MOLECULAR AND CELLULAR BIOLOGY Volume 9 November 1989 No. 11

GENE EXPRESSION Mutations in the RBJ Gene and Their Effects on Transcription. J. M. Dunn, R. A. Phillips, X. Zhu, A. Becker, and B. L. Gallie ...... 4596-4604 Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway. Sandra Pellegrini, Joseph John, Moira Shearer, Ian M. Kerr, and George R. Stark ...... 4605-4612 Role of Intron Splicing in the Function of the MATal Gene of Saccharomyces cerevisiae. Sarbjit S. Ner and Michael Smith ...... 4613-4620 The HML Mating-Type Cassette of Saccharomyces cerevisiae Is Regulated by Two Separate but Functionally Equivalent Silencers. Deborah J. Mahoney and James R. Broach...... 4621-4630 Mechanism of Suppression of the Long Terminal Repeat of Moloney Leukemia Virus in Mouse Embryonal Carcinoma Cells. Toshio Tsukiyama, Ohtsura Niwa, and Kenjiro Yokoro...... 4670-4676 Isolation of Constitutive Mutations Affecting the Proline Utilization Pathway in Saccharomyces cerevisiae and Molecular Analysis of the PUT3 Transcrip- tional Activator. Judith E. Marczak and Marorie C. Brandriss ...... 4696-4705 The Saccharomyces cerevisiae PUT3 Activator Protein Associates with Proline- Specific Upstream Activation Sequences. Ayesha H. Siddiqui and Marjorie C. Brandriss...... 4706-4712 Multiple Components Are Required for Sequence Recognition of the AP1 Site in the Gibbon Ape Leukemia Virus Enhancer. John P. Quinn, A. Rosella Farina, Kevin Gardner, Henry Krutzsch, and David Levens ...... 4713-4721 trans Activation of Granulocyte-Macrophage Colony-Stimulating Factor and the Interleukin-2 Receptor in Transgenic Mice Carrying the Human T-Lympho- tropic Virus Type 1 tax Gene. Jeffrey E. Green, C. Glenn Begley, David K. Wagner, Thomas A. Waldmann, and Gilbert Jay ...... 4731-4737 Processing of 9E3 mRNA and Regulation of Its Stability in Normal and Rous Sar- coma Virus-Transformed Cells. Mark Y. Stoeckle and Hidesaburo Hanafusa ...... 4738-4745 Activation of Yeast Polymerase II Transcription by Herpesvirus VP16 and GAL4 Derivatives In Vitro. Daniel I. Chasman, Janet Leatherwood, Michael Carey, Mark Ptashne, and Roger D. Kornberg ...... 4746-4749 The Rat Albumin Promoter Is Composed of Six Distinct Positive Elements within 130 Nucleotides. Philippe Herbomel, Anna Rollier, Frangois Tronche, Marie-Odile Ott, Moshe Yaniv, and Mary C. Weiss...... 4750-4758 The Rat Albumin Promoter: Cooperation with Upstream Elements Is Required When Binding of APF/HNF1 to the Proximal Element Is Partially Impaired by Mutation or Bacterial Methylation. Francois Tronche, Anna Rollier, Ingolf Bach, Mary C. Weiss, and Moshe Yaniv ...... 4759-4766 Basal-Level Expression of the Yeast HSP82 Gene Requires a Heat Shock Regula- tory Element. DeAnn McDaniel, Avrom J. Caplan, Myeong-Sok Lee, Christopher C. Adams, Barbara R. Fishel, David S. Gross, and William T. Garrard ...... 4789-4798

