CURRICULUM VITAE (Abbreviated) JEREMY E. WULFF Department of , University of Victoria

1. EDUCATION and TRAINING a. Degrees Held degree institution year obtained PhD University of Calgary 2004 BSc (Hons., Co-op) University of Victoria 1999 b. Postdoctoral Experience

NSERC Postdoctoral fellow, Harvard University 2005-2007

2. SELECTED POSITIONS HELD PRIOR to APPOINTMENT at UVic period company, job title, duties 1999 : 01-06 Methylgene, research assistant, synthetic organic methodology 1998 : 05-08 Dept. of National Defense, analytical , ICP-MS analysis 1997 : 05-08 Merck Frosst , research assistant, natural product total synthesis

3. ACADEMIC APPOINTMENTS period rank academic unit 07/2007-06/2013 Assistant Professor (renewed 2009) UVic Chemistry 07/2013- Associate Professor with Tenure UVic Chemistry

4. SIGNIFICANT ADMINISTRATIVE or LEADERSHIP ROLES period role 2013- Director, Chemistry for the Medical Sciences BSc Program 2015- Director, CAMTEC Facility for Biomolecular Sample Preparation

5. HONOURS and AWARDS

5a. Recent Awards (since Appointment at UVic): 2012-2022: Canada Research Chair (Tier II) in Bioactive Small Molecule Synthesis [Renewed in 2017] 2011-2019: Michael Smith Foundation for Health Research Career Scholar Award [Renewed in 2016] 2014: Thieme Chemistry Journal Award Top-20-Under-40 on Island [Only academic awarded since the re-launch of the program] 2015: Selected for a Synform Young Career Focus Article [7th researcher worldwide selected for summary]

5b. Earlier Fellowships and Awards: NSERC PDF, John Kendall Thesis Award, I.W. Killam Memorial Scholarship, AHFMR Studentship, NSERC PGSA and PGS-B, Don Tavares Teaching Excellence Award.

page 1 of 9 CURRICULUM VITAE (Abbreviated) 6. MAJOR FIELD(S) of SCHOLARLY or PROFESSIONAL INTEREST

Organic synthesis, medicinal chemistry, chemical biology, synthetic polymers

7. RESEARCH GROUP

7a. Current Research Group: group member program period supervised primary project CAMTEC Facility for Biomolecular Michael Gignac Research Associate Apr 16 – Sample Preparation (FBS) Manager Block copolymers of functionalized Tyler Cuthbert PDF Mar 17 – polydicyclopentadiene Thiele’s esters and neuraminidase Jun Chen PhD Sept 13 – inhibitors

Ronan Hanley** PhD Sept 13 – Small-molecule PD1/PDL1 inhibitors

Tong Li PhD Sept 16 – Functionalized polydicyclopentadiene

Synthesis of tricyclic sulfones for Andy Un MSc Jan 17 – biological testing

Jon Sader MSc Sept 17 – Oxasteroid synthesis

Katherine Krause BSc May 17 – Synthesis of MRI1 inhibitors ** Jointly supervised with Prof. Fraser Hof

7b. MSc and PhD Graduates: group member period supervised primary project post-graduate positions Thomas Doerksen, Cytotoxic MTAP Completing a PhD at Guelph University Sept 15 – Aug 16 MSc substrates (Philosophy of Science) Neuraminidase inhibitors Postdoc with Weaver (TWRI), then Mike Brant, PhD May 09 – Jul 15 from bicyclic sulfones Associate Scientist, Zymeworks Jason Davy, Synthesis of the Researcher with Pharmaster labs Sept 08 – Dec 14 PhD didemnaketal core then Gilead Pharma (Edmonton) Natasha O’Rourke, Rearrangements of Postdoc, Micalizio group, Dartmouth Sept 08 – Dec 14 PhD oligovinyl ethers (NH) Katherine Davies, Synthesis and properties Senior Proposal Writer, PRA July 07 – June 12 PhD of oligovinyl ethers International Caleb Bromba, Synthesis of molecular Aug 07 – Aug 12 Organics Analyst, AGAT Labs PhD probes

