CURRICULUM VITAE (Abbreviated) JEREMY E. WULFF Department of Chemistry, University of Victoria 1. EDUCATION and TRAINING a. Degrees Held degree institution year obtained PhD University of Calgary 2004 BSc (Hons., Co-op) University of Victoria 1999 b. Postdoctoral Experience NSERC Postdoctoral fellow, Harvard University 2005-2007 2. SELECTED POSITIONS HELD PRIOR to APPOINTMENT at UVic period company, job title, duties 1999 : 01-06 Methylgene, research assistant, synthetic organic methodology 1998 : 05-08 Dept. of National Defense, analytical chemist, ICP-MS analysis 1997 : 05-08 Merck Frosst Canada, research assistant, natural product total synthesis 3. ACADEMIC APPOINTMENTS period rank academic unit 07/2007-06/2013 Assistant Professor (renewed 2009) UVic Chemistry 07/2013- Associate Professor with Tenure UVic Chemistry 4. SIGNIFICANT ADMINISTRATIVE or LEADERSHIP ROLES period role 2013- Director, Chemistry for the Medical Sciences BSc Program 2015- Director, CAMTEC Facility for Biomolecular Sample Preparation 5. HONOURS and AWARDS 5a. Recent Awards (since Appointment at UVic): 2012-2022: Canada Research Chair (Tier II) in Bioactive Small Molecule Synthesis [Renewed in 2017] 2011-2019: Michael Smith Foundation for Health Research Career Scholar Award [Renewed in 2016] 2014: Thieme Chemistry Journal Award Top-20-Under-40 on Vancouver Island [Only academic awarded since the re-launch of the program] 2015: Selected for a Synform Young Career Focus Article th [7 researcher worldwide selected for summary] 5b. Earlier Fellowships and Awards: NSERC PDF, John Kendall Thesis Award, I.W. Killam Memorial Scholarship, AHFMR Studentship, NSERC PGSA and PGS-B, Don Tavares Teaching Excellence Award. page 1 of 9 CURRICULUM VITAE (Abbreviated) 6. MAJOR FIELD(S) of SCHOLARLY or PROFESSIONAL INTEREST Organic synthesis, medicinal chemistry, chemical biology, synthetic polymers 7. RESEARCH GROUP 7a. Current Research Group: group member program period supervised primary project CAMTEC Facility for Biomolecular Michael Gignac Research Associate Apr 16 – Sample Preparation (FBS) Manager Block copolymers of functionalized Tyler Cuthbert PDF Mar 17 – polydicyclopentadiene Thiele’s esters and neuraminidase Jun Chen PhD Sept 13 – inhibitors Ronan Hanley** PhD Sept 13 – Small-molecule PD1/PDL1 inhibitors Tong Li PhD Sept 16 – Functionalized polydicyclopentadiene Synthesis of tricyclic sulfones for Andy Un MSc Jan 17 – biological testing Jon Sader MSc Sept 17 – Oxasteroid synthesis Katherine Krause BSc May 17 – Synthesis of MRI1 inhibitors ** Jointly supervised with Prof. Fraser Hof 7b. MSc and PhD Graduates: group member period supervised primary project post-graduate positions Thomas Doerksen, Cytotoxic MTAP Completing a PhD at Guelph University Sept 15 – Aug 16 MSc substrates (Philosophy of Science) Neuraminidase inhibitors Postdoc with Weaver (TWRI), then Mike Brant, PhD May 09 – Jul 15 from bicyclic sulfones Associate Scientist, Zymeworks Jason Davy, Synthesis of the Researcher with Pharmaster labs Sept 08 – Dec 14 PhD didemnaketal core then Gilead Pharma (Edmonton) Natasha O’Rourke, Rearrangements of Postdoc, Micalizio group, Dartmouth Sept 08 – Dec 14 PhD oligovinyl ethers (NH) Katherine Davies, Synthesis and properties Senior Proposal Writer, PRA July 07 – June 12 PhD of oligovinyl ethers International Caleb Bromba, Synthesis of molecular Aug 07 – Aug 12 Organics Analyst, AGAT Labs PhD probes 7c. Other Group Alumni: • 42 past undergraduate students (2007–2017) • 1 past MSc exchange student (2007–2017) • 5 past research associates (2007–2017) 7d. Research Group Fellowships and Awards: (national awards only) Boehringer Ingelheim Cooperative Research Scholarship to Jason Davy, CIHR Master’s Fellowship to Mike Brant, NSERC CGS-M and PGS-D3 to Natasha O’Rourke, NSERC CGS-M to Thomas Doerksen. page 2 of 9 CURRICULUM VITAE (Abbreviated) 8. RESEARCH GRANTS (since UVic appointment) 8a. Research Operating Grants (continued on next page): grant holders value agency / award title time period (indicate PI) (to J. Wulff) NSERC Discovery Grant J. Wulff 2016-2021 $225,000 Total synthesis of unnatural products UVic Canada Research Chair J. Wulff 2012-2022 $100,000 Research Supplement Michael Smith Foundation for Health 2011-2019 J. Wulff $120,000 Research Incentive Award [renewed 2016] UVic MSFHR Career Award J. Wulff 2012-2019 $157,500 Research Supplement M. Moffitt* C. Allen, C. Bohne, NSERC CREATE Grant $1,650,000 Polymer nanoparticles for drug delivery J. Oh, M.