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The ras-Like Protein p25rab3A Is Partially Cytosolic and Is Expressed Only in Neural Tissue. Ethan Burstein and Ian G. Macara...... 4807-4811 UV-Induced Early-Domain Binding Factor as the Limiting Component of Simian Virus 40 DNA Amplification in Rodent Cells. Christine Lucke-Huhle, Sabine Mai, and Peter Herrlich...... 4812-4818 Characterization of Phytochrome-Regulated Gene Expression in a Photoauto- trophic Cell Suspension: Possible Role for Calmodulin. Eric Lam, Mark Benedyk, and Nam-Hai Chua ...... 4819-4823 Enhancer and Silencerlike Sites within the Transcribed Portion of a Ty2 Trans- posable Element of Saccharomyces cerevisiae. Philip Farabaugh, Xiao-Bei Liao, Michael Belcourt, Hong Zhao, James Kapakos, and Jeffrey Clare..... 4824 4834 Transcription from a Murine T-Cell Receptor VD1 Promoter Depends on a Con- served Decamer Motif Similar to the Cyclic AMP Response Element. Steven J. Anderson, Shinichi Miyake, and Dennis Y. Loh...... 4835-4845 Regulation of Type I (Epidermal) Transglutaminase mRNA Levels during Squamous Differentiation: Down-Regulation by Retinoids. E. Elizabeth Floyd and Anton M. Jetten ...... 4846-4851 The 216-Nucleotide Intron of the ElA Pre-mRNA Contains a Hairpin Structure That Permits Utilization of Unusually Distant Branch Acceptors. Karim Chebli, Renata Gattoni, Philippe Schmitt, Georges Hildwein, and James Stevenin ...... 4852-4861 A Specific 31-Nucleotide Domain of Ul RNA Directly Interacts with the 70K Small Nuclear Ribonucleoprotein Component. Charles C. Query, Rex C. Bentley, and Jack D. Keene ...... 4872-4881 Arginine Restriction Induced by 8-N-(Phosphonacetyl)-L-Ornithine Signals In- creased Expression of HIS3, TRP5, CPA], and CPA2 in Saccharomyces cere- visiae. Dennis M. Kinney and Carol J. Lusty ...... 4882-4888 Functional Serum Response Elements Upstream of the Growth Factor-Inducible Gene zif268. Barbara Christy and Daniel Nathans ...... 4889-4895 Developmental Appearance of Transcription Factors That Regulate Liver-Specific Expression of the Aldolase B Gene. Ken-Ichi Tsutsumi, Kikukatsu Ito, and Kiichi Ishikawa...... 4923-4931 DNA Damage Induction of Ribonucleotide Reductase. Stephen J. Elledge and Ronald W. Davis ...... 4932-4940 Human Transcription Factor TFIIIC2 Specifically Interacts with a Unique Se- quence in the Xenopus laevis 5S rRNA Gene. Lee G. Fradkin, Steven K. Yoshinaga, Arnold J. Berk, and Asim Dasgupta...... 4941-4950 Sequences Upstream of AAUAAA Influence Poly(A) Site Selection in a Complex Transcription Unit. James D. DeZazzo and Michael J. Imperiale...... 4951-4961 Rearrangement and Diversification of Immunoglobulin Light-Chain Genes in Lymphoid Cells Transformed by Reticuloendotheliosis Virus. Jiayou Zhang, William Bargmann, and Henry R. Bose, Jr...... 4970-4976 Unusual Enhancer Function in Yeast rRNA Transcription. Stewart P. Johnson and Jonathan R. Warner...... 4986-4993 Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo. Michael C. Blake and Jane Clifford Azizkhan ...... 4994-5002 Transcription Factor IIIA Gene Expression in Xenopus Oocytes Utilizes a Tran- scription Factor Similar to the Major Late Transcription Factor. Robert K. Hall and William L. Taylor ...... 5003-5011

