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Home , 40S ribosomal protein S2, 40S ribosomal protein S5, 40S ribosomal protein S7, 40S ribosomal protein S8, 60S ribosomal protein L4, 60S ribosomal protein L6

SUPPLEMENTARY DATA Supplementary Table 3. Abundance of all identified by LC-MS/MS in hearts of tamoxifen injected control (Ctrl) mice and βV59M mice diabetic for 24 hrs or 2 weeks. Each replicate represents a different mouse.

1% FDR, Score>20 Normalized abundance CTRL Tamoxifen 24hrs diabetic 2 weeks diabetic Accession Peptide countUnique peptidesConfidence scorep-value (ANOVA) Replicate 1 Replicate 2 Replicate 3 Replicate 1 Replicate 2 Replicate 3 Replicate 1 Replicate 2 Replicate 3 Description A2ASS6 154 139 7473,23 1,02E-01 296453,16 447183,44 397718,49 379266,63 365737,36 457176,86 333686,27 333337,26 304174,84 Ubiquinol--c complex assembly factor 1 OS=Mus musculus GN=Uqcc1 PE=1 SV=1 E9Q401 120 98 6250,65 3,23E-01 1377755,93 1571097,05 2150633,97 1643845,95 1871112,31 2052156,78 1752079,82 1459926,92 1552653,10 subunit beta type-4 OS=Mus musculus GN=Psmb4 PE=1 SV=1 Q9JHU4 75 68 3952,91 2,40E-01 382430,16 444757,12 322446,00 399790,96 494004,50 505538,53 469213,02 369377,12 413205,23 Glutathione S- theta-1 OS=Mus musculus GN=Gstt1 PE=1 SV=4 P26039 73 60 4591,34 1,99E-01 554345,29 511923,88 273197,00 404628,60 528154,65 1156629,53 761949,17 486911,25 408545,73 Serpin H1 OS=Mus musculus GN=Serpinh1 PE=1 SV=3 Q60597 65 59 5361,86 7,90E-01 27664458,10 27093404,96 18962842,10 19620233,87 23915109,97 24053386,69 23818394,56 18482731,21 21474349,66 -associated RP/EB family member 3 OS=Mus musculus GN=Mapre3 PE=1 SV=1 Q62234 61 58 3528,46 6,03E-03 2956758,73 2820593,54 3387093,89 2538526,80 2609168,11 2389061,17 2666205,59 2416004,47 2116537,29 synthetase OS=Mus musculus GN=Glul PE=1 SV=6 Q99KI0 66 58 5398,99 3,83E-01 207257804,91 240928267,47 214531069,87 198430060,50 220522739,74 190938930,56 209231883,41 214473544,37 216256516,78 Microtubule-associated protein 4 OS=Mus musculus GN=Map4 PE=1 SV=3 P11531 57 54 2779,16 3,62E-02 1309494,84 1478834,88 2051021,92 2456558,79 1611737,41 1470193,61 1251634,19 1277901,57 846156,00 N-alpha- 15, NatA auxiliary subunit OS=Mus musculus GN=Naa15 PE=1 SV=1 Q8BMS1 57 54 4517,52 3,67E-02 64002296,23 63201034,96 55384030,14 63661980,86 76929769,31 67508286,16 69462179,35 76219585,98 89334792,57 -binding protein 1 OS=Mus musculus GN=Hebp1 PE=1 SV=2 Q6PB66 55 52 3019,15 3,16E-01 2547911,82 2799609,95 2633583,83 3149922,98 3067452,49 2332437,55 3013346,18 1415306,34 1914979,91 Apolipoprotein B-100 OS=Mus musculus GN=Apob PE=1 SV=1 P70670;Q60817 52 50 3315,96 9,90E-01 876077,31 1045379,11 1051464,03 793483,67 1066388,07 1132305,76 950044,70 826100,28 994120,37 Probable ATP-dependent RNA DDX56 OS=Mus musculus GN=Ddx56 PE=2 SV=1 P50544 53 49 4284,44 5,72E-02 31766230,02 32092910,90 21435861,90 22712465,54 23343266,60 22910477,34 40123830,42 41615837,14 28730027,69 GTPase IMAP family member 4 OS=Mus musculus GN=Gimap4 PE=1 SV=1 P56480 50 48 4970,95 5,98E-03 324833592,96 338971415,20 300375155,54 341591603,17 330104365,66 340670754,46 368830235,88 338708942,81 355587209,16 28S S36, mitochondrial OS=Mus musculus GN=Mrps36 PE=1 SV=1 O70468 52 48 2993,66 7,79E-01 2020861,97 3294498,58 5379872,34 2750548,45 3573004,27 2736896,51 5726182,32 6846709,13 2281999,00 beta chain OS=Mus musculus GN=Fgb PE=1 SV=1 Q03265 58 48 4643,96 9,45E-01 214977576,74 213005639,33 202444873,75 186466162,74 215628413,72 202030780,60 248352619,38 188002172,18 193906832,34 Hematopoietic progenitor cell antigen CD34 OS=Mus musculus GN=Cd34 PE=1 SV=1 Q8BTM8 52 46 2843,41 3,68E-01 626074,39 422954,77 252373,65 343882,01 365732,85 630194,70 638646,21 318227,19 223980,56 oxidase assembly factor 7 OS=Mus musculus GN=Coa7 PE=1 SV=1 Q99JY0 49 45 3667,18 6,83E-02 80407767,72 87026846,15 66538144,11 56340291,44 65291378,29 57598674,29 85745633,70 99275501,81 76226589,57 Hyccin OS=Mus musculus GN=Fam126a PE=1 SV=2 Q8BWT1 44 44 3625,97 5,99E-01 51795303,16 51348842,68 23886663,15 30131916,86 35801967,03 26174606,21 35002811,04 36496626,81 37141556,05 desulfurase, mitochondrial OS=Mus musculus GN=Nfs1 PE=1 SV=3 P01027 50 43 2727,05 1,76E-01 15087752,10 19073070,47 21342664,17 22007762,98 23901960,50 21379207,54 16095618,85 18993974,53 24504876,93 DnaJ homolog subfamily B member 4 OS=Mus musculus GN=Dnajb4 PE=1 SV=1 Q02566 136 43 9151,11 6,67E-01 2910321,04 3169479,37 3257610,40 1972890,26 4356110,19 2147163,52 2530754,96 2569072,90 2564184,65 Oxidation resistance protein 1 OS=Mus musculus GN=Oxr1 PE=1 SV=3 Q61838 47 42 3019,11 1,89E-01 8736945,12 5315474,75 4843078,24 5541446,92 6260423,84 3023062,91 6357698,03 2543543,72 3159064,55 Hematological and neurological expressed 1 protein OS=Mus musculus GN=Hn1 PE=1 SV=3 P63038 43 42 4058,00 7,96E-01 23484262,94 27702622,95 18513037,61 21753531,79 26621433,57 20662243,55 24473392,07 19131147,01 27756125,85 Thioredoxin OS=Mus musculus GN=Txn PE=1 SV=3 Q64727 45 41 2595,58 1,54E-01 2069253,23 2149274,73 2226043,14 1842910,62 1747104,57 1481255,64 2158036,02 2007443,96 1386663,05 40S ribosomal protein S30 OS=Mus musculus GN=Fau PE=1 SV=1 Q9WUB3 65 41 4232,49 3,05E-01 18144310,22 17934480,70 9495562,56 11411808,95 10838177,40 10243990,49 11895892,92 11501517,18 12323272,31 Neutral alpha-glucosidase AB OS=Mus musculus GN=Ganab PE=1 SV=1 O55143 70 41 5866,73 7,28E-01 222131688,37 34934953,81 25217343,54 32949144,05 29326718,97 21896934,39 2454387409,39 23720199,24 26035777,04 OS=Mus musculus GN=Gss PE=1 SV=1 Q61941 46 40 2978,71 2,55E-01 5815215,91 5803784,25 17018436,88 6292514,93 17737716,35 7738848,59 25126358,03 10862483,50 13991190,58 -sensitive element-binding protein 1 OS=Mus musculus GN=Ybx1 PE=1 SV=3 Q8K2B3 42 40 3418,24 6,87E-01 32948876,18 32649795,70 37233445,91 33397141,98 46035187,56 36207758,08 46527037,38 34228543,67 35354479,26 Complement factor I OS=Mus musculus GN=Cfi PE=1 SV=3 Q8CAQ8 44 38 2834,78 4,79E-02 5500957,24 5717958,04 9772780,32 8103003,79 8944004,96 8452223,00 13004809,92 10119116,63 9251331,04 Serum amyloid P-component OS=Mus musculus GN=Apcs PE=1 SV=2 P54071;Q3TZ89 42 38 3465,41 5,32E-01 110338724,09 121322463,90 118085192,76 90646387,40 126924149,38 94203753,43 105688928,85 75667255,72 126084444,48 Peptidyl-prolyl cis-trans D OS=Mus musculus GN=Ppid PE=1 SV=3 Q7TQ48 41 38 3179,25 7,87E-01 45073132,26 48137752,79 32429469,91 33346346,17 35475389,81 39162206,40 59916073,08 41551275,36 29329753,87 Membralin OS=Mus musculus GN=Tmem259 PE=1 SV=2 P38647 42 38 3480,06 9,69E-01 12411281,53 11027939,77 12267243,97 11733896,79 14639712,46 11160865,70 10176473,89 11828593,56 16125695,39 Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Mus musculus GN=Ppif PE=1 SV=1 P52480;P53657 38 37 3399,87 6,52E-02 21143297,03 25541729,54 25644747,36 22524783,75 21657278,73 19871685,22 22061995,14 15576612,09 21271439,33 Acyl- 2, mitochondrial OS=Mus musculus GN=Acot2 PE=1 SV=2 P07724 39 37 3014,43 8,28E-02 415282053,30 300133623,60 278624865,48 150700550,54 186825431,00 134061950,65 424575775,57 123194254,61 254230911,87 --tRNA , mitochondrial OS=Mus musculus GN=Tars2 PE=1 SV=1 P51174 40 37 2906,46 1,06E-01 97923023,25 94733924,97 70463373,93 72003209,68 80989595,90 66933310,24 101172427,80 100316314,08 91019629,88 Adipocyte plasma membrane-associated protein OS=Mus musculus GN=Apmap PE=1 SV=1 Q921G7 39 36 2628,93 2,12E-01 21763626,04 24570740,13 16640605,07 19237607,08 19851884,43 17546842,81 25114340,35 27415802,02 20505030,60 Guanylate-binding protein 4 OS=Mus musculus GN=Gbp4 PE=1 SV=1 P58281 37 35 1922,64 4,95E-02 1141278,13 1069704,58 1385873,26 1569180,49 1586821,42 1262486,51 1507220,82 1302795,03 1514090,92 Eukaryotic 2 subunit 2 OS=Mus musculus GN=Eif2s2 PE=1 SV=1 P52825 35 35 2272,79 3,16E-01 8639952,66 8286959,83 6474268,64 6105441,74 6012243,85 5733042,05 8779893,89 9993686,99 5161097,08 Bifunctional epoxide 2 OS=Mus musculus GN=Ephx2 PE=1 SV=2 P16546;A2A995 37 35 1927,62 5,53E-01 390330,07 397276,78 313768,63 381528,18 403055,35 413037,57 171196,60 228250,91 485470,27 Acyl-CoA dehydrogenase family member 11 OS=Mus musculus GN=Acad11 PE=1 SV=2 Q91VD9 41 35 2852,15 9,46E-01 8322270,63 7979468,36 9048242,10 7700671,91 8353147,61 8011046,89 10112011,84 6627621,65 6971223,57 Cytochrome P450 4B1 OS=Mus musculus GN=Cyp4b1 PE=1 SV=1 Q9CZU6 35 34 2194,73 4,74E-03 270158863,06 284704293,00 290601524,60 200614366,76 279678104,75 149142483,79 136769782,74 127482706,83 174539205,00 Dehydrogenase/reductase SDR family member 1 OS=Mus musculus GN=Dhrs1 PE=1 SV=1 Q8CC88 36 34 1800,55 2,02E-02 434642,13 311317,33 282642,58 415055,88 925866,39 592729,67 635062,98 739830,41 799408,46 Legumain OS=Mus musculus GN=Lgmn PE=1 SV=1 Q924X2;Q8BGD5 38 34 2233,51 5,02E-01 11917858,75 11551662,62 7896528,10 9053310,80 11530321,08 9565411,66 10512189,57 12110177,75 10365038,04 Ig gamma-2B chain C region OS=Mus musculus GN=Igh-3 PE=1 SV=3 P58252;O08810 36 34 2262,80 9,24E-01 4974076,53 5062927,70 4877346,45 5840446,05 4337232,81 4335143,00 8763821,54 5441624,71 4533245,42 -associated membrane 2 OS=Mus musculus GN=Lamp2 PE=1 SV=2 P09411;P09041 35 33 2557,07 1,29E-01 42871806,53 40624197,09 23488341,26 24099666,61 22144405,46 24966970,29 25998774,37 23538907,83 25174260,67 Chloride intracellular channel protein 5 OS=Mus musculus GN=Clic5 PE=1 SV=1 Q68FD5 33 33 1644,17 1,33E-01 804395,10 802259,78 576786,76 687687,62 535731,26 533380,94 603295,87 440381,82 579667,18 , mitochondrial OS=Mus musculus GN=Cs PE=1 SV=1 Q9JKS4 34 33 2662,23 6,96E-01 24146469,24 27020623,29 24305523,09 25848836,18 26293568,46 28748643,12 26788717,05 25260248,45 26121437,57 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus GN=Mccc2 PE=1 SV=1 P05202 40 33 2606,23 7,66E-01 46443030,46 64590978,19 68566488,95 61864967,24 57700297,62 44566679,87 53769458,50 66640195,71 58427271,87 Putative adenosylhomocysteinase 3 OS=Mus musculus GN=Ahcyl2 PE=1 SV=1 P47934 36 32 2268,79 3,23E-02 12518442,60 15308231,62 10162209,84 10105065,30 14254502,76 10753956,89 16645302,88 17179338,62 14818630,01 subunit gamma-2 OS=Mus musculus GN=Copg2 PE=1 SV=1 Q8CI94 55 32 3749,16 1,08E-01 9010793,59 8033798,56 6013368,09 6913104,50 6815250,58 6800879,67 8302007,36 10445459,78 8164713,87 OS=Mus musculus GN=Fga PE=1 SV=1 P16858;Q64467 32 32 2526,78 1,44E-01 326281116,72 301013216,57 206477331,00 181914586,58 181273070,39 181228818,09 294109600,82 217957433,23 190944206,35 Leukemia inhibitory factor receptor OS=Mus musculus GN=Lifr PE=1 SV=1 P41216 38 32 2700,56 6,35E-01 13900508,28 15496573,26 9066747,23 11919463,04 12052511,45 14184108,14 11251490,59 12449485,03 11167122,34 STE20/SPS1-related proline-alanine-rich protein OS=Mus musculus GN=Stk39 PE=1 SV=1 O08528;Q3TRM8 40 31 2747,70 3,13E-02 1903527,75 1694608,17 2415270,19 2615946,95 2931461,44 2953539,14 2076709,73 2072757,91 2751780,10 Trans-2,3-enoyl-CoA reductase-like OS=Mus musculus GN=Tecrl PE=1 SV=1 Q9EQ20 34 31 2084,59 2,28E-01 13775927,67 16301625,83 9552510,10 9071060,84 7744899,84 9139408,58 12818403,10 8874848,54 9358500,05 ATP synthase subunit beta, mitochondrial OS=Mus musculus GN=Atp5b PE=1 SV=2 Q9Z2I9 34 31 2428,25 4,63E-01 34985110,31 30951760,81 24664177,03 29305446,96 28313882,12 24283408,62 24039910,63 21884220,42 32607708,13 Myomesin-1 OS=Mus musculus GN=Myom1 PE=1 SV=2 Q9DB77 34 31 2279,50 5,64E-01 21017891,64 19840269,66 24827297,12 21785163,95 21179209,60 20589074,63 38065539,35 32768859,14 18729566,67 26S proteasome non-ATPase regulatory subunit 13 OS=Mus musculus GN=Psmd13 PE=1 SV=1 Q921I1 34 30 2246,22 7,50E-02 18316662,84 7458871,89 9258276,04 8219476,85 10261794,31 6599913,09 13672729,34 4952683,60 7181523,38 Acyl carrier protein, mitochondrial OS=Mus musculus GN=Ndufab1 PE=1 SV=1 P97807 33 30 2222,82 6,60E-01 17121461,12 19272496,19 40191078,00 21726439,02 20094914,29 21121326,41 15663177,97 16597973,70 24184981,66 dehydrogenase [NADP(+)] OS=Mus musculus GN=Akr1a1 PE=1 SV=3 Q9D0K2 31 30 2383,90 7,39E-01 21389363,89 26910006,60 20715087,70 29729574,40 20173047,53 19695049,75 23425426,26 23235740,48 21428681,51 Complement factor B OS=Mus musculus GN=Cfb PE=1 SV=2 P05201 36 30 2551,05 9,17E-01 27677776,45 31764038,65 36727096,87 35269335,94 33972762,91 37386494,10 26098580,57 24515230,41 51151351,03 Myoglobin OS=Mus musculus GN=Mb PE=1 SV=3 Q01853 38 29 2260,40 2,60E-01 2713360,45 1909286,77 1808909,67 1758130,54 1967164,59 1676553,89 2680345,07 1292176,70 2454936,41 Peptidyl-prolyl cis-trans isomerase-like 1 OS=Mus musculus GN=Ppil1 PE=1 SV=1 P45952 32 29 2121,93 4,37E-01 33497191,54 38984479,51 35425749,08 38512982,74 39295818,93 31079776,05 30919285,28 53184752,04 40542703,73 Polyribonucleotide 1, mitochondrial OS=Mus musculus GN=Pnpt1 PE=1 SV=1 P08249 30 29 2244,18 6,53E-01 189547718,30 187779589,91 166840163,55 177802504,35 199753024,15 183192631,80 119144463,72 160136449,32 215809274,60 -related protein 1 OS=Mus musculus GN=Akr1b7 PE=1 SV=4 P06745 28 28 2045,74 6,20E-02 17605629,59 22313433,17 14609927,51 11459777,77 10103909,82 12315357,78 16090201,88 15416170,35 11817864,31 Transmembrane protein 109 OS=Mus musculus GN=Tmem109 PE=1 SV=2 Q8VDN2;A7L9Z8 49 28 3213,97 2,81E-01 5212435,38 5229229,33 5415651,43 5347705,71 5626784,53 6820864,11 13362444,07 6809415,38 5801210,30 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 Q8BH59 34 28 2278,58 3,44E-01 4181959,86 2545268,54 2949113,83 3585335,79 4881984,53 3436593,28 7331202,90 3287494,50 4142621,34 NADPH--cytochrome P450 reductase OS=Mus musculus GN=Por PE=1 SV=2 P47857 33 28 2253,35 7,02E-01 4330461,21 4723052,12 5334854,62 4887858,94 5415183,71 5267002,73 3950423,74 5199902,39 5328559,96 Serum amyloid A-1 protein OS=Mus musculus GN=Saa1 PE=1 SV=2 Q2TPA8 31 27 2163,60 5,06E-02 5057367,00 4841432,97 2966386,55 4151703,00 5424799,82 4063919,36 6897692,50 8558559,13 5456726,92 Haptoglobin OS=Mus musculus GN=Hp PE=1 SV=1 Q6P8J7;P30275 29 27 2383,48 3,78E-01 84117417,55 83947077,64 56987173,00 77449826,74 74392108,57 63356993,47 54825036,16 43533505,90 60719400,57 Probable Xaa-Pro 3 OS=Mus musculus GN=Xpnpep3 PE=1 SV=1 P20029 31 27 2114,19 5,03E-01 17569734,44 19002194,22 9511662,34 10421428,08 12488099,28 11004797,87 22657101,16 15909607,71 9943546,82 Dimethylaniline monooxygenase [N-oxide-forming] 2 OS=Mus musculus GN=Fmo2 PE=1 SV=3 Q9CZ13 30 27 2553,28 7,91E-01 45865516,54 43002764,84 62335009,36 50829738,25 41555716,57 39489404,21 74550818,12 59208555,21 33902699,23 Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2 P07310 35 27 2397,14 9,19E-01 128183423,54 121016693,15 159955317,37 127865370,85 146081429,71 136052736,63 122454440,33 111217448,07 164189832,40 Non-specific lipid-transfer protein OS=Mus musculus GN=Scp2 PE=1 SV=3 P17563;Q63836 26 26 1785,35 9,17E-03 4020923,27 3685854,86 3698760,77 3080659,30 2678170,99 3107720,81 5209145,68 4055211,67 4459774,56 Catechol O-methyltransferase OS=Mus musculus GN=Comt PE=1 SV=2 Q61316 31 26 1826,33 1,43E-02 855765,68 843290,34 1004712,61 1040296,18 1121955,45 1105845,20 725348,69 752773,37 998447,27 Protein fantom OS=Mus musculus GN=Rpgrip1l PE=1 SV=2 Q8QZT1 30 26 2537,10 6,71E-02 20671332,74 28443373,32 26834951,87 30052825,43 31954349,41 23447813,86 28829956,19 28776211,18 33998533,75 Trafficking protein particle complex subunit 3 OS=Mus musculus GN=Trappc3 PE=1 SV=1 P05064 36 26 2880,66 1,92E-01 107402426,61 102736670,62 72403513,05 68192393,76 66624927,54 71267126,33 90952873,85 73023028,88 81980570,28 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 Q91YT0 28 26 1921,70 6,38E-01 7002020,04 8427730,38 9111082,51 7553539,79 8011346,45 6266600,90 9156528,01 6801668,77 6750001,26 Selenium-binding protein 1 OS=Mus musculus GN=Selenbp1 PE=1 SV=2 P04247 26 25 2706,26 6,38E-03 953003582,52 970680645,86 1012510175,54 926898297,35 632937490,05 625809260,63 567782020,69 532175913,79 623901644,03 OS=Mus musculus GN=Pdxk PE=1 SV=1 Q8VHX6 34 25 1924,87 3,37E-02 362444,84 474857,67 390359,13 407807,51 555246,26 415100,65 511671,43 395122,82 436311,31 Lon homolog, mitochondrial OS=Mus musculus GN=Lonp1 PE=1 SV=2 O88492 27 25 2095,64 4,65E-02 1302795,85 1616771,53 1420191,34 1900658,99 1474953,68 1562075,95 988692,05 1454492,06 1425015,82 Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus musculus GN=Hmgcs2 PE=1 SV=2 Q8K1M6 27 25 1413,73 9,63E-02 629146,94 958870,38 749040,88 1381132,26 926971,24 1166849,68 650163,27 768748,91 1054864,39 [NAD] subunit gamma 1, mitochondrial OS=Mus musculus GN=Idh3g PE=1 SV=1 Q02053 31 25 1890,28 1,13E-01 2242005,66 2716378,26 2325113,42 2108859,54 2271753,04 2011710,20 1492067,61 1500427,31 2775323,03 carboxyl-terminal hydrolase 47 OS=Mus musculus GN=Usp47 PE=1 SV=2 Q8BFR5 26 25 1880,65 1,34E-01 5627790,63 5725192,85 3983211,27 6325667,39 7518973,01 5839623,01 5242673,28 4988498,47 6381277,60 Ceruloplasmin OS=Mus musculus GN=Cp PE=1 SV=2 P28665 50 25 2608,19 3,02E-01 10144242,33 2625651,18 2997037,48 6643270,49 5091903,95 2147969,37 3982096,45 1382080,04 2462014,13 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Mus musculus GN=Aimp1 PE=1 SV=2 P35486 31 25 1943,96 9,01E-01 11572755,48 15374381,15 13620221,75 12787012,48 16671830,90 10514249,76 16843269,66 14360991,60 12810264,98 Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 OS=Mus musculus GN=Gpihbp1 PE=1 SV=1 O08749 26 25 1988,31 9,03E-01 24494377,62 26425707,24 19051015,08 21121417,07 24289592,08 23286268,71 28283951,93 18434087,03 22593828,11 Isoleucine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Iars PE=1 SV=2 Q91ZA3 30 25 1714,45 9,13E-01 1696938,45 2206585,93 2072280,01 1855468,97 1985372,73 1825654,18 1987706,01 1485479,48 2461586,52 Immunoglobulin superfamily member 10 OS=Mus musculus GN=Igsf10 PE=2 SV=2 Q9D0F9 32 25 2146,42 9,19E-01 6127744,37 5515912,91 6025612,46 6210163,45 5743846,18 5225744,30 5419052,24 6034715,46 6275213,39 Mitochondrial coenzyme A transporter SLC25A42 OS=Mus musculus GN=Slc25a42 PE=1 SV=1 Q99LC3 26 25 1769,64 9,69E-01 4759972,05 4943252,38 6806277,96 5525123,10 7238008,59 4693152,87 6796442,63 6573339,68 4302185,95 Xaa-Pro aminopeptidase 1 OS=Mus musculus GN=Xpnpep1 PE=1 SV=1 P34914 24 24 1628,96 4,04E-03 3581863,30 3612233,24 3601999,79 3899206,40 4088709,18 3808555,66 4198285,14 4665774,68 5347354,12 Importin subunit beta-1 OS=Mus musculus GN=Kpnb1 PE=1 SV=2 P63017 36 24 2532,70 1,67E-01 14037330,81 11911123,47 9539523,22 9475838,61 8426691,60 10268908,87 10496606,65 7171804,55 10316671,15 EH domain-containing protein 4 OS=Mus musculus GN=Ehd4 PE=1 SV=1 Q0II04 27 24 1272,57 8,22E-01 2326579,92 2386594,10 3815365,06 2429424,08 3725694,81 2525108,21 2499158,06 2317537,13 3260273,57 OS=Mus musculus GN=Fgg PE=1 SV=1 P16125 29 23 2270,54 7,60E-02 54659898,05 54491072,04 44181209,52 41344391,72 47281846,45 33335050,56 35349587,88 34117939,16 45784015,52 /threonine-protein 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 Q91WD5 25 23 1612,13 1,50E-01 10621183,80 9400795,28 8611987,54 6395842,09 6155511,03 7095345,93 12319227,62 10188151,69 5013600,98 Phosphomannomutase 2 OS=Mus musculus GN=Pmm2 PE=1 SV=1 Q11011 24 23 1386,81 1,65E-01 769568,73 613529,64 863825,00 841419,19 887998,73 797452,70 687236,69 477498,49 842223,67 39S ribosomal protein L11, mitochondrial OS=Mus musculus GN=Mrpl11 PE=1 SV=1 Q8BH64 29 23 1460,41 1,70E-01 2492164,00 1994078,06 2650244,77 2306240,96 2441767,50 2199275,67 2045121,88 1810670,02 2377837,62 1 regulatory subunit 7 OS=Mus musculus GN=Ppp1r7 PE=1 SV=2 P04919 24 23 1236,83 3,39E-01 10479768,99 8664098,89 1079506,46 1086933,98 1183536,35 544016,86 10446310,57 1537772,64 866593,27 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Mus musculus GN=Mccc1 PE=1 SV=2

©2018 American Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P26041 38 23 1947,30 4,34E-01 1146613,45 1161589,34 1363106,45 1333279,64 1141451,38 1225243,05 1214886,26 1323677,09 1161411,84 -13 OS=Mus musculus GN=Cdh13 PE=1 SV=2 P17710 31 23 1849,71 8,56E-01 1112057,81 1235674,49 1519181,80 1409234,42 1207684,64 1189100,67 1428376,80 1657892,81 1178493,35 Serum amyloid A-2 protein OS=Mus musculus GN=Saa2 PE=1 SV=1 Q62261 26 23 1194,82 9,85E-01 174087,48 240909,79 262681,39 208286,45 226194,55 254008,48 189693,71 205940,72 230453,86 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 P27546 23 22 1420,87 6,02E-04 1578988,66 1640364,06 1431460,13 1346592,58 1397306,88 1290128,63 1334423,95 1236296,15 1241859,88 Coronin-1C OS=Mus musculus GN=Coro1c PE=1 SV=2 Q9EQP2 26 22 1702,76 1,11E-02 1992764,69 1716632,20 1816922,87 1670876,40 1871262,04 1797203,96 2482745,40 1828752,46 2524046,38 High mobility group protein B1 OS=Mus musculus GN=Hmgb1 PE=1 SV=2 A6X935 23 22 1170,63 1,22E-02 475586,61 514553,35 214917,95 1333517,51 1644876,28 1431999,15 710559,24 724868,26 319156,43 1-acylglycerol-3-phosphate O- ABHD5 OS=Mus musculus GN=Abhd5 PE=1 SV=1 Q8QZS1 22 22 1339,99 2,14E-02 4657390,93 7636038,64 4124145,39 3605856,37 2100549,88 3362491,43 3243575,40 3336244,36 2414177,78 Mitogen-activated 10 OS=Mus musculus GN=Mapk10 PE=1 SV=2 P21550 33 22 2534,60 2,73E-02 69686999,33 66412884,65 54636046,85 48443029,64 46041109,41 45190610,31 51394808,47 42645550,64 39857536,90 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Mus musculus GN=Itih3 PE=1 SV=3 Q99NB1 23 22 1410,86 1,37E-01 6734783,64 6804505,03 6169924,86 5942919,18 5665981,64 5535933,07 6243255,74 8026477,62 8223592,08 Ragulator complex protein LAMTOR5 OS=Mus musculus GN=Lamtor5 PE=1 SV=1 Q99LC5 23 22 1945,49 1,43E-01 72616858,89 79062939,78 62097486,70 70021257,24 48319521,60 88093350,24 89227145,40 71407716,83 89539344,06 Heat shock protein beta-7 OS=Mus musculus GN=Hspb7 PE=1 SV=3 P06151;P00342 24 22 1600,32 2,30E-01 26172243,78 26827556,19 29006982,53 24826429,89 20772158,36 23939862,18 26304405,29 27896729,24 25824173,94 -related protein 2/3 complex subunit 1B OS=Mus musculus GN=Arpc1b PE=1 SV=4 P08113 26 22 1559,19 2,54E-01 1120112,00 970651,18 980067,55 1053665,46 958731,48 1191968,00 948944,42 810595,28 1166917,28 Serpin B6 OS=Mus musculus GN=Serpinb6 PE=1 SV=1 Q8CHT0 23 22 1421,46 3,04E-01 2239064,41 1996424,57 2940695,11 2449711,33 1847455,33 1341255,85 2112297,65 2053917,02 2209358,99 MAP7 domain-containing protein 1 OS=Mus musculus GN=Map7d1 PE=1 SV=1 P35441 22 22 1177,34 3,30E-01 597658,84 341182,66 185335,45 164829,47 332338,38 705219,19 448775,99 466678,49 138541,87 Kinectin OS=Mus musculus GN=Ktn1 PE=1 SV=1 P14152 23 22 1718,07 4,95E-01 93300532,21 99479630,06 95842647,43 104959654,22 91949038,68 103117086,81 68446231,03 71565079,63 124921346,26 A1 OS=Mus musculus GN=Anxa1 PE=1 SV=2 P24270 24 22 1398,86 5,69E-01 2945252,66 2736340,68 692579,51 1376874,28 1222201,66 1380711,67 3435513,86 1796519,92 1929531,94 Proteasome subunit alpha type-1 OS=Mus musculus GN=Psma1 PE=1 SV=1 O70433 25 22 1513,94 7,36E-01 5773337,45 4724536,73 7894144,12 3848210,65 5439780,43 5792277,86 4870672,50 6202242,07 5406335,71 ATP synthase F(0) complex subunit B1, mitochondrial OS=Mus musculus GN=Atp5f1 PE=1 SV=1 Q07417 22 22 1368,25 7,64E-01 18185960,20 16825687,60 15722806,64 13770082,52 17490537,02 15052554,28 15960931,45 19057476,28 16224312,55 Netrin-G2 OS=Mus musculus GN=Ntng2 PE=1 SV=2 Q8BMF4 22 22 1467,65 8,02E-01 15225322,16 15531221,50 14095246,59 11458837,21 15451759,52 11870722,61 19209766,11 10781045,95 12095502,81 ATP synthase subunit epsilon, mitochondrial OS=Mus musculus GN=Atp5e PE=1 SV=2 Q05793 22 22 1047,62 9,44E-01 408522,39 436412,00 746557,28 482095,77 585650,13 515785,93 549012,84 522206,90 459724,40 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 Q9QXX4 27 21 1714,84 1,90E-02 1014953,12 904111,76 1609806,61 1936302,18 2554954,04 2323326,22 1947993,40 1586160,24 1861360,09 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Mus musculus GN=Ech1 PE=1 SV=1 Q9CQA3 25 21 1599,85 6,89E-02 22484563,46 24436449,93 23094534,27 25596126,42 27514490,64 27613377,04 28135604,11 29304788,78 23650910,64 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 Q9D2G2 22 21 1398,19 2,58E-01 14525745,80 13962969,28 13615496,30 15940036,24 17753373,43 14828209,17 13646481,84 12790121,57 16536882,86 LIM and senescent cell antigen-like-containing domain protein 2 OS=Mus musculus GN=Lims2 PE=1 SV=1 P26443 22 21 1414,70 3,84E-01 3184841,81 2991041,90 2513442,84 2779649,20 3238452,22 2669643,72 2872260,11 3022314,80 3152635,55 Acyl-coenzyme A thioesterase 1 OS=Mus musculus GN=Acot1 PE=1 SV=1 Q9Z0X1 24 21 1528,23 4,63E-01 3475368,06 3344954,40 3662313,07 3216931,05 3870570,25 3575376,30 4663469,99 4534662,03 3874365,63 Protein -isomerase OS=Mus musculus GN=P4hb PE=1 SV=2 Q61425;P15247 25 21 1928,73 6,22E-01 18526701,35 16384964,94 26400073,04 25457281,22 26066754,37 15243464,34 23030985,82 12851525,49 31195337,61 Epimerase family protein SDR39U1 OS=Mus musculus GN=Sdr39u1 PE=1 SV=1 Q00623 25 21 1306,45 7,26E-01 45447520,06 8168642,27 5526929,99 12606482,00 8060142,25 4612367,05 22253866,99 6384758,17 8344164,04 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Mus musculus GN=Bnip3 PE=1 SV=1 Q9DC69 21 21 1354,43 7,39E-01 6821501,25 6470272,94 10663813,47 8813092,64 9371097,61 9324606,28 8948617,84 9506009,98 7043861,15 Optic atrophy 3 protein homolog OS=Mus musculus GN=Opa3 PE=1 SV=1 Q8CGK3 21 20 1014,45 9,39E-03 1791961,24 1709704,81 1840673,38 1856716,64 2071948,22 1751381,21 1612038,61 1790873,37 2020451,65 Peroxisomal 2 OS=Mus musculus GN=Pxmp2 PE=1 SV=2 Q61147 20 20 1085,29 9,57E-03 1223941,12 646384,36 653467,21 1103275,58 1108731,78 744943,91 694802,88 599862,54 613879,94 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Mus musculus GN=Ndufa8 PE=1 SV=3 Q8BH95 20 20 1201,09 1,29E-01 27319398,44 29810467,01 22148482,95 22072599,88 21820534,19 21202636,74 18190634,17 17854399,19 24260581,81 ERO1-like protein alpha OS=Mus musculus GN=Ero1a PE=1 SV=2 Q9JI91;O88990 31 20 1857,36 2,59E-01 972830,33 882484,69 1133949,59 810468,32 940476,57 1083034,39 606377,33 732453,00 564215,32 Transmembrane protein 65 OS=Mus musculus GN=Tmem65 PE=1 SV=1 P47738 24 20 1503,21 2,98E-01 9108364,60 9685435,05 7539903,09 6785105,37 7576238,68 7732288,27 8959950,45 6854175,06 6793375,54 diphosphate-linked moiety X motif 13 OS=Mus musculus GN=Nudt13 PE=1 SV=2 Q9DB20 20 20 1588,23 6,45E-01 73951963,85 68364362,19 61524713,82 60168546,05 65198726,06 63058636,26 83283942,15 77211689,12 57929828,94 Peroxisomal acyl-coenzyme A oxidase 1 OS=Mus musculus GN=Acox1 PE=1 SV=5 Q8VEM8 24 20 1614,62 6,47E-01 67771208,09 77951821,02 62564749,09 56516688,95 66764783,19 55723060,98 84510491,81 61814058,85 60303312,86 -binding protein 1 OS=Mus musculus GN=Rrbp1 PE=1 SV=2 Q8JZQ2;Q920A7 23 20 1449,15 8,12E-01 2513910,15 2439731,56 2519324,83 2461089,92 2549317,69 1873796,67 1834614,45 2610163,12 2309412,69 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Mus musculus GN=Dad1 PE=1 SV=3 Q9JHI5 23 20 1529,28 9,08E-01 7085389,18 9138632,53 11773767,21 7491685,24 8599864,85 8899299,97 8652861,91 8908840,57 8119592,74 Opioid growth factor receptor OS=Mus musculus GN=Ogfr PE=1 SV=1 Q99MR8 22 19 1256,77 1,19E-02 484361,95 657863,82 332165,14 381843,87 823699,79 686353,01 807580,00 880212,23 673303,22 Protein canopy homolog 2 OS=Mus musculus GN=Cnpy2 PE=1 SV=1 Q9JJW5 20 19 1292,38 6,00E-02 10618379,68 11618935,96 10021570,93 11569986,93 11870052,08 12377608,91 9961687,28 9654834,35 9778259,23 Ubiquitin-conjugating E2 K OS=Mus musculus GN=Ube2k PE=1 SV=3 P42125 19 19 1501,41 3,47E-01 32501570,12 38993682,97 32233590,29 27618017,80 34659268,36 24567638,33 29298082,09 34589423,04 40998266,66 ATPase Asna1 OS=Mus musculus GN=Asna1 PE=1 SV=2 P02088 28 19 3051,20 3,65E-01 7371898593,57 8181683332,00 1530829902,00 1839563270,15 1716335967,92 1406316734,78 9959670576,97 2282568245,22 1605449714,61 -regulatory protein FAM213A OS=Mus musculus GN=Fam213a PE=1 SV=2 Q9CQ62 21 19 1431,90 5,89E-01 27344737,41 22231443,57 21103266,42 21422216,26 23198078,19 19741725,65 16345906,34 23241761,53 29106071,55 Calcyclin-binding protein OS=Mus musculus GN=Cacybp PE=1 SV=1 P28650 21 19 1157,06 6,15E-01 1117886,82 1017177,70 1256224,43 1257797,55 1293845,31 1509582,09 674996,51 884434,61 1697434,04 finger protein 394 OS=Mus musculus GN=Znf394 PE=2 SV=3 Q8K0E8;Q9JJ59 20 18 1155,48 8,93E-04 1761997,14 615607,41 875903,14 3996935,70 5462135,32 3437984,64 746436,50 1423145,40 940170,91 B OS=Mus musculus GN=Ctsb PE=1 SV=2 Q8BKC5;Q8BIV3 20 18 1119,29 8,89E-03 616030,17 701688,65 591159,90 607844,31 688723,10 722025,83 760508,47 516396,36 727491,31 Carboxylesterase 1D OS=Mus musculus GN=Ces1d PE=1 SV=1 Q9CQQ7 20 18 1283,10 1,36E-02 22645664,09 24198625,97 26188020,74 29910425,62 26533285,93 24159268,64 23197025,54 25873732,81 22843174,46 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Mus musculus GN=Coq5 PE=1 SV=2 P11404 19 18 1634,94 7,01E-02 322197560,44 362272868,77 278777858,54 288099964,81 262038373,71 261076663,57 384695857,75 562114209,83 323210103,59 -binding mitochondrial carrier protein Aralar2 OS=Mus musculus GN=Slc25a13 PE=1 SV=1 Q62407 21 18 944,30 7,39E-02 187053,47 248176,20 189216,05 276011,29 185883,54 211914,03 168203,12 191887,61 183624,28 Proteolipid protein 2 OS=Mus musculus GN=Plp2 PE=1 SV=1 P11499 36 18 2333,32 1,64E-01 7654704,80 6935556,18 5900504,43 6285387,89 4801071,48 5855185,90 6018337,96 5493853,97 6219110,46 Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Mus musculus GN=Ptcd3 PE=1 SV=2 Q9D6R2 20 18 1695,07 1,91E-01 47260302,49 48754722,30 30397956,69 33526542,84 28943096,51 26850148,15 32399488,69 32558734,10 35951677,84 Cleft lip and palate transmembrane protein 1 homolog OS=Mus musculus GN=Clptm1 PE=1 SV=1 Q9DBG5 18 18 1132,41 3,60E-01 1021845,21 1228589,28 1107543,06 1532677,06 1627463,76 1554006,07 861760,47 1266768,27 1593483,93 Ubiquitin carboxyl-terminal hydrolase 36 OS=Mus musculus GN=Usp36 PE=1 SV=1 Q02357 18 18 977,72 3,71E-01 603618,33 566490,75 106445,44 100157,31 123918,68 78389,26 958817,87 149027,05 108930,71 initiation factor 3 subunit M OS=Mus musculus GN=Eif3m PE=1 SV=1 Q9Z2I0 21 18 1181,69 6,58E-01 947950,04 950935,82 659662,82 954159,76 910067,35 1079971,83 613231,68 474960,31 1022195,64 Flotillin-2 OS=Mus musculus GN=Flot2 PE=1 SV=2 Q63918 18 18 1222,32 7,48E-01 1801526,99 2390622,59 2078084,86 1949338,49 2105321,79 2119017,68 2439327,64 2552407,10 2181632,27 Complement C4-B OS=Mus musculus GN=C4b PE=1 SV=3 O35459 18 17 1586,23 1,43E-02 22978992,51 21660253,55 18630058,69 20769820,84 19996407,60 25240796,80 24640958,76 32471563,34 30909778,72 Echinoderm microtubule-associated protein-like 1 OS=Mus musculus GN=Eml1 PE=1 SV=1 O09161 22 17 1383,45 5,57E-02 13929038,83 15599404,83 14577784,93 17170513,13 18040166,77 21022325,64 14492431,10 14810271,56 16283915,46 Peroxisomal coenzyme A diphosphatase NUDT7 OS=Mus musculus GN=Nudt7 PE=1 SV=2 P48962 36 17 2848,37 1,65E-01 227179303,12 224744751,20 204577122,47 192111700,01 224377669,97 224841660,49 323287044,55 259919597,50 219725176,93 A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=1 SV=2 Q9QYG0 18 17 1221,44 2,06E-01 8881116,94 9117945,15 17373010,75 18027324,60 11244209,18 19005120,52 14456376,59 12130999,57 19100266,94 F-actin-capping alpha-2 OS=Mus musculus GN=Capza2 PE=1 SV=3 Q60932 20 17 1915,16 2,11E-01 12973617,27 10553923,40 12736790,12 8538013,00 10482269,16 9349328,94 27680447,47 22329817,32 9364270,15 -binding protein G(s) subunit alpha isoforms XLas OS=Mus musculus GN=Gnas PE=1 SV=1 Q99MN9 20 17 1478,31 2,21E-01 2421594,84 1830007,95 2083861,09 2329192,35 2141695,25 2415249,36 3149611,08 1843457,66 2609924,86 Acyl-CoA synthetase family member 2, mitochondrial OS=Mus musculus GN=Acsf2 PE=1 SV=1 P27773 20 17 979,75 2,28E-01 775657,59 893315,55 1199703,01 1151329,25 1074527,40 1433075,80 960471,26 1130243,93 1453418,18 Eukaryotic translation initiation factor 4B OS=Mus musculus GN=Eif4b PE=1 SV=1 P06728 22 17 1184,58 2,39E-01 6126234,20 6355544,51 5656621,09 5046724,91 5446042,36 4990165,79 9999008,87 7409477,75 5493131,39 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Mus musculus GN=Hibch PE=1 SV=1 Q91X72 20 17 1252,45 2,53E-01 9837527,96 8421843,53 7499756,56 7906604,91 9956669,80 7482131,63 12147785,15 12198557,41 3796530,42 Peroxisomal multifunctional enzyme type 2 OS=Mus musculus GN=Hsd17b4 PE=1 SV=3 P17751 19 17 1742,52 3,11E-01 48223985,01 47869192,34 37351115,57 42099880,19 51392870,45 40508372,89 38852111,83 32276961,97 54845473,93 N subunit 2 OS=Mus musculus GN=Cpn2 PE=1 SV=2 Q9CWJ9 18 17 781,01 3,33E-01 634399,25 683500,19 443827,50 465487,48 426533,15 547942,02 679004,21 379927,38 692606,78 MICOS complex subunit MIC13 OS=Mus musculus GN=Mic13 PE=1 SV=1 Q9CQN1 19 17 1225,01 4,95E-01 1325561,36 1267270,16 1012427,09 1271853,57 1065472,28 1195959,97 1432667,55 958134,99 1196173,01 Alanine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Aars PE=1 SV=1 Q60936 18 17 1115,22 5,15E-01 5217724,77 5467433,78 3119641,50 3816764,33 3937679,74 3286170,90 4147349,32 3983472,20 4906550,80 Atlastin-2 OS=Mus musculus GN=Atl2 PE=1 SV=1 Q8BMF3;Q8BH75 20 17 1000,39 5,31E-01 1698527,90 1934258,66 2503246,99 2299284,47 2871842,49 1914486,57 1828586,75 1791958,76 2240058,95 --tRNA ligase, cytoplasmic OS=Mus musculus GN=Rars PE=1 SV=2 P17182 26 17 1936,44 6,34E-01 10382168,98 4485233,23 4279182,82 5146540,05 3470520,04 4594849,20 7685009,16 2995219,53 5371734,93 Cysteine and -rich domain-containing protein 1 OS=Mus musculus GN=Chordc1 PE=1 SV=1 P70404 16 16 1346,61 9,49E-03 20166096,48 15812715,85 14691231,99 13857383,12 13067731,58 11349257,53 14034962,06 13223541,38 13877009,62 OS=Mus musculus GN=Dstn PE=1 SV=3 Q9R0H0 17 16 937,21 1,66E-02 369009,47 256487,06 200150,96 525226,70 384707,63 527522,72 412848,78 1333398,78 868359,10 Heat shock protein 105 kDa OS=Mus musculus GN=Hsph1 PE=1 SV=2 Q8CGC7 16 16 888,11 2,59E-02 140336,25 170061,77 162739,85 211995,76 395602,57 261434,77 227787,11 164725,29 215676,36 [ (acetyl-transferring)] kinase 4, mitochondrial OS=Mus musculus GN=Pdk4 PE=1 SV=1 Q922J3 19 16 976,99 8,26E-02 152565,68 140972,65 172123,67 147079,98 167011,77 105484,08 280241,87 239599,89 143945,06 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 Q60864 16 16 759,29 1,19E-01 1724068,31 1473900,54 961020,09 831068,31 833917,74 894811,52 1207682,72 812905,40 860504,31 40S ribosomal protein S12 OS=Mus musculus GN=Rps12 PE=1 SV=2 Q9WVK4;Q3UX62 28 16 1422,92 1,20E-01 1488508,24 1593740,40 1241424,71 1902182,38 2612018,10 2544867,23 1495479,21 977702,41 2256182,22 Vitronectin OS=Mus musculus GN=Vtn PE=1 SV=2 Q9R0Y5 18 16 1337,31 1,35E-01 57040675,92 64711249,17 29058646,75 28615205,62 33303065,95 24310248,88 32539493,42 25326287,29 26599130,02 ER membrane subunit 2 OS=Mus musculus GN=Emc2 PE=1 SV=1 O88342 17 16 1001,81 1,78E-01 1531587,20 1352358,86 1438471,45 1390534,14 1463333,62 1205270,42 1754633,64 1862739,16 1379662,06 Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Mus musculus GN=St6gal1 PE=1 SV=2 P50136 19 16 1051,66 2,24E-01 1467454,32 1764764,94 1229648,10 1547301,41 1858438,06 1802108,60 1539366,86 1304949,52 1607396,75 COP9 signalosome complex subunit 8 OS=Mus musculus GN=Cops8 PE=1 SV=1 Q9DCW4 19 16 1775,96 2,39E-01 84239857,14 91151145,45 66386310,07 73063371,35 75139229,72 62150435,23 84685496,24 78864620,89 89446002,05 Thioredoxin-dependent peroxide reductase, mitochondrial OS=Mus musculus GN=Prdx3 PE=1 SV=1 Q8BH86 17 16 901,74 2,41E-01 411583,55 461659,02 631600,00 871808,35 654527,86 879355,59 573175,86 424034,06 971459,55 Mitochondrial pyruvate carrier 2 OS=Mus musculus GN=Mpc2 PE=1 SV=1 Q99L13 17 16 1461,90 3,38E-01 5720876,87 5502000,53 3160783,23 4954465,25 3437785,40 3606916,30 5409351,98 5235599,82 5368195,34 Mitochondrial inner membrane protein COX18 OS=Mus musculus GN=Cox18 PE=1 SV=5 P28271 18 16 744,71 3,55E-01 588456,62 676909,44 629269,58 975901,66 789279,68 713471,74 410284,47 531647,62 831711,48 DnaJ homolog subfamily A member 4 OS=Mus musculus GN=Dnaja4 PE=1 SV=1 Q9ET78 18 16 966,32 3,58E-01 1030303,90 1234622,71 787913,83 874532,18 770760,85 776828,38 858591,89 823089,08 768269,85 Isoamyl acetate-hydrolyzing 1 homolog OS=Mus musculus GN=Iah1 PE=1 SV=1 Q8BIJ6 20 16 967,12 4,45E-01 1080284,78 1053826,61 1008068,13 1173001,18 1181990,02 1104711,18 1172712,12 680686,11 1085043,75 Acetyl-CoA acetyltransferase, cytosolic OS=Mus musculus GN=Acat2 PE=1 SV=2 P09542 21 16 1610,15 4,86E-01 5831735,62 7740160,15 10667580,55 8626017,50 13898686,22 10265189,78 6326407,83 8112580,77 6679941,43 Receptor expression-enhancing protein 5 OS=Mus musculus GN=Reep5 PE=1 SV=1 O54724 16 16 1148,45 5,14E-01 9049842,44 9217990,01 7778428,25 6725624,21 6706987,28 7574225,29 10470371,88 7416330,03 7153278,54 Complex III assembly factor LYRM7 OS=Mus musculus GN=Lyrm7 PE=3 SV=2 Q9JK42;Q922H2 17 16 904,78 5,88E-01 1622430,03 1977910,42 2302397,89 1516554,39 2094839,56 1857075,10 1883014,68 2996286,11 1870906,87 Alanine aminotransferase 1 OS=Mus musculus GN=Gpt PE=1 SV=3 Q91VM9 16 16 895,56 6,55E-01 1855081,11 2355029,85 2687926,41 2589500,45 2728262,31 2344715,74 2019385,20 2516295,11 3764331,55 Mimitin, mitochondrial OS=Mus musculus GN=Ndufaf2 PE=1 SV=1 Q80XN0 19 16 1269,00 7,29E-01 9306717,24 9266436,37 5074388,65 8477585,79 8917624,66 9100255,59 10449219,34 5777220,37 8831642,59 Bifunctional glutamate/proline--tRNA ligase OS=Mus musculus GN=Eprs PE=1 SV=4 Q9D051 18 16 1388,08 7,96E-01 26289476,65 28901582,58 21415531,80 23498332,41 24860409,13 24825193,88 30059578,09 21883196,39 21102438,23 Serine/threonine-protein phosphatase CPPED1 OS=Mus musculus GN=Cpped1 PE=1 SV=1 Q9Z1J3 16 15 803,87 1,66E-03 231783,90 184040,64 322008,34 407211,09 379637,48 354715,80 507149,07 452665,41 474089,07 Ig heavy chain V-III region A4 OS=Mus musculus PE=1 SV=1 Q3ULD5 17 15 1293,85 4,79E-03 662277,16 701641,17 996702,87 774505,27 1141101,95 1036922,09 1094065,28 1409101,72 1117685,08 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Mus musculus GN=Ppp1ca PE=1 SV=1 Q9DCM2 15 15 967,81 3,40E-02 5135878,31 3756670,59 4457623,44 3856809,85 2952057,39 3382330,44 3211435,81 3222704,36 3514241,50 Beta- OS=Mus musculus GN=Eno3 PE=1 SV=3 P61979 17 15 969,61 4,23E-02 1240499,43 1141587,13 1055818,66 959344,38 888314,95 851605,32 963454,54 839298,22 825809,69 Guanylate-binding protein 1 OS=Mus musculus GN=Gbp2 PE=1 SV=1 P16332 15 15 907,53 1,09E-01 1176008,98 1327336,05 990097,35 1142494,22 1050983,69 1131266,91 625568,42 679987,74 1179483,30 Monocarboxylate transporter 1 OS=Mus musculus GN=Slc16a1 PE=1 SV=1 P45376 19 15 1067,38 1,21E-01 18690726,70 19155722,46 15660513,49 14065299,77 12511936,99 15817501,42 15743334,60 14448944,58 14335617,83 Lactation elevated protein 1 OS=Mus musculus GN=Lace1 PE=1 SV=1 Q9CXJ4 15 15 772,10 2,83E-01 227612,55 264251,93 446490,13 405218,74 380692,42 373217,62 362558,46 355300,46 363805,70 Surfeit protein 1 OS=Mus musculus GN=Surf1 PE=1 SV=3 P01942 15 15 1350,28 3,20E-01 6721015548,55 6129034560,89 1412678177,09 1291332221,82 1069654218,64 1071497685,49 7142870581,83 1849875684,88 982686176,56 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Mus musculus GN=Ndufb5 PE=1 SV=1 Q8BWF0 17 15 903,12 4,29E-01 1613031,63 1341728,40 1123753,52 1089692,32 1247203,56 933674,36 1194489,43 927801,51 1138039,58 Teashirt homolog 1 OS=Mus musculus GN=Tshz1 PE=1 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q9CR62 17 15 1101,33 4,43E-01 5676005,24 6839114,10 8781825,65 8378967,67 9770287,07 7039478,98 8616436,86 8174843,68 8074430,85 Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2 Q8VDM4 15 15 873,16 4,49E-01 234775,27 352225,28 280646,75 286606,61 273360,64 279387,89 213731,51 173293,74 299892,83 COP9 signalosome complex subunit 6 OS=Mus musculus GN=Cops6 PE=1 SV=1 P56399 18 15 889,54 4,86E-01 1190533,65 827261,01 681652,55 886254,66 1455551,06 862742,04 640968,04 545335,31 999945,70 -1,6-bisphosphatase isozyme 2 OS=Mus musculus GN=Fbp2 PE=1 SV=2 Q8VBT1 15 15 886,89 5,09E-01 264852,15 393688,63 402825,17 303629,08 307956,05 345245,95 220179,30 322765,89 424381,59 Neurolysin, mitochondrial OS=Mus musculus GN=Nln PE=1 SV=1 P50752;O88346 16 15 1145,99 6,07E-01 23041870,37 25679416,14 41206165,39 25939788,93 27508674,25 39563963,58 51076959,45 44534750,59 21191659,69 Cytoplasmic 1 intermediate chain 2 OS=Mus musculus GN=Dync1i2 PE=1 SV=1 Q9DCX2 15 15 1226,31 6,22E-01 53807781,16 64267889,45 48781517,25 47775832,32 50292045,73 45798765,80 85394768,55 46790754,24 52268825,59 Paladin OS=Mus musculus GN=Pald1 PE=1 SV=1 Q8K411 15 15 687,78 6,83E-01 356539,52 554127,64 381933,58 394854,26 424084,46 353071,44 334322,10 439600,09 481836,45 Methylmalonic aciduria type A homolog, mitochondrial OS=Mus musculus GN=Mmaa PE=1 SV=1 Q99LX0 16 15 1268,06 6,93E-01 6412967,66 8027581,30 6962177,93 7738244,87 6850405,44 7022307,48 5166353,50 6136388,92 8208842,13 inhibitor OS=Mus musculus GN=Rnh1 PE=1 SV=1 Q99J39 15 15 878,90 6,96E-01 879918,43 988913,62 791995,76 885583,29 970772,16 819557,99 837321,80 724950,06 1164919,73 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus GN=Usp9x PE=1 SV=2 P14824 18 15 956,72 8,78E-01 334606,96 384138,77 1208917,66 425168,51 428153,69 592009,53 1121529,85 786130,34 268405,62 -associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 E9PV24 16 14 973,03 5,48E-03 1238852,61 508211,50 677492,35 2573736,14 3463345,53 2537735,56 700407,96 1790653,17 749505,62 factor XIII A chain OS=Mus musculus GN=F13a1 PE=1 SV=3 Q76MZ3 26 14 1178,87 1,13E-02 2769197,92 2604384,59 2325243,48 1489088,00 3007057,13 1264688,15 1236755,00 969502,15 1369187,32 Coronin-1B OS=Mus musculus GN=Coro1b PE=1 SV=1 Q91VI7 15 14 903,15 3,08E-02 652231,91 625428,10 743425,62 938047,74 942174,12 857844,18 732533,66 686216,78 1120573,86 -2 OS=Mus musculus GN=Hk2 PE=1 SV=1 P14211 14 14 808,39 5,48E-02 4398709,97 3953414,23 2957298,47 2828568,43 2967547,01 3672757,98 3182555,35 1961422,89 3103183,70 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Mus musculus GN=Atpaf2 PE=1 SV=1 P53395 15 14 763,10 6,30E-02 1246024,52 1125345,11 1353020,61 1535036,19 1472277,12 1474645,81 1378565,80 1248272,79 1538034,78 Carnitine O-acetyltransferase OS=Mus musculus GN=Crat PE=1 SV=3 Q8CIB5 15 14 776,75 6,35E-02 1013570,06 1169056,02 729337,59 1185573,84 955873,33 1273175,64 1576681,61 1545054,55 1208342,74 Mothers against decapentaplegic homolog 2 OS=Mus musculus GN=Smad2 PE=1 SV=2 Q9Z1E4 14 14 719,77 9,23E-02 526942,53 502953,59 625756,23 778681,37 715728,14 677775,96 547578,16 605240,13 733526,44 Basic and W2 domain-containing protein 2 OS=Mus musculus molossinus GN=Bzw2 PE=2 SV=1 P17742;P30412 15 14 957,25 9,54E-02 33742189,96 34942736,14 6383189,46 6741744,47 6251230,66 7030625,61 9656262,65 7255719,47 6999876,29 Mitochondrial import receptor subunit TOM70 OS=Mus musculus GN=Tomm70a PE=1 SV=2 Q9Z2I8 16 14 1004,54 1,18E-01 2236194,38 2431420,20 1328046,76 1716675,59 2372562,01 2157912,25 2565375,26 2487026,67 3854360,56 Spermatid perinuclear RNA-binding protein OS=Mus musculus GN=Strbp PE=1 SV=1 Q9CXZ1 14 14 743,13 1,25E-01 6997225,57 6955549,01 5354626,20 3921625,39 3761939,55 3930463,71 7027064,82 4684727,73 3111522,07 Serine/threonine-protein kinase OSR1 OS=Mus musculus GN=Oxsr1 PE=1 SV=1 P50462 16 14 1354,35 1,26E-01 44294870,99 39756328,96 34819792,72 30634630,84 32061851,02 28062198,11 39994767,76 31090614,54 37541335,07 -C OS=Mus musculus GN=Flnc PE=1 SV=3 Q9ESD7 15 14 696,58 1,28E-01 54594,78 109460,55 46763,67 49694,90 111636,43 276964,65 123156,91 146814,02 202709,12 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 Q91VR2 15 14 1276,77 1,32E-01 32734397,84 33690255,43 29080977,42 28345166,31 25903763,49 25798415,44 35270420,32 41247683,88 25110536,47 Glutathione S-transferase kappa 1 OS=Mus musculus GN=Gstk1 PE=1 SV=3 P07901 27 14 1474,84 1,54E-01 1206682,75 987668,03 721841,66 919605,10 707823,81 706909,59 872501,23 623810,03 842103,56 Chloride intracellular channel protein 1 OS=Mus musculus GN=Clic1 PE=1 SV=3 Q8JZN5 19 14 1063,24 1,56E-01 1716481,59 2013488,69 1813495,38 2485727,15 2591738,04 2381695,75 1063463,57 1522211,12 2417135,51 WD repeat domain phosphoinositide-interacting protein 1 OS=Mus musculus GN=Wipi1 PE=1 SV=1 P97443 17 14 936,80 3,23E-01 1473536,47 1666170,04 1465293,57 2153127,13 1727963,01 1661211,91 2582101,14 1759050,21 2360784,29 Galectin-1 OS=Mus musculus GN=Lgals1 PE=1 SV=3 Q9D8N0 14 14 864,72 3,40E-01 933367,71 877757,41 1286170,27 1243140,30 1093100,70 1652974,46 1375458,07 1909751,87 1296918,92 -12 OS=Mus musculus GN=Snx12 PE=1 SV=1 P07759;P29621;Q80X76;Q5I2A022 14 1601,64 3,58E-01 34439513,19 8136172,54 5285115,46 15242296,14 9841452,95 6645508,61 9666701,90 2120622,49 6668849,43 B-type OS=Mus musculus GN=Ckb PE=1 SV=1 Q9D0E1 15 14 756,52 3,74E-01 204576,87 269586,79 295997,98 300416,09 336563,11 320360,23 234450,40 195234,59 340551,74 migration inhibitory factor OS=Mus musculus GN=Mif PE=1 SV=2 P62631 25 14 1500,27 3,87E-01 22552523,81 32415363,64 31187253,04 30438411,36 25295721,90 30965344,40 30433577,34 25758892,91 27890254,02 PDZ and LIM domain protein 1 OS=Mus musculus GN=Pdlim1 PE=1 SV=4 Q99KQ4 18 14 1038,74 4,34E-01 1685784,94 1265681,63 1899540,48 2078461,52 1998461,15 1938618,59 1099300,36 1218894,69 2183264,94 Ubiquinone monooxygenase COQ6, mitochondrial OS=Mus musculus GN=Coq6 PE=1 SV=3 O08709 14 14 1143,11 4,81E-01 6695094,98 7671746,96 8104686,17 6088345,30 6356648,76 6876829,19 6275254,57 6789275,36 7054165,90 OS=Mus musculus GN=Dmd PE=1 SV=3 Q9WUR2 15 14 1026,48 5,01E-01 3988292,02 3757166,96 3272534,80 3839207,19 4140045,98 3244257,81 3258275,56 4344764,32 4745632,91 Inter-alpha-trypsin inhibitor heavy chain H1 OS=Mus musculus GN=Itih1 PE=1 SV=2 P24527 15 14 749,15 5,19E-01 405968,10 422708,25 301759,59 410091,09 383989,91 353559,62 379238,94 283908,76 479959,38 28S ribosomal protein S11, mitochondrial OS=Mus musculus GN=Mrps11 PE=1 SV=2 O35857 16 14 859,70 7,00E-01 712784,18 814911,63 668663,64 743680,21 678527,35 667554,56 561503,32 732479,59 727158,03 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Mus musculus GN=Aimp2 PE=1 SV=2 Q9DBL1 16 14 922,20 7,52E-01 1611379,05 1768408,88 1955792,91 1905688,54 1845304,26 1903162,28 1610339,88 1969163,37 2048562,98 Trifunctional enzyme subunit alpha, mitochondrial OS=Mus musculus GN=Hadha PE=1 SV=1 P51667;Q62082 16 14 1164,80 9,71E-01 11667125,20 15481263,66 18092012,53 9353349,33 14202667,00 15728383,11 23281766,66 30119946,72 7859712,15 Protein NDRG1 OS=Mus musculus GN=Ndrg1 PE=1 SV=1 O88844 16 14 1003,78 9,96E-01 675172,72 666486,93 760006,05 693093,37 712091,96 691069,25 663139,15 475676,17 752165,28 TIP41-like protein OS=Mus musculus GN=Tiprl PE=1 SV=1 Q8VCM7 13 13 742,70 1,11E-02 1260190,75 464934,83 742952,28 2536463,05 3578707,73 2282213,44 462219,80 1643193,55 614007,95 Leukocyte elastase inhibitor A OS=Mus musculus GN=Serpinb1a PE=1 SV=1 Q60854 14 13 1041,06 1,33E-02 1424737,41 1447518,34 1603282,33 1178238,66 1392650,17 1229763,48 1426022,26 1630031,53 1570348,55 -dependent phosphatase 1 OS=Mus musculus GN=Mdp1 PE=1 SV=1 P09103 15 13 618,84 1,46E-02 709477,44 666051,46 536188,79 618383,10 614206,57 579009,85 547712,24 397714,79 626075,41 -4 OS=Mus musculus GN=Stx4 PE=1 SV=1 Q8R1S0 16 13 770,14 3,61E-02 1072489,97 1080391,47 986013,03 1153966,55 1353905,65 1255807,35 1271380,17 1081130,70 1237193,07 Splicing factor, arginine/serine-rich 