergent members of the human T-cell Hydrogenase leukemia virus family (HTLV-I and HTLV-II) are highly conserved, Desulfovibrio vulgaris hydrogenase: A nonheme iron enzyme lacking especially in pX, 4544 nickel that exhibits anomalous EPR and Mossbauer spectra, 3728 Repetitive structure in the long-terminal-repeat element of a type II Hydropathy human T-cell leukemia virus, 4617 Sequence homology and structural similarity between cytochrome b of Bovine leukemia virus: Unique structural features of its long terminal mitochondrial complex III and the chloroplast b6-f complex: Position of repeats and its evolutionary relationship to human T-cell leukemia the cytochrome b hemes in the membrane, 674 virus, 4741 Structural model of human ceruloplasmin based on internal triplication, Envelope proteins of human T-cell leukemia virus: Expression in hydrophilic/hydrophobic character, and secondary structure of Escherichia coli and its application to studies of env gene domains, 4761 functions, 6202 5-Hydroperoxyicosatetraenoic acid Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 cells of patients with adult T-cell leukemia, 6207 synthesis from arachidonic acid, 689 Nucleotide sequence of the 3' region of an infectious human T-cell Hydrophobic moment leukemia virus type II genome, 6657 The hydrophobic moment detects periodicity in Retrovirus-induced expression of interleukin 2 receptors on cells of protein human B-cell lineage, 7441 hydrophobicity, 140 Serological cross-reactivity between envelope gene products of type I Hydrophobicity and moment type II human T-cell leukemia virus, 7579 The hydrophobic detects periodicity in protein Infection of human endothelial cells by human T-lymphotropic virus type hydrophobicity, 140 I, 7588 Amphipathic analysis and possible formation of the ion channel in an Infection of human endothelial cells by human T-cell leukemia virus type acetylcholine receptor, 155 I, 7591 Water structure of a hydrophobic protein at atomic resolution: Pentagon rings of water molecules in crystals of crambin, 6014 Humoral immunity Fusion protein of the paramyxovirus simian virus 5: Nucleotide sequence Long-term cultured B lymphocytes and their precursors reconstitute the of mRNA predicts a highly hydrophobic glycoprotein, 6706 B-lymphocyte lineage in vivo, 7554 N-Hydroxy-2-acetylaminofluorene Hyaluronate Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene Interactions between human tumor cells and fibroblasts stimulate to repetitive sequences of rat liver DNA in vivo, 6943 hyaluronate synthesis, 6767 94[2-Hydroxy-1-(hydrpxymethyl)ethoxylmethyl}guanine Hybrid dysgenesis Resistance of herpes simplex virus to 9-{[2-hydroxy-1- Sequences homologous to P elements occur in Drosophila (hydroxymethyl)ethoxyJmethyl}guanine: Physical mapping of drug paulistorum, 6794 synergism with the viral DNA polymerase locus, 1556 Hybrid protein 3-Hydroxy-3-methylglutaryl-coenzyme A reductase Intracellular targeting and import of an Fl-ATPase a-subunit-p- Divergence in cholesterol biosynthetic rates and 3-hydroxy-3- galactosidase hybrid protein into yeast mitochondria, 3983 methylglutaryl-CoA reductase activity as a consequence of granulocyte A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dml versus monocyte-macrophage differentiation in HL-60 cells, 894 mutant, 5204 Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an Hybridization integral glycoprotein of the endoplasmic reticulum, 1674 Genetic basis of male sterility in hybrids between two closely related Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in species of Drosophila, 4444 familial hypercholesterolemia heterozygotes: Effects on cholesterol Hybridization in situ balance, 2538 Orientation of loci within the human major histocompatibility complex by Hydroxymethylglutaryl-coenzyme A reductase-cQntaining hepatocytes are chromosomal in situ hybridization, 2816 distributed periportally in normal and mevinolin-treated rat livers, 5556 Different central nervous system cell types display distinct and In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A nonrandom arrangements of satellite DNA sequences, 3123 reductase, reductase kinase, and reductase kinase kinase by Simultaneous in situ detection of viral RNA and antigens, 5445 mevalonolactone, 7293 Hybridoma ,-Hydroxyaspartic acid Formation of IgE-binding factors by human T-cell hybridomas, 1514 Cloning and sequencing of liver cDNA coding for bovine protein C, 5653 Messenger RNA for an antigen-specific binding molecule from an antigen- 4-Hydroxydebrisoquine specific T-cell hybrid, 1524 Characterization of a human liver cytochrome P-450 involved in the Isolation of hybridomas expressing a specific heavy chain variable region oxidation of debrisoquine and other drugs by using antibodies raised to gene segment by using a screening technique that detects mRNA the analogous rat enzyme, 7348 sequences in whole cell lysates, 2470 Development of a human T-cell hybridoma secreting separate B-cell 3-Hydroxyfiavone growth differentiation factors, 2475 Proton-transfer spectroscopy of 3-hydroxyflavone in an isolated-site Production of human monoclonal IgG antibodies against Rhesus (D) crystal matrix, 3375 - antigen, 3214 (12S)-Ifydroxyicosatetraenoic acid Immunoglobulin heavy chain toxicity in plasma cells is neutralized by 12S,20-Dihydroxyicosatetraenoic acid: A new icosanoid synthesized by fusion to pre-B cells, 7185 neutrophils from 12S-hydroxyicosatetraenoic acid produced by Toxin-antitoxin selection for isolating somatic cell fusion products thrombin- or collagen-stimulated platelets, 903 between any cell types, 7822 21-Hydroxylase Immunization in vitro and production of monoclonal antibodies specific to Cloning and expression of cDNA encoding a bovine adrenal cytochrome insoluble and weakly immunogenic proteins, 7897 P450 specific for steroid 21-hydroxylation, 1986 Hydration force 21-Hydroxylase deficiency Measurement of the repulsive force between polyelectrolyte molecules in HLA-linked congenital adrenal hyperplasia results from a defective gene ionic solution: Hydration forces between parallel DNA double encoding a cytochrome P450 specific for steroid 21- helices, 2621 hydroxylation, 7505 Hydrocarbon 2-Hydroxyleukotriene Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a Oxidation of leukotrienes at the w end: Demonstration of a receptor for particulate preparation from Pisum sativum, 6613 the 20-hydroxy derivative of leukotriene B4 on human neutrophils and Hydrogen implications for the analysis of leukotriene receptors, 5729 Na+-H+ exchange in gastric glands as measured with a cytoplasmic- 5-Hydroxymethyl-2'-deoxyuridine trapped, fluorescent pH indicator, 7436 Ionizing radiation and tritium transmutation both cause formation of 5- bond hydroxymethyl-2'-deoxyuridine in cellular DNA, 318 Hydro"enStability of "salt bridges" in membrane proteins, 5412 Hydroxymethyluracil DNA glycosylase Hydrogen exchange Hydroxymethyluracil DNA glycosylase in mammalian cells, 4003 Correlation of lac operator DNA imino proton exchange kinetics with its 3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine function, 3665 Psychotomimetic opiate receptors labeled and visualized with (+)-[3HJ3- Hydrogen ion (3-hydroxyphenyl)-N-(1-propyl)piperidine, 4983 See Proton Hydroxyproline Hydrogen ion concentration Abnormal collagen metabolism in cultured skin fibroblasts from patients See also Acid and pH with Duchenne muscular dystrophy, 5130 A specific mutation abolishing Na+/H+ antiport activity in hamster a-Hydroxythymine fibroblasts precludes growth at neutral and acidic pH, 4833 Hydroxymethyluracil DNA glycosylase in mammalian cells, 4003 Hydrogen ion translocation 5-Hydroxytryptamine Subunit b of the membrane moiety (FO) of ATP synthase (FIFO) from Serotonin binds specifically and saturably to an actin-like protein isolated Escherichia coli is indispensable for H+ translocation and binding of from rat brain synaptosomes, 959 the water-soluble F1 moiety, 7279 Hydroxyurea Hydrogen peroxide Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate- Lignin-degrading enzyme from Phanerochaete chrysosporium: effected tumor promotion in mouse skin by nontoxic inhibition of DNA Purification, characterization, and catalytic properties of a unique synthesis, 5858 H 0,-requiring oxygenase, 2280 25-Hydroxyvitamin D3 DNX damage related to increased hydrogen peroxide generation by Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro, 931 hypolipidemic drug-induced liver peroxisomes, 7827 Hyperglycemia Hydrogen uptake Isolation and primary structure of two peptides with cardioacceleratory H2-uptake activity of the MoFe protein component of Azotobacter and hyperglycemic activity from the corpora cardiaca of Periplaneta vinelandii nitrogenase, 376 americana, 5575 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984) 8089

In vivo metabolic effects of hyperglycemia in murine radiation-induced Identifier sequence fibrosarcoma: A 31P NMR investigation, 6496 Brain-specific genes have identifier sequences in their introns, 713 Hyperlipoproteinemla Idlotope Role of apolipoprotein E in the lipolytic conversion of (3-very low density Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 lipoproteins to low density lipoproteins in type III (H1N1) and X-31(H3N2) influenza viruses, 1809 hyperlipoproteinemia, 5566 Idiotype Hyperrecombination Human anti-idiotype antibodies in cancer patients: Is the modulation of Hyperrecombination at a specific DNA sequence in pneumococcal the immune response beneficial for the patient?, 216 transformation, 5184 Anti-hypervariable region antibody induced by a defined peptide: An Hypertension approach for studying the structural correlates of idiotypes, 1784 Synthesis of peptides related to the prosegment of mouse submaxillary Expression and rearrangement of homologous immunoglobulin VH genes gland renin precursor: An approach to renin inhibitors, 48 in two mouse strains, 2167 Human renin gene: Structure and sequence analysis, 5026 Induction of immunity to a human tumor marker by in vivo Intracellular free magnesium in erythrocytes of essential hypertension: administration of anti-idiotypic antibodies in mice, 2864 Relation to blood pressure and serum divalent cations, 6511 Idiotypic determinants of natural IgM antibodies that resemble self Ia Hypervariable region antigens, 3175 Anti-hypervariable region antibody induced by a defined peptide: An Chronic treatment with rabbit anti-mouse 1A-chain antibody alters the approach for studying the structural correlates of idiotypes, 1784 characteristic immunoglobulin heavy-chain restriction of murine Hypomethylation suppressor T-cell factors, 3846 Preferential binding of estrogen-receptor complex to a region containing Idiotype expression the estrogen-dependent hypomethylation site preceding the chicken Internal complementarities in the immune system: Regulation of the vitellogenin II gene, 429 expression of helper T-cell idiotypes, 4520 Hypophysectomy a-L-Iduronidase Regression of myelocytic leukemia in rats after hypophysectomy, 598 Regional assignment of the structural gene for human a-L- Hypoprothrombinemia iduronidase, 1169 Mechanism of the inhibition of the y-carboxylation of glutamic acid by N- Ig methylthiotetrazole-containing antibiotics, 2893 See also Immunoglobulin Hypothalamic hormone IgE Inhibition of growth of pancreatic carcinomas in animal models by Formation of IgE-binding factors by human T-cell hybridomas, 1514 analogs of hypothalamic hormones, 248 IgE-binding factor Hypothalamus Formation of IgE-binding factors by human T-cell hybridomas, 1514 Histamine-containing neurons in the rat hypothalamus, 2572 IgG2a Identification of the second gonadotropin-releasing hormone in chicken Tumors undergoing rejection induced by monoclonal antibodies of the hypothalamus: Evidence that gonadotropin secretion is probably IgG2a isotype contain increased numbers of macrophages activated for controlled by two distinct gonadotropin-releasing hormones in avian a distinctive form of antibody-dependent cytolysis, 3506 species, 3874 1gM Isolation, primary structure, and synthesis of human hypothalamic Somatic diversification of immunoglobulins, 2162 somatocrinin: Growth hormone-releasing factor, 4302 Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM Vasopressin gene is expressed at low levels in the hypothalamus of the autoantibodies, 2494 Brattleboro rat, 5296 Beum Lipoprotein lipase is produced, regulated, and functional in rat Specific binding of leukotriene C4 to ileal segments and subcellular brain, 7604 fractions of ileal smooth muscle cells, 4529 Immunohistochemical evidence for the coexistence of histidine Ileum myenteric plexus decarboxylase-like and glutamate decarboxylase-like Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum immunoreactivities in nerve cells of the magnocellular nucleus of the myenteric plexus, 7253 posterior hypothalamus of rats, 7647 A ligand-specific action of chelated copper on hypothalamic neurons: Imaginal disc Stimulation of the release of luteinizing hormone-releasing hormone Related cell-surface antigens expressed with positional specificity in from median eminence explants, 7656 Drosophila imaginal discs, 7485 Hypoxanthine phosphoribosyltransferase Imaginal disc development Differential methylation of hypoxanthine phosphoribosyltransferase genes Specific protein modifications are altered in a temperature-sensitive on active and inactive human X chromosomes, 1759 Drosophila developmental mutant, 6422 Structure, expression, and mutation of the hypoxanthine Impse phosphoribosyltransferase gene, 2147 In vivo nuclear magnetic resonance chemical shift imaging by selective Polycyclic aromatic hydrocarbon mutagenesis of human epidermal irradiation, 6856 keratinocytes in culture, 7802 Imine Hypoxanthine phosphoribosyltransferase gene Carbonyl oxygen exchange evidence of imine formation in the glutamate Methylation of the hypoxanthine phosphoribosyltransferase locus on the dehydrogenase reaction and identification of the "occult role" of human X chromosome: Implications for X-chromosome NADPH, 2747 inactivation, 2806 Imino proton Hypoxemia Correlation of lac operator DNA imino proton exchange kinetics with its Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at function, 3665 relatively low field strengths (1.9 T), 2517 Iminol Hypoxia The possibility that the spectrum of intermediate two, seen in the course Mechanism of cytoplasmic pH regulation in hypoxic maize root tips and of reaction of flavoenzyme phenol hydroxylases, may be attributable to its role in survival under hypoxia, 3379 iminol isomers of a flavin-derived 6-arylamino-5-oxo(3H,5H)uracil, 332 Induction of glucose-regulated proteins during anaerobic exposure and of Immediate early gene heat-shock proteins after reoxygenation, 4843 Promoter-regulatory