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A New Myocyte-Specific Enhancer-Binding Factor That Recognizes a Conserved Element Associated with Multiple Muscle-Specific Genes. Lani A. Gossett, David J. Kelvin, Edward A. Stemnberg, and Eric N. Olson ...... 5022-5033 Mutational Analysis of the Saccharomyces cerevisiae SNF1 Protein Kinase and Evidence for Functional Interaction with the SNF4 Protein. John L. Celenza and Marian Carlson ...... 5034-5044 Molecular Analysis of the SNF4 Gene of Saccharomyces cerevisiae: Evidence for Physical Association of the SNF4 Protein with the SNF1 Protein Kinase. John L. Celenza, Francis J. Eng, and Marian Carlson...... 5045-5054 Regulation of Interaction of the Iron-Responsive Element Binding Protein with Iron-Responsive RNA Elements. David J. Haile, Matthias W. Hentze, Tracey A. Rouault, Joe B. Harford, and Richard D. Klausner ...... 5055-5061 cDNA Structures and Regulation of Two Interferon-Induced Human Mx Proteins. Markus Aebi, Jurg Fah, Nicole Hurt, Charles E. Samuel, Daniel Thomis, Luigi Bazzigher, Jovan Pavlovic, Otto Haller, and Peter Staeheli 5062-5072 Context Effects and Inefficient Initiation at Non-AUG Codons in Eucaryotic Cell- Free Translation Systems. Marilyn Kozak...... 5073-5080 The Xenopus Ribosomal DNA 60- and 81-Base-Pair Repeats Are Position-Depen- dent Enhancers That Function at the Establishment of the Preinitiation Com- plex: Analysis In Vivo and in an Enhancer-Responsive In Vitro System. Louise K. Pape, Jolene J. Windle, Ed B. Mougey, and Barbara Sollner- Webb...... 5093-5104 Evidence that Xeroderma Pigmentosum Cells from Complementation Group E Are Deficient in a Homolog of Yeast Photolyase. Mark Patterson and Gilbert Chu ...... 5105-5112 Expression of the Glycoprotein Hormone oa-Subunit Gene in the Placenta Requires a Functional Cyclic AMP Response Element, whereas a Different cis-Acting Element Mediates Pituitary-Specific Expression. Joseph A. Bokar, Ruth A. Keri, Todd A. Farmerie, Robert A. Fenstermaker, Bogi Andersen, Debora L. Hamernik, June Yun, Thomas Wagner, and John H. Nilson ...... 5113-5122 A Nuclease-Hypersensitive Element of the Human c-myc Promoter Interacts with a Transcription Initiation Factor. E. H. Postel, S. E. Mango, and S. J. Flint...... 5123-5133 Circumstances and Mechanisms of Inhibition of Translation by Secondary Struc- ture in Eucaryotic mRNAs. Marilyn Kozak ...... 5134-5142 Nuclear Factor EF-1A Binds to the Adenovirus ElA Core Enhancer Element and to Other Transcriptional Control Regions. Joseph T. Bruder and Patrick Hearing ...... 5143-5153 Expression from the Transferrin Gene Promoter in Transgenic Mice. Rejean L. Idzerda, Richard R. Behringer, Manfred Theisen, Jodi I. Huggenvik, G. Stanley McKnight, and Ralph L. Brinster ...... 5154-5162 UV-Induced DNA Damage Is an Intermediate Step in UV-Induced Expression of Human Immunodeficiency Virus Type 1, Collagenase, c-fos, and Metallothio- nein. Bernd Stein, Hans Jobst Rahmsdorf, Anja Steffen, Margarethe Litfin, and Peter Herrlich ...... 5169-5181 A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus. Hsiao-Kuey Chang, Bin-Ying Wang, Chiou-Hwa Yuh, Chia-Lin Wei, and Ling-Pai Ting ...... 5189-5197