19 OS=Mus musculus GN=Scaf1 PE=1 SV=1 O70250 19 13 1359,07 8,27E-02 35233639,76 36686099,72 27045299,43 28717740,07 26410501,36 27542672,87 31102380,24 25581192,35 31671924,98 inhibitor A3N OS=Mus musculus GN=Serpina3n PE=1 SV=1 P23953 14 13 928,41 8,92E-02 2378640,37 1231559,35 1585055,39 1153117,94 1146588,14 1268909,57 2008504,37 625791,17 906410,38 Leukocyte surface antigen CD47 OS=Mus musculus GN=Cd47 PE=1 SV=2 P80314 13 13 867,03 1,26E-01 437223,26 391771,80 690669,48 508136,83 729565,66 636766,50 425497,13 355315,67 534305,45 Ras suppressor protein 1 OS=Mus musculus GN=Rsu1 PE=1 SV=3 P67778 14 13 859,97 1,82E-01 1222138,28 1196873,31 1904232,95 1453233,10 2064966,32 1473191,73 3079143,37 2448558,71 1653658,83 Mitochondrial carnitine/acylcarnitine carrier protein OS=Mus musculus GN=Slc25a20 PE=1 SV=1 Q9CR68;P55041 13 13 745,07 2,00E-01 11617285,36 12449408,72 14276491,34 10689700,05 11003690,78 11255290,35 19078417,46 15342886,00 11420266,60 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Mus musculus GN=Ddost PE=1 SV=2 O08529 15 13 762,01 2,22E-01 400655,09 411103,44 410820,79 338631,39 360277,23 466920,74 375797,41 281089,32 401678,19 reductase A OS=Mus musculus GN=Blvra PE=1 SV=1 Q8K0D5 14 13 680,52 2,26E-01 760764,29 569976,27 465107,56 583736,11 563879,23 485119,31 435541,72 331607,56 524324,87 Ubiquitin-conjugating enzyme E2 L3 OS=Mus musculus GN=Ube2l3 PE=1 SV=1 P62897;P00015 13 13 1046,30 2,33E-01 163140912,11 216119352,57 113840899,19 145740865,33 144116059,62 131814369,27 197347458,48 118784042,72 166596515,42 Translocon-associated protein subunit gamma OS=Mus musculus GN=Ssr3 PE=1 SV=1 P31001;P08551 18 13 1080,32 3,04E-01 302031,07 368267,18 570943,90 349305,49 344406,24 318758,43 382153,93 558116,18 466712,16 NADH dehydrogenase [ubiquinone] -sulfur protein 6, mitochondrial OS=Mus musculus GN=Ndufs6 PE=1 SV=2 Q9QUR6 16 13 853,71 3,41E-01 393783,33 383414,54 300464,05 361743,84 303442,98 384958,29 222564,05 226094,80 375899,70 Vesicular integral-membrane protein VIP36 OS=Mus musculus GN=Lman2 PE=1 SV=2 P48036 14 13 885,99 3,67E-01 1261970,41 2306452,51 2256272,87 2790974,67 2617026,55 2504407,03 1833837,62 1954064,31 2844549,86 4-trimethylaminobutyraldehyde dehydrogenase OS=Mus musculus GN=Aldh9a1 PE=1 SV=1 Q9WTP7 13 13 703,61 3,87E-01 2289869,86 2602546,48 1908098,82 2343984,26 2004088,53 2343854,40 2018673,09 2268595,66 2449678,84 Cytoplasmic dynein 1 light intermediate chain 2 OS=Mus musculus GN=Dync1li2 PE=1 SV=2 Q9CPY7 15 13 953,05 4,04E-01 1337025,71 1264973,04 1019171,73 1372174,55 1663415,29 1457594,67 970240,85 1102726,15 1777633,11 assembly factor 4, mitochondrial OS=Mus musculus GN=Sdhaf4 PE=3 SV=2 Q9EQH3 14 13 697,86 4,40E-01 433343,74 405383,38 563187,25 614239,87 570170,65 507395,46 557263,94 533686,69 642616,82 Ezrin OS=Mus musculus GN=Ezr PE=1 SV=3 P35564 15 13 732,01 4,79E-01 1437739,61 1524074,90 1150479,45 1376098,45 1525631,54 1291219,63 1467916,54 857736,16 1342770,91 Cofilin-1 OS=Mus musculus GN=Cfl1 PE=1 SV=3 Q8C129 13 13 712,29 5,22E-01 275849,16 422793,01 340043,24 368666,84 302631,72 247289,16 431360,03 293962,70 325558,03 Dimethylaniline monooxygenase [N-oxide-forming] 1 OS=Mus musculus GN=Fmo1 PE=1 SV=1 Q9WUM5 14 13 993,33 7,35E-01 29238567,42 29117450,04 15445634,82 20227252,11 21120870,19 18992625,36 22315085,13 20730584,54 25621160,71 Transmembrane protein 177 OS=Mus musculus GN=Tmem177 PE=1 SV=1 P97447 14 13 710,58 7,81E-01 927065,09 862460,91 766484,60 856293,25 733756,36 799587,24 1238031,82 942894,38 767066,94 Metaxin-2 OS=Mus musculus GN=Mtx2 PE=1 SV=1 P09671 14 13 1089,02 9,63E-01 43305091,82 48456882,72 36514009,18 39506621,49 45068785,24 38774643,94 31213966,66 32113332,76 48544899,45 Proteasome subunit beta type-2 OS=Mus musculus GN=Psmb2 PE=1 SV=1 Q9QYR9;Q32Q92;Q8BWN823 12 1695,14 3,44E-03 6308887,73 5332904,03 5914396,95 8004028,68 8605184,73 6900447,54 7235950,56 12508835,51 12853021,48 Ras-related protein -33B OS=Mus musculus GN=Rab33b PE=1 SV=1 Q9WVJ2 13 12 588,64 6,07E-03 282394,24 212415,35 236652,28 269733,63 320361,49 374509,51 525550,12 362835,55 374503,70 Protein phosphatase 1 regulatory subunit 14C OS=Mus musculus GN=Ppp1r14c PE=1 SV=1 Q61646 15 12 852,85 7,47E-03 656544,79 978904,34 913009,31 3522480,61 3211644,67 1694995,62 956651,63 885099,42 294369,01 -2 OS=Mus musculus GN=Pfn2 PE=1 SV=3 P32020 13 12 703,23 8,30E-03 2227896,24 1879508,80 1833431,16 2427677,77 1638949,53 1856773,88 2687192,90 3730987,63 3251891,25 Transaldolase OS=Mus musculus GN=Taldo1 PE=1 SV=2 P51660 12 12 591,57 2,14E-02 391698,76 476215,18 529047,26 450967,68 544938,49 432339,04 526190,84 872003,91 608835,78 Vacuole membrane protein 1 OS=Mus musculus GN=Vmp1 PE=1 SV=2 Q9Z2Z6 12 12 567,11 3,85E-02 787679,86 697368,73 1238995,26 1044120,28 1257730,28 938076,18 2169634,37 2313898,96 1179106,88 O-acetyl-ADP-ribose deacetylase MACROD1 OS=Mus musculus GN=Macrod1 PE=1 SV=2 Q9D172 13 12 1006,02 4,95E-02 33808704,89 29010361,43 31925164,08 26601075,49 31073418,08 24558116,53 38041142,02 37877895,78 34613006,45 Heterogeneous nuclear ribonucleoprotein K OS=Mus musculus GN=Hnrnpk PE=1 SV=1 Q91ZJ5 14 12 786,56 8,65E-02 1762927,39 1620165,67 1456382,92 2061378,23 1961687,90 1784377,28 1139697,42 1186193,21 1841868,98 Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Mus musculus GN=Fkbp4 PE=1 SV=5 Q8BGH2 13 12 849,60 1,02E-01 739324,49 731782,18 2071674,04 1485203,10 1397376,72 1589331,70 2895421,92 2316538,61 1745116,62 Heparin 2 OS=Mus musculus GN=Serpind1 PE=1 SV=1 Q64737 12 12 644,82 1,43E-01 381606,90 452076,96 401001,27 319907,68 371802,18 428216,56 234197,90 384854,91 375314,23 Oxysterol-binding protein 1 OS=Mus musculus GN=Osbp PE=1 SV=3 O55126 14 12 993,04 1,44E-01 33136856,60 33520002,31 25616349,75 24236405,87 25805061,44 23900227,45 31085323,63 28815857,69 23614075,81 Acyl-coenzyme A thioesterase 3 OS=Mus musculus GN=Acot3 PE=1 SV=1 Q61738 12 12 484,42 1,46E-01 281834,30 327269,19 335937,29 244195,29 313307,68 254882,85 242973,12 298086,21 252259,17 Probable hydrolase PNKD OS=Mus musculus GN=Pnkd PE=1 SV=2 Q9WU78 14 12 821,04 1,70E-01 189473,03 235602,85 176923,66 274656,95 253650,32 231612,54 212294,24 210843,75 352794,95 Proteasome activator complex subunit 1 OS=Mus musculus GN=Psme1 PE=1 SV=2 Q9WVA4;Q9R1Q8 13 12 688,47 1,72E-01 6907805,89 4051813,18 5055824,98 5677562,98 4500400,20 4221510,90 6609138,01 6147712,35 6032841,27 E synthase 2 OS=Mus musculus GN=Ptges2 PE=1 SV=3 P51125 13 12 983,01 1,85E-01 314000,34 304339,40 303119,17 266557,11 357530,08 378956,36 254827,47 258381,30 417517,68 Protein phosphatase 1 regulatory subunit 11 OS=Mus musculus GN=Ppp1r11 PE=1 SV=1 Q1XH17 12 12 791,10 2,12E-01 1540022,79 1158776,95 1436242,65 1287259,64 1486464,65 1267447,52 981816,48 1108474,55 1185811,21 RuvB-like 2 OS=Mus musculus GN=Ruvbl2 PE=1 SV=3 P62259 18 12 1087,17 2,97E-01 4634475,21 4666998,38 3218638,06 3761694,77 2646956,52 3310460,04 4582518,68 4405467,92 3471973,43 ATP-dependent RNA helicase DDX19A OS=Mus musculus GN=Ddx19a PE=1 SV=2 Q9JLV1 14 12 869,96 3,03E-01 375907,30 339510,56 338665,13 361729,41 446934,99 466201,69 221110,56 294859,39 386216,68 Neutral ester hydrolase 1 OS=Mus musculus GN=Nceh1 PE=1 SV=1 Q78IK4 12 12 765,64 3,23E-01 924783,85 1087957,11 1503922,03 1309943,19 1336818,33 1386893,48 1239340,60 1500752,17 1239897,92 ATP-dependent RNA helicase A OS=Mus musculus GN=Dhx9 PE=1 SV=2 P19783 12 12 693,41 3,67E-01 20788039,04 17782688,28 24146407,25 19084537,22 21879940,09 17319655,13 30927759,93 26782634,49 16480125,65 Eukaryotic translation initiation factor 2 subunit 3, X-linked OS=Mus musculus GN=Eif2s3x PE=1 SV=2 P00920 13 12 1128,22 3,80E-01 64075408,13 47075435,93 12981261,97 12520321,87 9612439,49 7174223,90 66865536,49 14079432,68 8070382,49 alpha-1A chain OS=Mus musculus GN=Tuba1a PE=1 SV=1 P50247 14 12 682,12 3,85E-01 1065269,74 1035580,26 705006,70 774890,35 578996,23 689512,23 1071585,73 769448,73 840379,49 Eukaryotic translation initiation factor 5A-1 OS=Mus musculus GN=Eif5a PE=1 SV=2 O09131;Q8K2Q2 14 12 709,15 4,47E-01 3179353,10 2733494,75 2677731,14 2097059,32 2628793,37 2336394,83 2605718,44 2748922,17 2396708,86 alpha chain, erythrocytic 1 OS=Mus musculus GN=Spta1 PE=1 SV=3 Q923D2 13 12 681,08 6,13E-01 8644501,68 5621125,25 1821389,17 2722147,69 2412557,22 2079912,28 7700426,63 2547444,28 2014824,59 28S ribosomal protein S9, mitochondrial OS=Mus musculus GN=Mrps9 PE=1 SV=3 P80318 12 12 747,87 6,24E-01 322540,91 421979,71 316190,89 341543,12 376439,50 384889,95 269227,01 209896,54 396024,13 Alpha-1- glycoprotein 1 OS=Mus musculus GN=Orm1 PE=1 SV=1 Q64669 13 12 479,96 6,73E-01 704521,03 903676,91 689678,27 817979,73 967403,77 603022,32 685906,49 947656,94 1019275,97 Perilipin-4 OS=Mus musculus GN=Plin4 PE=1 SV=2 Q3UIZ8;O08911 14 12 695,63 7,73E-01 596500,05 555953,33 473279,82 239648,92 640220,68 388579,14 353068,46 306890,64 676150,13 Protein FAM185A OS=Mus musculus GN=Fam185a PE=2 SV=1 O35855 14 12 911,62 8,03E-01 8878060,05 4611003,01 3405563,85 4944200,90 5379369,66 3387710,63 6424135,99 3704279,78 6115227,33 -5 OS=Mus musculus GN=Cul5 PE=1 SV=3 A2AAJ9 14 12 649,74 8,25E-01 173078,17 224480,84 396495,75 330720,05 280697,39 247186,23 197215,57 264688,01 222583,73 NADH-ubiquinone chain 5 OS=Mus musculus GN=Mtnd5 PE=1 SV=3 Q5SW19 13 12 658,13 8,49E-01 182645,50 156104,43 235527,14 183252,56 183034,14 210914,07 188147,00 160765,69 201066,35 Nebulin-related-anchoring protein OS=Mus musculus GN=Nrap PE=1 SV=3 P15626 24 12 1346,18 8,68E-01 3263653,42 3604725,22 4644723,62 3322445,23 3468074,68 4875420,30 3613905,64 4577024,77 4067814,35 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Mus musculus GN=Ecsit PE=1 SV=2 O08553;P97427 15 12 916,65 9,37E-01 1276722,15 1768477,96 1690070,10 1707239,82 1637567,26 1627457,58 1849278,23 1374128,15 1854933,58 Coiled-coil domain-containing protein 51 OS=Mus musculus GN=Ccdc51 PE=1 SV=1 P37804 14 12 790,69 9,58E-01 1314270,95 2033489,79 1608324,50 2767453,76 1237731,49 972028,14 2633205,64 874413,98 1250319,55 Ragulator complex protein LAMTOR3 OS=Mus musculus GN=Lamtor3 PE=1 SV=1 P19324 12 11 608,71 5,08E-04 314530,83 271074,78 335588,00 302078,49 341057,90 370378,71 206635,20 202325,83 238024,92 MICOS complex subunit Mic60 OS=Mus musculus GN=Immt PE=1 SV=1 Q99KR7;Q9QZH3 12 11 745,67 3,28E-03 3648597,15 4183866,73 3528219,20 4293599,74 4963888,60 4750543,15 4365114,79 4556683,01 5349103,68 Monoglyceride OS=Mus musculus GN=Mgll PE=1 SV=1 Q9R1P4 11 11 511,89 1,34E-02 693906,69 748484,74 714063,38 947233,85 742582,79 879209,15 776556,40 854997,81 879856,51 ATP-binding cassette sub-family D member 3 OS=Mus musculus GN=Abcd3 PE=1 SV=2 Q8VCW8 11 11 600,60 2,12E-02 231017,46 257445,17 273344,81 304798,28 300014,79 381884,25 228441,13 262280,68 405123,42 Inositol monophosphatase 2 OS=Mus musculus GN=Impa2 PE=1 SV=1 O70571 12 11 714,55 2,30E-02 452004,28 441222,25 246219,23 546812,07 804925,93 517350,78 540447,58 1857638,81 795885,35 Ubiquitin-40S ribosomal protein S27a OS=Mus musculus GN=Rps27a PE=1 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P20108 11 11 828,98 2,45E-02 16179873,24 15028868,05 12911049,65 11758485,19 11735712,59 11167967,70 13024714,25 9890870,81 9220633,84 ES1 protein homolog, mitochondrial OS=Mus musculus GN=D10Jhu81e PE=1 SV=1 P26040 25 11 1072,58 4,05E-02 417582,19 457034,32 428436,77 318331,44 367615,14 332055,53 364197,16 323018,15 406992,00 Solute carrier family 12 member 7 OS=Mus musculus GN=Slc12a7 PE=1 SV=1 Q93092 11 11 414,35 4,21E-02 1067840,20 985684,64 1147253,66 953013,30 756055,83 836176,71 940290,15 919054,15 1007317,30 -like 120 kDa protein, mitochondrial OS=Mus musculus GN=Opa1 PE=1 SV=1 Q922B1 11 11 759,32 4,23E-02 6056245,77 6225141,08 4516465,14 4237637,20 4974026,61 3863090,14 4069176,57 3919042,18 4774672,48 Threonine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Tars PE=1 SV=2 O55222 12 11 498,02 5,52E-02 372570,01 466956,39 306945,87 561580,47 506094,60 676451,17 474135,98 376229,90 622184,43 Sodium/-transporting ATPase subunit beta-3 OS=Mus musculus GN=Atp1b3 PE=1 SV=1 Q8K1Z0 12 11 908,50 6,61E-02 12071393,56 13451259,38 11888450,12 10458889,81 10933624,36 10899702,17 9362013,26 11781303,74 10705608,81 Proliferation-associated protein 2G4 OS=Mus musculus GN=Pa2g4 PE=1 SV=3 Q9CPV4 13 11 660,37 9,41E-02 926431,34 835331,01 930430,23 902986,64 1032917,81 935117,02 836089,42 813097,91 902915,92 Hydroxysteroid dehydrogenase-like protein 2 OS=Mus musculus GN=Hsdl2 PE=1 SV=1 P13707 14 11 606,51 1,20E-01 255315,64 283258,00 295907,98 284048,62 260139,22 240205,28 205715,02 214831,28 293452,64 Coronin-1A OS=Mus musculus GN=Coro1a PE=1 SV=5 P59017 12 11 563,93 1,31E-01 1136269,40 1234990,03 1039766,29 1623809,52 1801828,11 1278101,83 1035030,80 1280403,99 1597805,62 NADH- reductase 1 OS=Mus musculus GN=Cyb5r1 PE=1 SV=1 P23506 12 11 615,92 1,38E-01 1536691,15 1400383,54 1005419,27 1298477,11 1207068,16 1191384,48 806686,33 727473,10 987048,31 NIF3-like protein 1 OS=Mus musculus GN=Nif3l1 PE=1 SV=4 P35235 12 11 581,60 1,41E-01 304982,95 343380,59 299422,59 518619,41 459878,22 457674,98 314487,71 243215,98 492137,84 Trimeric intracellular cation channel type A OS=Mus musculus GN=Tmem38a PE=1 SV=2 Q8CI51 12 11 748,27 1,41E-01 9986383,20 13521856,20 10320684,78 10255715,88 10382451,35 11493492,14 8160351,89 8800162,53 9642376,40 OS=Mus musculus GN=Rpl8 PE=1 SV=2 O08677 12 11 557,32 1,47E-01 5946188,86 3731478,34 3694778,48 4220715,85 5276335,93 4350872,72 4227175,52 2842080,12 4406508,46 AP-2 complex subunit alpha-2 OS=Mus musculus GN=Ap2a2 PE=1 SV=2 Q02257 13 11 629,94 1,57E-01 159665,44 115212,47 155677,81 172077,70 180564,96 216179,89 150078,37 215385,02 144363,00 Histone H4 OS=Mus musculus GN=Hist1h4a PE=1 SV=2 Q8BKZ9 15 11 820,01 1,66E-01 2952192,18 3032545,13 3653991,10 2133612,81 2896725,59 2551885,77 3143442,62 3310303,14 1664436,17 A-kinase anchor protein 1, mitochondrial OS=Mus musculus GN=Akap1 PE=1 SV=4 Q00519 14 11 890,16 1,77E-01 258323,78 390090,92 348123,48 512818,65 441108,57 518988,00 292398,24 414875,76 562528,16 Proteasome activator complex subunit 3 OS=Mus musculus GN=Psme3 PE=1 SV=1 Q9DBJ1 16 11 1061,96 1,91E-01 3612879,01 4526173,68 3219535,08 3338061,93 3520133,56 4041228,22 3739102,89 2660887,84 3933325,97 Glutathione S-transferase A4 OS=Mus musculus GN=Gsta4 PE=1 SV=3 Q05920 12 11 583,43 2,15E-01 195237,15 175873,61 178011,11 208852,93 379080,56 480209,73 272473,15 203755,01 438218,03 Heterogeneous nuclear ribonucleoprotein F OS=Mus musculus GN=Hnrnpf PE=1 SV=3 P40142 12 11 624,72 2,19E-01 5194007,54 7409014,16 3920496,07 12792431,61 6376965,87 8942096,96 4470658,22 6210947,48 14107008,89 Probable proline--tRNA ligase, mitochondrial OS=Mus musculus GN=Pars2 PE=1 SV=2 Q9DCT2 12 11 813,50 2,24E-01 7930019,57 6663476,75 7724672,57 6158632,35 6603026,31 7478093,21 10358882,13 7650705,76 5876467,85 Membrane primary amine oxidase OS=Mus musculus GN=Aoc3 PE=1 SV=3 Q811U4 12 11 571,46 2,28E-01 80970,71 162591,35 130100,10 131318,47 190071,68 169599,44 170758,61 179087,79 160510,52 Vacuolar protein sorting-associated protein 26A OS=Mus musculus GN=Vps26a PE=1 SV=1 Q8VDQ1 12 11 766,26 2,29E-01 1541408,09 1757601,17 1928799,59 2011087,11 2107694,27 1734824,77 1230184,96 1092519,06 2548032,84 dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=1 SV=1 O35129 15 11 695,62 2,34E-01 1289360,75 996754,11 1665355,40 1433310,58 1888656,46 1291711,30 2538816,31 2413589,50 1268759,70 tRNA-splicing ligase RtcB homolog OS=Mus musculus GN=Rtcb PE=1 SV=1 P19157;P46425 12 11 966,22 2,40E-01 10806176,59 9769239,64 6290546,37 5285798,56 4531278,35 5226200,86 11008021,75 5341135,73 6664400,03 OS=Mus musculus GN=Calr PE=1 SV=1 Q8K3J1 14 11 839,36 2,49E-01 4673488,54 4648378,15 4043513,44 3234350,87 3465545,64 3642030,85 5113510,42 3510391,69 2964924,24 subunit 7C, mitochondrial OS=Mus musculus GN=Cox7c PE=1 SV=1 Q8R4N0 12 11 749,35 2,53E-01 1727580,05 2232711,32 2035642,58 1929966,57 2136370,07 1511831,61 1166817,07 1589014,68 1911017,97 Alpha-2-macroglobulin-P OS=Mus musculus GN=A2mp PE=2 SV=2 P35700 17 11 1070,36 2,59E-01 12633093,60 12463867,59 8912421,99 8790859,90 8043924,73 8334086,86 10763889,79 7926783,54 9884324,47 -linked protein kinase OS=Mus musculus GN=Ilk PE=1 SV=2 P99029 12 11 848,45 2,60E-01 34110680,69 34391232,10 21902386,16 21637350,35 22527888,59 20021475,71 27818697,80 25116405,68 24603129,66 6-phosphogluconolactonase OS=Mus musculus GN=Pgls PE=1 SV=1 Q61598 16 11 1021,60 2,83E-01 1493850,21 1652352,17 1127763,42 1528542,65 1711812,05 1648649,56 1772062,46 1141422,07 1705070,08 Disks large homolog 1 OS=Mus musculus GN=Dlg1 PE=1 SV=1 P70296 11 11 917,86 2,87E-01 18440914,02 18367546,57 14147328,83 12421039,74 14280752,97 11916023,44 13800001,85 10845313,26 14508401,03 protein 4-like protein 1 OS=Mus musculus GN=Pcp4l1 PE=1 SV=1 Q3ULJ0 13 11 717,44 2,98E-01 1337426,13 1168760,71 764813,50 871555,66 836707,96 865492,40 995367,05 1568336,81 1155556,50 SPRY domain-containing protein 7 OS=Mus musculus GN=Spryd7 PE=1 SV=2 P23492 11 11 674,55 3,50E-01 1569762,57 1164755,64 1856618,30 2401544,95 1889341,45 2060938,55 1167188,19 1393264,03 2032631,46 Profilin-1 OS=Mus musculus GN=Pfn1 PE=1 SV=2 Q3URD3 12 11 705,82 4,69E-01 275274,50 242689,55 327308,16 289566,15 283544,86 239964,46 404826,89 319133,13 243329,89 -2 OS=Mus musculus GN=Casq2 PE=1 SV=3 P80315 13 11 744,29 4,82E-01 421680,86 353383,87 395514,39 423160,35 399368,12 451165,88 430751,84 385679,04 354921,64 E3 ubiquitin-protein ligase NEDD4 OS=Mus musculus GN=Nedd4 PE=1 SV=3 Q8BZF8 14 11 642,05 4,96E-01 581210,68 688218,75 529477,49 524991,21 571403,57 508046,42 543855,92 415305,52 572133,23 Transmembrane 9 superfamily member 2 OS=Mus musculus GN=Tm9sf2 PE=1 SV=1 P09528 11 11 570,17 5,38E-01 3426595,01 2754613,18 4315500,55 5743300,18 4124917,41 3854604,80 3476272,85 3210161,39 5562142,01 DCN1-like protein 2 OS=Mus musculus GN=Dcun1d2 PE=1 SV=3 Q8BGK2 11 11 690,87 7,24E-01 3840674,27 2796600,21 2064008,31 2692387,16 2594839,59 3305506,52 2720907,32 2592951,30 4000859,51 Vesicle-associated membrane protein 3 OS=Mus musculus GN=Vamp3 PE=1 SV=1 Q924D0 11 11 644,39 7,44E-01 1238428,72 1309927,30 1179709,78 1307609,46 1653235,62 1289951,03 1464498,06 1018638,62 1453143,19 delta-1 OS=Mus musculus GN=Ctnnd1 PE=1 SV=2 Q3UTJ2 14 11 532,02 8,43E-01 449456,61 727893,20 340518,58 501908,58 479159,12 502668,31 573815,01 448439,98 509587,91 Protein FAM49B OS=Mus musculus GN=Fam49b PE=1 SV=1 Q61768 17 11 988,52 9,00E-01 179747,26 223119,83 239631,59 209846,33 182816,18 215009,75 239802,01 153446,70 201662,61 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadvl PE=1 SV=3 Q8BW75 12 11 584,17 9,31E-01 1313035,10 2017318,18 1490106,60 1247677,02 1220039,14 1783204,22 2454434,34 1727998,44 1108362,44 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Mus musculus GN=Trmu PE=1 SV=1 Q9CXI0 10 10 602,45 1,87E-02 556539,42 654180,62 430784,50 754500,10 709980,74 738478,92 1105652,82 649137,57 838395,12 Mitochondrial import inner membrane subunit Tim13 OS=Mus musculus GN=Timm13 PE=1 SV=1 Q14C51 10 10 341,05 1,92E-02 107734,53 96575,38 129473,90 201167,22 205059,10 199950,43 74648,82 95483,25 172073,02 Heterogeneous nuclear ribonucleoprotein A/B OS=Mus musculus GN=Hnrnpab PE=1 SV=1 Q8BH61 10 10 387,11 3,11E-02 100743,88 104858,24 121020,34 125998,74 116915,84 121013,03 132303,07 98208,72 137593,17 Ribose-phosphate pyrophosphokinase 2 OS=Mus musculus GN=Prps2 PE=1 SV=4 Q01730 11 10 579,18 3,85E-02 941330,48 1133331,40 763406,61 997310,24 954638,56 1162614,15 675062,21 818078,17 843192,25 14-3-3 protein theta OS=Mus musculus GN=Ywhaq PE=1 SV=1 P30416 10 10 466,42 4,25E-02 355832,73 287289,50 322780,59 332182,33 266558,62 321091,45 226976,61 215500,72 269799,03 aminopeptidase 2 OS=Mus musculus GN=Metap2 PE=1 SV=1 Q8BWM0 11 10 646,43 4,45E-02 639458,18 647469,13 621721,63 879667,23 963037,12 970136,45 855449,89 604020,09 1070616,41 Transmembrane emp24 domain-containing protein 10 OS=Mus musculus GN=Tmed10 PE=1 SV=1 O35658 10 10 647,42 8,35E-02 2099028,70 2966066,60 2519926,21 3521562,88 2964896,19 5568897,97 3621925,20 3826499,34 3812808,11 subunit B type 1 OS=Mus musculus GN=Ppp3r1 PE=1 SV=3 Q8K370 11 10 417,60 1,11E-01 1998380,02 2431194,70 1649470,90 1552956,22 1448181,04 1699011,84 1540423,74 1507188,02 1310783,37 Alpha-1-antitrypsin 1-1 OS=Mus musculus GN=Serpina1a PE=1 SV=4 P54822 10 10 494,74 1,33E-01 729516,88 871393,25 773482,25 925838,32 856204,91 798755,07 775193,91 759283,81 853615,82 Glypican-1 OS=Mus musculus GN=Gpc1 PE=1 SV=1 P11152;Q9WVG5 11 10 516,11 1,75E-01 941776,75 1151592,58 1005258,21 1536584,88 1195853,57 1303544,33 1278711,98 766310,88 1488052,35 ATP synthase subunit a OS=Mus musculus GN=Mtatp6 PE=1 SV=1 Q922B2 10 10 553,10 1,79E-01 355282,62 371769,72 267781,12 293947,16 209366,84 241013,01 269265,96 241028,46 225385,45 Transmembrane protein 160 OS=Mus musculus GN=Tmem160 PE=2 SV=1 P10518 10 10 574,54 1,97E-01 434219,42 463608,07 628449,64 467837,73 562959,13 647821,49 490793,56 466193,04 538379,74 von Willebrand factor OS=Mus musculus GN=Vwf PE=1 SV=2 Q9R111 10 10 644,55 2,02E-01 326711,60 302240,06 97420,99 141897,45 56547,46 82553,48 403834,83 99512,14 89416,52 Eukaryotic initiation factor 4A-II OS=Mus musculus GN=Eif4a2 PE=1 SV=2 O88685 13 10 606,12 2,37E-01 325527,41 396465,32 520961,41 543871,22 643090,31 434752,03 530799,41 509200,32 577722,90 Myozenin-2 OS=Mus musculus GN=Myoz2 PE=1 SV=1 P23927 12 10 957,94 2,85E-01 23310216,89 18083813,35 14029116,53 16422554,45 15408338,68 17633474,39 19022882,40 18508848,91 22060506,87 Heat shock 70 kDa protein 12A OS=Mus musculus GN=Hspa12a PE=1 SV=1 Q9D855 11 10 592,57 2,91E-01 30559353,70 29320881,61 21824230,97 19979681,24 21298289,71 18678879,11 38872971,45 25461058,61 20762760,08 Complement component C9 OS=Mus musculus GN=C9 PE=1 SV=2 Q7TMF3 11 10 786,05 2,96E-01 4975700,61 5292050,12 6874889,18 5208754,57 5760996,92 5542976,02 5813376,23 5652902,90 4505765,37 Anamorsin OS=Mus musculus GN=Ciapin1 PE=1 SV=1 Q6IRU2 13 10 742,17 2,96E-01 1647165,39 1331246,43 466012,96 1474805,90 412932,71 1611489,93 603975,47 479878,89 299125,35 Tubulin alpha-4A chain OS=Mus musculus GN=Tuba4a PE=1 SV=1 Q99P72 10 10 380,47 3,10E-01 198890,50 314193,91 442150,62 355612,11 496992,58 520516,59 391168,71 317164,40 439047,54 alpha-1(XV) chain OS=Mus musculus GN=Col15a1 PE=1 SV=2 Q62425 10 10 1046,10 3,10E-01 53788342,15 57016901,56 50049294,84 55279967,00 60206652,50 63894410,22 68564105,84 60818057,61 55131331,48 Reticulocalbin-3 OS=Mus musculus GN=Rcn3 PE=1 SV=1 Q149B8 10 10 623,08 3,26E-01 463059,94 459800,85 571049,10 649509,95 723129,97 544216,78 399308,77 447113,92 657430,27 -1 catalytic subunit OS=Mus musculus GN=Capn1 PE=1 SV=1 P80316 12 10 606,31 3,27E-01 420906,83 395487,13 418521,92 397506,57 414243,55 465946,95 386757,58 390766,97 389744,37 -6-phosphate isomerase OS=Mus musculus GN=Gpi PE=1 SV=4 P14602 13 10 835,87 3,40E-01 10752313,86 8613993,99 4821541,80 6071875,51 5492190,45 6779227,04 5849074,79 5481962,37 7020075,09 ATP synthase F(0) complex subunit C1, mitochondrial OS=Mus musculus GN=Atp5g1 PE=2 SV=1 P50396 16 10 1041,96 3,44E-01 751039,93 856439,28 858789,67 917517,79 639626,35 607539,86 785803,45 629477,93 599744,51 Glycogenin-1 OS=Mus musculus GN=Gyg1 PE=1 SV=3 O88569 11 10 753,19 3,47E-01 1456908,37 1889294,99 1143372,23 1034032,21 886745,72 1187408,13 2138227,99 1337340,48 1106791,75 Glycogen , form OS=Mus musculus GN=Pygl PE=1 SV=4 P15327 10 10 649,12 3,51E-01 3319975,34 3618840,10 785777,39 722659,57 675579,77 513910,67 4417175,12 895401,20 616041,80 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dbt PE=1 SV=2 P10649;A4Q9F0 21 10 1384,61 3,62E-01 9880365,20 14090445,50 12151504,17 10377830,03 9072468,62 10421266,45 12044386,73 11323336,16 11726041,73 Growth factor receptor-bound protein 2 OS=Mus musculus GN=Grb2 PE=1 SV=1 P42932 10 10 581,92 3,90E-01 931775,10 827484,70 643631,17 683546,36 660459,45 765350,16 776378,05 711218,56 772281,70 Small ubiquitin-related modifier 2 OS=Mus musculus GN=Sumo2 PE=1 SV=1 Q60930 11 10 833,78 4,51E-01 3112521,17 2770603,51 1778961,55 2061332,54 2007996,69 1649179,11 4127919,47 2796764,54 1779854,87 Cell division control protein 42 homolog OS=Mus musculus GN=Cdc42 PE=1 SV=2 P23242 11 10 830,93 4,79E-01 385258,11 554991,46 1978311,62 796755,83 836104,18 650937,81 1396825,06 1594328,43 861098,01 Fermitin family homolog 2 OS=Mus musculus GN=Fermt2 PE=1 SV=1 Q9QYJ0 12 10 705,25 4,96E-01 613297,43 399037,74 492631,17 403288,85 495852,87 551702,38 448138,90 389085,71 458375,44 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Mus musculus GN=Fnta PE=1 SV=1 Q8K1B8 14 10 740,60 5,32E-01 147152,72 83969,17 16225,06 9025,35 37011,42 297273,33 167592,72 47929,23 12249,00 Protein transport protein Sec31A OS=Mus musculus GN=Sec31a PE=1 SV=2 Q9D0M3 12 10 1048,51 5,52E-01 32347761,18 31653217,84 41438231,14 28323504,72 36989191,80 31851547,91 52416853,47 43518090,84 26743765,00 Microfibril-associated glycoprotein 4 OS=Mus musculus GN=Mfap4 PE=1 SV=1 P29758 10 10 632,17 6,22E-01 1473771,92 1998463,16 1021948,82 1298075,02 1119069,72 1316191,43 1171282,95 1120272,72 1413480,93 Integrin alpha-6 OS=Mus musculus GN=Itga6 PE=1 SV=3 P02089 20 10 2027,54 6,31E-01 1006331570,19 384989058,78 78232983,78 131353296,40 80737735,48 154447115,60 718428741,82 123318833,00 114505640,32 PKM OS=Mus musculus GN=Pkm PE=1 SV=4 Q9JMA1 11 10 707,69 6,75E-01 331806,52 411119,62 376297,63 339064,83 791544,65 361124,70 438358,39 354804,74 529840,60 Poly(rC)-binding protein 2 OS=Mus musculus GN=Pcbp2 PE=1 SV=1 Q9CZR8 10 10 621,64 6,76E-01 1150243,62 1513299,11 1234452,84 1421618,76 1504004,67 1229361,63 2585062,84 1094152,60 1462108,52 Fragile X mental retardation syndrome-related protein 1 OS=Mus musculus GN=Fxr1 PE=1 SV=2 Q99JY9;Q641P0 10 10 470,17 6,93E-01 607962,15 436659,47 485020,45 581626,94 641045,63 487663,27 497514,68 404994,71 668667,07 Catenin alpha-3 OS=Mus musculus GN=Ctnna3 PE=1 SV=2 Q9JHW2 10 10 637,57 7,06E-01 1135380,57 1004449,12 1321815,91 1201254,12 1077606,33 1501215,61 1272128,25 1291049,31 1290854,32 Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Mus musculus GN=Coq9 PE=1 SV=1 O35381;Q64G17;Q9EST510 10 480,64 7,09E-01 789733,63 1112900,25 899499,18 887466,16 872179,82 772681,72 816426,38 687369,56 1006241,47 NEDD8 OS=Mus musculus GN=Nedd8 PE=1 SV=2 Q9CQ69 10 10 513,70 7,30E-01 14085488,32 13820197,53 17857030,23 14111534,37 15670923,08 13303434,02 20031576,24 16810693,07 13266794,39 AP2-associated protein kinase 1 OS=Mus musculus GN=Aak1 PE=1 SV=2 Q9R0X4;Q32MW3 12 10 516,49 7,75E-01 223319,11 190475,00 167896,26 188213,80 213085,76 171544,45 177160,47 208679,46 254519,05 Proteasome activator complex subunit 4 OS=Mus musculus GN=Psme4 PE=1 SV=1 Q9ERS2 10 10 577,86 7,86E-01 7039431,20 6804024,07 5080617,12 5552965,38 5964410,59 5017779,23 8434055,55 5136915,94 5089295,92 Acetyl-CoA acetyltransferase, mitochondrial OS=Mus musculus GN=Acat1 PE=1 SV=1 Q9Z1P6 11 10 555,34 8,59E-01 4958150,56 6237882,91 7766400,56 5557551,18 5823934,96 5891921,26 8361200,25 7374900,74 4469174,89 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Mus musculus GN=Ppp1cb PE=1 SV=3 Q99MR9 12 10 630,20 9,26E-01 62490,98 111186,83 103394,83 98310,59 87874,30 94286,63 62468,03 92294,79 97907,21 Cytospin-A OS=Mus musculus GN=Specc1l PE=1 SV=1 P62960;Q9Z2C8 12 9 956,34 2,52E-03 616151,39 743018,47 882459,26 730758,12 753213,01 839804,20 549557,59 684078,27 455916,52 Phosphoacetylglucosamine mutase OS=Mus musculus GN=Pgm3 PE=1 SV=1 Q8VCT4;Q8VCC2;Q6417612 9 689,47 1,86E-02 1603964,75 1324898,40 1534568,59 1317522,73 1313555,49 1152171,01 1203976,50 604658,83 971501,24 Myristoylated alanine-rich C-kinase OS=Mus musculus GN=Marcks PE=1 SV=2 P01029 10 9 544,35 2,00E-02 277008,95 115345,42 64594,18 290776,63 311391,96 184938,08 84491,57 122396,08 52791,58 synthase OS=Mus musculus GN=Fasn PE=1 SV=2 Q9CQH3 11 9 537,79 2,79E-02 4303272,88 4390964,95 3821420,42 2598873,95 2703110,51 2838071,50 4623469,78 3575986,83 2621202,95 Trifunctional enzyme subunit beta, mitochondrial OS=Mus musculus GN=Hadhb PE=1 SV=1 Q04447 13 9 848,36 3,52E-02 1543475,41 1603043,38 1600145,46 1854517,22 1811462,39 1850128,92 968583,14 868228,77 1403642,57 Microtubule-associated protein tau OS=Mus musculus GN=Mapt PE=1 SV=3 Q61702 10 9 681,55 3,62E-02 379159,51 160373,95 208540,53 418803,08 328696,46 299333,05 492088,94 242002,32 345939,83 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Mus musculus GN=Sdhb PE=1 SV=1 P97371 9 9 445,32 4,45E-02 729621,49 801439,05 818067,17 621885,24 676077,67 726547,34 781815,86 837202,62 740949,59 Tumor necrosis factor alpha-induced protein 8 OS=Mus musculus GN=Tnfaip8 PE=1 SV=1 O35678 9 9 389,15 4,80E-02 298024,77 349364,52 256169,41 481405,26 646749,66 563215,07 336732,76 532090,74 805401,57 5-oxoprolinase OS=Mus musculus GN=Oplah PE=1 SV=1 Q9CQ60 9 9 478,18 5,52E-02 685098,74 749721,83 509414,50 902551,72 653156,65 1194322,58 873639,63 636795,54 1226315,47 Sorcin OS=Mus musculus GN=Sri PE=1 SV=1 Q9R062 10 9 499,68 6,24E-02 1657389,63 1656613,98 2348989,68 2391521,94 2060955,59 2757615,56 2485321,52 2461963,68 2738780,82 Mitochondrial import receptor subunit TOM40 homolog OS=Mus musculus GN=Tomm40 PE=1 SV=3 P10637 10 9 448,52 6,85E-02 283766,84 327755,15 226205,11 271749,33 275290,11 236111,55 185658,30 151770,62 224799,14 Fatty acid-binding protein, heart OS=Mus musculus GN=Fabp3 PE=1 SV=5 Q8K010 9 9 436,71 6,96E-02 78648,14 54378,16 79418,62 96601,84 130147,34 77492,93 81156,76 114630,45 122707,79 ADP-ribosylation factor-like protein 1 OS=Mus musculus GN=Arl1 PE=1 SV=1 P62908 10 9 437,37 7,19E-02 780141,95 1098952,06 858297,40 678610,56 805065,11 700654,95 900323,53 502917,39 571628,72 -like protein 1 OS=Mus musculus GN=Hpcal1 PE=1 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P63330 10 9 556,69 7,31E-02 1175098,51 1109977,78 1067673,78 932892,50 980223,52 945768,60 1129329,13 809390,01 921939,97 40S ribosomal protein S26 OS=Mus musculus GN=Rps26 PE=1 SV=3 P01837 12 9 850,88 7,59E-02 6531599,03 7097733,29 1468324,01 1750130,80 785936,51 1214682,13 5612011,39 3045881,42 2114263,15 TBC1 domain family member 4 OS=Mus musculus GN=Tbc1d4 PE=1 SV=2 P04117;O08716 11 9 1033,44 8,12E-02 17685672,18 16416975,80 17528084,21 20082339,99 13604366,71 14220754,69 17399369,06 31055159,49 23131264,82 Decorin OS=Mus musculus GN=Dcn PE=1 SV=1 Q9D819 9 9 405,62 1,03E-01 713266,95 703491,11 491655,39 604250,04 558182,69 577587,45 485125,99 286323,31 558539,57 COX assembly mitochondrial protein 2 homolog OS=Mus musculus GN=Cmc2 PE=3 SV=1 Q8VCF0 9 9 623,09 1,06E-01 340611,34 230917,01 348465,86 378537,08 475404,46 474329,67 226713,60 278777,70 391234,97 Ig kappa chain V-V region MOPC 41 OS=Mus musculus GN=Gm5571 PE=1 SV=1 P01868 9 9 608,22 1,09E-01 47755568,20 33925713,68 3651501,66 5412826,81 2171054,59 4036865,34 24199764,97 13367421,45 5256476,58 OS=Mus musculus GN=Rps3 PE=1 SV=1 Q8BG95 13 9 767,69 1,09E-01 214867,27 287435,11 306364,90 349587,29 371011,11 328999,08 250872,81 218418,05 282451,97 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=1 SV=2 P11983 13 9 710,88 1,37E-01 299407,39 321762,75 218626,98 292293,71 333093,06 370252,24 252198,79 214107,24 284350,85 Centromere protein V OS=Mus musculus GN=Cenpv PE=1 SV=2 Q3U0B3 9 9 468,08 1,37E-01 406665,63 431839,28 301107,57 301341,21 251119,74 208014,67 347475,67 228891,98 293032,40 Actin-related protein 2 OS=Mus musculus GN=Actr2 PE=1 SV=1 P70414 9 9 383,56 1,43E-01 236732,44 332738,17 280693,60 334494,86 331111,37 435379,99 330815,17 295011,49 371356,93 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Mus musculus GN=Ppp2ca PE=1 SV=1 P63101 16 9 987,50 1,51E-01 3410707,63 3633904,96 2951762,67 2722632,29 2866883,77 3504351,06 3391669,19 2831558,86 3031695,87 Alpha-soluble NSF attachment protein OS=Mus musculus GN=Napa PE=1 SV=1 Q9DC61 9 9 420,43 1,56E-01 339085,23 447762,91 316410,57 417375,78 415491,06 448394,17 302098,67 278323,87 488520,48 Ig heavy chain V region MOPC 21 (Fragment) OS=Mus musculus PE=1 SV=1 P62196 10 9 473,64 1,64E-01 270095,85 255484,98 335577,55 302715,41 340655,11 307745,20 414048,87 351602,44 344176,61 39S ribosomal protein L17, mitochondrial OS=Mus musculus GN=Mrpl17 PE=1 SV=1 P27612 9 9 495,67 1,67E-01 122322,79 96006,34 83335,26 120448,59 142529,85 128975,42 102540,70 88695,68 119031,89 Striated muscle-specific serine/threonine-protein kinase OS=Mus musculus GN=Speg PE=1 SV=2 P80313 10 9 441,85 1,74E-01 374318,86 335330,98 353297,04 388193,57 320847,34 505633,25 362519,71 304439,07 441451,96 Prothymosin alpha OS=Mus musculus GN=Ptma PE=1 SV=2 Q91YP0 10 9 529,75 1,87E-01 274109,93 362568,59 309022,85 370954,00 507801,60 421857,30 327181,46 277300,03 475632,08 Fructose-2,6-bisphosphatase TIGAR OS=Mus musculus GN=Tigar PE=1 SV=1 P26231 14 9 785,71 2,03E-01 208133,70 221672,73 265358,39 296011,13 238354,07 345040,57 215980,76 276847,37 285965,44 Histone-binding protein RBBP7 OS=Mus musculus GN=Rbbp7 PE=1 SV=1 P63028 9 9 621,48 2,13E-01 3531018,60 4255292,16 2645606,01 2205937,72 2281636,82 3053484,29 4092973,54 2525685,36 3362437,59 39S ribosomal protein L1, mitochondrial OS=Mus musculus GN=Mrpl1 PE=1 SV=2 Q9DBP5 9 9 523,57 2,24E-01 704102,75 838972,96 598265,55 804244,00 723471,90 743932,15 926912,44 602484,56 785839,46 Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 Q9WVL0 9 9 618,28 2,36E-01 3289525,74 1237490,27 1671490,28 1356980,85 850640,39 731983,96 2455981,87 718037,59 808371,30 S-acyl thioesterase, medium chain OS=Mus musculus GN=Olah PE=2 SV=1 Q64010 9 9 363,46 2,54E-01 291579,79 250351,91 301189,22 386136,70 348289,81 386516,10 309814,39 328952,14 419892,72 Serotransferrin OS=Mus musculus GN=Tf PE=1 SV=1 Q9CZ44 9 9 588,98 2,70E-01 389401,67 512085,61 343379,18 390883,74 343282,95 409348,93 546880,88 435803,65 444465,24 Vesicle-fusing ATPase OS=Mus musculus GN=Nsf PE=1 SV=2 Q8CDN6 10 9 557,52 2,73E-01 620822,11 664216,38 730187,40 702440,09 632066,94 723458,48 774281,63 571696,02 833002,97 NEDD8-conjugating enzyme Ubc12 OS=Mus musculus GN=Ube2m PE=1 SV=1 P13634 10 9 632,45 2,77E-01 3738901,25 2506752,05 679728,81 628532,30 810352,72 311539,38 2480942,93 626128,77 602280,58 Ig kappa chain C region OS=Mus musculus PE=1 SV=1 P63030 9 9 677,92 3,23E-01 6153027,75 7449668,50 3757996,68 3962149,35 3667009,23 6548241,80 6741719,56 7659650,02 6415568,43 L- B chain OS=Mus musculus GN=Ldhb PE=1 SV=2 O35887 9 9 459,53 3,51E-01 493330,73 448435,53 313887,59 365669,05 387095,44 323489,32 375414,09 404636,66 263752,95 60S ribosomal protein L18a OS=Mus musculus GN=Rpl18a PE=1 SV=1 Q9D6J6 11 9 940,76 3,54E-01 10165806,43 10190106,89 9305236,72 8492261,51 9062716,57 7911795,00 11958833,30 6760479,40 8067720,33 Glycogen synthase kinase-3 beta OS=Mus musculus GN=Gsk3b PE=1 SV=2 Q9D6Y9 12 9 486,19 3,56E-01 970982,48 626625,53 970963,62 1059708,82 1152624,28 1283789,89 734742,35 514462,38 1439416,20 protein 5 OS=Mus musculus GN=Pdcd5 PE=1 SV=3 Q9QYB1;Q8BHB9 11 9 731,43 3,60E-01 1242284,41 972088,10 1531149,27 1619776,13 1460673,27 1455208,08 1017753,46 995029,84 1945978,09 OS=Mus musculus GN=Rpl7 PE=1 SV=2 P55264 9 9 482,90 3,76E-01 1126178,53 1890886,81 1986138,91 1291918,69 1377966,46 1005669,86 1772745,81 2335204,94 1404918,37 Cofilin-2 OS=Mus musculus GN=Cfl2 PE=1 SV=1 Q8VEK3 11 9 580,06 3,86E-01 520786,30 459655,51 695882,62 685205,41 709784,14 612771,48 534298,81 534197,05 791630,26 Tubulin alpha-8 chain OS=Mus musculus GN=Tuba8 PE=1 SV=1 P48722 11 9 475,27 4,01E-01 154304,19 100748,79 120342,39 138292,24 104017,78 150164,54 169244,25 80834,87 142119,08 OS=Mus musculus GN=Dst PE=1 SV=2 Q6PIE5;Q9WV27 32 9 1929,01 4,07E-01 277975,00 296608,76 659461,22 357142,80 532770,48 332338,09 451327,18 363511,48 323993,67 --tRNA ligase, cytoplasmic OS=Mus musculus GN=Nars PE=1 SV=2 Q9CPQ1 9 9 421,61 4,08E-01 6634312,77 5783601,22 6056624,96 4741494,00 5857150,55 2658734,21 10103416,48 5968744,94 4020462,27 Protein PTHB1 OS=Mus musculus GN=Bbs9 PE=1 SV=2 Q9D880 9 9 487,23 4,27E-01 546973,49 540966,92 429721,74 532435,62 576791,01 524591,30 368831,42 456712,76 536297,29 Secernin-2 OS=Mus musculus GN=Scrn2 PE=1 SV=1 Q924M7 9 9 632,23 4,34E-01 1294191,72 1636141,13 1990612,67 1868005,67 1665678,13 1837772,71 897314,73 1459609,76 1771108,70 Heterogeneous nuclear ribonucleoprotein A1 OS=Mus musculus GN=Hnrnpa1 PE=1 SV=2 Q61171 12 9 779,92 4,41E-01 22913936,96 23260329,43 10776474,24 12557662,08 12891313,87 11876375,78 26254645,88 15444819,74 13804989,09 RNA-binding protein 39 OS=Mus musculus GN=Rbm39 PE=1 SV=2 Q9DCD0 10 9 525,85 4,74E-01 503884,09 620277,05 514187,24 506764,42 480048,77 589634,52 705379,91 533338,10 579148,91 40S ribosomal protein S23 OS=Mus musculus GN=Rps23 PE=1 SV=3 P08226 10 9 674,25 4,89E-01 1961194,15 995465,80 612979,57 938416,31 690389,47 275405,36 1488898,33 552731,27 494043,38 Influenza virus NS1A-binding protein homolog OS=Mus musculus GN=Ivns1abp PE=1 SV=2 Q9WUZ7 9 9 1036,59 5,26E-01 1138147,71 979026,65 1111925,16 1259550,32 1086490,61 1334281,89 1116750,59 1002372,72 1247529,68 Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Mus musculus GN=Isca2 PE=1 SV=2 Q6P3A8 9 9 464,43 5,81E-01 912404,92 1147434,60 563728,42 771104,16 778622,55 712237,75 1119612,48 654584,29 769742,47 Putative protein PTGES3L OS=Mus musculus GN=Ptges3l PE=2 SV=1 O09111 9 9 642,52 5,86E-01 6840169,24 6187369,39 7351622,40 5485951,96 6458833,42 5963637,68 11698940,18 8435229,11 4680694,93 DNA-binding protein SMUBP-2 OS=Mus musculus GN=Ighmbp2 PE=1 SV=1 A2AQ07 12 9 673,18 5,87E-01 174722,17 125229,91 28592,52 65329,62 92911,68 258291,78 181123,18 52531,42 50577,56 Fatty acid-binding protein, adipocyte OS=Mus musculus GN=Fabp4 PE=1 SV=3 Q60714 10 9 546,61 5,94E-01 444362,28 426125,58 359935,54 381899,95 376548,46 363905,33 450985,22 440230,42 425483,39 Nexilin OS=Mus musculus GN=Nexn PE=1 SV=3 Q61234 9 9 550,23 6,22E-01 214440,98 333652,79 462051,07 406411,17 372236,57 477907,74 387366,70 385661,44 408096,35 LIM and calponin domains-containing protein 1 OS=Mus musculus GN=Limch1 PE=1 SV=2 Q8R146 9 9 405,93 6,26E-01 520791,73 584976,55 206893,38 319442,94 298327,82 351672,16 629747,44 238813,59 312094,13 Xin actin-binding repeat-containing protein 1 OS=Mus musculus GN=Xirp1 PE=1 SV=2 Q3U1J4 10 9 457,43 6,58E-01 65892,57 63314,62 138195,52 111869,84 102031,71 116602,68 96505,41 63310,55 142453,93 FYVE and coiled-coil domain-containing protein 1 OS=Mus musculus GN=Fyco1 PE=1 SV=1 Q9WTP6 9 9 611,64 6,63E-01 2636192,25 2554200,82 2684044,76 2559270,37 3043936,22 3014620,02 2828574,05 3011608,20 3014010,06 Kynurenine--oxoglutarate transaminase 1 OS=Mus musculus GN=Ccbl1 PE=1 SV=1 Q7TQI3 9 9 497,13 7,32E-01 381484,93 382648,43 482608,97 531776,20 451204,91 377832,99 400380,17 495032,37 506596,31 Glutamate receptor ionotropic, kainate 4 OS=Mus musculus GN=Grik4 PE=2 SV=2 O88746 9 9 531,88 7,46E-01 319645,67 143040,10 335855,00 295944,46 306282,59 303469,56 283253,10 251595,29 454767,76 Nuclear transport factor 2 OS=Mus musculus GN=Nutf2 PE=1 SV=1 P00405 11 9 715,25 7,52E-01 15231988,14 14134184,60 16750015,26 13710447,95 20372015,68 13386471,93 29632231,48 18042919,36 12519372,49 Carboxymethylenebutenolidase homolog OS=Mus musculus GN=Cmbl PE=1 SV=1 Q8CG76 9 9 550,93 7,79E-01 1175589,39 1005716,47 970590,11 1117290,91 1083944,83 1166636,11 630277,47 710894,47 1520913,15 CAP-Gly domain-containing linker protein 1 OS=Mus musculus GN=Clip1 PE=1 SV=1 O70325;Q91XR9 11 9 476,45 8,06E-01 942743,79 840417,07 586602,09 535074,38 862401,78 594478,80 810433,90 647320,32 553658,31 2 OS=Mus musculus GN=Pgam2 PE=1 SV=3 Q9CPP6 10 9 804,44 8,38E-01 7502772,18 7503891,19 9275141,90 7117487,89 8634494,18 8464982,01 10019542,23 8400167,07 7330868,18 Protein FAM210A OS=Mus musculus GN=Fam210a PE=1 SV=1 Q8R0N6 9 9 412,20 8,68E-01 465440,76 649892,17 601374,49 502542,44 577787,98 472912,25 454322,76 494996,61 717101,97 Serum albumin OS=Mus musculus GN=Alb PE=1 SV=3 P46471 10 9 480,58 9,74E-01 337307,49 353505,12 295068,92 368676,03 332448,26 312350,18 391360,36 300513,06 364392,22 Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Mus musculus GN=C1qbp PE=1 SV=1 Q99KC8 9 9 367,69 9,74E-01 195905,22 170971,64 222566,75 215630,63 174498,92 239616,10 172740,31 167518,44 248268,45 Eukaryotic translation initiation factor 3 subunit I OS=Mus musculus GN=Eif3i PE=1 SV=1 Q80XL6 8 8 340,47 4,06E-03 90646,59 64125,24 101743,99 132630,10 166717,43 125398,66 149660,84 196185,62 177224,41 Mitochondrial import inner membrane translocase subunit Tim21 OS=Mus musculus GN=Timm21 PE=1 SV=1 P01867 8 8 477,02 4,35E-03 2865004,47 831420,96 1494480,58 799216,73 298001,47 994574,49 1491070,92 1246677,60 1225626,56 WD repeat-containing protein 37 OS=Mus musculus GN=Wdr37 PE=1 SV=1 P04186 8 8 390,58 6,34E-03 407356,69 281764,59 210806,50 269793,75 378724,20 260454,79 191010,29 125580,19 191111,82 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Mus musculus GN=Sdhc PE=1 SV=1 Q3UM45 9 8 588,77 1,18E-02 190217,90 208580,68 236874,37 185183,21 176091,33 187825,48 208918,54 193036,22 197310,43 Cytochrome b OS=Mus musculus GN=Mt-Cyb PE=1 SV=1 Q9WTR5 8 8 398,14 1,21E-02 1189379,14 1331634,54 1202341,90 921155,69 1161833,05 1087826,59 836740,13 1176029,22 709995,92 Reticulon-2 OS=Mus musculus GN=Rtn2 PE=1 SV=1 Q9DCJ5 8 8 533,79 1,53E-02 5262621,98 5081605,70 5959118,69 3595881,01 3876614,52 3434863,71 4392876,15 4443180,42 2556845,34 GTPase NRas OS=Mus musculus GN=Nras PE=1 SV=1 Q6R0H7;P63094 10 8 374,76 2,05E-02 367649,18 342076,56 456885,79 488210,38 451529,80 587533,47 460414,62 624479,78 583680,71 28S ribosomal protein S18c, mitochondrial OS=Mus musculus GN=Mrps18c PE=1 SV=1 Q9D023 8 8 496,54 2,46E-02 8839458,74 10074338,63 6434584,03 5446734,93 6677506,39 6078279,72 6516707,73 6862311,95 5407318,88 Ig kappa chain V-V region HP R16.7 OS=Mus musculus PE=1 SV=1 Q3V384 8 8 399,84 2,78E-02 161519,86 174159,74 219308,01 339244,87 287211,65 281605,89 161929,31 197124,11 240308,34 Gamma-enolase OS=Mus musculus GN=Eno2 PE=1 SV=2 Q8C7H1 8 8 329,73 2,98E-02 67014,81 105260,33 87825,45 151110,40 149004,49 164622,23 90558,71 81282,66 149028,92 ATP synthase protein 8 OS=Mus musculus GN=Mtatp8 PE=1 SV=1 P68037 9 8 502,50 3,93E-02 1588354,07 1656647,33 1508167,88 1714961,88 1762321,35 1762811,13 1327410,20 1268397,79 1837792,12 Calcium-binding protein 39 OS=Mus musculus GN=Cab39 PE=1 SV=2 P63242;Q8BGY2 9 8 592,45 4,64E-02 1019924,72 1397394,17 1807415,57 2016541,30 1663434,83 1982367,22 1840570,14 1916075,87 2149084,12 39S ribosomal protein L23, mitochondrial OS=Mus musculus GN=Mrpl23 PE=1 SV=1 P62983;P0CG49 8 8 415,20 4,94E-02 21702507,89 16065260,32 9452982,22 9377280,40 6613533,55 5707845,82 11104370,80 5526045,47 5359077,16 Alpha/beta hydrolase domain-containing protein 14B OS=Mus musculus GN=Abhd14b PE=1 SV=1 P62962 9 8 518,82 5,56E-02 3552520,94 3913239,76 4033385,76 4623324,70 5099088,98 5095360,43 3336100,43 3406352,98 5256678,68 GDP-L-fucose synthase OS=Mus musculus GN=Tsta3 PE=1 SV=3 P46935 8 8 424,56 5,57E-02 52192,91 76568,49 87998,02 108949,95 95334,19 136576,11 88500,11 109250,57 129148,60 NADP-dependent malic enzyme OS=Mus musculus GN=Me1 PE=1 SV=2 O35350 9 8 327,97 6,19E-02 122558,86 183798,21 103280,29 118156,14 134203,09 106600,16 94998,33 65994,83 102123,90 UTP--glucose-1-phosphate uridylyltransferase OS=Mus musculus GN=Ugp2 PE=1 SV=3 Q8BVI4 9 8 566,90 8,74E-02 1065159,05 965750,63 1058662,62 1115536,01 1002944,57 1088534,85 913952,02 741888,10 1056602,16 Dihydropteridine reductase OS=Mus musculus GN=Qdpr PE=1 SV=2 Q9DBC7 8 8 397,26 9,33E-02 927515,15 819552,80 879075,22 1047723,90 1216508,15 1007262,99 627793,27 694656,15 1171161,84 Kelch-like protein 41 OS=Mus musculus GN=Klhl41 PE=1 SV=1 Q925I1 8 8 428,91 9,85E-02 337891,93 512248,94 476883,51 456466,25 538615,34 434798,72 433297,34 486453,92 422390,34 28S ribosomal protein S2, mitochondrial OS=Mus musculus GN=Mrps2 PE=1 SV=1 O08788 9 8 555,85 1,08E-01 83550,75 85501,40 102235,17 101123,41 120171,39 104552,25 69436,53 72209,15 97145,14 Carboxylesterase 1C OS=Mus musculus GN=Ces1c PE=1 SV=4 P60335 11 8 618,54 1,09E-01 977127,98 1060642,65 1124041,50 958465,98 977905,74 1038215,22 781903,30 768177,46 1044885,22 Perilipin-5 OS=Mus musculus GN=Plin5 PE=1 SV=1 Q06185 8 8 498,46 1,14E-01 9044475,87 8753719,00 11502430,46 9514304,06 11887134,48 12131008,15 13622495,40 16549175,87 10284536,10 Dual specificity mitogen-activated protein kinase kinase 1 OS=Mus musculus GN=Map2k1 PE=1 SV=2 P20918;P83714 10 8 366,52 1,35E-01 508438,33 209374,82 239550,91 291922,06 308579,68 210341,46 244989,69 193298,68 173587,98 Ubiquitin-conjugating enzyme E2 variant 2 OS=Mus musculus GN=Ube2v2 PE=1 SV=4 P21981 9 8 497,33 1,52E-01 441839,40 333369,28 173639,34 336161,53 183699,19 343566,84 237110,08 222829,64 246789,84 cleavage system H protein, mitochondrial OS=Mus musculus GN=Gcsh PE=1 SV=2 P22315 8 8 555,21 1,58E-01 485552,18 300229,84 394220,95 294706,95 531384,86 433321,56 381768,30 494731,72 494415,53 Transport and Golgi organization 2 homolog OS=Mus musculus GN=Tango2 PE=1 SV=1 E9Q4Z2 11 8 320,98 1,73E-01 51808,69 138890,52 136922,48 42204,25 115133,31 69511,18 69913,41 60405,31 63661,23 ATP-dependent 6-, liver type OS=Mus musculus GN=Pfkl PE=1 SV=4 Q99KJ8 8 8 601,19 1,79E-01 753938,09 722278,93 705868,33 639498,87 812696,24 646772,31 665360,49 570804,63 766393,59 Glycogen [starch] synthase, muscle OS=Mus musculus GN=Gys1 PE=1 SV=2 Q9DCL9 11 8 552,91 2,16E-01 351017,44 368897,76 257671,02 395586,21 384830,58 443517,00 290664,52 348276,89 332592,56 39S ribosomal protein L21, mitochondrial OS=Mus musculus GN=Mrpl21 PE=1 SV=1 Q9DCV4 9 8 504,80 2,27E-01 758740,43 912256,08 623203,02 907464,67 845586,34 786397,76 943669,71 1000845,68 821677,11 COP9 signalosome complex subunit 3 OS=Mus musculus GN=Cops3 PE=1 SV=3 P14094 10 8 468,94 2,46E-01 2220094,00 2535557,85 2830394,10 2430842,43 2869999,71 2837152,42 3081299,18 2613692,37 2399386,07 Solute carrier family 2, facilitated glucose transporter member 4 OS=Mus musculus GN=Slc2a4 PE=1 SV=3 Q08857 9 8 539,63 2,53E-01 7787018,08 8597410,80 6021762,39 7627188,29 7131392,21 6771062,11 7724540,75 8542795,29 8211499,69 cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Mus musculus GN=Prkar1a PE=1 SV=3 P10126 18 8 1038,09 2,54E-01 3300770,25 2894827,82 2244847,66 2352078,75 2482292,59 1781926,58 2597381,53 1757016,31 3106397,32 Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Mus musculus GN=Nqo2 PE=1 SV=3 Q9WV35 9 8 555,96 2,61E-01 1884200,29 1782900,32 2301708,78 2403705,19 1699959,88 3122977,96 1866953,21 2048919,00 3065310,61 Glyoxalase domain-containing protein 4 OS=Mus musculus GN=Glod4 PE=1 SV=1 Q9JKB1;P58321 9 8 469,51 2,91E-01 779509,24 696182,70 538111,62 704993,11 673665,85 666517,51 662357,98 519604,48 854600,21 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=1 SV=1 Q6ZQ73 8 8 361,38 2,98E-01 281909,31 241381,70 169453,45 280501,12 306116,06 296112,33 289543,70 229841,61 349169,90 cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Mus musculus GN=Prkar2a PE=1 SV=2 P03911 8 8 449,27 2,99E-01 2195988,60 1261028,58 2408199,89 1837841,81 1030873,95 1613220,19 2862937,99 2602868,05 1491823,00 Peptidyl-prolyl cis-trans isomerase A OS=Mus musculus GN=Ppia PE=1 SV=2 Q99LB2 11 8 593,67 3,15E-01 2700879,81 2854773,10 2493250,00 2269648,42 3064293,75 2013047,48 3005653,43 2931936,95 2650479,46 Stomatin-like protein 2, mitochondrial OS=Mus musculus GN=Stoml2 PE=1 SV=1 P18242 8 8 479,65 3,32E-01 3281252,61 3109089,43 3594299,79 2479463,72 4119541,63 5293966,18 4343768,84 2998888,43 4575292,09 High mobility group protein B2 OS=Mus musculus GN=Hmgb2 PE=1 SV=3 P49222 9 8 618,03 3,45E-01 362781,66 308887,88 31298,67 32471,81 32735,88 15273,82 553963,97 47385,56 20558,57 Dynamin-1-like protein OS=Mus musculus GN=Dnm1l PE=1 SV=2 P40124 9 8 502,79 3,46E-01 493715,40 421793,59 324496,59 248897,41 312548,24 605952,21 405214,48 388737,29 273365,82 Pre-B-cell leukemia factor-interacting protein 1 OS=Mus musculus GN=Pbxip1 PE=1 SV=2 P23116 10 8 343,96 3,49E-01 111446,95 124887,12 142057,43 107532,05 101449,60 144280,28 127435,30 107042,42 120023,47 Alpha-2-antiplasmin OS=Mus musculus GN=Serpinf2 PE=1 SV=1 Q9CQM9 8 8 408,56 3,66E-01 482451,28 411737,74 410283,63 508088,01 452044,98 591973,71 595017,41 345464,00 434999,43 26S proteasome non-ATPase regulatory subunit 3 OS=Mus musculus GN=Psmd3 PE=1 SV=3