region of the major immediate early gene of human Cytoplasmic acidosis as a determinant of flooding intolerance in cytomegalovirus, 659 plants, 6029 Immediate hypersensitivity Prevention of some electrophysiologic and biochemical abnormalities with Adenosine release from stimulated mast cells, 6192 oxygen supplementation in experimental diabetic neuropathy, 6894 Immortalization Hystricomorph Biological activities of v-myc and rearranged c-myc oncogenes in rat Guinea pig preproinsulin gene: An evolutionary compromise?, 5046 fibroblast cells in culture, 5758 Immune cell interaction I-A antigen Thymus-derived lymphocytes and their interactions with macrophages are Disappearance and reappearance of B cells after in vivo treatment with required for the production of osteoclast-activating factor in the monoclonal anti-I-A antibodies, 2855 mouse, 2181 I region Immune function Cell-type-specific cDNA probes and the murine I region: The localization Role of a disulfide bridge in the immune function of major and orientation of Ad, 2194 histocompatibility class I antigen as studied by in vitro Ia antigen mutagenesis, 7544 Identification of a sulfate-bearing molecule associated with HLA class II Immune response antigens, 1534 Human anti-idiotype antibodies in cancer patients: Is the modulation of Cell-type-specific cDNA probes and the murine I region: The localization the immune response beneficial for the patient?, 216 and orientation of Ad, 2194 Generation of antibody diversity in the immune response of BALB/c mice Idiotypic determinants of natural IgM antibodies that resemble self Ia to influenza virus hemagglutinin, 3180 antigens, 3175 Genetic control of major histocompatibility complex-linked immune Molecular organization of the HLA-SB region of the human major responses to synthetic polypeptides in man: Poly(L-phenylalanine, histocompatibility complex and evidence for two SB (3-chain L-glutamic acid)-poly(DL-alanine)--poly(L-lysine) and L-glutamic acid, genes, 3934 L-alanine, L-tyrosine (60:30:10), 3521 Increased expression of Ia antigens on resting B cells: An additional role Regulation of T-cell function by antibodies: Enhancement of the response for B-cell growth factor, 6149 of human T-cell clones to hepatitis B surface antigen by antigen- Ice nucleation specific monoclonal antibodies, 6846 Cloned avirulence gene of Pseudomonas syringae pv. glycinea Immunity determines race-specific incompatibility on Glycine max (L.) Prothymosin a: Isolation and properties of the major immunoreactive Merr., 6024 form of thymosin a, in rat thymus, 1008 8090 Biological Sciences Subject Index Proc. Nati. Acad. Sci. USA 81 (1984)

Differential effects of the mottled yellow and pseudoagouti phenotypes on A 14;18 and an 8;14 chromosome translocation in a cell line derived from immunocompetence in AvY/a mice, 2152 an acute B-cell leukemia, 7166 T-cell-mediated cytotoxicity against autologous malignant melanoma: Immunoglobulin gene rearrangement Analysis with interleukin 2-dependent T-cell cultures, 3511 Illegitimate recombination generates a class switch from C to C,, in an Immunization IgD-secreting plasmacytoma, 4164 i Protective immunization of the squirrel monkey against asexual blood Immunoglobulin heavy chain stages of Plasmodium falciparum by use of parasite protein Allelic inclusion in the pre-B-cell line 18-81, 867 fractions, 229 Expression of immunoglobulin heavy chain at a high level in the absence Immunity and protection against influenza virus by synthetic peptide of a proposed immunoglobulin enhancer element in cis, 2452 corresponding to antigenic sites of hemagglutinin, 2461 Isolation of hybridomas expressing a specific heavy chain variable region Immunization in vitro gene segment by using a screening technique that detects mRNA Immunization in vitro and production of monoclonal antibodies specific to sequences in whole cell lysates, 2470 insoluble and weakly immunogenic proteins, 7897 Chronic treatment with rabbit anti-mouse p-chain antibody alters the Immunoadsorbant characteristic immunoglobulin heavy-chain restriction of murine Separation of glutamine synthetase species with different states of suppressor T-cell factors, 3846 adenylylation by chromatography on monoclonal anti-AMP antibody The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) affinity columns, 4677 translocation involves the immunoglobulin heavy chain locus, 4144 Immunoadsorption therapy Rearranged immunoglobulin heavy chain variable region (VH) pseudogene Appearance of cytotoxic antibody to viral gp7O on feline lymphoma cells that deletes the second complementarity-determining region, 5194 (FL-74) in cats during ex vivo immunoadsorption therapy: Quantitation, Somatic mutation of the T15 heavy chain gives rise to an antibody with characterization, and association with remission of disease and autoantibody specificity, 5841 disappearance of viremia, 3516 Immunoglobulin heavy chain toxicity in plasma cells is neutralized by Immunoassay fusion to pre-B cells, 7185 An immunological method for detecting gene expression in yeast Polymorphisms of a human variable heavy chain gene show linkage with colonies, 7426 constant heavy chain genes, 7840 Immunocompetence Immunoglobulin heavy chain gene Differential effects of the mottled yellow and pseudoagouti phenotypes on Multiple gene deletions within the human immunoglobulin heavy-chain immunocompetence in AvY/a mice, 2152 cluster, 5811 Immunocytochemistry Immunoglobulin light chain Antibodies against y-aminobutyric acid; Specificity studies and Mice completely suppressed for the expression of immunoglobulin K immunocytochemical results, 3888 chain, 211 Immunodeficiency Two regulatory elements for immunoglobulin K light chain gene Thymosin increases production of T-cell growth factor by normal human expression, 7041 peripheral blood lymphocytes, 2882 Immunoglobulin M Immunodeficiency with defective T-cell response to interleukin 1, 4945 IgM in a human neuropathy related to paraproteinemia binds to a Novel B-cell maturation factor from spontaneously autoimmune viable carbohydrate determinant in the myelin-associated glycoprotein and to motheaten mice, 7199 a ganglioside, 1225 Anti-hypervariable region antibody induced by a defined peptide: An Immunoelectron microscopy approach for studying the structural correlates of idiotypes, 1784 An improved procedure for immunoelectron microscopy: Ultrathin plastic Idiotypic determinants of natural IgM antibodies that resemble self Ia embedding of immunolabeled ultrathin frozen sections, 5744 antigens, 3175 Immunoglobulin Antibodies of the secondary response can be expressed without switch See also Ig recombination in normal mouse B cells, 7189 Expression of an immunoglobulin heavy chain gene transfected into Immunoglobulin l chain lymphocytes, 1292 Chronic treatment with rabbit anti-mouse A-chain antibody alters the A genomic gene encoding the bS rabbit immunoglobulin K constant characteristic immunoglobulin heavy-chain restriction of murine region: Implications for latent allotype phenomenon, 1789 suppressor T-cell factors, 3846 K-chain allotypes and isotypes in the rabbit; cDNA sequences of clones encoding b9 suggest an evolutionary pathway and possible role of the Immunoglobulin, surface interdomain disulfide bond in quantitative allotype expression, 1794 Role of cell surface immunoglobulin in B-lymphocyte activation, 2466 Somatic diversification of immunoglobulins, 2162 Immunohistochemistry Expression and rearrangement of homologous immunoglobulin VH genes Compartmental distribution of striatal cell bodies expressing in two mouse strains, 2167 [Metlenkephalin-like immunoreactivity, 7980 Restricted association of V and J-C gene segments for mouse X light Immunolabeling chains, 2484 An improved procedure for immunoelectron microscopy: Ultrathin plastic Generation of antibody activity from immunoglobulin polypeptide chains embedding of immunolabeled ultrathin frozen sections, 5744 produced in Escherichia coli, 3273 Immunological function Diversity at the variable-joining region boundary of X light chains has a Influence of early or late dietary restriction on life span and pronounced effect on immunoglobulin ligand-binding activity, 6139 immunological parameters in MRL/Mp-lpr/lpr mice, 5831 Chimeric human antibody molecules: Mouse antigen-binding domains Immunological repertoire with human constant region domains, 6851 Mice completely suppressed for the expression of immunoglobulin K Restricted association of VJC gene segments for mouse X light chains chain, 211 (Correction), 8019 Immunoprecipitation Immunoglobulin allotype Chemically modified nucleic acids as immunodetectable probes in Induction of immunoglobulin allotypic suppression in the rabbit: A hybridization experiments, 3466 cellular approach, 2859 Immunoradiometric assay Immunoglobulin D Use of monoclonal antibodies as sensitive and specific probes for Illegitimate recombination generates a class switch from C. to C, in an biologically active human y-interferon, 5219 IgD-secreting plasmacytoma, 4164 Immunoregulation Immunoglobulin E Contrasting biological activities of thymopoietin and splenin, two closely Direct demonstration of increased intracellular concentration of free related polypeptide products of thymus and spleen, 2847 calcium as measured by quin-2 in stimulated rat peritoneal mast Immunoselection cell, 3978 Genomic constitution of an H-2:Tla variant leukemia, 6447 Expression of a biologically active fragment of human IgE E chain in Immunosorption Escherichia coli, 5369 Characteristics of human lipoproteins isolated by selected-affinity Immunoglobulin e chain immunosorption of apolipoprotein A-I, 1356 Properties of a human immunoglobulin E-chain fragment synthesized in Immunosuppression Escherichia coli, 2955 Antileukemic and immunosuppressive activity of 2-chloro-2'- Immunoglobulin G deoxyadenosine, 2232 Fc-mediated binding of IgG to vimentin-type intermediate filaments in Human T-lymphocyte subset specificity of the regulatory effects of vascular endothelial cells, 3103 leukotriene B4, 3501 The increase in intracellular free calcium associated with IgGy2b/yl Fc Immunosuppression in vitro by a metabolite of a human pathogenic receptor-ligand interactions: Role in phagocytosis, 5430 fungus, 3835 The increase in intracellular free calcium associated with IgGy2b/yl Fc Modulation of human lymphocyte responses by low density lipoproteins receptor-ligand interactions: Role in phagocytosis (Correction), 7258 (LDL): Enhancement but not immunosuppression is mediated by LDL Immunoglobulin gene receptors, 4539 Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell Immunosurveillance lymphoma, 593 Malignant growth in the normal host after variant selection in vitro with K gene diversity among the clonal progeny of pre-B lymphocytes, 1529 Genomic sequencing, 1991 cytolytic T-cell lines, 2186 The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts Immunotherapy the V1K locus, 2444 Disappearance and reappearance of B cells after in vivo treatment with Structure of the 5' ends of immunoglobulin genes: A novel conserved monoclonal anti-I-A antibodies, 2855 sequence, 2650 Inborn error of metabolism Different joining region J elements of the murine K immunoglobulin light Interallelic complementation in an inborn error of metabolism: Genetic chain locus are used at markedly different frequencies, 4756 heterogeneity in argininosuccinate lyase deficiency, 4480 Translocation and rearrangement of c-myc into immunoglobulin a heavy Incompatibility chain locus in primary cells from acute lymphocytic leukemia, 5514 Plasmid P1 replication: Negative control by repeated DNA Enhancer-dependent expression of human K immunoglobulin genes sequences, 6456 introduced into mouse pre-B lymphocytes by electroporation, 7161 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984) 8091

Indole-3-acetic acid Insertion Indole-3-acetic acid sensitization of phytochrome-controlled growth of Ty-mediated gene expression of the LYS2 and HIS4 genes of coleoptile sections, 3742 Saccharomyces cerevisiae is controlled by the same SPT genes, 2431 Crown gall oncogenesis: Evidence that a T-DNA gene from the Expandable varl gene of yeast mitochondrial DNA: In-frame insertions Agrobacterium Ti plasmid pTiA6 encodes an enzyme that catalyzes can explain the strain-specific protein size polymorphisms, 3148 synthesis of indoleacetic acid, 5071 Insertion element Indomethacin DNA insertion in the first intron of maize Adhi affects message levels: Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor Cloning of progenitor and mutant Adhi alleles, 4125 BW755C, 2890 Insertion element IS5 Indonesia Distribution of DNA insertion element IS5 in natural isolates of Comparison of immunity to malaria in Sudan and Indonesia: Crisis-form Escherichia coli, 4500 versus merozoite-invasion inhibition, 922 Insertion element ISH1 Induction Bacterio-opsin mRNA in wild-type and bacterio-opsin-deficient Induction of two genes by glucose starvation in hamster fibroblasts, 988 Halobacterium halobium strains, 125 Infant, premature Insertion mutation Failure to demonstrate mutations affecting protein structure or function in Construction of mutants of Moloney murine leukemia virus by children with congenital defects or born prematurely, 5499 suppressor-linker insertional mutagenesis: Positions of viable insertion Inflammation mutations, 4149 Specific covalent binding of platelet-derived growth factor to human Insertion sequence plasma a2-macroglobulin, 342 Small fragments of herpesvirus DNA with transforming activity contain Specific covalent binding of platelet-derived growth factor to human insertion sequence-like structures, 4736 plasma a2-macroglobulin (Correction), 2586 Evidence that a major class of mouse endogenous long terminal repeats Influenza virus (LTRs) resulted from recombination between exogenous retroviral Chimeric influenza virus hemagglutinin containing either the NH2 LTRs and similar LTR-like elements (LTR-IS), 6696 terminus or the COOH terminus of G protein of vesicular stomatitis Nucleotide sequence of the insertion sequence found in the T-DNA virus is defective in transport to the cell surface, 395 region of mutant Ti plasmid pTiA66 and distribution of its homologues A carbohydrate side chain on hemagglutinins of Hong Kong influenza in octopine Ti plasmid, 7495 viruses inhibits recognition by a monoclonal antibody, 1779 Insertion sequence IS3 Shared idiotopes among monoclonal antibodies specific for AIPR/8/34 recA-independent recombination of y8 termini and at IS3 producing (HlNl) and X-31(H3N2) influenza viruses, 1809 inverted repetition in F' plasmids, 4869 NH2-terminal hydrophobic region of influenza virus neuraminidase Insertional mlutagenesis provides the signal function in translocation, 2327 Insertion of retrovirus