-A. Fortin, 2017-2023 ($82,500) (POND) M. Bazalova-Carter, J. Wulff, R. Reilly NSERC Idea to Innovation Grant Functionalized polydicyclopentadiene: J. Wulff 2017-2018 $125,000 reduction to commercially viable practice ACS PRF Grant J. Wulff 2017-2019 US$110,000 Functionalized polydicyclopentadiene UVic Internal Research Seed Grant M. Akbari* A smart drug-delivery implant for management 2017-2018 $10,000 of glioblastoma multiforme J. Wulff NSERC Engage Grant J. Wulff* High-level characterization of the effects of 2016-2017 $25,000 de-icing salts on polymer composite insulator R. Padmawar shed hydrophobicity and monomer leakage CCSRI Innovation Grant Y. Wang* $198,018 Identification of lead compounds of cytotoxic J. Wulff, 2014-2016 MTAP substrates for treatment of MTAP- ($61,500) deficient cancers H. Cheng N. Abraham* CCSRI Innovation Grant $200,000 Therapeutic targeting of the IL-7Ra pathway in J. Wulff 2014-2017 ($45,000) acute lymphoblastic leukemia M. Boulanger Prostate Cancer Canada Movember Grant F. Hof* $200,000 Developing small-molecule antagonists of J. Wulff 2013-2015 chromobox 7 (CBX7) as epigenetic therapies ($50,000) for aggressive prostate cancer M. Cox J. Wulff* CCSRI Innovation Grant F. Hof, J. An Small-molecule inhibitors of the PD1-PDL1 2013-2015 $200,000 interaction for treating metastatic cancer M. Boulanger B. Nelson page 3 of 9 CURRICULUM VITAE (Abbreviated) grant holders value agency / award title time period (indicate PI) (to J. Wulff) Cancer Research Society Operating Grant J. Wulff* C. Cairo Selective inhibitors of human neuraminidase 2012-2014 $120,000 NEU3 as potential therapeutics for castration- M. Boulanger resistant prostate cancer Y. Wang NSERC Discovery Synthesis and evaluation of scaffolds to control J. Wulff 2011-2016 $175,000 protein-protein and protein-DNA interactions Prostate Cancer Canada Pilot Grant F. Hof* $120,000 Small molecule disruptors of J. Wulff, 2011-2013 EZH2/H3K27me3/CBX7 signaling as targeted ($30,000) therapies for highly aggressive prostate cancer P. Howard J. Wulff* $100,000 CIHR Bridge Funding 2010-2012 Treating drug-resistant influenza M. Boulanger ($65,000) Boehringer Ingelheim Cooperative J. Davy* $60,000 Research Award 2010-2013 Synthesis of didemnaketal A J. Wulff (JW: travel only) Canadian Cancer Society Feasibility Grant Assay for the evaluation of small-molecule inhibitors of the PD1/PDL1 interaction in J. Wulff 2009 $35,000 pancreatic cancer NSERC Discovery Synthesis and evaluation of natural product J. Wulff 2008-2011 $111,150 and designed modulators of protein-protein interactions Merck Frosst Canadian Academic J. Wulff 2008 $20,000 Development Program Award UVic Startup Funds – J. Wulff 2007 $110,000 Personnel & Consumables 8b. Equipment Grants (continued on next page): grant holders agency equipment year value (indicate PI) C. Bonhe* NSERC Research Tools and rheometry J. Wulff, and 2017 $149,040 Instruments Grant facility 4 others F. Hof* NSERC Research Tools and multichannel J. Wulff, and 2016 $150,000 Instruments Grant platereader 5 others NSERC Research Tools and J. Wulff* Orbitrap MS 2015 $150,000 Instruments Grant and 6 others S. McIndoe* NSERC Research Tools and Cold-EI MS J. Wulff 2014 $150,000 Instruments Grant and 5 others NSERC Research Tools and F. Hof* J. Wulff, LCMS 2012 $145,939 Instruments Grant and 3 others page 4 of 9 CURRICULUM VITAE (Abbreviated) grant holders agency equipment year value (indicate PI) NSERC Research Tools and HPLC / FPLC J. Wulff 2008 $90,119 Instruments Grant British Columbia Knowledge general J. Wulff 2008 $150,000* Development Fund Canada Foundation for Innovation general J. Wulff 2008 $150,000* Leaders Opportunity UVic Startup Funds – Equipment general J. Wulff 2007 $75,000** *Corresponding to 40% of a CFI application package. **Corresponding to 20% of a CFI application package. 8c. Applications Currently Under Review: applicants agency / award title time period value (indicate PI) Cancer Research Society Operating Grant D. Chithrani* Targeted radiation dose enhancement using 2017-2019 $120,000 PDL1 overexpression in tumour cells J. Wulff 9. PUBLICATIONS and PRESENTATIONS ‡corresponding or presenting author • HQP trained by me are underlined 9a. Peer-Reviewed Publications Accepted or Published (Since 2007 Only): #40. A. Bains, Y. Cao, S. Kly, J. E. Wulff and M. G. Moffitt‡ (2017) Controlling Structure and Function of Polymeric Drug Delivery Nanoparticles Using Microfluidics. Accepted to Molecular Pharmaceutics, May 18, 2017. #39. L. E. B. Bettio, J. Gil-Mohapel, A. R. Patten, N. F. O’Rourke, R. P. Hanley, K. Gopalakrishnan, J. Wulff and B. R. Christie‡ (2017) Effects of Isx-9 and Stress on Adult Hippocampal Neurogenesis: Experimental Considerations and Future Perspectives. Accepted to Neurogenesis, April 4th 2017. #38. J. Chen, X. Sun, A. G. Oliver and J. E. Wulff‡ (2017) Resolution of Thiele’s Acid. Canadian Journal of Chemistry, 95, 234-238. *Invited contribution. #37. J. Chen and J. E. Wulff‡ (2016) Revisiting the Mechanistic Origins of Thiele’s Ester Dimerization: Probing the Reliability