7c. Other Group Alumni:

• 42 past undergraduate students (2007–2017) • 1 past MSc exchange student (2007–2017) • 5 past research associates (2007–2017)

7d. Research Group Fellowships and Awards: (national awards only)

Boehringer Ingelheim Cooperative Research Scholarship to Jason Davy, CIHR Master’s Fellowship to Mike Brant, NSERC CGS-M and PGS-D3 to Natasha O’Rourke, NSERC CGS-M to Thomas Doerksen.

page 2 of 9 CURRICULUM VITAE (Abbreviated) 8. RESEARCH GRANTS (since UVic appointment)

8a. Research Operating Grants (continued on next page):

grant holders value agency / award title time period (indicate PI) (to J. Wulff) NSERC Discovery Grant J. Wulff 2016-2021 $225,000 Total synthesis of unnatural products UVic Canada Research Chair J. Wulff 2012-2022 $100,000 Research Supplement Michael Smith Foundation for Health 2011-2019 J. Wulff $120,000 Research Incentive Award [renewed 2016] UVic MSFHR Career Award J. Wulff 2012-2019 $157,500 Research Supplement M. Moffitt* C. Allen, C. Bohne, NSERC CREATE Grant $1,650,000 Polymer nanoparticles for drug delivery J. Oh, M.-A. Fortin, 2017-2023 ($82,500) (POND) M. Bazalova-Carter, J. Wulff, R. Reilly NSERC Idea to Innovation Grant Functionalized polydicyclopentadiene: J. Wulff 2017-2018 $125,000 reduction to commercially viable practice ACS PRF Grant J. Wulff 2017-2019 US$110,000 Functionalized polydicyclopentadiene UVic Internal Research Seed Grant M. Akbari* A smart drug-delivery implant for management 2017-2018 $10,000 of glioblastoma multiforme J. Wulff NSERC Engage Grant J. Wulff* High-level characterization of the effects of 2016-2017 $25,000 de-icing salts on polymer composite insulator R. Padmawar shed hydrophobicity and monomer leakage CCSRI Innovation Grant Y. Wang* $198,018 Identification of lead compounds of cytotoxic J. Wulff, 2014-2016 MTAP substrates for treatment of MTAP- ($61,500) deficient cancers H. Cheng N. Abraham* CCSRI Innovation Grant $200,000 Therapeutic targeting of the IL-7Ra pathway in J. Wulff 2014-2017 ($45,000) acute lymphoblastic leukemia M. Boulanger Prostate Cancer Canada Movember Grant F. Hof* $200,000 Developing small-molecule antagonists of J. Wulff 2013-2015 chromobox 7 (CBX7) as epigenetic therapies ($50,000) for aggressive prostate cancer M. Cox J. Wulff* CCSRI Innovation Grant F. Hof, J. An Small-molecule inhibitors of the PD1-PDL1 2013-2015 $200,000 interaction for treating metastatic cancer M. Boulanger B. Nelson

page 3 of 9 CURRICULUM VITAE (Abbreviated) grant holders value agency / award title time period (indicate PI) (to J. Wulff) Cancer Research Society Operating Grant J. Wulff* C. Cairo Selective inhibitors of human neuraminidase 2012-2014 $120,000 NEU3 as potential therapeutics for castration- M. Boulanger resistant prostate cancer Y. Wang NSERC Discovery Synthesis and evaluation of scaffolds to control J. Wulff 2011-2016 $175,000 -protein and protein-DNA interactions Prostate Cancer Canada Pilot Grant F. Hof* $120,000 Small molecule disruptors of J. Wulff, 2011-2013 EZH2/H3K27me3/CBX7 signaling as targeted ($30,000) therapies for highly aggressive prostate cancer P. Howard J. Wulff* $100,000 CIHR Bridge Funding 2010-2012 Treating drug-resistant influenza M. Boulanger ($65,000) Boehringer Ingelheim Cooperative J. Davy* $60,000 Research Award 2010-2013 Synthesis of didemnaketal A J. Wulff (JW: travel only)