into the first intron of al(I) collagen gene leads to Immunity and protection against influenza virus by synthetic peptide embryonic lethal mutation in mice, 1504 corresponding to antigenic sites of hemagglutinin, 2461 Insulin Generation of antibody diversity in the immune response of BALB/c mice Trifluoperazine inhibits insulin action on glucose metabolism in fat cells to influenza virus hemagglutinin, 3180 without affecting inhibition of lipolysis, 327 Synthesis of the templates for influenza virion RNA replication in Insulin-induced reactivation of an inactive herpes simplex thymidine vitro, 4682 kinase gene, 838 Inhibin-like peptfde Insulin stimulation of phospholipid methylation in isolated rat adipocyte Synthesis and biological activity of human inhibin-like peptide- plasma membranes, 1089 (1-31), 5399 Bombesin stimulates insulin secretion by a pancreatic islet cell line, 1822 Initfation Leukotrienes stimulate insulin release from the rat pancreas, 2199 Template requirements for initiation of phage 429 DNA replication in Insulin and insulin-like growth factor II permit nerve growth factor vitro, 80 binding and the neurite formation response in cultured human Template requirements for the initiation of adenovirus DNA neuroblastoma cells, 2562 replication, 100 Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Mutational analysis of a regulatory region in bacteriophage X that has Identification of phosphorylated sites and effects on the overlapping signals for the initiation of transcription and phosphorylation by lipolytic hormones and insulin, 3317 translation, 555 Insulin activates the appearance of insulin-like growth factor II receptors Glucocorticoid inhibition of initiation of transcription of the DNA on the adipocyte cell surface, 4028 encoding rRNA (rDNA) in lymphosarcoma P1798 cells, 718 Determination of synaptic phenotype: Insulin and cAMP independently Two initiation sites detected in the small si species of reovirus mRNA by initiate development of electrotonic coupling between cultured dipeptide synthesis in vitro, 1084 sympathetic neurons, 6235 Increased intracellular concentration of an initiator protein markedly (Pro)insulin associates with Golgi membranes of pancreatic B cells, 6743 reduces the minimal sequence required for initiation of DNA Structural stability of the 4-zinc human insulin hexamer, 7093 synthesis, 1336 Identification of the af3 monomer of the adipocyte insulin receptor by Mouse primase initiation sites in the origin region of simian virus 40, 2342 insulin binding and autophosphorylation, 7693 Characterization and purification of a phage 4029-encoded DNA Phorbol esters modulate insulin receptor phosphorylation and insulin polymerase required for the initiation of replication, 5325 action in cultured hepatoma cells, 7797 Protein synthesis in rabbit reticulocytes: A study of the mechanism of Insulin gene action of the protein factor RF that reverses protein synthesis inhibition Extrapancreatic insulin gene expression in the fetal rat, 3635 of heme-deficient reticulocyte lysates, 5379 Guinea pig preproinsulin gene: An evolutionary compromise?, 5046 Isolation of an active transcription initiation complex from HeLa cell-free Insulin-like growth factor extract, 5916 Synthetic somatomedin C: Comparison with natural hormone isolated Distribution of reversing factor in reticulocyte lysates during active from human plasma, 740 protein synthesis and on inhibition by heme deprivation or double- Tissue concentrations of somatomedin C: Further evidence for multiple stranded RNA, 6998 sites of synthesis and paracrine or autocrine mechanisms of action, 935 Multiple initiation sites of DNA replication flanking the origin region of Inhibition of the mitogenic effects of plasma by a monoclonal antibody to Xdv genome, 7402 somatomedin C, 2389 Affecting gene expression by altering the length and sequence of the 5' Insulin and insulin-like growth factor II permit nerve growth factor leader, 7698 binding and the neurite formation response in cultured human Initiation factor 2 neuroblastoma cells, 2562 Mechanism of translational control by partial phosphorylation of the a Insulin activates the appearance of insulin-like growth factor II receptors subunit of eukaryotic initiation factor 2, 352 on the adipocyte cell surface, 4028 Sequence of the initiation factor IF2 gene: Unusual protein features and Placental lactogen administration reverses the effect of low-protein diet homologies with elongation factors, 7787 on maternal and fetal serum somatomedin levels in the pregnant Initiation factor 3 rat, 5853 Escherichia coli translational initiation factor IF3: A unique case of Insulin receptor translational regulation, 7061 Antibody against the insulin receptor causes disappearance of insulin Initiation of replication receptors in 3T3-L1 cells: A possible explanation of antibody-induced Purification in a functional form of the terminal protein of Bacillus insulin resistance, 2508 subtilis phage 429, 1639 Insulin receptor is an insulin-dependent tyrosine protein kinase: Inositol phosphate Copurification of insulin-binding activity and protein kinase activity to Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis homogeneity from human placenta, 3327 and phosphoinositide hydrolysis and mobilizes intracellular calcium in Avidin-biotin affinity chromatography: Application to the isolation of cultured arterial muscle cells, 7812 human placental insulin receptor, 7328 Inositol-1-phosphate synthase Analysis of the insulin receptor by anti-receptor antibodies and flow Isolation of the yeast INOI gene: Located on an autonomously cytometry, 7446 replicating plasmid, the gene is fully regulated, 3816 Identification of the caf monomer of the adipocyte insulin receptor by Inositol 1,4,5-trisphosphate insulin binding and autophosphorylation, 7693 myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in Phorbol esters modulate insulin receptor phosphorylation and insulin saponin-permeabilized human platelets, 7431 action in cultured hepatoma cells, 7797 Insect Insulin resistance Isolation and primary structure of two peptides with cardioacceieratory Antibody against the insulin receptor causes disappearance of insulin and hyperglycemic activity from the corpora cardiaca of Periplaneta receptors in 3T3-L1 cells: A possible explanation of antibody-induced americana, 5575 insulin resistance, 2508 8092 Biological Sciences Subject Index Proc. Nati. Acad. Sci. USA 81 (1984)

Integration host factor Thymosin increases production of T-cell growth factor by normal human In vitro regulation of phage A cII gene expression by Escherichia coli peripheral blood lymphocytes, 2882 integration host factor, 6009 T-cell-mediated cytotoxicity against autologous malignant melanoma: Intercalation Analysis with interleukin 2-dependent T-cell cultures, 3511 Nucleic acid-binding molecules with high affinity and base sequence Role of T3 surface molecules in human T-cell activation: T3-dependent specificity: Intercalating agents covalently linked to activation results in an increase in cytoplasmic free calcium, 4169 oligodeoxynucleotides, 3297 Transformation of owl monkey T cells in vitro with Herpesvirus Condensation of nucleic acids by intercalating aromatic cations, 7368 saimiri, 4563 Interferon Chemical reduction of oxidized human lymphocytes inhibits interleukin 2 Pleiotropic activities of human interferons are mediated by multiple production but not induction of interleukin 2 responsiveness, 5209 response pathways, 170 Cyclosporin A inhibits T-cell growth factor gene expression at the level of Regulated expression of a human interferon gene in yeast: Control by mRNA transcription, 5214 phosphate concentration or temperature, 367 Purification and chemical characterization of the receptor for interleukin Injection of mice with antibody to interferon renders peritoneal 2 from activated human T lymphocytes and from a human T-cell macrophages permissive for vesicular stomatitis virus and lymphoma cell line, 6481 encephalomyocarditis virus, 602 Amino acid sequence and post-translational modification of human Transcripts of human HLA gene fragments lacking the 5'-terminal region interleukin 2, 6486 in transfected mouse cells, 649 Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) Interferon y blocks the growth of Toxoplasma gondii in human fibroblasts pathways of human T-cell activation, 6836 by inducing the host cells to degrade tryptophan, 908 Retrovirus-induced expression of interleukin 2 receptors on cells of Biologic activity in a fragment of recombinant human interferon a, 1045 human B-cell lineage, 7441 Selective reduction of c-myc mRNA in Daudi cells by human 1 Antigen presentation by supported planar membranes containing affinity- interferon, 1747 purified I-A', 7564 High-level expression of a chemically synthesized gene for human Leukemia-derived growth factor (non-interleukin-2) produced by murine interferon-y using a prokaryotic expression vector, 2290 lymphoma T-cell lines, 7807 Novel cluster of a-interferon gene sequences in a placental cosmid DNA Human interleukin 2 can promote the growth factor and differentiation of library, 2435 single hapten-specific B cells in the presence of specific antigen, 7917 Transcripts of human HLA gene fragments lacking the 5'-terminal region Interleukin 3 in transfected mouse cells (Correction), 3243 Isolation and characterization of a mouse cDNA clone that expresses Induction of y-interferon activity by elevated temperatures in human B- mast-cell growth-factor activity in monkey cells, 1070 lymphoblastoid cell lines, 4033 Intermediate filament y-Interferon induces expression of the HLA-D antigens on normal and Association of cytokeratin p39 with DNA in intact Novikoff hepatoma leukemic human myeloid cells, 4080 cells, 419 Monoclonal antibodies against murine y interferon, 4515 Lysosomes are associated with microtubules and not with intermediate Recombinant human y-interferon induces human monocyte polykaryon filaments in cultured fibroblasts, 788 formation, 4554 Intermediate filaments in monkey kidney TC7 cells: Focal centers and Immune interferon activates multiple class II major histocompatibility interrelationship with other cytoskeletal systems, 1117 complex genes and the associated invariant chain gene in human Identification of glial filament protein and vimentin in the same endothelial cells and dermal fibroblasts, 4917 intermediate filament system in human glioma cells, 2102 A species of human a interferon that lacks the ability to boost human Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: natural killer activity, 4926 Structural conservation of intermediate filaments, 2743 Constitutive production of human interferons by mouse cells with bovine Fc-mediated binding of IgG to vimentin-type intermediate filaments in papillomavirus as a vector, 5086 vascular endothelial cells, 3103 Receptors for human y interferon: Binding and crosslinking of 1251 Tumor promoters induce a specific morphological signature in the nuclear labeled recombinant human y interferon to receptors on WISH matrix-intermediate filament scaffold of Madin-Darby canine kidney cells, 5160 (MDCK) cell colonies, 4409 Use of monoclonal antibodies as sensitive and specific probes for Intermediate filament cDNAs from BHK-21 cells: Demonstration of biologically active human y-interferon, 5219 distinct genes for desmin and vimentin in all vertebrate classes, 5970 Secretion of foreign proteins from Saccharomyces cerevisiae directed by Characterization and regulation in the expression of a gene coding for the a-factor gene fusions, 5330 intermediate filament protein desmin, 6909 Receptors for human a and a interferon but not for y interferon are Intersite communication specified by human chromosome 21, 5504 On the mechanism of energy transduction in myosin subfragment 1, 2060 Herpes simplex virus latency in isolated human neurons, 6217 Interspersed repeat Human genomic library screened with 17-base oligonucleotide probes -A large interspersed repeat found in mouse DNA contains a long open yields a novel interferon gene, 6451 reading frame that evolves as if it encodes a protein, 2308 Remission of leukemia and loss of feline leukemia virus in cats injected Intervening sequence with Staphylococcus protein A: Association with increased circulating See also Intron interferon and complement-dependent cytotoxic antibody, 6471 Structure of a human gastrin gene, 1067 Weak HLA and P2-microglobulin expression of neuronal cell lines can be Structure, expression, and mutation of the hypoxanthine modulated by interferon, 6476 phosphoribosyltransferase gene, 2147 Transcriptional induction of two genes in human cells by /3 of interferon, 6733 Intervening sequence in the thymidylate synthase gene bacteriophage 7171 T4, 3049 Internal duplication in human a, and ,1i interferons, Intestinal brush border Interferon induces pulmonary cysts in A2G mice, 7937 in the intestinal brush border Interferon gene Conformational changes sodium-glucose Inhibition of protein synthesis stimulates the transcription of human 3- cotransporter labeled with fluorescein isothiocyanate, 2223 in hamster ovary cells, 3964 Intestine interferon genes Chinese Cloning of a cDNA encoding rat intestinal fatty acid binding protein, 313 Site-specific mutagenesis of the human fibroblast interferon gene, 5662 Cell swelling increases a barium-inhibitable potassium conductance in the Interleukin basolateral membrane of Necturus small intestine, 3591 Purification to homogeneity and partial characterization of interleukin 2 Subcellular distribution of DNA-binding and non-DNA-binding 1,25- from a human T-cell leukemia, 871 in chicken 6711 Functional T cells in athymic nude mice, 886 dihydroxyvitamin D receptors intestine, Effect of ultraviolet radiation on production of epidermal cell thymocyte- Intracisternal A particle activating factor/interleukin 1 in vivo and in vitro, 1198 Amounts, synthesis, and some properties of intracisternal A particle- Distinct mechanisms may account for the growth-promoting activity of related RNA in early mouse embryos, 488 interleukin 3 on cells of lymphoid and myeloid origin, 1208 Introgression Thymic T cells are driven to expand upon interaction with self-class II Natural interspecies transfer of mitochondrial DNA in amphibians, 5802 major histocompatibility complex gene products on accessory Intron cells, 1221 See also Interveningi sequence Immunodeficiency with defective T-cell response to interleukin 1, 4945 Chloroplast tRNA"Y gene contains a long intron in the D stem: Interleukin 1 Nucleotide sequences of tobacco chloroplast genes for tRNAGlY (UCC) Macrophage-derived growth factor for osteoblast-like cells and and tRNAArg (UCU), 405 chondrocytes, 4558 Brain-specific genes have identifier sequences in their introns, 713 Nucleotide sequence of human monocyte interleukin 1 precursor Intervening sequence in the thymidylate synthase gene of bacteriophage cDNA, 7907 T4, 3049 Interleukin 2 Structural analysis of the gene encoding human gastrin: The large intron See also T-cell growth factor contains an Alu sequence, 4662 Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell The structure of the human tissue-type plasminogen activator gene: proliferation through an interleukin 2-dependent autocrine Correlation of intron and exon structures to functional and structural pathway, 1509 domains, 5355 T-cell growth factor: Complete nucleotide sequence and organization of Intron splicing: A conserved internal signal in introns of animal pre- the gene in normal and malignant cells, 1634 mRNAs, 7417 Antigenic stimulation regulates the level of expression of interleukin 2 Intron processing receptor on human T cells, 2172 An unusual 5' splice sequence is efficiently utilized in vivo, 2733 Antibodies of predetermined specificity against chemically synthesized Invasiveness peptides of human interleukin 2, 2176 Invasive behavior of mouse sarcoma cells is inhibited by blocking a Control of biologically active interleukin 2 messenger RNA formation in 37,000-dalton plasma membrane glycoprotein with Fab fragments, 3747 induced human lymphocytes, 2601 Inverted repeat Unusual alleles of recB and recC stimulate excision of inverted repeat transposons TnlO and TnS, 824 Biological Sciences Subject Index Proc. NatL Acad. Sci. USA 81 (1984) 8093