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q9QUM0 8 8 522,75 3,68E-01 80042,65 54366,83 4462,37 14860,34 36883,44 169542,24 59602,22 45471,28 11595,05 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O OS=Mus musculus GN=Ube2o PE=1 SV=3 Q05816 9 8 497,42 3,70E-01 348487,68 336424,30 323103,23 435850,09 284340,73 267433,15 391301,20 411702,70 473208,39 ATPase family AAA domain-containing protein 3 OS=Mus musculus GN=Atad3 PE=1 SV=1 Q8CGY6 8 8 354,01 4,00E-01 159086,64 148836,89 174338,57 187817,00 222827,58 233158,24 116181,29 121523,48 205130,35 F-box only protein 40 OS=Mus musculus GN=Fbxo40 PE=1 SV=1 Q3TXS7 12 8 507,97 4,18E-01 253550,32 295118,17 246160,73 207962,76 233485,41 264906,55 327821,11 214354,04 179989,42 Actin-like protein 6A OS=Mus musculus GN=Actl6a PE=1 SV=2 Q9CZD3 8 8 297,00 4,24E-01 404827,06 219524,92 215540,22 352545,42 286111,49 409586,24 275197,09 430540,18 496661,61 ATP-binding cassette sub-family E member 1 OS=Mus musculus GN=Abce1 PE=1 SV=1 O08756 9 8 784,99 4,26E-01 6216694,91 6214113,13 6134593,79 6702059,68 6414455,22 5561183,91 5093502,75 6601095,61 8601582,86 Radixin OS=Mus musculus GN=Rdx PE=1 SV=3 Q9D5T0 10 8 333,34 4,46E-01 446643,05 621352,09 623168,76 457664,81 455955,13 679713,85 539314,51 806018,93 423950,92 --tRNA ligase OS=Mus musculus GN=Vars PE=1 SV=1 Q8R086 8 8 422,30 4,60E-01 493222,22 525062,69 664493,02 855224,75 703146,80 902552,11 316444,00 429001,76 1111334,60 28 kDa heat- and acid-stable phosphoprotein OS=Mus musculus GN=Pdap1 PE=1 SV=1 Q62167;P16381;Q6149610 8 483,48 4,74E-01 164489,64 193498,37 121180,60 152908,25 182636,53 150948,91 136830,79 112195,30 152438,80 OS=Mus musculus GN=Ttn PE=1 SV=1 P19536 8 8 508,54 5,34E-01 20731043,27 15473260,16 18049748,42 14426660,13 17254164,76 13330434,58 40435315,66 24682709,70 11869039,28 Sorting and assembly machinery component 50 homolog OS=Mus musculus GN=Samm50 PE=1 SV=1 Q9CQ75;Q3UYK3 8 8 366,98 5,40E-01 5389593,02 5588438,66 4830387,35 4439506,61 4585814,10 4037473,86 7402113,38 5308214,50 3647244,35 Metallothionein-2 OS=Mus musculus GN=Mt2 PE=1 SV=2 Q9DCS9 8 8 677,30 5,61E-01 10163037,46 10618289,10 10945277,15 7827848,22 9429576,62 8191150,88 15039963,78 9100905,90 7304756,27 Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus GN=Map2k2 PE=1 SV=2 Q9D7B6 10 8 600,27 5,63E-01 881292,50 743466,39 517600,37 639068,23 633769,75 520721,02 517822,56 650946,38 527550,03 Inorganic OS=Mus musculus GN=Ppa1 PE=1 SV=1 Q3TLP5 9 8 508,32 5,63E-01 460910,99 990226,09 993826,09 450587,19 961924,40 1195009,22 1005266,42 383960,29 1101816,05 Corticosteroid-binding globulin OS=Mus musculus GN=Serpina6 PE=1 SV=1 P48787 13 8 879,63 5,68E-01 20050024,19 20508093,17 26961179,27 21731667,61 20680573,09 30829794,71 34302276,40 31688531,63 19772315,86 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Mus musculus GN=Itih2 PE=1 SV=1 Q8BMK4 12 8 521,74 5,71E-01 141718,40 217738,42 147701,47 189932,03 217080,03 220020,75 140347,93 196226,92 259884,83 Cytoplasmic dynein 1 light intermediate chain 1 OS=Mus musculus GN=Dync1li1 PE=1 SV=1 Q8BSY0 9 8 529,48 5,76E-01 1153702,74 1072538,06 778861,08 727789,46 971290,73 1078478,46 1137762,06 802512,52 710147,18 -9 OS=Mus musculus GN=Myh9 PE=1 SV=4 Q64514 9 8 337,98 6,04E-01 137942,09 118165,52 96499,24 101153,20 100511,07 92139,65 147136,28 92632,68 82708,05 cAMP-dependent protein kinase catalytic subunit beta OS=Mus musculus GN=Prkacb PE=1 SV=2 Q64105 11 8 842,11 6,12E-01 2207636,64 2477303,51 1829421,34 2174760,19 2147424,16 1994741,90 1606713,27 1414269,49 2650631,87 Protein ERGIC-53 OS=Mus musculus GN=Lman1 PE=1 SV=1 P08752;P20612 11 8 863,55 6,21E-01 585429,41 776565,81 1113969,66 927078,01 1091933,82 941786,65 799783,26 958185,27 1164329,86 Eukaryotic translation initiation factor 3 subunit G OS=Mus musculus GN=Eif3g PE=1 SV=2 P58771 31 8 1973,21 6,28E-01 13293393,15 16802106,27 16774382,08 11730326,10 13730334,74 12285246,77 17828817,32 17465904,35 9380566,57 Eukaryotic translation initiation factor 1 OS=Mus musculus GN=Eif1 PE=1 SV=2 Q9DCN2 8 8 429,67 6,33E-01 607447,96 740181,30 656899,85 603274,65 625125,82 632655,68 809053,70 553928,84 704500,30 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Mus musculus PE=1 SV=1 Q8BFP9 9 8 488,74 6,57E-01 445053,73 484084,71 226943,45 412068,04 598988,20 395477,90 289399,90 390947,93 493800,69 Proteasome subunit beta type-6 OS=Mus musculus GN=Psmb6 PE=1 SV=3 Q99LP6 12 8 416,35 6,75E-01 1071750,12 1325698,47 985616,16 976153,76 1096103,05 932658,78 1087070,67 990721,18 915632,59 Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadl PE=1 SV=2 Q60759 9 8 501,28 6,95E-01 755588,52 979473,61 843849,20 1026593,88 935119,14 942757,55 610214,98 828885,21 1092441,09 Mitochondrial antiviral-signaling protein OS=Mus musculus GN=Mavs PE=1 SV=1 Q9CZ30 9 8 449,80 7,29E-01 3288635,82 3392083,34 2859424,43 3112266,37 2918239,95 2736227,75 2009863,57 2530295,11 3392845,57 Mitogen-activated protein kinase 14 OS=Mus musculus GN=Mapk14 PE=1 SV=3 P50171 8 8 641,58 7,80E-01 1164925,85 1196864,94 1036633,19 1047465,22 1126995,06 856622,46 1029779,39 1032278,44 1136797,45 Protein phosphatase methylesterase 1 OS=Mus musculus GN=Ppme1 PE=1 SV=5 Q5EBG6 8 8 502,93 8,01E-01 6845214,04 4478512,67 3535163,48 3841126,82 4109551,76 4638990,45 4514474,71 4708562,22 4057711,23 28S ribosomal protein S35, mitochondrial OS=Mus musculus GN=Mrps35 PE=1 SV=2 P35505 10 8 532,46 8,27E-01 1022645,65 193871,49 160067,51 933624,18 149763,85 495770,40 588993,89 210141,03 955861,37 Saccharopine dehydrogenase-like oxidoreductase OS=Mus musculus GN=Sccpdh PE=1 SV=1 Q9CRD0 8 8 513,16 8,40E-01 405136,05 657327,97 537469,21 520354,48 623548,90 542419,38 364502,67 585880,03 529188,07 RNA-binding protein Musashi homolog 2 OS=Mus musculus GN=Msi2 PE=1 SV=1 Q9CYT6 9 8 450,90 8,74E-01 228813,17 133203,51 181074,62 131595,06 210621,81 222970,16 279696,93 174049,26 254358,06 Reticulophagy receptor Fam134b OS=Mus musculus GN=Fam134b PE=1 SV=2 Q91VT4 8 8 592,28 8,98E-01 1146907,14 998027,13 944995,25 881310,80 1223531,69 779262,89 1225495,54 847561,63 952390,09 Protein S100-A11 OS=Mus musculus GN=S100a11 PE=1 SV=1 Q9DB15 8 8 427,35 9,49E-01 745472,88 1114677,19 802229,63 971787,57 820798,52 691076,51 857809,72 735228,68 868663,32 SPRY domain-containing protein 4 OS=Mus musculus GN=Spryd4 PE=1 SV=1 Q71RI9 9 8 518,62 9,68E-01 509939,69 776308,95 751092,89 702402,64 738214,74 733654,05 519798,33 651973,48 1053064,43 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 Q9D832 7 7 384,36 1,67E-03 145809,34 167392,11 167959,95 225535,09 227532,29 240827,02 177549,05 165296,38 185388,86 m7GpppX diphosphatase OS=Mus musculus GN=Dcps PE=1 SV=1 O88587 7 7 307,21 8,42E-03 177855,54 189041,81 284134,28 447822,39 337433,58 505035,30 435418,14 750548,48 1256735,16 COP9 signalosome complex subunit 7a OS=Mus musculus GN=Cops7a PE=1 SV=2 Q6P1B1 8 7 347,30 1,11E-02 166605,26 172670,39 200542,08 270585,89 337645,08 270512,09 202422,88 201867,71 265861,08 Alpha-endosulfine OS=Mus musculus GN=Ensa PE=1 SV=1 P70168 7 7 310,63 1,11E-02 162732,45 145540,01 232859,68 324609,01 232157,35 408145,38 338501,51 220712,58 547523,81 Glycogen phosphorylase, form OS=Mus musculus GN=Pygb PE=1 SV=3 P35385 7 7 490,30 1,29E-02 1824048,46 1839332,87 1438238,49 1227846,12 1478897,29 1443900,64 956013,12 1402192,47 1190469,64 Sorting nexin-2 OS=Mus musculus GN=Snx2 PE=1 SV=2 Q61595 11 7 351,09 1,34E-02 74384,10 79435,00 116636,59 153776,08 153070,69 185011,54 113611,73 111980,03 126264,11 subunit 1 OS=Mus musculus GN=Dctn1 PE=1 SV=3 Q5M8N4 7 7 354,20 1,47E-02 451013,75 357525,83 461862,54 576318,53 846048,19 725893,17 439443,45 513358,82 711429,51 Muscle-related coiled-coil protein OS=Mus musculus GN=Murc PE=1 SV=1 Q8BGQ7 9 7 409,87 2,18E-02 86240,57 97192,50 80925,77 103933,48 118482,18 114327,63 98078,46 68829,78 131449,39 Ig kappa chain V19-17 OS=Mus musculus GN=Igk-V19-17 PE=1 SV=1 Q9D0I9 9 7 349,90 2,23E-02 135302,09 107440,35 105987,93 150766,51 155537,74 172886,67 110172,06 126246,34 162211,40 Methylmalonyl-CoA mutase, mitochondrial OS=Mus musculus GN=Mut PE=1 SV=2 Q9R0P5 10 7 540,96 2,29E-02 1748826,36 2017025,72 2229477,88 2487865,65 2449020,39 2348722,51 2224333,29 2434833,66 2497287,42 Ig gamma-1 chain C region secreted form OS=Mus musculus GN=Ighg1 PE=1 SV=1 P70695 7 7 412,85 2,89E-02 117826,79 81498,59 162589,59 184354,08 204049,80 225273,43 142566,81 454965,11 523795,38 Protein phosphatase 1 regulatory subunit 12B OS=Mus musculus GN=Ppp1r12b PE=1 SV=2 P10493 7 7 414,77 3,40E-02 227714,22 328249,44 420414,91 429514,04 457801,23 345283,47 283977,68 228858,48 339287,64 Homeobox protein cut-like 1 OS=Mus musculus GN=Cux1 PE=1 SV=3 P16045 7 7 517,20 3,47E-02 3232711,16 3124396,18 4091467,85 2848426,76 3215916,61 3575350,53 1821952,04 2530758,82 2834372,33 Poly(rC)-binding protein 1 OS=Mus musculus GN=Pcbp1 PE=1 SV=1 P52503 7 7 673,11 3,94E-02 4797861,21 4722101,28 5683000,67 3483068,50 3381053,96 3385480,17 4424936,72 4871000,16 2972920,14 Pre-mRNA-processing-splicing factor 8 OS=Mus musculus GN=Prpf8 PE=1 SV=2 Q8BLF1 7 7 474,59 4,59E-02 764892,88 881029,03 783676,70 960380,27 1181647,33 1109702,88 757746,52 1129906,78 1131579,48 Nuclear protein localization protein 4 homolog OS=Mus musculus GN=Nploc4 PE=1 SV=3 P62806 8 7 460,45 5,17E-02 11019312,06 9475514,47 9088236,26 4967244,33 5663043,82 8279983,20 9834216,79 8348574,92 4439233,21 39S ribosomal protein L10, mitochondrial OS=Mus musculus GN=Mrpl10 PE=1 SV=2 O08663 8 7 544,10 5,79E-02 87456,75 64791,54 134802,86 148278,22 102951,49 113595,72 68371,14 65136,89 151339,72 -related protein 3 OS=Mus musculus GN=Dpysl3 PE=1 SV=1 Q9DB05;P28663 7 7 345,38 7,34E-02 59141,76 53564,10 69827,51 60339,92 82898,69 89055,79 79322,27 57385,58 73249,31 Teneurin-3 OS=Mus musculus GN=Tenm3 PE=1 SV=1 Q06138;Q9DB16 8 7 286,13 8,54E-02 63756,30 79665,86 85634,12 94131,67 114728,83 98250,08 66600,60 70328,17 109389,86 Acyl-CoA dehydrogenase family member 10 OS=Mus musculus GN=Acad10 PE=1 SV=1 Q8BVZ1 7 7 335,72 8,95E-02 88427,76 31845,92 18606,91 49851,30 84195,78 37273,00 63945,39 102633,59 107257,03 Queuine tRNA-ribosyltransferase OS=Mus musculus GN=Qtrt1 PE=1 SV=2 P54797 8 7 433,71 9,13E-02 187558,06 224167,72 244646,57 368903,54 391450,71 411780,92 213145,12 280677,22 602769,08 Protein NLRC3 OS=Mus musculus GN=Nlrc3 PE=2 SV=2 P12382 12 7 659,54 9,23E-02 280659,13 360429,66 324983,40 443269,56 522419,16 509369,40 278955,49 309905,86 484937,98 Lysosome-associated membrane glycoprotein 1 OS=Mus musculus GN=Lamp1 PE=1 SV=2 Q8VDD5 16 7 755,09 1,04E-01 58873,44 49772,26 55081,19 49327,50 60980,14 67941,44 97253,77 49228,74 68579,24 28S ribosomal protein S22, mitochondrial OS=Mus musculus GN=Mrps22 PE=1 SV=1 Q8R127 8 7 335,02 1,06E-01 474057,60 526210,74 405441,26 499730,74 589264,40 643013,70 551877,75 652064,83 554190,17 Myosin light polypeptide 6 OS=Mus musculus GN=Myl6 PE=1 SV=3 A2AMM0 8 7 723,92 1,08E-01 1619336,44 1836899,50 1580364,41 2266149,38 2218394,62 2061458,11 1487642,57 1791229,47 1893578,17 Ubiquitin-like modifier-activating enzyme 1 OS=Mus musculus GN=Uba1 PE=1 SV=1 Q62188 9 7 639,03 1,10E-01 142793,38 202000,82 193520,10 224391,37 203193,38 218375,55 201207,99 182499,64 253906,49 ATP synthase subunit e, mitochondrial OS=Mus musculus GN=Atp5i PE=1 SV=2 Q9DCS3 8 7 587,75 1,14E-01 680962,06 611667,16 755550,77 910399,98 1212067,49 1140353,44 522436,58 540684,93 1029775,31 Trans-2-enoyl-CoA reductase, mitochondrial OS=Mus musculus GN=Mecr PE=1 SV=2 P09405 9 7 412,90 1,17E-01 154961,68 196799,76 242882,06 199210,50 226238,59 243695,09 266462,04 192557,69 292458,43 4-aminobutyrate aminotransferase, mitochondrial OS=Mus musculus GN=Abat PE=1 SV=1 Q99MN1 7 7 329,76 1,17E-01 313232,52 327643,39 243110,55 249761,97 238302,53 269408,79 227307,37 225714,77 266247,15 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma OS=Mus musculus GN=Agpat3 PE=1 SV=2 Q9JMH6 8 7 547,00 1,25E-01 148071,40 168261,06 150008,33 207382,80 231433,78 200523,80 115686,41 116711,61 203771,13 UV excision repair protein RAD23 homolog B OS=Mus musculus GN=Rad23b PE=1 SV=2 P51881 24 7 1769,99 1,31E-01 6549740,08 6795066,47 6236864,53 6987491,73 8113739,93 8380664,49 7228147,88 6726489,46 7638276,95 Cytosolic 5'- 3A OS=Mus musculus GN=Nt5c3a PE=1 SV=4 Q91V41 8 7 533,81 1,36E-01 759118,10 863953,14 808443,61 515157,65 770495,47 678700,16 815643,07 726759,56 572391,60 Non-histone chromosomal protein HMG-17 OS=Mus musculus GN=Hmgn2 PE=1 SV=2 Q3UV70 7 7 317,01 1,38E-01 160640,38 116928,64 110389,11 81020,74 115624,90 93295,44 114599,50 124058,55 85184,57 Actin-related protein 2/3 complex subunit 4 OS=Mus musculus GN=Arpc4 PE=1 SV=3 P20152;P11679 13 7 594,73 1,55E-01 322190,36 386955,11 322262,99 320282,48 152857,01 305849,62 265937,02 285405,04 153793,73 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=1 SV=2 P15116;P39038 7 7 480,39 1,65E-01 302073,15 269927,44 270836,41 419537,70 453874,10 570686,95 195749,67 269656,90 469532,97 Nucleolin OS=Mus musculus GN=Ncl PE=1 SV=2 P61982;O70456 15 7 996,11 1,65E-01 2892851,02 3065337,26 2073461,30 3784798,57 2442619,85 3894908,87 2804894,28 4728641,47 4407032,81 --tRNA ligase OS=Mus musculus GN=Kars PE=1 SV=1 P28474;Q64437 8 7 558,82 1,75E-01 1516649,25 1225623,25 1856928,76 1803858,09 1648088,18 1633524,01 1102237,22 1239980,99 1669104,92 Proteasome activator complex subunit 2 OS=Mus musculus GN=Psme2 PE=1 SV=4 Q9Z2W0 8 7 393,79 1,76E-01 553520,07 485639,60 598113,40 791207,21 849607,63 741289,56 641455,72 503477,70 897949,79 Thioredoxin, mitochondrial OS=Mus musculus GN=Txn2 PE=1 SV=1 Q9CRB8 7 7 320,21 1,86E-01 605735,46 582739,33 930337,02 892746,99 879244,95 669164,49 1123707,39 984268,66 737111,07 Glucosidase 2 subunit beta OS=Mus musculus GN=Prkcsh PE=1 SV=1 Q3UZA1 7 7 268,56 1,89E-01 137901,86 147104,92 221545,37 187858,61 207830,64 204904,62 217980,26 205650,53 247338,61 Mitochondrial protein 1 OS=Mus musculus GN=Trmt10c PE=1 SV=2 P07309 7 7 582,56 2,19E-01 8154838,12 3834299,40 4681121,42 2652201,99 3322553,73 3006808,17 7559694,16 1461442,77 3018738,06 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Suclg2 PE=1 SV=3 Q9DC07 7 7 395,70 2,19E-01 715547,47 727174,83 990601,22 963646,06 945054,16 1162596,97 965283,96 1065233,37 661266,48 ER membrane protein complex subunit 1 OS=Mus musculus GN=Emc1 PE=1 SV=1 P21614 8 7 361,06 2,32E-01 1227207,63 851044,70 714601,80 517140,42 700430,50 438250,98 1229092,46 452896,26 522998,41 Stress-induced-phosphoprotein 1 OS=Mus musculus GN=Stip1 PE=1 SV=1 O35639 9 7 483,57 2,35E-01 124027,17 166041,40 209066,04 248491,89 195068,27 182752,32 146539,83 158663,78 236763,41 Cold shock domain-containing protein C2 OS=Mus musculus GN=Csdc2 PE=1 SV=2 Q02819 8 7 377,47 2,41E-01 84298,06 119215,71 81467,91 94426,22 123260,30 101475,13 74022,23 63602,70 136314,32 39S ribosomal protein L39, mitochondrial OS=Mus musculus GN=Mrpl39 PE=1 SV=4 Q8R0F8 7 7 393,43 2,51E-01 1069074,58 1322071,74 1309326,08 1410195,38 1500672,60 2077422,39 1301146,62 1068058,81 1852843,00 Large proline-rich protein BAG6 OS=Mus musculus GN=Bag6 PE=1 SV=1 P60710 25 7 2020,83 2,52E-01 11821397,20 12062126,39 10821679,42 7530031,72 11485378,92 9592250,82 15400140,71 12196143,61 7634669,60 CD81 antigen OS=Mus musculus GN=Cd81 PE=1 SV=2 Q9CXT8 9 7 523,61 2,52E-01 287296,18 193502,81 370537,04 422015,31 174104,33 532311,40 313008,13 447039,34 534428,97 Mitofusin-2 OS=Mus musculus GN=Mfn2 PE=1 SV=3 Q9DB60 7 7 463,40 2,54E-01 464361,61 334470,56 286871,04 514481,73 555059,59 642455,14 358888,76 417122,95 386348,48 Collagen alpha-1(XVIII) chain OS=Mus musculus GN=Col18a1 PE=1 SV=4 Q9DCM0 8 7 385,09 2,64E-01 897167,77 703349,30 582206,50 645165,09 641927,17 527305,34 472396,11 460365,87 628539,32 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Mus musculus GN=Gpd1 PE=1 SV=3 Q9CPQ8 7 7 459,93 3,04E-01 24419726,00 21234712,62 19554903,62 23100005,08 23874146,72 19618017,64 17431879,71 21347333,06 22644685,12 EH domain-containing protein 1 OS=Mus musculus GN=Ehd1 PE=1 SV=1 Q9D7J9 8 7 535,24 3,05E-01 510886,10 547472,97 732205,62 650203,34 608946,57 726622,20 416451,63 487403,72 789740,68 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 Q8BWB1 7 7 427,10 3,06E-01 198694,73 189436,23 223114,40 173519,62 167157,45 239089,04 156338,95 168355,37 186020,17 28S ribosomal protein S7, mitochondrial OS=Mus musculus GN=Mrps7 PE=1 SV=1 Q9QYC0 7 7 330,49 3,09E-01 57837,31 75722,05 44767,27 42871,99 49923,26 38575,33 60693,96 42958,46 35103,62 Rho GDP-dissociation inhibitor 2 OS=Mus musculus GN=Arhgdib PE=1 SV=3 P97478 8 7 540,34 3,31E-01 2264625,76 2899072,58 1479120,92 1637141,97 1718956,39 1544521,56 1586655,98 1909241,35 1494871,02 Histone H3.3C OS=Mus musculus GN=H3f3c PE=3 SV=3 Q8VDJ3 8 7 330,59 3,32E-01 339500,09 375939,86 408202,62 318359,23 378906,67 347748,28 393519,30 370664,73 399989,23 Serum amyloid A-4 protein OS=Mus musculus GN=Saa4 PE=1 SV=2 P18572 7 7 416,29 3,50E-01 2574545,51 2274115,78 2265880,01 2520220,45 2145975,79 2182656,62 2525772,09 1473254,55 2091244,88 Cardiomyopathy-associated protein 5 OS=Mus musculus GN=Cmya5 PE=1 SV=2 Q9D6U8 8 7 432,84 3,74E-01 1619989,74 1040731,27 1698024,61 1581815,59 1682499,43 1851575,11 1637050,47 1562239,47 1905997,23 Protein phosphatase 1 regulatory subunit 26 OS=Mus musculus GN=Ppp1r26 PE=2 SV=2 Q9CQ54 7 7 366,47 3,78E-01 5004492,97 5104020,47 4091469,09 3708381,73 3776114,51 3273026,28 5683957,37 4155422,93 2852652,74 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Mus musculus GN=Ndufaf4 PE=1 SV=1 Q8JZQ9 7 7 244,67 3,90E-01 730163,72 781183,67 137524,48 169785,41 152662,59 159416,12 954179,12 197806,94 171694,73 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Mus musculus GN=Ndufs4 PE=1 SV=3 Q62417 9 7 512,35 4,16E-01 38870,71 36172,85 74580,00 83152,82 70344,24 94818,57 38844,89 111242,17 62485,67 glycoprotein IX OS=Mus musculus GN=Gp9 PE=1 SV=1 P36552 7 7 317,43 4,21E-01 133211,72 157347,89 131209,56 102808,51 128131,84 108443,47 81145,09 123835,28 174232,80 1, cytoplasmic OS=Mus musculus GN=Txnrd1 PE=1 SV=3 Q9D6J5 7 7 349,80 4,33E-01 7661299,76 7537957,45 7797614,06 6220123,22 6481574,01 6240700,97 11479762,92 7639594,80 5567041,31 28S ribosomal protein S34, mitochondrial OS=Mus musculus GN=Mrps34 PE=1 SV=1 Q9QUM9 7 7 339,35 4,42E-01 849513,28 528629,82 654295,03 639365,57 347015,85 560578,87 395700,34 618405,93 454205,03 40S ribosomal protein S14 OS=Mus musculus GN=Rps14 PE=1 SV=3 Q8BG32 8 7 300,10 4,62E-01 302171,48 313404,97 280263,27 254083,51 316393,59 297037,31 291286,89 280827,91 362853,47 Histone H2A type 3 OS=Mus musculus GN=Hist3h2a PE=1 SV=3

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P62334 7 7 365,62 4,94E-01 291115,26 470523,24 358135,20 374696,99 482488,74 394460,47 512331,81 355794,78 462652,77 Histone H2A type 2-C OS=Mus musculus GN=Hist2h2ac PE=1 SV=3 O08532 7 7 363,49 4,96E-01 63505,40 59123,55 150470,08 102578,65 97777,63 133090,16 55932,03 79354,74 95022,64 Cysteine and glycine-rich protein 3 OS=Mus musculus GN=Csrp3 PE=1 SV=1 P29699 8 7 658,97 5,08E-01 6579067,60 3024659,31 3725803,86 3049119,03 2684623,31 2723617,54 7420276,12 3746892,52 2364267,86 Histone H1.4 OS=Mus musculus GN=Hist1h1e PE=1 SV=2 Q9EP69 7 7 349,85 5,09E-01 113999,82 210771,28 133846,98 197767,99 191398,61 154274,33 155113,85 168063,33 167479,64 T-complex protein 1 subunit beta OS=Mus musculus GN=Cct2 PE=1 SV=4 Q9Z2U0;Q9CWH6 7 7 386,78 5,10E-01 884020,46 797927,79 606144,80 755520,36 739733,74 673678,65 744183,59 528574,22 761433,22 Cytochrome c oxidase subunit 1 OS=Mus musculus GN=Mtco1 PE=1 SV=2 Q8K2C6 8 7 387,60 5,40E-01 632391,75 758264,90 641178,44 598373,83 606529,55 610695,20 601976,14 584004,74 811083,48 Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Mus musculus GN=Gadd45gip1 PE=1 SV=1 Q60931 10 7 503,07 5,43E-01 1532105,87 1230881,09 1854049,18 1591282,63 1906514,61 1410400,01 2367064,85 1958872,72 1499760,49 Dysferlin OS=Mus musculus GN=Dysf PE=1 SV=3 P62204;Q9D6P8 7 7 464,05 5,43E-01 3313707,46 4713498,02 3647134,57 3004633,93 3326121,28 2820447,65 5132062,92 5801549,10 2672968,41 OX-2 membrane glycoprotein OS=Mus musculus GN=Cd200 PE=1 SV=1 Q91Z53 7 7 549,31 5,57E-01 994139,80 978362,54 840928,37 1123143,18 1202928,82 1097338,44 622615,02 876000,97 1301650,13 Enoyl-CoA hydratase, mitochondrial OS=Mus musculus GN=Echs1 PE=1 SV=1 Q9CQV8 16 7 1066,91 5,89E-01 960639,77 1215604,07 1447014,76 1119197,25 1811587,17 2405235,72 1152047,39 2050783,78 2472901,98 Lysocardiolipin acyltransferase 1 OS=Mus musculus GN=Lclat1 PE=1 SV=2 P51150 7 7 301,59 5,93E-01 1444550,61 1354403,06 1062888,83 1137374,05 1340545,56 1375210,90 1513214,12 1289562,56 1423501,59 1 OS=Mus musculus GN=Pgk1 PE=1 SV=4 P42669 7 7 336,09 6,05E-01 433520,71 501217,82 501772,02 519610,99 616926,38 566477,12 647949,93 411480,69 591843,68 Protein lin-7 homolog A OS=Mus musculus GN=Lin7a PE=1 SV=2 P97823 7 7 411,72 6,06E-01 1144683,51 1298945,48 768606,27 939487,56 898811,98 832610,78 842965,31 672884,32 1001336,10 -1 OS=Mus musculus GN=Acyp1 PE=1 SV=2 Q9DCZ1;Q99L27 9 7 534,89 6,21E-01 832630,48 693845,80 879244,76 676001,04 697889,38 1220569,10 613098,52 597730,44 847356,08 GTP-binding nuclear protein OS=Mus musculus GN=Ran PE=1 SV=3 Q9DBF1 7 7 437,35 6,30E-01 163323,98 152121,96 228433,66 279338,98 185470,56 229774,00 142011,42 178493,07 242937,58 ADP/ATP translocase 2 OS=Mus musculus GN=Slc25a5 PE=1 SV=3 P09055 9 7 422,20 6,43E-01 549678,73 965882,82 574277,47 678313,42 743331,53 875824,66 368280,02 671237,32 718019,28 NADH-ubiquinone oxidoreductase chain 1 OS=Mus musculus GN=Mtnd1 PE=1 SV=3 Q9R0P3 8 7 426,70 6,77E-01 2542678,01 2940196,60 3133691,99 2777163,47 2554197,56 3070287,05 2993424,64 3210332,02 2476915,16 Bcl-2-like protein 13 OS=Mus musculus GN=Bcl2l13 PE=1 SV=2 P53702 9 7 449,43 7,33E-01 424930,51 404385,20 422086,59 395583,20 434339,52 462998,82 463043,71 462826,96 318320,77 Mitogen-activated protein kinase kinase kinase MLT OS=Mus musculus GN=Zak PE=1 SV=1 Q9D1G3 7 7 347,51 7,57E-01 184957,28 254577,40 447777,88 308179,07 322520,28 338472,35 585028,04 399006,77 180227,35 39S ribosomal protein L2, mitochondrial OS=Mus musculus GN=Mrpl2 PE=1 SV=1 Q99JI4 7 7 297,51 7,57E-01 138478,57 162279,27 152281,11 164398,94 131250,41 161066,63 191896,40 167237,32 142697,79 ATP synthase subunit gamma, mitochondrial OS=Mus musculus GN=Atp5c1 PE=1 SV=1 Q99M87 7 7 295,07 7,68E-01 231265,45 257866,26 188904,12 179106,66 278620,78 253947,49 173376,92 201269,75 242009,61 NEDD8 ultimate buster 1 OS=Mus musculus GN=Nub1 PE=1 SV=2 P82350 7 7 400,47 7,68E-01 348883,13 505284,70 524916,37 423580,33 339190,07 446031,02 384412,52 478372,77 430636,55 Protein prune homolog OS=Mus musculus GN=Prune PE=1 SV=1 Q9WTQ5 7 7 384,81 8,07E-01 12242,90 52907,80 116282,88 36497,13 39407,77 39704,05 14655,28 31840,09 65554,20 Serine/threonine-protein kinase PAK 2 OS=Mus musculus GN=Pak2 PE=1 SV=1 Q91YQ5 8 7 291,93 8,23E-01 73500,82 65506,22 109565,50 75617,61 96221,76 108975,70 98656,82 73146,87 86631,63 LYR motif-containing protein 4 OS=Mus musculus GN=Lyrm4 PE=1 SV=1 Q8K0Z7 7 7 438,40 8,55E-01 650438,15 640205,57 726979,04 777307,10 664628,50 762353,06 692123,73 592925,28 979470,77 Mitochondrial BCS1 OS=Mus musculus GN=Bcs1l PE=1 SV=1 P62192 9 7 451,52 8,64E-01 393629,64 296163,10 247986,50 271384,74 316839,96 368319,62 360948,99 266895,88 319052,29 Polypyrimidine tract-binding protein 3 OS=Mus musculus GN=Ptbp3 PE=1 SV=1 O88696 8 7 479,88 9,24E-01 1019451,87 1062204,22 1482325,51 1352288,90 1234996,28 1134038,73 755769,85 1189096,51 1352460,85 heavy chain 1 OS=Mus musculus GN=Cltc PE=1 SV=3 Q9QX60 7 7 419,75 9,48E-01 6249739,02 361565,56 418661,46 1129050,79 413122,68 1374551,59 4142526,36 337294,63 1013414,39 Adenylosuccinate OS=Mus musculus GN=Adsl PE=1 SV=2 Q9ES46 8 7 482,19 9,55E-01 481661,64 571286,51 378812,60 365051,51 531832,96 451320,36 378944,33 438621,63 475773,76 AP-2 complex subunit mu OS=Mus musculus GN=Ap2m1 PE=1 SV=1 Q8BMS4 7 7 451,78 9,85E-01 1186138,59 1302296,36 1005741,27 1101180,15 1403379,20 1060877,02 884809,61 1126725,96 1317607,39 26S proteasome non-ATPase regulatory subunit 4 OS=Mus musculus GN=Psmd4 PE=1 SV=1 P63158 9 6 413,36 1,26E-02 1447366,14 1611396,37 2128765,32 1469501,45 1079224,42 1242171,97 1439626,62 1975394,07 1575693,85 Ras-related protein Rab-10 OS=Mus musculus GN=Rab10 PE=1 SV=1 Q61704 6 6 251,78 1,27E-02 279513,02 105574,31 171023,13 623906,27 587858,84 415639,79 247144,97 409444,20 268526,97 Prostaglandin E synthase 3 OS=Mus musculus GN=Ptges3 PE=1 SV=1 P10605 6 6 302,59 1,86E-02 727961,49 804806,88 648844,87 631366,16 594809,54 625771,73 687424,78 569959,59 527671,22 Tu, mitochondrial OS=Mus musculus GN=Tufm PE=1 SV=1 Q8QZR5 10 6 458,33 2,56E-02 373610,84 511582,36 331500,52 369371,03 359453,58 292444,80 268028,52 274323,89 289069,92 Plasminogen OS=Mus musculus GN=Plg PE=1 SV=3 P53986 6 6 432,04 2,77E-02 2705381,90 2729921,37 2709347,24 2267095,48 2309040,49 2757807,44 2513244,37 2238847,72 1993906,41 Xyloside xylosyltransferase 1 OS=Mus musculus GN=Xxylt1 PE=2 SV=2 O88487 6 6 338,36 2,96E-02 97793,33 94134,97 65475,07 87004,04 109550,50 79320,11 131372,23 106304,84 98658,12 Glutamate--cysteine ligase catalytic subunit OS=Mus musculus GN=Gclc PE=1 SV=4 P70398 6 6 224,13 3,09E-02 33929,56 20349,86 33394,18 40267,85 42279,66 40508,55 24412,47 29051,72 31167,20 isoenzyme 1 OS=Mus musculus GN=Ak1 PE=1 SV=1 Q9CZW5 8 6 474,54 3,31E-02 253582,32 223601,80 230678,30 265936,40 260912,20 284882,37 208028,01 180329,10 231123,85 C-Jun-amino-terminal kinase-interacting protein 4 OS=Mus musculus GN=Spag9 PE=1 SV=2 P18760 8 6 698,93 4,07E-02 2021442,86 2339607,45 2484636,14 2524912,96 2935684,16 3667048,42 2686422,60 2650280,06 3534730,79 Ras-related protein Rab-14 OS=Mus musculus GN=Rab14 PE=1 SV=3 P03921 6 6 449,42 4,68E-02 1169133,12 1135823,22 1839867,33 1732848,73 1799368,29 2504099,78 2537288,52 2935602,35 1788802,67 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=1 SV=1 P24472;P13745 10 6 640,71 5,28E-02 3466389,79 4027552,83 3126308,35 2628276,75 3176882,73 2363526,04 2219703,49 1806351,25 2734829,87 Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Mus musculus GN=Acss1 PE=1 SV=1 P40336 7 6 334,66 5,35E-02 104819,63 128801,85 213458,00 216413,02 213819,57 250965,24 190030,42 245360,89 233778,87 T-complex protein 1 subunit alpha OS=Mus musculus GN=Tcp1 PE=1 SV=3 Q8BP47 6 6 184,36 7,82E-02 133603,00 171683,69 84420,39 144570,07 145925,94 132441,98 119285,97 115419,71 166300,92 Dehydrogenase/reductase SDR family member 11 OS=Mus musculus GN=Dhrs11 PE=1 SV=1 Q7TPW1 7 6 285,31 8,16E-02 171664,65 228569,28 97264,91 120372,92 94693,72 171175,25 75137,87 113970,59 73688,50 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Mus musculus GN=Pcmt1 PE=1 SV=3 Q8BTY1 7 6 364,97 8,19E-02 679642,36 713074,66 971656,05 942685,89 771058,74 519789,17 420259,63 443070,53 679506,12 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Mus musculus GN=Pdp1 PE=1 SV=1 Q9CZB0 6 6 337,16 8,40E-02 5559266,49 8071320,82 6456224,76 5720027,48 6453516,26 4824621,43 6598550,42 9405200,21 4207928,75 Ribonuclease UK114 OS=Mus musculus GN=Hrsp12 PE=1 SV=3 P00158 6 6 249,75 8,43E-02 753627,28 650321,66 721732,71 857638,96 1033574,40 1128102,74 1244421,26 1082373,94 757172,62 Fumarylacetoacetate hydrolase domain-containing protein 2A OS=Mus musculus GN=Fahd2 PE=1 SV=1 P06801 7 6 407,15 8,61E-02 146438,39 125587,48 157920,41 147975,17 149191,94 222831,08 122193,27 175886,34 277694,05 Endothelial cell-selective adhesion molecule OS=Mus musculus GN=Esam PE=1 SV=1 A2AUC9 8 6 399,49 8,75E-02 207052,53 175763,01 211008,39 254590,40 248238,52 257923,43 236653,82 239118,58 263614,29 Eukaryotic translation initiation factor 3 subunit L OS=Mus musculus GN=Eif3l PE=1 SV=1 O88543 6 6 291,66 9,24E-02 178170,18 150626,97 196274,71 212178,06 191250,73 233816,68 218729,56 204999,97 238763,48 Fetuin-B OS=Mus musculus GN=Fetub PE=1 SV=1 P14142 7 6 285,74 9,31E-02 235103,15 284378,39 370732,67 329731,27 343318,01 357556,15 239461,89 241788,41 260354,70 Phosphoglucomutase-2 OS=Mus musculus GN=Pgm2 PE=1 SV=1 Q99JB2 6 6 349,75 9,55E-02 56963,12 54214,71 59879,73 98319,29 91322,87 92194,69 70056,47 77899,80 126601,12 Membrane-associated progesterone receptor component 1 OS=Mus musculus GN=Pgrmc1 PE=1 SV=4 Q61247 7 6 267,15 9,68E-02 873969,28 555380,27 446641,63 594205,64 595326,48 508667,81 675526,23 412383,04 399443,88 SEC23-interacting protein OS=Mus musculus GN=Sec23ip PE=1 SV=2 P26043 21 6 905,19 1,01E-01 322822,72 328758,56 294390,83 284385,92 287655,19 266833,26 251504,14 271482,67 315849,48 -protein phosphatase non-receptor type 11 OS=Mus musculus GN=Ptpn11 PE=1 SV=2 Q3UHX2 6 6 437,26 1,01E-01 101622,82 142503,32 153494,68 128993,04 93160,88 103446,13 101068,50 87036,88 102922,80 PDZ and LIM domain protein 5 OS=Mus musculus GN=Pdlim5 PE=1 SV=4 P60670 7 6 258,56 1,10E-01 108311,35 124770,51 94714,40 137294,89 191980,28 216645,35 90548,13 107565,74 195763,29 Tubulin-folding cofactor B OS=Mus musculus GN=Tbcb PE=1 SV=2 P54728 7 6 359,98 1,15E-01 248087,84 237328,84 250197,74 240270,25 243230,07 241411,33 219039,03 212185,47 270567,63 Eukaryotic translation initiation factor 2 subunit 1 OS=Mus musculus GN=Eif2s1 PE=1 SV=3 Q70KF4 9 6 387,92 1,23E-01 88791,29 143130,33 92950,97 113426,90 94115,04 116182,83 83332,53 95333,71 66966,04 Delta-sarcoglycan OS=Mus musculus GN=Sgcd PE=1 SV=1 Q9D1H6 6 6 242,02 1,24E-01 459183,22 396041,94 475833,41 480313,62 440858,85 450425,01 494708,32 427389,03 358432,38 Complement C1q subcomponent subunit B OS=Mus musculus GN=C1qb PE=1 SV=2 Q9CZP5 7 6 410,67 1,33E-01 180780,02 235483,81 142699,03 192369,33 204378,38 156680,43 156713,74 88021,12 106009,25 Peptidyl-glycine alpha-amidating monooxygenase OS=Mus musculus GN=Pam PE=1 SV=2 Q3TC72 7 6 498,81 1,39E-01 1462087,17 1286904,26 1202776,85 1084005,01 1124754,58 994641,35 823214,15 1102797,75 1115254,56 Trifunctional purine biosynthetic protein adenosine-3 OS=Mus musculus GN=Gart PE=1 SV=3 P82347 6 6 312,40 1,42E-01 342671,84 507684,20 609769,44 591751,79 664388,82 717926,30 394415,41 650055,84 680181,92 Sodium/calcium exchanger 1 OS=Mus musculus GN=Slc8a1 PE=1 SV=1 P70349 6 6 438,32 1,49E-01 5071755,19 6677377,55 6020686,80 4324514,68 3066671,54 3920274,62 5436173,05 5140476,04 4947486,10 28S , mitochondrial OS=Mus musculus GN=Mrps6 PE=1 SV=3 Q01768 11 6 781,68 1,53E-01 25653448,49 24784735,34 25873838,99 30776454,79 23662193,21 30820221,98 25937992,91 36144982,54 34098322,28 Electron transfer subunit alpha, mitochondrial OS=Mus musculus GN=Etfa PE=1 SV=2 P58389 6 6 257,23 1,58E-01 479344,19 347106,56 256697,14 340348,46 391190,18 330536,26 316420,47 352095,84 303772,60 -3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2 Q00898 16 6 1244,80 1,69E-01 11131018,01 3739673,64 4580630,01 6387099,20 9476133,65 3861306,05 5094024,71 1168822,39 2438535,19 Plasma protease C1 inhibitor OS=Mus musculus GN=Serping1 PE=1 SV=3 P48758;Q8K354 7 6 403,23 1,72E-01 630207,54 604551,13 638562,68 592526,66 619153,13 737141,43 794797,48 545785,62 785585,05 Mitochondrial Rho GTPase 1 OS=Mus musculus GN=Rhot1 PE=1 SV=1 Q8BK64 8 6 344,20 1,73E-01 306881,63 304281,73 394442,00 334268,87 365911,36 424295,64 335347,55 245833,57 325946,08 Protein phosphatase PTC7 homolog OS=Mus musculus GN=Pptc7 PE=1 SV=1 Q9D2N4 6 6 398,06 1,94E-01 65819,79 99792,60 127846,50 166077,73 134202,77 183403,95 96931,05 157159,88 189418,76 Transcription elongation factor A protein 1 OS=Mus musculus GN=Tcea1 PE=1 SV=2 Q6ZWY9;P70696;Q645247 6 361,37 2,01E-01 8039541,82 8838198,22 9417450,20 5058689,21 6806073,60 9281205,76 6665207,10 8800705,12 4962223,39 Protein NipSnap homolog 2 OS=Mus musculus GN=Gbas PE=1 SV=1 Q62446 7 6 277,28 2,02E-01 1015573,08 1078790,49 511146,96 475004,30 516036,54 519936,55 659567,06 579282,39 579810,13 GMP synthase [glutamine-hydrolyzing] OS=Mus musculus GN=Gmps PE=1 SV=2 P46638;P62492 6 6 420,79 2,10E-01 1191385,69 1210430,09 987593,26 1113910,57 1095923,72 1027535,80 1249784,59 1345731,75 1137366,89 Uncharacterized protein C19orf52 homolog OS=Mus musculus PE=1 SV=1 Q8CAK1 7 6 474,24 2,12E-01 397989,63 331242,32 267961,52 336878,02 374834,04 357552,68 194284,29 403388,90 451070,13 Epsin-1 OS=Mus musculus GN=Epn1 PE=1 SV=3 P11352 6 6 309,90 2,26E-01 1903296,55 2422476,04 609846,04 507149,73 541284,18 511561,14 1730225,21 471927,52 604622,16 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Mus musculus GN=Samhd1 PE=1 SV=2 Q7TNG5 6 6 257,04 2,35E-01 205248,86 148070,30 184155,16 192267,21 186545,84 172173,23 126220,56 151124,92 183885,16 Cytochrome c oxidase subunit 6A2, mitochondrial OS=Mus musculus GN=Cox6a2 PE=1 SV=2 P57776 7 6 468,84 2,41E-01 1095848,73 1121487,55 1293822,00 1147000,08 1233508,89 1087155,26 1339842,88 1232183,68 1243410,14 Proteasome subunit beta type-3 OS=Mus musculus GN=Psmb3 PE=1 SV=1 Q9D0S9 6 6 414,67 2,50E-01 5675843,79 5715635,71 5019237,58 4293378,46 4586742,43 4366033,11 4318115,58 3380534,01 5443048,17 Integrin alpha-7 OS=Mus musculus GN=Itga7 PE=1 SV=3 Q9CQR4 6 6 503,06 2,51E-01 27597073,78 29785735,71 23860717,35 22602244,84 21318531,55 28324816,77 22860009,13 24391134,76 24009508,11 Inhibitor of carbonic anhydrase OS=Mus musculus GN=Ica PE=1 SV=1 Q9CQZ5;Q9CQW7 7 6 414,00 2,53E-01 6160545,29 5923156,55 7881264,42 4631886,64 4667760,11 4121866,81 7866825,49 8344479,93 3075594,41 Prothrombin OS=Mus musculus GN=F2 PE=1 SV=1 Q8CIE6 6 6 272,90 2,56E-01 93701,63 66439,00 59204,98 72683,99 96955,37 76737,75 57705,03 37555,40 66507,00 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 Q9CQZ6 6 6 302,57 2,66E-01 5118820,59 4787766,82 5428975,52 4093073,86 4080829,06 4345875,12 7531492,88 6539457,44 3896205,18 -1 OS=Mus musculus GN=Kng1 PE=1 SV=1 P32921 7 6 330,63 2,72E-01 214901,15 159456,26 190988,43 175281,51 208546,49 234376,15 107481,24 129779,96 188364,83 1 OS=Mus musculus GN=Ctsc PE=1 SV=1 Q9CZ42 6 6 353,07 2,80E-01 296816,49 392786,23 691821,19 839958,99 833065,39 924454,98 460543,65 670566,45 1115465,00 ATP-binding cassette sub-family C member 9 OS=Mus musculus GN=Abcc9 PE=1 SV=2 Q6ZQ38 7 6 345,56 2,85E-01 502493,11 524900,07 93576,80 192332,58 135912,17 164725,83 234394,94 127728,74 202108,62 E3 OS=Mus musculus GN=Tfe3 PE=1 SV=2 Q99J99 7 6 378,90 2,98E-01 561797,13 775259,56 707359,83 1035954,19 1131889,04 640395,95 1321626,23 848028,21 1083281,69 Histidine triad nucleotide-binding protein 1 OS=Mus musculus GN=Hint1 PE=1 SV=3 Q9JLT4 7 6 394,45 3,01E-01 440910,24 409984,05 422652,80 426359,24 387026,29 439796,65 502841,42 431414,75 469507,22 Casein kinase II subunit alpha OS=Mus musculus GN=Csnk2a1 PE=1 SV=2 P25444 6 6 243,65 3,11E-01 265398,43 262964,32 231942,28 236717,71 371204,44 358281,13 215314,04 215029,91 214160,99 4 OS=Mus musculus GN=Pank4 PE=1 SV=2 Q91WU5 6 6 299,44 3,13E-01 133051,66 105549,85 137798,53 159980,14 160791,53 120883,33 96841,88 121936,31 197809,63 Histone H2A.Z OS=Mus musculus GN=H2afz PE=1 SV=2 Q9D8W5 6 6 317,43 3,22E-01 174246,01 208690,21 134252,99 160167,27 162855,92 185000,49 172279,83 136517,63 167602,37 Ras GTPase-activating protein-binding protein 1 OS=Mus musculus GN=G3bp1 PE=1 SV=1 P13020 7 6 330,73 3,26E-01 489617,09 244716,41 128956,36 186854,69 197507,04 255375,47 473498,15 144116,03 187767,20 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Mus musculus GN=Ndufs2 PE=1 SV=1 P47911 6 6 253,53 3,32E-01 231025,41 228128,05 284501,01 274659,26 291887,92 386331,84 267786,90 285814,85 205424,05 Platelet-activating factor acetylhydrolase IB subunit alpha OS=Mus musculus GN=Pafah1b1 PE=1 SV=2 Q3UMF0 6 6 220,81 3,40E-01 45274,35 53163,73 60225,29 44752,86 52372,30 33115,64 34933,04 61427,78 73766,69 14-3-3 protein zeta/delta OS=Mus musculus GN=Ywhaz PE=1 SV=1 P02468 8 6 482,70 3,42E-01 112777,41 81772,53 164599,91 107214,60 139804,88 119194,73 85947,34 93107,64 121325,12 Costars family protein ABRACL OS=Mus musculus GN=Abracl PE=1 SV=1 P59325 6 6 225,09 3,44E-01 199644,63 92243,86 75042,30 93447,16 115266,65 62676,55 101389,48 64373,16 103707,23 Protein-glutamine gamma-glutamyltransferase 2 OS=Mus musculus GN=Tgm2 PE=1 SV=4 O35643 10 6 413,25 3,45E-01 158442,82 161830,91 209626,16 228477,75 190545,86 187269,40 142046,12 144331,12 261971,68 CD99 antigen-like protein 2 OS=Mus musculus GN=Cd99l2 PE=1 SV=1 Q9CY58 7 6 470,28 3,47E-01 154058,12 211899,68 288170,81 134509,26 137299,48 152677,13 220997,39 281504,72 131304,83 Nucleoside diphosphate kinase B OS=Mus musculus GN=Nme2 PE=1 SV=1 Q921F2 6 6 329,55 3,53E-01 206820,16 259856,68 253828,93 258625,14 304733,77 364400,71 200913,29 217337,77 345863,98 Estradiol 17-beta-dehydrogenase 11 OS=Mus musculus GN=Hsd17b11 PE=1 SV=1 Q02248 8 6 377,22 3,54E-01 143974,21 170908,83 114430,48 182316,26 149016,78 162615,17 120465,40 115457,09 136349,53 Phosphatidylinositol transfer protein alpha isoform OS=Mus musculus GN=Pitpna PE=1 SV=2 O55131;Q8C650 7 6 444,84 3,56E-01 166401,22 206934,58 203614,86 261577,43 226674,23 281255,78 143615,41 173739,91 256931,89 OS=Mus musculus GN=Vcl PE=1 SV=4

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q78J03 6 6 308,97 3,56E-01 342942,18 478991,97 454240,36 404998,07 250106,73 314231,55 287916,98 364916,59 355081,11 Complex I assembly factor TIMMDC1, mitochondrial OS=Mus musculus GN=Timmdc1 PE=1 SV=1 Q62523 6 6 310,69 3,60E-01 268162,54 253681,49 180743,28 191230,82 179040,15 270645,57 234254,58 136089,19 125079,80 Cytochrome c oxidase copper chaperone OS=Mus musculus GN=Cox17 PE=1 SV=2 Q9ET54 7 6 293,98 3,60E-01 119398,09 130721,67 144284,00 132854,90 93942,88 125234,21 184520,50 153639,62 104392,37 Heat shock protein HSP 90-alpha OS=Mus musculus GN=Hsp90aa1 PE=1 SV=4 Q9EPL8 6 6 226,94 3,62E-01 92030,93 92859,78 69732,54 85498,58 83252,93 73561,80 130747,31 55623,29 95127,98 Nitrilase homolog 1 OS=Mus musculus GN=Nit1 PE=1 SV=2 Q8K4F5 6 6 329,16 3,75E-01 947429,23 1142056,27 759389,18 863022,44 790775,54 816833,69 526955,64 567808,20 912368,78 Myopalladin OS=Mus musculus GN=Mypn PE=1 SV=2 Q8K4Z3 6 6 312,35 3,80E-01 981517,45 966819,94 794903,13 883763,22 924172,72 1158292,35 884176,69 686782,48 1096510,07 OS=Mus musculus GN=Vim PE=1 SV=3 Q64433 7 6 470,42 4,02E-01 18386587,95 21593072,13 14542233,51 16851937,60 14687241,37 14935506,75 13459548,73 8469174,54 19587223,86 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 Q3UIU2 8 6 329,20 4,04E-01 3419737,84 3977156,73 3700835,01 3499487,42 4077599,67 3723072,41 3365696,43 2837218,75 2940366,96 Mitochondrial-processing peptidase subunit alpha OS=Mus musculus GN=Pmpca PE=1 SV=1 O55042;Q91ZZ3 7 6 434,39 4,16E-01 952645,82 993439,74 164415,22 204659,61 168257,28 169902,60 928594,16 243945,00 179987,24 Junction OS=Mus musculus GN=Jup PE=1 SV=3 Q922D8 7 6 292,71 4,17E-01 95616,48 153195,26 51264,05 85330,36 86884,65 70450,54 142044,48 88889,85 115667,17 Trafficking protein particle complex subunit 6B OS=Mus musculus GN=Trappc6b PE=1 SV=1 Q62351 7 6 344,93 4,22E-01 98302,57 105017,86 52289,74 62830,86 77989,43 70767,81 183317,95 62766,10 61667,57 B-cell receptor-associated protein 31 OS=Mus musculus GN=Bcap31 PE=1 SV=4 P03987 6 6 249,30 4,26E-01 427541,63 146667,95 229697,86 165702,47 206709,50 77650,81 2820945,27 69976,99 150228,11 , mitochondrial OS=Mus musculus GN=Fech PE=1 SV=2 Q9CYR0 6 6 363,56 4,40E-01 544147,12 613800,62 706865,91 759462,29 641141,68 674478,43 564701,43 592548,60 683540,96 Growth -inducible transmembrane protein OS=Mus musculus GN=Ghitm PE=1 SV=1 P68510 13 6 681,62 4,46E-01 645597,63 504478,24 743776,10 632514,34 486069,84 728391,16 678606,01 800788,98 529190,39 Serine/threonine-protein phosphatase 2A activator OS=Mus musculus GN=Ppp2r4 PE=1 SV=1 P49722 6 6 360,90 4,52E-01 436927,91 408784,91 427073,13 468599,10 397950,93 482614,99 494552,43 454442,86 475723,95 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 Q8CC35 6 6 354,23 4,60E-01 96379,00 203232,36 141142,77 155470,02 154251,56 251573,36 80551,36 211105,81 119428,95 Angiotensinogen OS=Mus musculus GN=Agt PE=1 SV=1 Q9CQC7 6 6 388,65 4,86E-01 11270451,75 13038792,84 15837293,58 9151811,90 10263227,21 11314178,02 20693028,95 16821688,37 7125343,00 SH3 domain-binding -rich-like protein 3 OS=Mus musculus GN=Sh3bgrl3 PE=1 SV=1 Q3URE1 6 6 323,52 4,98E-01 252101,34 451119,55 178625,19 350528,76 345161,74 224902,28 211057,09 178508,00 309521,76 Parathymosin OS=Mus musculus GN=Ptms PE=1 SV=3 Q78ZA7 8 6 445,69 5,08E-01 1153188,09 741881,06 857706,42 1057984,13 721376,25 1026481,90 662277,52 991741,50 837099,95 Zinc-binding domain-containing protein 2 OS=Mus musculus GN=Zadh2 PE=1 SV=1 O88544 8 6 327,76 5,14E-01 140836,74 160107,84 141699,19 146066,33 137247,45 125463,45 133665,69 69974,32 148507,97 Plasma membrane calcium-transporting ATPase 1 OS=Mus musculus GN=Atp2b1 PE=1 SV=1 Q99PT1 7 6 484,87 5,36E-01 2047073,28 2204638,97 1949642,26 2109578,27 2130692,90 2019039,82 2203041,83 1931773,44 2258807,33 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 Q7M6Y3 7 6 435,36 5,37E-01 65986,65 101560,85 69194,72 109830,28 116588,92 83630,06 57904,23 78733,31 140752,51 Peptidyl-prolyl cis-trans isomerase B OS=Mus musculus GN=Ppib PE=1 SV=2 Q8R001 6 6 317,73 5,95E-01 209254,88 271363,65 283314,83 286911,87 345001,73 298252,50 209228,75 236617,63 382612,33 Transcriptional activator protein Pur-beta OS=Mus musculus GN=Purb PE=1 SV=3 Q9QZ06 6 6 233,15 6,20E-01 348396,23 279263,75 268362,92 255308,09 223936,22 304469,39 307059,23 275402,58 232485,33 Myotrophin OS=Mus musculus GN=Mtpn PE=1 SV=2 Q6P1F6;Q8BG02;Q925E7;Q6ZWR47 6 341,73 6,22E-01 121684,13 133204,36 174842,81 161314,99 154289,15 190369,04 118773,98 219987,31 171180,00 Protein MEMO1 OS=Mus musculus GN=Memo1 PE=1 SV=1 P47802 6 6 339,40 6,50E-01 468848,89 443043,84 354291,76 414664,13 413514,65 414215,21 440981,29 462583,37 435121,60 LYR motif-containing protein 5 OS=Mus musculus GN=Lyrm5 PE=1 SV=1 Q8R2G4 6 6 241,46 6,66E-01 211637,58 301554,39 453740,29 256772,62 245498,76 382986,10 314326,93 405357,02 259333,27 Cysteine and glycine-rich protein 1 OS=Mus musculus GN=Csrp1 PE=1 SV=3 Q8VEE1 6 6 313,05 6,68E-01 139639,91 139523,04 127701,60 147480,05 109259,83 111121,96 144581,66 112370,30 125824,90 Xin actin-binding repeat-containing protein 2 OS=Mus musculus GN=Xirp2 PE=1 SV=1 Q9CQ92 6 6 390,40 6,73E-01 651684,27 642981,94 499120,32 607976,69 608695,60 530659,68 482329,74 483149,99 655533,13 Heat shock protein HSP 90-beta OS=Mus musculus GN=Hsp90ab1 PE=1 SV=3 Q9JLZ3 8 6 393,46 7,25E-01 1650914,22 1533181,71 1903570,14 1700130,48 1880711,15 1542452,01 1607445,09 1631611,84 1906309,68 26S protease regulatory subunit 8 OS=Mus musculus GN=Psmc5 PE=1 SV=1 Q9D6Y7 6 6 389,69 7,27E-01 537289,04 684380,62 871800,58 878924,32 685213,37 690136,05 594269,36 830072,64 837859,69 Nucleoside diphosphate kinase A OS=Mus musculus GN=Nme1 PE=1 SV=1 P39054;Q8BZ98 6 6 176,35 7,46E-01 698225,98 649296,28 425731,33 686878,20 520132,86 493546,26 514312,67 537562,44 586050,60 ATP-binding cassette sub-family B member 10, mitochondrial OS=Mus musculus GN=Abcb10 PE=1 SV=1 Q00897 25 6 1958,75 7,49E-01 5555121,76 1932022,40 3649781,75 1835706,44 2481545,15 1822543,35 6442093,51 1687826,94 2157956,18 39S ribosomal protein L4, mitochondrial OS=Mus musculus GN=Mrpl4 PE=1 SV=1 Q9Z2Y8 6 6 390,09 7,59E-01 714436,52 1028273,60 638478,59 624000,29 768728,15 689943,00 726293,87 616211,86 829585,99 Calcium/-dependent protein kinase type II subunit delta OS=Mus musculus GN=Camk2d PE=1 SV=1 Q8BYM8 6 6 213,68 7,70E-01 92955,04 137155,91 112595,06 115306,51 92407,87 106957,09 125439,59 83035,17 110119,74 Puromycin-sensitive aminopeptidase OS=Mus musculus GN=Npepps PE=1 SV=2 O35215 6 6 301,66 7,83E-01 1890839,34 2090462,68 1874163,39 1791159,33 1518029,81 2164264,66 1252169,69 1735746,74 2068378,90 ADP/ATP translocase 1 OS=Mus musculus GN=Slc25a4 PE=1 SV=4 Q9DCZ4 9 6 426,56 8,00E-01 6531909,52 7437223,01 4990080,32 5448993,51 5665952,91 6067130,23 6615283,89 5435111,19 4667990,15 Cadherin-2 OS=Mus musculus GN=Cdh2 PE=1 SV=2 Q8CHP8 7 6 346,74 8,01E-01 373474,32 431839,03 162160,60 259103,56 244191,35 185613,56 317742,86 189633,18 217711,45 14-3-3 protein gamma OS=Mus musculus GN=Ywhag PE=1 SV=2 P70195 6 6 348,31 8,19E-01 207578,74 139122,86 198957,21 168987,56 155811,01 159391,77 185827,50 196693,12 145144,46 MICOS complex subunit Mic10 OS=Mus musculus GN=Minos1 PE=1 SV=1 Q9DCT8 6 6 369,05 8,29E-01 20360727,31 16110347,45 15903205,78 12585114,68 19609250,34 14866712,03 20226151,92 15246689,18 16760357,90 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Mus musculus GN=Mcat PE=1 SV=3 Q6PDI5 8 6 263,17 8,57E-01 34425,16 439384,58 45727,96 60744,83 69312,26 53080,76 41639,28 39549,18 95608,25 60S acidic ribosomal protein P2 OS=Mus musculus GN=Rplp2 PE=1 SV=3 P48774 8 6 402,84 8,78E-01 533413,70 646229,50 756229,49 591271,47 575744,39 546281,98 562642,85 580214,69 770617,30 Pyruvate dehydrogenase protein X component, mitochondrial OS=Mus musculus GN=Pdhx PE=1 SV=1 P97351 9 6 335,19 9,20E-01 314278,66 158682,74 312551,64 244744,23 266528,94 316131,60 236596,90 165308,78 225171,47 Uncharacterized aarF domain-containing protein kinase 1 OS=Mus musculus GN=Adck1 PE=1 SV=1 Q9JIF9 6 6 306,30 9,33E-01 88817,18 116841,21 30972,25 78104,50 66159,69 88141,91 99979,75 92376,67 31278,68 A-2-activating protein OS=Mus musculus GN=Plaa PE=1 SV=4 Q07076 8 6 394,46 9,48E-01 129158,85 160136,66 153229,81 124531,87 139172,20 180228,33 251395,95 240999,09 108445,68 Chromatin target of PRMT1 protein OS=Mus musculus GN=Chtop PE=1 SV=2 P80317;Q61390 6 6 282,23 9,48E-01 458286,39 288186,53 267635,74 308090,27 331760,99 378012,52 442680,93 251877,06 346657,74 Heat shock cognate 71 kDa protein OS=Mus musculus GN=Hspa8 PE=1 SV=1 P62270 7 6 352,91 9,54E-01 654297,71 677472,86 564059,84 532173,17 586375,22 641197,20 880204,05 515707,05 495432,30 Coiled-coil domain-containing protein 58 OS=Mus musculus GN=Ccdc58 PE=1 SV=1 P99026 5 5 388,31 2,88E-04 619643,46 548189,26 571706,19 407862,13 430644,88 372881,07 543432,18 489045,14 459292,67 Dynein light chain 2, cytoplasmic OS=Mus musculus GN=Dynll2 PE=1 SV=1 Q9CQX8 5 5 356,88 8,76E-04 