Canadian Cancer Society Feasibility Grant Assay for the evaluation of small-molecule inhibitors of the PD1/PDL1 interaction in J. Wulff 2009 $35,000 pancreatic cancer

NSERC Discovery Synthesis and evaluation of natural product J. Wulff 2008-2011 $111,150 and designed modulators of protein-protein interactions Merck Frosst Canadian Academic J. Wulff 2008 $20,000 Development Program Award UVic Startup Funds – J. Wulff 2007 $110,000 Personnel & Consumables

8b. Equipment Grants (continued on next page):

grant holders agency equipment year value (indicate PI) C. Bonhe* NSERC Research Tools and rheometry J. Wulff, and 2017 $149,040 Instruments Grant facility 4 others F. Hof* NSERC Research Tools and multichannel J. Wulff, and 2016 $150,000 Instruments Grant platereader 5 others NSERC Research Tools and J. Wulff* Orbitrap MS 2015 $150,000 Instruments Grant and 6 others S. McIndoe* NSERC Research Tools and Cold-EI MS J. Wulff 2014 $150,000 Instruments Grant and 5 others NSERC Research Tools and F. Hof* J. Wulff, LCMS 2012 $145,939 Instruments Grant and 3 others

page 4 of 9 CURRICULUM VITAE (Abbreviated) grant holders agency equipment year value (indicate PI) NSERC Research Tools and HPLC / FPLC J. Wulff 2008 $90,119 Instruments Grant Knowledge general J. Wulff 2008 $150,000* Development Fund Canada Foundation for Innovation general J. Wulff 2008 $150,000* Leaders Opportunity UVic Startup Funds – Equipment general J. Wulff 2007 $75,000**

*Corresponding to 40% of a CFI application package. **Corresponding to 20% of a CFI application package.

8c. Applications Currently Under Review:

applicants agency / award title time period value (indicate PI) Cancer Research Society Operating Grant D. Chithrani* Targeted radiation dose enhancement using 2017-2019 $120,000 PDL1 overexpression in tumour cells J. Wulff

9. PUBLICATIONS and PRESENTATIONS

‡corresponding or presenting author • HQP trained by me are underlined

9a. Peer-Reviewed Publications Accepted or Published (Since 2007 Only):

#40. A. Bains, Y. Cao, S. Kly, J. E. Wulff and M. G. Moffitt‡ (2017) Controlling Structure and Function of Polymeric Drug Delivery Nanoparticles Using Microfluidics. Accepted to Molecular Pharmaceutics, May 18, 2017. #39. L. E. B. Bettio, J. Gil-Mohapel, A. R. Patten, N. F. O’Rourke, R. P. Hanley, K. Gopalakrishnan, J. Wulff and B. R. Christie‡ (2017) Effects of Isx-9 and Stress on Adult Hippocampal Neurogenesis: Experimental Considerations and Future Perspectives. Accepted to Neurogenesis, April 4th 2017. #38. J. Chen, X. Sun, A. G. Oliver and J. E. Wulff‡ (2017) Resolution of Thiele’s Acid. Canadian Journal of Chemistry, 95, 234-238. *Invited contribution. #37. J. Chen and J. E. Wulff‡ (2016) Revisiting the Mechanistic Origins of Thiele’s Ester Dimerization: Probing the Reliability of Predictive Models for Cycloadditions. Organic & Biomolecular Chemistry, 14, 10170-10174. #36. C. Simhadri, M. C. Gignac, C. J. Anderson, N. Milosevich, A. Dheri, N. Prashar, R. T. Flemmer, A. Dev, T. G. Henderson, S. F, Douglas, J. E. Wulff and F. Hof‡ (2016) Structure-Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx . ACS Omega, 1, 541-551. #35. J. Chen, F. P. Burns, M. G. Moffitt and J. E. Wulff‡ (2016) Thermally Crosslinked Functionalized Polydicyclopentadiene with a High Tg and Tunable Surface Energy. ACS Omega, 1, 532-540. *Selected for ACS Virtual Issue: Hot Materials in a Cool Country.” #34. L. E. B. Bettio, A. R. Patten, J. Gil-Mohapel, N. F. O’Rourke, R. P. Hanley, S. Kennedy, K. Gopalakrishnan, A. L. S. Rodrigues, J. Wulff and B. R. Christie‡ (2016) The Small Synthetic Molecule, ISX-9, Can Potentiate Proliferation and Differentiation in the Rat Dentate Gyrus.