Inverted terminal repeat Isocytochrome c Dictyostelium transposable element DIRS-1 has 350-base-pair inverted Differential regulation of the duplicated isocytochrome c genes in terminal repeats that contain a heat shock promoter, 2660 yeast, 4475 Ion channel Isoelectric focusing Amphipathic analysis and possible formation of the ion channel in an Isoelectric focusing of plant cell membranes, 4804 acetylcholine receptor, 155 Isogamy Time-resolved photolabeling by the noncompetitive blocker Search, encounter rates, and the evolution of anisogamy, 6078 chlorpromazine of the acetylcholine receptor in its transiently open and Isomerism closed ion channel conformations, 1897 Dark-adapted bacteriorhodopsin contains 13-cis,15-syn and all-trans,15- Halothane shortens acetylcholine receptor channel kinetics without anti retinal Schiff bases, 1706 affecting conductance, 2929 Isomerization Synaptic stimulation alters protein phosphorylation in vivo in a single of base Aplysia neuron, 3233 Determination retinal Schiff configuration in Spontaneous openings of the acetylcholine receptor channel, 3901 bacteriorhodopsin, 2055 The increase in intracellular free calcium associated with IgGy2b/yl Fc Fluorescence quantum yield of visual pigments: Evidence for receptor-ligand interactions: Role in phagocytosis, 5430 subpicosecond isomerization rates, 4790 Movement of ions through fixed pores in the neural membrane, 5609 Isopentenyltransferase Different channel properties of Torpedo acetylcholine receptor monomers Identification of a cloned cytokinin biosynthetic gene, 4776 and dimers reconstituted in planar membranes, 6222 Isosafrole A "convertible pore" model of neural membrane conductance, 7238 Structures of cysteine-containing peptides in isosafrole-inducible rat The increase in intracellular free calcium associated with IgGy2b/'yl Fc hepatic microsomal cytochrome P-450d: Sequence homology with 3- receptor-ligand interactions: Role in phagocytosis (Correction), 7258 methylcholanthrene-induced cytochrome P-450c, 4298 Partial purification and functional expression of brain mRNAs coding for Isotove neurotransmitter receptors and voltage-operated channels, 7994 Multiple gene deletions within the human immunoglobulin heavy-chain A noncholinergic site-directed monoclonal antibody can impair agonist- cluster, 5811 induced iqn flux in Torpedo californica acetylcholine receptor, 7999 Antibodies of the secondary response can be expressed without switch Ion pair recombination in normal mouse B cells, 7189 Macroscopic models for studies of electrostatic interactions in proteins: Isozyme Limitations and applicability, 4785 On the amino acid sequence of cytochrome P-450 isozyme 4 from rabbit Stability of "salt bridges" in membrane proteins, 5412 liver microsomes, 4260 Ion transport Human alcohol dehydrogenase: Structural differences between the P3 and Electrical activity and cytosolic calcium regulate levels of tetrodotoxin- y subunits suggest parallel duplications in isoenzyme evolution and sensitive sodium channels in cultured rat muscle cells, 262 predominant expression of separate gene descendants in livers of Reconstitution of neurotoxin-modulated ion transport by the voltage- different mammals, 6320 regulated sodium channel isolated from the electroplax of Isozyme family Electrophorus electricus, 1239 Complete amino acid sequence for human aldolase B derived from cDNA Ionic current and genomic clones, 2738 Electrical polarity in embryos of wild carrot precedes cotyledon differentiation, 6064 Joining region Ionic interaction Restricted association of V and J-C gene segments for mouse X light Statistical mechanics of the B Z transition of DNA: Contribution of chains, 2484 diffuse ionic interactions, 5116 Different joining region J elements of the murine K immunoglobulin light Ionic solution chain locus are used at markedly different frequencies, 4756 Diversity at the variable-joining region boundary of X light chains has a Measurement of the repulsive force between polyelectrolyte molecules in pronounced effect on immunoglobulin ligand-binding activity, 6139 ionic solution: Hydration forces between parallel DNA double Restricted association of VJC gene segments for mouse A light chains helices, 2621 (Correction), 8019 Ionlzin radiation Jurkat cell Ionizing radiation and tritium transmutation both cause formation of 5- Role of T3 surface molecules in human T-cell activation: T3-dependent hydroxymethyl-2'-deoxyuridine in cellular DNA, 318 activation results in an increase in cytoplasmic free calcium, 4169 Ionomycin Juvenile rheumatoid arthritis Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised Inherited extracellular magnesium induce proliferation of chicken heart predisposition to iridocyclitis with juvenile rheumatoid arthritis: mesenchymal cells, 6418 Selectivity among HLA-DRS haplotypes, 3539 Ionophore Kaposi sarcoma Conformational analysis of 6-cis- and 6-trans-leukotriene B4-calcium Infection of human endothelial cells by human T-lymphotropic virus type complexes, 3370 I, 7588 Iridocyclitis Kc chain Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: K gene diversity among the clonal progeny of pre-B lymphocytes, 1529 Selectivity among HLA-DR5 haplotypes, 3539 A genomic gene encoding the b5 rabbit immunoglobulin K constant Iron region: Implications for latent allotype phenomenon, 1789 Human transferrin: cDNA characterization and chromosomal K-chain allotypes and isotypes in the rabbit; cDNA sequences of clones localization, 2752 encoding b9 suggest an evolutionary pathway and possible-role of the Occupancy of the iron binding sites of human transferrin, 4326 interdomain disulfide bond in quantitative allotype expression, 1794 Isolation of the Escherichia coli iron superoxide dismutase gene: Different joining region J elements of the murine K immunoglobulin light Evidence that intracellular superoxide concentration does not regulate chain locus are used at markedly different frequencies, 4756 oxygen-dependent synthesis of the manganese superoxide Two regulatory elements for immunoglobulin K light chain gene dismutase, 4970 expression, 7041 Iron-carbon bond Enhancer-dependent expression of human K immunoglobulin genes Iron-carbon bond lengths in carbonmonoxy and cyanomet complexes of introduced into mouse pre-B lymphocytes by electroporation, 7161 the monomeric hemoglobin III from Chironomus thummi thummi: A Keratin critical comparison between resonance Raman and x-ray diffraction Intermediate filaments in monkey kidney TC7 cells: Focal centers and studies, 5106 interrelationship with other cytoskeletal systems, 1117 Iron-sulfur cluster Epithelial mouse mammary cell line exhibiting normal morphogenesis in Spectroscopic studies of ferricyanide oxidation of Azotobacter vinelandii vivo and functional differentiation in vitro, 3756 ferredoxin I, 1931 Differences in keratin synthesis between normal epithelial cells and Iron-sulfur protein squamous cell carcinomas are mediated by vitamin A, 4280 Desulfovibrio vulgaris hydrogenase: A nonheme iron enzyme lacking Cloning of cDNAs specifying vitamin A-responsive human keratins, 4321 nickel that exhibits anomalous EPR and Mossbauer spectra, 3728 The complete cDNA and deduced amino acid sequence of a type II Iron transport mouse epidermal keratin of 60,000 Da: Analysis of sequence Uteroferrin has N-asparagine-linked high-mannose-type oligosaccharides differences between type I and type II keratins, 5709 that contain mannose 6-phosphate, 2985 Keratinocyte Irradiation Polycyclic aromatic hydrocarbon mutagenesis of human epidermal In vivo nuclear magnetic resonance chemical shift imaging by selective keratinocytes in culture, 7802 irradiation, 6856 Keratolinin Islets of Langerhans Keratolinin: The soluble substrate of epidermal transglutaminase from Prevention of rejection of murine islet allografts by pretreatment with human and bovine tissue, 238 anti-dendritic cell antibody, 3864 a-Keto add Characterization of a somatostatin-28 containing the (Tyr-7, Gly-10) Purification and properties of branched-chain a-keto acid dehydrogenase derivative of 5omatostatin-14: A terminal active product of phosphatase, 4335 prosomatostatin II processing in anglerfish pancreatic islets, 7003 Kidney Isoalioxazine Single channel recordings of calcium-activated potassium channels in the Use of riboflavin-binding protein to investigate steric and electronic apical membrane of rabbit cortical collecting tubules, 4237 relationships in flavin analogs and models, 4246 Mouse kidney and submaxillary gland renin genes differ in their 5' L-Isoaspartate putative regulatory sequences, 5489 Mammalian brain and erythrocyte carboxyl methyltransferases are similar Mep-1 gene controlling a kidney metalloendopeptidase is linked to the enzymes that recognize both D-aspartyl and L-isoaspartyl residues in major histocompatibility complex in mice, 5542 structurally altered protein substrates, 7757 Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues, 5946 8094 Biological Sciences Subject Index Proc. NatL Acad Sci. USA 81 (1984) Inhibition by restricted-calorie diet of lymphoproliferative disease and Lamellar body renal damage in MRL/lpr mice, 6144 Endocytosis in alveolar type II cells: Effect of charge and size of De novo cellular synthesis of sulfated proteoglycans of the developing tracers 6054 h a renal glomerulus in vivo, 7108 Uptake ol lectins by pulmonary alveolar type II cells: Subsequent Kidney epithelial cell deposition into lamellar bodies, 6383 Cell growth and net Na' flux are inhibited by a protein produced by Lamellocyte kidney epithelial cells in culture, 793 Selective destruction of a host blood cell type by a parasitoid wasp, 6154 Kidney transport Lamelolysin Na'-H' exchange activity in renal brush border membrane vesicles in Selective destruction of a host blood cell type by a parasitoid wasp, 6154 response to metabolic acidosis: The role of glucocorticoids, 630 Lampbrush loop Kin selection Lampbrush l6op-specific protein of Drosophila hydei, 3404 On the evolution of altruism by kin selection, 1754 Large-fiber sensory neuropathy Kindling Motor deficits in patients with large-fiber senq9ry neuropathy, 979 Kindling alters the calcium/calmodulin-dependent phosphorylation of Laer light-scattering spectroscopy synaptic plasma membrane proteins in rat hippocampus, 1253 Direct observation of 6-crystallin accumulation by laser light-scattering Kinetic linkage spectroscopy in the chicken embryo lens, 785 Soliton-assisted unidirectional circulation in a biochemical cycle, 4386 Latent infection Kinetic measurement A cis-acting element from the Epstein-Barr viral genome that permits Acetylcholine receptor (from Electrophorus electricus): A comparison of stable replication gf recombinant plasmids in latently infected single-channel current recordings and chemical kinetic cells, 3806 measurements, 5281 Lateral gelcuilate nudaus Kinetoplast DNA Effects of monocular deprivation on the lateral geniculate nucleus in a Evidence for the existence of stable curvature of DNA in solution, 4632 pimate, 2255 Kirromycin Lathyrism Cross-linking of tRNA at two different sites of the elongation factor Organization of collagen types I and V in the embryonic chicken cornea: Tu, 3969 Monoclonal antibody studies, 2791 Kitten a-Latrotoxin Labile nature of the visual recovery promoted by reverse occlusion in Free cytoplasnic Ca2+ 4nd neurotransmitter release: Studies on PC12 monocularly deprived kittens, 286 cells and synaptosomes exposed to a-latrotoxin, 620 Knot Leader RNA A simple topological method for describing stereoisomers of DNA Characterization of leader RNA sequences on the virion and mRNAs of catenanes and knots, 3322 mouse hepatitis virus, a Vytoplasmic RNA virus, 3626 Kpn I element Affecting gene expression by altering the length and sequence of the 5' Rearranged sequences of a human Kpn I element, 1012 leader, 7698 Kynurenine Leader sequence Interferon y blocks the growth of Toxoplasma gondii in human fibroblasts Adenovirus tripartite leader sequence enhances translation of mRNAs by inducing the host cells to degrade 908 late after infection, 3655 tryptophan, Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences, 5489 LI family Leaf A large interspersed repeat found in mouse DNA contains a long open Some plant leaves have orientation-dependent EPR and NMR reading frame that evolves as if it encodes a protein, 2308 spectra, 748 L-form Charge accumulation and photochemistry in leaves studied by Streptococcal L-forms isolated from Drosophila paulistorum semispecies thermoluninegcence and delayed light emission, 1107 cause sterility in male progeny, 282 Evidence that phosphorylation and dephosphorylation regulate the L segment distribution of excitation energy between the two photosystems of An immune strain of Halobacterium halobium carries the invertible L photosynthesis iA vivo: Photoacoustic and fluorimetric study of an segment of phage 4H as a plasmid, 1017 intact leaf, 1614 lac carrier protein Lipid peroxidation forms ethylene from 1-aminocyclopropane-1- Functional molecular weight of the lac carrier protein from Escherichia carboxylic acid and may operate in leaf senescence, 1724 coli as studied by radiation inactivation analysis, 1021 Purified reconstituted lac carrier protein from Escherichia