2615361,19 3121305,42 3322496,01 2802405,15 3136654,41 2416560,86 2649952,35 2863530,97 2115939,37 Cytochrome c oxidase subunit 8B, mitochondrial OS=Mus musculus GN=Cox8b PE=3 SV=1 Q8BHN3 5 5 158,34 2,32E-03 59564,75 73735,24 66689,81 88471,81 80083,14 91315,76 71494,32 67329,57 70680,06 Alpha-1-antitrypsin 1-5 OS=Mus musculus GN=Serpina1e PE=1 SV=1 Q61129 6 5 202,71 2,83E-03 211329,59 128535,14 132489,49 135384,03 183512,52 147961,32 123945,05 112069,75 137485,83 Ig heavy chain V region MOPC 47A OS=Mus musculus PE=1 SV=1 Q9CR16 6 5 250,61 2,85E-03 428616,57 394685,49 328340,12 247144,46 266209,69 334239,27 170060,11 179181,29 231979,92 EH domain-containing protein 2 OS=Mus musculus GN=Ehd2 PE=1 SV=1 Q99L45 6 5 217,14 4,00E-03 118314,64 138194,38 151185,14 127741,74 127072,93 121332,51 97277,04 79327,23 97554,01 Programmed cell death 6-interacting protein OS=Mus musculus GN=Pdcd6ip PE=1 SV=3 Q8BXK9 6 5 304,75 4,71E-03 77991,64 79333,56 82338,45 94856,86 114956,95 102533,79 101620,06 153348,37 132524,13 Coiled-coil domain-containing protein 127 OS=Mus musculus GN=Ccdc127 PE=1 SV=2 Q9Z1W9 6 5 233,50 5,56E-03 319922,72 210737,11 175541,82 181453,76 206351,14 188034,54 114743,17 122648,39 137697,01 Tubulin beta-2A chain OS=Mus musculus GN=Tubb2a PE=1 SV=1 Q8K1R3 5 5 243,25 6,49E-03 91674,85 93065,12 111961,13 192047,86 248091,03 213473,65 93243,66 99213,69 173477,26 Ras-related protein Ral-A OS=Mus musculus GN=Rala PE=1 SV=1 P37040 5 5 182,25 7,35E-03 79417,84 93119,75 102532,85 187189,12 180465,74 184471,14 127063,76 148218,44 216485,49 Carbonyl reductase [NADPH] 1 OS=Mus musculus GN=Cbr1 PE=1 SV=3 P31230 6 5 221,79 9,70E-03 264037,26 277710,97 267753,71 191026,19 177309,12 200283,54 211752,46 217156,01 149779,29 Acyl-protein thioesterase 2 OS=Mus musculus GN=Lypla2 PE=1 SV=1 Q99PL5 7 5 363,29 1,66E-02 43483,61 46887,21 55418,63 72575,25 73498,96 103869,04 40091,52 47839,53 78400,39 Transgelin-2 OS=Mus musculus GN=Tagln2 PE=1 SV=4 Q8BGD9 6 5 334,06 2,13E-02 128100,36 128831,37 106972,70 90219,11 79787,45 97878,57 95804,54 75695,74 81766,51 28S ribosomal protein S17, mitochondrial OS=Mus musculus GN=Mrps17 PE=1 SV=1 Q59J78 5 5 180,28 2,57E-02 367029,44 340565,36 343578,77 411197,37 515929,72 460861,72 274892,98 311700,43 359612,62 Alpha-parvin OS=Mus musculus GN=Parva PE=1 SV=1 Q91YY4 5 5 191,75 3,20E-02 93291,89 92579,94 82189,53 170539,13 145434,18 130774,77 78843,46 98817,68 159491,40 OS=Mus musculus GN=Rnls PE=1 SV=2 Q2L4X1 8 5 376,52 3,30E-02 146828,29 181302,76 195779,57 247495,02 253349,78 277265,17 176105,53 186299,80 256324,80 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=1 SV=2 Q6P9R2 6 5 290,74 3,35E-02 94824,07 86896,44 105687,70 101763,19 118967,79 152665,74 113154,70 121163,02 173601,11 Ran-binding protein 3 OS=Mus musculus GN=Ranbp3 PE=1 SV=2 Q9D967 5 5 346,26 3,78E-02 485484,42 495246,65 708503,49 959687,21 829562,28 780475,69 731625,65 703785,27 1048220,83 LYR motif-containing protein 9 OS=Mus musculus GN=Lyrm9 PE=3 SV=1 Q9CY64 7 5 343,99 3,90E-02 166738,26 228694,49 172802,07 244064,25 214223,88 232154,51 198668,37 185042,42 277517,70 Acetyl-CoA carboxylase 2 OS=Mus musculus GN=Acacb PE=1 SV=1 Q3B7Z2 7 5 447,35 4,33E-02 143066,01 151185,47 145286,21 156994,08 130920,54 146142,39 128755,26 149934,10 130593,65 Ig kappa chain V-V region MOPC 21 OS=Mus musculus PE=1 SV=1 Q9DB73 5 5 157,63 5,10E-02 58961,46 57908,50 92074,72 134435,35 113765,63 143002,66 72819,52 72180,03 132973,83 Ester hydrolase C11orf54 homolog OS=Mus musculus PE=1 SV=1 O08715 6 5 213,17 5,23E-02 67642,25 61939,07 91779,05 50902,70 59028,65 65792,65 77126,75 91797,63 67234,92 T-complex protein 1 subunit eta OS=Mus musculus GN=Cct7 PE=1 SV=1 Q9ERI6 5 5 231,87 5,39E-02 16495,05 48573,93 45937,59 63383,36 79319,20 80205,06 105031,67 94342,50 52726,93 Alcohol dehydrogenase class-3 OS=Mus musculus GN=Adh5 PE=1 SV=3 Q99LF4 5 5 176,59 5,44E-02 112782,14 140716,30 175388,46 179364,97 170427,84 260371,24 217097,60 133704,28 212021,03 OS=Mus musculus GN=Lpl PE=1 SV=3 P68254 12 5 689,44 5,79E-02 325113,16 327270,25 340226,00 376562,38 375904,33 420427,50 217993,13 281134,08 345551,73 Centrosomal protein of 164 kDa OS=Mus musculus GN=Cep164 PE=1 SV=2 P10630 12 5 712,76 5,99E-02 314374,08 371047,65 770465,06 1281185,99 722367,97 1022284,26 824433,25 667549,63 1151917,02 Complement C3 OS=Mus musculus GN=C3 PE=1 SV=3 Q8WTY4 5 5 255,23 6,07E-02 184744,03 165589,66 212749,83 301461,60 354412,96 324068,11 216075,39 162503,38 307833,58 Ig lambda-1 chain C region OS=Mus musculus PE=1 SV=1 P68368;Q3UX10 19 5 1256,27 6,09E-02 1516900,20 1677198,08 1303292,13 1661314,44 2475487,96 2747402,55 2445259,01 1877728,10 2491077,32 Guanine nucleotide-binding protein G(o) subunit alpha OS=Mus musculus GN=Gnao1 PE=1 SV=3 P26350 5 5 354,66 7,40E-02 363670,64 381715,73 340314,57 297588,46 290534,07 194552,36 230848,44 229576,52 333447,03 OS=Mus musculus GN=Dnpep PE=1 SV=2 Q8BZA9 5 5 247,24 7,40E-02 340743,52 278988,94 264002,07 370831,03 319945,65 284462,37 221014,94 202280,83 348640,77 Xanthine dehydrogenase/oxidase OS=Mus musculus GN=Xdh PE=1 SV=5 P45591 6 5 332,57 7,67E-02 1514434,59 1391066,15 1596665,36 1855453,79 2360289,33 2069020,79 1721692,76 1477728,70 2346692,93 Transcription factor BTF3 homolog 4 OS=Mus musculus GN=Btf3l4 PE=1 SV=1 Q9JJZ2 16 5 891,09 7,67E-02 204425,83 169029,64 184396,65 130627,45 217772,10 222500,72 118541,35 154865,26 150707,53 WD repeat-containing protein 1 OS=Mus musculus GN=Wdr1 PE=1 SV=3 Q3UH68 6 5 313,00 8,17E-02 75247,92 76320,60 96305,24 49970,71 61188,96 71809,06 40094,99 65916,09 64149,33 Aspartate--tRNA ligase, cytoplasmic OS=Mus musculus GN=Dars PE=1 SV=2 Q8R1G2 5 5 195,81 8,26E-02 264521,45 328976,22 358241,02 410853,34 337356,19 331658,67 260668,71 278084,37 378929,51 subunit alpha-2 OS=Mus musculus GN=Lama2 PE=1 SV=2 O70622 5 5 286,35 8,44E-02 1220765,69 1666924,62 1932251,57 1729159,58 2005917,07 1908634,83 1855035,80 2307083,76 1466935,86 Cytochrome b5 type B OS=Mus musculus GN=Cyb5b PE=1 SV=1 P12367;P31324 5 5 330,54 9,45E-02 588955,94 697241,76 1221947,62 831224,26 1106608,77 813665,27 601681,00 538323,87 631292,25 Dynactin subunit 2 OS=Mus musculus GN=Dctn2 PE=1 SV=3 P14685 6 5 185,28 9,70E-02 145911,68 153155,01 198092,67 222622,36 120767,83 269832,99 208136,82 249327,19 247634,51 O-phosphoseryl-tRNA(Sec) selenium transferase OS=Mus musculus GN=Sepsecs PE=1 SV=2 Q61703 5 5 214,92 1,03E-01 298715,22 78436,28 265401,05 106805,31 125782,32 146373,30 344055,72 344113,27 253982,79 14 kDa phosphohistidine phosphatase OS=Mus musculus GN=Phpt1 PE=1 SV=1 Q61102 6 5 296,01 1,07E-01 82739,50 112990,78 87983,43 151417,75 208780,44 235204,80 58855,50 93808,04 155563,67 --tRNA ligase, mitochondrial OS=Mus musculus GN=Fars2 PE=1 SV=1 Q9D020 5 5 361,99 1,16E-01 532239,27 591816,15 632906,96 578964,51 669407,03 774543,16 610843,50 986648,84 877526,65 Dynein light chain roadblock-type 1 OS=Mus musculus GN=Dynlrb1 PE=1 SV=3 P97372 5 5 188,55 1,18E-01 266007,20 289505,01 243052,19 333562,80 270801,11 357120,13 270840,49 238865,92 311570,70 Serine/arginine-rich splicing factor 3 OS=Mus musculus GN=Srsf3 PE=1 SV=1 P00397 5 5 309,24 1,27E-01 807172,34 891771,19 1723825,84 1222367,94 1550072,86 1065031,08 4441586,62 5394558,04 1267890,78 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Mus musculus GN=Hnrnpc PE=1 SV=1 Q3UN02 5 5 144,24 1,29E-01 573803,22 756968,55 639756,60 508002,21 561803,61 462864,79 622565,30 547717,11 602654,19 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 P84091 5 5 145,00 1,33E-01 198928,44 175131,30 154570,05 161012,66 243162,16 225736,99 177728,35 78526,63 157087,62 resident protein 29 OS=Mus musculus GN=Erp29 PE=1 SV=2 P61027;Q9DD03 8 5 525,12 1,34E-01 259128,08 340415,39 386153,75 348418,17 495818,20 573092,74 555362,94 529077,02 317121,34 Malignant T-cell-amplified sequence 2 OS=Mus musculus GN=Mcts2 PE=1 SV=1 Q6ZWX6 5 5 275,97 1,42E-01 111275,63 105697,53 116905,15 141254,92 132371,47 128011,54 80705,59 78871,50 131631,05 Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Mus musculus GN=Dhodh PE=1 SV=2 Q8BG51 6 5 275,35 1,44E-01 76871,18 115937,46 97104,26 101656,09 100145,48 101976,96 108847,77 81354,70 91987,69 Serine-threonine kinase receptor-associated protein OS=Mus musculus GN=Strap PE=1 SV=2 Q6NVE9 5 5 359,71 1,44E-01 99623,01 91630,62 96806,63 176857,93 195152,66 185378,10 76416,42 107341,61 246210,58 Filamin-B OS=Mus musculus GN=Flnb PE=1 SV=3 Q9DBD0 6 5 258,60 1,46E-01 115081,31 43407,73 61060,34 107189,93 121091,00 59663,70 96136,14 40843,01 87978,56 Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1 Q60737 5 5 183,84 1,50E-01 70349,56 78406,23 76861,94 84174,84 126924,38 98592,04 97957,68 67616,59 92895,71 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 P63005 7 5 265,58 1,50E-01 232301,57 204945,02 231917,75 182642,65 166553,15 181549,97 206992,91 165560,82 173329,05 60S ribosomal protein L28 OS=Mus musculus GN=Rpl28 PE=1 SV=2 Q8VDK1 5 5 242,11 1,55E-01 94821,56 82061,22 117188,88 95027,70 95562,35 86019,27 52937,11 60347,17 86452,55 Hormone-sensitive lipase OS=Mus musculus GN=Lipe PE=1 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q7TMK9 5 5 236,00 1,59E-01 69969,11 96312,70 175189,10 168808,76 123592,20 181835,76 122012,56 149560,92 193201,17 OS=Mus musculus GN=Cast PE=1 SV=2 Q8BGC4 5 5 263,56 1,60E-01 519093,62 722178,60 755461,90 1100357,86 1111157,33 730734,88 612318,93 702633,14 1026578,07 Ig kappa chain V-III region PC 3741/TEPC 111 OS=Mus musculus PE=1 SV=1 O35295 5 5 303,25 1,61E-01 89038,56 85070,67 96647,22 95629,69 121927,33 149211,78 105634,17 119105,51 107900,99 Ig kappa chain V-III region PC 2154 OS=Mus musculus PE=1 SV=1 Q6PHZ2;P11798 7 5 450,16 1,64E-01 528847,31 579922,67 528303,14 517680,98 573875,05 617528,37 680018,42 548913,02 515117,62 Mitochondrial fission process protein 1 OS=Mus musculus GN=Mtfp1 PE=1 SV=1 P63321;Q9JIW9 7 5 266,23 1,71E-01 158796,39 199739,12 163094,60 177365,04 171933,91 213036,60 233285,43 198337,30 191208,58 L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Mus musculus GN=L2hgdh PE=1 SV=1 Q8R164 5 5 311,63 1,81E-01 663128,27 761124,26 708485,69 791664,10 587533,95 817064,09 609485,40 773035,72 867411,37 ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Mus musculus GN=Supv3l1 PE=1 SV=1 O35435 6 5 323,27 1,82E-01 36079,09 39950,89 26460,86 55430,78 56694,89 52173,91 29256,09 42707,77 78769,50 Early endosome antigen 1 OS=Mus musculus GN=Eea1 PE=1 SV=2 Q8C8R3 7 5 320,08 2,06E-01 31048,21 40516,64 35380,12 33218,21 36325,93 27450,26 32034,97 28345,65 24833,33 Eukaryotic translation initiation factor 3 subunit D OS=Mus musculus GN=Eif3d PE=1 SV=2 Q7TMY8 7 5 253,17 2,08E-01 28332,76 30430,32 25428,49 35122,96 46939,29 36867,08 28718,70 30320,34 50183,20 E3 ubiquitin-protein ligase RNF114 OS=Mus musculus GN=Rnf114 PE=1 SV=2 Q60676 5 5 328,64 2,13E-01 43656,13 56102,70 66667,47 98716,12 63097,52 91881,73 69009,80 53344,77 76704,75 CapZ-interacting protein OS=Mus musculus GN=Rcsd1 PE=1 SV=1 Q8R081 5 5 235,55 2,36E-01 205268,35 251294,17 291839,20 146009,87 196175,77 319633,82 190274,48 292290,35 165655,06 Alpha-2-macroglobulin OS=Mus musculus GN=A2m PE=1 SV=3 Q9CQJ8 5 5 354,18 2,36E-01 10600783,87 9609241,51 8243025,55 6065694,32 6765373,24 7247019,28 11630516,98 6325331,27 4991205,97 40S ribosomal protein S11 OS=Mus musculus GN=Rps11 PE=1 SV=3 Q922R8 6 5 309,09 2,38E-01 289770,35 469669,53 368954,51 334087,07 412965,05 488314,36 566235,89 366931,40 511210,30 Plastin-2 OS=Mus musculus GN=Lcp1 PE=1 SV=4 Q9CWE0 5 5 272,40 2,55E-01 452925,82 463508,17 152222,42 188852,23 210309,09 206970,00 223540,63 178553,05 170275,01 Ig gamma-2A chain C region secreted form OS=Mus musculus PE=1 SV=1 P51859;Q99JF8 7 5 283,02 2,62E-01 383470,65 376235,60 447189,02 380941,95 374800,48 410685,64 371367,16 355776,68 523530,42 Transmembrane protein 205 OS=Mus musculus GN=Tmem205 PE=1 SV=1 P08003 5 5 275,64 2,68E-01 84036,79 71747,20 93561,87 75159,42 53564,90 97293,26 178473,79 73572,14 135468,89 Phosphoglycerate mutase 1 OS=Mus musculus GN=Pgam1 PE=1 SV=3 P12787 8 5 479,43 2,75E-01 36307333,18 26407150,65 35287436,70 29998830,48 38967218,89 26400022,19 62914576,47 38761093,89 32083222,15 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Mus musculus GN=Idh3a PE=1 SV=1 Q8BG05 5 5 268,98 2,79E-01 789002,73 880557,84 680884,45 469138,09 644537,37 723272,00 727397,48 707271,71 551989,06 Sorting nexin-5 OS=Mus musculus GN=Snx5 PE=1 SV=1 P99028 5 5 205,76 2,88E-01 1469726,81 1797928,53 2919757,63 1650863,53 2098169,28 1945309,58 3506348,13 3227298,51 1598738,35 Fructose-bisphosphate OS=Mus musculus GN=Aldoa PE=1 SV=2 Q3TMH2 7 5 360,01 2,89E-01 253987,69 217564,81 209198,78 215349,83 188564,15 156318,62 187701,50 139826,44 237076,80 Ras-related C3 botulinum toxin substrate 1 OS=Mus musculus GN=Rac1 PE=1 SV=1 P52196 7 5 276,77 2,90E-01 479512,70 632198,85 510752,78 478656,03 614002,61 433219,74 365072,66 431313,73 600498,47 Four and a half LIM domains protein 3 OS=Mus musculus GN=Fhl3 PE=1 SV=2 P61202 5 5 180,89 2,92E-01 163853,11 213531,30 195613,53 294547,83 232285,87 253678,50 257945,13 144610,32 281629,34 Dystrobrevin alpha OS=Mus musculus GN=Dtna PE=1 SV=2 P56375 6 5 284,53 2,94E-01 1067310,65 884772,93 1874589,28 1766129,80 1512784,38 1750150,88 1410909,49 1449551,99 2219148,76 Rho-associated protein kinase 2 OS=Mus musculus GN=Rock2 PE=1 SV=1 Q8VE95 5 5 216,12 2,95E-01 1155181,87 1046323,39 1131368,96 1048267,72 1112595,47 991684,27 733854,15 949446,87 1047613,30 Far upstream element-binding protein 2 OS=Mus musculus GN=Khsrp PE=1 SV=2 Q61081 5 5 274,92 2,98E-01 281213,74 217638,89 259492,25 282106,72 340782,65 335094,04 197129,07 207786,55 363247,30 Myotubularin OS=Mus musculus GN=Mtm1 PE=1 SV=2 Q9WVQ5 5 5 300,97 3,01E-01 294778,23 313747,58 381945,91 524235,33 552552,16 445928,84 227882,96 257765,70 549525,51 Delta-aminolevulinic acid dehydratase OS=Mus musculus GN=Alad PE=1 SV=1 P56391 5 5 316,53 3,06E-01 4873110,86 3265029,46 3314429,19 2901873,85 3444301,50 2611063,04 5529030,41 3535950,75 3139054,36 Natriuretic A OS=Mus musculus GN=Nppa PE=1 SV=2 Q9Z2U1 5 5 357,63 3,07E-01 1266437,48 1187346,68 816792,98 769802,79 752073,24 756814,15 1278763,30 832795,41 720614,14 60S ribosomal protein L35 OS=Mus musculus GN=Rpl35 PE=1 SV=1 Q9CVB6 5 5 125,70 3,14E-01 178590,68 163851,32 246129,23 210235,04 177749,32 239206,59 168853,10 246794,32 129423,36 Protein preY, mitochondrial OS=Mus musculus GN=Pyurf PE=1 SV=1 P56565 6 5 485,52 3,24E-01 9976164,33 9239396,96 11074003,95 10402134,01 6879098,83 7856378,49 11043984,24 9635850,85 7104195,25 OS=Mus musculus GN=Gk PE=1 SV=2 P19123 5 5 414,29 3,25E-01 17404709,82 19690268,65 17755536,84 10370229,64 8078015,64 13357680,79 34970331,43 26391537,58 6813068,78 -1 OS=Mus musculus GN=Tln1 PE=1 SV=2 O09044 5 5 341,49 3,32E-01 67903,06 62910,85 76536,30 76228,48 87330,46 103459,44 64886,30 55769,59 90044,91 ATP-dependent 6-phosphofructokinase, platelet type OS=Mus musculus GN=Pfkp PE=1 SV=1 Q9D1A2 7 5 202,55 3,37E-01 237389,14 285986,51 448581,35 570074,38 417807,05 401060,78 345097,37 224606,64 325048,03 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Mus musculus GN=Uqcrfs1 PE=1 SV=1 P54775 6 5 393,60 3,40E-01 340012,95 157540,73 202953,38 314194,65 315163,15 286157,18 268374,96 183904,13 280226,43 Histone H2B type 1-C/E/G OS=Mus musculus GN=Hist1h2bc PE=1 SV=3 Q922Q1 5 5 184,45 3,49E-01 147217,73 76472,55 149871,98 156428,11 126632,92 194386,78 167483,03 160709,15 152309,99 Fibroblast growth factor 1 OS=Mus musculus GN=Fgf1 PE=1 SV=1 Q6ZWV3;P86048 5 5 181,92 3,49E-01 145595,44 195412,44 143662,88 140823,68 142789,59 185422,62 153191,95 137942,16 117896,33 Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Mus musculus GN=Fkbp3 PE=1 SV=2 Q9R069 6 5 339,33 3,58E-01 230919,13 235801,51 291063,13 233538,43 253837,18 250307,63 391254,59 475157,35 220210,62 Retinol-binding protein 1 OS=Mus musculus GN=Rbp1 PE=1 SV=2 P62880;P29387;Q6101111 5 698,30 3,60E-01 1033913,65 1041628,55 463951,65 624461,60 667957,08 610772,23 559867,18 554542,91 579031,91 OS=Mus musculus GN=Gda PE=1 SV=1 Q99JI6;P62835 9 5 460,15 3,63E-01 1477034,23 715389,97 623865,98 988939,57 625445,09 1004201,66 648466,76 893962,62 712230,25 Catenin alpha-1 OS=Mus musculus GN=Ctnna1 PE=1 SV=1 Q9WU79 5 5 175,55 3,65E-01 2435941,56 2116650,94 504698,53 522894,08 490385,44 358629,47 2848401,55 564713,90 408636,34 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial OS=Mus musculus GN=Nudt8 PE=1 SV=1 Q791V5 5 5 246,72 3,66E-01 668176,44 680561,64 1360761,12 412782,82 794190,03 599029,97 1270523,14 1519825,14 669824,92 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 OS=Mus musculus GN=Ndufs5 PE=1 SV=3 Q9D1X0 6 5 454,45 3,66E-01 558197,51 729477,61 1207264,87 900382,33 830085,44 835220,98 601913,83 576306,31 693601,97 Dual specificity protein phosphatase 3 OS=Mus musculus GN=Dusp3 PE=1 SV=1 P61089;Q9CQ37 5 5 250,90 3,74E-01 1842719,24 2335383,24 1844490,19 1612099,82 1573997,08 1752026,38 1942193,36 1306662,76 1994869,70 -3 OS=Mus musculus GN=Ank3 PE=1 SV=1 P24549 10 5 537,68 3,74E-01 657245,18 712924,86 214145,92 242007,52 226545,07 138632,40 673623,15 170746,08 270152,88 Cell division cycle-associated protein 2 OS=Mus musculus GN=Cdca2 PE=1 SV=2 Q8VDC0;Q9D9J8 5 5 222,06 4,26E-01 133796,72 150720,67 107869,95 118336,72 247982,82 133897,61 100863,82 99127,69 134186,21 UMP-CMP kinase 2, mitochondrial OS=Mus musculus GN=Cmpk2 PE=1 SV=2 Q9WUK2 5 5 174,71 4,37E-01 133991,22 167390,06 122922,98 161882,73 156053,07 131888,95 97572,66 90877,40 169432,70 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 P31786 5 5 256,65 4,49E-01 10579194,90 9588391,91 8611751,43 8422278,08 9624844,34 6570618,28 6120336,80 7017866,38 10203030,07 Protein NDRG2 OS=Mus musculus GN=Ndrg2 PE=1 SV=1 Q9ESW4 6 5 208,74 4,49E-01 98406,70 141018,64 154943,09 138476,72 164144,06 199757,01 116586,02 147329,52 163961,17 Methionine--tRNA ligase, mitochondrial OS=Mus musculus GN=Mars2 PE=1 SV=2 Q9JKR6 6 5 220,73 4,54E-01 144207,94 106580,30 114420,67 154970,56 153196,38 135829,05 138488,62 186884,76 128897,99 ADP/ATP translocase 4 OS=Mus musculus GN=Slc25a31 PE=1 SV=1 O88456;Q9D7J7 5 5 384,84 4,55E-01 278156,20 270390,48 323347,75 269174,57 266349,64 314385,41 234798,62 286491,93 266015,75 Very-long-chain enoyl-CoA reductase OS=Mus musculus GN=Tecr PE=1 SV=1 P38060 5 5 343,95 4,55E-01 734936,98 674560,86 1125916,32 996788,70 925816,29 774156,30 799024,93 618785,01 851322,93 E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus GN=Huwe1 PE=1 SV=5 O54988 7 5 345,22 4,61E-01 73325,19 71854,64 61513,00 81897,57 87820,28 61220,86 55614,13 52695,14 96956,99 Macrophage-capping protein OS=Mus musculus GN=Capg PE=1 SV=2 P49138;Q3UMW7 5 5 198,31 4,76E-01 90320,68 91750,98 72992,44 72477,61 85010,33 73805,57 46796,43 37303,53 108794,02 Ras-related protein Rab-11B OS=Mus musculus GN=Rab11b PE=1 SV=3 Q8BMJ2 5 5 197,23 4,82E-01 21443,02 13671,44 65550,10 41813,41 51528,79 36501,42 27593,06 41521,17 62582,45 Gamma-soluble NSF attachment protein OS=Mus musculus GN=Napg PE=1 SV=1 A3KMP2 7 5 351,23 4,84E-01 117598,40 168663,46 122146,11 152228,37 135342,42 114006,86 74954,18 105704,68 145159,12 Voltage-dependent anion-selective channel protein 1 OS=Mus musculus GN=Vdac1 PE=1 SV=3 P60843;Q91VC3 12 5 774,35 4,85E-01 316861,65 476532,19 350519,40 341042,40 343787,34 379014,11 457685,06 293770,41 292825,65 Aldose 1-epimerase OS=Mus musculus GN=Galm PE=1 SV=1 P47962 5 5 187,53 4,96E-01 152656,83 151021,45 167900,66 124727,22 143605,63 175035,96 180879,71 136811,70 92185,43 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Mus musculus GN=Etfdh PE=1 SV=1 P97450 5 5 364,63 4,96E-01 2948313,10 5282546,11 4631530,59 5555838,82 6664810,22 4815681,49 2614980,57 4238318,09 5559725,41 Thioredoxin-related transmembrane protein 4 OS=Mus musculus GN=Tmx4 PE=1 SV=2 Q8C0M9 6 5 408,25 5,07E-01 658574,84 497859,41 392826,61 538644,49 434397,28 416353,72 318095,91 330622,29 628554,80 Ig mu chain C region OS=Mus musculus GN=Ighm PE=1 SV=2 Q9DC70 6 5 405,93 5,08E-01 3442132,50 3395207,78 4072722,85 2858663,99 2836382,03 2995019,27 4247362,74 3605210,04 2148795,31 Putative transferase CAF17 homolog, mitochondrial OS=Mus musculus GN=Iba57 PE=1 SV=1 Q9D273 5 5 265,56 5,09E-01 203732,41 172287,55 164735,38 156600,34 135308,20 137888,32 159717,66 123038,19 207510,54 Tripartite motif-containing protein 72 OS=Mus musculus GN=Trim72 PE=1 SV=1 O09061 5 5 297,14 5,12E-01 1017487,35 945936,09 608057,07 748711,72 717712,16 852248,32 1073153,38 787754,87 839828,88 Serine/threonine-protein phosphatase 5 OS=Mus musculus GN=Ppp5c PE=1 SV=3 Q8C5H8 5 5 228,95 5,14E-01 57049,51 97287,90 106689,35 113441,35 99856,57 71341,96 85075,33 123495,71 116961,77 Beta-2-microglobulin OS=Mus musculus GN=B2m PE=1 SV=2 O35143 7 5 288,11 5,16E-01 297852,69 308940,10 299665,03 252072,42 322440,27 341246,15 429761,68 313597,54 289690,27 Translationally-controlled tumor protein OS=Mus musculus GN=Tpt1 PE=1 SV=1 Q64442 5 5 197,65 5,28E-01 266067,06 238501,69 179284,59 215942,98 206466,39 281056,80 285248,26 190585,57 330176,83 -binding protein 7 OS=Mus musculus GN=Rbp7 PE=1 SV=1 P84078;Q8BSL7 9 5 522,95 5,33E-01 1805070,27 2024695,46 2170375,60 1979906,96 1924443,42 2231415,65 1973178,72 2071456,51 2069542,36 , mitochondrial OS=Mus musculus GN=Pc PE=1 SV=1 Q8BJU0 5 5 204,53 5,40E-01 95547,37 132757,28 126370,06 112537,62 165241,60 127126,17 150282,73 91950,43 155649,56 Peroxisomal biogenesis factor 19 OS=Mus musculus GN=Pex19 PE=1 SV=1 Q9QUI0;Q62159 5 5 276,54 5,46E-01 611207,33 445171,58 456860,73 450996,92 406037,41 409025,49 641717,44 479328,67 422339,13 Multifunctional protein ADE2 OS=Mus musculus GN=Paics PE=1 SV=4 Q06890 6 5 312,80 5,54E-01 332094,36 164348,58 110192,13 178436,09 256256,23 122304,31 242929,55 138073,07 142507,48 Phosphorylase b kinase regulatory subunit alpha, isoform OS=Mus musculus GN=Phka1 PE=1 SV=3 Q99PR8 6 5 233,15 5,55E-01 469955,60 265137,07 318483,77 272306,14 431563,69 596758,39 1085413,41 437036,11 430527,58 Interleukin enhancer-binding factor 3 OS=Mus musculus GN=Ilf3 PE=1 SV=2 Q9CRB9 8 5 586,81 5,58E-01 1446157,40 1481890,69 2218197,77 1824246,43 2019278,57 1749540,23 2449998,29 1531327,24 1849926,20 V-type proton ATPase subunit C 1 OS=Mus musculus GN=Atp6v1c1 PE=1 SV=4 O89086 5 5 276,13 5,65E-01 386633,61 616387,88 319687,90 313708,46 497718,45 221196,55 300270,75 277834,05 398802,98 V-type proton ATPase catalytic subunit A OS=Mus musculus GN=Atp6v1a PE=1 SV=2 Q9CPU4 6 5 311,71 5,84E-01 2330945,78 2315749,55 2334531,76 2152314,17 2560335,94 2256768,38 4757418,14 3588991,92 1448138,48 Gamma-synuclein OS=Mus musculus GN=Sncg PE=1 SV=1 Q9JM76 5 5 294,99 5,88E-01 248705,47 283108,61 254142,59 322360,10 280294,44 305454,22 255931,47 182877,36 332506,29 Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Mus musculus GN=Chchd7 PE=1 SV=1 Q9WVE8 7 5 280,77 6,01E-01 253304,68 294027,46 239655,53 320761,87 245093,46 295693,30 229376,51 271384,43 323464,84 Glycylpeptide N-tetradecanoyltransferase 2 OS=Mus musculus GN=Nmt2 PE=1 SV=1 P97461 5 5 234,48 6,08E-01 226462,60 289679,47 225404,71 258684,69 315429,57 322137,07 262801,12 278658,96 197819,09 LDLR chaperone MESD OS=Mus musculus GN=Mesdc2 PE=1 SV=1 Q9CQ91 5 5 324,75 6,13E-01 5082071,66 6477270,23 7225704,75 6785877,89 9755649,82 7182733,18 10508305,53 5903302,28 5944774,74 Astrocytic phosphoprotein PEA-15 OS=Mus musculus GN=Pea15 PE=1 SV=1 Q9QY76 7 5 425,27 6,16E-01 894729,31 865519,91 702570,09 939749,58 932467,12 877510,32 736005,98 686348,82 995694,41 Transthyretin OS=Mus musculus GN=Ttr PE=1 SV=1 Q8VBW6 6 5 328,47 6,18E-01 127525,50 179570,01 126822,94 144558,73 138990,37 133643,51 140831,86 97199,07 142265,23 Ubiquitin-protein ligase E3A OS=Mus musculus GN=Ube3a PE=1 SV=2 Q71FD7 5 5 230,03 6,19E-01 172048,31 207948,33 152983,57 148704,49 133138,95 191575,02 172480,27 210631,48 119742,86 Transketolase OS=Mus musculus GN=Tkt PE=1 SV=1 Q99JB8 5 5 303,15 6,53E-01 252241,16 285354,90 256278,08 218752,63 237898,12 203714,31 184978,77 303935,35 270164,54 LIM zinc-binding domain-containing Nebulette OS=Mus musculus GN=Nebl PE=1 SV=1 Q8K4L3 6 5 262,78 6,97E-01 8472,74 32882,02 32478,29 22747,74 38832,59 30439,08 9433,41 28535,28 18911,47 Ig heavy chain V region AC38 205.12 OS=Mus musculus PE=1 SV=1 Q8R1B4 6 5 372,67 7,04E-01 54823,91 85755,54 103567,94 84644,45 90426,93 85153,73 99928,08 74004,55 88323,93 Transcription intermediary factor 1-beta OS=Mus musculus GN=Trim28 PE=1 SV=3 P56380 7 5 353,13 7,04E-01 301052,03 302542,56 312973,89 297439,54 286884,93 318402,45 169709,90 262413,85 343193,19 Septin-8 OS=Mus musculus GN=Sept8 PE=1 SV=4 Q9CPU0 5 5 269,69 7,13E-01 508743,72 883937,73 1233808,02 902536,42 523156,35 850187,18 959514,24 1370740,73 874494,95 Cysteine-rich protein 1 OS=Mus musculus GN=Crip1 PE=1 SV=2 P85094 6 5 416,57 7,25E-01 2138785,83 1770462,77 1323855,71 2085478,43 1950210,82 1490586,02 1467198,96 1132634,83 2064577,46 Propionyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus GN=Pccb PE=1 SV=2 P42208 5 5 297,55 7,38E-01 161248,24 170092,02 163698,50 160969,18 139604,62 176204,62 114734,81 112601,70 200428,01 Calpain-2 catalytic subunit OS=Mus musculus GN=Capn2 PE=1 SV=4 Q99L47 5 5 261,60 7,47E-01 194236,35 423435,03 538459,21 492502,43 316509,58 438575,93 214359,05 560898,15 571631,66 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Mus musculus GN=Gatb PE=1 SV=1 P56395 5 5 308,13 7,47E-01 1565307,31 1841632,04 1116759,07 1202729,63 1353549,63 915686,33 2404841,51 1157736,88 814628,95 Ras-related protein Rab-1A OS=Mus musculus GN=Rab1A PE=1 SV=3 P07356 5 5 199,55 7,63E-01 120307,73 196366,15 346915,73 195401,73 184816,47 182354,77 238828,17 423604,68 178102,82 Protein phosphatase 1 regulatory subunit 12C OS=Mus musculus GN=Ppp1r12c PE=1 SV=1 O09174 6 5 356,86 7,75E-01 177386,46 192422,71 220395,91 191489,13 227031,83 193422,48 206839,17 127398,60 294585,75 Glycogen synthase kinase-3 alpha OS=Mus musculus GN=Gsk3a PE=1 SV=2 Q9ERK4 8 5 323,07 7,83E-01 74794,06 50543,11 50326,07 65955,21 53519,94 74606,03 56379,46 47474,81 85917,07 UMP-CMP kinase OS=Mus musculus GN=Cmpk1 PE=1 SV=1 Q9Z1Z0 7 5 229,25 7,87E-01 79896,77 73873,55 61172,34 79066,03 67555,26 87836,47 52434,59 73783,66 82951,94 Ankyrin repeat domain-containing protein 1 OS=Mus musculus GN=Ankrd1 PE=1 SV=1 P62702 6 5 327,79 7,92E-01 291326,91 321167,49 457166,74 326766,07 321605,97 427279,58 347462,01 432058,40 294518,31 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Mus musculus GN=Ndufs3 PE=1 SV=2 Q8BP40 7 5 324,17 7,93E-01 191864,00 305652,51 235772,42 281899,95 208266,39 208142,64 255360,72 200748,93 285444,73 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Mus musculus GN=Bckdha PE=1 SV=1 Q91WJ8 5 5 258,50 8,09E-01 70159,93 74635,20 53200,75 61743,48 63319,14 61300,01 47889,59 43591,51 70873,66 60S ribosomal protein L26 OS=Mus musculus GN=Rpl26 PE=1 SV=1 Q9CQ65 6 5 332,60 8,32E-01 300965,41 478890,46 267371,22 393430,98 301969,48 411690,23 253581,04 290349,36 456197,82 Ubiquitin-conjugating enzyme E2 variant 1 OS=Mus musculus GN=Ube2v1 PE=1 SV=1 P40630 6 5 204,98 9,01E-01 803786,00 787888,23 815894,99 784661,74 821678,27 774926,48 696966,40 702910,97 958613,34 Glia maturation factor beta OS=Mus musculus GN=Gmfb PE=1 SV=3 P10639 5 4 213,35 1,93E-03 3940517,43 3189966,97 3537191,85 3314565,54 3407985,76 3617949,16 4222826,68 3647341,08 3452884,70 Ubiquinol-cytochrome-c reductase complex assembly factor 2 OS=Mus musculus GN=Uqcc2 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q68FL4 5 4 164,29 5,17E-03 437721,95 365598,64 334966,42 402101,73 387742,56 318498,11 346018,49 354978,45 514926,26 Glutathione peroxidase 1 OS=Mus musculus GN=Gpx1 PE=1 SV=2 P42703 4 4 232,43 5,53E-03 162010,21 118954,95 111180,54 91310,48 146020,79 105513,19 58458,07 77222,57 85335,76 Elongation factor G, mitochondrial OS=Mus musculus GN=Gfm1 PE=1 SV=1 Q9CR21 4 4 296,25 6,26E-03 10937282,33 9923706,77 7794933,96 6220229,56 6533183,40 6392634,62 7150898,88 5308135,93 5149113,07 Transcription elongation factor B polypeptide 2 OS=Mus musculus GN=Tceb2 PE=1 SV=1 Q9JII6 4 4 258,92 6,27E-03 375424,81 410347,74 376422,14 374988,44 331082,43 352786,12 271112,96 272662,01 355667,95 Regulator of microtubule dynamics protein 1 OS=Mus musculus GN=Rmdn1 PE=1 SV=2 Q8R0Y8 4 4 198,92 1,07E-02 231299,76 290237,98 253503,46 388878,01 680839,72 478357,55 268452,34 343171,81 343819,04 Nodal modulator 1 OS=Mus musculus GN=Nomo1 PE=1 SV=1 P10107 6 4 365,54 1,34E-02 36518,35 51719,06 85056,07 129552,80 129437,30 102147,96 100657,51 86344,77 86041,76 Eukaryotic translation initiation factor 3 subunit J-A OS=Mus musculus GN=Eif3j1 PE=2 SV=1 Q4VAE3 5 4 214,98 1,60E-02 751036,55 684421,42 587255,30 583451,01 550451,27 579705,40 440681,20 408759,36 571495,02 Tubulin-specific chaperone A OS=Mus musculus GN=Tbca PE=1 SV=3 Q60634 4 4 81,60 1,98E-02 4182107,60 5239438,58 6832041,46 4638563,78 4119522,60 5228116,82 4061632,25 5288912,70 4443767,05 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Mus musculus GN=Aldh6a1 PE=1 SV=1 Q05BC3 5 4 200,69 2,00E-02 103624,00 107625,76 96296,86 130731,74 154822,84 109473,77 88520,23 89816,10 106212,98 Mitofusin-1 OS=Mus musculus GN=Mfn1 PE=1 SV=3 Q99P30 4 4 173,50 2,02E-02 292942,49 297141,42 343937,67 375610,47 407491,61 329370,62 426588,37 485301,46 489280,89 Sphingomyelin 2 OS=Mus musculus GN=Smpd2 PE=1 SV=1 Q9JMC3 7 4 254,83 2,47E-02 246964,36 253807,62 324023,60 380070,67 384865,88 420402,79 276825,63 307255,96 354147,99 TLD domain-containing protein 1 OS=Mus musculus GN=Tldc1 PE=2 SV=1 Q8BFS6 4 4 244,55 2,61E-02 72786,87 90891,57 79191,83 120412,46 133659,01 135479,14 137926,49 83459,75 125797,68 Protein disulfide-isomerase A3 OS=Mus musculus GN=Pdia3 PE=1 SV=2 P29341 4 4 208,56 2,83E-02 50079,61 110148,83 232171,00 453823,00 271348,11 271711,16 315517,05 188343,77 422927,84 Prostaglandin reductase 2 OS=Mus musculus GN=Ptgr2 PE=1 SV=2 O88545 4 4 154,52 2,84E-02 26903,60 53150,01 74081,73 112589,87 104112,17 101680,22 131801,47 87360,83 84871,96 Selenide, dikinase 1 OS=Mus musculus GN=Sephs1 PE=1 SV=1 Q9Z1Q5 4 4 172,68 3,40E-02 130034,92 135371,10 117387,18 156954,76 146088,80 128071,77 101371,87 80683,19 163639,09 L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3 Q8R010 4 4 266,89 3,63E-02 71048,51 78522,85 82982,08 115839,25 107816,23 125576,04 75720,73 23269,29 81444,01 Inactive -like protein 2 OS=Mus musculus GN=Plcl2 PE=1 SV=2 Q9JLJ2 5 4 187,41 3,98E-02 73431,54 88002,65 71681,77 50129,65 80767,14 74216,17 87905,31 93657,61 104001,77 OS=Mus musculus GN=Stmn1 PE=1 SV=2 P49182 4 4 168,23 4,30E-02 42527,08 41802,80 50577,84 69199,07 52004,43 25935,82 75264,96 21915,58 52367,60 3'(2'),5'-bisphosphate nucleotidase 1 OS=Mus musculus GN=Bpnt1 PE=1 SV=2 Q3URS9 4 4 174,36 4,77E-02 51645,96 38802,39 66013,48 50079,08 46197,33 48757,03 37067,83 55788,83 38868,54 KH domain-containing, RNA-binding, -associated protein 1 OS=Mus musculus GN=Khdrbs1 PE=1 SV=2 Q9WVL3 5 4 201,29 4,95E-02 33038,78 69612,95 56163,44 94064,41 131825,20 113355,48 52138,66 125670,43 68425,63 D-binding protein OS=Mus musculus GN=Gc PE=1 SV=2 P62918 4 4 196,10 5,16E-02 230816,16 275108,93 218531,71 183415,61 195998,36 238385,95 156495,78 168397,34 139019,84 Geranylgeranyl transferase type-2 subunit alpha OS=Mus musculus GN=Rabggta PE=1 SV=1 P17427 7 4 341,43 5,17E-02 56448,85 43773,03 63456,65 69220,67 55880,69 71131,61 60325,32 41610,01 61175,10 Cytochrome c, somatic OS=Mus musculus GN=Cycs PE=1 SV=2 Q811D0 4 4 143,18 5,54E-02 12793,27 10407,79 35519,08 52759,30 46953,11 40629,69 20262,96 25952,83 49175,98 Serine/threonine-protein phosphatase 6 catalytic subunit OS=Mus musculus GN=Ppp6c PE=1 SV=1 Q8BZJ7;Q9QZ73 4 4 247,93 5,60E-02 127934,30 168847,57 134515,94 124409,36 108819,62 94669,36 93712,32 105479,90 122045,54 Calcium/calmodulin-dependent protein kinase type 1 OS=Mus musculus GN=Camk1 PE=1 SV=1 Q921M7;Q8BHZ0 4 4 125,41 5,69E-02 47306,93 60524,58 46096,66 72995,95 68527,19 73395,78 38133,02 33640,00 83188,51 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Mus musculus GN=Gpd2 PE=1 SV=2 Q61239 4 4 108,15 6,38E-02 58776,32 53644,54 54175,49 88767,15 76006,49 91317,90 37048,54 37802,21 72195,79 Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 Q61990;P57722 7 4 335,80 6,54E-02 326744,74 350490,14 420554,59 330198,95 317975,30 313542,07 253805,97 267949,93 335994,86 Alpha-mannosidase 2C1 OS=Mus musculus GN=Man2c1 PE=1 SV=1 P62141;P63087 11 4 495,22 6,71E-02 504257,56 628909,69 716005,93 867176,70 765920,30 846071,79 772155,41 841802,03 736127,76 60S acidic ribosomal protein P0 OS=Mus musculus GN=Rplp0 PE=1 SV=3 P26645 4 4 326,10 6,76E-02 79973,23 108210,06 108591,77 61601,00 96238,09 63842,69 79063,93 54215,08 70607,97 Vacuolar-sorting protein SNF8 OS=Mus musculus GN=Snf8 PE=1 SV=1 Q6P069 4 4 168,73 6,98E-02 295664,07 385554,15 330782,23 244720,07 293257,04 256149,20 290058,70 256398,03 281744,30 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 Q9WV60 4 4 134,89 7,62E-02 99713,81 115975,79 107443,12 157657,51 105883,97 219336,00 156149,57 219111,34 187045,14 OS=Mus musculus GN=Anxa3 PE=1 SV=4 P14148 6 4 239,77 7,66E-02 194349,66 241311,72 260096,45 262034,33 335782,75 341072,58 362637,91 290337,97 237677,38 Echinoderm microtubule-associated protein-like 2 OS=Mus musculus GN=Eml2 PE=1 SV=1 Q9DCB8 4 4 267,37 8,09E-02 473370,07 412549,93 272487,62 308543,07 342623,65 232495,18 299064,47 278100,27 399525,98 28S ribosomal protein S30, mitochondrial OS=Mus musculus GN=Mrps30 PE=1 SV=1 Q9JI75 5 4 209,17 9,34E-02 200598,51 239787,01 366795,91 491962,98 352909,47 420499,05 258264,35 262103,45 356730,69 39S ribosomal protein L38, mitochondrial OS=Mus musculus GN=Mrpl38 PE=1 SV=2 P61222 5 4 208,37 9,98E-02 55017,15 68754,58 68394,29 115216,01 97912,49 77827,08 30140,95 44869,23 91975,36 Lipid droplet-associated hydrolase OS=Mus musculus GN=Ldah PE=1 SV=1 Q06770 5 4 209,96 1,03E-01 130095,35 224541,11 168324,74 99982,19 124057,77 119047,53 202414,85 120844,61 110505,58 Maleylacetoacetate isomerase OS=Mus musculus GN=Gstz1 PE=1 SV=1 Q8BHE8 5 4 210,31 1,05E-01 125413,48 151265,54 166374,58 177077,67 199613,69 189275,82 191992,29 233913,60 222068,94 Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus GN=Hnrnpl PE=1 SV=2 Q9DAR7 4 4 192,42 1,07E-01 33095,20 36051,39 61177,13 49508,42 48387,34 61827,88 37198,30 46897,68 57833,48 EF-hand domain-containing protein D2 OS=Mus musculus GN=Efhd2 PE=1 SV=1 Q3TBW2 4 4 152,15 1,10E-01 143919,21 120692,78 76478,28 72800,88 150015,96 80461,27 57743,51 25868,34 59648,20 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Mus musculus GN=Ndufb9 PE=1 SV=3 P61922 6 4 236,12 1,14E-01 70586,35 68994,64 32191,19 62414,17 30843,43 71391,95 93732,70 62525,04 80751,79 26S protease regulatory subunit 6A OS=Mus musculus GN=Psmc3 PE=1 SV=2 Q9ESL4 4 4 227,37 1,32E-01 86633,44 60521,62 58791,80 123149,17 89005,51 108398,16 38725,35 52653,41 84078,07 40S ribosomal protein S24 OS=Mus musculus GN=Rps24 PE=1 SV=1 Q58A65;Q9ESN9 5 4 231,08 1,36E-01 37893,74 39097,62 21986,73 48200,74 38117,14 42184,88 35549,31 42825,02 39461,12 40S ribosomal protein S17 OS=Mus musculus GN=Rps17 PE=1 SV=2 Q8QZY1 4 4 223,48 1,39E-01 34097,96 34570,90 31705,55 33390,18 35532,16 48427,35 32546,30 42792,81 34292,45 OS=Mus musculus GN=Rpl4 PE=1 SV=3 P97290 4 4 262,56 1,44E-01 275711,42 142569,17 110868,93 171249,05 275698,56 140469,23 165476,21 148656,51 139219,05 Protein disulfide-isomerase A6 OS=Mus musculus GN=Pdia6 PE=1 SV=3 Q5DTJ9 4 4 188,30 1,55E-01 11946,43 10503,14 11701,37 15312,54 4421,40 13586,24 11093,50 6702,60 12817,92 Apolipoprotein A-IV OS=Mus musculus GN=Apoa4 PE=1 SV=3 P24369 6 4 212,77 1,61E-01 288146,60 451439,92 242475,80 259753,35 288324,27 293577,04 251118,71 245995,16 328193,69 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 Q91V16 4 4 97,37 1,62E-01 286765,72 249475,71 202222,99 202604,32 184587,39 164041,71 197847,16 175340,69 173348,25 Laminin subunit alpha-4 OS=Mus musculus GN=Lama4 PE=1 SV=2 P97315 5 4 238,16 1,62E-01 326703,83 429585,58 465215,81 458475,51 339688,53 332250,71 544733,06 343155,38 277103,89 Unconventional myosin-Ic OS=Mus musculus GN=Myo1c PE=1 SV=2 Q9EPC1 5 4 238,12 1,72E-01 108980,76 72738,02 92085,76 129333,13 115955,89 124276,21 129711,20 88168,78 91322,71 Cytoplasmic dynein 1 heavy chain 1 OS=Mus musculus GN=Dync1h1 PE=1 SV=2 Q9CQX2 4 4 228,02 1,79E-01 376430,99 403248,58 557486,27 450254,41 393711,52 442691,62 564522,94 509031,37 269112,16 Cat eye syndrome critical region protein 5 homolog OS=Mus musculus GN=Cecr5 PE=1 SV=1 Q9DAK9 4 4 258,45 1,79E-01 1506889,28 1374773,87 1539696,03 1272467,33 1312505,14 1272784,37 1675875,44 1612797,90 1438831,25 Beta-2-glycoprotein 1 OS=Mus musculus GN=Apoh PE=1 SV=1 P57759 4 4 122,21 1,81E-01 148260,74 148261,87 123433,05 168755,74 153582,80 149340,08 126709,86 82873,55 151290,66 Protein S100-A13 OS=Mus musculus GN=S100a13 PE=1 SV=1 Q80X90 11 4 510,19 1,82E-01 44064,22 45603,56 53304,15 62094,47 64003,60 73646,64 47828,64 60480,89 81246,00 Glutathione S-transferase P 1 OS=Mus musculus GN=Gstp1 PE=1 SV=2 P01864 5 4 270,75 1,91E-01 1644869,80 242909,09 307899,63 423282,38 490782,90 381502,99 1295941,53 376255,78 385608,98 Nucleobindin-1 OS=Mus musculus GN=Nucb1 PE=1 SV=2 Q64516;Q9WU65 4 4 131,95 1,99E-01 72203,60 53328,34 68726,86 57414,93 55428,88 46565,49 79419,65 64631,26 58043,28 Elongation factor 1-delta OS=Mus musculus GN=Eef1d PE=1 SV=3 Q99LY9 6 4 304,71 2,04E-01 951607,83 1339368,10 1313954,92 1019342,90 1197828,74 1145937,51 1674843,42 1642504,95 1021893,40 UPF0317 protein C14orf159 homolog, mitochondrial OS=Mus musculus PE=1 SV=1 Q8K157 4 4 228,01 2,12E-01 180737,85 137259,00 168413,73 194845,01 160684,26 190863,72 106317,50 102707,17 187134,42 SH3 domain-binding glutamic acid-rich-like protein OS=Mus musculus GN=Sh3bgrl PE=1 SV=1 P01872 6 4 364,44 2,12E-01 1750967,93 609076,41 388169,93 717537,78 809743,38 302499,32 1212025,99 442931,51 1133582,20 Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus GN=Iqgap1 PE=1 SV=2 Q8VCI5 4 4 231,51 2,15E-01 95047,64 108487,29 143663,21 144786,96 216035,60 144669,25 111727,87 113805,13 161841,33 BRI3-binding protein OS=Mus musculus GN=Bri3bp PE=1 SV=1 P50516 5 4 266,51 2,18E-01 64435,52 62450,16 92381,85 74229,86 94026,18 111820,51 105437,40 76252,14 104332,72 Vesicle-trafficking protein SEC22b OS=Mus musculus GN=Sec22b PE=1 SV=3 Q3UGC7 4 4 233,45 2,28E-01 232886,86 155221,75 72232,57 57072,33 66421,25 46747,20 112094,96 28247,68 84629,85 -like growth factor-binding protein complex acid labile subunit OS=Mus musculus GN=Igfals PE=1 SV=1 Q64521 4 4 167,22 2,33E-01 48705,50 45515,68 78457,23 81068,80 89869,17 113783,85 26508,02 68786,81 79164,63 ATP-sensitive inward rectifier potassium channel 11 OS=Mus musculus GN=Kcnj11 PE=1 SV=1 P14869 4 4 203,32 2,34E-01 260404,54 217977,52 215112,96 171529,36 200354,26 180377,78 224438,64 197795,97 123576,72 Up-regulated during skeletal muscle growth protein 5 OS=Mus musculus GN=Usmg5 PE=1 SV=1 Q9D8E6 4 4 195,46 2,37E-01 172728,59 218426,27 297031,92 260167,88 272653,39 257625,77 223885,83 240285,98 217606,86 C-terminal-binding protein 1 OS=Mus musculus GN=Ctbp1 PE=1 SV=2 Q9JKF1 5 4 141,29 2,41E-01 31265,04 21981,73 26349,04 31019,85 28457,56 27498,53 21718,52 18460,67 33989,76 39S ribosomal protein L19, mitochondrial OS=Mus musculus GN=Mrpl19 PE=1 SV=1 Q78IK2 5 4 499,36 2,43E-01 12157470,58 9465387,65 11084667,81 10127238,64 11129275,21 10512941,54 15434862,57 12583265,52 8595479,75 XIAP-associated factor 1 OS=Mus musculus GN=Xaf1 PE=1 SV=3 Q9CQ80 4 4 260,61 2,50E-01 51867,46 46828,55 39340,14 54815,21 58312,96 84333,56 65441,00 52420,07 53441,63 /FMN cyclase OS=Mus musculus GN=Tkfc PE=1 SV=1 O08997 4 4 320,47 2,52E-01 1355059,36 1695367,88 1228570,86 1539311,05 1302904,88 965947,82 774968,91 875496,82 1252546,16 Transmembrane emp24 domain-containing protein 4 OS=Mus musculus GN=Tmed4 PE=1 SV=1 Q9WTX6 5 4 171,93 2,53E-01 42114,49 49781,20 47274,82 48710,77 43874,86 65347,25 44369,18 34799,98 32489,82 Sodium/potassium-transporting ATPase subunit beta-1 OS=Mus musculus GN=Atp1b1 PE=1 SV=1 Q8R5J9 4 4 235,13 2,53E-01 594540,46 721795,65 365179,20 491842,96 678988,45 381393,36 411640,79 233612,91 438020,20 CD151 antigen OS=Mus musculus GN=Cd151 PE=1 SV=2 Q8K182 6 4 281,96 2,56E-01 132476,98 25239,00 10900,24 41949,06 43172,18 16236,72 26786,33 15638,09 5008,05 Very-long-chain 3-oxoacyl-CoA reductase OS=Mus musculus GN=Hsd17b12 PE=1 SV=1 Q9EQK5 4 4 154,18 2,61E-01 61256,17 41121,09 78946,33 45832,70 64340,49 73176,85 70510,27 49290,38 71653,21 Homeodomain-only protein OS=Mus musculus GN=Hopx PE=1 SV=1 P02762;B5X0G2 4 4 149,16 2,62E-01 556370,29 105620,40 103576,72 310796,43 168828,05 99394,61 102388,74 43847,03 68310,32 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Mus musculus GN=Ndufs8 PE=1 SV=1 Q9R1P0 6 4 273,77 2,68E-01 440597,78 239119,30 179552,28 180129,67 168804,62 186634,17 225218,26 137016,35 194571,45 Unconventional myosin-Vb OS=Mus musculus GN=Myo5b PE=1 SV=2 Q8K3C3 4 4 231,59 2,76E-01 291602,14 335613,21 265217,32 255967,78 317073,33 357536,06 294163,39 327421,16 331406,56 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Mus musculus GN=Ppp2r1b PE=1 SV=2 Q9WV55 6 4 282,89 2,78E-01 121884,70 157440,27 260623,61 240260,97 168447,11 309284,11 193850,64 295037,35 337446,82 Vacuolar protein-sorting-associated protein 25 OS=Mus musculus GN=Vps25 PE=1 SV=1 Q7TSQ8 5 4 168,46 2,82E-01 384399,91 609254,79 391742,48 363757,83 566837,27 479670,73 691307,01 483019,25 449059,88 Histidine triad nucleotide-binding protein 2, mitochondrial OS=Mus musculus GN=Hint2 PE=1 SV=1 Q811I0 4 4 166,24 2,84E-01 154571,03 142296,12 123080,57 154859,16 153283,50 117822,01 131188,95 92908,52 126073,06 protein 19, mitochondrial OS=Mus musculus GN=Ttc19 PE=1 SV=1 Q91VR5 5 4 166,27 2,91E-01 101307,45 112045,55 71369,78 73162,38 61602,36 87104,13 127914,78 58387,09 76381,27 Coagulation OS=Mus musculus GN=F10 PE=1 SV=1 P02469 8 4 351,67 2,92E-01 34525,47 45194,78 54881,63 57841,89 53125,52 46516,15 37293,98 35664,94 67979,66 Complement component C8 beta chain OS=Mus musculus GN=C8b PE=1 SV=1 Q80W21 14 4 826,39 2,95E-01 502600,72 887046,81 503589,75 510449,63 437411,31 457859,67 388251,67 492662,59 483053,47 Acyl-coenzyme A thioesterase 13 OS=Mus musculus GN=Acot13 PE=1 SV=1 Q99KK7 5 4 274,51 2,95E-01 49689,12 66862,63 54302,55 83552,03 71166,73 77908,30 69146,94 49371,12 83690,84 Acylpyruvase FAHD1, mitochondrial OS=Mus musculus GN=Fahd1 PE=1 SV=2 Q9CPQ3 4 4 269,50 2,95E-01 167534,03 207005,23 235741,63 217829,41 277615,09 217040,98 362267,84 276208,11 209991,96 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Mus musculus GN=Qrsl1 PE=1 SV=1 Q8VE22 4 4 177,11 3,00E-01 83730,67 84050,79 83035,94 74204,55 96877,91 96889,43 58911,59 72373,53 68136,85 Copper transport protein ATOX1 OS=Mus musculus GN=Atox1 PE=1 SV=1 Q9WUR9 4 4 227,50 3,00E-01 679901,84 914688,82 546079,40 624443,22 534324,85 625022,77 506079,96 551590,64 675177,01 Actin, cytoplasmic 1 OS=Mus musculus GN=Actb PE=1 SV=1 P62874 10 4 513,29 3,02E-01 335723,81 325039,21 183855,21 219826,88 195095,77 218674,93 263291,52 233851,35 198190,40 Mitochondrial-processing peptidase subunit beta OS=Mus musculus GN=Pmpcb PE=1 SV=1 Q921H8 11 4 579,18 3,13E-01 590668,49 580731,79 693359,49 615602,81 539234,87 395933,29 488476,77 562810,54 779222,55 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Mus musculus GN=Ndufa6 PE=1 SV=1 P70290 4 4 180,49 3,14E-01 128582,96 139601,12 26115,45 30483,21 27016,44 27727,87 192018,52 17170,23 26974,75 Transmembrane protein 14C OS=Mus musculus GN=Tmem14c PE=1 SV=1 P63328;P48453 5 4 165,16 3,15E-01 56316,62 57153,13 59974,69 74577,23 57040,55 67388,54 54555,80 53645,79 80621,70 Platelet glycoprotein 4 OS=Mus musculus GN=Cd36 PE=1 SV=2 P35979 4 4 214,74 3,19E-01 226857,10 238565,44 217471,70 221525,13 243362,07 229424,21 226974,23 177208,05 170543,64 Citrate lyase subunit beta-like protein, mitochondrial OS=Mus musculus GN=Clybl PE=1 SV=2 Q9JKB3 8 4 523,18 3,28E-01 82789,18 152846,70 131914,39 140775,38 110338,13 142547,06 136160,18 145054,10 179253,70 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 P53996 4 4 201,75 3,29E-01 146176,79 114471,11 132543,64 123321,53 137443,68 117559,58 98669,40 80198,00 134519,47 Hemopexin OS=Mus musculus GN=Hpx PE=1 SV=2 P28656 5 4 169,13 3,29E-01 319146,13 190759,83 282514,29 247556,97 251350,20 200205,77 236110,18 142138,14 290130,81 BolA-like protein 1 OS=Mus musculus GN=Bola1 PE=1 SV=1 P01898 4 4 215,64 3,31E-01 358198,90 58647,88 94895,34 117809,29 116939,22 43593,94 237609,29 40307,72 46642,95 PRA1 family protein 3 OS=Mus musculus GN=Arl6ip5 PE=1 SV=2 Q9QZ23 4 4 295,26 3,33E-01 425238,40 589745,90 493504,53 571565,49 620159,33 540753,86 416431,81 442052,21 619998,75 Elongation factor 1-alpha 1 OS=Mus musculus GN=Eef1a1 PE=1 SV=3 Q9ER00 4 4 206,77 3,44E-01 112646,95 89506,16 95900,90 129129,41 117252,05 106600,12 105607,31 106331,32 140067,69 Endoplasmin OS=Mus musculus GN=Hsp90b1 PE=1 SV=2 O70310 4 4 154,95 3,45E-01 47829,14 53387,52 59751,38 59912,84 67132,87 75325,39 72098,90 61871,06 56878,44 Prostamide/prostaglandin F synthase OS=Mus musculus GN=Fam213b PE=1 SV=1 Q99LD4 5 4 191,35 3,48E-01 97991,45 86257,17 91285,33 93451,25 97700,01 109441,89 101463,88 65098,51 135144,62 Adapter molecule crk OS=Mus musculus GN=Crk PE=1 SV=1 Q9CQF9 4 4 170,17 3,58E-01 140696,85 96782,31 123076,08 143512,43 164049,27 116515,94 131166,56 110903,20 132904,04 Uroporphyrinogen-III synthase OS=Mus musculus GN=Uros PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q8R3B1 4 4 181,45 3,65E-01 15219,07 19807,96 40472,80 35543,63 31587,89 39188,04 13361,90 13627,16 31767,81 NAD(P) transhydrogenase, mitochondrial OS=Mus musculus GN=Nnt PE=1 SV=2 P62814 5 4 222,53 3,67E-01 82519,17 56308,35 65788,87 100564,82 97670,87 88716,01 60576,03 64466,68 130630,97 Mitochondrial fission regulator 1-like OS=Mus musculus GN=Mtfr1l PE=1 SV=1 P54726 5 4 254,63 3,76E-01 569257,48 662046,64 374683,28 341175,31 301157,04 371769,67 543589,81 358778,95 254330,27 Indolethylamine N-methyltransferase OS=Mus musculus GN=Inmt PE=1 SV=1 O08600 5 4 296,28 3,81E-01 326527,59 515433,10 350647,42 416213,79 578638,62 602472,09 453904,08 393331,23 551748,04 Complement component C8 alpha chain OS=Mus musculus GN=C8a PE=1 SV=1 Q9DCL8 4 4 121,81 3,81E-01 163102,18 180511,81 169523,99 186609,85 175384,45 197418,43 125284,81 137886,58 264710,87 Coatomer subunit alpha OS=Mus musculus GN=Copa PE=1 SV=2 P54923 4 4 243,03 3,90E-01 125956,17 281357,71 203485,07 183692,23 241151,44 224239,91 102626,03 185954,81 259367,08 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 Q9D6S7 4 4 271,06 3,99E-01 567888,79 916613,52 421143,01 474119,56 432483,03 466596,35 380586,66 471135,38 537886,55 Glucose-6-phosphate 1-dehydrogenase X OS=Mus musculus GN=G6pdx PE=1 SV=3 P56135 4 4 260,78 3,99E-01 40791017,36 38313058,48 28081797,77 29122356,70 31150685,01 28225099,41 42091175,98 25740407,99 30653143,60 BTB/POZ domain-containing protein 16 OS=Mus musculus GN=Btbd16 PE=4 SV=1 P14206 4 4 243,44 4,04E-01 456477,83 334871,50 433959,95 341654,87 360940,70 455765,72 362723,69 360720,55 263844,50 WD repeat-containing