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Two Chicken Erythrocyte Band 3 mRNAs Are Generated by Alternative Tran- scriptional Initiation and Differential RNA Slicing. Hyeong-Reh Choi Kim, Brenda Schafer Kennedy, and James Douglas Engel...... 5198-5206 Evidence for Multiple Major Histocompatibility Class II X Box Binding Proteins. Antonio Celada and Richard Maki ...... 5219-5222 c-fos and Tumor Necrosis Factor Gene Expression in Leishmania donovani- Infected Macrophages. Albert Descoteaux and Greg Matlashewski ...... 5223-5227 Yeast Repressor at2 Binds to Its Operator Cooperatively with Yeast Protein Mcml. Cynthia A. Keleher, Steven Passmore, and Alexander D. Johnson 5228-5230 A Gamma Interferon-Unresponsive Variant of Cell Line 70Z/3, IFN-4, Can Be Partially Rescued by Phorbol Myristate Acetate. David W. Emery, John W. Rooney, and Carol Hopkins Sibley ...... 5231-5233 The 5' Noncoding Region of the Human Leukemia-Associated Oncogene BCRIABL Is a Potent Inhibitor of In Vitro Translation. Alexander J. Muller and Owen N. Witte...... 5234-5238 Transcriptional Induction of the Murine c-rel Gene with Serum and Phorbol-12- Myristate-13-Acetate in Fibroblasts. Paulina Bull, Tony Hunter, and Inder M. Verma...... 5239-5243 trans Activation of Rat Phosphoenolpyruvate Carboxykinase (GTP) Gene Expres- sion by Micro-Coinjection of Rat Liver mRNA in Xenopus laevis Oocytes. Nissim Benvenisty, Tsipora Shoshani, Yigal Farkash, Hermona Soreq, and Lea Reshef...... 5244 5247 ElA-Induced Enhancer Activity of the Poly(dG-dT) Poly(dA-dC) Element (GT Element) and Interactions with a GT-Specific Nuclear Factor. David T. Berg, Jenna D. Walls, Anne E. Reifel-Miller, and Brian W. Grinnell...... 5248-5253 RNA Polymerase II Transcription Termination Is Mediated Specifically by Pro- tein Binding to a CCAAT Box Sequence. Sheila Connelly and James L. Manley ...... 5254-5259

CELL GROWTH AND DEVELOPMENT Response of Bone Marrow Stromal Cells to Adipogenic Antagonists. Jeffrey Martin Gimble, Marie-Annette Dorheim, Qi Cheng, Phillip Pekala, Sven Enerback, Larry Ellingsworth, Paul W. Kincade, Chi-Sun Wang...... 4587-4595 Identification of a cis-Acting Element Controlling Induction of Early Gene Expression in Dictyostelium discoideum. Thomas May, Hedi Kern, Annette Muller-Taubenberger, and Wolfgang Nellen...... 4653-4659 Identification of a Signal Transduction Response Sequence Element Necessary for Induction of a Dictyostelium discoideum Gene by Extracellular Cyclic AMP. Jovan Pavlovic, Bodduluri Haribabu, and Robert P. Dottin...... 4660-4669 Infection with the Intracellular Protozoan Parasite Theileria parva Induces Consti- tutively High Levels of NF-KcB in Bovine T Lymphocytes. Vladimir Ivanov, Bernd Stein, Ina Baumann, Dirk A. E. Dobbelaere, Peter Herrlich, and Richard 0. Williams...... 4677-4686 The Human Homolog of the JE Gene Encodes a Monocyte Secretory Protein. Barrett J. Rollins, Peter Stier, Timothy Ernst, and Gordon G. Wong ...... 4687-4695 Expression of the MyoDI Muscle Determination Gene Defines Differentiation Ca- pability but Not Tumorigenicity of Human Rhabdomyosarcomas. Alan L. Hiti, Emil Bogenmann, Felicidad Gonzales, and Peter A. Jones...... 4722-4730