coli is fully Mutations in the dopa decarboxylase gene affect learning in functional, 1629 Drosophila, 3577 Intramolecular dislocation of the COOH terminus of the lac carrier Population differences. in complexity of a learned skill are correlated with protein in reconstituted proteoliposomes, 4672 the brain space involved, 6232 lac operator Understanding biological computation: Reliable learning and Possible ideal lac operator: Escherichia coli lac operator-like sequences recognition, 6871 from eukaryotic genomes lack the central G-C pair, 1624 Lecithin:cholesterol Correlation of lac operator DNA imino proton exchange kinetics with its Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino function, 3665 acid segment with amphipathic helical potential, 5021 Regulation of ribosomal RNA promoters with a synthetic lac Lectin operator, 6929 Uptake of lectins by pulmonary alveolar type II cells: Subsequent lac operon deposition into lamellar bodies, 6383 Anti-mRNA: Specific inhibition of translation of single mRNA Leishanwa molecules, 7525 Evidence for the existence of stable curvature of DNA in solution, 4632 lac repressor Differential expression of mRNAs for a- and 0-tubulin during Possible ideal lac operator: Escherichia coli lac operator-like sequences differentiation of the parasitic protozoan Leishmania mexicana, 5782 from eukaryotic genomes lack the central GC pair, 1624 Lemna Lacrimal gland Demonstration of transcriptional regulation of specific genes by Activation of Ca-dependent K channels by carbamoylcholine in rat phytochrome action, 1112 lacrimal glands, 611 Lens .a Direct observation of 8-crystallin accumulation by laser light-scattering Determinants for protein localization: P-Lactamase signal sequence spectroscopy in the chicken embryo lens, 785 directs globin across microsomal membranes, 456 Nondisulfide polymerization of y- and -crystallins in the human P-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl lens, 2878 transfer to specific amino acid acceptors, 1302 Lens transglutaminase selects specific ,3-crystallin sequences as Lactate substrate, 7017 Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at r-Crystallin family of the mouse lens: Structural and evolutionary relatively low field strengths (1.9 T). 2517 relationships, 7762 Lactation Lentivirus Evidence for physiological function of epidermal growth factor: Slow virus visna: Reproduction in vitro of virus from extrachromosomal Pregestational sialoadenectomy of mice decreases milk production and DNA, 7212 increases offspring mortality during lactation period, 6059 Leptoplna Ljkqc acidosis Selective destruction of a host blood cell type by a parasitoid wasp, 6154 "1p NMR study of improvement in oxidative phosphorylation by vitamins Lethal mutation K3 and C in a patient with a defect in electron transport at complex III Insertion of retrovirus into the first intron of al(I) collagen gene leads to in skeletal muscle, 3529 embryonic lethal mutation in mice, 1504 LamB protein Leu-2 antigen Extention of bacteriophage X host range: Selection, cloning, and Isolation of the gene encoding the human T-lymphocyte differentiation characterization of a constitutive X receptor gene, 6080 antigen Leu-2 (T8) by gene transfer and cDNA subtraction, 7688 A chain Leucine operon Restricted association of V and J-C gene segments for mouse A light Detecting protein-DNA interactions in vivo: Distribution of RNA _chains, 2484 polymerase on specific bacterial genes, 4275 Diversity at the variable-joining region boundary of A light chains has a Leukemia pronounced effect on immunoglobulin ligand-binding activity, 6139 Conversion of a stem cell leukemia from a T-lymphoid to a myeloid Restricted association of VJC gene segments for mouse X light chains phenotype induced by the adenosine deaminase inhibitor 2'- (Correction), 8019 deoxycoformycin, 253 Biological Scienceg Subject Index Proc. Natl. Acad. ScL USA 81 (1984) 8095

Long-term cultivation and differentiation of human erythroleukemia cells Leukotriene E4 in a protein-free chemically defined medium, 453 Leukotriene E4-induced airway hyperresponsiveuiess of guinea pig Regression of myclocytic leukemia in rats after hypophysectomy, 598 tracheal smooth muscle to histamine and evidence for three separate Purification to homogeneity and partial characterization of interleukin 2 sulfidopeptide leukotriene receptors, 4922 from a human T-cell leukemia, 871 Leukotriefe receptor Molecular cloning of a unique human T-cell leukemia virus (HTLV- Leukotriene E4-induced airway byperresponsiveness of guinea pig I1Mo), 993 tracheal smooth muscle to histamine and evidence for three separate Nucleotide sequence analysis of the long terminal repeat of human T-cell sulfidopeptide leukotriene receptors, 4922 leukemia virus type II, 1079 Oxidation of leukotrienes at the w end: Demonstration of a receptor for Antileukemic and immunosuppressive activity of 2-chloro-2'- the 20-hydroxy derivative of leukotriene B4 on human neutrophils and deoxyadenosine, 2232 implications for the analysis of leukotriene receptors, 5729 Monoclonal integration of human T-cell leukemia provirus in all primary Leumorphin tumors of adult T-cell leukemia suggests causative role of human T-cell Dyfiorphin converting enzyme with unusual specificity from rat leukemia virus in the disease, 2534 brain, 1892 Human T-cell growth factor: Partial amino acid sequence, cDNA cloning, Life span and organization and expression in normal and leukemic cells, 2543 Influence of early or late dietary restriction on life span and Appearancg of cytotoxic antibody to viral gp7O on feline lymphoma cells immunological parameters in MRL/Mp-lpr/lpr mice, 5831 (FL-74) in cats during ex vivo immunoadsorption therapy: Quantitation, Lidand binding characterization, and association with remission of disease and Order of free energy couplings between ligand binding and protein disappearance of viremia, 3516 subunit association in 7098 y-Interferod ioduces expression of the HLA-D antigens on normal and hemoglobin, leukemit human myeloid cells, 4080 Light Avian myel6blastosis virus and E26 virus oncogene products are nuclear Phototropic response of the stage I Phycomyces sporangiophore to a proteins, 4265 pulse of blue light, 7103 Genomes of evolutionarily divergent members of the human T-cell Light emission leukemia virus family (HTLV-I and HTLV-II) are highly conserved, Charge accumulation and photochemistry in leaves studied by especially in pX, 4544 thermoluminescence and delayed light emission, 1107 Isolation of immortal cell lines from the fifst stage of murihe leukemia Characterization and postulated structure of the primary emitter in the virus-induced leukemia, 5464 bacterial luciferase reaction, 2990 Translocation and rearrangement of cJmyc into immunoglobulin a heavy Light energy conversion chain locus in primary cells from acpte lymphocytic leukemia, 5514 Reconstitution of purified halorhodopsin, 5408 An 8-kilobase abl RNA transcript in chronic myelogenous leukemia, 5648 Liht-harvesting Human T-cell leukemia virus (HTLV-I) trahscripts in fresh and cultured Reaction centerpolypepFtideand light-harvesting I genes from Rhodopseudomonas cells of patients with adult T-cell lehtkeinia, 6207 capsulata, 189 Genomic constitution of an H-2:Tla variant leukemia; 6447 Isolation and characterization of a gene for a major light-harvesting Remission of leukemia and loss of feline leukemia virus in cats ihjected polypeptide from Cyanophora paradoxa, 4100 with Staphylococcus protein A: Association with increased oircilatiig Light response interferon and complement-dependent cytbtoxic antibody, 6471 Rod light response augmented by active , 616 Leukemia, acute ptomyelocytic Light scattering A human c-erbA pncbgene homologue is closely proximal to the Sensitivelight scattering probe of enzymatic processes in retinal rod chromosome 17 breakpoint in acute promyeloeytic ledlkerhia, 4495 photoreceptor membranes, 743 Leukemia cell Occurrence of selediutn-containing tRNAs in mouse leukemia cells, 3010 Lignir;-degrading enzyme from Phanerochaete chrysosporium: A P-globin gene, inactive in the K562 leukemic cell, functions normilly in Purification, characterization, and catalytic properties of a unique a heterologous expression system, 448,5 H202-requiring oxygenase, 2280 Selective killink of leukemic cells by merocyanine 540-mediated Lignoceric acid photosensitization, 7584 Lignoceric acid is oxidized in tile peroxisome: Implications for the Leukemia cell line Zellweger cerebro-hepato-renal syndrome and Binding of the differentiation-inducer, granulocyte-colony-stimulating adrenoleukodystrophy, 4203 factor, to responsive but not unresponsive leukemic cell lines, 3765 Linkage analysis Leukemia-derived growth factor Strategies for multilocus linkage analysis in humans, 3443 Leukemia-derived growth factor (non-interieukin-2) produced by murine Linkage disequilibrium lymphoma T-cell lines, 7807 Linkage disequilibrium and evolutionary relationships of DNA variants Leukemia virus (restriction enzyme fragment length polymorphisms) at the serum Chromosome assighments of four mouse edllular homologs of sarcoma albumin locus; 3486 and leukemia virus oncogenes, 525 Patterns of polymorphism and linkage disequilibrium suggest independent Human T-cell leukemia virus-associated membrane antigens: Identity of origins of thi 11umbin growth hormone gene cluster, 6085 the major antigens recognized after virus infection, 3856 Evidence for linkpge between the loci Eoding for the binding protein for Leukemogenesis the fourth component of human complement (C4BP) and for the C3b/ A molecular.approach, to leukemogenesis: Mbuse lymphomas contain an C4b receptor, 7890 activated c-ras oncogene, 202 Linkage map Leukemogohic virus Lengths of chromosomal segments conserved since divergence of man Characterization of ltuk~mogenic virus produced by a new line of Friend and mouse, 814 erythroleukemia viris-transformed cells, 1831 Linking number Leukocyte A simple topological method for describing stereoisomers of DNA Lipoxins: Novel series of biologically active compounds formed from catenanes and knots, 3322 arachidonic acid in human leukocytes, 5335 Regulation of bacterial DNA supercoiling: Plasmid linking numbers vary Leukocyte activation with growth temperature, 4046 Inhibition of tissue damhge by the arachidonate lipoxygenase inhibitor Lipase BW755C, 2890 Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Leukocyte migration inhibition Identification of phosphorylated sites and effects on the Detection of an Epstein-Barr virus-associated membfane antigen in phosphorylation by lipolytic hormones and insulin, 3317 Epstein-Barr virus-transformed nonproducer tells by leukocyte Lipid migration inhibition anti blocking antibody, 4178 Plasma membrane biogenesis in eukaryotic cells: Translocation of newly Leukotriene synthesized lipid, 1385 Leukotriene B4 action on ondothelium mediates augmented neutrophil/ Detection of erythrocyte membrane proteins, sialoglycoproteins, and endothelial adhesion, 2191 lipids in the same polyacrylamide gel using a double-staining Leukotrienes stimulate insulin release from the rat pancreas, 2199 technique, 1733 Conformational analysis of 6-cis- and 6-trans-leukotriene B4-calcium Tumorigenicity of cell lines with altered lipid composition, 7622 complexes, 3370 Lipid A Specific binding of leukotriene C4 to ileal segments and subcellular Interaction between endotoxin and human monocytes: Characteristics of fractions of ileal smooth muscle cells, 4529 the binding of 3H-labeled lipopolysaccharide and 5tCr-labeled lipid A Oxidation of leukotrienes at the w end: Demonstration of a receptor for before and after the induction of endotoxin tolerance, 3491 the 20-hydroxy derivative of leukotriene B4 on human neutrophils and Lipid activation implications for the analysis of leukotriene receptors, 5729 An Escherichia coli mutant deficient in pyruvate oxidase activity due to Leukotrienes in the rat central nervous system, 6212 altered phospholipid activation of the enzyme, 4348 Letkotriene A4 Lipid b9ayer Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 A Ca +-activated channel from Xenopus laevis oocyte membranes synthesis from arachidonic acid, 689 reconstituted into planar bilayers, 5155 Leukotriene B4 Antigen presentation by supported planar membranes containing affinity- Human T-lymphocyte subset specificity of the regulatory effects of purified I-A , 7564 leukotriene B4, 3501 Lipid oxidation Leukotriene B4 mobilizes calcium without the breakdown of Cholesterol epoxide is a direct-acting mutagen, 4198 polyphosphoinositides and the production of phosphatidic acid in rabbit Lpid peroidation neutrophils, 5966 Lipid feroxidation forms ethylene from 1-aminocyclopropane-1- carboxylic acid and may operate in leaf senescence, 1724 8096 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