protein 61 OS=Mus musculus GN=Wdr61 PE=1 SV=1 P61079;P61080;Q6ZWY64 4 155,10 4,08E-01 1204533,85 726481,06 704327,19 824550,77 746271,95 905079,57 756153,37 575667,59 846283,66 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dlst PE=1 SV=1 Q62448 4 4 143,90 4,11E-01 31521,64 23963,54 23237,44 39140,57 55394,71 35966,94 24578,24 18363,36 50606,85 Alpha--2 OS=Mus musculus GN=Actn2 PE=1 SV=2 P82348 4 4 213,35 4,35E-01 680060,31 934417,54 584858,62 635883,18 555389,64 609145,43 621129,00 762022,83 675059,74 Peroxiredoxin-1 OS=Mus musculus GN=Prdx1 PE=1 SV=1 P26516 4 4 154,36 4,47E-01 158541,79 143848,52 207885,05 244631,59 168725,63 213775,96 198744,12 160137,22 135507,61 Alpha-centractin OS=Mus musculus GN=Actr1a PE=1 SV=1 Q9CZX8 4 4 134,52 4,51E-01 218591,04 248287,47 229741,72 169170,96 224227,29 245002,03 260811,82 215766,15 194090,80 Thioredoxin domain-containing protein 17 OS=Mus musculus GN=Txndc17 PE=1 SV=1 Q61029 4 4 240,63 4,54E-01 104290,06 113918,01 189443,73 125504,46 152739,63 143218,42 134146,99 93013,13 147061,14 Transitional endoplasmic reticulum ATPase OS=Mus musculus GN=Vcp PE=1 SV=4 P51885 7 4 412,91 4,56E-01 703734,97 610621,90 1175622,49 1021512,76 1289070,85 835251,15 1644783,48 689753,29 1226498,63 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Mus musculus GN=Fkbp1a PE=1 SV=2 Q3UGR5 4 4 173,35 4,82E-01 697313,52 756397,81 714402,72 865012,57 971832,78 927273,78 721959,82 563960,83 1143263,85 Protein S100-A6 OS=Mus musculus GN=S100a6 PE=1 SV=3 P29391;P49945 5 4 376,95 4,84E-01 1786446,46 932257,20 1835526,55 2176764,90 1867371,22 1830517,63 1615358,79 1282849,76 1736334,20 Peroxiredoxin-5, mitochondrial OS=Mus musculus GN=Prdx5 PE=1 SV=2 Q99K51 8 4 339,96 4,92E-01 136755,31 153569,57 149122,38 208028,40 218524,40 160419,70 150778,58 194929,43 182840,08 Sorting nexin-3 OS=Mus musculus GN=Snx3 PE=1 SV=3 Q9CQF4 4 4 284,80 4,93E-01 413935,20 403931,10 267758,05 283955,26 394788,28 357542,05 334870,29 231848,52 304010,19 -1-phosphate guanyltransferase beta OS=Mus musculus GN=Gmppb PE=1 SV=1 P33622 4 4 200,33 5,00E-01 973561,33 185345,85 219635,72 369162,70 412544,44 123373,83 1132869,12 279657,50 552137,43 Major vault protein OS=Mus musculus GN=Mvp PE=1 SV=4 P47791 4 4 218,52 5,03E-01 322123,46 354315,09 292151,13 404731,57 163279,12 181597,25 238794,17 269821,10 355726,50 GTP-binding protein SAR1a OS=Mus musculus GN=Sar1a PE=1 SV=1 Q6NZJ6 4 4 237,86 5,09E-01 52825,17 43875,75 42430,72 27092,79 33955,90 42088,01 23760,46 59058,42 51360,54 C->U-editing enzyme APOBEC-2 OS=Mus musculus GN=Apobec2 PE=1 SV=1 P43883 4 4 159,16 5,10E-01 60325,40 75967,41 80653,83 54221,78 89361,61 82675,97 48454,21 102639,05 94641,84 Pre-mRNA-processing factor 19 OS=Mus musculus GN=Prpf19 PE=1 SV=1 Q9D2R6 4 4 125,09 5,21E-01 402902,24 445607,18 204338,43 260895,72 246126,52 223866,76 329618,62 216689,00 261275,28 Mitochondrial inner membrane protein OXA1L OS=Mus musculus GN=Oxa1l PE=1 SV=1 Q8BZW8 4 4 106,75 5,35E-01 110660,22 98787,06 100179,09 75666,46 92456,82 131093,42 133004,09 109290,62 151340,50 Sarcospan OS=Mus musculus GN=Sspn PE=1 SV=1 Q11136 4 4 143,00 5,39E-01 82344,43 71099,11 84617,74 91554,27 82827,73 98686,33 80555,58 64438,39 104061,15 Transmembrane emp24 domain-containing protein 5 OS=Mus musculus GN=Tmed5 PE=1 SV=1 Q9DB26 4 4 183,30 5,43E-01 47704,37 69687,69 67804,47 133177,65 55534,62 71524,09 77874,75 109544,99 71463,63 Hepatoma-derived growth factor OS=Mus musculus GN=Hdgf PE=1 SV=2 P35980 4 4 240,66 5,46E-01 347219,92 378866,25 317302,41 306223,26 294735,54 335465,97 405393,71 259086,27 254271,63 Major urinary protein 6 OS=Mus musculus GN=Mup6 PE=1 SV=2 Q9R112 4 4 198,91 5,60E-01 110028,26 57588,29 98797,01 93181,66 186108,38 130470,35 127991,76 57410,05 87870,38 Cytochrome c oxidase subunit 7B, mitochondrial OS=Mus musculus GN=Cox7b PE=3 SV=1 Q8VE38 5 4 188,07 5,69E-01 156110,43 180687,17 171610,37 211380,99 209815,41 202173,61 135544,82 211975,07 182746,78 Small integral membrane protein 12 OS=Mus musculus GN=Smim12 PE=3 SV=1 P06909 5 4 312,57 5,75E-01 591101,41 379749,91 254772,25 434663,43 601555,85 383066,28 650762,01 408480,21 186077,21 Persulfide dioxygenase ETHE1, mitochondrial OS=Mus musculus GN=Ethe1 PE=1 SV=2 Q6ZWN5 6 4 203,23 6,03E-01 261703,99 279209,65 280936,14 224527,76 243831,25 265625,89 335046,28 198967,22 198411,23 Leiomodin-2 OS=Mus musculus GN=Lmod2 PE=1 SV=1 Q91WS0 4 4 333,94 6,05E-01 7930225,39 13922015,60 12056509,25 8025175,86 10371750,89 9670408,36 17450005,38 17585019,69 9022983,02 Afamin OS=Mus musculus GN=Afm PE=1 SV=2 P47199 4 4 204,29 6,21E-01 76969,57 151069,98 94835,66 129764,02 154961,04 118665,66 64225,80 133628,25 110725,89 39S ribosomal protein L18, mitochondrial OS=Mus musculus GN=Mrpl18 PE=1 SV=1 P82349 4 4 389,51 6,26E-01 335697,41 388426,68 513845,59 417375,56 431452,75 548458,34 283390,57 575598,89 567985,19 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Mus musculus GN=Ndufb3 PE=1 SV=1 Q91YM4 4 4 149,92 6,27E-01 124334,70 121704,83 123678,42 148759,34 138188,92 91159,30 82296,72 92859,07 126074,52 Prefoldin subunit 2 OS=Mus musculus GN=Pfdn2 PE=1 SV=2 Q8R2Q4 4 4 173,63 6,39E-01 63814,55 49479,80 44466,47 60678,53 63828,55 51923,12 39402,56 52014,01 83613,67 Serine/threonine-protein kinase WNK1 OS=Mus musculus GN=Wnk1 PE=1 SV=2 Q9CZS1 7 4 337,40 6,54E-01 234851,97 257063,29 141316,97 304697,47 433037,29 167031,94 276913,24 234803,54 247400,49 Tensin-2 OS=Mus musculus GN=Tns2 PE=1 SV=1 Q9JIY5 4 4 215,20 6,72E-01 239407,99 296194,48 213611,91 275682,54 290492,82 287218,41 215347,91 203556,69 305215,73 Protein disulfide-isomerase A4 OS=Mus musculus GN=Pdia4 PE=1 SV=3 P12970 4 4 131,12 6,91E-01 180963,93 222403,30 123061,19 152778,82 170869,96 210345,33 174699,65 138694,30 128189,10 Proteasome subunit alpha type-4 OS=Mus musculus GN=Psma4 PE=1 SV=1 Q505F5 4 4 160,40 6,95E-01 54082,05 51471,82 23817,76 20382,90 205928,15 31066,63 19033,50 35675,46 37079,83 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 OS=Mus musculus GN=Ddah2 PE=1 SV=1 O55234 5 4 223,78 7,66E-01 196566,20 174109,65 132986,28 154743,74 151658,93 131388,45 203386,11 144687,86 133604,00 Alpha-actinin-1 OS=Mus musculus GN=Actn1 PE=1 SV=1 P47963 4 4 181,35 7,78E-01 335940,42 356904,70 396463,73 317853,46 382159,98 458026,87 440078,73 398459,45 284537,48 Beta-centractin OS=Mus musculus GN=Actr1b PE=1 SV=1 Q3ULF4 5 4 220,29 8,04E-01 74881,49 77012,21 79805,73 84129,32 69291,12 74373,62 98818,97 58109,70 78188,70 Histone H1.2 OS=Mus musculus GN=Hist1h1c PE=1 SV=2 Q9D8T7 5 4 257,98 8,04E-01 80080,78 133878,58 127329,59 113700,38 95554,29 127140,89 96016,88 145160,42 103227,73 NSFL1 cofactor p47 OS=Mus musculus GN=Nsfl1c PE=1 SV=1 Q9WVB0 4 4 252,20 8,17E-01 131927,56 107652,73 119158,26 186471,17 113514,20 157529,95 95966,67 95504,31 222223,82 Reticulocalbin-2 OS=Mus musculus GN=Rcn2 PE=1 SV=1 Q9WV85 4 4 168,59 8,24E-01 44644,21 59914,74 62639,47 73817,78 64100,36 55984,52 42972,22 55843,92 73520,01 --tRNA ligase, cytoplasmic OS=Mus musculus GN=Wars PE=1 SV=2 Q9D404 4 4 174,64 8,31E-01 198643,80 200635,77 215021,39 246560,94 150559,08 218499,10 112764,19 239849,48 260931,81 Ubiquitin-fold modifier 1 OS=Mus musculus GN=Ufm1 PE=1 SV=1 Q9Z1N5 6 4 213,68 8,33E-01 84502,74 95692,27 103665,13 96100,31 98438,06 119847,19 72146,38 106558,59 106300,93 Matrin-3 OS=Mus musculus GN=Matr3 PE=1 SV=1 Q9DC77 4 4 270,75 8,47E-01 478813,53 490979,87 859240,03 366150,01 501103,49 550222,48 420050,03 371061,62 837338,15 Thioredoxin-like protein 1 OS=Mus musculus GN=Txnl1 PE=1 SV=3 P62242 5 4 216,11 8,59E-01 314467,97 298098,56 284243,91 281189,84 320552,48 286451,82 469318,30 357797,81 239167,70 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 Q80X50 4 4 167,39 8,60E-01 14585,10 18923,44 14819,93 17580,16 18836,87 20351,36 8664,38 26106,80 16378,83 60S ribosomal protein L27 OS=Mus musculus GN=Rpl27 PE=1 SV=2 Q99L43 4 4 244,69 8,61E-01 139653,39 198900,36 227729,11 245437,50 213205,06 139708,16 326111,62 116819,59 147554,30 Platelet endothelial molecule OS=Mus musculus GN=Pecam1 PE=1 SV=1 Q8C3X2 5 4 183,60 8,95E-01 132868,50 169351,97 178979,74 133712,78 192520,36 116188,87 154014,46 163737,76 141540,85 Cytochrome c oxidase subunit 5A, mitochondrial OS=Mus musculus GN=Cox5a PE=1 SV=2 Q9QUH0 4 4 307,09 8,96E-01 560375,63 386542,70 653130,23 674749,14 452257,19 437161,49 763073,65 222085,95 651625,88 Myosin-10 OS=Mus musculus GN=Myh10 PE=1 SV=2 O35864 4 4 240,58 8,96E-01 55989,58 103514,23 93541,55 106398,79 82384,41 94929,03 70967,42 122093,94 83913,08 Protein LZIC OS=Mus musculus GN=Lzic PE=1 SV=1 O55023 5 4 164,48 8,97E-01 306193,71 276803,47 312030,30 371374,53 246827,02 292499,30 330709,60 242944,20 291908,87 UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus GN=Uggt1 PE=1 SV=4 Q61160 4 4 156,52 8,98E-01 130145,47 137926,32 124002,92 236246,83 115173,85 155747,52 238186,23 172941,12 170193,66 39S ribosomal protein L37, mitochondrial OS=Mus musculus GN=Mrpl37 PE=1 SV=1 Q8K3H0 4 4 231,56 9,38E-01 10748,82 32487,81 18606,94 22409,98 10033,98 27021,80 27968,99 14179,25 25495,95 Signal transducer and activator of transcription 5B OS=Mus musculus GN=Stat5b PE=1 SV=1 Q9CZM2 4 4 166,20 9,45E-01 121763,14 149088,26 156101,86 130979,75 144237,46 198757,90 154986,68 176809,41 109345,94 Carbonic anhydrase 1 OS=Mus musculus GN=Ca1 PE=1 SV=4 Q9ESB3 4 4 189,77 9,93E-01 422188,21 270232,59 232824,33 468564,25 232990,56 235844,50 402533,57 422058,34 239158,52 Vesicle-associated membrane protein-associated protein A OS=Mus musculus GN=Vapa PE=1 SV=2 Q9DBG6 4 4 197,61 9,98E-01 134160,64 115792,26 172757,80 120737,63 139430,59 145127,65 209151,82 137761,16 97889,34 Ubiquitin fusion degradation protein 1 homolog OS=Mus musculus GN=Ufd1l PE=1 SV=2 P15105 3 3 214,10 5,77E-04 118126,31 115884,82 93343,09 394786,94 354161,04 247652,29 190765,97 149624,13 236641,88 NAD-dependent protein deacetylase -3 OS=Mus musculus GN=Sirt3 PE=1 SV=2 Q99JY3 3 3 159,04 8,17E-04 232644,31 269867,31 241572,59 426344,89 455382,87 390110,23 266925,19 350939,18 362068,13 Nuclear pore complex protein Nup93 OS=Mus musculus GN=Nup93 PE=1 SV=1 P51855 3 3 123,16 2,38E-03 77635,00 99553,29 79344,81 52980,90 67783,27 49452,61 51472,58 57222,07 65179,60 Methionine aminopeptidase 1 OS=Mus musculus GN=Metap1 PE=1 SV=1 Q3UQ84 3 3 134,96 3,45E-03 34441,00 40921,36 38354,68 79982,53 89263,96 58797,08 47904,07 82438,54 72689,77 Non-POU domain-containing octamer-binding protein OS=Mus musculus GN=Nono PE=1 SV=3 Q8K183 4 3 176,05 9,26E-03 136988,15 140683,66 178332,70 170389,44 168364,32 182147,49 127774,57 144069,13 159718,07 DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 P54869;Q8JZK9 3 3 152,24 9,40E-03 6322,52 4057,10 9074,63 8846,54 11611,84 6480,09 25437,63 244434,39 75800,78 Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus GN=Hnrnpa3 PE=1 SV=1 Q8BU30 3 3 98,07 9,98E-03 72351,31 90491,98 140292,62 282599,59 281873,02 287134,58 129721,29 122581,27 183498,08 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Mus musculus GN=Carkd PE=1 SV=1 Q9WUM4 3 3 160,64 1,23E-02 50884,72 60750,18 107430,02 100579,82 89362,45 139229,78 94368,55 86713,94 84026,79 UPF0568 protein C14orf166 homolog OS=Mus musculus PE=1 SV=1 P56382 3 3 127,58 1,38E-02 11944226,80 10698085,80 11047476,79 9669564,49 9940228,53 10500115,27 12833126,47 13004574,69 10275011,27 Protein C10 OS=Mus musculus GN=Grcc10 PE=1 SV=1 Q505D7;Q8BWR2 4 3 177,78 1,50E-02 267192,94 378772,22 144911,14 452400,65 472445,18 838812,61 564703,74 659801,15 475118,46 PRELI domain-containing protein 2 OS=Mus musculus GN=Prelid2 PE=2 SV=1 O54984 3 3 113,25 1,78E-02 171324,66 175448,19 185020,27 258749,31 296066,29 242300,01 210971,31 150732,18 230924,57 Putative hydroxypyruvate isomerase OS=Mus musculus GN=Hyi PE=1 SV=2 P47754 4 3 165,96 2,04E-02 437827,03 290723,33 223435,54 201068,67 189160,13 159120,75 178824,26 154522,73 209952,32 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Mus musculus GN=Atp1a1 PE=1 SV=1 Q9DBB9 3 3 121,55 2,15E-02 342621,11 192140,97 154909,35 122841,24 104896,16 81568,01 130830,55 34512,43 79294,27 Peptidase M20 domain-containing protein 2 OS=Mus musculus GN=Pm20d2 PE=1 SV=1 Q8R404 3 3 109,99 2,17E-02 3145167,77 4151816,40 4078855,92 4503827,78 5590773,99 5682710,04 6173192,18 5007245,87 5733195,97 B-cell receptor-associated protein 29 OS=Mus musculus GN=Bcap29 PE=1 SV=1 P29788 3 3 161,25 2,37E-02 563863,21 327596,83 260016,31 333442,65 527118,81 246654,86 320028,71 141535,31 149455,19 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Mus musculus GN=Pdpr PE=1 SV=1 Q8VBV7 3 3 172,20 2,44E-02 132199,44 113934,37 232280,91 331707,77 366116,52 311207,97 217755,31 174878,84 394849,26 Required for meiotic nuclear division protein 1 homolog OS=Mus musculus GN=Rmnd1 PE=1 SV=1 Q9DB29 3 3 94,61 2,50E-02 56494,45 57259,60 39560,86 139782,53 138678,31 99848,46 67827,65 51188,74 163144,18 Protein HEG homolog 1 OS=Mus musculus GN=Heg1 PE=1 SV=1 Q5DTH5 3 3 69,50 2,80E-02 70112128,51 47477920,03 66182925,93 49293516,43 34683843,09 28929613,07 10330968,54 25822336,22 27486404,20 Rab GDP dissociation inhibitor beta OS=Mus musculus GN=Gdi2 PE=1 SV=1 Q91YP2 3 3 115,03 2,95E-02 36665,29 60189,03 47200,37 93568,65 110681,12 110339,87 56793,62 88824,22 134408,55 ATP-binding cassette sub-family B member 8, mitochondrial OS=Mus musculus GN=Abcb8 PE=1 SV=1 Q9QZ88 3 3 114,62 3,11E-02 216148,30 245313,55 235560,14 274136,01 242902,23 264011,06 349707,32 291734,69 299766,63 ADP-ribosylation factor-like protein 2 OS=Mus musculus GN=Arl2 PE=1 SV=1 O70400 4 3 220,58 3,59E-02 272624,01 303598,53 294570,23 289213,04 235190,58 238219,72 292512,10 298059,54 269885,16 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Mus musculus GN=Isca1 PE=2 SV=1 Q62433 3 3 160,61 3,71E-02 49447,87 67545,86 70948,12 76496,93 69582,50 80893,34 77379,33 74573,53 92562,45 Ras-related protein Rab-6A OS=Mus musculus GN=Rab6a PE=1 SV=4 Q8BH58 3 3 139,14 3,77E-02 184029,97 234264,19 239150,47 300519,92 291404,90 301404,95 217158,62 203358,11 337265,88 ATP synthase mitochondrial F1 complex assembly factor 1 OS=Mus musculus GN=Atpaf1 PE=1 SV=1 Q91WP6 7 3 438,39 3,82E-02 133246,14 117474,38 26701,32 424367,79 239950,26 224135,37 125074,15 112576,83 103862,46 Alpha-crystallin B chain OS=Mus musculus GN=Cryab PE=1 SV=2 Q9DBH5 3 3 135,37 3,94E-02 102398,45 128773,13 165483,44 194276,03 230535,84 233561,29 170059,72 158699,22 231216,87 Cullin-associated NEDD8-dissociated protein 1 OS=Mus musculus GN=Cand1 PE=1 SV=2 P50285 3 3 65,79 4,13E-02 21611,50 13805,34 19279,12 13433,87 9139,30 20683,93 6004,58 8523,00 11117,80 Raftlin OS=Mus musculus GN=Rftn1 PE=1 SV=4 Q9R1P3 4 3 233,79 4,19E-02 319051,15 332645,21 195783,88 372238,21 354234,56 364677,50 362708,57 296695,28 332708,12 Neutral alpha-glucosidase C OS=Mus musculus GN=Ganc PE=1 SV=2 Q9JJV2 3 3 157,22 4,21E-02 143601,00 171896,51 158627,69 173358,14 174365,16 183435,96 151472,82 158321,51 203415,21 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Mus musculus GN=Clpx PE=1 SV=2 Q80XB4 7 3 263,38 4,73E-02 10446,09 14209,98 12750,01 20655,46 32299,77 20176,17 14742,00 23702,27 23719,91 Cullin-4A OS=Mus musculus GN=Cul4a PE=1 SV=1 Q9QZH6 5 3 286,30 4,73E-02 69108,97 63357,63 70595,92 108714,68 115870,87 86607,89 36822,56 81147,46 48706,88 Phosphatidylethanolamine-binding protein 1 OS=Mus musculus GN=Pebp1 PE=1 SV=3 P55096 5 3 198,23 4,82E-02 75867,44 77682,98 68469,71 129898,24 122852,35 137793,60 79601,35 144269,30 162730,17 Obscurin-like protein 1 OS=Mus musculus GN=Obsl1 PE=1 SV=1 P97370 3 3 117,38 4,97E-02 136533,08 195469,30 187627,60 235316,57 239198,49 246943,87 170393,31 154157,11 207504,66 Cytochrome b-c1 complex subunit 6, mitochondrial OS=Mus musculus GN=Uqcrh PE=1 SV=2 P50580 4 3 260,83 5,03E-02 162009,91 137861,16 153558,75 101712,58 96962,68 119282,40 146106,25 126474,35 100722,64 Cullin-2 OS=Mus musculus GN=Cul2 PE=1 SV=2 O89053 3 3 156,05 5,09E-02 81349,58 61441,83 35539,87 48888,61 78620,78 139890,43 105626,59 58030,79 40405,18 Ethylmalonyl-CoA decarboxylase OS=Mus musculus GN=Echdc1 PE=1 SV=2 O70423 3 3 153,92 5,34E-02 96844,36 88446,32 102231,11 142324,60 99367,98 152735,71 102736,27 99826,42 121959,29 Secernin-3 OS=Mus musculus GN=Scrn3 PE=1 SV=1 Q99020 3 3 228,20 5,78E-02 306579,29 285598,34 357888,72 377924,50 338307,87 412867,63 364774,24 362708,11 366411,28 NLR family member X1 OS=Mus musculus GN=Nlrx1 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

O35206 3 3 133,80 6,15E-02 34347,70 69473,28 86865,98 80484,49 81023,90 77119,44 72659,98 89197,80 85450,84 FAS-associated factor 1 OS=Mus musculus GN=Faf1 PE=1 SV=2 Q60631 3 3 111,85 6,31E-02 32248,96 29651,47 34304,30 15230,65 24970,56 30074,89 27919,50 30236,48 31019,61 Glutathione peroxidase 3 OS=Mus musculus GN=Gpx3 PE=1 SV=2 P60766 3 3 149,57 6,35E-02 205710,35 254893,74 305865,90 183497,33 187388,20 196431,06 193590,48 265998,89 206153,22 Thiosulfate sulfurtransferase OS=Mus musculus GN=Tst PE=1 SV=3 P29595;Q9JJK5 3 3 93,53 6,62E-02 579380,97 349419,17 564929,13 428012,25 373017,55 330979,47 476099,94 376877,84 467901,26 Tumor susceptibility 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2 P19096 4 3 195,53 6,83E-02 11461,41 10520,41 36876,65 13449,41 8545,39 15558,35 17244,53 5492,80 6161,13 Glycophorin-C OS=Mus musculus GN=Gypc PE=1 SV=2 P61211 3 3 127,15 7,07E-02 55762,25 62266,86 57579,45 83825,07 106174,12 106384,65 75290,93 71821,43 104824,99 ATP-dependent RNA helicase DDX1 OS=Mus musculus GN=Ddx1 PE=1 SV=1 P61161 4 3 214,08 7,24E-02 323270,38 355870,86 309501,52 350532,18 327875,01 312335,64 351105,55 241395,25 330579,79 Cytochrome b-c1 complex subunit 7 OS=Mus musculus GN=Uqcrb PE=1 SV=3 Q60973;Q60972 3 3 96,68 7,43E-02 52310,24 40702,73 43147,34 36162,07 29117,09 37372,52 34614,50 35392,34 39344,23 Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Mus musculus GN=Uchl3 PE=1 SV=2 P56812 3 3 222,70 7,63E-02 174125,46 87020,94 147567,74 74413,55 34698,86 61367,90 82015,81 43722,67 152762,99 Translation initiation factor IF-2, mitochondrial OS=Mus musculus GN=Mtif2 PE=1 SV=2 O70373 5 3 183,34 8,18E-02 75049,84 48442,10 43643,98 25582,96 31295,61 36987,28 35079,38 12008,86 37622,12 Laminin subunit beta-1 OS=Mus musculus GN=Lamb1 PE=1 SV=3 P61971 3 3 157,06 8,23E-02 2103674,07 2776045,84 2151739,65 2191019,96 2132486,47 1947214,13 1922246,04 2233128,32 2566236,45 inhibitor 5 OS=Mus musculus GN=Api5 PE=1 SV=2 P03930 3 3 136,38 8,51E-02 5874559,79 5134894,11 4746073,15 4641939,72 4396462,31 5253461,90 5132756,87 5211316,55 6064469,21 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus GN=Hnrnph1 PE=1 SV=3 Q91WK5 3 3 230,50 9,10E-02 1041990,25 1395664,91 626854,39 1039326,77 1053105,42 930717,99 708417,02 710548,00 1191403,43 COP9 signalosome complex subunit 2 OS=Mus musculus GN=Cops2 PE=1 SV=1 P30681 5 3 231,04 9,60E-02 49144,62 77900,26 58155,92 42437,02 53004,74 43719,32 69923,65 48122,11 57265,18 Neudesin OS=Mus musculus GN=Nenf PE=1 SV=1 Q63932 4 3 248,82 1,03E-01 133546,43 138633,32 151119,52 144822,57 179089,88 155983,86 82147,35 103355,26 147685,07 Triadin OS=Mus musculus GN=Trdn PE=1 SV=1 Q8R1Q8 4 3 213,89 1,04E-01 75738,61 62021,55 64884,35 101090,63 107889,98 103065,91 61814,00 92318,84 68985,03 Lysosomal alpha-glucosidase OS=Mus musculus GN=Gaa PE=1 SV=2 Q8BVQ5 3 3 147,13 1,06E-01 19524,17 39413,52 79139,52 75738,06 63696,55 101040,39 34012,24 49493,80 85015,33 Acylphosphatase-2 OS=Mus musculus GN=Acyp2 PE=1 SV=2 Q8BJZ4 6 3 216,31 1,06E-01 94264,90 115097,29 159772,30 206315,12 221494,01 193624,34 56184,46 82771,25 181776,58 Cytochrome P450 2W1 OS=Mus musculus GN=Cyp2w1 PE=2 SV=1 Q920Q6 3 3 155,47 1,06E-01 67106,41 143754,59 103688,48 115750,76 99032,63 124490,71 188143,35 145431,18 157052,63 Glutathione S-transferase Mu 7 OS=Mus musculus GN=Gstm7 PE=1 SV=1 Q9CWK8 6 3 372,40 1,08E-01 30921,34 30941,06 63929,96 89336,95 85679,54 62233,12 27346,37 60449,69 109243,15 Farnesyl pyrophosphate synthase OS=Mus musculus GN=Fdps PE=1 SV=1 P11438 3 3 169,65 1,12E-01 188830,17 228900,10 213848,67 198600,20 202261,87 162783,37 192795,73 139207,50 180775,77 UPF0598 protein C8orf82 homolog OS=Mus musculus PE=1 SV=1 Q9D517 3 3 80,44 1,14E-01 50429,79 88374,27 81068,32 70331,23 95173,05 61354,34 94203,06 123531,65 79722,59 Dipeptidyl peptidase 3 OS=Mus musculus GN=Dpp3 PE=1 SV=2 P59999 3 3 137,27 1,17E-01 187813,14 184168,65 164225,69 211207,12 205586,01 171887,13 131514,73 91907,87 184515,14 S-phase kinase-associated protein 1 OS=Mus musculus GN=Skp1 PE=1 SV=3 O08795 3 3 141,79 1,18E-01 40709,22 36601,14 46465,27 42616,23 50755,51 41404,15 43945,61 36297,93 42521,44 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=1 SV=3 Q9JKF7 4 3 141,30 1,19E-01 41218,19 49273,73 56044,57 84603,50 52335,81 87916,26 36500,59 60662,10 61608,04 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 OS=Mus musculus GN=Ndufa12 PE=1 SV=2 Q61599 3 3 158,77 1,22E-01 286194,24 114230,82 168447,69 128144,63 164840,78 243991,56 172300,35 121065,92 110761,12 40S ribosomal protein S29 OS=Mus musculus GN=Rps29 PE=3 SV=2 P02301 4 3 188,01 1,22E-01 4210194,73 3921420,71 4328791,06 2351216,63 2990127,95 4171284,13 4297722,69 5341407,15 2220676,95 Plasma OS=Mus musculus GN=Klkb1 PE=1 SV=2 P56376 3 3 178,28 1,30E-01 407684,50 659178,15 417805,27 470423,81 377871,55 423051,80 295077,03 244872,09 432663,98 alpha-4 chain OS=Mus musculus GN=Tpm4 PE=1 SV=3 P03888 3 3 146,24 1,31E-01 895072,09 840463,91 1428181,00 1352101,10 1733225,40 1834912,35 1236790,10 1504286,52 1162624,40 ELAV-like protein 1 OS=Mus musculus GN=Elavl1 PE=1 SV=2 Q8CIN4;O88643 3 3 164,49 1,32E-01 26649,78 36656,98 48223,78 55078,51 55567,23 44991,97 61562,20 37695,10 52956,89 14-3-3 protein epsilon OS=Mus musculus GN=Ywhae PE=1 SV=1 Q9R0Q7 3 3 136,04 1,34E-01 512864,43 506206,29 505712,45 465581,19 453635,79 421808,81 374219,42 406317,70 464635,31 LanC-like protein 1 OS=Mus musculus GN=Lancl1 PE=1 SV=1 P97467 3 3 117,96 1,43E-01 28249,01 6886,98 13593,58 19907,94 15256,41 9745,26 38669,29 44633,37 20138,25 3-mercaptopyruvate sulfurtransferase OS=Mus musculus GN=Mpst PE=1 SV=3 Q3THK7 3 3 143,13 1,45E-01 49435,63 68832,76 56792,37 103772,32 109987,95 93161,88 58342,92 63307,47 121405,82 Cullin-associated NEDD8-dissociated protein 2 OS=Mus musculus GN=Cand2 PE=1 SV=2 Q8BGX2 3 3 167,26 1,45E-01 115819,82 77219,84 131043,57 119525,08 122973,57 103257,48 105158,50 100938,81 153743,35 Glycerol-3-phosphate dehydrogenase 1-like protein OS=Mus musculus GN=Gpd1l PE=1 SV=2 Q80VP1;Q91W69 3 3 110,98 1,45E-01 16719,93 33567,71 21377,75 35346,86 26208,36 41832,07 31598,35 29244,82 40711,07 dehydrogenase, mitochondrial OS=Mus musculus GN=Aldh2 PE=1 SV=1 Q80YV4 4 3 106,61 1,50E-01 39084,59 57378,96 63454,34 55614,97 48704,43 53700,99 60649,68 65938,28 70900,50 Hsp90 co-chaperone Cdc37 OS=Mus musculus GN=Cdc37 PE=1 SV=1 P97855 4 3 196,02 1,50E-01 111105,99 164062,68 120701,84 166158,71 177114,01 196094,11 122453,81 130864,82 142068,43 Transcription factor BTF3 OS=Mus musculus GN=Btf3 PE=1 SV=3 Q8BUY5 3 3 167,16 1,54E-01 182546,39 215877,42 127559,87 138679,06 130307,68 107136,72 151838,42 142661,67 144454,51 NADH-ubiquinone oxidoreductase chain 4 OS=Mus musculus GN=Mtnd4 PE=1 SV=1 P15532 8 3 500,02 1,64E-01 1271493,20 1132222,27 1098229,63 1246087,24 1107960,89 1256389,38 1183306,60 1304453,60 1105948,13 BRISC and BRCA1-A complex member 1 OS=Mus musculus GN=Babam1 PE=1 SV=1 Q60675 4 3 208,35 1,79E-01 14157,11 14824,47 10798,08 20535,82 30260,08 16711,65 14660,36 14509,76 14587,30 28S ribosomal protein S23, mitochondrial OS=Mus musculus GN=Mrps23 PE=1 SV=1 P41105 3 3 131,55 1,83E-01 220689,97 221312,63 225242,62 192778,66 191087,42 250381,04 172580,69 240327,82 114929,34 Adenylate kinase 4, mitochondrial OS=Mus musculus GN=Ak4 PE=1 SV=1 Q80YD1 4 3 176,75 1,87E-01 39863,06 44348,71 36699,09 47783,41 52296,59 43790,09 28828,75 30091,70 40063,37 60S ribosomal protein L23 OS=Mus musculus GN=Rpl23 PE=1 SV=1 Q9D8U8;Q6P8X1 3 3 148,83 1,91E-01 71625,54 37062,42 51341,71 60130,49 61020,59 50728,69 51588,16 51176,29 65957,94 Protein O-GlcNAcase OS=Mus musculus GN=Mgea5 PE=1 SV=2 P63001 3 3 101,82 1,93E-01 1811536,94 2146446,13 898225,28 817442,61 819227,08 765705,71 1339808,71 1108208,12 770957,47 Thioredoxin reductase 2, mitochondrial OS=Mus musculus GN=Txnrd2 PE=1 SV=4 P70336 5 3 171,72 1,95E-01 588187,98 647571,17 408712,58 534097,74 659372,93 570294,36 764685,03 625114,02 603192,23 Methylthioribulose-1-phosphate dehydratase OS=Mus musculus GN=Apip PE=1 SV=1 Q9WUA3 6 3 336,45 2,00E-01 45008,33 32721,36 39069,23 46646,44 49361,58 63406,82 35426,83 53458,01 68031,78 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Mus musculus GN=Gnb1 PE=1 SV=3 P61148 3 3 87,40 2,02E-01 146703,70 189533,14 182899,16 130110,95 131001,65 132182,64 108861,17 150491,92 178293,63 Protein phosphatase 1 regulatory subunit 12A OS=Mus musculus GN=Ppp1r12a PE=1 SV=2 Q9CR24 3 3 124,77 2,04E-01 183281,98 179969,01 247360,19 205777,42 181139,04 183157,03 210118,17 239738,24 243769,93 Murinoglobulin-1 OS=Mus musculus GN=Mug1 PE=1 SV=3 Q3U5Q7 4 3 146,29 2,05E-01 54073,31 15364,47 19210,68 36731,19 37722,36 51974,52 33433,57 14294,95 51499,53 Platelet-activating factor acetylhydrolase IB subunit beta OS=Mus musculus GN=Pafah1b2 PE=1 SV=2 Q9Z1G3 3 3 81,21 2,17E-01 24651,52 28844,06 21281,44 26731,47 34866,97 28381,33 27416,50 26591,63 29904,56 Vacuolar protein sorting-associated protein 28 homolog OS=Mus musculus GN=Vps28 PE=1 SV=1 O08759 3 3 197,68 2,19E-01 45894,79 63465,59 38439,69 52403,28 43665,19 36031,76 35958,34 28790,61 44625,88 BAG family molecular chaperone regulator 3 OS=Mus musculus GN=Bag3 PE=1 SV=2 P06330;P01756;P017494 3 294,95 2,20E-01 919817,19 1032390,61 168607,80 390735,03 84429,14 188836,28 857271,02 655191,22 319754,88 Aurora kinase A OS=Mus musculus GN=Aurka PE=1 SV=1 Q8CHH9 5 3 195,41 2,21E-01 60018,82 78307,56 89818,94 76360,90 56936,52 56876,00 50337,96 52703,22 67511,91 Src substrate cortactin OS=Mus musculus GN=Cttn PE=1 SV=2 P62869 3 3 146,06 2,26E-01 81856,96 128689,52 139946,72 105022,65 76773,19 73917,46 107608,16 88481,31 104865,88 ATP synthase subunit g, mitochondrial OS=Mus musculus GN=Atp5l PE=1 SV=1 Q6GQT9 3 3 119,61 2,28E-01 12080,90 8715,15 21864,06 21388,97 25869,69 23659,00 11754,45 9423,54 21918,77 Vesicle-associated membrane protein 2 OS=Mus musculus GN=Vamp2 PE=1 SV=2 P54227;P55821 3 3 128,08 2,31E-01 58160,00 26555,55 71575,67 63233,96 84855,20 55356,00 155206,60 90764,90 57250,36 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Mus musculus GN=Aldh4a1 PE=1 SV=3 Q9Z0S1 3 3 94,41 2,31E-01 52102,81 50736,72 70139,23 82878,70 50775,60 42227,50 27767,49 28433,76 58546,02 OS=Mus musculus GN=Des PE=1 SV=3 Q9JHK4 3 3 136,13 2,32E-01 17235,40 34555,49 29395,65 47991,51 39949,19 53508,63 20319,97 37473,88 50287,61 Selenoprotein P OS=Mus musculus GN=Sepp1 PE=1 SV=3 P47809 3 3 152,39 2,34E-01 82614,31 98976,17 68350,72 80462,08 102853,26 98021,19 35871,03 68433,98 109310,53 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Mus musculus GN=Echdc3 PE=1 SV=1 P62849 3 3 132,68 2,37E-01 102905,13 80494,75 103843,51 88477,25 155719,04 229657,15 234063,44 149905,58 125314,60 Glycogen phosphorylase, muscle form OS=Mus musculus GN=Pygm PE=1 SV=3 P63276 4 3 218,89 2,37E-01 243474,42 222237,79 254589,02 224724,57 285247,40 382925,59 260436,47 226466,45 195095,96 Synaptopodin 2-like protein OS=Mus musculus GN=Synpo2l PE=1 SV=1 Q91WM2 4 3 132,99 2,40E-01 166888,87 129904,57 150470,65 156372,45 274067,12 228143,32 175318,53 171870,71 334515,11 Cytochrome c oxidase subunit 6B1 OS=Mus musculus GN=Cox6b1 PE=1 SV=2 Q9JJU8 3 3 148,23 2,41E-01 304614,68 204364,26 236126,35 216384,27 119329,76 155407,04 226527,07 186308,27 215634,38 Translocon-associated protein subunit alpha OS=Mus musculus GN=Ssr1 PE=1 SV=1 O08547 3 3 136,25 2,42E-01 94378,93 113380,05 81287,99 104512,99 69054,45 83861,46 72466,95 77927,31 72751,39 Proteasome subunit alpha type-5 OS=Mus musculus GN=Psma5 PE=1 SV=1 O88712 3 3 143,20 2,43E-01 91682,93 79529,15 92110,31 101403,37 109328,29 109364,94 90833,03 95752,12 104342,38 Peptidyl-tRNA hydrolase ICT1, mitochondrial OS=Mus musculus GN=Ict1 PE=1 SV=1 Q9D338 3 3 115,17 2,43E-01 115648,89 102889,67 95797,41 119939,58 136297,78 129873,23 111329,77 98456,42 107684,82 Alpha-adducin OS=Mus musculus GN=Add1 PE=1 SV=2 Q9CZN8 3 3 169,84 2,52E-01 651870,88 797881,98 697703,29 563259,08 652271,39 566151,57 619263,98 607796,66 613496,21 Methionine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Mars PE=1 SV=1 O70492 5 3 144,23 2,60E-01 111409,06 160586,45 153674,88 130690,62 149409,36 154568,25 112494,20 95688,90 179650,13 Mitochondrial import and assembly protein 40 OS=Mus musculus GN=Chchd4 PE=1 SV=1 Q8BGA9 3 3 110,92 2,61E-01 113980,86 158458,87 144312,27 108172,44 123253,37 108233,81 194548,54 140960,00 106399,76 Reticulon-4 OS=Mus musculus GN=Rtn4 PE=1 SV=2 O70591 3 3 149,41 2,67E-01 46592,83 19372,78 54172,86 55557,23 69904,68 38395,74 21309,45 31469,19 65982,86 U6 snRNA-associated Sm-like protein LSm4 OS=Mus musculus GN=Lsm4 PE=1 SV=1 Q8K310 4 3 115,11 2,73E-01 27996,55 45047,06 26879,78 28781,44 33800,81 51150,79 43008,05 56480,22 35945,68 Cytochrome c oxidase subunit NDUFA4 OS=Mus musculus GN=Ndufa4 PE=1 SV=2 Q6IR34 3 3 203,60 2,74E-01 81396,56 109723,37 92116,21 141970,65 160153,73 165171,17 69307,82 71481,50 173645,15 Triosephosphate isomerase OS=Mus musculus GN=Tpi1 PE=1 SV=4 Q6P5E4 3 3 176,70 2,76E-01 706118,49 780449,85 626688,66 860481,71 1394888,74 642711,50 825705,25 254462,66 601380,78 Inosine triphosphate pyrophosphatase OS=Mus musculus GN=Itpa PE=1 SV=2 Q8R104 3 3 146,48 2,78E-01 107060,27 105279,05 95195,67 106801,50 153147,12 95315,22 65266,89 83934,30 118394,87 V-type proton ATPase subunit G 1 OS=Mus musculus GN=Atp6v1g1 PE=1 SV=3 Q9CQE8 3 3 174,79 2,80E-01 48023,76 35228,80 31723,79 49111,13 58018,79 82942,04 38891,50 17805,32 42692,40 OS=Mus musculus GN=Rps2 PE=1 SV=3 A3KG59 3 3 103,70 2,81E-01 20777,86 50475,65 107611,98 76267,82 76113,60 124206,18 33287,31 103935,62 126713,96 Protein SGT1 homolog OS=Mus musculus GN=Sugt1 PE=1 SV=3 P35279;P61294 5 3 228,57 2,84E-01 178460,97 227684,76 147803,37 134450,02 141622,65 211041,79 188597,71 162292,36 156197,98 Peptidyl-prolyl cis-trans isomerase-like 2 OS=Mus musculus GN=Ppil2 PE=1 SV=2 Q9JHS4 3 3 98,35 2,86E-01 12618,28 22673,27 32437,89 25704,21 32555,10 26648,48 30540,54 22316,60 40249,94 Arsenite methyltransferase OS=Mus musculus GN=As3mt PE=1 SV=2 Q3TL44 4 3 152,90 2,89E-01 64463,46 134013,98 91533,40 129922,99 127979,91 109212,05 72645,33 70122,74 101215,78 3-ketoacyl-CoA A, peroxisomal OS=Mus musculus GN=Acaa1a PE=1 SV=1 Q920E5 4 3 132,99 2,95E-01 33474,63 28877,76 40675,58 39668,44 45466,27 47934,51 20965,20 15998,79 60121,66 Protein CutA OS=Mus musculus GN=Cuta PE=1 SV=3 Q9WTX5 4 3 186,49 2,95E-01 264481,13 201756,53 253325,85 209615,06 175028,67 208440,88 181719,23 137143,03 222854,76 4 OS=Mus musculus GN=Myl4 PE=1 SV=3 P39655 3 3 149,29 3,22E-01 54395,81 58798,48 14270,52 22049,53 36687,61 111499,65 61539,64 52689,69 20008,01 55 kDa erythrocyte membrane protein OS=Mus musculus GN=Mpp1 PE=1 SV=1 Q9Z0V8 3 3 167,04 3,36E-01 19558,35 35792,31 30706,18 36152,82 54585,57 55311,00 51543,89 42016,57 51908,12 Actin-related protein 2/3 complex subunit 2 OS=Mus musculus GN=Arpc2 PE=1 SV=3 Q60668 4 3 207,08 3,42E-01 391461,23 401519,49 477508,41 517117,94 516719,59 550819,67 414413,32 448661,38 513380,26 Twinfilin-2 OS=Mus musculus GN=Twf2 PE=1 SV=1 P49817;P51637 5 3 209,15 3,43E-01 1157705,06 650929,27 901988,47 575516,11 582059,83 529216,56 1292736,90 812080,68 340057,58 Dehydrogenase/reductase SDR family member 4 OS=Mus musculus GN=Dhrs4 PE=1 SV=3 Q9JKL4 3 3 176,44 3,46E-01 273929,78 458370,41 388722,18 496886,56 483625,20 474917,20 315373,29 410044,28 521845,97 Alpha--stabilizing protein OS=Mus musculus GN=Ahsp PE=1 SV=1 Q9JKV1 3 3 180,82 3,47E-01 73216,80 77780,42 77306,08 63497,69 59395,94 61518,28 95037,87 71533,46 62168,16 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Mus musculus GN=Ppp3ca PE=1 SV=1 Q9CQD1 6 3 334,47 3,55E-01 154425,20 123638,53 112607,54 132448,71 138698,18 109578,40 137856,73 98273,60 125770,00 Leucine-rich PPR motif-containing protein, mitochondrial OS=Mus musculus GN=Lrpprc PE=1 SV=2 Q9ERG2 3 3 103,49 3,65E-01 38997,22 49582,06 31588,23 34296,13 38286,44 29324,52 35790,35 30041,73 44689,30 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Mus musculus GN=Cpt2 PE=1 SV=2 Q9D1G1;P61028;Q8K386;P5637110 3 595,04 3,76E-01 1252543,89 1332449,66 881364,26 1144284,76 1317956,52 1161433,91 877482,62 1061034,78 1265061,30 Probable D-lactate dehydrogenase, mitochondrial OS=Mus musculus GN=Ldhd PE=1 SV=1 P60229 3 3 152,36 3,83E-01 12152,89 62291,83 65985,81 52495,34 56386,33 85879,89 99063,42 75466,29 61063,15 Glycerophosphodiester phosphodiesterase domain-containing protein 1 OS=Mus musculus GN=Gdpd1 PE=1 SV=1 Q9JIF7 5 3 134,37 3,86E-01 17420,95 33600,91 24791,69 30661,21 32493,53 28751,93 20343,72 27953,83 44194,46 60S ribosomal protein L12 OS=Mus musculus GN=Rpl12 PE=1 SV=2 Q9CQ22 3 3 130,99 3,88E-01 20284,93 39764,80 34968,39 36499,02 70245,38 58408,74 28732,23 43646,00 70949,91 Hemoglobin subunit alpha OS=Mus musculus GN=Hba PE=1 SV=2 Q61937 5 3 292,62 3,90E-01 392539,93 445039,30 474123,14 427989,01 394813,52 520382,76 360142,55 313917,89 396004,04 Calcium-regulated heat stable protein 1 OS=Mus musculus GN=Carhsp1 PE=1 SV=1 Q8BJY1 3 3 150,51 3,92E-01 30292,62 19325,68 25996,23 30733,87 18074,22 23990,08 26020,85 9925,73 16825,23 Arachidonate 12-lipoxygenase, 12S-type OS=Mus musculus GN=Alox12 PE=1 SV=4 Q01405 5 3 281,49 3,94E-01 48266,60 22825,80 69886,66 50767,84 76227,78 81991,55 70740,47 42103,91 89708,57 26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus GN=Psmd12 PE=1 SV=4 P61014 4 3 268,42 4,01E-01 20792308,77 23218180,64 14620234,06 13522790,43 15950473,36 16404450,80 18064483,91 16575639,57 14883353,38 Histone-lysine N-methyltransferase Smyd1 OS=Mus musculus GN=Smyd1 PE=1 SV=3 Q9CQC9 4 3 173,47 4,01E-01 475482,84 855955,41 628881,43 568426,09 958684,43 470556,65 499688,88 448792,23 457301,62 MICOS complex subunit Mic27 OS=Mus musculus GN=Apool PE=1 SV=1 Q99JX3 3 3 179,74 4,05E-01 19830,93 41289,63 45269,60 36586,75 51772,49 57089,41 19745,36 46010,59 62441,38 2 OS=Mus musculus GN=Ryr2 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P00493 3 3 141,54 4,11E-01 80260,72 94208,26 100172,46 95274,72 89636,89 74211,52 63091,58 108225,26 154401,44 SH3 domain-containing kinase-binding protein 1 OS=Mus musculus GN=Sh3kbp1 PE=1 SV=1 Q6PHN9 6 3 262,17 4,13E-01 67552,48 76235,96 60882,97 47244,40 34132,88 51538,29 117088,79 67244,46 30105,16 Mitochondrial pyruvate carrier 1 OS=Mus musculus GN=Mpc1 PE=1 SV=1 P05132 10 3 490,42 4,20E-01 618263,78 726437,98 700812,88 672707,48 563085,84 620133,33 688768,42 575307,83 584517,00 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Mus musculus GN=Hs3st3a1 PE=2 SV=1 P47968 3 3 125,77 4,24E-01 41421,63 38748,83 18935,09 34565,44 40471,82 37695,46 53614,11 28293,92 40114,66 Protein S100-A1 OS=Mus musculus GN=S100a1 PE=1 SV=2 P10922 4 3 133,34 4,43E-01 324051,72 307731,80 219764,18 165044,28 205656,67 293937,15 180816,83 287906,45 133154,92 60S ribosomal protein L34 OS=Mus musculus GN=Rpl34 PE=1 SV=2 Q91V12 3 3 101,48 4,59E-01 115984,72 187043,23 99992,94 143463,54 96255,11 223334,30 136280,87 151360,81 166266,42 Transcription termination factor 2, mitochondrial OS=Mus musculus GN=Mterf2 PE=1 SV=1 Q8C5Q4 3 3 146,09 4,60E-01 53959,22 76749,04 69083,72 76608,67 85325,38 71127,89 45371,75 49460,67 90808,97 ADP-ribosylation factor 6 OS=Mus musculus GN=Arf6 PE=1 SV=2 Q9D358 4 3 279,27 4,60E-01 276364,17 275755,09 301743,21 248977,20 285179,68 167270,40 603530,76 320242,32 361249,14 C, slow skeletal and cardiac muscles OS=Mus musculus GN=Tnnc1 PE=1 SV=1 P83882 3 3 83,75 4,69E-01 63165,04 53058,28 51802,59 41945,63 35654,53 52744,66 79949,59 81225,00 25497,29 Lymphatic vessel endothelial hyaluronic acid receptor 1 OS=Mus musculus GN=Lyve1 PE=1 SV=1 Q9CR00 3 3 128,78 4,70E-01 137973,22 109851,65 45819,19 76359,73 96875,35 108254,11 97382,92 29036,51 81816,19 PGC-1 and ERR-induced regulator in muscle protein 1 OS=Mus musculus GN=Perm1 PE=1 SV=2 O70251 5 3 293,35 4,74E-01 601846,00 983761,37 713846,78 989719,60 958024,25 978538,05 803073,47 588533,17 928431,10 Nck-associated protein 1 OS=Mus musculus GN=Nckap1 PE=1 SV=2 Q61387 3 3 209,97 4,74E-01 876106,91 924134,11 683732,77 945312,46 1120174,46 454467,15 2194586,92 1297699,66 730098,48 OS=Mus musculus GN=Gsn PE=1 SV=3 Q8C0C7 3 3 132,86 4,75E-01 16694,15 16380,83 22134,33 21267,87 21002,55 37554,85 11476,68 28291,63 28811,47 Myeloid-associated differentiation marker OS=Mus musculus GN=Myadm PE=1 SV=2 D3Z7P3 3 3 214,50 4,76E-01 50881,52 42685,72 61150,42 43554,76 53971,82 34909,42 32816,59 99137,02 79947,40 T-complex protein 1 subunit epsilon OS=Mus musculus GN=Cct5 PE=1 SV=1 Q8BP67 3 3 154,95 4,91E-01 193566,11 231763,15 152602,50 139951,79 191952,63 204994,21 177287,42 135131,05 138781,80 Wolframin OS=Mus musculus GN=Wfs1 PE=1 SV=1 Q9CQN7 3 3 112,28 4,98E-01 125280,97 194765,98 150463,80 142247,08 171503,41 151872,57 176387,18 107452,01 149323,63 Y-box-binding protein 3 OS=Mus musculus GN=Ybx3 PE=1 SV=2 O70362 5 3 227,77 5,11E-01 91260,50 31978,88 23528,73 40661,24 38276,51 11048,87 57669,79 30557,22 38984,09 Cellular nucleic acid-binding protein OS=Mus musculus GN=Cnbp PE=1 SV=2 Q9JHU2 4 3 148,59 5,16E-01 148628,12 232098,43 137146,79 209306,72 236887,25 168386,75 125014,52 137319,80 168434,03 Nucleosome assembly protein 1-like 1 OS=Mus musculus GN=Nap1l1 PE=1 SV=2 Q9R0P9 4 3 176,74 5,20E-01 283719,76 296952,57 683406,45 242227,48 322322,97 182580,51 234688,24 251637,50 534462,63 Thrombospondin-1 OS=Mus musculus GN=Thbs1 PE=1 SV=1 Q80Y14 3 3 274,80 5,28E-01 1284830,01 910975,78 736534,05 985197,64 1149655,03 969073,35 794173,65 558813,30 1109236,47 Diphosphoinositol polyphosphate phosphohydrolase 3-alpha OS=Mus musculus GN=Nudt10 PE=1 SV=1 Q8BU85 3 3 185,08 5,32E-01 104632,69 75048,49 123448,12 96330,40 125948,89 109349,94 74856,11 97285,75 121631,96 5-demethoxyubiquinone hydroxylase, mitochondrial OS=Mus musculus GN=Coq7 PE=1 SV=3 Q64339 3 3 125,11 5,34E-01 461162,44 396715,07 139010,87 154112,66 62775,16 155153,44 1062490,72 99559,96 89489,62 Transmembrane protein 143 OS=Mus musculus GN=Tmem143 PE=1 SV=1 P47757 4 3 156,83 5,34E-01 157461,70 76016,79 95430,41 104796,94 107078,29 95980,70 160427,98 86462,17 138098,47 H-2 class I histocompatibility antigen, Q10 alpha chain OS=Mus musculus GN=H2-Q10 PE=1 SV=3 P84099 4 3 211,65 5,37E-01 367582,25 414023,02 353597,83 341218,64 325443,81 358852,65 415049,96 298708,27 249199,84 Actin-related protein 2/3 complex subunit 5 OS=Mus musculus GN=Arpc5 PE=1 SV=3 P62071 5 3 268,87 5,39E-01 342575,13 349818,59 540471,24 486147,40 391835,45 530235,54 467911,07 592370,27 535975,25 Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1 Q9CPX8 3 3 122,16 5,43E-01 2004379,55 1683497,91 2942698,93 2374091,72 2886660,53 3218573,66 2983972,02 2523721,43 2106268,49 OS=Mus musculus GN=Rps7 PE=2 SV=1 Q7TMB8 4 3 94,45 5,48E-01 314221,61 334471,32 99888,33 162229,89 134392,34 186677,44 232180,16 160767,62 104170,18 OS=Mus musculus GN=Rpl6 PE=1 SV=3 Q8BRK8;Q5EG47 3 3 228,79 5,49E-01 129486,32 146023,11 138048,24 132371,43 151117,44 160247,47 94077,85 134813,23 144375,22 Cathepsin D OS=Mus musculus GN=Ctsd PE=1 SV=1 Q9D1I5 3 3 191,56 5,58E-01 923055,96 1037574,23 582982,69 958460,89 1070324,46 826773,78 662640,46 537261,83 1156764,99 Cytochrome c oxidase protein 20 homolog OS=Mus musculus GN=Cox20 PE=1 SV=1 Q9WV98 3 3 143,66 5,63E-01 252932,62 284717,80 157641,50 198605,67 186380,42 175843,75 181848,30 154066,12 207974,44 Synaptosomal-associated protein 23 OS=Mus musculus GN=Snap23 PE=1 SV=1 B1AR13 3 3 127,76 5,69E-01 126497,36 150599,14 120233,64 90231,55 119052,05 138279,26 106476,33 133774,35 143321,28 Bifunctional purine biosynthesis protein PURH OS=Mus musculus GN=Atic PE=1 SV=2 Q9QVP4 3 3 231,31 5,74E-01 135477,11 159195,58 708659,29 220125,09 231332,65 240168,21 749408,71 419154,89 290782,47 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Mus musculus GN=Nfu1 PE=1 SV=2 Q6PD03 3 3 197,07 5,75E-01 57640,52 68981,33 112544,45 79378,00 66041,49 92913,54 64816,37 73328,43 75600,05 Methyl-CpG-binding protein 2 OS=Mus musculus GN=Mecp2 PE=1 SV=1 Q9Z126 3 3 146,50 5,76E-01 332677,30 172617,66 47722,22 64129,49 166702,96 616085,61 217538,42 389075,94 54094,39 Mitochondrial import inner membrane translocase subunit Tim17-A OS=Mus musculus GN=Timm17a PE=1 SV=1 O35593 3 3 175,81 5,82E-01 155642,62 157185,44 115940,99 152948,67 145851,04 131967,17 131037,29 102384,81 175171,46 Cytosolic non-specific OS=Mus musculus GN=Cndp2 PE=1 SV=1 P11930 3 3 133,15 5,83E-01 17565,48 34141,84 20173,31 37069,25 45085,89 25607,48 18284,58 16727,12 38671,62 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Mus musculus GN=Hibadh PE=1 SV=1 A2AGT5 4 3 147,41 5,89E-01 16010,12 18850,58 21896,20 18221,18 19919,79 27923,01 15966,48 14230,27 22655,08 60S ribosomal protein L39 OS=Mus musculus GN=Rpl39 PE=3 SV=2 Q9CYZ2 4 3 249,81 5,92E-01 310510,23 219101,44 188007,43 256683,00 245037,26 199733,91 222436,21 143301,34 267280,41 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Mus musculus GN=Trnt1 PE=1 SV=1 P34022 3 3 116,90 5,93E-01 638509,55 540797,75 331713,15 434061,20 387433,86 405834,28 666048,21 340441,21 435045,55 Band 3 anion transport protein OS=Mus musculus GN=Slc4a1 PE=1 SV=1 Q9D7X8 4 3 214,11 5,93E-01 105463,61 124376,61 96971,37 140365,00 97246,01 146383,38 60377,55 175788,73 145499,25 Tyrosine--tRNA ligase, mitochondrial OS=Mus musculus GN=Yars2 PE=1 SV=2 Q9D7P6 4 3 193,66 5,95E-01 141867,17 66516,03 154341,86 143954,03 106999,83 110986,13 115323,84 134405,07 175817,72 Heat shock protein beta-8 OS=Mus musculus GN=Hspb8 PE=1 SV=1 P62751 3 3 149,83 6,04E-01 420308,20 403650,59 258053,09 245999,14 260488,09 318991,64 521889,12 259408,23 217464,87 Zinc transporter 9 OS=Mus musculus GN=Slc30a9 PE=1 SV=2 D3Z6Q9 4 3 249,72 6,09E-01 18127,45 11891,02 4308,71 3470,44 8623,34 18209,25 13242,18 11256,98 2390,25 Heat shock protein beta-1 OS=Mus musculus GN=Hspb1 PE=1 SV=3 O08579 3 3 125,17 6,10E-01 30402,25 43617,56 32375,23 42113,84 34930,02 57052,85 32952,91 57688,53 49512,66 Elongation factor 1-gamma OS=Mus musculus GN=Eef1g PE=1 SV=3 Q9CX86 3 3 113,77 6,12E-01 77277,96 100290,84 92346,67 72129,62 98846,35 81541,88 51097,33 139318,09 128712,12 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 Q3THS6 3 3 142,36 6,17E-01 94882,40 113438,72 114767,91 122146,92 109492,25 114180,49 95830,52 133880,29 108200,58 Surfeit locus protein 4 OS=Mus musculus GN=Surf4 PE=1 SV=1 Q61249;Q9QZ29 5 3 267,26 6,25E-01 51926,75 122732,83 42157,92 43878,13 32188,58 74548,33 45185,03 33774,83 55110,23 26S protease regulatory subunit 6B OS=Mus musculus GN=Psmc4 PE=1 SV=2 P47758 3 3 199,32 6,27E-01 17350,29 30858,12 29007,15 32951,60 29210,15 30060,07 19012,16 11862,36 33402,83 Prolyl OS=Mus musculus GN=Prep PE=1 SV=1 Q8R123 4 3 166,65 6,36E-01 67491,84 72650,61 86724,00 91620,40 96291,74 118037,44 51871,58 57680,78 165395,12 Laminin subunit gamma-1 OS=Mus musculus GN=Lamc1 PE=1 SV=2 Q64726 3 3 117,50 6,44E-01 188314,70 49647,49 44746,37 115330,71 114234,41 49657,87 239525,90 27297,33 111469,90 Heterogeneous nuclear ribonucleoprotein D0 OS=Mus musculus GN=Hnrnpd PE=1 SV=2 P32067 3 3 157,90 6,52E-01 26325,94 29339,56 27172,04 25999,41 26336,42 32224,89 31478,28 26031,10 28381,04 -1 OS=Mus musculus GN=Cav1 PE=1 SV=1 P61021 4 3 225,63 6,56E-01 79323,79 122705,20 78485,71 67351,11 121509,50 86443,84 95103,76 79313,07 83555,02 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Mus musculus GN=Nmnat3 PE=1 SV=1 Q91Z83 93 3 5881,78 6,78E-01 661,03 1880,11 2837,43 1014,59 6260,97 12198,69 1486,71 19034,72 2225,82 Rab GDP dissociation inhibitor alpha OS=Mus musculus GN=Gdi1 PE=1 SV=3 Q08091 3 3 161,92 6,78E-01 37506,70 27919,60 31128,64 141049,04 18900,72 23144,31 56328,28 15348,56 29153,52 Ubiquitin-like protein 5 OS=Mus musculus GN=Ubl5 PE=1 SV=1 Q6ZWY3 3 3 154,64 6,87E-01 183604,01 198376,22 128445,25 149144,50 126265,32 201676,13 199110,22 109245,01 114148,23 Calcium-binding mitochondrial carrier protein Aralar1 OS=Mus musculus GN=Slc25a12 PE=1 SV=1 Q6P5F9 4 3 152,26 6,92E-01 94565,88 48091,97 78787,18 64507,67 58419,21 71399,52 64353,53 86781,53 83379,71 Eukaryotic translation initiation factor 5 OS=Mus musculus GN=Eif5 PE=1 SV=1 P08074 6 3 150,74 6,97E-01 68106,20 93449,08 128100,13 130683,62 129166,42 63916,14 116535,88 62101,99 81217,72 Syntaxin-12 OS=Mus musculus GN=Stx12 PE=1 SV=1 Q9DBB8 3 3 175,63 7,15E-01 120599,32 152344,78 262033,56 138799,54 99231,02 173121,24 125319,84 168524,22 228638,14 Glycylpeptide N-tetradecanoyltransferase 1 OS=Mus musculus GN=Nmt1 PE=1 SV=1 O70435 5 3 189,96 7,16E-01 236289,37 242190,84 230364,67 227915,22 223532,52 180530,33 314052,68 198078,99 215691,31 AP-1 complex subunit beta-1 OS=Mus musculus GN=Ap1b1 PE=1 SV=2 Q03734 11 3 785,75 7,28E-01 2061785,24 540049,05 1391207,09 1542667,41 1866756,30 1240688,58 3117796,88 316077,55 600720,70 Erythrocyte membrane protein band 4.2 OS=Mus musculus GN=Epb42 PE=1 SV=3 Q91Y97 3 3 180,62 7,41E-01 34533,09 17378,95 16154,31 22343,49 26988,78 36269,79 44525,69 17892,64 33112,21 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Mus musculus GN=Ndufaf3 PE=1 SV=1 Q8CJ53 3 3 119,11 7,59E-01 35815,05 41246,74 34111,58 54518,92 51900,48 38065,29 32071,79 25906,18 60002,21 Adenylyl cyclase-associated protein 1 OS=Mus musculus GN=Cap1 PE=1 SV=4 Q91YE8 3 3 138,39 7,65E-01 12076,39 13091,94 15570,56 16887,28 15746,77 22927,78 15148,44 41794,49 8508,76 Proteasomal ubiquitin receptor ADRM1 OS=Mus musculus GN=Adrm1 PE=1 SV=2 P35283 4 3 192,28 7,74E-01 123647,68 109541,30 81972,75 79077,44 83028,87 119457,63 64239,23 131567,30 102225,43 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 Q9JJL8 5 3 157,29 7,79E-01 25108,26 30433,57 68296,08 53105,29 37777,86 38765,38 20668,66 43362,54 41128,32 SAP domain-containing ribonucleoprotein OS=Mus musculus GN=Sarnp PE=1 SV=3 P68033;P62737;P6326827 3 2261,69 7,93E-01 34826358,66 33248913,55 30133690,90 19688801,61 29676433,99 22255601,61 48337659,16 46426915,47 14442537,80 Enoyl-CoA delta isomerase 1, mitochondrial OS=Mus musculus GN=Eci1 PE=1 SV=2 Q8JZN7 4 3 162,93 8,06E-01 43471,55 26877,55 39631,83 31693,32 41461,32 49916,15 26476,54 24625,97 50846,49 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Mus musculus GN=Hnrnpa2b1 PE=1 SV=2 Q9DAW9 5 3 289,59 8,06E-01 76848,40 35451,44 48446,55 52830,73 31957,08 44483,53 43187,31 54219,62 48951,23 COP9 signalosome complex subunit 1 OS=Mus musculus GN=Gps1 PE=1 SV=1 Q9D6K8 5 3 235,98 8,10E-01 467770,52 685463,04 794175,85 764451,37 636105,75 604928,18 498579,86 771418,30 669913,61 CDGSH iron-sulfur domain-containing protein 2 OS=Mus musculus GN=Cisd2 PE=1 SV=1 O08583;Q9JJW6 3 3 91,20 8,11E-01 110396,08 211800,19 141206,41 160411,00 147690,69 184657,87 133897,44 121003,06 184511,63 PWWP domain-containing protein 2A OS=Mus musculus GN=Pwwp2a PE=2 SV=2 Q8K3A0 3 3 222,21 8,13E-01 82747,30 120814,99 163722,73 166075,58 119575,43 130577,98 58729,98 131447,43 127953,57 Pyroglutamyl-peptidase 1 OS=Mus musculus GN=Pgpep1 PE=1 SV=1 P62073 4 3 168,06 8,20E-01 401859,42 468284,91 428462,48 370910,20 416401,96 410861,77 364337,38 349650,36 492550,44 Mitochondrial amidoxime reducing component 2 OS=Mus musculus GN=Marc2 PE=1 SV=1 Q02013 4 3 274,71 8,28E-01 673509,36 458550,29 479519,45 295573,32 419786,11 453968,71 1138733,37 440779,15 267584,03 Eukaryotic translation initiation factor 3 subunit A OS=Mus musculus GN=Eif3a PE=1 SV=5 Q9D8B4 3 3 158,26 8,30E-01 2563144,75 2461085,86 2475222,19 2132229,73 2393605,88 1874416,44 3779278,13 2052008,72 1674486,82 6.8 kDa mitochondrial proteolipid OS=Mus musculus GN=Mp68 PE=1 SV=1 P09813 4 3 218,16 8,38E-01 4661675,26 1433449,66 1311224,51 2409547,15 2506904,02 1039643,23 2879850,31 1170564,07 1338778,34 60S ribosomal protein L10 OS=Mus musculus GN=Rpl10 PE=1 SV=3 Q9D3D9 3 3 254,24 8,39E-01 26152501,74 26606166,13 26471825,51 25417742,16 30787025,25 27450484,82 24691478,68 23053742,03 27445634,59 OS=Mus musculus GN=Bsg PE=1 SV=2 Q4VAA2 3 3 177,45 8,57E-01 50280,49 64005,17 131420,40 96220,25 93051,33 73992,63 62739,51 97483,81 77658,12 Ras-related protein Rab-21 OS=Mus musculus GN=Rab21 PE=1 SV=4 Q9ER35 4 3 190,08 8,61E-01 239452,65 240334,34 209458,44 231914,79 161767,70 232188,17 228003,62 281697,78 144710,66 Purine nucleoside phosphorylase OS=Mus musculus GN=Pnp PE=1 SV=2 P32261 3 3 190,50 8,65E-01 623748,07 326318,84 754878,72 814666,58 694035,13 425546,34 607975,11 476231,46 619723,89 Bisphosphoglycerate mutase OS=Mus musculus GN=Bpgm PE=1 SV=2 P42227 3 3 208,00 8,66E-01 34622,26 34129,76 32437,95 18274,98 34251,32 44952,97 53152,89 30833,40 32714,97 Calumenin OS=Mus musculus GN=Calu PE=1 SV=1 Q9CPU2 3 3 148,40 8,81E-01 2345605,28 1762734,75 1866725,99 1919855,20 1256181,62 3320291,50 2674315,66 2884966,64 1573151,25 Actin-related protein 2/3 complex subunit 5-like protein OS=Mus musculus GN=Arpc5l PE=1 SV=1 Q99KB8 4 3 282,59 8,86E-01 211445,04 187548,46 185814,29 209377,62 188950,92 155818,21 232311,08 135142,75 148612,85 TAR DNA-binding protein 43 OS=Mus musculus GN=Tardbp PE=1 SV=1 O88986 3 3 156,38 9,07E-01 62140,81 38366,74 46747,13 34851,19 41236,23 72997,42 71096,83 16320,54 72505,67 NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Mus musculus GN=Fdxr PE=1 SV=1 P30115 7 3 231,19 9,09E-01 55034,92 54047,39 159618,20 74065,87 71687,22 137063,36 41778,13 81525,83 160676,32 Catenin beta-1 OS=Mus musculus GN=Ctnnb1 PE=1 SV=1 A6H611 3 3 110,06 9,16E-01 36889,51 46199,08 39242,12 31118,04 50034,35 34377,53 43226,62 50468,73 32779,86 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Mus musculus GN=Ndufv2 PE=1 SV=2 Q9CQV1 3 3 222,67 9,18E-01 221074,25 261348,13 251558,92 183520,57 300293,70 269807,95 222545,50 200503,59 285598,07 Cytoplasmic aconitate hydratase OS=Mus musculus GN=Aco1 PE=1 SV=3 O88531 3 3 94,41 9,19E-01 68437,96 150061,06 120968,22 75682,98 174056,58 181097,07 145027,65 66877,78 233631,39 Septin-9 OS=Mus musculus GN=Sept9 PE=1 SV=1 Q8CEI1 3 3 192,31 9,28E-01 479101,94 493766,68 467856,04 457612,44 421446,93 488976,05 470013,11 412402,72 476068,79 Ras-related protein Rab-5A OS=Mus musculus GN=Rab5a PE=1 SV=1 Q76LL6 3 3 134,30 9,30E-01 21979,75 17763,28 37805,60 20234,97 13715,57 34477,86 15631,08 25557,74 19790,51 Protein CEBPZOS OS=Mus musculus GN=Cebpzos PE=3 SV=2 P99024 20 3 1789,97 9,39E-01 624371,65 286180,72 183034,63 261531,80 536490,73 475278,60 768790,26 185825,28 372001,92 Septin-7 OS=Mus musculus GN=Sept7 PE=1 SV=1 P01863 4 3 222,35 9,40E-01 22537,02 183987,52 19863,42 495512,21 18469,56 8233,87 37245,64 10520,47 682882,61 Methionine-R-sulfoxide reductase B2, mitochondrial OS=Mus musculus GN=Msrb2 PE=1 SV=1 P68040 3 3 126,63 9,67E-01 87585,35 86682,81 96777,08 80422,78 58009,78 122409,37 188998,68 120267,06 44945,79 1,4-alpha-glucan-branching enzyme OS=Mus musculus GN=Gbe1 PE=1 SV=1 Q8CC86 3 3 160,01 9,69E-01 69012,02 60478,16 101687,62 94263,25 77197,14 62803,78 39019,84 106218,87 74655,06 Solute carrier family 25 member 46 OS=Mus musculus GN=Slc25a46 PE=1 SV=1 Q9CR61 3 3 215,55 9,72E-01 3665054,84 3618224,82 4638294,07 3685212,10 4166118,78 4181790,60 4884475,07 3993970,54 3457636,67 Cytoglobin OS=Mus musculus GN=Cygb PE=1 SV=1 Q9CWU6 3 2 118,03 6,03E-05 37353,30 48889,61 37650,55 89724,48 135717,67 120967,60 71791,66 79735,82 110860,30 Prenylcysteine oxidase OS=Mus musculus GN=Pcyox1 PE=1 SV=1 Q6PER3 2 2 79,99 5,08E-04 41969,36 40683,00 54707,26 81557,40 78796,57 91047,89 56459,13 70298,62 78839,49 Junctophilin-2 OS=Mus musculus GN=Jph2 PE=1 SV=2 Q921H9 2 2 58,54 9,90E-04 91160,97 108927,54 91136,84 71526,42 71923,98 59101,87 45784,15 45756,35 61666,28 Serine protease inhibitor A3K OS=Mus musculus GN=Serpina3k PE=1 SV=2 P97825 2 2 97,80 1,85E-03 244259,44 196017,77 236407,44 118495,40 103827,42 99703,58 179041,43 237114,72 191128,49 Basal OS=Mus musculus GN=Bcam PE=1 SV=1 O89017 2 2 67,55 4,34E-03 84763,89 110140,13 86436,14 62062,24 96161,81 84899,64 58745,23 42643,64 57362,71 Mitogen-activated protein kinase 1 OS=Mus musculus GN=Mapk1 PE=1 SV=3