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Detection and Characterization of the Fibroblast Growth Factor-Related Onco- protein INT-2. Mark Dixon, Richard Deed, Piers Acland, Robert Moore, Anthony Whyte, Gordon Peters, and Clive Dickson ...... 4896-4902 Tyrosine Phosphorylation of a c-src-Like Protein Is Increased in Membranes of CD4- CD8- T Lymphocytes from lprllpr Mice. T. Katagiri, J. P.-Y. Ting, Ruth Dy, Carol Prokop, Philip Cohen, and H. Shelton Earp...... 4914 4922 Serum-Inducible Expression of Transfected Human c-myc Genes. Adam Richman and Adrian Hayday...... 4962-4969 Induction of Macrophage Colony-Stimulating Factor-Dependent Growth and Dif- ferentiation after Introduction of the Murine c-fms Gene into FDC-P1 Cells. Larry R. Rohrschneider and Donald Metcalf...... 5081-5092 Molecular Cloning of mtp7O, a Mitochondrial Member of the hsp7O Family. David M. Engman, Louis V. Kirchhoff, and John E. Donelson ...... 5163-5168 Induction of a Mitogen-Responsive Gene after Expression of the Ha-ras Oncogene in NIH 3T3 Fibroblasts. A. K. Werenskiold, S. Hoffmann, and R. Klemenz ...... 5207-5214 Inhibition by Phospholipids of the Interaction between R-ras, Rho, and Their GTPase-Activating Proteins. Men-Hwei Tsai, Alan Hall, and Dennis W. Stacey ...... 5260-5264 hsp26 of Saccharomyces cerevisiae Is Related to the Superfamily of Small Heat Shock Proteins but Is without a Demonstrable Function. Ronald E. Susek and Susan L. Lindquist...... 5265-5271

CELL AND ORGANELLE STRUCTURE AND ASSEMBLY Nuclear Gene for Mitochondrial Leucyl-tRNA Synthetase of Neurospora crassa: Isolation, Sequence, Chromosomal Mapping, and Evidence That the leu-S Locus Specifies Structural Information. C. Ming Chow, Robert L. Metzenberg, and Uttam L. Rajbhandary...... 4631-4644 Regulation of the Nuclear Genes Encoding the Cytoplasmic and Mitochondrial Leucyl-tRNA Synthetases of Neurospora crassa. C. Ming Chow and Uttam L. Rajbhandary ...... 4645-4652 Isolation and Characterization of an Extragenic Suppressor of the Low-Density Lipoprotein Receptor-Deficient Phenotype of a Chinese Hamster Ovary Cell Mutant. Pranhitha Reddy and Monty Krieger...... 4799-4806 Mutations in the Signal Sequence of Prepro-ft-Factor Inhibit Both Translocation into the Endoplasmic Reticulum and Processing by Signal Peptidase in Yeast Cells. Daniel S. Allison and Elton T. Young...... 4977-4985 Role of Glutamic Acid 177 of the Ricin Toxin A Chain in Enzymatic Inactivation of Ribosomes. David Schlossman, David Withers, Philip Welsh, Audrey Alexander, Jon Robertus, and Arthur Frankel...... 5012-5021 Spore Coat Genes SP60 and SP70 of Dictyostelium discoideum. Kathy L. Fosnaugh and William F. Loomis...... 5215-5218

CHROMOSOME STRUCTURE AND DYNAMICS Interactions between Yeast Photolyase and Nucleotide Excision Repair Proteins in Saccharomyces cerevisiae and Escherichia coli. Gwendolyn B. Sancar and Frances W. Smith...... 4767-4776

Continued on following page Continuedfrom preceding page Photolyases from Saccharomyces cerevisiae and Escherichia coli Recognize Com- mon Binding Determinants in DNA Containing Pyrimidine Dimers. Mark Baer and Gwendolyn B. Sancar ...... 4777-4788 Degradation of Linear DNA by a Strand-Specific Exonuclease Activity in Xenopus laevis Oocytes. Ed Maryon and Dana Carroll...... 4862-4871 Amplified N-myc in Human Neuroblastoma Cells Is Often Arranged as Clustered Tandem Repeats of Differently Recombined DNA. Lukas C. Amler and Manfred Schwab...... 4903-4913 Antifolate Drug Selection Results in Duplication and Rearrangement of Chromo- some 7 in Plasmodium chabaudi. Alan F. Cowman and Andrew M. Lew 5182-5188

ERRATUM Prosomes and Heat Shock Complexes in Drosophila melanogaster Cells. Cezar Martins de Sa, Emmanuelle Rollet, Maria-Fatima Grossi de Sa, Robert M. Tanguay, Martin Best-Belpomme, and Klaus Scherrer ...... 5272

Date of Issue: 24 October 1989