Modification of low density lipoprotein by endothelial cells involves lipid Brain- and liver cell-derived factors are required for growth of human peroxidation and degradation of low density lipoprotein endothelial cells in serum-free culture, 6413 phospholipids, 3883 Formation of bile acid glucosides by a sugar nucleotide-independent Detection of superoxide generated by endothelial cells, 7269 glucosyltransferase isolated from human liver microsomes, 7036 Lipid phase Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal Alteration of lipid-phase behavior in multiple sclerosis myelin revealed by signal sequence, 7338 wide-angle x-ray diffraction, 1871 Imaging of hepatic low density lipoprotein receptors by radionuclide Lipid vesicle scintiscanning in vivo, 7599 Reconstitution of purified halorhodopsin, 5408 Liver cancer Lipolysis Specific hepatitis B virus integration in hepatocellular carcinoma DNA Trifluoperazine inhibits insulin action on glucose metabolism in fat cells through a viral 11-base-pair direct repeat, 5350 without affecting inhibition of lipolysis, 327 Liver disease Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Liver disease associated with duck hepatitis B virus infection of domestic Identification of phosphorylated sites and effects on the ducks, 898 phosphorylation by lipolytic hormones and insulin, 3317 Lizard Lipomodulin Eutherian-like reproductive specializations in a viviparous reptile, 4860 Phosphorylation at a tyrosine residue of lipomodulin in mitogen- stimulated murine thymocytes, 4717 LongF-termpotentiationl!assica1 conditioning of the rabbit eyelid response increases glutamate Time-dependent conversion of a,- to (3-adrenoceptor-mediated receptor binding in hippocampal synaptic membranes, 2548 glycogenolysis in isolated rat liver cells: Role of membrane Long terminal repeat phospholipase A2, 6178 Nucleotide sequence analysis of the long terminal repeat of human T-cell Llpopolysaccharide leukemia virus type II, 1079 Induction of mouse metallothionein-I mRNA by bacterial endotoxin is Long terminal repeat nucleotide sequence and specific insertion of the independent of metals and glucocorticoid hormones, 1053 gypsy transposon, 4462 Interaction between endotoxin and human monocytes: Characteristics of Repetitive structure in the long-terminal-repeat element of a type II the binding of 'H-labeled lipopolysaccharide and 51Cr-labeled lipid A human T-cell leukemia virus, 4617 before and after the induction of endotoxin tolerance, 3491 Bovine leukemia virus: Unique structural features of its long terminal Activation and fusion induced by la,25-dihydroxyvitamin D3 and their repeats and its evolutionary relationship to human T-cell leukemia relation in alveolar macrophages, 7112 virus, 4741 Lipoprotein Genomic structure and possible retroviral origin of the chicken CR) Nucleotide sequence and the encoded amino acids of human repetitive DNA sequence family, 6667 apolipoprotein A-I mRNA, 66 Evidence that a major class of mouse endogenous long terminal repeats Characteristics of human lipoproteins isolated by selected-affinity (LTRs) resulted from recombination between exogenous retroviral immunosorption of apolipoprotein A-I, 1356 LTRs and similar LTR-like elements (LTR-IS), 6696 Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich Identification of a retrovirus-like repetitive element in human DNA, 7510 lipoproteins in normal and lipoprotein lipase-deficient humans, 1839 Mouse c-mos oncogene activation is prevented by upstream Complete amino acid sequence of human plasma P2-glycoprotein I, 3640 sequences, 7817 Role of apolipoprotein E in the lipolytic conversion of ,8-very low density Identification of a second transforming region in bovine papillomavirus lipoproteins to low density lipoproteins in type III DNA, 7880 hyperlipoproteinemia, 5566 Longevity Human apolipoprotein C-II: Complete nucleic acid sequence of Effects of food restriction on aging: Separation of food intake and preapolipoprotein C-II, 6354 adiposity, 1835 5a-Cholest-8(14)-en-33-ol-15-one lowers serum cholesterol and induces Influence of early or late dietary restriction on life span and profound changes in the levels of lipoprotein cholesterol and immunological parameters in MRL/Mp-lpr/lpr mice, 5831 apoproteins in monkeys fed a diet of moderate cholesterol Inhibition by restricted-calorie diet of lymphoproliferative disease and content, 6861 renal damage in MRL/lpr mice, 6144 Lipoprotein Upase Carotenoids and retinol: Their possible importance in determining Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich longevity of primate species, 7627 lipoproteins in normal and lipoprotein lipase-deficient humans, 1839 Lophius Human apolipoprotein C-II: Complete nucleic acid sequence of Characterization of a somatostatin-28 containing the (Tyr-7, Gly-10) preapolipoprotein C-II, 6354 derivative of somatostatin-14: A terminal active product of Lipoprotein lipase is produced, regulated, and functional in rat prosomatostatin II processing in anglerfish pancreatic islets, 7003 brain, 7604 Lotka's roots Lipoprotei structure Lotka's roots under rescalings, 3600 Structure of the cholesteryl ester core of human plasma low density Low density lipoprotein lipoproteins: Selective deuteration and neutron small-angle Increased free cholesterol in plasma low and very low density scattering, 4389 lipoproteins in non-insulin-dependent diabetes mellitus: Its role in the Liposome inhibition of cholesteryl ester transfer, 2512 pH-sensitive liposomes: Acid-induced liposome fusion, 1715 Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in Suppression of phagocytic function and phospholipid metabolism in familial hypercholesterolemia heterozygotes: Effects on cholesterol macrophages by phosphatidylinositol liposomes, 2655 balance, 2538 Mechanism of insertion of diphtheria toxin: Peptide entry and pore size Autoantibodies to glucosylated proteins in the plasma of patients with determinations, 3341 diabetes, 3204 Liposomes as targets for granule cytolysin from cytotoxic large granular Modification of low density lipoprotein by endothelial cells involves lipid lymphocyte tumors, 5551 peroxidation and degradation of low density lipoprotein phospholipids, 3883 LipoldnLipoxins: Novel series of biologically active compounds formed from Structure of the cholesteryl ester core of human plasma low density arachidonic acid in human leukocytes, 5335 lipoproteins: Selective deuteration and neutron small-angle Lipoxygenase scattering, 4389 Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 Receptor-mediated endocytosis of low density lipoprotein: Somatic cell synthesis from arachidonic acid, 689 mutants define multiple genes required for expression of surface- Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor receptor activity, 5454 BW755C, 2890 Role of apolipoprotein E in the lipolytic conversion of A-very low density Neurotransmitter receptors mediate cyclic GMP formation by lipoproteins to low density lipoproteins in type III involvement of arachidonic acid and lipoxygenase, 3905 hyperlipoproteinemia, 5566 Lipoxins: Novel series of biologically active compounds formed from Low density lipoprotein receptor arachidonic acid in human leukocytes, 5335 Assignment of the human gene for the low density lipoprotein receptor to Inhibition of human natural killer cell activity by (14R,15S)-14,15- chromosome 19: Synteny of a receptor, a ligand, and a genetic dihydroxy-5Z,8Z,1OE,12E-icosatetraenoic acid, 6914 disease, 2826 Littorina Imaging of hepatic low density lipoprotein receptors by radionuclide Snail shape and growth rates: Evidence for plastic shell allometry in scintiscanning in vivo, 7599 Littorina littorea, 811 Low density lipoproteins Liver Modulation of human lymphocyte responses by low density lipoproteins Quantitative investigation of hepatic genomic response to hormonal and (LDL): Enhancement but not immunosuppression is mediated by LDL pathophysiological stimuli by multivariate analysis of two-dimensional receptors, 4539 mRNA activity profiles, 974 Luciferase Normal liver chromatin contains a firmly bound and larger protein related Characterization and postulated structure of the primary emitter in the to the principal cytosolic target polypeptide of a hepatic bacterial luciferase reaction, 2990 carcinogen, 2092 Lumen formation Requirement for alanine in the amino acid control of deprivation-induced Lumen formation and redistribution of inframembranous proteins during protein degradation in liver, 4270 differentiation of ducts in the rat mammary gland, 5763 Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are Luminescence distributed periportally in normal and mevinolin-treated rat livers, 5556 Identification of genes and gene products necessary for bacterial Liver uptake of chylomicron remnants with high and low apoprotein E:C bioluminescence, 4154 ratios, 5863 Luteinizing hormone Human alcohol dehydrogenase: Structural differences between the and Estradiol feedback effects on the a-subunit mRNA in the sheep pituitary -y subunits suggest parallel duplications in isoenzyme evolution and gland: Correlation with serum and pituitary luteinizing hormone predominant expression of separate gene descendants in livers of concentrations, 1322 different mammals, 6320 Biological Sciences Subject Index Proc. NatL. Acad. Scd USA 81 (1984) 8097

Spatial relationships of the human chorionic gonadotropin (hCG) subunits Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell in the assembly of the hCG-receptor complex in the luteinized rat lymphoma, 593 ovary, 4667 Proviruses are adjacent to c-myc in some murine leukemia virus-induced Physiological role of a-melanocyte-stimulating hormone in modulating the lymphomas, 2097 secretion of prolactin and luteinizing hormone in the female rat, 8004 Extensive homology exists between Marek disease herpesvirus and its Lutehning hormone-releasing hormone vaccine virus, herpesvirus of turkeys, 3365 Inhibition of growth of pancreatic carcinomas in animal models by Possible DNA-RNA tumor virus interaction in human lymphomas: analogs of hypothalamic hormones, 248 Expression of retroviral proteins in Ramos lymphoma lines is enhanced The goldfish nervus terminalis: A luteinizing hormone-releasing hormone after conversion with Epstein-Barr virus (Correction), 3918 and molluscan cardioexcitatory peptide immunoreactive olfactoretinal Nucleotide sequence 5' of the chicken c-myc coding region: Localization pathway, 940 of a noncoding exon that is absent from myc transcripts in most avian Simultaneous administration of pure antiandrogens, a combination leukosis virus-induced lymphomas, 4697 necessary for the use of luteinizing hormone-releasing hormone Viral integration near c-myc in 10-20%o of MCF 247-induced AKR agonists in the treatment of prostate cancer, 3861 lymphomas, 6808 Long-acting delivery systems for peptides: Inhibition of rat prostate Nucleotide sequence 5' of the chicken c-myc coding region: Localization tumors by controlled release of [D-Trp6]luteinizing hormone-releasing of a noncoding exon that is absent from myc transcripts in most avian hormone from injectable microcapsules, 5845 leukosis virus-induced lymphomas (Correction), 7258 A ligand-specific action of chelated copper on hypothalamic neurons: Expression of differentiation and murine leukemia virus antigens on cells Stimulation of the release of luteinizing hormone-releasing hormone of primary tumors and cell lines derived from chemically induced from median eminence explants, 7656 lymphomas of RF/J mice, 7612 Lutropin Covalently bound myristate in a lymphoma tyrosine protein kinase, 7679 Sulfation of lutropin oligosaccharides with a cell-free system, 5320 Lymphoma cell Lutropin-releasing hormone Identification of the tyrosine protein kinase from LSTRA cells by use of Synthesis and biological activity of human inhibin-like peptide- site-specific antibodies, 6676 (1-31), 5399 Gene transfer in lymphoid cells: Expression of the Thy-1.2 antigen by Lymphoblast Thy-1.1 BW5147 lymphoma cells transfected with unfractionated No evidence for differences in the Epstein-Barr virus genome carried in cellular DNA, 7176 Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from Lymphomagenesis the same patients, 4930 Mechanism of T-cell lymphomagenesis: Transformation of growth-factor- Lymphocyte dependent T-lymphoblastoma cells to growth-factor-independent T- Identification of Epstein-Barr nuclear antigen polypeptide in mouse and lymphoma cells, 1742 monkey cells after gene transfer with a cloned 2.9-kilobase-pair Lymphoproliferative disease subfragment of the genome, 43 Inhibition by restricted-calorie diet of lymphoproliferative disease and Functional T cells in athymic nude mice, 886 renal damage in MRL/lpr mice, 6144 Expression of an immunoglobulin heavy chain gene transfected into lymphocytes, 1292 Lysosomes are associated with microtubules and not with intermediate Membranes from T and B lymphocytes have different patterns of tyrosine filaments in cultured fibroblasts, 788 phosphorylation, 2347 Down-regulation of the epidermal growth factor receptor in KB cells is Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM due to receptor internalization and subsequent degradation in autoantibodies, 2494 lysosomes, 2384 Control of biologically active interleukin 2 messenger RNA formation in Two populations of prelysosomal structures transporting induced human lymphocytes, 2601 asialoglycoproteins in rat liver, 2995 Thymosin increases production of T-cell growth factor by normal human Cathepsin D-mediated processing of procollagen: Lysosomal enzyme peripheral blood lymphocytes, 2882 involvement in secretory processing of procollagen, 3302 Antagonism by taxol of effects of microtubule-disrupting agents on Amino acid sequence of porcine spleen cathepsin D, 3703 lymphocyte cAMP metabolism and cell function, 3496 Accumulation of coated vesicles bearing mannose 6-phosphate receptors Identification of Epstein-Barr virus sequences that encode a nuclear for lysosomal enzymes in the Golgi region of I-cell fibroblasts, 5135 antigen expressed in latently infected lymphocytes, 4373 cDNA clone for the a-chain of human 83-hexosaminidase: Deficiency of Modulation of human lymphocyte responses by low density lipoproteins a-chain mRNA in Ashkenazi Tay-Sachs fibroblasts, 5394 (LDL): Enhancement but not immunosuppression is mediated by LDL Antigen conformation determines processing requirements for T-cell receptors, 4539 activation, 6831 Chemical reduction of oxidized human lymphocytes inhibits interleukin 2 Lysozyme production but not induction of interleukin 2 responsiveness, 5209 Processing of lysozyme by macrophages: Identification of the Liposomes as targets for granule cytolysin from cytotoxic large granular determinant recognized by two T-cell hybridomas, 2489 lymphocyte tumors, 5551 Twisted states of Bacillus subtilis macrofibers reflect structural states of Expression of Epstein-Barr virus (EBV) DNA and cloned DNA the cell wall, 3562 fragments in human lymphocytes following Sendai virus envelope- Lytechinus mediated gene transfer, 5926 Temporal expression of late histone messenger RNA in the sea urchin Cytomegalovirus infects human lymphocytes and monocytes: Virus Lytechinus pictus, 2411 expression is restricted to immediate-early gene products, 6134 Kinetics of thymidine incorporation into detergent-soluble DNA of mouse lymphocytes, 7056 MI RNA Enhancer-dependent expression of human K immunoglobulin genes Tandem promoters preceding the gene for the Ml RNA component of introduced into mouse pre-B lymphocytes by electroporation, 7161 Escherichia coli ribonuclease P, 3959 Recognition of HLA-A2 and -B7 antigens by cloned cytotoxic T Mabuya lymphocytes after gene transfer into human and monkey, but not Eutherian-like reproductive specializations in a viviparous reptile, 4860 mouse, cells, 7549 Macrofiber Lymphocyte activation Twisted states of Bacillus subtilis macrofibers reflect structural states of Intracellular lymphocyte activation and carrier-mediated transport of C8- the cell wall, 3562 substituted guanine ribonucleosides, 862 a2-Macroglobulin Lymphocyte-determined membrane antigen Specific covalent binding of platelet-derived growth factor to human A membrane protein encoded by Epstein-Barr virus in latent growth- plasma a2-macroglobulin, 342 transforming infection, 7207 Specific covalent binding of platelet-derived growth factor to human Lymphocyte membrane plasma a2-macroglobulin (Correction), 2586 Regulation of receptor capping in mouse lymphoma T cells by Ca2+- Plasma binding proteins for platelet-derived growth factor that inhibit its activated myosin light chain kinase, 165 binding to cell-surface receptors, 3424 Lymphoid cell Partial primary structure of human pregnancy zone protein: Extensive Monoclonal derivation of mouse myeloid and lymphoid lineages from sequence homology with human a2-macroglobulin, 7353 totipotent hematopoietic stem cells experimentally engrafted in fetal Macromolecular structure hosts, 7835 Radial distributions of density within macromolecular complexes Lymphoid progenitor cell determined from dark-field electron micrographs, 6363 Hematopoietic cell transformation by a murine recombinant retrovirus Macromolecular system containing the src gene of Rous sarcoma virus, 2374 Self-organization in macromolecular systems: The notion of adaptive Lymphokine value, 6068 Identification and characterization of a monoclonal antibody to an antigen Macrophage expressed on activated macrophages, 4505 Injection of mice with antibody to interferon renders peritoneal Increased expression of Ia antigens on resting B cells: An additional role macrophages permissive for vesicular stomatitis virus and for B-cell growth factor, 6149 encephalomyocarditis virus, 602 Evidence for an intracellular precursor for human B-cell growth Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro, 931 factor, 7902 Thymus-derived lymphocytes and their interactions with macrophages are Human interleukin 2 can promote the growth factor and differentiation of required for the production of osteoclast-activating factor in the B cells in the of 7917 mouse, 2181 single hapten-specific presence specific antigen, Processing of lysozyme by macrophages: Identification of the Lymphoma determinant recognized by two T-cell hybridomas, 2489 Possible DNA-RNA tumor virus interaction in human lymphomas: Suppression of phagocytic function and phospholipid metabolism in Expression of retroviral proteins in Ramos lymphoma lines is enhanced macrophages by phosphatidylinositol liposomes, 2655 after conversion with Epstein-Barr virus, 33 of a conductance in cultured A molecular approach to leukemogenesis: Mouse lymphomas contain an Development delayed outward-rectifying K+ activated c-ras oncogene, 202 mouse peritoneal macrophages, 3083 8098 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 81 (1984)