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P17047 3 2 97,85 4,47E-03 51958,88 66304,18 47454,11 54437,11 61388,58 61924,16 60779,12 63707,04 68560,76 Perilipin-3 OS=Mus musculus GN=Plin3 PE=1 SV=1 Q6ZWQ0 9 2 221,82 7,18E-03 622188,88 849909,10 808504,86 837694,47 766200,31 683626,26 731142,22 717667,43 990584,09 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Mus musculus GN=Gnb2 PE=1 SV=3 B7ZMP1 2 2 74,84 7,72E-03 27134,24 36401,93 45638,29 70053,25 164084,68 123384,55 28522,02 32954,77 53350,20 Zyxin OS=Mus musculus GN=Zyx PE=1 SV=2 Q8K2I3 2 2 63,12 7,86E-03 34706,22 47068,58 42144,98 95214,62 60667,64 70165,17 74585,05 64207,44 54944,99 Chloride intracellular channel protein 4 OS=Mus musculus GN=Clic4 PE=1 SV=3 Q8BFY9 3 2 94,28 7,98E-03 10048,47 17226,16 13037,54 43637,97 84745,71 36393,99 39813,11 17436,02 55809,48 5'-AMP-activated protein kinase subunit beta-2 OS=Mus musculus GN=Prkab2 PE=1 SV=1 Q9Z2M7 3 2 96,48 1,14E-02 195878,66 198853,57 135121,95 166135,72 135073,03 139129,50 104548,49 79465,72 98773,70 Palladin OS=Mus musculus GN=Palld PE=1 SV=2 Q9CQF0 2 2 92,75 1,17E-02 65015,63 42813,05 56081,76 70731,05 70141,89 95983,12 65476,08 65153,46 74792,68 Peroxisomal NADH pyrophosphatase NUDT12 OS=Mus musculus GN=Nudt12 PE=1 SV=1 O55137 14 2 902,15 1,46E-02 80144,82 40693,36 33039,47 70446,09 62605,01 50373,09 57417,50 252044,64 186776,73 Bleomycin hydrolase OS=Mus musculus GN=Blmh PE=1 SV=1 O55003 2 2 104,17 1,47E-02 21662,01 33011,00 48795,38 120751,79 67334,16 61035,04 51830,99 63758,32 234249,69 Importin-7 OS=Mus musculus GN=Ipo7 PE=1 SV=2 Q8R180 2 2 95,69 1,56E-02 6234,69 6989,52 12057,89 31682,02 18832,36 22670,46 10649,39 6063,48 22745,11 Glutathione S-transferase Mu 1 OS=Mus musculus GN=Gstm1 PE=1 SV=2 Q8JZU0 2 2 81,44 1,64E-02 43020,90 27473,76 30900,98 58155,08 42685,31 54456,45 39936,18 59821,23 99712,33 Ras-related protein Rap-1b OS=Mus musculus GN=Rap1b PE=1 SV=2 P61087 2 2 157,11 1,78E-02 127935,16 112407,58 101096,90 203254,80 195504,73 144893,28 122889,73 111494,64 177386,88 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Mus musculus GN=Plcd1 PE=1 SV=2 Q9CXW3 3 2 78,75 1,82E-02 17071,96 27738,83 22800,66 15554,17 20554,91 16584,87 14339,28 10755,74 16333,34 Striatin-3 OS=Mus musculus GN=Strn3 PE=1 SV=1 Q61699 4 2 127,72 2,29E-02 17349,20 9763,39 5537,49 18317,46 21822,29 45698,50 21018,83 18520,50 34940,83 Proline dehydrogenase 1, mitochondrial OS=Mus musculus GN=Prodh PE=1 SV=2 Q8BYK6;Q91YT7 2 2 61,07 2,30E-02 10672,36 12889,42 16187,97 9006,03 16163,54 11612,76 9122,35 8286,42 7096,76 Hemoglobin subunit beta-1 OS=Mus musculus GN=Hbb-b1 PE=1 SV=2 Q8CAY6 2 2 80,99 2,52E-02 35008,61 33292,84 19807,94 13828,66 14354,45 16605,10 26141,43 17341,44 25235,66 Glutaredoxin-3 OS=Mus musculus GN=Glrx3 PE=1 SV=1 Q60870 2 2 104,48 2,55E-02 2461441,77 1955878,64 2236560,20 1676076,33 2189396,30 1439137,81 1783373,56 1615960,56 1177822,41 Mitochondrial carrier homolog 2 OS=Mus musculus GN=Mtch2 PE=1 SV=1 Q9WUM3 3 2 124,18 3,13E-02 130416,62 135186,63 112535,21 96512,28 96792,33 99700,29 41396,38 68013,75 90050,27 Nucleolar protein 3 OS=Mus musculus GN=Nol3 PE=1 SV=1 Q8R3E3 2 2 61,89 3,41E-02 13236,23 30284,36 18375,46 27372,28 43340,77 38643,24 15814,52 25429,36 27012,54 Mitochondrial glutamate carrier 1 OS=Mus musculus GN=Slc25a22 PE=1 SV=1 P34884 2 2 128,95 3,58E-02 1976847,59 1800148,11 1554175,17 1398980,36 1020392,00 1658949,84 1538513,38 1484146,89 1872616,40 V-type proton ATPase subunit B, brain isoform OS=Mus musculus GN=Atp6v1b2 PE=1 SV=1 P70452 2 2 101,19 3,79E-02 26463,73 22076,95 41394,52 43135,58 34984,49 46770,45 13453,78 27593,93 18596,56 OS=Mus musculus GN=Anxa5 PE=1 SV=1 O54734 2 2 73,04 3,87E-02 55915,22 37581,49 81795,69 106322,98 143467,40 179015,08 82216,55 87084,66 101384,10 Phosphatidylinositol transfer protein beta isoform OS=Mus musculus GN=Pitpnb PE=1 SV=2 Q6PDL0 2 2 117,35 3,99E-02 10931,73 4974,12 9389,11 17874,13 15189,02 12938,92 10270,33 7639,57 10277,44 Developmentally-regulated GTP-binding protein 2 OS=Mus musculus GN=Drg2 PE=1 SV=1 Q8BTE0 2 2 86,24 4,03E-02 42286,79 44212,46 41214,58 61755,90 31052,28 77019,01 41416,19 25874,27 62765,76 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus GN=Cox4i1 PE=1 SV=2 O88441 3 2 194,21 4,18E-02 468118,05 435462,37 1040060,81 981276,06 1248874,07 1173552,16 1089358,79 1125283,46 1263749,65 Integrin alpha-IIb OS=Mus musculus GN=Itga2b PE=1 SV=2 Q8R4S0 2 2 120,81 4,21E-02 284891,89 243486,06 297126,72 115211,23 222773,44 127040,16 166384,73 232760,69 178722,65 Filamin-A OS=Mus musculus GN=Flna PE=1 SV=5 Q61655 2 2 156,90 4,56E-02 38610,25 46032,85 78251,88 95056,67 93482,71 89106,29 50715,57 48004,46 94224,50 DnaJ homolog subfamily C member 28 OS=Mus musculus GN=Dnajc28 PE=1 SV=2 Q9Z0N1;Q9Z0N2 2 2 107,03 4,64E-02 172663,76 81843,30 116451,82 90848,55 65763,78 100071,25 137886,82 87962,15 107474,64 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Mus musculus GN=Plce1 PE=1 SV=3 Q60590 2 2 82,52 4,64E-02 566330,15 475966,48 360633,03 933241,86 1459236,89 1024107,88 859538,32 707906,63 322418,41 Fatty acid-binding protein, epidermal OS=Mus musculus GN=Fabp5 PE=1 SV=3 Q9D5V5 3 2 93,36 4,66E-02 25641,89 37544,80 36546,82 43582,03 45279,94 57936,98 39841,86 50750,76 46037,56 Ankyrin-1 OS=Mus musculus GN=Ank1 PE=1 SV=2 Q91UZ5 2 2 74,66 4,85E-02 41155,74 39463,79 40325,26 60791,88 78346,88 50407,31 52717,40 80903,42 122101,29 RNA-binding protein FUS OS=Mus musculus GN=Fus PE=1 SV=1 Q9Z2X1 4 2 185,92 5,29E-02 159142,67 119025,79 190014,73 204148,95 218513,20 216158,89 169498,01 186934,83 230853,59 Frataxin, mitochondrial OS=Mus musculus GN=Fxn PE=1 SV=1 P62075 2 2 164,81 5,76E-02 1657363,61 1804899,80 1463164,28 1480753,89 1352464,77 1568818,25 1368506,99 1621268,80 1721378,49 E3 ubiquitin-protein ligase RBX1 OS=Mus musculus GN=Rbx1 PE=1 SV=1 Q63810 2 2 64,06 5,80E-02 44067,33 67698,84 54651,59 93498,40 131379,54 106942,52 58589,66 57460,20 90495,31 Ubiquitin-conjugating enzyme E2 N OS=Mus musculus GN=Ube2n PE=1 SV=1 Q9QZF2 2 2 98,34 5,84E-02 86526,49 86027,82 74702,40 71733,84 95119,00 87964,68 42236,60 66168,14 47813,16 dehydrogenase 1 OS=Mus musculus GN=Aldh1a1 PE=1 SV=5 Q8CIZ8 2 2 78,52 5,91E-02 1968,67 1259,29 797,08 3722,16 3183,51 11468,48 3030,72 6430,95 1288,28 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3 P06683 2 2 83,77 6,04E-02 126268,79 15819,70 10075,64 46859,86 29727,72 7075,54 18152,92 3111,10 3297,31 Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Mus musculus GN=Nudt3 PE=1 SV=1 Q8BH97 2 2 99,22 6,19E-02 13975,07 12177,19 11981,86 15251,87 7637,57 16432,80 5191,41 1644,51 7653,48 Protein FAM162A OS=Mus musculus GN=Fam162a PE=1 SV=1 Q9CR84 2 2 67,88 6,24E-02 28297,37 21201,21 1280,39 40481,75 17926,57 63874,92 95424,91 79475,82 48566,09 Golgi resident protein GCP60 OS=Mus musculus GN=Acbd3 PE=1 SV=3 Q61739 2 2 94,14 6,49E-02 25915,09 5145,09 31850,42 44770,28 44612,31 57832,08 27974,82 35758,95 34264,02 Eukaryotic peptide chain subunit 1 OS=Mus musculus GN=Etf1 PE=1 SV=4 Q61584 2 2 72,31 6,56E-02 65014,24 88457,30 81088,97 64050,01 79912,09 56527,98 82152,76 79760,32 86804,01 Alpha/beta hydrolase domain-containing protein 11 OS=Mus musculus GN=Abhd11 PE=1 SV=1 Q65CL1 4 2 116,00 6,58E-02 2097,83 2548,87 3932,56 7054,70 4148,59 15286,99 2424,74 5647,89 6425,70 RB1-inducible coiled-coil protein 1 OS=Mus musculus GN=Rb1cc1 PE=1 SV=3 Q5SSW2 2 2 50,91 6,65E-02 14140,65 16885,63 12742,89 23101,66 15202,67 18035,48 9348,34 2427,02 12810,20 Ras-related protein Rab-1B OS=Mus musculus GN=Rab1b PE=1 SV=1 Q9CYR6 3 2 145,09 6,74E-02 84760,34 61150,21 74552,35 132200,51 92456,20 124519,40 50579,35 51932,86 88536,27 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 Q921Z5 2 2 103,01 6,90E-02 44346,78 119480,16 88729,57 231489,60 156167,34 151985,89 109051,32 73036,07 193936,46 TOM1-like protein 2 OS=Mus musculus GN=Tom1l2 PE=1 SV=1 Q9QYA2 3 2 193,48 7,00E-02 185498,67 140843,24 288711,88 309838,96 442000,69 383562,45 381339,79 336420,05 339979,78 OS=Mus musculus GN=Adk PE=1 SV=2 P62748 2 2 51,96 7,12E-02 11646,98 19545,70 12130,82 21556,19 25801,22 21830,27 19691,42 11237,90 31299,41 Insulin-degrading enzyme OS=Mus musculus GN=Ide PE=1 SV=1 P62855 2 2 128,78 7,13E-02 305050,58 224580,12 267129,66 321203,38 329612,76 353580,51 249846,37 246749,89 256823,16 NADH dehydrogenase [ubiquinone] 1 subunit C2 OS=Mus musculus GN=Ndufc2 PE=1 SV=1 Q8BYJ6 2 2 105,71 7,13E-02 9880,87 6952,15 11003,51 6888,18 6766,39 7566,01 12106,14 17191,05 7552,75 Creatine kinase S-type, mitochondrial OS=Mus musculus GN=Ckmt2 PE=1 SV=1 Q8K199 2 2 49,29 7,17E-02 129665,27 149859,69 150533,13 120983,55 184828,01 121075,53 118017,00 126271,07 127952,44 Spectrin beta chain, erythrocytic OS=Mus musculus GN=Sptb PE=1 SV=4 Q91YE3 2 2 101,39 7,21E-02 17120,31 21605,64 18609,18 20385,28 20650,15 29348,03 25656,79 13885,58 22951,34 Probable ATP-dependent RNA helicase DDX5 OS=Mus musculus GN=Ddx5 PE=1 SV=2 Q9D8P4 2 2 75,40 7,36E-02 37024,06 46455,91 44786,43 49392,74 54895,12 54975,34 51652,18 42177,54 45446,03 Trans-Golgi network integral membrane protein 1 OS=Mus musculus GN=Tgoln1 PE=1 SV=1 Q99N96;A2AAE1 3 2 170,57 7,48E-02 57046,21 87177,83 51086,75 43246,83 34634,55 43156,05 79489,07 51090,76 58474,36 Cytochrome c oxidase subunit 7A2, mitochondrial OS=Mus musculus GN=Cox7a2 PE=1 SV=2 P63073 3 2 101,36 7,49E-02 56145,88 66992,85 80327,99 100611,76 87912,51 108555,72 59884,01 92703,78 126197,13 NAD(P)H-hydrate epimerase OS=Mus musculus GN=Apoa1bp PE=1 SV=1 P46460 2 2 61,72 7,55E-02 26942,88 52157,79 31099,16 33315,54 18188,26 26550,93 24666,35 21379,60 29386,07 Carbonic anhydrase 2 OS=Mus musculus GN=Ca2 PE=1 SV=4 P62717 2 2 40,56 7,61E-02 24571,65 13738,94 14113,91 19522,27 21135,75 20196,07 14618,52 9174,16 16374,02 G, mitochondrial OS=Mus musculus GN=Endog PE=1 SV=1 Q8VCA8 2 2 67,65 7,88E-02 64872,61 78804,35 88267,14 85714,36 70891,27 92958,31 73049,40 87894,34 86989,30 Protein phosphatase inhibitor 2 OS=Mus musculus GN=Ppp1r2 PE=1 SV=3 P62267 3 2 139,28 8,05E-02 172154,23 176822,17 172433,24 146186,26 168588,18 160853,39 107987,90 145028,32 115008,25 Transmembrane emp24 domain-containing protein 2 OS=Mus musculus GN=Tmed2 PE=1 SV=1 Q920Q8 2 2 171,64 8,09E-02 28856,44 15265,19 47879,74 41376,59 47299,25 66974,29 27467,38 43327,56 34403,52 N-acetyl-D- OS=Mus musculus GN=Nagk PE=1 SV=3 Q8VDC1 6 2 207,23 8,19E-02 35609,64 56820,29 34075,42 74849,69 92352,77 104035,71 72437,02 49670,70 174135,25 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 Q9QZD9 3 2 142,39 8,36E-02 77128,34 72358,78 73104,28 33191,73 45395,11 73857,33 85661,25 69489,55 52759,00 Eukaryotic translation initiation factor 3 subunit E OS=Mus musculus GN=Eif3e PE=1 SV=1 Q8CBE3 2 2 46,66 8,39E-02 53587849,83 49442143,88 40377568,98 27723823,25 33091867,58 28040888,04 32230088,96 15056182,90 45190213,30 Glutamate dehydrogenase 1, mitochondrial OS=Mus musculus GN=Glud1 PE=1 SV=1 P08556;P32883 2 2 115,78 8,44E-02 116127,89 63635,84 108765,31 140624,62 186211,99 186611,38 141055,50 137051,58 122462,44 Protein LSM12 homolog OS=Mus musculus GN=Lsm12 PE=1 SV=1 P01644;P01643;P016462 2 183,60 8,45E-02 2177129,96 1342091,78 99578,20 207058,12 64531,44 182576,05 361130,69 692322,59 379563,61 Adenosylhomocysteinase OS=Mus musculus GN=Ahcy PE=1 SV=3 O35972 2 2 122,85 8,56E-02 76930,16 72041,87 69812,28 115340,85 118915,10 91091,59 76457,37 95452,15 110829,42 Heterogeneous nuclear ribonucleoprotein U OS=Mus musculus GN=Hnrnpu PE=1 SV=1 Q8VCR7 2 2 95,80 8,59E-02 47851,15 41521,16 57681,66 51368,46 36313,48 55189,49 41620,06 43540,89 71270,38 Coatomer subunit beta OS=Mus musculus GN=Copb1 PE=1 SV=1 Q924T2 2 2 123,92 8,89E-02 46436,40 54828,42 60905,15 56016,50 62496,64 43457,13 28266,45 26993,58 54959,42 GTP:AMP AK3, mitochondrial OS=Mus musculus GN=Ak3 PE=1 SV=3 Q9D1N9 3 2 105,77 9,24E-02 64932,07 72013,44 88111,33 51898,28 79727,63 75668,97 31886,61 48033,75 45675,41 Elongation factor 1-alpha 2 OS=Mus musculus GN=Eef1a2 PE=1 SV=1 Q6ZPJ3 2 2 75,94 9,77E-02 15080,14 3121,05 10776,68 8092,27 18700,15 19550,49 7920,26 8176,61 11698,96 Ragulator complex protein LAMTOR1 OS=Mus musculus GN=Lamtor1 PE=1 SV=1 Q9Z2N8 2 2 76,62 9,90E-02 42182,35 46030,75 40910,23 67283,54 71067,77 76681,11 38343,28 45553,57 66290,99 WD repeat-containing protein 90 OS=Mus musculus GN=Wdr90 PE=1 SV=2 Q9Z1Q9 3 2 118,50 1,01E-01 54630,04 28925,15 72768,46 68914,19 65509,51 62553,07 83483,33 64027,87 68639,55 Drebrin-like protein OS=Mus musculus GN=Dbnl PE=1 SV=2 P68181 7 2 298,47 1,04E-01 34427,43 42666,20 64745,26 77222,27 80414,65 74230,83 73995,11 39262,96 65889,08 Eukaryotic translation initiation factor 3 subunit B OS=Mus musculus GN=Eif3b PE=1 SV=1 Q9Z1D1 3 2 85,18 1,05E-01 144352,18 172343,89 122321,98 102617,21 132066,04 127348,76 147479,45 106329,68 107768,15 Nucleophosmin OS=Mus musculus GN=Npm1 PE=1 SV=1 P48024;Q9CXU9 2 2 158,21 1,05E-01 393041,32 597880,36 502540,10 491079,07 446053,83 399356,45 563727,66 290596,24 315423,02 BTB/POZ domain-containing protein KCTD12 OS=Mus musculus GN=Kctd12 PE=1 SV=1 Q60692 3 2 160,99 1,05E-01 323488,28 296891,79 454365,45 542605,73 582483,14 398399,58 416205,83 606477,77 578901,20 [Protein ADP-ribosylarginine] hydrolase OS=Mus musculus GN=Adprh PE=1 SV=1 P47811 3 2 125,25 1,06E-01 55361,29 47102,53 44432,56 130537,63 30880,48 90746,81 104890,73 77649,60 131006,01 T-complex protein 1 subunit theta OS=Mus musculus GN=Cct8 PE=1 SV=3 P50543 2 2 102,74 1,06E-01 85872,66 60700,66 230119,77 372521,36 224306,26 298589,97 99960,45 230728,78 354560,60 Coiled-coil domain-containing protein 47 OS=Mus musculus GN=Ccdc47 PE=1 SV=2 Q91WK1 2 2 58,07 1,06E-01 125015,50 141870,45 117912,23 191766,77 164138,46 160176,47 125902,58 140020,04 152963,10 26S proteasome non-ATPase regulatory subunit 5 OS=Mus musculus GN=Psmd5 PE=1 SV=4 Q9CXW2 2 2 60,40 1,12E-01 27530,37 24466,56 31799,40 14252,87 18635,21 16800,68 18625,48 30796,80 13298,15 Ubiquitin-like modifier-activating enzyme 5 OS=Mus musculus GN=Uba5 PE=1 SV=2 Q60605;Q8CI43 4 2 173,03 1,13E-01 308310,05 232520,21 226587,13 336243,70 294482,67 254825,91 386448,96 211531,95 249690,67 Atlastin-3 OS=Mus musculus GN=Atl3 PE=1 SV=1 P97493 2 2 49,67 1,18E-01 1983644,43 1961380,72 1889327,81 1239984,47 1249158,95 1272578,53 2618416,70 1851166,01 1104923,22 Protein transport protein Sec23A OS=Mus musculus GN=Sec23a PE=1 SV=2 P35762 2 2 151,28 1,19E-01 602649,75 580241,29 435522,46 609224,77 676865,20 704397,92 393530,71 539310,98 542397,01 Ig heavy chain V region 102 OS=Mus musculus PE=1 SV=1 P31532 2 2 154,10 1,23E-01 159579,80 41412,05 32977,84 123909,95 121780,75 32311,45 54313,33 39774,82 23142,16 28S ribosomal protein S26, mitochondrial OS=Mus musculus GN=Mrps26 PE=1 SV=1 Q9JIK9 3 2 118,12 1,25E-01 26433,07 20421,36 8756,25 29249,11 36125,53 35880,70 21040,93 39504,84 17384,62 Tubulin beta-4B chain OS=Mus musculus GN=Tubb4b PE=1 SV=1 Q64523;Q64522 5 2 319,61 1,26E-01 4892211,97 4607508,31 4176063,91 2562627,42 3242793,60 4105947,69 4232055,55 4885328,06 2239883,27 Oxysterol-binding protein-related protein 1 OS=Mus musculus GN=Osbpl1a PE=1 SV=2 P62827 4 2 238,75 1,31E-01 1776488,45 2123694,65 1489832,54 1511946,13 1480661,04 1409324,27 2101538,86 1183610,92 1791185,91 Microsomal glutathione S-transferase 1 OS=Mus musculus GN=Mgst1 PE=1 SV=3 Q9D773 2 2 97,40 1,32E-01 248982,64 156256,96 203675,33 175447,09 217456,98 155624,89 195463,63 178839,72 141334,03 Eukaryotic translation initiation factor 5B OS=Mus musculus GN=Eif5b PE=1 SV=2 P54729 2 2 42,37 1,32E-01 76614,70 75608,44 53765,41 77049,38 72570,63 97903,07 69895,15 63256,59 98311,27 Ubiquitin carboxyl-terminal hydrolase 15 OS=Mus musculus GN=Usp15 PE=1 SV=1 Q8BIW1 2 2 100,28 1,32E-01 45052,69 54379,96 44936,87 66425,60 85089,82 87929,07 44315,03 71412,13 87431,89 Ribosome-recycling factor, mitochondrial OS=Mus musculus GN=Mrrf PE=1 SV=1 Q8K215 2 2 117,56 1,33E-01 117014,35 104515,03 142230,27 124179,79 148041,70 178311,89 130443,44 174140,14 192712,16 ATP synthase subunit f, mitochondrial OS=Mus musculus GN=Atp5j2 PE=1 SV=3 O35226 3 2 175,30 1,34E-01 37346,34 26945,91 30469,97 43791,67 33363,30 45548,45 45493,51 40564,62 48982,81 Protein unc-45 homolog B OS=Mus musculus GN=Unc45b PE=1 SV=1 Q66JZ4 2 2 53,65 1,36E-01 549305,48 641355,10 758671,53 923856,42 889771,43 759320,56 767214,94 926935,58 692393,57 Heat shock 70 kDa protein 4L OS=Mus musculus GN=Hspa4l PE=1 SV=2 P52760 2 2 113,51 1,38E-01 23243,72 24923,44 37401,88 17617,34 15416,28 60205,14 42154,68 14108,30 34997,83 OTU domain-containing protein 6B OS=Mus musculus GN=Otud6b PE=1 SV=1 Q9QXC1 3 2 164,05 1,40E-01 451580,02 400936,26 360985,15 597719,11 457881,14 427348,92 469255,51 324771,31 473006,71 Cardiac OS=Mus musculus GN=Pln PE=1 SV=1 Q7TSV4 3 2 120,17 1,40E-01 18138,58 14893,01 67729,51 112774,96 32603,26 91045,50 124625,68 44759,80 238153,68 GTP-binding protein SAR1b OS=Mus musculus GN=Sar1b PE=1 SV=1 O55022 3 2 129,63 1,40E-01 82815,93 58013,23 143933,23 179700,65 132059,06 175396,99 110611,44 99153,32 130577,35 Putative 60S ribosomal protein L32' OS=Mus musculus GN=Rpl32-ps PE=5 SV=2 Q6NZC7 2 2 60,29 1,41E-01 24911,99 9310,42 277169,50 241399,33 348198,41 221671,58 108626,91 78033,15 362436,01 10 kDa heat shock protein, mitochondrial OS=Mus musculus GN=Hspe1 PE=1 SV=2 Q9R1P1 3 2 166,51 1,46E-01 273356,58 156160,26 221474,70 279832,07 262219,98 264544,23 284027,54 214444,68 303357,71 aminopeptidase OS=Mus musculus GN=Lap3 PE=1 SV=3 P19221 4 2 124,89 1,46E-01 539659,82 268948,49 214699,35 248051,14 310073,58 223137,35 341017,60 144874,52 152356,03 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 OS=Mus musculus GN=Ndufb6 PE=1 SV=3

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P0C0S6 4 2 177,82 1,50E-01 1093103,66 1069340,62 924932,63 576281,65 693181,31 954712,71 1099628,18 1077724,73 531191,42 40S ribosomal protein SA OS=Mus musculus GN=Rpsa PE=1 SV=4 P53810 3 2 161,58 1,54E-01 81412,77 111740,60 79663,47 123123,46 132953,04 146575,20 73438,38 62270,03 100514,06 Hemoglobin subunit epsilon-Y2 OS=Mus musculus GN=Hbb-y PE=1 SV=2 Q61335 2 2 86,75 1,57E-01 231042,80 141449,27 194823,51 147420,57 144107,08 142747,45 200732,14 184020,85 145444,76 Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3 OS=Mus musculus PE=1 SV=1 P11859 2 2 87,95 1,59E-01 13315,70 13458,15 24123,06 12328,51 22325,96 29848,88 28766,99 9933,59 26094,97 Hepatoma-derived growth factor-related protein 2 OS=Mus musculus GN=Hdgfrp2 PE=1 SV=1 Q9D0J8 2 2 177,00 1,59E-01 137517,31 103071,91 199545,74 119269,87 100427,30 59580,06 161698,96 179598,18 108585,66 CAAX prenyl protease 1 homolog OS=Mus musculus GN=Zmpste24 PE=1 SV=2 Q9JIX8 2 2 49,57 1,60E-01 322167,52 359749,25 80338,99 39895,72 44737,84 38918,13 484678,62 60225,49 28085,15 Apoptosis-associated speck-like protein containing a CARD OS=Mus musculus GN=Pycard PE=1 SV=1 Q91VH6 2 2 114,65 1,62E-01 2143,90 0,00 7412,08 7617,93 11371,32 22457,76 9183,28 8923,73 32350,64 Golgi reassembly-stacking protein 2 OS=Mus musculus GN=Gorasp2 PE=1 SV=3 Q9JI39 2 2 78,81 1,64E-01 13354,13 17508,63 55558,36 61506,69 104711,47 18193,00 45760,09 45991,75 69372,48 SUMO-activating enzyme subunit 1 OS=Mus musculus GN=Sae1 PE=1 SV=1 Q9DCU6 2 2 62,39 1,64E-01 98292,82 147067,02 103029,36 109909,08 87035,08 106881,91 55482,35 72314,11 92578,03 Nuclear receptor subfamily 1 group D member 2 OS=Mus musculus GN=Nr1d2 PE=1 SV=1 Q8R3F5 2 2 154,10 1,65E-01 35879,57 80092,51 26558,32 79428,24 101811,98 77330,03 32386,73 18466,96 29978,89 Sodium/potassium-transporting ATPase subunit alpha-2 OS=Mus musculus GN=Atp1a2 PE=1 SV=1 P99027 2 2 176,58 1,66E-01 748915,95 814281,45 566338,38 479728,23 502312,16 497487,11 861209,75 638274,39 320531,01 Ubiquitin-conjugating enzyme E2 D3 OS=Mus musculus GN=Ube2d3 PE=1 SV=1 Q9D0L4 4 2 233,16 1,67E-01 42611,10 63385,17 33305,59 74117,51 73403,55 92371,41 59766,54 42090,03 52538,84 Cytochrome c oxidase subunit 6C OS=Mus musculus GN=Cox6c PE=1 SV=3 Q8R3Q6 3 2 119,62 1,68E-01 86897,63 116476,44 105919,55 65510,54 104100,99 111756,80 69511,12 84681,81 93918,68 Mitochondrial import inner membrane translocase subunit Tim8 A OS=Mus musculus GN=Timm8a1 PE=1 SV=1 P48772 2 2 108,80 1,69E-01 1592128,10 1748543,97 1229828,98 1314550,14 1593366,87 1704037,95 3637040,32 1994755,24 1587457,11 28S ribosomal protein S28, mitochondrial OS=Mus musculus GN=Mrps28 PE=1 SV=1 Q7TMM9;Q9CWF219 2 1648,39 1,71E-01 34531,59 87112,47 43192,74 63347,03 96121,32 159561,90 150681,85 88983,36 76920,38 Proteasome inhibitor PI31 subunit OS=Mus musculus GN=Psmf1 PE=1 SV=1 Q9WTL7 3 2 134,93 1,72E-01 343882,31 374819,50 342063,53 385625,94 534075,97 443584,98 261665,14 356716,89 443158,53 Serrate RNA effector molecule homolog OS=Mus musculus GN=Srrt PE=1 SV=1 Q9CQE3 2 2 73,50 1,72E-01 49845,43 39911,99 49093,28 38463,11 39918,87 28907,70 14842,61 26594,61 17010,63 28S ribosomal protein S29, mitochondrial OS=Mus musculus GN=Dap3 PE=1 SV=1 P01634 3 2 105,14 1,73E-01 551367,68 449071,16 29155,87 90680,79 37396,40 92333,81 167507,02 139017,70 140603,27 Large neutral amino transporter small subunit 3 OS=Mus musculus GN=Slc43a1 PE=1 SV=1 P18872 3 2 153,59 1,76E-01 31671,22 23887,60 54908,38 31120,13 25689,29 20231,98 48723,75 29306,89 32806,84 H-2 class I histocompatibility antigen, K-D alpha chain OS=Mus musculus GN=H2-K1 PE=1 SV=1 O35465 2 2 128,41 1,83E-01 37761,00 58476,06 58840,73 59528,48 69973,81 64407,47 25829,50 25637,21 58072,93 Eukaryotic translation initiation factor 4 gamma 2 OS=Mus musculus GN=Eif4g2 PE=1 SV=2 Q8BL66 4 2 128,68 1,87E-01 17660,80 24769,92 10949,73 27830,22 21723,24 15419,48 32632,61 12660,33 32782,16 Hypoxanthine-guanine phosphoribosyltransferase OS=Mus musculus GN=Hprt1 PE=1 SV=3 O70194 2 2 76,12 1,87E-01 47211,93 63325,26 48139,44 46315,18 37585,53 52451,04 47625,22 40372,79 34838,98 ADP-ribosylation factor GTPase-activating protein 2 OS=Mus musculus GN=Arfgap2 PE=1 SV=1 Q9Z2C5 2 2 83,55 1,96E-01 64330,62 102997,03 84927,71 62367,65 29875,35 93685,21 52226,82 83687,30 68009,25 Adiponectin OS=Mus musculus GN=Adipoq PE=1 SV=2 P05125 2 2 123,91 1,97E-01 2031350,96 263319,00 1055493,87 475936,51 185969,17 149607,10 8406727,39 3683185,85 844237,39 Ras-related protein Rab-35 OS=Mus musculus GN=Rab35 PE=1 SV=1 P24452 2 2 91,84 2,10E-01 24842,53 11056,64 22564,62 17078,84 29393,31 31643,59 23042,23 39271,59 31855,46 Vacuolar protein sorting-associated protein 37C OS=Mus musculus GN=Vps37c PE=1 SV=1 P01887 2 2 94,58 2,13E-01 1204679,87 750128,44 648548,36 771530,44 658941,98 717668,67 977696,56 517130,07 785744,36 Mitochondrial uncoupling protein 3 OS=Mus musculus GN=Ucp3 PE=1 SV=1 Q9EPC5 3 2 96,00 2,14E-01 40091,08 68935,28 34662,86 50229,62 46140,80 81931,37 44447,03 488833,89 144051,15 Protein dpy-30 homolog OS=Mus musculus GN=Dpy30 PE=1 SV=1 Q9ERE7 3 2 99,39 2,18E-01 38218,40 47632,46 61642,63 59407,89 46998,41 44460,73 48846,32 44062,97 45756,40 Sorbin and SH3 domain-containing protein 1 OS=Mus musculus GN=Sorbs1 PE=1 SV=2 P63254 2 2 84,44 2,21E-01 411085,97 498562,44 629687,06 512021,26 385460,46 417951,26 359317,02 398240,48 379420,73 Alpha-synuclein OS=Mus musculus GN=Snca PE=1 SV=2 Q99JT1 2 2 71,86 2,22E-01 16257,83 5332,49 1208,62 16773,48 12099,57 25578,28 8924,97 6505,53 13018,78 C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus GN=Mthfd1 PE=1 SV=4 Q3UMT1 3 2 112,04 2,23E-01 7536,26 1108,50 8823,82 8476,33 15819,04 4130,33 3918,70 12084,15 12915,96 Choline-phosphate cytidylyltransferase B OS=Mus musculus GN=Pcyt1b PE=1 SV=2 Q9CQI3;Q9ERL7 2 2 135,67 2,25E-01 81393,64 134047,58 77095,51 72617,73 56541,08 73740,97 59304,90 48401,96 89410,82 26S proteasome non-ATPase regulatory subunit 1 OS=Mus musculus GN=Psmd1 PE=1 SV=1 Q9CQY6 2 2 131,09 2,26E-01 124432,73 72396,00 82112,74 137630,20 170936,30 163410,00 107483,91 68315,48 133086,72 Casein kinase II subunit beta OS=Mus musculus GN=Csnk2b PE=1 SV=1 P48428 2 2 86,70 2,28E-01 187144,58 188918,61 167405,87 179734,46 139010,90 186609,21 152985,86 94691,02 158614,24 Reactive modulator 1 OS=Mus musculus GN=Romo1 PE=2 SV=1 O70572 2 2 73,25 2,28E-01 21837,31 16346,27 13724,12 27100,56 27521,92 19386,58 17345,16 18314,78 23346,27 cAMP-dependent protein kinase catalytic subunit alpha OS=Mus musculus GN=Prkaca PE=1 SV=3 Q60749 2 2 51,85 2,32E-01 48090,01 66017,71 83298,72 66458,90 82101,82 106769,28 65414,25 52767,09 75633,72 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Mus musculus GN=Cpox PE=1 SV=2 Q91YS8 5 2 208,18 2,33E-01 108293,66 59504,77 46607,17 60798,55 74217,17 56113,64 33064,05 37241,07 56582,40 ATP-dependent zinc metalloprotease YME1L1 OS=Mus musculus GN=Yme1l1 PE=1 SV=1 Q9CZ28 2 2 82,63 2,34E-01 14914,56 15803,37 17580,01 40599,97 12099,24 25484,67 14047,67 11316,30 23648,62 Transferrin receptor protein 1 OS=Mus musculus GN=Tfrc PE=1 SV=1 Q9D0G0 3 2 116,70 2,35E-01 185681,46 82474,55 246705,19 110886,09 108030,76 134395,86 173544,40 196218,42 142067,53 -1 OS=Mus musculus GN=Acy1 PE=1 SV=1 Q8K2M0 4 2 186,63 2,35E-01 55813,05 51241,35 40184,61 43927,41 45687,85 70230,51 28319,21 35720,43 48288,11 Ribose-5-phosphate isomerase OS=Mus musculus GN=Rpia PE=1 SV=2 Q9D8Y0;Q9D4J1 2 2 73,70 2,36E-01 33061,57 45423,93 75553,69 70328,07 57930,25 66838,08 41162,30 36250,81 96941,65 Glycine--tRNA ligase OS=Mus musculus GN=Gars PE=1 SV=1 P97927 2 2 72,11 2,39E-01 75096,12 46408,37 112619,79 124637,42 133933,08 110697,86 63882,56 83234,95 144317,68 Paxillin OS=Mus musculus GN=Pxn PE=1 SV=1 P97352 2 2 46,84 2,40E-01 108995,87 138547,50 179560,11 129547,65 95648,40 65516,37 155056,55 149017,27 72359,75 Alpha-N-acetylgalactosaminidase OS=Mus musculus GN=Naga PE=1 SV=2 Q8BXV2 2 2 177,27 2,42E-01 556824,85 520289,37 478186,99 490494,10 479950,19 562384,87 477336,42 413127,34 495958,74 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Mus musculus GN=Hsd17b10 PE=1 SV=4 Q8R1H0 2 2 95,95 2,49E-01 105723,34 56270,73 156396,80 48552,33 65787,93 39712,11 57744,53 33322,45 85016,74 Ig gamma-3 chain C region OS=Mus musculus PE=1 SV=2 O88947 2 2 64,09 2,51E-01 69099,19 27811,63 26769,27 29446,81 41202,62 25785,65 34249,61 28608,85 40323,92 Eukaryotic translation initiation factor 3 subunit F OS=Mus musculus GN=Eif3f PE=1 SV=2 Q8BH35 2 2 89,07 2,51E-01 367275,14 113070,61 50198,38 109859,19 168812,55 50598,83 109582,22 35872,45 46209,28 Probable leucine--tRNA ligase, mitochondrial OS=Mus musculus GN=Lars2 PE=1 SV=1 Q9D8S9 2 2 64,97 2,53E-01 109020,24 96378,33 92815,50 99103,94 86833,53 101653,23 70768,81 115842,05 93369,52 Ras-related protein Rab-5C OS=Mus musculus GN=Rab5c PE=1 SV=2 P51163 2 2 154,69 2,55E-01 24839,79 26707,72 11360,57 18796,40 16152,56 16603,63 14450,87 24229,53 35150,57 Mitochondrial import inner membrane translocase subunit TIM50 OS=Mus musculus GN=Timm50 PE=1 SV=1 O35343;O35344 2 2 69,68 2,57E-01 91106,72 93670,15 83991,43 86407,32 78223,15 94279,38 47160,33 82606,67 91433,72 Platelet alpha chain OS=Mus musculus GN=Gp1ba PE=1 SV=2 Q9CQM5 2 2 86,44 2,59E-01 319116,38 496515,76 388941,61 323278,64 388126,65 347105,73 278161,87 300314,47 391824,72 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Mus musculus GN=Hnrnpul2 PE=1 SV=2 P26883 2 2 170,35 2,60E-01 4133352,09 4073952,90 2842915,57 2960221,72 2263686,92 2544748,60 3605644,12 3101035,17 2843470,37 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Mus musculus GN=Aldh5a1 PE=1 SV=1 P14069 2 2 72,24 2,60E-01 550394,81 550711,87 478981,67 562416,67 427897,81 425181,12 449799,62 571496,43 729924,81 ATP-dependent RNA helicase Dhx29 OS=Mus musculus GN=Dhx29 PE=1 SV=1 P56393 2 2 66,61 2,62E-01 124847,26 65442,09 171686,58 57400,24 39556,62 93352,24 253494,44 251074,73 51456,25 Alpha-2-macroglobulin receptor-associated protein OS=Mus musculus GN=Lrpap1 PE=1 SV=1 Q78RX3 3 2 101,98 2,63E-01 59291,77 84608,46 62799,80 58311,27 60222,26 73983,15 45685,65 51064,79 42786,02 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Mus musculus GN=Ndufb8 PE=1 SV=1 Q3UHZ5 3 2 85,04 2,64E-01 99211,21 37267,73 91088,36 79814,31 78431,06 100311,82 94108,83 91050,81 44400,86 Catechol O-methyltransferase domain-containing protein 1 OS=Mus musculus GN=Comtd1 PE=1 SV=1 O89020 2 2 54,34 2,65E-01 207973,79 221811,68 416928,61 192466,02 282318,47 352034,11 176013,83 150036,17 428707,03 Moesin OS=Mus musculus GN=Msn PE=1 SV=3 Q99LD8 3 2 178,71 2,69E-01 81242,57 89764,02 102676,25 142458,97 139580,73 88933,34 55857,18 79642,39 125927,45 Mannose-6-phosphate isomerase OS=Mus musculus GN=Mpi PE=1 SV=1 Q8R5C5 6 2 294,38 2,70E-01 161861,30 145960,30 234545,81 179714,90 203006,74 270722,05 224061,32 282471,91 228534,13 Nicotinamide phosphoribosyltransferase OS=Mus musculus GN=Nampt PE=1 SV=1 P61358 2 2 56,94 2,75E-01 177973,16 167349,92 131170,54 158490,00 191363,93 199058,08 195011,57 170069,58 121470,89 Transmembrane protein 126A OS=Mus musculus GN=Tmem126a PE=1 SV=1 Q08481 2 2 51,07 2,75E-01 16309,29 23716,51 38385,31 29236,25 21599,10 27341,91 17302,17 26595,33 26169,65 Gamma-sarcoglycan OS=Mus musculus GN=Sgcg PE=1 SV=2 Q61879 8 2 216,38 2,76E-01 226096,22 141247,22 240540,83 141109,75 124614,11 161457,45 352494,01 193154,85 148142,65 60S acidic ribosomal protein P1 OS=Mus musculus GN=Rplp1 PE=1 SV=1 P70362 2 2 63,93 2,78E-01 2587,18 24429,31 11435,56 18594,76 15838,04 19470,70 12028,72 3472,03 16750,06 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Mus musculus GN=Pin1 PE=1 SV=1 O35127 2 2 68,88 2,81E-01 21403,11 42939,61 41104,43 42440,46 29955,28 61747,23 20404,51 50203,83 105301,69 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadm PE=1 SV=1 Q8R1F5 2 2 62,50 2,81E-01 925,59 23803,82 29277,90 10192,25 65816,61 63660,04 31342,96 47564,15 97988,91 Eukaryotic translation initiation factor 4H OS=Mus musculus GN=Eif4h PE=1 SV=3 Q61334 2 2 67,75 2,82E-01 50042,25 70510,97 51084,03 60345,80 50884,54 55351,70 39099,99 41720,49 51242,80 Septin-11 OS=Mus musculus GN=Sept11 PE=1 SV=4 Q9D0J4 2 2 61,13 2,84E-01 46204,06 49592,64 29484,18 40843,63 38741,36 35769,85 30912,92 28226,96 42101,96 UBX domain-containing protein 1 OS=Mus musculus GN=Ubxn1 PE=1 SV=1 Q9D924 2 2 53,58 2,84E-01 78719,57 110044,88 71089,65 103698,27 76479,38 168325,22 83986,56 67566,46 122999,21 Epidermal growth factor receptor OS=Mus musculus GN=Egfr PE=1 SV=1 Q9D4H8 3 2 103,45 2,88E-01 4606516,03 4319446,03 6049323,74 4070914,12 3859534,92 3459620,47 6234137,92 8598105,10 3953474,30 Vacuolar protein sorting-associated protein 35 OS=Mus musculus GN=Vps35 PE=1 SV=1 Q9D9V3 2 2 88,52 2,89E-01 37425,97 166381,15 84932,63 147405,59 205021,44 119499,08 169708,64 88465,88 115265,68 Single-stranded DNA-binding protein, mitochondrial OS=Mus musculus GN=Ssbp1 PE=1 SV=1 P54731 2 2 67,94 2,89E-01 43588,33 71596,91 60705,92 71562,42 72888,84 61321,77 80587,38 60200,08 65228,59 Peroxiredoxin-2 OS=Mus musculus GN=Prdx2 PE=1 SV=3 P46412 2 2 48,12 2,90E-01 252169,19 116527,19 104042,06 83099,72 83808,76 103834,95 213318,02 137485,98 125874,18 ATP-binding cassette sub-family A member 8-B OS=Mus musculus GN=Abca8b PE=1 SV=2 Q78HU7 2 2 220,17 2,91E-01 134383,10 178698,84 61350,50 35362,62 42404,32 42395,54 134069,20 63715,91 21880,57 Putative TATDN1 OS=Mus musculus GN=Tatdn1 PE=1 SV=1 O35841 2 2 63,91 2,92E-01 263915,24 309389,82 270833,66 278888,87 307973,79 279366,76 299758,67 272399,92 231282,60 Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1 Q9CQ45 3 2 137,19 2,93E-01 19176,17 36435,57 33179,14 33074,67 26061,45 22274,67 53197,22 22726,83 55312,71 Protein transport protein Sec61 subunit beta OS=Mus musculus GN=Sec61b PE=1 SV=3 E9Q9K5 3 2 86,95 2,93E-01 196279,68 276989,85 314167,43 214988,60 161509,04 235045,54 241324,03 314026,44 149159,79 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Mus musculus GN=Ndufv3 PE=1 SV=1 P70699 2 2 91,89 2,93E-01 23450,33 22029,85 42659,38 18566,07 34856,29 46728,81 29025,08 39390,06 63404,58 TSC22 domain family protein 1 OS=Mus musculus GN=Tsc22d1 PE=1 SV=2 P62274 2 2 97,13 2,96E-01 113824,27 88866,40 104825,24 131764,05 135872,65 99266,09 80283,60 131650,26 81917,79 Histone H1.0 OS=Mus musculus GN=H1f0 PE=2 SV=4 O89112 2 2 49,64 2,97E-01 50502,55 54479,72 50641,41 47029,65 47471,82 26898,96 82215,74 76786,70 58105,26 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Mus musculus GN=Slc25a11 PE=1 SV=3 Q9EQQ9 2 2 85,19 3,01E-01 6318,31 10626,52 13555,25 22765,68 21392,77 28426,76 3905,09 10366,29 28922,50 Poly(ADP-ribose) glycohydrolase ARH3 OS=Mus musculus GN=Adprhl2 PE=1 SV=1 Q61206 2 2 72,47 3,02E-01 250605,85 181820,06 149280,97 154277,93 209977,17 142364,99 210034,77 191908,97 155884,63 Isoleucine--tRNA ligase, mitochondrial OS=Mus musculus GN=Iars2 PE=1 SV=1 Q9D1C8 2 2 62,01 3,02E-01 36551,09 33711,22 44744,40 38838,96 46447,07 54653,54 60343,02 35974,12 61369,10 14-3-3 protein eta OS=Mus musculus GN=Ywhah PE=1 SV=2 Q68FL6 3 2 135,32 3,09E-01 176195,72 136809,01 165803,29 166490,29 176245,54 216660,58 134456,32 103470,01 150454,27 ATPase family AAA domain-containing protein 1 OS=Mus musculus GN=Atad1 PE=1 SV=1 Q9D892 3 2 158,47 3,11E-01 634772,39 609885,76 431816,86 544284,66 593275,25 462529,89 421642,19 338070,08 615858,24 Glutathione S-transferase omega-1 OS=Mus musculus GN=Gsto1 PE=1 SV=2 Q9CR51 2 2 104,75 3,11E-01 83120,36 77514,15 55002,25 49158,64 55000,12 56850,08 73200,90 38360,55 64683,70 26S proteasome non-ATPase regulatory subunit 7 OS=Mus musculus GN=Psmd7 PE=1 SV=2 Q9D787 2 2 25,57 3,12E-01 2684530,27 2975072,80 2188504,11 2804173,78 3195895,54 3498346,60 3315331,49 3312654,89 3476194,62 Acyl-CoA-binding protein OS=Mus musculus GN=Dbi PE=1 SV=2 Q9CQ89 2 2 106,88 3,13E-01 918205,81 963041,23 1207098,52 1081413,68 1576809,61 1343413,43 701943,32 886991,31 1483636,23 , mitochondrial OS=Mus musculus GN=Agk PE=1 SV=1 Q9CR86 2 2 66,49 3,20E-01 145231,37 218113,35 72740,36 83908,87 77910,28 59809,50 137904,40 47718,90 77781,61 26S proteasome non-ATPase regulatory subunit 2 OS=Mus musculus GN=Psmd2 PE=1 SV=1 Q9D1R9 3 2 110,36 3,24E-01 108019,96 97344,40 152304,50 53888,78 101934,47 148258,80 136987,20 168940,16 61941,88 Vasodilator-stimulated phosphoprotein OS=Mus musculus GN=Vasp PE=1 SV=4 Q8BKY8 2 2 54,90 3,25E-01 26668,15 3739,39 24222,08 40859,18 31224,70 26547,46 16501,35 21358,34 26386,59 Mycophenolic acid acyl-glucuronide esterase, mitochondrial OS=Mus musculus GN=Abhd10 PE=1 SV=1 P62331 2 2 82,45 3,25E-01 35412,87 39645,91 45626,60 48464,25 50156,24 48134,50 34771,84 46197,09 49465,36 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=1 SV=1 Q8BHC0 2 2 42,66 3,25E-01 151496,96 115938,43 184173,75 98361,51 73384,84 126727,67 133773,84 207035,84 95911,54 Voltage-dependent anion-selective channel protein 2 OS=Mus musculus GN=Vdac2 PE=1 SV=2 O35682 2 2 134,12 3,27E-01 38857,60 46076,13 83741,95 51355,88 33714,62 69459,60 59639,48 50890,41 43636,97 40S ribosomal protein S19 OS=Mus musculus GN=Rps19 PE=1 SV=3 P62082 2 2 62,81 3,32E-01 198327,81 216706,05 253607,51 260159,30 287429,19 457493,43 217398,38 243937,39 185970,06 Laminin subunit beta-2 OS=Mus musculus GN=Lamb2 PE=1 SV=2 Q9D7J4 2 2 85,92 3,32E-01 592076,60 477750,51 360064,32 388151,52 329258,44 868867,36 458383,67 519689,95 395614,19 -converting enzyme OS=Mus musculus GN=Ace PE=1 SV=3 Q8BYL4 3 2 98,54 3,39E-01 93443,88 72532,26 43231,64 83482,24 56512,49 59944,51 28501,66 23544,41 60179,91 Proteasome subunit alpha type-2 OS=Mus musculus GN=Psma2 PE=1 SV=3 Q9JK92 2 2 73,60 3,39E-01 22627,14 21997,37 35280,91 31200,28 24714,65 31173,71 37708,29 33883,44 21050,46 Charged multivesicular body protein 2a OS=Mus musculus GN=Chmp2a PE=1 SV=1 Q5IRJ6 2 2 148,01 3,39E-01 30974,13 50358,92 43498,60 83307,24 75558,61 52387,88 29614,14 130985,52 69855,88 Mitochondrial carrier homolog 1 OS=Mus musculus GN=Mtch1 PE=1 SV=1 Q99JR6 2 2 69,87 3,43E-01 31979,58 31692,61 92716,09 62271,76 49871,75 40229,14 47364,62 107104,26 81665,56 Cold shock domain-containing protein E1 OS=Mus musculus GN=Csde1 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q9D1J3 2 2 87,53 3,47E-01 56324,40 104052,78 83972,98 90159,09 86621,76 68816,52 73351,56 73839,30 112512,91 Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma OS=Mus musculus GN=Tmpo PE=1 SV=4 Q9CQB5 2 2 75,62 3,48E-01 198005,52 297676,37 206568,38 228325,21 242022,68 273442,93 182268,57 203245,50 224180,28 ADP-ribosylation factor 5 OS=Mus musculus GN=Arf5 PE=1 SV=2 P56379 2 2 61,00 3,49E-01 5390508,93 7062771,65 1146919,76 1660428,92 1905504,29 1809420,75 2514270,22 1542822,81 1618042,48 Hypoxia up-regulated protein 1 OS=Mus musculus GN=Hyou1 PE=1 SV=1 P35282 3 2 106,99 3,50E-01 192259,21 175001,36 187138,71 275883,22 205858,53 274607,76 343337,21 186092,98 213591,65 Protein phosphatase 1F OS=Mus musculus GN=Ppm1f PE=1 SV=1 Q9D898 2 2 101,82 3,52E-01 83640,73 68636,10 89242,12 76735,25 111645,42 58656,01 58020,66 48978,66 103796,38 Calpain small subunit 1 OS=Mus musculus GN=Capns1 PE=1 SV=1 Q61578 3 2 124,71 3,54E-01 57482,48 72100,79 49163,37 53328,07 56001,27 61612,69 50120,77 40828,92 59416,35 Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Mus musculus GN=Hmgcl PE=1 SV=2 Q8BTE5 2 2 63,43 3,56E-01 156892,84 152358,41 59766,56 81734,32 77908,26 88654,86 175192,58 79876,66 99386,00 Lumican OS=Mus musculus GN=Lum PE=1 SV=2 Q9CX80 2 2 89,06 3,57E-01 29203,13 21939,27 41693,91 35909,99 28941,55 46535,44 19296,80 75062,98 39449,09 28S ribosomal protein S18b, mitochondrial OS=Mus musculus GN=Mrps18b PE=1 SV=1 Q6PAM0;Q9R078 2 2 89,86 3,60E-01 41060,73 27194,67 38394,19 52845,94 45176,58 51240,71 30213,63 42822,87 49446,09 CMRF35-like molecule 9 OS=Mus musculus GN=Cd300lg PE=1 SV=1 Q8R016 2 2 138,38 3,62E-01 62294,68 67884,78 32288,45 56972,54 42602,74 63620,14 58367,32 68454,09 46828,70 Chromobox protein homolog 3 OS=Mus musculus GN=Cbx3 PE=1 SV=2 P53811 2 2 61,71 3,67E-01 26726,94 7578,35 28666,93 26978,84 35846,40 35668,18 38699,07 38100,23 22329,92 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Mus musculus GN=Hsdl1 PE=1 SV=1 Q8VCE1 2 2 62,86 3,68E-01 18885,51 28256,22 13123,22 27442,02 26997,49 25393,29 25630,08 19566,27 24600,38 Cytosolic acyl coenzyme A thioester hydrolase OS=Mus musculus GN=Acot7 PE=1 SV=2 P56959 2 2 86,16 3,71E-01 19641,38 37444,55 38686,24 30806,51 20627,63 55982,97 53826,61 75939,51 50241,11 Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Mus musculus GN=Camk2b PE=1 SV=2 Q8BWY3 2 2 82,73 3,74E-01 28134,74 3138,30 27821,94 32199,75 26779,24 31986,86 21835,67 12135,14 19720,45 Synaptopodin OS=Mus musculus GN=Synpo PE=1 SV=2 Q9JHR7 2 2 55,89 3,77E-01 91756,53 148529,03 148114,01 144157,25 164601,22 106875,49 102489,40 108335,48 98622,28 G-rich sequence factor 1 OS=Mus musculus GN=Grsf1 PE=1 SV=2 P48771 2 2 140,34 3,80E-01 365850,99 211974,56 328671,79 254418,95 293012,42 229662,87 384011,59 334728,36 355373,46 Lebercilin-like protein OS=Mus musculus GN=Lca5l PE=2 SV=1 Q8R5H1 3 2 130,44 3,98E-01 42890,49 29713,65 27421,49 74368,44 39760,83 36827,92 47396,17 41408,87 44909,72 Low molecular weight phosphotyrosine protein phosphatase OS=Mus musculus GN=Acp1 PE=1 SV=3 Q9EPB4 2 2 84,75 4,05E-01 161353,87 124055,19 87904,40 81549,74 84020,24 65663,10 105089,04 49667,14 140239,44 , mitochondrial OS=Mus musculus GN=Suox PE=1 SV=2 Q9R1T2 3 2 165,57 4,06E-01 33420,00 50760,62 34917,49 43705,49 55171,28 43207,03 23595,75 47727,79 52009,11 STE20-like serine/threonine-protein kinase OS=Mus musculus GN=Slk PE=1 SV=2 Q9CY16 3 2 108,91 4,08E-01 57577,48 90633,57 46773,86 54685,14 73193,01 52933,99 54973,35 36850,21 51935,77 39S ribosomal protein L16, mitochondrial OS=Mus musculus GN=Mrpl16 PE=1 SV=1 Q9ER88 2 2 53,23 4,10E-01 52109,03 47891,36 24511,83 43378,75 42157,24 47390,97 37963,23 47766,63 42852,00 26S proteasome non-ATPase regulatory subunit 11 OS=Mus musculus GN=Psmd11 PE=1 SV=3 Q60994 2 2 173,82 4,12E-01 326473,45 517291,51 985187,60 777253,80 658555,93 934445,64 582113,99 729802,93 586616,48 Prolargin OS=Mus musculus GN=Prelp PE=1 SV=2 P67871 3 2 104,82 4,18E-01 9188,16 20492,18 19919,36 16477,53 34132,90 35524,80 9699,87 8765,60 18812,55 LIM and senescent cell antigen-like-containing domain protein 1 OS=Mus musculus GN=Lims1 PE=1 SV=3 O88967 2 2 62,70 4,21E-01 44505,73 0,00 39931,38 41546,25 7963,60 103540,38 37935,13 25847,50 54699,26 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 Q99JW2 2 2 58,52 4,23E-01 33060,56 26074,17 3694,76 6869,35 9701,83 9005,45 6499,58 10857,62 9391,38 Apoptosis-inducing factor 1, mitochondrial OS=Mus musculus GN=Aifm1 PE=1 SV=1 Q8VI36 2 2 169,43 4,25E-01 21961,36 34508,84 33873,14 39600,29 33839,85 37830,61 29254,28 36103,54 37408,49 Mannose-binding OS=Mus musculus GN=Mbl2 PE=1 SV=2 Q9DCH4 2 2 148,66 4,26E-01 62460,78 90049,22 92581,31 109835,55 86551,39 76341,36 120184,83 59300,41 137660,85 vessel epicardial substance OS=Mus musculus GN=Bves PE=1 SV=1 P55302 3 2 144,70 4,33E-01 57030,11 45629,63 73033,20 63451,45 74226,36 64773,24 35421,02 40584,18 76260,37 Ribosomal protein S6 kinase alpha-5 OS=Mus musculus GN=Rps6ka5 PE=1 SV=2 Q9D8Y1 2 2 66,57 4,34E-01 127021,61 118526,51 89311,04 104560,08 104640,85 99553,50 98019,96 75774,57 91800,94 28S ribosomal protein S31, mitochondrial OS=Mus musculus GN=Mrps31 PE=1 SV=1 P47955 3 2 142,37 4,35E-01 722948,51 563515,57 919193,05 697790,34 961094,58 1267594,29 943070,84 633534,59 549842,03 Sarcolemmal membrane-associated protein OS=Mus musculus GN=Slmap PE=1 SV=2 Q922Y1 2 2 70,80 4,38E-01 122021,19 104573,53 93761,37 76634,41 155361,77 102474,75 72065,96 62765,31 150716,70 60S ribosomal protein L36a OS=Mus musculus GN=Rpl36a PE=1 SV=2 Q01279 3 2 155,42 4,38E-01 150370,39 7676,84 16481,55 59063,28 44365,37 17838,93 49173,10 8498,06 2088,80 26S proteasome non-ATPase regulatory subunit 9 OS=Mus musculus GN=Psmd9 PE=1 SV=1 Q8BK30 2 2 76,30 4,42E-01 172511,17 166981,18 195422,13 138482,02 192741,47 196871,19 184348,15 146658,63 101412,02 cAMP-dependent protein kinase inhibitor alpha OS=Mus musculus GN=Pkia PE=1 SV=2 P62500 2 2 97,58 4,42E-01 88099,69 117743,10 80977,93 99222,03 96165,57 108579,03 55505,23 80422,75 101233,50 Programmed cell death protein 10 OS=Mus musculus GN=Pdcd10 PE=1 SV=1 P09470 2 2 88,02 4,52E-01 16925,82 27695,71 18589,37 63790,39 36301,28 23168,91 35224,24 25368,64 19539,63 BRISC complex subunit Abro1 OS=Mus musculus GN=Fam175b