page 5 of 9 CURRICULUM VITAE (Abbreviated) Neuroscience, 332, 212-222. #33. A. Bains, J. E. Wulff and M. G. Moffitt‡ (2016) Microfluidic Synthesis of Dye-Loaded Polycaprolactone-block-poly(ethylene oxide) Nanoparticles: Insights into Flow-Directed Loading and In Vitro Release for Drug Delivery. Journal of Colloids and Interface Science, 475, 136-148. #32. R. P. Hanley, S. Horvath, J. An., F. Hof and J. E. Wulff‡ (2016) Salicylates are Interference Compounds in TR-FRET Assays. Bioorganic and Medicinal Chemistry Letters, 26, 973-977. #31. N. Milosevich, M. C. Gignac, J. McFarlane, C. Simhadri, S. Horvath, K. Daze, C. S. Croft, A. Dheri, T. T. H. Quon, S. F. Douglas, J. E. Wulff, I. Paci and F. Hof‡ (2016) Selective inhibition of CBX6—a methyllysine reader protein in the polycomb family. ACS Medicinal Chemistry Letters, 7, 139-144. #30. M. G. Brant and J. E. Wulff‡ (2016) Substituted 3-Sulfolenes: Synthesis and Applications. Synthesis, 48, 1-17. *Invited review paper. *Selected for cover art. #29. J. Chen, B. Kilpatrick, A. G. Oliver and J. E. Wulff‡ (2015) Expansion of Thiele’s Acid Chemistry in Pursuit of a Suite of Conformationally Constrained Scaffolds. Journal of Organic Chemistry, 80, 8979-8989. *Selected as a Featured Article. #28. M. G. Brant, J. Friedmann, C. Bohlkin, A. G. Oliver and J. E. Wulff‡ (2015) Tandem Reactions of Substituted 3-Sulfolenes with Bis-Vinyl Ketones Leading to Highly Functionalized Bicyclic and Tricyclic Frameworks. Organic and Biomolecular Chemistry, 13, 4581-4588. #27. J. A. Davy, B. Moreau, A. G. Oliver and J. E. Wulff‡ (2015) A symmetry-driven approach to the putative spiroketal core of the didemnaketals. Tetrahedron, 71, 2643-2657. #26. R. Stoddard, J. Luo, N. van der Wal, N. F. O’Rourke, J. E. Wulff‡ and S. McIndoe‡. (2014) A multi-pronged mechanistic study of the conjugate addition of alcohols to alkynic esters. New Journal of Chemistry, 38, 5382-5390. #25. M. Richards, M. G. Brant, C. W. Cairo, M. J. Boulanger and J. E. Wulff‡ (2014) Solid- and Solution-State Structural Analyses of Peramivir Reveals a Conformational Dissonance Between Free and Enzyme-Bound States. MedChemComm 5, 1483-1488. *Selected for inside cover art. #24. C. Simhadri, K. D. Daze, S. F. Douglas, T. T. H. Quon, M. Gicnac, A. Dev, F. Peng, M. Heller, M. J. Boulanger, J. E. Wulff and F. Hof‡ (2014) Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7). Journal of Medicinal Chemistry, 57, 2874-2883. #23. N. F. O’Rourke and J. E. Wulff‡ (2014) Investigation of Quantitative Structure-Reactivity Relationships in the Aliphatic Claisen Rearrangement of Bis-Vinyl Ethers Reveals a Dipolar, Dissociative Mechanism. Organic & Biomolecular Chemistry, 12, 1292-1308. #22. S. Tabet, S. F. Douglas, K. D. Daze, G. A. Garnett, K. J. Allen, E. M. Abrioux, T. T. Quon, J. E. Wulff and F. Hof‡ (2013) Synthetic Trimethyllysine Receptors That Bind Histone 3, Trimethyllysine 27 (H3K27me3) and Disrupt its Interaction with the Epigenetic Reader Protein CBX7. Bioorganic and Medicinal Chemistry, 21, 7004-7010. #21. S. S. Y. Wong, M. G. Brant, C. Barr, A. G. Oliver and J. E. Wulff‡ (2013) Dipolar Addition to Cyclic Vinyl Sulfones Leading to Dual Conformation Tricycles. Beilstein Journal of