Tumors undergoing rejection induced by monoclonal antibodies of the Antigen-specific helper T-cell clone supernatant is sufficient to induce IgG2a isotype contain increased numbers of macrophages activated for both polyclonal proliferation and differentiation of small resting B a distinctive form of antibody-dependent cytolysis, 3506 lymphocytes, 6491 Modification of low density lipoprotein by endothelial cells involves lipid Antigen presentation by murine and human cells to a murine T-cell peroxidation and degradation of low density lipoprotein hybridoma: Demonstration of a restriction element associated with a phospholipids, 3883 major histocompatibility complex class II determinant(s) shared by y-Interferon induces expression of the HLA-D antigens on normal and both species, 7559 leukemic human myeloid cells, 4080 Attachment of an anti-receptor antibody to non-target cells renders them The mononuclear phagocyte system of the mouse defined by susceptible to lysis by a clone of cytotoxic T lymphocytes, 7922 immunohistochemical localization of antigen F4/80: Macrophages of or postsynaptic density protein endocrine organs, 4174 Evidence that the major postsynaptic density protein is a component of a Identification and characterization of a monoclonal antibody to an antigen Ca2+/calmodulin-dependent protein kinase, 945 expressed on activated macrophages, 4505 Makisterone Recombinant human y-interferon induces human monocyte polykaryon Evidence for the presence of makisterone A in Drosophila larvae and the formation, 4554 secretion of 20-deoxymakisterone A by the ring gland, 5643 Activation and fusion induced by la,25-dihydroxyvitamin D3 and their Malaria relation in alveolar macrophages, 7112 Protective immunization of the squirrel monkey against asexual blood Colony-stimulating factor (CSF) controls proliferation of CSF-dependent stages of Plasmodium falciparum by use of parasite protein cells by acting during the G1 phase of the cell cycle, 7451 fractions, 229 Necrosin: Purification and properties of a cytotoxin derived from a Comparison of immunity to malaria in Sudan and Indonesia: Crisis-form murine macrophage-like cell line, 7932 versus merozoite-invasion inhibition, 922 Macrophage activation factor Differential antibody screening of cloned Plasmodium falciparum Use of monoclonal antibodies as sensitive and specific probes for sequences expressed in Escherichia coli: Procedure for isolation of biologically active human y-interferon, 5219 defined antigens and analysis of human antisera, 2456 Macrophage-derived growth factor Identification and expression in Escherichia coli of merozoite stage- Macrophage-derived growth factor for osteoblast-like cells and specific genes of the human malarial parasite Plasmodium chondrocytes, 4558 falciparum, 3690 Madin-Darby canine kidney cell Circumsporozoite gene of Plasmodium cynomolgi (Gombak): cDNA Tumor promoters induce a specific morphological signature in the nuclear cloning and expression of the repetitive circumsporozoite epitope, 7520 matrix-intermediate filament scaffold of Madin-Darby canine kidney Human antibodies to a Mr 155,000 Plasmodium falciparum antigen (MDCK) cell colonies, 4409 efficiently inhibit merozoite invasion, 7912 Magnesium Male sterility Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised Streptococcal L-forms isolated from Drosophila paulistorum semispecies extracellular magnesium induce proliferation of chicken heart cause sterility in male progeny, 282 mesenchymal cells, 6418 Genetic basis of male sterility in hybrids between two closely related Intracellular free magnesium in erythrocytes of essential hypertension: species of Drosophila, 4444 Relation to blood pressure and serum divalent cations, 6511 Malignant growth Magnetic susceptibility Malignant growth in the normal host after variant selection in vitro with Comparison of the magnetic properties of deoxy- and photodissociated cytolytic T-cell lines, 2186 myoglobin, 2359 Malsburg synapse Magnetic susceptibility of oxy- and carbonmonoxyhemoglobins, 5417 Function of the thalamic reticular complex: The searchlight Maillard reaction hypothesis, 4586 Aging of proteins: Isolation and identification of a fluorescent Maltose chromophore from the reaction of polypeptides with glucose, 2684 MAL6 of Saccharomyces: A complex genetic locus containing three Maitotoxin genes required for maltose fermentation, 2811 Interactions of maitotoxin with voltage-sensitive calcium channels in Mammalian cell colony cultured neuronal cells, 4582 A mutagen-testing assay based on heterogeneity in diameter and Maize integrated optical density of mammalian cell colonies, 2112 Mechanism of cytoplasmic pH regulation in hypoxic maize root tips and Mammary adenocarcinoma its role in survival under hypoxia, 3379 Expression of an 86-kilodalton glycoprotein in an idiopathic mammary Cloning of the bronze locus in maize by a simple and generalizable adenocarcinoma of a BALB/c mouse, 4159 procedure using the transposable controlling element Activator Mammary carcinosarcoma (Ac), 3825 -A position 12-activated H-ras oncogene in all HS578T mammary Single gene for the large subunit of ribulosebisphosphate carboxylase in carcinosarcoma cells but not normal mammary cells of the same maize yields two differentially regulated mRNAs, 4060 patient, 5384 DNA insertion in the first intron of maize Adhi affects message levels: Mammary cell line Cloning of progenitor and mutant Adhl alleles, 4125 Epithelial mouse mammary cell line exhibiting normal morphogenesis in Regulation of Cat] gene expression in the scutellum of maize during early 4903 vivo and functional differentiation in vitro, 3756 sporophytic development, Mammary epithelial cell Cytoplasmic acidosis as a determinant of flooding intolerance in Serum-free growth of human mammary epithelial cells: Rapid clonal plants, 6029 growth in defined medium and extended serial passage with pituitary Major histocompatibility complex extract, 5435 Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory Mammary gland cells, 1221 Developmental regulation of cytokeratins in cells of the rat mammary Murine leukemia virus are in gland studied with monoclonal antibodies, 1203 sequences encoded the murine major In vivo, cAMP stimulates growth and morphogenesis of mouse mammary histocompatibility complex, 1804 ducts, 4950 Functional and inducible expression of a transfected murine class II major histocompatibiiity complex gene, 2045 Monoclonal antibodies of predefined specificity detect activated ras gene Orientation of loci within the human major histocompatibility complex by expression in human mammary and colon carcinomas, 5227 chromosomal in situ hybridization, 2816 Microvillin: A 200-kilodalton protein in microvilli of rat mammary cells Idiotypic determinants of natural IgM antibodies that resemble self Ia detected by a monoclonal antibody, 5459 antigens, 3175 Lumen formation and redistribution of inframembranous proteins during Genetic control of major histocompatibility complex-linked immune differentiation of ducts in the rat mammary gland, 5763 responses to synthetic polypeptides in man: Poly(L-phenylalanine, Evidence for physiological function of epidermal growth factor: L-glutamic acid)-poly(DL-alanine)--poly(L-lysine) and L-glutamic acid, Pregestational sialoadenectomy of mice decreases milk production and L-alanine, L-tyrosine (60:30:10), 3521 increases offspring mortality during lactation period, 6059 Molecular organization of the HLA-SB region of the human major Man histocompatibility complex and evidence for two SB 13-chain Lengths of chromosomal segments conserved since divergence of man genes, 3934 and mouse, 814 Eukaryotic chromosome transfer: Linkage of the murine major Cellular homologs of the avian erythroblastosis virus erb-A and erb-B histocompatibility complex to an inserted dominant selectable genes are syntenic in mouse but asyntenic in man, 4874 marker, 4879 Manduca Genes for murine fourth complement component (C4) and sex-limited In vitro reprogramming of the photoperiodic clock in an insect brain- protein (Sip) identified by hybridization to C4- and Slp-specific retrocerebral complex, 5881 cDNA, 4908 Manganese 2 Immune interferon activates multiple class II major histocompatibility Mn2+ and Co2+ toxicity in chlorophyll biosynthesis, 476 complex genes and the associated invariant chain gene in human Some plant leaves have orientation-dependent EPR and NMR endothelial cells and dermal fibroblasts, 4917 spectra, 748 Cloning and sequence analysis of the human major histocompatibility Isolation of the Escherichia coli iron superoxide dismutase gene: complex gene DC-3/3, 5199 Evidence that intracellular superoxide concentration does not regulate A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 oxygen-dependent synthesis of the manganese superoxide mutant, 5204 dismutase, 4970 Mep-) gene controlling a kidney metalloendopeptidase is linked to the Molecular mechanisms of manganese mutagenesis, 7378 major histocompatibility complex in mice, 5542 Mannoprotein Homology of adenoviral E3 glycoprotein with HLA-DR heavy Isolation of glucose-containing high-mannose glycoprotein core chain, 6039 oligosaccharides, 6340 Biological Sciences Subject Index Proc. NatL Acad. ScL USA 81 (1984) 8099

Mannom Membrane attack complex Further clues concerning the vectors essential to regulation of hexose Nucleotide sequence of cDNA and derived amino acid sequence of transport, as studied in fibroblast cultures from a metabolic human complement component C9, 7298 mutant, 1126 Membrane, basolateral Mannose 6-phosphate Cell swelling increases a barium-inhibitable potassium conductance in the Uterofemn has N-asparagine-linked high-mannose-type oligosaccharides basolateral membrane of Necturus small intestine, 3591 that contain mannose 6-phosphate, 2985 Membrane biogenesis Mannose 6-phosphate receptor Phosphatidylserine functions as the major precursor of Accumulation of coated vesicles bearing mannose 6-phosphate receptors phosphatidylethanolamine in cultured BHK-21 cells, 2669 for lysosomal enzymes in the Golgi region of I-cell fibroblasts, 5135 Membrane conductance Marek disease virus Movement of ions through fixed pores in the neural membrane, 5609 Extensive homology exists between Marek disease herpesvirus and its A "convertible pore" model of neural membrane conductance, 7238 vaccine virus, herpesvirus of turkeys, 3365 Membrane damage Mass spectrometry Artifacts caused by cell microinjection, 1426 Strategy for the mass spectrometric verification and correction of the Membrane excitability primary structures of proteins deduced from their DNA Dimeric structure of single chloride channels from Torpedo sequences, 1956 electroplax, 2772 Mast cell Membrane fusion Direct demonstration of increased intracellular concentration of free Analysis of Sendai virus mRNAs with cDNA clones of viral genes and calcium as measured by quin-2 in stimulated rat peritoneal mast sequences of biologically important regions of the fusion protein, 7732 cell, 3978 Membrane glycoprotein Adenosine release from stimulated mast cells, 6192 Invasive behavior of mouse sarcoma cells is inhibited by blocking a Mast cell growth factor 37,000-dalton plasma membrane glycoprotein with Fab fragments, 3747 Isolation and characterization of a mouse cDNA clone that expresses Membrane lipid mast-cell growth-factor activity in monkey cells, 1070 Role of membrane lipids in peptide hormone function: Binding of Maternal Inheritance enkephalins to micelles, 61 The persistence of maternal inheritance in Chlamydomonas despite Membrane lipoprotein hypomethylation of chloroplast DNA induced by inhibitors, 3438 Nucleotide sequence of the Escherichia coli prolipoprotein signal Mating pheromone peptidase (isp) gene, 3708 Secretion of foreign proteins from Saccharomyces cerevisiae directed by Membrane penetration a-factor gene fusions, 5330 Mechanism of insertion of diphtheria toxin: Peptide entry and pore size Mating system determinations, 3341 Estimation of mating system parameters when outcrossing events are Membrane potential correlated, 5258 Perpendicular orientation and directional migration of amphibian neural Mating type crest cells in dc electrical fields, 160 Genes required for initiation and resolution steps of mating-type switching Time and voltage windows for reversing the electrical block to in fission yeast, 3481 fertilization, 1436 Maturation-promoting factor Membrane protein In vivo effects of microinjected alkaline phosphatase and its low Chimeric influenza virus hemagglutinin containing either the NH2 molecular weight substrates on the first meiotic cell division in