PE=1 SV=1 Q91W50 2 2 48,59 4,53E-01 159374,29 151643,70 137427,18 145489,81 148660,19 274260,91 184270,13 249340,40 160184,63 Fat storage-inducing transmembrane protein 2 OS=Mus musculus GN=Fitm2 PE=1 SV=1 P84084;P61750 5 2 312,95 4,54E-01 109154,89 145837,68 137848,03 114246,45 161388,66 186355,10 158144,00 148023,75 138583,23 AP-3 complex subunit beta-1 OS=Mus musculus GN=Ap3b1 PE=1 SV=2 Q99N84 2 2 100,87 4,57E-01 39680,10 53984,53 36213,03 31501,65 48558,58 48803,54 24940,14 31465,40 30534,41 Mitogen-activated protein kinase 3 OS=Mus musculus GN=Mapk3 PE=1 SV=5 Q99N93 2 2 70,08 4,62E-01 32427,56 57855,30 50241,65 81231,72 78252,34 70999,27 29342,96 46493,71 88521,16 6-phosphogluconate dehydrogenase, decarboxylating OS=Mus musculus GN=Pgd PE=1 SV=3 Q9JK53 2 2 53,07 4,62E-01 50617,98 56691,91 42013,03 48500,76 43665,09 65064,96 51983,89 18252,83 38406,68 Elongation factor 1-beta OS=Mus musculus GN=Eef1b PE=1 SV=5 Q99JW4 4 2 212,86 4,62E-01 265257,40 219215,68 213041,14 190881,92 277358,49 306858,44 210559,25 244391,06 219874,47 ATP-dependent RNA helicase DDX3X OS=Mus musculus GN=Ddx3x PE=1 SV=3 P41317 2 2 141,65 4,64E-01 24003,02 25024,32 32959,77 34697,79 77701,78 28214,03 112393,60 22277,78 41941,64 Cytochrome c oxidase subunit 7A-related protein, mitochondrial OS=Mus musculus GN=Cox7a2l PE=1 SV=1 Q61733 4 2 119,81 4,68E-01 191445,37 122340,53 141989,48 164535,40 189579,62 213019,31 147365,37 160808,86 139819,83 Galectin-related protein OS=Mus musculus GN=Lgalsl PE=1 SV=1 Q63844 3 2 108,57 4,73E-01 138164,15 119364,42 87330,59 83914,12 99063,71 79453,10 123265,28 73382,07 123423,18 5'(3')-deoxyribonucleotidase, cytosolic type OS=Mus musculus GN=Nt5c PE=1 SV=1 P49443;P36993 3 2 130,63 4,82E-01 212602,33 353177,80 284088,25 282806,37 273515,59 265664,74 333047,50 311380,54 297430,11 Phenylalanine--tRNA ligase alpha subunit OS=Mus musculus GN=Farsa PE=1 SV=1 P62858 2 2 142,51 4,83E-01 197736,83 256666,34 362457,73 257196,27 153305,14 251777,87 304078,02 172384,27 241894,80 kidney isoform, mitochondrial OS=Mus musculus GN=Gls PE=1 SV=1 P83940 2 2 149,90 4,84E-01 580085,30 554600,65 468010,63 433212,40 455674,30 517072,10 531846,95 549804,31 505200,98 Fatty OS=Mus musculus GN=Aldh3a2 PE=1 SV=2 Q99PL6 2 2 100,02 4,89E-01 21581,00 22734,73 14197,14 24592,75 14712,41 30243,74 11438,92 11411,10 14669,79 MAP kinase-activated protein kinase 2 OS=Mus musculus GN=Mapkapk2 PE=1 SV=2 Q8C0L9 2 2 55,50 4,89E-01 220536285,17 1352561,20 178471,56 32230285,98 1417333,00 64100768,36 179121674,96 2886456,19 29660680,06 E3 ubiquitin-protein ligase RNF135 OS=Mus musculus GN=Rnf135 PE=2 SV=1 Q9R0M4 2 2 57,61 4,95E-01 95708,46 62033,62 87317,93 83780,06 123625,85 113662,14 158275,10 66648,19 156424,04 RuvB-like 1 OS=Mus musculus GN=Ruvbl1 PE=1 SV=1 O54879 3 2 113,03 4,98E-01 100158,23 76366,55 151671,78 91440,68 79359,37 110059,80 118894,29 135367,52 135404,31 Gap junction alpha-1 protein OS=Mus musculus GN=Gja1 PE=1 SV=2 Q9CQV7 2 2 56,68 5,13E-01 69940,61 93620,41 46990,05 71968,44 115059,01 58213,17 74245,21 93069,55 91764,14 OS=Mus musculus GN=Canx PE=1 SV=1 P60904 2 2 82,77 5,17E-01 57245,43 84350,69 26848,98 44577,37 71856,89 39192,93 36706,66 52193,29 47473,37 Ras-related protein Rab-18 OS=Mus musculus GN=Rab18 PE=1 SV=2 Q8BU88 2 2 75,09 5,19E-01 57841,11 42334,23 46521,27 60712,90 66750,90 48498,26 66474,58 50273,78 56282,69 MAGUK p55 subfamily member 6 OS=Mus musculus GN=Mpp6 PE=1 SV=1 Q9CR98 3 2 136,39 5,20E-01 416445,80 413556,35 293274,80 423725,92 371287,68 345102,55 405470,76 288243,80 388074,51 Peroxiredoxin-6 OS=Mus musculus GN=Prdx6 PE=1 SV=3 Q62465 3 2 112,61 5,25E-01 58244,78 112397,52 104028,36 99367,91 85149,43 76644,20 103911,23 49707,08 120187,74 homolog YKT6 OS=Mus musculus GN=Ykt6 PE=1 SV=1 P62077 2 2 84,49 5,26E-01 85707,56 122280,46 115676,26 78021,31 92729,92 99090,16 89508,92 84184,54 123646,45 Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Mus musculus GN=Hdhd2 PE=1 SV=2 Q8R1I1 3 2 196,10 5,29E-01 9974029,66 8749419,27 10383947,70 9276853,70 9692262,83 7800850,69 11472157,71 7937253,11 6559569,32 T-complex protein 1 subunit delta OS=Mus musculus GN=Cct4 PE=1 SV=3 Q8BMA6 2 2 142,51 5,32E-01 10841,73 7816,21 7002,22 8165,81 9354,23 9378,75 9788,32 12574,30 8410,11 Leucine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Lars PE=1 SV=2 Q91XE4 2 2 125,80 5,33E-01 80013,49 190331,84 100292,63 147214,97 109188,23 206587,27 39219,31 104204,47 164621,44 Protein phosphatase 1A OS=Mus musculus GN=Ppm1a PE=1 SV=1 Q9Z239 2 2 137,50 5,34E-01 1731750,98 2360611,74 1762710,70 1773353,14 1840156,90 1816038,03 1878529,11 1604574,68 1741818,59 Neural cell adhesion molecule 1 OS=Mus musculus GN=Ncam1 PE=1 SV=3 Q60649 2 2 56,50 5,36E-01 20566,15 27561,77 15497,53 28085,62 26218,92 29818,67 15689,93 14005,02 38154,03 40S ribosomal protein S28 OS=Mus musculus GN=Rps28 PE=1 SV=1 Q9DC71 2 2 66,70 5,36E-01 20758,57 13013,59 29432,87 13840,76 13575,11 21502,53 29696,95 34649,88 13187,22 Carbonic anhydrase 3 OS=Mus musculus GN=Ca3 PE=1 SV=3 Q3U0S6 2 2 114,33 5,38E-01 33645,75 30341,56 38164,59 45220,97 47266,81 47196,37 40208,96 11726,76 52085,58 Tetratricopeptide repeat protein 38 OS=Mus musculus GN=Ttc38 PE=1 SV=2 Q60865 3 2 133,13 5,38E-01 60397,41 74620,71 36917,36 34877,24 43469,24 46832,54 16949,39 54541,71 50966,69 Transcription elongation factor B polypeptide 1 OS=Mus musculus GN=Tceb1 PE=1 SV=1 O35386 2 2 58,78 5,42E-01 44551,80 57396,33 46862,37 67149,02 62251,68 62777,02 30873,11 112860,72 74833,46 Gamma-adducin OS=Mus musculus GN=Add3 PE=1 SV=2 Q9D0Q7 2 2 87,90 5,44E-01 38220,64 67479,94 57251,98 57346,08 91202,34 73316,16 37325,19 58315,10 82260,90 Ferritin light chain 1 OS=Mus musculus GN=Ftl1 PE=1 SV=2 Q99KN9 2 2 55,41 5,47E-01 8575,48 12548,44 21143,23 33360,75 23578,60 25740,94 866,73 14024,81 30693,96 Succinate dehydrogenase assembly factor 2, mitochondrial OS=Mus musculus GN=Sdhaf2 PE=1 SV=1 Q9R0Q6 5 2 176,00 5,53E-01 63803,52 78708,51 51349,75 79958,52 68329,36 83015,72 55830,83 43803,36 70610,76 Cytochrome c oxidase assembly protein COX19 OS=Mus musculus GN=Cox19 PE=3 SV=1 B9EJ86 2 2 51,26 5,53E-01 15115243,84 14096566,48 13536257,78 16114111,45 17266704,50 13077371,42 13490343,27 13509162,85 14179825,97 Carabin OS=Mus musculus GN=Tbc1d10c PE=1 SV=1 Q9EPB5 2 2 87,80 5,60E-01 136726,43 157826,99 155799,45 188311,79 209733,70 105757,61 141501,55 179703,45 164536,77 Eukaryotic initiation factor 4A-I OS=Mus musculus GN=Eif4a1 PE=1 SV=1 P47915 2 2 81,59 5,60E-01 82845,13 118666,98 102839,38 65968,55 92930,59 96016,18 108775,18 85612,15 61150,28 Myosin light chain 3 OS=Mus musculus GN=Myl3 PE=1 SV=4 P17426 5 2 234,48 5,61E-01 34254,54 64332,03 19406,87 39850,86 32991,73 44042,53 60152,28 22041,57 26247,31 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Mus musculus GN=Ndufb4 PE=1 SV=3 Q9CXV1 2 2 98,89 5,63E-01 2649462,43 2795039,80 2541350,47 2400621,94 2989439,87 2605867,42 3033034,48 3402753,60 2312034,71 Ubiquitin carboxyl-terminal hydrolase 5 OS=Mus musculus GN=Usp5 PE=1 SV=1 P49615 3 2 99,68 5,68E-01 48119,49 53309,28 57226,18 65421,45 71979,76 59762,82 19974,58 41321,24 77391,52 Mitochondrial import receptor subunit TOM34 OS=Mus musculus GN=Tomm34 PE=1 SV=1 Q9D1M0 3 2 96,87 5,70E-01 136846,44 131021,70 86535,78 151050,51 125376,13 98845,26 128780,07 73484,56 116373,50 Apolipoprotein E OS=Mus musculus GN=Apoe PE=1 SV=2 Q5XJY5 2 2 61,62 5,72E-01 264498,53 182284,76 242356,48 269287,18 259186,94 259017,36 230165,20 239938,00 273625,64 UBX domain-containing protein 6 OS=Mus musculus GN=Ubxn6 PE=1 SV=1 Q9CXW4 3 2 114,06 5,75E-01 475065,46 502907,87 349016,84 425234,75 421165,32 426837,27 425896,11 404313,76 342868,74 Guanine nucleotide-binding protein G(q) subunit alpha OS=Mus musculus GN=Gnaq PE=1 SV=4 Q8R2Y2 2 2 64,45 5,82E-01 1069890,97 932337,91 1618317,54 790173,47 716802,49 1175757,69 2513133,97 1607340,95 680301,25 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Mus musculus GN=Gpcpd1 PE=1 SV=1 Q9ES97;Q8K0T0 3 2 173,58 5,89E-01 1206758,61 1326068,54 814535,56 899522,49 691655,61 915063,95 1452272,26 1045903,26 610216,26 Serine/arginine-rich splicing factor 2 OS=Mus musculus GN=Srsf2 PE=1 SV=4 Q9JII5 2 2 141,42 5,91E-01 116139,58 114835,08 130144,91 126267,55 173931,89 158202,77 82814,89 106944,52 213893,37 60S ribosomal protein L24 OS=Mus musculus GN=Rpl24 PE=1 SV=2 Q9DBG3 6 2 256,15 6,10E-01 47294,71 104418,67 227567,89 123170,82 191387,35 93683,90 82150,51 71197,75 105484,08 OS=Mus musculus GN=Dag1 PE=1 SV=4 Q9D0B5 2 2 72,29 6,13E-01 92018,13 25152,65 9031,74 8761,58 55784,62 3811,54 27076,69 10502,28 15020,03 Hemoglobin subunit beta-H1 OS=Mus musculus GN=Hbb-bh1 PE=2 SV=3 Q3U7R1 2 2 90,92 6,15E-01 43867,43 34377,28 104431,15 74384,01 47438,61 58679,48 95930,68 87703,44 48264,77 Plastin-3 OS=Mus musculus GN=Pls3 PE=1 SV=3 P54116 4 2 210,05 6,16E-01 354207,10 290908,07 177389,43 174825,72 119874,39 184918,47 365647,90 248675,10 144784,03 OS=Mus musculus GN=Anxa4 PE=1 SV=4 P48193 2 2 82,62 6,23E-01 66045,88 38140,73 37024,94 24212,82 25383,82 37302,86 69364,20 43808,82 33048,12 Uncharacterized protein C6orf203 homolog OS=Mus musculus PE=1 SV=1 Q8C181 2 2 70,25 6,29E-01 85592,83 107136,31 67550,29 78280,04 81498,78 57566,06 76694,12 61808,81 113960,36 26S protease regulatory subunit 10B OS=Mus musculus GN=Psmc6 PE=1 SV=1 Q9CR57 2 2 184,57 6,29E-01 146118,48 207563,46 174173,33 135322,91 195095,65 135998,35 189082,42 165406,97 89921,21 , cytoplasmic OS=Mus musculus GN=Mdh1 PE=1 SV=3 O09172 2 2 82,08 6,37E-01 181857,81 154612,96 30349,33 53319,20 88825,26 57520,23 138769,33 45061,23 70537,72 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 OS=Mus musculus GN=Atp2a3 PE=1 SV=3 O54950 2 2 73,27 6,41E-01 48892,04 47405,17 44683,59 58557,37 42557,41 71340,24 110124,19 65217,67 30571,48 Heat shock protein 75 kDa, mitochondrial OS=Mus musculus GN=Trap1 PE=1 SV=1 Q91V64 3 2 163,01 6,42E-01 477060,90 546727,57 367420,29 426309,71 481941,65 345850,25 419630,49 277728,37 530595,66 Podocalyxin OS=Mus musculus GN=Podxl PE=1 SV=2 Q9D0Y8 2 2 161,49 6,45E-01 44494,47 34045,27 95396,19 97830,10 24024,17 104058,29 0,00 43710,45 82805,88 DnaJ homolog subfamily A member 2 OS=Mus musculus GN=Dnaja2 PE=1 SV=1 Q3UHB1 3 2 77,88 6,47E-01 5967,66 30364,03 45434,20 81731,35 59759,95 29552,08 33241,65 13898,27 56376,51 Phosphoglucomutase-like protein 5 OS=Mus musculus GN=Pgm5 PE=1 SV=2 P56392 2 2 175,20 6,52E-01 7987313,15 5304689,24 6026110,79 4730730,76 6799333,49 3885334,18 13930807,39 10152306,69 3806226,38 OS=Mus musculus GN=Rpl5 PE=1 SV=3 Q9JK48 2 2 87,29 6,52E-01 89973,21 120317,85 103628,36 88026,52 106093,92 121367,37 61119,24 85480,01 107276,04 Voltage-dependent subunit alpha-2/delta-1 OS=Mus musculus GN=Cacna2d1 PE=1 SV=1 Q8BK72 4 2 139,03 6,59E-01 111797,69 116733,30 52625,58 83169,19 56036,40 72570,26 110744,18 85688,49 67429,82 ATP synthase-coupling factor 6, mitochondrial OS=Mus musculus GN=Atp5j PE=1 SV=1 P70333 5 2 296,74 6,68E-01 121993,88 172723,27 185156,75 169236,97 186458,65 174454,79 143611,77 166306,66 178500,77 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=1 SV=2 P22599 20 2 1670,41 6,71E-01 3999727,12 1313316,47 2139294,37 1957611,88 1605962,64 926381,93 3198654,25 1259411,39 1159530,99 High mobility group protein B3 OS=Mus musculus GN=Hmgb3 PE=1 SV=3 Q8VIJ6 4 2 163,43 6,75E-01 80958,25 150091,36 66162,89 83943,76 110118,43 174234,08 99696,80 99851,64 93055,54 39S ribosomal protein L41, mitochondrial OS=Mus musculus GN=Mrpl41 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q9EPK7 3 2 116,48 6,83E-01 11902,28 2419,55 11300,46 16128,88 10066,63 8368,44 10500,79 10110,75 14290,98 Dynactin subunit 4 OS=Mus musculus GN=Dctn4 PE=1 SV=1 Q99P58 2 2 45,08 7,03E-01 16972,44 14103,08 7210,53 12391,99 3501,56 19853,59 14253,94 7025,61 6111,97 Mitochondrial import inner membrane translocase subunit Tim10 B OS=Mus musculus GN=Timm10b PE=1 SV=1 P01878 2 2 57,06 7,05E-01 1353623,75 331194,36 72289,72 277120,32 166793,00 235569,75 293634,85 1423404,04 448895,01 E3 ubiquitin-protein ligase UBR4 OS=Mus musculus GN=Ubr4 PE=1 SV=1 Q8BJW6 2 2 80,59 7,13E-01 3351,00 333,06 21072,64 4828,47 3118,27 18499,98 3781,34 28392,33 6246,05 Apolipoprotein C-III OS=Mus musculus GN=Apoc3 PE=1 SV=2 Q6IFZ6;P04104 2 2 131,03 7,19E-01 146749,22 146328,06 181776,64 226649,99 35453,45 161001,68 242462,45 190324,25 116214,63 Enoyl-CoA delta isomerase 2, mitochondrial OS=Mus musculus GN=Eci2 PE=1 SV=2 O89103 3 2 101,12 7,37E-01 20321,77 26375,79 25518,26 43981,70 16817,51 10923,01 34145,65 38952,78 9315,86 Carnitine O-palmitoyltransferase 1, muscle isoform OS=Mus musculus GN=Cpt1b PE=1 SV=1 Q8R050;Q149F3 3 2 114,37 7,40E-01 66760,28 54344,36 72993,27 72722,16 86263,38 74919,83 51951,00 62062,25 100953,33 78 kDa glucose-regulated protein OS=Mus musculus GN=Hspa5 PE=1 SV=3 P62754 3 2 109,50 7,48E-01 249224,84 287059,05 333120,15 307547,70 370614,36 249447,94 506230,81 396492,10 249785,12 Glutathione reductase, mitochondrial OS=Mus musculus GN=Gsr PE=1 SV=3 Q91VN4 2 2 166,04 7,57E-01 13303,41 26931,26 50847,82 15289,58 26046,38 19729,83 28038,14 32320,32 20587,12 Very low-density lipoprotein receptor OS=Mus musculus GN=Vldlr PE=1 SV=1 P63325 2 2 98,00 7,63E-01 175323,67 125304,57 157328,67 157264,10 174691,81 209348,39 249416,64 161239,93 125467,46 Mitochondrial basic amino acids transporter OS=Mus musculus GN=Slc25a29 PE=1 SV=1 O54890 3 2 124,63 7,65E-01 93120,57 56481,52 12685,26 7848,50 38607,09 131246,32 78714,38 46429,65 5666,38 Isoaspartyl peptidase/L- OS=Mus musculus GN=Asrgl1 PE=1 SV=1 P54823 2 2 64,88 7,70E-01 32753,25 25384,93 31157,94 27375,68 24207,75 53670,36 14833,33 41721,87 42441,07 Integrin beta-1-binding protein 2 OS=Mus musculus GN=Itgb1bp2 PE=1 SV=1 Q9WUP7 2 2 51,44 7,86E-01 8895,49 11681,59 25740,80 21122,64 15516,03 18092,77 21857,72 17325,87 11705,23 Nucleosome assembly protein 1-like 4 OS=Mus musculus GN=Nap1l4 PE=1 SV=1 P26638 2 2 66,64 7,96E-01 183486,91 272602,56 132183,84 113016,42 183111,17 137504,01 119616,67 253043,48 301312,06 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Mus musculus GN=Ndufs7 PE=1 SV=1 Q9EQU5 2 2 128,20 7,98E-01 138294,05 249424,67 233920,79 195631,53 218667,51 265409,11 191202,99 153994,07 278255,71 NAD-dependent protein deacetylase sirtuin-2 OS=Mus musculus GN=Sirt2 PE=1 SV=2 Q04857 2 2 92,73 8,10E-01 153,77 590,12 402,25 948,95 850,58 411,49 431,47 949,46 1843,78 Leucine-rich repeat-containing protein 39 OS=Mus musculus GN=Lrrc39 PE=1 SV=1 Q9D8B3 2 2 91,89 8,12E-01 69522,37 4045,91 114025,61 40728,01 64792,12 74230,77 54601,88 65500,23 38078,30 Alpha-2-HS-glycoprotein OS=Mus musculus GN=Ahsg PE=1 SV=1 Q9D6K5 3 2 156,09 8,19E-01 47330,92 71892,77 58383,24 56156,46 70340,02 68145,50 78414,26 53490,25 59883,59 Eukaryotic translation initiation factor 4 gamma 1 OS=Mus musculus GN=Eif4g1 PE=1 SV=1 P45377 4 2 161,69 8,45E-01 426492,13 53584,66 402849,14 211188,72 170425,62 214437,44 228300,54 305621,09 173604,00 Beta-taxilin OS=Mus musculus GN=Txlnb PE=1 SV=2 Q9JHK5 2 2 63,56 8,50E-01 409568,06 392833,55 534583,09 377453,81 465812,14 561157,01 481902,66 453607,86 371166,19 Phosphatidylinositide phosphatase SAC1 OS=Mus musculus GN=Sacm1l PE=1 SV=1 P97765 2 2 70,09 8,64E-01 150857,16 215787,88 152101,87 150293,37 186044,50 150389,70 91254,21 185543,07 195598,76 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial OS=Mus musculus GN=Mmab PE=1 SV=1 P53994 6 2 381,03 8,76E-01 601597,40 665854,89 604872,37 480920,98 764333,61 513974,17 646021,06 589569,86 623249,23 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Mus musculus GN=Gatc PE=1 SV=1 Q9D1L0 2 2 152,82 8,85E-01 385914,07 797949,70 1191242,67 492968,04 749495,43 734519,10 603012,10 1113722,28 684202,76 Proteasome subunit alpha type-7 OS=Mus musculus GN=Psma7 PE=1 SV=1 Q9WU28 4 2 175,66 8,87E-01 33993,67 45622,33 42231,31 44449,71 52252,68 46491,41 29142,89 21841,29 62233,76 Perilipin-2 OS=Mus musculus GN=Plin2 PE=1 SV=2 Q8C0E2 2 2 79,72 8,97E-01 23410,37 14054,22 15294,37 16985,67 14983,86 15020,43 6673,38 16334,90 21694,99 60S ribosomal protein L31 OS=Mus musculus GN=Rpl31 PE=1 SV=1 P97742 4 2 272,42 9,47E-01 11213,49 22452,69 13963,94 10724,00 13910,00 30653,59 5591,74 14248,94 24821,45 Phosphatidylinositol-glycan-specific OS=Mus musculus GN=Gpld1 PE=1 SV=1 P00329 3 2 109,46 9,52E-01 75215,99 80257,87 67496,00 110872,46 83862,63 57991,41 110502,65 49493,84 68770,10 Proteasome subunit beta type-1 OS=Mus musculus GN=Psmb1 PE=1 SV=1 Q71LX4 10 2 517,79 9,66E-01 31964,12 14811,46 30302,64 21562,91 27284,55 30267,42 31116,53 26879,30 25376,94 Mitochondrial import inner membrane translocase subunit TIM14 OS=Mus musculus GN=Dnajc19 PE=1 SV=3 P19258 2 2 153,48 9,79E-01 113209,17 197264,55 170619,28 148178,24 208317,29 157104,40 126032,19 149781,92 210217,12 SLIT-ROBO Rho GTPase-activating protein 3 OS=Mus musculus GN=Srgap3 PE=1 SV=1 Q19LI2 2 2 51,56 9,84E-01 2625,52 14493,97 40548,06 1932,17 3982,95 147914,59 2823,78 2644,09 7464,85 COP9 signalosome complex subunit 4 OS=Mus musculus GN=Cops4 PE=1 SV=1 Q9D1I6 2 2 169,15 9,87E-01 45223,51 73919,80 57516,32 58457,46 56196,36 54680,18 32438,82 77698,95 57628,96 NAD kinase 2, mitochondrial OS=Mus musculus GN=Nadk2 PE=1 SV=2 Q9JJK2 3 2 157,36 9,92E-01 68500,91 82719,64 45056,26 73396,99 59302,30 70968,24 100986,89 44752,86 61287,61 I and transcript release factor OS=Mus musculus GN=Ptrf PE=1 SV=1 Q64471 1 1 30,74 2,96E-04 73467,78 83627,21 74050,49 47365,08 31877,21 40989,74 82199,12 78172,19 79521,69 D-tyrosyl-tRNA(Tyr) deacylase 1 OS=Mus musculus GN=Dtd1 PE=1 SV=2 Q80UM3 2 1 84,57 7,15E-04 12143,92 8112,19 7300,75 30793,13 20044,67 28312,43 18043,64 22585,45 31291,00 Atypical kinase ADCK3, mitochondrial OS=Mus musculus GN=Adck3 PE=1 SV=2 Q9R257 1 1 39,43 7,29E-04 11138,97 8924,49 16820,34 51711,80 58788,90 70388,93 26359,85 58831,89 99116,23 Palmdelphin OS=Mus musculus GN=Palmd PE=1 SV=1 E9Q414 2 1 55,59 7,74E-04 4573,92 6574,05 3089,17 12143,12 19752,54 9205,60 10546,24 7040,34 6635,28 ATPase inhibitor, mitochondrial OS=Mus musculus GN=Atpif1 PE=1 SV=2 Q9D0R4 1 1 27,95 7,96E-04 375960,36 451456,78 420344,21 653372,43 679423,90 595342,74 662956,02 572724,22 645363,13 DnaJ homolog subfamily C member 5 OS=Mus musculus GN=Dnajc5 PE=1 SV=1 Q64314 1 1 32,20 9,22E-04 164197,31 117016,72 173511,34 120385,85 91196,74 134866,93 34550,83 51998,62 54605,87 39S ribosomal protein L22, mitochondrial OS=Mus musculus GN=Mrpl22 PE=1 SV=1 Q6P9N1 1 1 35,10 1,42E-03 2205,18 8761,26 4447,08 27810,55 29864,06 20073,30 16001,08 29444,62 16796,33 Leukotriene A-4 hydrolase OS=Mus musculus GN=Lta4h PE=1 SV=4 Q4KMM3 1 1 34,19 1,79E-03 9012,28 22154,02 13886,96 38101,71 44809,94 36716,68 16967,75 17624,43 32348,43 Protein FAM136A OS=Mus musculus GN=Fam136a PE=1 SV=1 P62862 1 1 34,43 2,14E-03 419946,99 461503,26 430736,96 374016,89 368424,55 400360,31 381490,62 302190,96 305631,45 Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Mus musculus GN=Uchl1 PE=1 SV=1 P12246 1 1 122,63 2,84E-03 42161,00 24151,68 3334,13 849753,97 178889,89 955302,39 55345,75 61222,02 34480,10 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Mus musculus GN=Coa3 PE=1 SV=1 Q8CIV2 1 1 36,82 2,99E-03 204621,92 132328,18 222899,95 100466,50 119327,02 88603,96 95868,58 85844,92 101489,18 Fat storage-inducing transmembrane protein 1 OS=Mus musculus GN=Fitm1 PE=1 SV=1 Q9D7N9 2 1 101,38 3,61E-03 90602,96 75775,67 61856,68 147745,17 151199,12 141242,15 99908,90 94940,48 90047,89 Cold-inducible RNA-binding protein OS=Mus musculus GN=Cirbp PE=1 SV=1 Q61107 1 1 99,54 3,75E-03 246057,80 133198,09 164124,30 147409,61 160510,74 171997,62 60998,87 88737,10 87405,27 Leucyl-cystinyl aminopeptidase OS=Mus musculus GN=Lnpep PE=1 SV=1 Q64462 1 1 24,58 4,10E-03 2225,99 22030,30 1375,89 45763,88 37681,46 34000,06 58161,37 54786,23 57612,87 Serine hydroxymethyltransferase, cytosolic OS=Mus musculus GN=Shmt1 PE=1 SV=3 Q99L04 1 1 50,44 4,21E-03 58244,18 44976,01 55949,92 98321,43 103632,51 81406,12 66180,84 74333,50 90630,33 Uroporphyrinogen decarboxylase OS=Mus musculus GN=Urod PE=1 SV=2 Q9QXK3 1 1 48,17 5,26E-03 7528,88 5763,23 11610,79 23051,01 27978,79 46103,28 23361,49 19279,40 21643,04 membrane protein VAT-1 homolog OS=Mus musculus GN=Vat1 PE=1 SV=3 Q8BFZ1 1 1 35,36 5,97E-03 0,00 0,00 0,00 1323,45 17256,32 6346,81 0,00 0,00 0,00 Mitochondrial import inner membrane translocase subunit Tim8 B OS=Mus musculus GN=Timm8b PE=1 SV=1 Q9D0W5 1 1 36,92 6,39E-03 81354,50 129709,51 102478,85 131272,09 161685,86 97940,37 105791,69 109636,00 117290,80 SH3 domain-binding glutamic acid-rich protein OS=Mus musculus GN=Sh3bgr PE=1 SV=1 P21300 3 1 112,88 6,98E-03 602003,86 477788,57 524752,52 390217,50 377555,78 378264,10 371326,00 404654,64 377861,36 Ig kappa chain V-II region 17S29.1 OS=Mus musculus PE=1 SV=1 Q3UBX0 1 1 71,07 7,06E-03 725690,06 724405,92 550166,97 554208,42 721528,77 749573,16 368298,80 502106,92 502263,51 Kelch-like protein 40 OS=Mus musculus GN=Klhl40 PE=1 SV=1 P05366 2 1 167,53 7,39E-03 6644,36 1845,97 1671,35 202039,62 241557,68 42295,21 4146,22 14289,74 1180,16 Glutaredoxin-related protein 5, mitochondrial OS=Mus musculus GN=Glrx5 PE=1 SV=2 Q8CG73 1 1 27,87 8,54E-03 785230,44 412991,23 751522,98 741696,95 1164179,31 945041,28 1586952,54 1642290,53 1215318,26 dehydrogenase OS=Mus musculus GN=Sord PE=1 SV=3 O55013 1 1 30,94 8,74E-03 12330,40 7017,14 10068,38 12423,28 9424,22 7533,87 4502,29 6334,09 8212,66 Cytochrome b-c1 complex subunit 9 OS=Mus musculus GN=Uqcr10 PE=1 SV=1 Q8BY87 2 1 104,50 9,56E-03 10563,18 8415,48 9742,07 7257,42 6097,83 5548,19 7837,98 9481,24 6526,46 cAMP-dependent protein kinase inhibitor gamma OS=Mus musculus GN=Pkig PE=1 SV=1 Q9D1N2 1 1 29,51 9,77E-03 38787,23 43884,59 46118,52 48327,55 66606,60 35952,84 37139,30 46576,24 52075,76 OS=Mus musculus GN=Gphn PE=1 SV=2 Q3V1M1 3 1 74,91 1,06E-02 6337567,21 5648689,57 5523934,65 2846286,03 3475801,60 2992163,60 7540352,56 4358548,32 4063490,05 NADP-dependent malic enzyme, mitochondrial OS=Mus musculus GN=Me3 PE=1 SV=2 P05367 2 1 153,62 1,21E-02 36140,21 4604,10 19570,09 286263,92 362233,93 47205,86 6100,01 18573,91 10285,05 Methylthioribose-1-phosphate isomerase OS=Mus musculus GN=Mri1 PE=1 SV=1 Q9DBL9 2 1 47,70 1,27E-02 5700,48 6419,39 8456,05 24237,54 43575,39 16580,13 14196,69 61684,90 40035,52 Signal recognition particle subunit SRP68 OS=Mus musculus GN=Srp68 PE=1 SV=2 Q61831 2 1 80,65 1,27E-02 11659,13 16365,25 14719,37 21835,26 26822,54 22742,16 9080,59 6856,36 17176,14 Fermitin family homolog 3 OS=Mus musculus GN=Fermt3 PE=1 SV=1 Q9D1L9 1 1 29,67 1,29E-02 174984,63 139891,38 205353,38 118680,51 119331,20 96139,04 62390,07 126194,56 90135,11 Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3 Q9WV32 3 1 104,12 1,32E-02 92904,98 114357,88 83040,85 66599,43 69067,55 50989,21 63513,62 35351,72 61698,43 Methionine-R-sulfoxide reductase B3, mitochondrial OS=Mus musculus GN=Msrb3 PE=1 SV=2 A2AJI0 1 1 35,53 1,33E-02 41936,05 39384,43 41879,84 24280,46 39206,93 21401,70 25761,87 22556,79 27599,95 ADP-ribose pyrophosphatase, mitochondrial OS=Mus musculus GN=Nudt9 PE=1 SV=1 Q8R4F1 1 1 24,25 1,37E-02 284388,82 258881,52 334000,06 153869,74 145590,45 106118,12 167560,56 113014,10 242099,99 ADP-ribosylation factor 1 OS=Mus musculus GN=Arf1 PE=1 SV=2 Q69ZR2 2 1 52,16 1,40E-02 9308,18 8900,76 12497,45 8359,21 7336,41 9659,16 10523,70 11501,95 10723,37 N-acyl-aromatic-L- (carboxylate-forming) OS=Mus musculus GN=Acy3 PE=1 SV=1 Q91XD2 2 1 81,71 1,44E-02 14591,44 15404,27 11280,09 13483,90 10999,37 10798,71 18157,49 12174,39 7645,64 Ubiquitin-like protein ISG15 OS=Mus musculus GN=Isg15 PE=1 SV=4 P42925 1 1 27,42 1,51E-02 8833,37 14189,04 20333,45 31573,43 31021,90 39463,72 33146,02 43846,85 47710,00 Phospholemman OS=Mus musculus GN=Fxyd1 PE=1 SV=1 P61804 1 1 59,76 1,69E-02 39125,92 23488,04 25741,92 46345,49 40454,55 27966,07 52276,05 36961,07 39646,56 F-actin-capping protein subunit beta OS=Mus musculus GN=Capzb PE=1 SV=3 Q99PG2 3 1 77,87 1,69E-02 104347,29 76497,27 48811,43 93986,39 85848,32 86980,95 134565,53 207093,22 119431,57 Cytochrome c oxidase subunit 5B, mitochondrial OS=Mus musculus GN=Cox5b PE=1 SV=1 Q9QXT0 1 1 79,91 1,75E-02 80237,76 96987,35 57719,13 80178,33 118037,94 121619,27 68606,41 64518,01 39215,46 UPF0562 protein C7orf55 homolog OS=Mus musculus PE=1 SV=1 Q9CYH2 1 1 58,50 1,82E-02 222494,71 466316,02 204454,03 152387,12 154620,93 122585,38 117687,11 84105,39 103865,74 NHL repeat-containing protein 2 OS=Mus musculus GN=Nhlrc2 PE=1 SV=1 Q9Z1D9 1 1 40,24 1,85E-02 981810,13 1353293,96 876737,39 1176116,73 1029594,20 1068818,70 983596,52 974323,28 1240694,45 Caseinolytic peptidase B protein homolog OS=Mus musculus GN=Clpb PE=1 SV=1 Q9R1Q7 1 1 61,73 1,90E-02 273628,76 203064,40 347937,51 333520,20 420865,47 356162,94 430549,60 461203,82 403677,81 Rho GDP-dissociation inhibitor 1 OS=Mus musculus GN=Arhgdia PE=1 SV=3 Q8VBZ3 1 1 76,69 1,92E-02 9708,75 6088,55 5857,67 10772,84 9644,29 11432,98 6820,22 5555,00 7648,68 28S ribosomal protein S15, mitochondrial OS=Mus musculus GN=Mrps15 PE=1 SV=2 B1AQJ2 1 1 24,62 1,94E-02 781101,72 763404,56 701155,12 935913,92 1013514,58 968756,85 767496,15 962028,86 1188995,47 Phosphatidylinositol-binding clathrin assembly protein OS=Mus musculus GN=Picalm PE=1 SV=1 Q99JX4 1 1 35,97 1,97E-02 70775,70 46486,65 43315,83 75673,84 74830,01 72267,21 48263,31 73742,46 101667,85 60S ribosomal protein L19 OS=Mus musculus GN=Rpl19 PE=1 SV=1 Q6PA06 2 1 58,38 2,22E-02 49804,36 60929,64 64195,51 81238,59 110357,89 78906,13 40416,53 31282,16 51303,57 CTP synthase 1 OS=Mus musculus GN=Ctps1 PE=1 SV=2 Q9D1P4 1 1 95,66 2,29E-02 38155,32 42698,52 44279,55 36626,84 28271,12 33229,46 21499,90 24338,37 34285,04 Alpha-1-acid glycoprotein 2 OS=Mus musculus GN=Orm2 PE=1 SV=1 P63323 1 1 33,92 2,36E-02 192768,05 259364,30 207254,16 202377,99 240415,55 209028,88 160655,76 164839,37 195876,32 Ras-interacting protein 1 OS=Mus musculus GN=Rasip1 PE=1 SV=3 Q9CRD2 1 1 31,19 2,44E-02 18916,96 28517,54 25241,26 18898,73 14077,46 22504,79 16609,40 8880,20 12641,04 Ferritin heavy chain OS=Mus musculus GN=Fth1 PE=1 SV=2 Q64685 1 1 29,49 2,44E-02 55247,33 143570,70 226896,51 334565,46 332401,61 423125,37 268729,94 250865,32 215292,64 Caprin-1 OS=Mus musculus GN=Caprin1 PE=1 SV=2 Q8VC74 1 1 43,05 2,47E-02 6497,70 10172,63 2718,48 22441,99 1423,59 11985,44 3311,81 6795,15 7927,83 Ras-related protein R-Ras2 OS=Mus musculus GN=Rras2 PE=1 SV=1 Q9DA03 1 1 39,59 2,56E-02 145842,39 218066,48 198379,98 120659,92 143175,31 112433,38 205684,72 166434,56 141258,21 Xaa-Pro dipeptidase OS=Mus musculus GN=Pepd PE=1 SV=3 P01796 1 1 81,91 2,64E-02 1635016,09 859846,48 162154,96 223291,02 103896,82 60323,12 646859,02 259287,28 246911,85 39S ribosomal protein L32, mitochondrial OS=Mus musculus GN=Mrpl32 PE=1 SV=1 P62137 8 1 349,90 2,68E-02 48041,89 67722,62 61740,91 76603,16 70771,06 83940,75 75001,91 72758,32 70149,28 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Mus musculus GN=Ndufa2 PE=1 SV=3 Q9Z0E6 1 1 47,74 2,74E-02 30634,26 44119,11 23046,80 63912,59 54980,29 73901,51 19636,31 10186,51 47961,28 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Mus musculus GN=Sgta PE=1 SV=2 P09925 1 1 64,29 2,78E-02 227013,73 200358,30 196902,88 196864,04 326919,23 176333,61 121756,55 178213,02 172155,27 NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Mus musculus GN=Sirt5 PE=1 SV=1 P70261 2 1 100,23 2,96E-02 7596,72 7110,35 6696,18 6131,80 7944,12 4841,53 5968,44 6216,31 3679,12 Cyclin-dependent kinase inhibitor 1B OS=Mus musculus GN=Cdkn1b PE=1 SV=2 Q62432 1 1 25,43 3,23E-02 863889,21 813871,52 650343,47 803050,51 747425,62 658088,79 608614,87 704054,21 869745,09 Microtubule-associated proteins 1A/1B light chain 3A OS=Mus musculus GN=Map1lc3a PE=1 SV=1 Q91WM1 1 1 24,59 3,35E-02 33082,04 42590,41 29804,93 15116,57 16951,26 24928,75 17493,80 24185,13 29809,29 Tumor protein D52 OS=Mus musculus GN=Tpd52 PE=1 SV=2 O70493 3 1 92,96 3,52E-02 82061,48 136468,74 87963,95 108556,99 124592,19 118095,75 93081,40 74224,93 150724,15 Fascin OS=Mus musculus GN=Fscn1 PE=1 SV=4 Q9DCA2 1 1 25,76 3,63E-02 23905,53 47450,51 37333,69 94052,47 131589,53 89766,32 25951,56 38835,06 73880,76 39S ribosomal protein L9, mitochondrial OS=Mus musculus GN=Mrpl9 PE=1 SV=2 Q9D154 1 1 35,55 3,77E-02 27456,65 14719,48 22185,36 14002,16 27403,19 56144,57 12996,49 9411,27 26759,46 Phytanoyl-CoA dioxygenase, peroxisomal OS=Mus musculus GN=Phyh PE=1 SV=1 Q5U4C3 1 1 24,60 3,80E-02 31486,58 22522,24 101053,88 178489,73 251723,79 212953,88 56501,77 83485,38 259142,26 Voltage-dependent anion-selective channel protein 3 OS=Mus musculus GN=Vdac3 PE=1 SV=1 Q61735 2 1 135,08 3,83E-02 34085,59 46602,59 592886,41 620925,87 95293,37 693538,87 936402,57 430709,07 967094,22 Apoptosis regulator BAX OS=Mus musculus GN=Bax PE=1 SV=1 Q9DCF9 1 1 69,79 3,93E-02 21358,45 10951,02 5275,72 10164,17 14508,53 21871,72 20516,98 11040,98 25190,61 Calmodulin OS=Mus musculus GN=Calm1 PE=1 SV=2 Q8BPE4 1 1 52,72 4,14E-02 33456,13 35666,93 23283,27 33817,04 26138,72 22501,00 20723,69 30732,98 19241,96 Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Mus musculus GN=Phyhd1 PE=1 SV=2 O35963 3 1 103,09 4,21E-02 43190,27 43594,81 57562,16 51082,41 53490,24 57303,10 33697,23 49745,20 64020,94 Cytochrome b-c1 complex subunit 10 OS=Mus musculus GN=Uqcr11 PE=3 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q99KU0 1 1 75,63 4,21E-02 124335,77 136736,32 145798,41 341620,10 254160,57 377111,60 197154,95 156833,52 231039,24 39S ribosomal protein L45, mitochondrial OS=Mus musculus GN=Mrpl45 PE=1 SV=1 Q9QYR7;Q6Q2Z6 3 1 193,55 4,34E-02 1967684,19 449710,06 431217,29 519944,10 569687,75 458669,89 564906,11 4046895,34 917889,87 Protein DDI1 homolog 2 OS=Mus musculus GN=Ddi2 PE=1 SV=1 Q69ZP3 1 1 39,12 4,35E-02 236421,61 233356,60 143404,79 118234,42 65202,84 152269,49 81482,20 137781,45 67514,55 60S ribosomal protein L18 OS=Mus musculus GN=Rpl18 PE=1 SV=3 Q8K1L5 1 1 38,60 4,49E-02 59591,22 88122,77 54402,09 33217,95 39538,97 57170,38 63607,60 43525,67 52190,50 Transforming protein RhoA OS=Mus musculus GN=Rhoa PE=1 SV=1 Q9WTM5 1 1 45,29 4,56E-02 0,00 0,00 29662,71 26981,92 15999,24 35626,53 4461,78 27229,31 26542,99 Clathrin interactor 1 OS=Mus musculus GN=Clint1 PE=1 SV=2 O70133 1 1 25,25 4,60E-02 1630134,85 1789068,17 2172309,98 2206480,17 2381073,32 2679956,20 2523255,20 2974281,65 2330684,86 Thimet OS=Mus musculus GN=Thop1 PE=1 SV=1 P68369;P05214 18 1 1235,06 4,64E-02 37783,93 46515,63 87732,18 108733,75 215217,13 275799,28 128077,98 110742,77 260906,88 Tetraspanin-9 OS=Mus musculus GN=Tspan9 PE=1 SV=1 P08032 4 1 108,72 4,64E-02 9663,84 6905,67 15012,73 15908,19 31834,14 20932,61 67392,77 44773,94 13163,48 Cytoplasmic FMR1-interacting protein 1 OS=Mus musculus GN=Cyfip1 PE=1 SV=1 Q9D7N3 2 1 41,89 4,64E-02 29710,91 45960,44 37855,59 84769,57 83027,88 101623,60 32405,91 46267,85 93654,98 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Mus musculus GN=Prkaa2 PE=1 SV=3 Q7TPD2 1 1 21,36 4,66E-02 5402,63 170,91 102,76 7447,55 67,91 17592,42 29716,89 40473,82 26821,08 Spermine synthase OS=Mus musculus GN=Sms PE=1 SV=1 O88653 1 1 23,60 4,78E-02 31117,76 29580,22 46176,97 61788,44 124491,92 111049,06 41504,58 72061,07 113524,30 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 Q9D0R2 3 1 74,65 4,96E-02 12533,88 13824,86 7538,69 18695,72 29453,01 21498,21 8465,64 14570,52 25687,60 Actin-related protein 2/3 complex subunit 1A OS=Mus musculus GN=Arpc1a PE=1 SV=1 Q9EQ80 1 1 33,09 5,10E-02 232629,18 291007,65 173056,77 164911,11 146139,38 152001,00 169270,39 124548,07 169823,53 Guanine nucleotide-binding protein subunit alpha-12 OS=Mus musculus GN=Gna12 PE=1 SV=3 Q3TMP8 2 1 136,62 5,12E-02 10366,48 7113,48 26123,59 42363,76 71956,91 59649,05 43685,45 22736,74 25326,75 Spectrin alpha chain, non-erythrocytic 1 OS=Mus musculus GN=Sptan1 PE=1 SV=4 P61290 2 1 63,88 5,28E-02 39715,61 29777,52 26435,12 12703,48 19879,79 29712,02 40350,09 27353,33 36299,39 Oxysterol-binding protein-related protein 8 OS=Mus musculus GN=Osbpl8 PE=1 SV=1 Q8CFI5 2 1 49,02 5,32E-02 0,00 0,00 0,00 481,99 5843,08 10918,96 0,00 875,69 2535,19 Clusterin OS=Mus musculus GN=Clu PE=1 SV=1 P17665 1 1 37,31 5,49E-02 8392,95 5413,89 7048,32 20225,59 11129,56 32350,54 175971,05 9507,32 36724,69 Heat shock protein beta-2 OS=Mus musculus GN=Hspb2 PE=1 SV=2 Q6GQT1 2 1 76,46 5,50E-02 178447,01 187956,13 136526,19 111513,00 124447,18 115688,43 123478,81 117485,72 158931,52 Cytochrome c oxidase subunit 3 OS=Mus musculus GN=mt-Co3 PE=1 SV=2 Q6W8Q3 1 1 72,22 5,56E-02 245719,71 235378,78 372621,20 291494,05 238699,00 235138,26 249274,86 131947,83 194614,81 40S ribosomal protein S21 OS=Mus musculus GN=Rps21 PE=1 SV=1 Q3TFQ1 1 1 40,37 5,56E-02 8123,93 0,00 0,00 4412,19 4354,31 4625,32 7782,51 1444,17 5077,27 UPF0160 protein MYG1, mitochondrial OS=Mus musculus GN=Myg1 PE=1 SV=1 P58021 2 1 97,78 5,59E-02 14998,21 19374,71 28529,44 21426,31 26174,18 27147,74 33250,06 21661,20 23404,29 Glyoxylate reductase/hydroxypyruvate reductase OS=Mus musculus GN=Grhpr PE=1 SV=1 P63024 3 1 294,37 5,65E-02 249337,34 322414,12 262560,20 308871,53 346301,89 404420,69 298804,43 269110,43 251141,26 Methylmalonyl-CoA epimerase, mitochondrial OS=Mus musculus GN=Mcee PE=1 SV=1 P30999 3 1 81,65 5,66E-02 29742,04 60314,70 24797,23 78171,34 64818,52 90318,97 58146,17 106600,90 84139,35 MICOS complex subunit Mic19 OS=Mus musculus GN=Chchd3 PE=1 SV=1 Q9DAT5 1 1 21,86 5,75E-02 28264,21 12711,52 21474,77 36222,99 41931,95 36519,24 13763,45 20208,94 32340,26 Serine hydrolase-like protein OS=Mus musculus GN=Serhl PE=1 SV=1 Q9CS42 1 1 41,27 5,78E-02 19957,17 37012,40 17413,01 21871,36 16545,82 35003,97 15866,80 13661,00 15855,96 Sulfide:quinone oxidoreductase, mitochondrial OS=Mus musculus GN=Sqrdl PE=1 SV=3 Q9D1D4 1 1 56,87 5,80E-02 100719,40 87159,81 125070,29 158997,63 190815,98 162611,17 118818,04 145256,39 121833,73 ADP-ribosylation factor GTPase-activating protein 1 OS=Mus musculus GN=Arfgap1 PE=1 SV=2 P07758 23 1 2012,16 5,83E-02 441452,29 233870,86 519311,62 566493,39 1364111,03 950693,00 1270415,12 651741,14 857544,65 60S ribosomal protein L29 OS=Mus musculus GN=Rpl29 PE=2 SV=2 P00848 1 1 22,57 5,87E-02 37887,03 317722,28 534218,94 762887,22 939108,86 1120127,86 1389788,98 1616106,78 533837,04 Minor histocompatibility protein HA-1 OS=Mus musculus GN=Hmha1 PE=1 SV=2 Q9D938 2 1 68,94 5,90E-02 93552,39 93501,04 120246,15 138904,19 65793,28 47675,16 92413,64 39535,83 39369,59 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Mus musculus GN=Ndufb10 PE=1 SV=3 Q8K0U4 1 1 55,70 6,01E-02 24175,99 7022,76 1901,96 66111,52 43535,46 18292,60 32804,91 18463,12 81925,16 AP-2 complex subunit alpha-1 OS=Mus musculus GN=Ap2a1 PE=1 SV=1 Q9ET01 11 1 529,71 6,27E-02 29030,62 26881,38 9805,20 12015,10 10105,23 14524,18 16885,87 20847,16 15710,42 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial OS=Mus musculus GN=Sdhd PE=1 SV=2 P61957 2 1 121,25 6,32E-02 138268,27 157668,03 160218,30 111803,12 78072,25 105500,25 155990,14 182078,24 117235,02 Isobutyryl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acad8 PE=1 SV=2 Q3UPL0 1 1 71,36 6,45E-02 26128,69 37859,55 32838,61 55811,02 41977,95 65706,36 38731,18 28982,39 54205,91 Enoyl-CoA hydratase domain-containing protein 2, mitochondrial OS=Mus musculus GN=Echdc2 PE=1 SV=2 Q9D1H9 1 1 40,30 6,45E-02 46895,67 90343,78 194370,08 318641,49 237571,78 252279,95 244961,34 183504,31 212213,07 Mitochondrial import inner membrane translocase subunit Tim9 OS=Mus musculus GN=Timm9 PE=1 SV=1 Q3UHJ0 1 1 84,93 6,64E-02 6490,41 14474,22 6454,64 19603,24 25965,67 14293,58 10172,17 15912,04 18287,69 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus GN=Uqcrc2 PE=1 SV=1 Q2KN98 3 1 76,59 6,72E-02 300845,57 259893,54 341653,47 220922,16 329495,33 364794,98 534480,00 675205,35 286050,10 RNA-binding protein 3 OS=Mus musculus GN=Rbm3 PE=1 SV=1 P28654 1 1 23,79 7,15E-02 526,37 769,30 19491,67 18760,10 27109,81 47111,96 69761,93 20381,39 15366,80 Short coiled-coil protein OS=Mus musculus GN=Scoc PE=1 SV=1 P01639 1 1 81,80 7,17E-02 595252,35 353189,47 26680,76 128319,17 14646,51 7968,57 617534,77 112583,84 119952,60 Cyclin-dependent-like kinase 5 OS=Mus musculus GN=Cdk5 PE=1 SV=1 Q9CXS4 1 1 35,06 7,21E-02 11933,23 55424,72 42033,47 104399,76 61627,69 53825,02 51506,73 49860,12 54763,69 , cardiac muscle OS=Mus musculus GN=Tnni3 PE=1 SV=2 P01783 1 1 66,50 7,35E-02 93886,59 99880,77 25734,98 26619,47 19484,11 62698,26 60210,63 147186,74 30456,66 Protein CCSMST1 OS=Mus musculus GN=Ccsmst1 PE=1 SV=1 Q8R197 2 1 55,25 7,49E-02 68476,60 76004,86 65826,05 77914,02 57314,02 56736,43 71705,17 161269,38 89492,13 39S ribosomal protein L46, mitochondrial OS=Mus musculus GN=Mrpl46 PE=1 SV=1 P61082 1 1 38,04 7,57E-02 21679,32 23660,66 23408,75 16146,88 14438,49 15244,59 10739,35 20742,53 18474,84 OS=Mus musculus GN=Cat PE=1 SV=4 Q91ZU6 3 1 71,23 7,72E-02 0,00 0,00 0,00 4361,91 2060,82 0,00 0,00 0,00 0,00 Oxidoreductase NAD-binding domain-containing protein 1 OS=Mus musculus GN=Oxnad1 PE=1 SV=2 Q811G0 3 1 66,12 7,84E-02 3148171,01 2831947,77 4442617,58 3947556,41 5567492,84 4760803,80 2953709,37 3737969,24 4086253,09 40S ribosomal protein S15a OS=Mus musculus GN=Rps15a PE=1 SV=2 P49312 3 1 199,91 7,97E-02 88977,24 94033,53 104818,96 62529,73 48017,22 64857,19 104717,72 92116,62 47482,85 CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus GN=Cisd3 PE=1 SV=1 Q8VH51 1 1 43,22 8,05E-02 7974,09 6353,79 5820,70 4867,38 12495,81 35136,79 0,00 0,00 11956,28 Probable aminopeptidase NPEPL1 OS=Mus musculus GN=Npepl1 PE=1 SV=1 Q9D9A7 1 1 28,44 8,09E-02 125052,54 176617,25 190662,20 204043,43 223411,43 215247,29 124944,84 110950,25 218691,82 Protein SEC13 homolog OS=Mus musculus GN=Sec13 PE=1 SV=3 P40694 1 1 28,42 8,09E-02 88154,91 120674,42 225090,61 107723,91 71394,40 107486,88 141681,78 215000,16 71322,29 -associated protein 4 OS=Mus musculus GN=Ckap4 PE=1 SV=2 Q8BMF5 2 1 59,99 8,21E-02 410656,87 250766,68 51590,57 91557,97 122087,27 74426,44 153334,15 70249,29 83656,14 Thioredoxin domain-containing protein 12 OS=Mus musculus GN=Txndc12 PE=1 SV=1 Q8BGY7 3 1 179,92 8,28E-02 425227,13 322801,30 441483,32 366107,94 329411,15 427433,60 354384,34 454958,75 230240,33 Transcription elongation factor, mitochondrial OS=Mus musculus GN=Tefm PE=1 SV=1 Q8CCM6 1 1 33,23 8,38E-02 47482,60 98145,87 112803,12 94738,63 146686,04 154366,95 232980,88 228059,42 101266,51 Coatomer subunit delta OS=Mus musculus GN=Arcn1 PE=1 SV=2 Q8R2L5 1 1 28,36 8,45E-02 8348,52 17958,59 26585,44 30328,47 35128,87 47397,35 24197,51 22202,18 41631,60 Eukaryotic translation initiation factor 3 subunit H OS=Mus musculus GN=Eif3h PE=1 SV=1 P17183 7 1 500,72 8,51E-02 573615,85 530727,29 403542,56 458820,07 431128,14 429424,34 278590,40 312859,75 476545,10 Small nuclear ribonucleoprotein Sm D3 OS=Mus musculus GN=Snrpd3 PE=1 SV=1 P23591 1 1 83,89 8,60E-02 10561,34 5040,64 1827,70 20601,89 23993,19 7568,67 11294,38 8104,57 26174,28 , type I cytoskeletal 10 OS=Mus musculus GN=Krt10 PE=1 SV=3 P31938 2 1 153,93 8,99E-02 93484,71 123592,87 141125,00 134924,06 143161,48 169906,30 99595,93 104303,92 159870,98 Myosin regulatory light chain 2, atrial isoform OS=Mus musculus GN=Myl7 PE=1 SV=1 Q9D2M8 7 1 348,99 9,02E-02 353247,46 403803,12 232355,24 236786,79 255613,78 227090,10 211707,43 183726,63 257464,96 60S ribosomal protein L11 OS=Mus musculus GN=Rpl11 PE=1 SV=4 A2APY7 1 1 56,54 9,45E-02 37239,95 51329,25 29608,53 72195,97 67774,91 71586,17 53854,12 40724,24 73421,33 Complement factor H OS=Mus musculus GN=Cfh PE=1 SV=2 Q3TVI8 1 1 74,65 9,64E-02 55262,60 43290,28 44490,80 47168,13 55746,85 20561,36 6837,18 33161,36 11228,06 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Mus musculus GN=Ppp2r5a PE=1 SV=1 P62932 1 1 43,28 9,85E-02 36719,46 33314,73 28982,12 32541,61 31319,38 37300,35 17885,12 17282,08 34981,01 Gamma-aminobutyric acid receptor subunit alpha-5 OS=Mus musculus GN=Gabra5 PE=1 SV=1 P02798 1 1 62,36 1,03E-01 20528,81 5164,94 3749,73 75333,12 20682,78 24828,37 6063,46 5453,52 20460,57 DnaJ homolog subfamily B member 2 OS=Mus musculus GN=Dnajb2 PE=1 SV=2 Q9D0F3 2 1 48,93 1,04E-01 6360,08 7387,91 43827,68 23975,46 16940,00 35003,93 115074,30 91568,77 33029,23 Lipoyl synthase, mitochondrial OS=Mus musculus GN=Lias PE=1 SV=1 Q8VE91 1 1 93,56 1,06E-01 41581,93 59667,83 78657,77 143191,17 121673,78 130564,34 48878,33 92229,39 154502,17 Aspartyl/asparaginyl beta-hydroxylase OS=Mus musculus GN=Asph PE=1 SV=1 Q9CZ04 1 1 76,57 1,07E-01 110110,95 111018,05 73992,38 81994,03 78793,63 79714,18 81410,26 63326,49 78370,91 Platelet factor 4 OS=Mus musculus GN=Pf4 PE=1 SV=1 P60840 1 1 55,83 1,08E-01 23063,66 24061,30 20484,01 19552,11 19082,46 10091,97 5153,65 1220,10 14194,62 Bifunctional polynucleotide phosphatase/kinase OS=Mus musculus GN=Pnkp PE=1 SV=2 P01633 2 1 72,86 1,08E-01 773608,44 444290,19 108344,82 210183,35 206992,27 168436,88 380886,92 152858,33 235062,09 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Mus musculus GN=Bckdhb PE=1 SV=2 P53564 3 1 70,83 1,09E-01 290705,57 200411,14 203283,77 505395,89 517560,88 357001,57 335678,70 248641,02 581938,03 Phenylalanine--tRNA ligase beta subunit OS=Mus musculus GN=Farsb PE=1 SV=2 Q99PV0 2 1 56,60 1,09E-01 3094313,70 3066761,88 4280894,96 4287421,00 5006399,04 4467963,61 4174106,10 3909666,76 4597844,25 39S ribosomal protein L49, mitochondrial OS=Mus musculus GN=Mrpl49 PE=1 SV=1 Q9WTS6 1 1 24,56 1,10E-01 1055084,75 1544721,38 1879242,84 802198,31 943507,83 690791,00 1242116,63 2521269,19 732198,42 26S proteasome non-ATPase regulatory subunit 14 OS=Mus musculus GN=Psmd14 PE=1 SV=2 Q9JMA2 1 1 53,38 1,11E-01 461886,63 480817,48 526830,11 371287,15 534054,59 398089,35 323018,76 427813,01 534630,21 Cell surface glycoprotein MUC18 OS=Mus musculus GN=Mcam PE=1 SV=1 Q5DU56 1 1 33,67 1,12E-01 987394,89 1041945,83 439401,47 441056,90 525906,73 389506,67 421315,48 358164,27 499426,53 Nucleoside diphosphate-linked moiety X motif 19, mitochondrial OS=Mus musculus GN=Nudt19 PE=1 SV=2 P09602 1 1 141,91 1,16E-01 44220,93 69275,99 101245,07 50281,37 43855,15 47107,96 77720,76 111027,51 74787,80 Tetraspanin-7 OS=Mus musculus GN=Tspan7 PE=1 SV=2 Q61035;Q99KK9 2 1 68,97 1,17E-01 99735,71 78967,56 90208,96 82140,58 83420,21 89465,03 84511,63 51333,22 96079,67 Syntaxin-binding protein 3 OS=Mus musculus GN=Stxbp3 PE=1 SV=1 Q3UFY8 1 1 55,25 1,18E-01 0,00 11522,70 29927,07 37689,53 42446,03 20033,83 14970,81 28132,87 14498,60 Microsomal glutathione S-transferase 3 OS=Mus musculus GN=Mgst3 PE=1 SV=1 Q8C7X2 1 1 32,24 1,18E-01 21379,43 12346,19 25252,03 33064,40 35912,47 42347,39 56922,22 20098,00 21005,70 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial OS=Mus musculus GN=Ndufb11 PE=1 SV=2 Q91YQ3 1 1 28,94 1,19E-01 4578,55 7263,87 4937,29 18511,41 15999,31 13559,32 4766,93 8122,46 18517,15 Tubulin beta-1 chain OS=Mus musculus GN=Tubb1 PE=1 SV=1 Q9Z1R2 2 1 125,79 1,19E-01 44585,25 48801,84 136704,71 32914,77 76101,96 43881,58 47347,46 95803,71 34716,51 Diablo homolog, mitochondrial OS=Mus musculus GN=Diablo PE=1 SV=2 Q80U63 1 1 56,71 1,19E-01 0,00 0,00 24469,62 2151,56 0,00 37859,61 20861,11 17582,09 55622,49 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3 P39061 1 1 43,73 1,20E-01 56030,49 33648,78 90694,16 121043,13 99408,35 84403,69 88884,19 14045,09 46589,17 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Mus musculus GN=Pdk2 PE=1 SV=2 Q80X85 1 1 87,92 1,22E-01 43568,66 26667,39 58857,04 63179,68 79291,93 65988,91 44988,80 84593,99 51860,46 Cytoskeleton-associated protein 5 OS=Mus musculus GN=Ckap5 PE=1 SV=1 Q6A025 1 1 31,65 1,24E-01 13994,53 15227,07 27374,82 14417,66 12903,86 21273,32 8341,81 33165,57 8833,70 Reticulon-3 OS=Mus musculus GN=Rtn3 PE=1 SV=2 O88186 1 1 56,46 1,25E-01 3526,39 5309,65 0,00 4003,66 18447,52 25340,19 9537,74 59610,66 4920,20 Ubiquitin-like protein 4A OS=Mus musculus GN=Ubl4a PE=1 SV=1 P62264 1 1 62,90 1,26E-01 173603,80 116956,84 179633,85 186872,58 197067,60 189015,01 146683,24 145906,40 128889,81 14-3-3 protein beta/alpha OS=Mus musculus GN=Ywhab PE=1 SV=3 Q8BFU2;P27661 4 1 282,73 1,26E-01 5094532,62 4798054,85 4348767,78 2668606,56 3376901,46 4275751,87 4407075,00 5087364,02 2332515,12 2,4-dienoyl-CoA reductase, mitochondrial OS=Mus musculus GN=Decr1 PE=1 SV=1 P43274 5 1 298,73 1,26E-01 76278,40 84879,41 84412,66 35714,82 40815,17 81323,36 68860,62 73107,65 40558,63 DAZ-associated protein 1 OS=Mus musculus GN=Dazap1 PE=1 SV=2 Q9CR59 1 1 44,83 1,28E-01 76254,48 81173,97 89169,00 99542,59 83678,90 65639,26 75309,94 52073,36 55926,41 Tumor protein D54 OS=Mus musculus GN=Tpd52l2 PE=1 SV=1 O54901 1 1 24,20 1,28E-01 47069,47 91564,29 75537,68 60592,61 71186,98 64980,67 71251,45 98324,24 46499,24 Ras-related protein Rab-7a OS=Mus musculus GN=Rab7a PE=1 SV=2 Q8JZS0 1 1 22,95 1,30E-01 30495,18 32074,82 66400,15 41225,27 52495,85 50817,46 38102,78 85440,75 32538,08 Ran-specific GTPase-activating protein OS=Mus musculus GN=Ranbp1 PE=1 SV=2 Q8BHD7 1 1 29,24 1,33E-01 22902,09 7240,19 12237,29 23393,57 16067,95 22529,13 18046,77 28236,31 14850,34 Gamma-glutamylcyclotransferase OS=Mus musculus GN=Ggct PE=1 SV=1 Q3U4G3 1 1 47,51 1,35E-01 169855,64 156440,47 191247,58 172035,71 208584,49 153852,65 115098,63 148156,73 159392,76 Brain acid soluble protein 1 OS=Mus musculus GN=Basp1 PE=1 SV=3 P97494 1 1 31,51 1,35E-01 3183,19 0,00 6814,16 2651,01 12721,49 15623,02 4313,98 5478,35 21848,41 Long-chain fatty acid transport protein 1 OS=Mus musculus GN=Slc27a1 PE=1 SV=1 Q925F2 1 1 48,82 1,39E-01 19970,52 16813,50 36411,92 45128,40 31662,15 39762,13 27221,97 75290,52 34994,95 Microtubule-associated protein RP/EB family member 2 OS=Mus musculus GN=Mapre2 PE=1 SV=1 Q9D1E6 2 1 105,78 1,42E-01 47078,66 60476,78 43661,83 103715,06 95205,77 120803,50 20676,80 21136,12 159039,95 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Mus musculus GN=Iscu PE=1 SV=1 P14106 1 1 68,60 1,43E-01 44895,81 10898,52 1963,68 13158,49 1709,61 14828,45 7007,34 25,20 2988,80 Metallothionein-1 OS=Mus musculus GN=Mt1 PE=1 SV=1 P58064 1 1 26,28 1,43E-01 36911,76 39868,71 38390,76 92760,66 153076,48 72748,21 8604,75 21894,98 107499,13 RUN and FYVE domain-containing protein 1 OS=Mus musculus GN=Rufy1 PE=1 SV=1 P10711 1 1 23,48 1,44E-01 5782,65 17137,86 24724,97 9232,91 8957,98 14057,99 29403,80 10441,91 29139,89 3-ketoacyl-CoA thiolase, mitochondrial OS=Mus musculus GN=Acaa2 PE=1 SV=3 Q60710 1 1 68,69 1,46E-01 88987,73 482451,50 460052,31 172431,46 446386,92 173386,61 104163,35 75687,09 76099,11 Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Mus musculus GN=Anp32e PE=1 SV=2 P43023 1 1 62,78 1,46E-01 1541422,06 1012356,54 1163954,23 1123231,94 1425767,36 1289849,60 4966980,21 2997632,28 984288,07 Protein kinase C and casein kinase substrate in protein 2 OS=Mus musculus GN=Pacsin2 PE=1 SV=1 Q8BHG1 3 1 113,27 1,47E-01 37215,55 30831,95 29742,01 21036,13 21843,57 16083,75 11789,14 3914,75 20412,92 Inositol-3-phosphate synthase 1 OS=Mus musculus GN=Isyna1 PE=1 SV=1 P97821 2 1 63,68 1,48E-01 27743,06 28816,78 56440,55 76905,01 71909,81 67883,46 20601,37 62723,41 29545,60 Cadherin-5 OS=Mus musculus GN=Cdh5 PE=1 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P70170 1 1 52,92 1,49E-01 12862,09 26173,19 31588,98 29832,57 35387,64 50734,55 35240,97 51993,03 35725,97 