Organic Chemistry, 9, 1419-1425. #20. M. G. Brant and J. E. Wulff‡ (2012) A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors. Organic Letters, 14, 5876−5879. page 6 of 9 CURRICULUM VITAE (Abbreviated) #19. N. F. O’Rourke, K. A. Davies and J. E. Wulff‡ (2012) Mechanistic Studies on an Apparent 6- endo / 5-exo Radical Cascade Across Bis-Vinyl Ether Substrates Reveal a 5-exo / 3-exo / retro-3- exo / 5-exo Cascade. Journal of Organic Chemistry, 77, 8634−8647. #18. J. Bains, J. E. Wulff and M. J. Boulanger‡ (2012) Investigating Terephthalate Biodegradation: Structural Characterization of a Putative Decarboxylating cis-Dihydrodiol Dehydrogenase. Journal of Molecular Biology, 423, 284−293. #17. J. A. Davy, J. M. Mason, B. Moreau and J. E. Wulff‡ (2012) Xanthates as Synthetic Equivalents of Oxyacyl Radicals: Access to Lactones under Tin-Free Conditions. Journal of Organic Chemistry, 77, 6332−6339. #16. J. A. Davy, B. Moreau and J. E. Wulff‡ (2012) Tandem Dihydroxylation / Hemiketalization / Conjugate Addition Leading to a Singly Anomeric Spiroketal. Synthesis, 44, 1854–1862. *Invited contribution to special issue on tandem reactions. #15. C. M. Bromba, J. W. Mason, M. G. Brant, T. Chan, M. Lunke, M. Petric, M. J. Boulanger and J. E. Wulff‡ (2011) The De-guanidinylated Derivative of Peramivir Remains a Potent Inhibitor of Influenza Neuraminidase. Bioorganic and Medicinal Chemistry Letters, 21, 7137–7141. #14. K. A. Davies and J. E. Wulff‡ (2011) Marrying Iterative Synthesis to Cascading Radical Cyclization: 6-endo / 5-exo Radical Cascade Across Bis-Vinyl Ethers. Organic Letters, 13, 5552–5555. #13. A. Hinther, C. M. Bromba, J. E. Wulff and C. C. Helbing‡ (2011) Effects of Triclocarban, Triclosan, and Methyl Triclosan on Thyroid Hormone Action and Stress in Frog and Mammalian Culture Systems. Environmental Science and Technology, 45, 5395–5402. #12. K. A. Davies, K. G. M. Kou and J. E. Wulff‡ (2011) Oxygen-Containing Analogues of Juvenile Hormone III. Tetrahedron Letters, 52, 2302–2305. #11. M. G. Brant, C. M. Bromba, and J. E. Wulff‡ (2010) Tandem Vinylogous 1,2-Addition/Anionic Oxy-Cope Reaction Leading from Butadiene Sulfone to an Orthogonally Functionalized Bicycle. Journal of Organic Chemistry, 75, 6312–6315. *Cited in Organic Highlights, August 22, 2011. #10. K. A. Davies, R. C. Abel and J. E. Wulff‡ (2009) Operationally Simple Copper-Promoted Coupling of Terminal Alkynes with Benzyl Halides. Journal of Organic Chemistry, 74, 3997– 4000. *Cited in Organic Highlights, March 22, 2010. #9. J. E. Wulff, R. Siegrist and A. G. Myers‡ (2007) The Natural Product Avrainvillamide Binds to the Oncoprotein Nucleophosmin. Journal of the American Chemical Society, 129, 14444–14451. #8. J. E. Wulff, S. B. Herzon, R. Siegrist and A. G. Myers‡ (2007) Evidence for the Rapid Conversion of Stephacidin B into the Electrophilic Monomer Avrainvillamide in Cell Culture. Journal of the American Chemical Society, 129, 4898–4899. #7. J. M. Sorbetti, K. N. Clary, D. A. Rankic, J. E. Wulff, M. Parvez and T. G. Back‡ (2007) Aza- Morita-Baylis-Hillman Reactions and Cyclizations of Conjugated Dienes Activated by Sulfone, Ester, and Keto Groups. Journal of Organic Chemistry, 72, 3326–3331.