terminus or the COOH terminus of G protein of vesicular stomatitis Xenopus laevis oocytes, 5150 virus is defective in transport to the cell surface, 395 Mechanoelectrical transducer Amino acid sequence homology among the major outer membrane Mechanoelectrical transducer has discrete conductances in the chick proteins of Escherichia coli, 1048 vestibular hair cell, 1888 Ca2+-ATPase of the sarcoplasmic reticulum shares a common domain Mechanoreceptor with a membrane glycoprotein associated with the cytoskeleton of Is ATP a central synaptic mediator for certain primary afferent fibers microvilli, 1130 from mammalian skin?, 6890 Crambin in phospholipid vesicles: Circular dichroism analysis of crystal Medial septal nucleus structure relevance, 1406 Neutotrophic effects of hippocampal extracts on medial septal nucleus in Assembly in vitro of a spanning membrane protein of the endoplasmic vitro, 2567 reticulum: The El glycoprotein of coronavirus mouse hepatitis virus A59, 1421 Melosis Detection of erythrocyte membrane proteins, sialoglycoproteins, and In vivo effects of microinjected alkaline phosphatase and its low lipids in the same polyacrylamide gel using a double-staining molecular weight substrates on the first meiotic cell division in technique, 1733 Xenopus laevis oocytes, 5150 Membrane proteins unique to vertebrate olfactory cilia: Candidates for Identification of a recent recombination event within the human 6-globin sensory receptor molecules, 1859 gene cluster, 7875 The structure of bovine brain myelin proteolipid and its organization in a-Melanocyte-stimulating hormone myelin, 2912 Physiological role of a-melanocyte-stimulating hormone in modulating the Signal recognition particle is required for co-translational insertion of secretion of prolactin and luteinizing hormone in the female rat, 8004 cytochrome P450 into microsomal membranes, 3361 Melanoma Intragenic regions required for LamB export, 3830 Fibroblasts from patients with hereditary cutaneous malignant melanoma Protein 4.1: Its association with the human erythrocyte membrane, 4404 are abnormally sensitive to the mutagenic effect of simulated sunlight Crystallization of reaction center from Rhodopseudomonas sphaeroides: and 4-nitroquinoline 1-oxide, 1179 Preliminary characterization, 4795 Induction of immunity to a human tumor marker by in vivo Isolation and nucleotide sequence of the gene encoding human administration of anti-idiotypic antibodies in mice, 2864 rhodopsin, 4851 T-cell-mediated cytotoxicity against autologous malignant melanoma: Structure and molecular arrangement of proteolipid protein of central Analysis with interleukin 2-dependent T-cell cultures, 3511 nervous system myelin, 5012 Molecular cloning and the total nucleotide sequence of the human c-Ha- Stability of "salt bridges" in membrane proteins, 5412 ras-1 gene activated in a melanoma from a Japanese patient, 4771 Fusion protein of the paramyxovirus simian virus 5: Nucleotide sequence Melanoma cell of mRNA predicts a highly hydrophobic glycoprotein, 6706 Localization of the gangliosides GD2 and GD3 in adhesion plaques and on Synthesis of a major integral membrane protein polypeptide of rat liver the surface of human melanoma cells, 5767 peroxisomes on free polysomes, 7127 Characterization of nerve growth factor receptor in neural crest tumors A membrane protein encoded by Epstein-Barr virus in latent growth- using monoclonal antibodies, 6681 transforming infection, 7207 Membrane Primary structure of the L subunit of the reaction center from Sequence homology and structural similarity between cytochrome b of Rhodopseudomonas sphaeroides, 7303 mitochondrial complex III and the chloroplast b6-f complex: Position of Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal the cytochrome b hemes in the membrane, 674 signal sequence, 7338 Membranes from T and B lymphocytes have different patterns of tyrosine Protein export in Escherichia coli requires a soluble activity, 7737 phosphorylation, 2347 The 64-kilodalton membrane protein of Bacillus subtilis is also present as Effects of Cu deficiency on photosynthetic electron transport, 2369 a multiprotein complex on membrane-free ribosomes, 7772 Defining erythrocyte internal labeling by phosphorylation, 2767 Membrane reconstitution Binding of [3H]forskolin to rat brain membranes, 5081 Reconstitution of a functional synaptosomal membrane possessing the Subunit b of the membrane moiety (FO) of ATP synthase (FIFO) from protein constituents involved in acetylcholine translocation, 277 Escherichia coli is indispensable for H+ translocation and binding of Allogeneic stimulation of cytotoxic T cells by supported planar the water-soluble F1 moiety, 7279 membranes, 6159 Antigen presentation by supported planar membranes containing affinity- Different channel properties of Torpedo acetylcholine receptor monomers purified I-A', 7564 and dimers reconstituted in planar membranes, 6222 Membrane antigen Identification and partial purification of the cardiac sodium-calcium Human T-cell leukemia virus-associated membrane antigens: Identity of exchange protein, 6569 the major antigens recognized after virus infection, 3856 Membrane vesicle Detection of an Epstein-Barr virus-associated membrane antigen in Inhibition of Na+/Ca2' exchange in membrane vesicle and papillary Epstein-Barr virus-transformed nonproducer cells by leukocyte muscle preparations from guinea pig heart by analogs of amiloride, 3238 migration inhibition and blocking antibody, 4178 Isolation of flagellated membrane vesicles from Caulobacter crescentus Serological cross-reactivity between envelope gene products of type I and cells: Evidence for functional differentiation of polar membrane type II human T-cell leukemia virus, 7579 domains, 3409 8100 Biological Sciences Subject Index Proc. NatL. Acad. Scd USA 81 (1984)

Memory Dipyridamole inhibits reversion by thymidine of methotrexate effect and Neurons with graded response have collective computational properties increases drug uptake in Sarcoma 180 cells, 3200 like those of two-state neurons, 3088 Development of methotrexate resistance in a human squamous cell Mfpadione carcinoma of the head and neck in culture (Correction), 5006 3P NMR study of improvement in oxidative phosphorylation by vitamins Accumulation of DNA strand breaks and methotrexate cytotoxicity, 5694 K3 and C in a patient with a defect in electron transport at complex III Methotrexate resistance in skeletal muscle, 3529 Chromosomal organization of the human dihydrofolate reductase genes: Meprin Dispersion, selective amplification, and a novel form of Mep-1 gene controlling a kidney metalloendopeptidase is linked to the polymorphism, 5170 major histocompatibility complex in mice, 5542 Methoxyverapamil Mercury Charge movement in skeletal muscle fibers paralyzed by the calcium- Mercury selection of allozymes in marine organisms: Prediction and entry blocker D600, 2582 verification in nature, 1258 Methyl-accepting chemotaxis protein Mercuric ion-resistance operons of plasmid R100 and transposon TnSO1: Sensory transduction in Escherichia coli: Regulation of the demethylation The beginning of the operon including the regulatory region and the rate by the CheA protein, 5061 first two structural genes, 5975 N2-Methyl-9-hydroxyelliptlcinlum acetate Merocyanine 540 Regioselective arylation of ribose in adenosine and guanosine with the Selective killing of leukemic cells by merocyanine 540-mediated antitumor drug N2-methyl-9-hydroxyellipticinium acetate, 1297 photosensitization, 7584 N-Methyl-N-nitrosourea Meromyosin Induction of replicative DNA synthesis in quiescent human fibroblasts by Catalytic consequences of oligomeric organization: Kinetic evidence for DNA damaging agents, 4828 "tethered" acto-heavy meromyosin at low ATP concentrations, 5345 N-Methyl-4phenyl-1,2,3,6-tetrahydropyridine Merozoite Parkinsomsm-inducing neurotoxin, N-methyl4-phenyl-1,2,3,6- Comparison of immunity to malaria in Sudan and Indonesia: Crisis-form tetrahydropyridine: Characterization and localization of receptor versus merozoite-invasion inhibition, 922 binding sites in rat and human brain, 4591 Identification and expression in Escherichia coli of merozoite stage- N'-Methyladenosine specific genes of the human malarial parasite Plasmodium Mapping of N6-methyladenosine residues in bovine prolactin falciparum, 3690 mRNA, 5667 Human antibodies to a Mr 155,000 Plasmodium falciparum antigen Methylamine efficiently inhibit merozoite invasion, 7912 Lens transglutaminase selects specific ,B-crystallin sequences as Messenger RNA substrate, 7017 See mRNA Meth las Metabolic rate DNA methylation pattern is determined by the intracellular level of the Thymine glycol and thymidine glycol in human and rat urine: A possible methylase, 3278 assay for oxidative DNA damage, 5633 N-Methylaspartate Metacyclic trypanosome Selective association of N-methyl aspartate and quisqualate types of L- Characterization of the genes specifying two metacyclic variable antigen glutamate receptor with brain postsynaptic densities, 6876 types in Trypanosoma brucei rhodesiense, 6642 Methylation Metal Insulin stimulation of phospholipid methylation in isolated rat adipocyte Induction of mouse metallothionein-I mRNA by bacterial endotoxin is plasma membranes, 1089 independent of metals and glucocorticoid hormones, 1053 Analysis of the pleiotropic regulation of flagellar and chemotaxis gene Human metallothionein genes are clustered in chromosome 16, 5494 expression in Caulobacter crescentus by using plasmid Modulation of cholecystokinin concentrations in the rat hippocampus by complementation, 1341 chelation of heavy metals, 5876 Albumin extinction without methylation of its gene, 1738 Mercuric ion-resistance operons of plasmid R100 and transposon TnS01: Differential methylation of hypoxanthine phosphoribosyltransferase genes The beginning of the operon including the regulatory region and the on active and inactive human X chromosomes, 1759 first two structural genes, 5975 Variations in DNA methylation during mouse cell differentiation in vivo Metailoendopeptidase and in vitro, 2275 Mep-1 gene controlling a kidney metalloendopeptidase is linked to the Methyl transfer from methylcobalamin to diaquocobinamide, 2698 major histocompatibility complex in mice, 5542 Methylation of the hypoxanthine phosphoribosyltransferase locus on the Metallothionein human X chromosome: Implications for X-chromosome Induction of mouse metallothionein-I mRNA by bacterial endotoxin is inactivation, 2806 independent of metals and glucocorticoid hormones, 1053 DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' Copper metallothionein of yeast, structure of the gene, and regulation of region inactivate the E2a gene of adenovirus type 2, 2950 expression, 3332 Differentiation of myoblast cell lines and biological methylation: 3- Human metallothionein genes are clustered in chromosome 16, 5494 Deazaadenosine stimulates formation of multinucleated myofibers, 3064 A 12-base-pair DNA motif that is repeated several times in In Z-DNA the sequence G-C-G-C is neither methylated by Hha I metallothionein gene promoters confers metal regulation to a methyltransferase nor cleaved by Hha I restriction endonuclease, 3268 heterologous gene, 7318 Inhibitors of CDP-choline synthesis, action potential calcium channels, Duplicated heavy metal control sequences of the mouse metallothionein-I and stimulus-secretion coupling, 4353 gene, 7392 Sensory transduction in Escherichia coli: Regulation of the demethylation Metastasis rate by the CheA protein, 5061 Alteration of neural cell adhesion molecule (N-CAM) expression after Mammalian brain and erythrocyte carboxyl methyltransferases are similar neuronal cell transformation by Rous sarcoma virus, 969 enzymes that recognize both D-aspartyl and L-isoaspartyl residues in Tumor cell proteinase visualization and quantification using a fluorescent structurally altered protein substrates, 7757 transition-state analog probe, 1135 3-Methylcholanthrene Induction of the metastatic phenotype in a mouse tumor model by Coding nucleotide sequence of 3-methylcholanthrene-inducible 5-azacytidine, and characterization of an antigen associated with cytochrome P-450d cDNA from rat liver, 1649 metastatic activity, 3389 Structures of cysteine-containing peptides in isosafrole-inducible rat Differential adhesion of tumor cells to capillary endothelial cells in hepatic microsomal cytochrome P-450d: Sequence homology with 3- vitro, 5739 methylcholanthrene-induced cytochrome P-450c, 4298 Metazoan Distinct organization of methylcholanthrene- and phenobarbital-inducible "Hopeful monsters," transposons, and Metazoan radiation, 5482 cytochrome P-450 genes in the rat, 5066 Methanobacterium Expression of differentiation and murine leukemia virus antigens on cells Formaldehyde activation factor, tetrahydromethanopterin, a coenzyme of of primary tumors and cell lines derived from chemically induced methanogenesis, 1976 lymphomas of RF/J mice, 7612 Methanococcus Methylcobalamin Distribution of two selenonucleosides among the selenium-containing Methyl transfer from methylcobalamin to diaquocobinamide, 2698 tRNAs from Methanococcus vannielii, 57 5-Methylcytosine Methanogenesis Covalent bond formation between a DNA-cytosine methyltransferase and FormMadehyde activation factor, tetrahydromethanopterin, a coenzyme of DNA containing 5-azacytosine, 6993 methanogenesis, 1976 O'-Methylguanine Construction and characterization of extrachromosomal probes for Methanopterin mutagenesis by carcinogens: Site-specific incorporation of o6- Formaldehyde activation factor, tetrahydromethanopterin, a coenzyme of methylguanine into viral and plasmid genomes, 13 methanogenesis, 1976 Adaptive response in mammalian cells: Crossreactivity of different Methanosarcina pretreatments of cytotoxicity as contrasted to mutagenicity, 1062 Major heat shock gene of Drosophila and the Escherichia coli heat- In vivo mutagenesis by 06-methylguanine built into a unique site in a viral inducible dnaK gene are homologous, 848 genome, 6271 Methidlumpropyl-EDTA Fe(II) Methylthioadenosine phosphorylase RNA structure analysis using methidiumpropyl-EDTA*Fe(II): A base- Assignment of the gene for methylthioadenosine phosphorylase to human pair-specific RNA structure probe, 6978 chromosome 9 by mouse-human somatic cell hybridization, 2665 Methotrexate N-Methylthlotetrazole Selective killing of Fc-receptor-bearing tumor cells through endocytosis Mechanism of the inhibition of the y-carboxylation of glutamic acid by N- of a drug-carrying immune complex, 1445 methylthiotetrazole-containing 2893 Development of methotrexate resistance in a human squamous cell antibiotics, carcinoma of the head and neck in culture, 2873 Methyltransferase Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine, 6993