9b. Selected Non-Peer-Reviewed Publications (Since 2007 Only):

#3. J. Wulff‡ (2015) Young Career Focus Article. Synform, 05, A62-A63. DOI: 10.1055/s-0034- 1380377. #2. C. C. Helbing‡, A. Hinther, J. E. Wulff, C. M. Bromba and N. Veldhoen (2011) Reply to 2nd Comment on “Effects of Triclocarban, Triclosan, and Methyl Triclosan on Thyroid Hormone page 7 of 9 CURRICULUM VITAE (Abbreviated) Action and Stress in Frog and Mammalian Culture Systems”. Environmental Science and Technology, 45, 10285–10287. #1. C. C. Helbing‡, J. E. Wulff, C. M. Bromba, A. Hinther and N. Veldhoen (2011) Reply to Comment on “Effects of Triclocarban, Triclosan, and Methyl Triclosan on Thyroid Hormone Action and Stress in Frog and Mammalian Culture Systems”. Environmental Science and Technology, 45, 7600–7601.

9c. Selected Intellectual Property (Since 2007 Only):

#5. J. E. Wulff‡, J. Chen, M. G. Moffitt, and F. Burns (2016) Functionalized Polydicyclopentadiene. US Provisional Patent Application No. 62/297,567, filed February 19, 2016; US Provisional Patent Application No. 62/347,446, filed June 8, 2016; PCT Application No. PCT/CA2017/050199 filed February 16, 2017. #3. J. E. Wulff‡, M. G. Brant, J. W. Mason, C. M. Bromba and M. J. Boulanger (2010–2012) Synthesis of Bicyclic Compounds and Method for their Use as Therapeutic Agents. US National Filing 13/586,687, filed February 15, 2012; US Patent Appl. 61/591,630, filed January 27, 2012; PCT application PCT/CA2011/000174; WO 2011097717, filed February 14, 2011; US Patent Appl. 61/304,738, filed February 15, 2010. Granted August 5, 2014.

9d. Scientific Invited Lectures (since 2007 only):

2017:  ACS Northwest Regional Meeting (NORM 2017)  Simon Fraser University, Burnaby BC 2016:  Bristol-Myers Squibb, Wallingford, CT  City University of New York, Brooklyn  University of Saskatchewan, Saskatoon, SK 2015:  Gordon Research Conference: Organic Reactions and Processes 2014:  97th Canadian Society for Chemistry Conference, Vancouver, BC  Université de Montréal, Montréal, PQ  McGill University, Montréal, PQ  Université du Québec à Montréal, Montréal, PQ  Université de Sherbrooke, Sherbrooke, PQ 2013:  Western Canadian Undergraduate Chemistry Conference 2012:  York University, Toronto, ON  Université Laval, Quebec City, QC  University of Toronto, Toronto, ON  North Dakota State University, Fargo, ND  University of North Dakota, Grand Forks, ND  University of Manitoba, Winnipeg, MB  Lakehead University, Thunder Bay, ON  University of Regina, Regina, SK  University of Lethbridge, Lethbridge, AB  University of Calgary, Calgary, AB  University of Ottawa, Ottawa, ON  University of BC, Vancouver, BC th 2011:  94 Canadian Society for Chemistry Conference, Montréal, PQ  Department of Chemistry, University of Bath 2010:  Boehringer Ingelheim, Laval, PQ  Camosun College, Victoria, BC  10th Organic Workshop for Leading Young Canadian , Niagara, ON 2008:  Department of Biochemistry and Microbiology, University of Victoria 2007:  Département des Sciences Fondamentales, Université du Québec à Chicoutimi  Department of Biological Chemistry and Molecular Pharmacology, Harvard University

9e. Contributed Presentations at Conferences or Institutions (since 2007 only):

J. Wulff: 47 scientific presentations at conferences and institutions (2007–2016) 20 non-scientific public lectures (2011–2016) Research Group: 19 contributed talks at conferences (2009–2016) 23 contributed posters at conferences (2008–2016) (including 6 award-winning presentations from group members) page 8 of 9 CURRICULUM VITAE (Abbreviated) 10. SERVICE and PROFESSIONAL ACTIVITIES

10a. Selected University and Faculty Committees:

Elected Member, Vice-President Research search committee (2013-2014) Chair, radiation safety committee (2008-2010) Chair, biological safety committee (2014-2016)

10b. Selected Departmental Committees and Responsibilities:

Director, Chemistry for the Medical Sciences BSc Program (2013- ) Director, CAMTEC Biomolecular Sample Preparation Facility (2015- ) Chair, working group on new programs (2011-2013) Chair, curriculum committee (2010-2011)

10c. Conference Organizational Committees:

2014 Symposium on Medicinal Chemistry Included in the 97th meeting of the Canadian Society for Chemistry (joint with Robert Young, Simon Fraser University) 2013 Symposium on Inhibitors of Protein-Protein Interactions Included in the 96th meeting of the Canadian Society for Chemistry 2012 11th Organic Workshop for Leading Young Canadian Chemists, Banff, AB (joint with Michel Gravel, University of Saskatchewan) 2012 Symposium on Small Molecule Drug Design and Development Included in the 95th meeting of the Canadian Society for Chemistry

10d. Grant & Fellowship Committees:

2017 Canadian Institutes for Health Research, Scientific Officer, Pharmacology Panel 2016 Canadian Cancer Society Grants Panel, Innovation & Innovation-to-Impact 2015 Canadian Cancer Society Grants Panel, Innovation & Innovation-to-Impact CIHR Foundation Panel Reviewer (Stage 2) 2012 Canadian Cancer Society Grants Panel, Impact Grants Panel Member 2011 Canadian Cancer Society Grants Panel (Peer Reviewer, Novel Therapeutics Panel) Canadian Cancer Society Grants Panel (Scientific Officer, Panel G1) 2010 Canadian Cancer Society Grants Panel (Scientific Officer, Panel G1) 2009 Michael Smith Foundation, Biomedical (SGS) Evaluation Committee, Senior Trainee Awards Panel. 2008 Michael Smith Foundation, Biomedical (SGS) Evaluation Committee, Senior Trainee Awards Panel.

10e. Other Grant Review Activities:

NSERC: Discovery, CRD & CREATE grants CIHR: Operating grants CCSRI: Operating grants CFI: John R. Evans Leaders fund nominations MITACS: Operating grants Canada Research Chairs: CRC Tier II nominations ACS Petroleum Research Fund: Operating grants Others: Manitoba Medical Service Foundation, Netherlands Organization for Scientific Research, and Cancer Research UK

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