OS=Mus musculus GN=Rps9 PE=1 SV=3 Q64092 2 1 53,65 1,49E-01 22433,19 19589,04 27535,41 20979,89 20781,61 23159,08 45533,90 58691,19 20039,32 Tripeptidyl-peptidase 2 OS=Mus musculus GN=Tpp2 PE=1 SV=3 Q4KML4 1 1 95,49 1,51E-01 278111,68 328451,26 302861,37 360837,00 558913,09 461482,24 325684,34 233087,56 439388,54 60S ribosomal protein L23a OS=Mus musculus GN=Rpl23a PE=1 SV=1 Q8BIF0 1 1 77,03 1,52E-01 15185,28 35599,19 55233,64 43825,59 33475,23 53129,70 9723,25 23548,48 26107,99 -1-phosphate uridylyltransferase OS=Mus musculus GN=Galt PE=1 SV=3 Q9EQ06 1 1 41,02 1,54E-01 11094,39 10849,92 24658,47 9851,36 15119,23 19409,41 36687,61 62052,18 22018,93 CDGSH iron-sulfur domain-containing protein 1 OS=Mus musculus GN=Cisd1 PE=1 SV=1 P56394 1 1 50,44 1,54E-01 0,00 0,00 10562,78 6790,48 13510,87 0,00 45964,47 44206,65 2200,89 Transcriptional activator protein Pur-alpha OS=Mus musculus GN=Pura PE=1 SV=1 Q9D289 1 1 22,42 1,57E-01 1730,10 2003,93 3278,60 1515,91 1366,35 93,82 2842,18 2982,26 1920,47 Tetranectin OS=Mus musculus GN=Clec3b PE=1 SV=2 Q91VC9 1 1 67,12 1,58E-01 105790,08 115196,42 110597,88 80155,20 99030,40 83313,43 108962,19 73715,01 110384,71 Acyl-protein thioesterase 1 OS=Mus musculus GN=Lypla1 PE=1 SV=1 Q91VW3 1 1 75,66 1,59E-01 445870,13 642668,13 313876,38 316079,69 254935,10 355877,11 243238,24 262762,45 202042,54 , cardiac muscle OS=Mus musculus GN=Tnnt2 PE=1 SV=2 G5E829 3 1 149,52 1,60E-01 0,00 5025,63 5863,57 31344,52 16041,66 24859,08 11583,91 18223,75 18692,31 OS=Mus musculus GN=Rps5 PE=1 SV=3 P62774 1 1 98,80 1,61E-01 550289,46 402026,64 384259,98 504075,61 487602,78 425496,19 448257,91 224330,77 315875,74 39S ribosomal protein L40, mitochondrial OS=Mus musculus GN=Mrpl40 PE=1 SV=2 Q4U4S6 6 1 158,73 1,64E-01 13950,89 15708,94 7171,43 13827,37 10307,31 20197,37 11805,24 18320,98 15101,87 MOB kinase activator 1B OS=Mus musculus GN=Mob1b PE=1 SV=3 Q7TNS2 1 1 53,24 1,65E-01 257425,57 289645,04 264341,09 262361,25 216781,33 272737,91 545801,66 375830,02 210045,31 Bridging integrator 2 OS=Mus musculus GN=Bin2 PE=1 SV=1 Q9CY57 2 1 113,05 1,67E-01 28464,75 34368,99 41768,25 57321,50 42491,39 37820,14 41052,36 34421,20 32150,43 Emerin OS=Mus musculus GN=Emd PE=1 SV=1 Q9D0M5;Q810P2 3 1 219,91 1,69E-01 1483445,41 1207520,74 1351820,08 1098112,27 1078894,36 1143318,23 1503802,19 883313,33 976958,33 AP-2 complex subunit beta OS=Mus musculus GN=Ap2b1 PE=1 SV=1 P01786 1 1 64,34 1,70E-01 239685,95 155749,22 13071,35 65387,21 17247,85 2482,09 18961,08 16098,85 13960,16 OS=Mus musculus GN=Spr PE=1 SV=1 Q3TC33 2 1 82,04 1,70E-01 21999,16 33730,66 21031,88 31287,72 28256,99 31700,72 49954,19 32993,55 29346,07 Heterogeneous nuclear ribonucleoprotein A0 OS=Mus musculus GN=Hnrnpa0 PE=1 SV=1 A7RDN6 2 1 98,37 1,73E-01 16512,31 51190,64 18159,90 71839,46 71114,89 61220,63 13309,92 59371,95 23959,53 Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 OS=Mus musculus GN=Tstd3 PE=1 SV=1 Q9CT10 1 1 40,57 1,73E-01 376,90 613,92 780,65 4929,01 845,07 3228,94 5446,46 690,45 4466,05 Flavin reductase (NADPH) OS=Mus musculus GN=Blvrb PE=1 SV=3 Q3UN90 2 1 102,82 1,73E-01 131771,87 109118,46 109046,50 94286,12 129412,05 94980,10 120881,50 108719,39 160102,25 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 OS=Mus musculus GN=Ndufa3 PE=1 SV=1 Q91V76 1 1 52,79 1,74E-01 0,00 30807,49 13494,95 49121,31 53081,50 54125,41 47533,18 50706,57 107243,11 Succinate dehydrogenase assembly factor 1, mitochondrial OS=Mus musculus GN=Sdhaf1 PE=1 SV=1 Q5DU05 3 1 77,62 1,75E-01 2859444,07 5360507,40 159200,20 374365,01 1529109,50 36494,08 10470827,70 190817,18 1041221,99 OS=Mus musculus GN=Rpl9 PE=1 SV=2 P01843 1 1 97,51 1,76E-01 483879,50 188535,94 11924,66 3812,54 5103,01 21280,47 9695,22 327833,03 0,00 Phosphoethanolamine/phosphocholine phosphatase OS=Mus musculus GN=Phospho1 PE=1 SV=1 Q9CQH7 1 1 66,04 1,77E-01 182339,82 157720,99 185759,04 180777,42 175779,50 237124,13 127504,18 170916,93 191856,57 -like protein 1 OS=Mus musculus GN=Sypl1 PE=1 SV=2 Q6P6M7 1 1 33,44 1,79E-01 4028467,32 6757792,83 7580963,24 3950245,25 3501611,30 3686581,33 8104161,25 9111421,95 3957266,15 Adenylosuccinate synthetase isozyme 1 OS=Mus musculus GN=Adssl1 PE=1 SV=2 Q99M01 1 1 32,60 1,80E-01 54804,24 51297,17 71038,92 42455,80 19222,19 25323,01 65850,13 28004,33 27146,68 Extended -1 OS=Mus musculus GN=Esyt1 PE=1 SV=2 P62627 2 1 72,42 1,80E-01 192702,47 135510,90 174905,72 260206,69 216022,65 203540,95 198580,93 245317,32 317441,24 Erythrocyte band 7 integral membrane protein OS=Mus musculus GN=Stom PE=1 SV=3 P84104 1 1 35,50 1,80E-01 120834,83 168925,59 60279,76 47713,90 44567,21 86738,54 88488,50 45748,25 24266,19 Vesicle-associated membrane protein-associated protein B OS=Mus musculus GN=Vapb PE=1 SV=3 Q9Z204 1 1 27,26 1,80E-01 3329,19 2349,94 7182,12 2446,33 1286,41 2630,82 9300,50 8869,75 2935,73 S-adenosylmethionine synthase isoform type-2 OS=Mus musculus GN=Mat2a PE=1 SV=2 Q9CQ21 1 1 69,09 1,81E-01 16842,70 18092,46 28916,51 22711,00 23425,08 29058,72 11189,19 9172,06 19638,62 NEDD8-activating enzyme E1 regulatory subunit OS=Mus musculus GN=Nae1 PE=1 SV=1 Q9Z1Z2 2 1 90,18 1,82E-01 12252,00 62513,74 43759,90 67861,30 52486,07 46755,11 42680,48 63254,34 132285,86 Tax1-binding protein 3 OS=Mus musculus GN=Tax1bp3 PE=1 SV=1 P54310 1 1 26,49 1,85E-01 100605,95 107632,26 89953,50 87944,14 113823,07 97156,05 76217,98 58993,58 85144,15 Filamin-binding LIM protein 1 OS=Mus musculus GN=Fblim1 PE=1 SV=2 P01660;P01656;P016582 1 156,25 1,85E-01 810550,59 1388118,99 426906,60 456994,49 356688,15 436475,55 761174,41 350616,04 406890,53 H-2 class I histocompatibility antigen, D-37 alpha chain OS=Mus musculus GN=H2-T23 PE=1 SV=1 P01674 2 1 66,36 1,86E-01 27997,76 11055,56 19,70 19368,56 6998,78 12762,70 9851,85 3412,01 20913,49 Toll-interacting protein OS=Mus musculus GN=Tollip PE=1 SV=1 Q9ET26 1 1 58,41 1,88E-01 94264,63 138968,68 115055,87 119141,46 130985,53 129462,70 53343,37 65833,63 134102,82 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=1 SV=1 P62281 1 1 43,58 1,89E-01 370363,25 445079,80 432486,07 300833,31 329632,66 388014,04 339736,67 410540,86 289544,78 Quinone oxidoreductase OS=Mus musculus GN=Cryz PE=1 SV=1 Q61233 4 1 188,91 1,90E-01 28757,72 31568,89 20774,99 17575,95 21857,29 22770,18 22163,88 85894,54 22793,06 60S ribosomal protein L13a OS=Mus musculus GN=Rpl13a PE=1 SV=4 Q91XE8 1 1 53,66 1,91E-01 213592,11 166158,49 186003,63 152785,73 213612,96 208837,31 181203,80 185489,13 118337,71 Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Mus musculus GN=Gnai2 PE=1 SV=5 Q9R059 1 1 49,60 1,93E-01 30396,66 42984,14 19062,91 26758,32 13294,60 32856,55 23177,39 25764,86 49626,00 Dynein light chain 1, cytoplasmic OS=Mus musculus GN=Dynll1 PE=1 SV=1 Q3U0V1 1 1 44,91 1,95E-01 28506,22 34193,87 35013,73 17886,51 24323,01 18900,12 14462,06 19908,84 66883,53 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Mus musculus GN=Ppp2r2a PE=1 SV=1 Q6ZWV7 1 1 35,17 1,98E-01 240619,78 255673,61 75992,27 97929,57 129150,43 97437,18 95533,22 82324,92 73022,08 ATP synthase subunit d, mitochondrial OS=Mus musculus GN=Atp5h PE=1 SV=3 Q9D1C3 2 1 66,47 1,98E-01 36085,67 43275,22 37899,70 54051,38 55210,63 59470,21 35543,43 73859,96 52594,07 Transmembrane protein 256 OS=Mus musculus GN=Tmem256 PE=1 SV=1 Q00915 1 1 69,58 2,02E-01 103442,64 65746,44 143637,17 166888,27 78851,18 75487,13 136307,32 69228,37 166489,88 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Mus musculus GN=Hadh PE=1 SV=2 Q9D7X3 1 1 60,29 2,04E-01 415645,94 284999,50 281088,37 303987,47 473416,05 339378,76 264223,07 368927,57 316368,55 Ornithine aminotransferase, mitochondrial OS=Mus musculus GN=Oat PE=1 SV=1 G5E8K5 3 1 113,85 2,04E-01 13170724,84 15685490,78 29177908,63 14679954,08 14464683,79 20507896,11 15528468,30 47308148,29 9823438,36 Alpha-1-syntrophin OS=Mus musculus GN=Snta1 PE=1 SV=1 Q14B71 1 1 37,94 2,05E-01 5415,24 6657,88 5800,76 5309,54 4008,96 5922,79 9093,65 15810,25 4732,80 Protein 4.1 OS=Mus musculus GN=Epb41 PE=1 SV=2 Q499X9 1 1 41,25 2,06E-01 46590,02 46745,11 51412,57 37663,84 14416,37 34967,47 30929,98 30169,05 19203,16 CASP8 and FADD-like apoptosis regulator OS=Mus musculus GN=Cflar PE=2 SV=2 Q3V132 4 1 280,38 2,07E-01 712227,45 768489,98 866119,12 840445,99 968690,75 935412,39 799481,24 913360,91 939905,46 39S ribosomal protein L47, mitochondrial OS=Mus musculus GN=Mrpl47 PE=1 SV=2 Q9CY27 1 1 29,10 2,08E-01 137307,95 168038,66 148068,33 177086,61 246642,32 145631,46 172227,97 121832,49 144672,40 T-complex protein 1 subunit gamma OS=Mus musculus GN=Cct3 PE=1 SV=1 Q9CWZ7 1 1 28,75 2,10E-01 3781,39 0,00 31131,67 23222,75 27225,20 25460,70 25327,39 31020,92 23561,80 Immunoglobulin-binding protein 1 OS=Mus musculus GN=Igbp1 PE=1 SV=1 Q8C0L0 1 1 33,69 2,12E-01 45012,51 109320,49 166796,25 248580,15 214633,49 199714,73 112554,56 193137,46 200749,65 Tripeptidyl-peptidase 1 OS=Mus musculus GN=Tpp1 PE=1 SV=2 P18826 1 1 49,53 2,17E-01 0,00 744,48 467,12 18967,65 28325,58 17819,05 3005,58 2120,57 16531,78 Acylamino-acid-releasing enzyme OS=Mus musculus GN=Apeh PE=1 SV=3 Q9Z1X4 1 1 22,11 2,17E-01 2301,13 2220,08 4909,56 1536,77 2316,43 2789,88 2936,37 5097,22 1919,13 Thymosin beta-4 OS=Mus musculus GN=Tmsb4x PE=1 SV=1 Q9Z0F7 1 1 20,39 2,18E-01 37246,77 101389,75 102308,64 82366,56 79067,95 65215,07 92668,19 89826,56 77705,56 Beta-sarcoglycan OS=Mus musculus GN=Sgcb PE=1 SV=1 Q8K2Q5 2 1 63,09 2,18E-01 75647,48 84575,39 56641,50 83306,58 70365,38 80199,32 70972,51 39813,85 65143,88 Protein TBRG4 OS=Mus musculus GN=Tbrg4 PE=1 SV=1 O70311 1 1 34,87 2,18E-01 345714,49 349229,09 244312,98 356006,89 313107,18 264259,21 273524,74 564238,98 437742,55 Signal recognition particle receptor subunit beta OS=Mus musculus GN=Srprb PE=1 SV=1 Q62048 1 1 24,37 2,18E-01 24919,91 87143,63 70777,04 50859,21 53478,79 77116,12 234069,75 79829,18 63509,18 Tropomyosin alpha-1 chain OS=Mus musculus GN=Tpm1 PE=1 SV=1 Q62318 1 1 49,15 2,20E-01 19593,77 13467,89 1968,08 18309,57 20449,29 28847,93 9058,77 40105,55 21175,82 Keratin, type II cytoskeletal 2 oral OS=Mus musculus GN=Krt76 PE=1 SV=1 P62821 9 1 482,75 2,23E-01 54004,38 42993,03 61258,69 45533,89 47216,73 49648,24 51315,92 60088,99 48309,65 Muscleblind-like protein 2 OS=Mus musculus GN=Mbnl2 PE=2 SV=2 Q2NL51 1 1 75,98 2,23E-01 0,00 22891,72 93723,95 133096,24 273245,49 163623,50 12491,07 75394,16 163102,35 60S ribosomal protein L14 OS=Mus musculus GN=Rpl14 PE=1 SV=3 Q9CR42 1 1 42,55 2,24E-01 14928,81 1035,74 14431,81 7368,38 7471,66 4819,04 10646,36 16593,78 25196,42 Alpha-aminoadipic semialdehyde dehydrogenase OS=Mus musculus GN=Aldh7a1 PE=1 SV=4 P61255 2 1 81,79 2,25E-01 453728,09 403137,40 101762,40 83074,76 62777,57 68406,81 409732,43 110155,01 62487,66 Hemoglobin subunit beta-2 OS=Mus musculus GN=Hbb-b2 PE=1 SV=2 Q9CZY3 7 1 346,56 2,25E-01 1061257,54 1153703,16 735736,74 796410,52 770008,29 708160,29 902963,92 662495,62 823042,90 Bifunctional coenzyme A synthase OS=Mus musculus GN=Coasy PE=1 SV=2 Q8K0P3 1 1 26,74 2,28E-01 3252677,96 2804868,82 3302975,97 2552235,56 2238941,97 3009315,40 2409427,33 3057121,88 2132915,49 Heat shock 70 kDa protein 1B OS=Mus musculus GN=Hspa1b PE=1 SV=3 Q8BH69 1 1 70,64 2,30E-01 14656,36 30281,21 53858,26 66621,16 37812,62 48872,56 25167,35 16969,34 43497,37 NADH- 3 OS=Mus musculus GN=Cyb5r3 PE=1 SV=3 Q8K394 1 1 22,30 2,30E-01 267331,79 365388,37 235255,17 285936,81 294060,02 320836,97 242568,32 137160,79 388101,50 Alpha-enolase OS=Mus musculus GN=Eno1 PE=1 SV=3 Q9CQR6 2 1 68,38 2,33E-01 37499,39 37586,46 33108,11 29906,03 41328,27 38550,97 30712,07 28152,72 34790,77 Long-chain-fatty-acid--CoA ligase 1 OS=Mus musculus GN=Acsl1 PE=1 SV=2 Q91W89 1 1 31,77 2,34E-01 8905,65 7561,03 1825,92 2812,19 2268,45 5022,19 7340,39 4006,53 9530,49 FAD synthase OS=Mus musculus GN=Flad1 PE=1 SV=1 Q8BVA5 1 1 49,88 2,36E-01 44921,30 33459,80 57048,14 72185,78 51923,70 49904,12 50876,92 48719,08 29863,33 Glutamate--cysteine ligase regulatory subunit OS=Mus musculus GN=Gclm PE=1 SV=1 Q9WTI7 1 1 92,18 2,39E-01 14841,85 12971,47 40914,82 35223,41 58490,57 25992,98 19935,25 33208,52 48812,01 UPF0587 protein C1orf123 homolog OS=Mus musculus PE=1 SV=1 Q01339 1 1 46,25 2,40E-01 696266,73 433564,64 340227,78 330691,62 337321,80 217191,28 764713,27 226783,61 244959,47 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 P70389 1 1 25,87 2,43E-01 2523,71 3329,06 12821,87 3815,44 27414,30 6459,41 9449,07 2126,74 5446,12 Protein phosphatase 1K, mitochondrial OS=Mus musculus GN=Ppm1k PE=1 SV=1 Q61743 1 1 57,91 2,43E-01 7279,71 25338,74 38898,92 30675,97 44504,84 63618,68 31591,22 37261,10 67409,15 Methionine adenosyltransferase 2 subunit beta OS=Mus musculus GN=Mat2b PE=1 SV=1 Q5NBU8 1 1 21,85 2,43E-01 827541,60 291251,59 498227,17 683072,12 960256,91 471257,07 796066,83 336852,98 565382,29 Ribosome-releasing factor 2, mitochondrial OS=Mus musculus GN=Gfm2 PE=1 SV=2 Q8VC30 1 1 41,02 2,45E-01 28671,50 17292,01 45936,67 57175,73 23136,39 58557,23 107062,36 35486,69 54768,67 Translation machinery-associated protein 7 OS=Mus musculus GN=Tma7 PE=3 SV=1 Q8R1V4 2 1 76,44 2,46E-01 26115,04 24733,12 164861,50 107345,22 101347,72 57765,16 81773,41 160168,04 76552,69 5'-AMP-activated protein kinase subunit gamma-1 OS=Mus musculus GN=Prkag1 PE=1 SV=2 O35566 1 1 132,91 2,47E-01 145289,46 88104,37 218983,66 78949,31 107154,57 123740,91 111387,04 208449,64 74438,15 Isochorismatase domain-containing protein 1 OS=Mus musculus GN=Isoc1 PE=1 SV=1 O70503 1 1 50,23 2,48E-01 19593,35 16366,34 45579,90 47191,23 46296,06 96908,41 23055,97 21559,57 60298,57 Armadillo repeat-containing protein 1 OS=Mus musculus GN=Armc1 PE=1 SV=1 P21271 4 1 98,41 2,50E-01 258770,31 306776,41 323466,87 183584,63 217873,12 184278,85 513396,77 193716,94 203587,02 Integrin beta-1 OS=Mus musculus GN=Itgb1 PE=1 SV=1 Q7TNP2 12 1 434,98 2,50E-01 304102,84 339396,31 299446,30 236057,76 174885,01 165490,38 297681,17 287048,80 142729,21 Zinc-alpha-2-glycoprotein OS=Mus musculus GN=Azgp1 PE=1 SV=2 Q8CC21 1 1 45,69 2,50E-01 45291,39 36355,86 21338,27 34470,65 39251,26 17195,42 20700,29 25149,09 21435,93 39S ribosomal protein L3, mitochondrial OS=Mus musculus GN=Mrpl3 PE=1 SV=1 Q9CQN6 1 1 56,56 2,53E-01 8556,49 3420,53 857,41 3231,49 0,00 7046,88 3410,35 1120,33 3947,53 39S ribosomal protein L52, mitochondrial OS=Mus musculus GN=Mrpl52 PE=1 SV=1 P40936 2 1 131,86 2,56E-01 95020,29 55601,78 138758,98 95343,39 140559,18 99123,46 421299,66 63809,15 211739,90 ATP synthase subunit O, mitochondrial OS=Mus musculus GN=Atp5o PE=1 SV=1 Q00612 2 1 109,79 2,57E-01 5304,82 11189,05 3823,05 6298,26 9747,06 8356,85 72383,01 3299,56 7082,61 Solute carrier family 2, facilitated glucose transporter member 3 OS=Mus musculus GN=Slc2a3 PE=1 SV=1 E9Q173 3 1 76,47 2,57E-01 48455,14 20098,56 62285,12 71446,52 57126,35 37434,87 69348,49 36099,37 45336,17 5'-nucleotidase domain-containing protein 3 OS=Mus musculus GN=Nt5dc3 PE=1 SV=1 Q9ERF3 1 1 49,06 2,58E-01 23640,35 33135,43 28943,10 40728,75 47299,96 64330,40 29781,98 22760,87 67329,42 Phosphate carrier protein, mitochondrial OS=Mus musculus GN=Slc25a3 PE=1 SV=1 P61164 5 1 256,07 2,59E-01 77055,00 75013,93 110222,73 116148,86 107172,08 128274,25 65899,24 118577,26 131312,01 Izumo sperm-egg fusion protein 3 OS=Mus musculus GN=Izumo3 PE=1 SV=1 Q8BTZ7 1 1 25,75 2,60E-01 18640,15 7377,01 12858,18 8008,23 13973,68 15050,31 14933,04 15600,93 7396,29 Metaxin-1 OS=Mus musculus GN=Mtx1 PE=1 SV=1 P36536 2 1 133,54 2,61E-01 60077,02 58819,63 95563,39 103223,66 76445,03 169851,61 33642,47 129503,99 118988,88 Inosine-5'-monophosphate dehydrogenase 2 OS=Mus musculus GN=Impdh2 PE=1 SV=2 Q99KP6 3 1 107,47 2,61E-01 14943,86 19792,32 24816,54 40564,19 52017,45 58746,03 2333,00 20693,97 47476,89 Cytochrome c oxidase subunit 7A1, mitochondrial OS=Mus musculus GN=Cox7a1 PE=1 SV=1 Q62147 1 1 37,68 2,61E-01 137401,44 136977,96 140038,96 196070,01 216382,05 218861,10 86575,60 140486,46 215303,06 La protein homolog OS=Mus musculus GN=Ssb PE=1 SV=1 Q9CXE7 1 1 25,83 2,61E-01 3768,90 4036,73 9085,93 791,79 0,00 10402,21 6045,03 10499,85 4640,78 Endophilin-B1 OS=Mus musculus GN=Sh3glb1 PE=1 SV=1 Q9CQL5 1 1 22,97 2,66E-01 160259,51 83502,92 121868,28 110564,70 68940,45 70341,94 197509,32 247093,70 84284,25 Malate dehydrogenase, mitochondrial OS=Mus musculus GN=Mdh2 PE=1 SV=3 P83741 1 1 35,08 2,67E-01 12481,64 16828,28 10735,20 10362,76 10780,37 1924,74 8916,43 1332,11 14340,09 Membrane magnesium transporter 1 OS=Mus musculus GN=Mmgt1 PE=1 SV=1 Q8CGB6 2 1 83,97 2,68E-01 123438,97 70798,61 221905,87 251532,53 202349,99 239583,17 137889,57 296673,58 229732,41 Protein kinase C and casein kinase II substrate protein 3 OS=Mus musculus GN=Pacsin3 PE=1 SV=1 Q7TPR4 10 1 515,03 2,69E-01 19839,95 19143,98 20535,76 13953,41 11171,40 16506,23 23930,03 15238,69 13489,21 Aldehyde dehydrogenase X, mitochondrial OS=Mus musculus GN=Aldh1b1 PE=1 SV=1 P15864;P43275;Q071335 1 324,52 2,70E-01 2829463,73 3459792,41 3278331,05 2027422,20 2280224,37 3403544,98 3406941,95 3446452,73 2241950,57 Rab-interacting lysosomal protein OS=Mus musculus GN=Rilp PE=1 SV=1 Q8BP92 1 1 110,36 2,71E-01 3661,22 9356,97 12067,90 22900,02 17277,04 7968,97 2571,77 3411,19 12235,95 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Mus musculus GN=Ptrh2 PE=1 SV=1 P61961 1 1 101,57 2,72E-01 175910,50 222115,30 144144,73 223123,24 312891,57 355128,75 94214,42 110549,76 340035,96 Inorganic pyrophosphatase 2, mitochondrial OS=Mus musculus GN=Ppa2 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q921S7 2 1 85,82 2,76E-01 59663,92 96074,75 69097,24 68517,33 61854,88 80888,49 38127,14 57679,06 55606,84 Ras-related protein Rab-5B OS=Mus musculus GN=Rab5b PE=1 SV=1 P42232 1 1 33,48 2,77E-01 19270,29 2049,42 20228,53 22945,98 26184,95 19683,46 25015,11 7853,03 25481,12 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Mus musculus GN=Pdk1 PE=1 SV=2 Q8BJ71 2 1 68,87 2,78E-01 100855,64 179507,98 101970,68 164687,47 137137,73 213171,12 107283,41 74236,64 162113,62 Mannose-binding protein A OS=Mus musculus GN=Mbl1 PE=1 SV=1 Q8BP48 1 1 78,86 2,78E-01 7769,96 5836,70 9251,45 4602,09 3959,79 0,00 10276,60 9356,36 4094,24 LETM1 and EF-hand domain-containing protein 1, mitochondrial OS=Mus musculus GN=Letm1 PE=1 SV=1 Q99K48 2 1 72,28 2,78E-01 42524,77 81731,63 33854,73 62507,94 77517,21 140086,75 27600,42 64347,63 58868,65 Peroxisomal membrane protein 11B OS=Mus musculus GN=Pex11b PE=1 SV=1 P63037 3 1 84,55 2,79E-01 15245,63 27521,16 25532,48 41844,10 37502,57 42673,30 22829,01 24231,34 28338,36 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 Q0VBB0 1 1 32,49 2,81E-01 20677,63 22824,18 17790,16 18723,80 22370,21 15654,97 13344,20 12301,00 22419,69 28S ribosomal protein S27, mitochondrial OS=Mus musculus GN=Mrps27 PE=1 SV=2 Q8CI78 1 1 31,35 2,83E-01 142839,44 96415,55 16942,28 25626,12 25258,19 11858,69 54214,20 16638,15 11300,00 Fumarate hydratase, mitochondrial OS=Mus musculus GN=Fh PE=1 SV=3 E9Q7X6 1 1 27,92 2,83E-01 269579,19 378756,39 230638,21 453178,14 597191,69 383207,71 260264,75 246106,90 823416,00 Adenylate kinase 2, mitochondrial OS=Mus musculus GN=Ak2 PE=1 SV=5 Q6A0D4 2 1 63,36 2,86E-01 30583,51 29429,80 30310,49 8740,89 0,00 13364,22 10789,65 35042,42 14148,18 Protein S100-A10 OS=Mus musculus GN=S100a10 PE=1 SV=2 Q8BVW0 1 1 34,09 2,86E-01 4069,80 337,50 0,00 2552,68 3778,23 4711,72 3856,67 7419,69 45366,88 DNA-(apurinic or apyrimidinic site) lyase OS=Mus musculus GN=Apex1 PE=1 SV=2 Q3TCH7 1 1 31,58 2,86E-01 16017,61 16460,52 9084,46 15847,82 10056,73 17032,85 7196,62 9148,81 11948,96 Armadillo repeat-containing protein 10 OS=Mus musculus GN=Armc10 PE=1 SV=1 D3YYU8 1 1 38,11 2,88E-01 149201,42 189991,18 244115,87 205705,58 194340,88 243178,23 152198,52 290405,98 212582,37 kinase OS=Mus musculus GN=Rfk PE=1 SV=2 Q61187 2 1 65,47 2,91E-01 43621,73 50145,27 30987,38 43300,74 39089,96 40653,54 40515,46 21436,63 48612,71 Ecto-ADP-ribosyltransferase 3 OS=Mus musculus GN=Art3 PE=1 SV=2 Q91YJ5 3 1 102,41 2,92E-01 43253,61 47013,93 24412,49 74268,82 75688,86 49093,60 26477,21 50673,37 103606,92 Myosin-6 OS=Mus musculus GN=Myh6 PE=1 SV=2 O35737 5 1 291,62 2,92E-01 188059,24 175555,07 232363,17 250260,06 248236,69 227049,46 172373,88 200577,95 278007,12 LIM and cysteine-rich domains protein 1 OS=Mus musculus GN=Lmcd1 PE=1 SV=1 E9Q816 1 1 20,92 2,94E-01 126223,47 140607,77 135351,01 102767,74 87901,32 67247,85 59519,18 137261,21 158198,01 Heterogeneous nuclear ribonucleoprotein H2 OS=Mus musculus GN=Hnrnph2 PE=1 SV=1 P26262 1 1 32,14 2,96E-01 155314,21 57837,54 28539,54 40809,40 41209,03 24833,29 60154,02 19540,01 27215,28 Alpha-1-antitrypsin 1-2 OS=Mus musculus GN=Serpina1b PE=1 SV=2 P70372 1 1 61,93 2,96E-01 19047,39 4684,52 26485,44 13333,06 10918,21 48024,32 47368,03 50261,14 15535,53 Serine protease HTRA2, mitochondrial OS=Mus musculus GN=Htra2 PE=1 SV=2 Q64152 1 1 81,33 2,99E-01 292787,28 452884,98 317909,99 284447,17 282019,38 284139,71 338196,21 280949,97 316570,47 NAD(P)H dehydrogenase [quinone] 1 OS=Mus musculus GN=Nqo1 PE=1 SV=3 Q3UI43 1 1 93,24 3,00E-01 41064,61 35630,94 45443,22 29122,22 15854,53 35256,13 25482,20 22359,50 37862,55 Mitochondrial fission 1 protein OS=Mus musculus GN=Fis1 PE=1 SV=1 P62830 2 1 151,56 3,01E-01 84176,86 81262,15 88233,08 26868,12 18574,70 55801,84 155591,95 62789,36 20856,13 GrpE protein homolog 1, mitochondrial OS=Mus musculus GN=Grpel1 PE=1 SV=1 Q9DBR7 3 1 242,53 3,02E-01 5418,67 7090,01 9747,13 7285,34 6712,23 8334,06 11355,66 11589,75 6421,65 Ubiquitin carboxyl-terminal hydrolase 14 OS=Mus musculus GN=Usp14 PE=1 SV=3 P97477 3 1 72,39 3,03E-01 4394323,71 4290247,77 5507395,83 2848413,59 3334919,03 3612537,41 6417871,62 2637652,69 4616911,54 Splicing factor, proline- and glutamine-rich OS=Mus musculus GN=Sfpq PE=1 SV=1 Q60598 1 1 82,35 3,03E-01 39136,92 0,00 57434,70 109025,34 89335,28 49798,95 52323,61 88160,20 61384,55 Ig kappa chain V-III region PC 2880/PC 1229 OS=Mus musculus PE=1 SV=1 P63044 3 1 290,01 3,04E-01 100183,40 184467,03 156858,02 162125,53 178720,38 220540,02 160178,17 155986,09 138668,15 Charged multivesicular body protein 5 OS=Mus musculus GN=Chmp5 PE=1 SV=1 P70274 1 1 20,49 3,05E-01 63216,18 122168,25 24445,43 65308,26 155831,26 62565,02 197154,48 37158,21 181774,34 Elongation factor Ts, mitochondrial OS=Mus musculus GN=Tsfm PE=1 SV=1 Q9CY50 1 1 36,75 3,07E-01 45313,61 87955,96 81573,24 76125,73 63299,56 109854,49 61981,82 84824,51 81335,09 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 Q8R035 1 1 72,55 3,08E-01 92026,11 39353,41 34344,21 161204,02 97396,88 97881,72 79973,78 76501,56 88668,33 Kelch-like protein 31 OS=Mus musculus GN=Klhl31 PE=1 SV=1 Q8VEA4 1 1 34,06 3,09E-01 628599,81 711344,36 898302,79 504277,59 634927,90 535360,66 1338708,32 913925,74 363322,76 Myosin-7 OS=Mus musculus GN=Myh7 PE=1 SV=1 Q9QXA5 1 1 38,03 3,10E-01 113159,79 134786,68 91829,03 111844,03 113609,35 85426,44 127887,53 114026,35 182117,28 Calponin-1 OS=Mus musculus GN=Cnn1 PE=1 SV=1 Q9CX34 1 1 76,33 3,12E-01 36942,55 0,00 6134,10 27766,59 31415,24 37297,38 24815,32 1539,25 40352,53 Interferon kappa OS=Mus musculus GN=Ifnk PE=2 SV=1 P09541 3 1 143,87 3,13E-01 25079,08 25375,81 63182,83 21375,75 21722,83 30580,76 59448,53 32186,37 17535,54 Exportin-7 OS=Mus musculus GN=Xpo7 PE=1 SV=3 Q9Z0P5 1 1 80,39 3,15E-01 54024,35 61466,08 45404,77 64421,56 58537,91 57229,13 58028,90 92514,37 70266,20 Presequence protease, mitochondrial OS=Mus musculus GN=Pitrm1 PE=1 SV=1 Q9CY02 1 1 29,62 3,15E-01 19134,30 11316,01 6562,61 4986,38 7012,45 2393,98 24565,56 11243,08 7900,99 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 Q7TNG8 3 1 110,73 3,16E-01 45939,81 19952,28 20863,00 57454,79 58258,61 32914,78 13884,82 16763,45 69504,69 Protein quaking OS=Mus musculus GN=Qki PE=1 SV=1 Q9CRY7 1 1 53,34 3,17E-01 22182,91 2150,72 48544,76 61092,24 68530,28 34384,34 5254,52 12824,69 51540,94 Copine-7 OS=Mus musculus GN=Cpne7 PE=1 SV=1 Q8R550 3 1 139,92 3,23E-01 422131,40 587389,26 372290,83 406072,39 533351,78 287464,43 479267,58 370782,74 437337,24 Tyrosine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Yars PE=1 SV=3 Q8BKN6 1 1 20,97 3,24E-01 147053,88 169056,78 77288,87 156601,28 221478,14 117496,52 171974,09 103887,49 72123,45 40S ribosomal protein S27-like OS=Mus musculus GN=Rps27l PE=1 SV=3 P28660 2 1 82,80 3,26E-01 11847,24 4393,87 867,44 14508,43 13622,20 16694,41 6277,23 1662,84 12543,20 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Mus musculus GN=Sdha PE=1 SV=1 P56695 1 1 57,68 3,27E-01 0,00 3982,36 17931,63 8215,96 10953,41 28929,68 4355,08 8063,91 3759,31 60S ribosomal protein L7a OS=Mus musculus GN=Rpl7a PE=1 SV=2 P0C027 1 1 35,85 3,30E-01 52965,83 28027,87 46950,37 41513,05 21873,38 40493,59 37876,22 27062,61 34340,64 Exportin-1 OS=Mus musculus GN=Xpo1 PE=1 SV=1 Q8VD26 3 1 111,31 3,31E-01 355052,48 442397,42 588548,73 427340,86 656414,53 505927,58 410202,21 558375,39 509751,28 Protein deglycase DJ-1 OS=Mus musculus GN=Park7 PE=1 SV=1 Q9CPW4 1 1 60,66 3,31E-01 89562,76 183620,17 100376,23 106181,21 137207,69 156922,78 6816,61 60433,10 127855,71 Actin-related protein 3 OS=Mus musculus GN=Actr3 PE=1 SV=3 Q9Z2D6 1 1 45,95 3,33E-01 10151,83 18799,17 18784,26 9359,41 1691,85 20558,11 9783,58 6668,87 9226,17 Glutaryl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Gcdh PE=1 SV=2 P62892 1 1 22,57 3,38E-01 310933,73 333564,72 279079,02 201818,15 255833,85 281872,32 470884,79 384282,77 158621,59 Leucine-rich repeat-containing protein 47 OS=Mus musculus GN=Lrrc47 PE=1 SV=1 Q8K1J6 1 1 72,45 3,39E-01 33656,16 42700,06 10716,87 64952,58 26135,40 68148,85 140108,20 20054,32 51434,90 Malonyl-CoA decarboxylase, mitochondrial OS=Mus musculus GN=Mlycd PE=1 SV=1 Q64310 2 1 113,41 3,40E-01 3990,05 0,00 266589,70 69569,94 0,00 91067,22 246772,84 134735,83 138450,63 LIM domain-binding protein 3 OS=Mus musculus GN=Ldb3 PE=1 SV=1 Q9EPV8 1 1 41,53 3,44E-01 20492,47 23416,05 24342,30 25992,23 28362,60 21070,11 19673,98 29915,39 34299,24 Carbonyl reductase [NADPH] 2 OS=Mus musculus GN=Cbr2 PE=1 SV=1 Q69Z61 2 1 54,31 3,49E-01 1170338,48 1486,57 613,14 91322,00 746,51 159288,93 361417,60 130,47 48957,87 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 Q9ESW8 1 1 25,78 3,49E-01 2235,90 285,71 4177,01 3593,04 25354,37 4969,84 2607,08 15533,29 42806,72 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Mus musculus GN=Gng5 PE=1 SV=2 Q80UG5 1 1 75,87 3,55E-01 12808,49 14742,89 4519,36 24722,05 12078,88 12786,75 14753,41 12983,29 23657,72 Prolow-density lipoprotein receptor-related protein 1 OS=Mus musculus GN=Lrp1 PE=1 SV=1 Q9CQS4 1 1 89,28 3,57E-01 23111,07 14017,58 65673,43 65222,78 88775,72 54739,61 11934,32 52519,12 65640,25 Mitochondrial import inner membrane translocase subunit TIM44 OS=Mus musculus GN=Timm44 PE=1 SV=2 P63085 2 1 91,86 3,58E-01 116524,97 88089,16 39283,39 59547,40 42315,65 51251,49 106795,62 57367,09 68988,76 Sequestosome-1 OS=Mus musculus GN=Sqstm1 PE=1 SV=1 Q9DCN1 1 1 21,19 3,62E-01 6511,90 6938,47 1545,69 12735,48 35369,96 29590,26 3951,99 324,34 44875,41 ATP-dependent 6-phosphofructokinase, muscle type OS=Mus musculus GN=Pfkm PE=1 SV=3 Q9D6M3 2 1 102,20 3,67E-01 78648,01 136793,05 79597,16 120985,06 136033,90 90147,44 182629,43 84036,37 156277,23 Ras-related protein Rab-27B OS=Mus musculus GN=Rab27b PE=1 SV=3 Q9QXB9 1 1 55,87 3,67E-01 9883,04 13640,28 6205,82 12617,09 13002,25 20938,10 0,00 751,01 24131,38 Nuclear migration protein nudC OS=Mus musculus GN=Nudc PE=1 SV=1 Q8K4S1 1 1 24,97 3,69E-01 6029788,62 6726413,15 7025064,59 6222025,30 5152587,54 6167363,30 4714641,01 7647811,24 6004902,27 Eukaryotic translation initiation factor 3 subunit C OS=Mus musculus GN=Eif3c PE=1 SV=1 O35943 1 1 31,42 3,71E-01 774926,78 720629,27 764321,12 589174,14 572167,91 672677,88 468391,27 348883,60 806357,09 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Mus musculus GN=Nudt2 PE=1 SV=3 P62878 1 1 34,07 3,73E-01 144981,88 85688,54 103535,78 96710,63 90691,35 73923,43 57836,50 106345,46 62697,68 Ig alpha chain C region OS=Mus musculus PE=1 SV=1 Q9JI46 1 1 84,95 3,74E-01 161751,37 187651,09 119544,60 158439,94 186188,16 193456,87 105341,51 69507,11 367543,90 Heat shock factor-binding protein 1 OS=Mus musculus GN=Hsbp1 PE=1 SV=1 Q8BMP6 1 1 50,84 3,74E-01 15248,89 14415,00 16523,95 19706,41 4624,78 14115,94 8034,42 8926,92 19466,93 Omega- NIT2 OS=Mus musculus GN=Nit2 PE=1 SV=1 Q9ESK9 3 1 79,51 3,75E-01 100710,08 98642,76 83907,37 121051,15 91324,44 79388,99 74192,26 41428,12 92453,29 Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Mus musculus GN=Anp32a PE=1 SV=1 Q5SRX1 1 1 46,13 3,76E-01 84343,39 102535,68 82016,92 94506,97 34214,68 85562,39 64125,69 74596,88 110581,99 Tripartite motif-containing protein 54 OS=Mus musculus GN=Trim54 PE=1 SV=1 P15508 5 1 129,33 3,79E-01 29839,35 29443,44 26773,19 22635,90 18455,37 19467,98 33318,71 7579,44 17727,37 Eukaryotic translation initiation factor 2A OS=Mus musculus GN=Eif2a PE=1 SV=2 Q61656 5 1 137,20 3,79E-01 51165,82 68358,67 48387,06 67559,13 66485,48 66157,92 38006,08 48258,45 64564,61 Lactoylglutathione lyase OS=Mus musculus GN=Glo1 PE=1 SV=3 Q62313 1 1 98,28 3,80E-01 8796,72 14928,59 10595,34 10295,49 11235,18 10939,14 10930,43 16127,63 9988,41 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase OS=Mus musculus GN=Dhdh PE=1 SV=1 Q9R0Q3 1 1 60,58 3,81E-01 215831,47 203303,02 367828,62 180073,98 183248,74 221600,57 183532,35 272262,10 113286,25 Ubiquitin domain-containing protein UBFD1 OS=Mus musculus GN=Ubfd1 PE=1 SV=2 Q9QZ08 1 1 31,53 3,82E-01 25756,70 30735,72 28374,39 34313,17 36551,69 36638,60 29855,41 20102,11 61709,37 Proteasome subunit alpha type-3 OS=Mus musculus GN=Psma3 PE=1 SV=3 Q9D0R8 1 1 58,94 3,84E-01 24048,64 13349,57 19719,07 17112,93 19530,67 14391,93 33987,92 25071,23 22706,96 Keratin, type II cytoskeletal 79 OS=Mus musculus GN=Krt79 PE=1 SV=2 Q6ZPG2 1 1 30,13 3,88E-01 20834,59 15632,93 23264,27 13385,97 7475,90 19051,41 31956,84 43421,26 10820,67 Keratin, type II cytoskeletal 1b OS=Mus musculus GN=Krt77 PE=1 SV=1 Q62418 1 1 60,29 3,89E-01 34010,10 44425,78 59183,44 77016,97 49417,25 46852,10 38845,52 36378,75 59812,52 Janus kinase and microtubule-interacting protein 3 OS=Mus musculus GN=Jakmip3 PE=1 SV=2 Q6WVG3 1 1 26,30 3,90E-01 46670,33 71953,23 26553,58 35899,05 61987,39 81621,00 12672,47 24513,93 45829,79 [Protein ADP-ribosylarginine] hydrolase-like protein 1 OS=Mus musculus GN=Adprhl1 PE=1 SV=1 Q9D024 3 1 71,59 3,91E-01 14492,16 0,00 16659,93 24035,18 6887,30 22657,85 8395,36 3316,19 10944,40 28S ribosomal protein S5, mitochondrial OS=Mus musculus GN=Mrps5 PE=1 SV=1 Q8VE47 1 1 40,69 3,93E-01 41382,26 1,43 8387,17 31444,54 2847,29 10347,66 19941,66 11565,84 34133,10 Methylglutaconyl-CoA hydratase, mitochondrial OS=Mus musculus GN=Auh PE=1 SV=1 Q91YH5 1 1 54,16 3,93E-01 56224,54 79845,78 162790,34 43773,64 40173,28 49633,84 105129,52 304187,58 39200,84 Membrane-associated progesterone receptor component 2 OS=Mus musculus GN=Pgrmc2 PE=1 SV=2 P01750 2 1 55,39 3,95E-01 35854,98 16258,96 3805,92 7203,95 4275,63 5668,50 18445,87 10351,14 5200,83 Isochorismatase domain-containing protein 2A, mitochondrial OS=Mus musculus GN=Isoc2a PE=1 SV=1 Q80ZS3 2 1 77,07 3,96E-01 70609,58 91622,68 51225,76 71333,51 60140,07 60885,95 40959,08 59915,32 56155,59 Apolipoprotein A-I OS=Mus musculus GN=Apoa1 PE=1 SV=2 P68372 23 1 2048,90 3,97E-01 1888297,83 1550839,88 1094545,80 1589809,03 1966457,39 2219130,44 2208203,10 1359951,32 1933672,03 Mitochondrial peptide methionine sulfoxide reductase OS=Mus musculus GN=Msra PE=1 SV=1 Q91XL9 1 1 48,73 3,97E-01 896,74 0,00 92008,27 61236,81 72572,72 58155,34 37412,24 47280,68 112015,54 Serine protease inhibitor A3M OS=Mus musculus GN=Serpina3m PE=1 SV=2 Q91VS7 1 1 60,24 3,97E-01 74056,70 44924,77 95017,77 94016,34 67507,72 93035,49 208911,03 86243,49 62541,28 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Mus musculus GN=Atp2a2 PE=1 SV=2 Q05D44 1 1 23,99 3,98E-01 50371,21 42061,03 43543,46 48030,54 74969,82 38637,72 46442,67 30150,30 42477,63 Proteasome subunit beta type-9 OS=Mus musculus GN=Psmb9 PE=1 SV=1 Q8K2H2 2 1 51,27 4,01E-01 883373,11 377369,11 781793,62 413740,05 484017,32 458239,78 768831,21 452741,66 558495,76 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Mus musculus GN=Bdh1 PE=1 SV=2 P17932 1 1 30,52 4,01E-01 21256,90 32642,39 0,00 24390,74 22279,96 45852,35 28506,53 15641,53 13651,67 Obg-like ATPase 1 OS=Mus musculus GN=Ola1 PE=1 SV=1 P02104 4 1 159,23 4,04E-01 318222,85 338103,48 65745,91 62783,34 65879,22 55533,68 538728,68 96450,32 58993,91 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 P01787 1 1 65,18 4,05E-01 0,00 0,00 0,00 4580,08 0,00 0,00 0,00 5337,61 0,00 Cytochrome b-c1 complex subunit 8 OS=Mus musculus GN=Uqcrq PE=1 SV=3 Q3UMU9 3 1 116,47 4,05E-01 5464,34 6125,79 7602,02 5695,20 4964,88 5290,79 8318,43 5683,10 5406,73 Ubiquitin thioesterase OTUB1 OS=Mus musculus GN=Otub1 PE=1 SV=2 Q80W54 3 1 100,01 4,05E-01 30481,73 17876,07 71749,78 77038,14 83598,07 29451,95 31970,01 16577,27 39127,34 Cytochrome c-type heme lyase OS=Mus musculus GN=Hccs PE=1 SV=2 Q60674 1 1 28,29 4,06E-01 3639746,33 1532096,81 358079,20 522626,35 855832,64 336439,88 1853127,01 674328,53 797063,66 Metalloreductase STEAP4 OS=Mus musculus GN=Steap4 PE=1 SV=1 Q9WVA2 1 1 48,50 4,08E-01 1548719,46 1682120,90 1721379,62 1634929,08 1918166,59 1540031,84 1507311,43 1670459,87 1974019,36 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Mus musculus GN=Suclg1 PE=1 SV=4 Q8BHL8 1 1 43,21 4,09E-01 96621,73 159535,33 83247,02 95900,35 64155,84 93307,16 140692,34 24739,86 100008,34 Four and a half LIM domains protein 2 OS=Mus musculus GN=Fhl2 PE=1 SV=1 Q99MR6 1 1 54,00 4,10E-01 7133,70 5038,59 1031,32 7040,43 344,29 9839,89 785,54 863,00 612,27 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Mus musculus GN=Aasdhppt PE=1 SV=1 Q8BSM7 1 1 38,07 4,10E-01 140104,39 157548,84 35575,70 40510,71 36576,99 26399,20 165318,36 42578,72 25701,48 Complement component C1q receptor OS=Mus musculus GN=Cd93 PE=1 SV=1 P01902 2 1 86,48 4,11E-01 10749,12 10636,46 5827,12 6158,28 10157,62 76980,21 4083,20 14841,07 8268,02 Septin-2 OS=Mus musculus GN=Sept2 PE=1 SV=2 Q99K28 1 1 33,07 4,12E-01 45589,75 51385,97 60135,11 91247,64 38811,98 71686,52 43776,29 56682,48 63543,37 Coagulation factor XII OS=Mus musculus GN=F12 PE=1 SV=2 Q8R105 1 1 49,47 4,14E-01 12498,39 15550,69 10508,00 14105,25 10963,15 12518,93 21220,50 12301,88 29148,70 Uncharacterized protein C19orf44 homolog OS=Mus musculus PE=1 SV=2 P56501 1 1 105,51 4,14E-01 0,00 23136,55 17749,21 15780,55 27750,59 35888,87 21912,50 76735,96 41853,95 Major prion protein OS=Mus musculus GN=Prnp PE=1 SV=2 Q99LT0 1 1 56,80 4,15E-01 42095,23 75452,68 0,00 40387,26 35059,86 26516,95 47952,03 72644,85 46627,02 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Mus musculus GN=Ndufa9 PE=1 SV=2 Q811Q9 1 1 40,69 4,17E-01 14155,73 25579,71 13661,70 39679,93 31413,12 17852,37 11010,75 11176,85 16058,98 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus GN=Oxct1 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P60603 2 1 106,28 4,19E-01 0,00 19148,68 56387,56 33098,17 20546,79 32707,60 47910,23 91132,03 12758,46 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Mus musculus GN=Gspt1 PE=1 SV=2 Q9QWR8 1 1 20,07 4,25E-01 1690,14 16480,29 14706,20 17436,58 12292,98 25764,58 7107,15 11350,49 15326,71 Fructose-bisphosphate OS=Mus musculus GN=Aldob PE=1 SV=3 P35278 4 1 198,60 4,27E-01 102092,47 46866,47 86930,39 47023,18 45643,03 65197,60 79451,91 58564,95 54384,28 Pituitary tumor-transforming gene 1 protein-interacting protein OS=Mus musculus GN=Pttg1ip PE=1 SV=1 O35930 1 1 67,98 4,28E-01 5608,12 1910,70 0,00 0,00 0,00 47795,03 4710,02 2309,74 0,00 Reticulon-4-interacting protein 1, mitochondrial OS=Mus musculus GN=Rtn4ip1 PE=1 SV=2 Q00PI9 1 1 85,12 4,28E-01 6504,60 7202,27 15566,75 5412,54 2752,84 8400,58 5576,86 15248,61 4715,63 Target of Myb protein 1 OS=Mus musculus GN=Tom1 PE=1 SV=1 Q6PGC1 1 1 29,63 4,30E-01 10166090,08 4759639261,82 888236293,91 450295939,15 973862341,74 2379776,85 3300165409,79 1259120570,56 439846643,25 Dynamin-2 OS=Mus musculus GN=Dnm2 PE=1 SV=2 Q8BIG7 2 1 59,01 4,33E-01 28827,26 31559,92 33026,99 31364,56 33093,41 37586,06 39771,54 40428,90 37558,75 Hsc70-interacting protein OS=Mus musculus GN=St13 PE=1 SV=1 Q9QUR7 1 1 112,16 4,36E-01 115808,87 197960,19 160288,49 135940,43 145743,70 160843,99 68764,78 87615,96 167179,05 Cytochrome b5 OS=Mus musculus GN=Cyb5a PE=1 SV=2 Q8C1B7 3 1 116,59 4,38E-01 26823,39 31608,04 32973,39 25598,43 19742,72 29268,80 12742,58 21124,86 34283,85 40S ribosomal protein S6 OS=Mus musculus GN=Rps6 PE=1 SV=1 Q8K440 3 1 83,45 4,41E-01 135753601,39 123860252,96 23236531,59 29771185,42 26277946,49 20162352,10 177749458,61 43784072,85 24305165,33 Serum deprivation-response protein OS=Mus musculus GN=Sdpr PE=1 SV=3 Q6P8M1 2 1 101,88 4,42E-01 10466,81 26116,17 14786,59 10228,59 11400,73 11699,66 11320,73 8890,94 12234,13 Alpha-1-antitrypsin 1-4 OS=Mus musculus GN=Serpina1d PE=1 SV=1 Q9CQS8 2 1 104,63 4,42E-01 137908,38 56988,00 46720,12 60333,05 67466,27 69938,57 72450,11 71883,37 48044,48 Ras-related protein R-Ras OS=Mus musculus GN=Rras PE=1 SV=1 Q8CG72 1 1 34,76 4,45E-01 13011,17 32575,39 41902,75 28867,34 29627,57 22942,66 18609,61 4325,02 25451,08 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadsb PE=1 SV=1 P70460 1 1 73,29 4,49E-01 52671,12 55847,24 27069,45 15270,22 22673,70 50523,44 44544,75 14910,44 18556,94 Cytochrome c oxidase subunit 2 OS=Mus musculus GN=Mtco2 PE=1 SV=1 Q6PE15 1 1 87,96 4,50E-01 23868,47 8338,29 16908,72 44298,05 12899,35 41559,61 34244,77 30061,63 24566,01 A-kinase anchor protein 2 OS=Mus musculus GN=Akap2 PE=1 SV=3 Q9WTQ8 1 1 44,74 4,51E-01 2184,92 5617,50 4259,38 10905,76 11728,39 10779,16 6962,33 20765,28 7756,89 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=1 SV=1 Q61292 2 1 85,37 4,52E-01 22261,77 0,00 20883,16 24818,34 22527,24 18541,25 23477,59 13624,60 15401,05 MICOS complex subunit Mic25 OS=Mus musculus GN=Chchd6 PE=1 SV=2 Q9DB34 2 1 63,77 4,53E-01 34065,49 43192,80 21113,61 20411,33 54541,49 0,00 36548,37 9949,69 31190,07 Protein-cysteine N-palmitoyltransferase HHAT-like protein OS=Mus musculus GN=Hhatl PE=1 SV=2 Q791T5 1 1 29,17 4,53E-01 271,59 4745,42 67519,04 12166,47 59561,29 20815,08 7793,91 76626,40 15773,88 26S proteasome non-ATPase regulatory subunit 6 OS=Mus musculus GN=Psmd6 PE=1 SV=1 Q8CGA0 1 1 34,83 4,54E-01 46194,46 37424,11 56808,10 53007,16 37864,00 27611,59 34531,08 55618,50 47366,30 Cdc42-interacting protein 4 OS=Mus musculus GN=Trip10 PE=1 SV=2 Q1ERP8 1 1 63,86 4,57E-01 32893,50 57968,18 28952,05 59718,15 75510,17 26325,23 46074,28 58399,32 66688,06 Proline synthase co-transcribed bacterial homolog protein OS=Mus musculus GN=Prosc PE=1 SV=1 P23198 1 1 91,36 4,58E-01 175523,76 146431,42 200552,75 191156,12 271237,42 268941,70 155059,46 154672,06 284576,53 40S ribosomal protein S10 OS=Mus musculus GN=Rps10 PE=1 SV=1 Q8BTX9 1 1 44,96 4,59E-01 20863,09 26027,20 42011,90 29987,77 52879,05 31065,16 27309,28 66076,98 40977,06 OS=Mus musculus GN=Anxa2 PE=1 SV=2 P28652 2 1 100,16 4,59E-01 57724,29 56351,83 56441,46 49509,06 55112,93 61123,99 85206,34 48342,70 52275,20 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 Q8C0X0 2 1 50,55 4,60E-01 58162,95 42911,31 32757,57 48283,03 35153,36 37431,23 35711,18 8138,46 41038,43 Synaptopodin-2 OS=Mus musculus GN=Synpo2 PE=1 SV=2 Q9ES83 2 1 82,92 4,66E-01 319142,59 355823,39 323508,47 301858,08 301476,68 267885,75 376941,47 223643,55 282881,48 Integrin beta-3 OS=Mus musculus GN=Itgb3 PE=1 SV=2 Q8C050 2 1 48,51 4,66E-01 200743,75 163606,24 301488,20 232232,26 330254,78 215862,77 313684,39 387256,38 196972,24 Proteasome subunit beta type-5 OS=Mus musculus GN=Psmb5 PE=1 SV=3 P63248 2 1 113,47 4,70E-01 3505,67 15540,24 7815,63 8800,80 9114,18 9498,07 17671,11 6263,80 1603,74 Aspartate aminotransferase, mitochondrial OS=Mus musculus GN=Got2 PE=1 SV=1 Q8VE70 1 1 86,37 4,70E-01 50138,91 67137,79 67636,90 11124,08 1755,39 11832,01 0,00 37204,29 42810,27 DnaJ homolog subfamily A member 3, mitochondrial OS=Mus musculus GN=Dnaja3 PE=1 SV=1 Q3TCJ1 1 1 33,55 4,70E-01 11028,53 29460,27 5669,43 17501,48 7040,66 11065,12 18191,01 17035,32 6811,26 Alpha-sarcoglycan OS=Mus musculus GN=Sgca PE=1 SV=1 P59266 1 1 29,07 4,71E-01 52062,34 85306,54 82745,86 99833,33 28024,68 42186,55 89003,98 87354,27 84911,51 Probable cysteine--tRNA ligase, mitochondrial OS=Mus musculus GN=Cars2 PE=1 SV=2 Q9Z1T1 2 1 51,13 4,72E-01 69062,22 6976,50 3471,10 3641,40 5750,41 0,00 0,00 2668,07 3490,44 Probable ATP-dependent RNA helicase DDX6 OS=Mus musculus GN=Ddx6 PE=1 SV=1 Q8VED9 1 1 54,17 4,75E-01 64513,62 51528,97 45615,46 57185,85 49831,48 60350,04 15917,47 38944,76 53170,07 Myosin light chain kinase 3 OS=Mus musculus GN=Mylk3 PE=1 SV=1 Q9JM14 1 1 38,69 4,75E-01 37041,39 50965,26 58824,08 43534,20 47506,53 33304,84 47302,08 39004,03 35511,82 Ras-related protein Rab-12 OS=Mus musculus GN=Rab12 PE=1 SV=3 P47740 1 1 44,70 4,76E-01 130089,72 72111,20 54189,13 119136,80 80799,99 84964,55 51933,07 81840,33 94633,93 Acyl-coenzyme A thioesterase 9, mitochondrial OS=Mus musculus GN=Acot9 PE=1 SV=1 Q9CWS1 1 1 26,56 4,77E-01 3059078,03 2145117,18 2743681,23 2464825,22 3005825,62 2446201,11 5809475,93 4122670,61 2024736,33 Alpha-methylacyl-CoA racemase OS=Mus musculus GN=Amacr PE=1 SV=4 P60122 1 1 59,26 4,78E-01 6876,19 25977,77 16224,36 14301,96 20611,51 35282,21 17749,33 23550,64 8730,79 Aminopeptidase N OS=Mus musculus GN=Anpep PE=1 SV=4 P35293 1 1 74,67 4,79E-01 159690,46 197877,15 120858,36 153545,57 173231,69 179309,76 147778,64 151209,69 159939,75 60S ribosomal protein L13 OS=Mus musculus GN=Rpl13 PE=1 SV=3 Q9JLB0 2 1 55,22 4,80E-01 2856,25 2047,33 6489,25 10975,76 356,84 2043,18 3435,79 9307,44 8951,83 Serine--tRNA ligase, mitochondrial OS=Mus musculus GN=Sars2 PE=1 SV=2 Q9CQW1 1 1 30,47 4,82E-01 269932,10 146992,99 150420,69 189943,66 215832,54 160537,21 143343,68 118314,11 213374,68 Aflatoxin B1 aldehyde reductase member 2 OS=Mus musculus GN=Akr7a2 PE=1 SV=3 P13595 2 1 61,84 4,82E-01 473453,49 792282,00 597369,76 472960,12 450920,12 374131,35 297981,95 511522,05 675638,10 Myosin-binding protein C, cardiac-type OS=Mus musculus GN=Mybpc3 PE=1 SV=1 P16015 2 1 71,26 4,83E-01 31756,31 10996,59 41450,80 36578,23 4994,23 2781,79 14562,54 3083,13 735,04 Estradiol 17-beta-dehydrogenase 8 OS=Mus musculus GN=Hsd17b8 PE=1 SV=2 Q9QYB5 1 1 34,76 4,84E-01 41733,14 41396,06 33944,16 20377,84 43898,76 27669,09 25463,57 18669,66 28459,85 Four and a half LIM domains protein 1 OS=Mus musculus GN=Fhl1 PE=1 SV=3 Q8C6I2 1 1 27,09 4,85E-01 11701,79 7651,56 0,00 6472,48 6128,13 0,00 8414,00 13587,60 6072,38 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Mus musculus GN=Ppp6r3 PE=1 SV=1 Q8K0C8 1 1 28,35 4,85E-01 101448,04 30641,57 22661,44 34810,42 30107,47 32786,14 23578,80 28937,70 21052,65 Exportin-2 OS=Mus musculus GN=Cse1l PE=1 SV=1 Q8C9V1 1 1 25,17 4,85E-01 20527907,59 8967402,83 4218556,44 7746142,10 10836760,85 8014726,76 32715919,44 7024257,39 6655730,02 D-dopachrome decarboxylase OS=Mus musculus GN=Ddt PE=1 SV=3 Q9CYG7 1 1 22,59 4,87E-01 7593,47 13508,59 12155,06 9938,78 14146,97 21119,47 9563,29 12437,49 18181,08 N-alpha-acetyltransferase 50 OS=Mus musculus GN=Naa50 PE=1 SV=1 P21279 2 1 63,54 4,89E-01 45157,43 50253,52 22207,92 40778,63 35283,73 35470,42 55995,54 15149,24 34420,52 Microtubule-associated protein RP/EB family member 1 OS=Mus musculus GN=Mapre1 PE=1 SV=3 Q62093 1 1 49,42 4,90E-01 49424,68 56377,22 7401,42 19786,06 36136,42 40964,15 30611,46 12157,71 5156,52 phosphoribosyltransferase OS=Mus musculus GN=Aprt PE=1 SV=2 Q62165 1 1 36,01 4,92E-01 11302,41 7128,94 45917,58 38436,58 17149,98 24338,25 20589,38 19646,84 24390,20 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Mus musculus GN=Uchl5 PE=1 SV=2 P04444 2 1 59,03 4,92E-01 969451,68 627888,43 78365,66 113547,29 151127,92 160113,43 495848,81 114578,26 111861,04 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Mus musculus GN=Ndufa13 PE=1 SV=3 P97429 2 1 89,06 4,93E-01 15574,34 0,00 0,00 8644,14 15349,68 4794,71 21242,72 0,00 8166,97 Synaptotagmin-like protein 2 OS=Mus musculus GN=Sytl2 PE=1 SV=2 Q64518 12 1 757,22 4,95E-01 3765,76 1535,36 1841,36 1743,62 1118,74 5051,02 8027,10 3787,29 1795,37 Multimerin-2 OS=Mus musculus GN=Mmrn2 PE=1 SV=1 Q8CBY8 1 1 29,06 5,00E-01 21117,10 42608,81 14735,15 22758,45 34101,16 34290,81 12147,68 32152,90 24460,23 Protein kinase C alpha type OS=Mus musculus GN=Prkca PE=1 SV=3 Q9WV96 1 1 30,68 5,00E-01 45877,66 42267,20 29613,26 20902,98 45916,45 34958,00 39263,08 40055,37 38987,67 OS=Mus musculus GN=Srl PE=1 SV=1 A2AN08 1 1 29,84 5,00E-01 12944,02 10859,09 1698,30 10144,05 6612,66 6281,79 18402,18 6892,33 9214,74 General vesicular transport factor p115 OS=Mus musculus GN=Uso1 PE=1 SV=2 P98156 1 1 32,80 5,03E-01 0,00 47267,49 62455,14 50550,21 0,00 39809,97 70129,10 37173,99 75733,53 Protein disulfide-isomerase TMX3 OS=Mus musculus GN=Tmx3 PE=1 SV=2 Q8BL03 1 1 49,53 5,04E-01 475,05 4537,99 3056,56 22449,73 3216,00 16065,74 5393,86 607,44 4718,44 2-oxoglutarate dehydrogenase, mitochondrial OS=Mus musculus GN=Ogdh PE=1 SV=3 Q9R000 1 1 45,27 5,08E-01 33975,44 65303,55 30912,40 52953,07 80672,08 43058,54 33675,83 17783,92 53398,39 Pumilio domain-containing protein KIAA0020 OS=Mus musculus GN=Kiaa0020 PE=1 SV=2 Q8VDQ8 1 1 48,66 5,08E-01 13795,65 14285,07 36223,48 6363,65 17975,54 7995,00 17018,90 4328,08 7856,35 Cytochrome b-c1 complex subunit 1, mitochondrial OS=Mus musculus GN=Uqcrc1 PE=1 SV=2 Q8BGI7 1 1 40,70 5,08E-01 25990,74 0,00 28907,04 12071,09 21069,32 23917,38 22674,60 54180,94 5119,20 Ubinuclein-1 OS=Mus musculus GN=Ubn1 PE=2 SV=1 Q8CBY0 1 1 57,96 5,10E-01 44242,87 85861,72 64185,30 82258,53 98898,06 98352,63 26216,26 51823,58 104930,50 40S ribosomal protein S4, X isoform OS=Mus musculus GN=Rps4x PE=1 SV=2 P62900 2 1 65,48 5,11E-01 516037,10 143425,16 8789,71 48917,03 432,24 55349,33 16674,41 86809,45 16777,61 Lysophosphatidic type 6 OS=Mus musculus GN=Acp6 PE=1 SV=1 Q812A2 2 1 50,87 5,13E-01 898755,03 1061161,31 966950,47 717124,13 705982,84 913850,29 1135614,69 910072,28 524439,88 Actin, alpha cardiac muscle 1 OS=Mus musculus GN=Actc1 PE=1 SV=1 Q9DD18 1 1 113,01 5,15E-01 30123,26 969,07 62928,53 34295,63 34640,76 52011,87 33915,81 24819,74 45434,46 Actin, alpha skeletal muscle OS=Mus musculus GN=Acta1 PE=1 SV=1 Q91V79 1 1 69,18 5,22E-01 148973,92 208738,16 124550,60 119551,29 108413,38 156998,38 138695,39 122066,10 106715,81 Cell cycle and apoptosis regulator protein 2 OS=Mus musculus GN=Ccar2 PE=1 SV=2 P60824 1 1 34,84 5,22E-01 19564,05 64449,40 53178,34 46764,33 71019,92 71286,92 41803,98 77125,44 108678,10 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Mus musculus GN=Pdhb PE=1 SV=1 P50431 2 1 111,71 5,24E-01 127865,84 61514,44 59174,67 288638,30 134050,67 206907,40 18531,67 138249,39 215705,69 60 kDa heat shock protein, mitochondrial OS=Mus musculus GN=Hspd1 PE=1 SV=1 P70697 1 1 60,49 5,25E-01 15023,40 11114,20 13177,93 9285,26 8752,18 15005,16 0,00 3160,15 35880,27 Serine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Sars PE=1 SV=3 P03976 1 1 55,42 5,26E-01 21376,32 66821,72 40442,15 16929,41 11762,54 13644,47 8535,66 504133,35 7790,26 Protein SET OS=Mus musculus GN=Set PE=1 SV=1 Q9D783 1 1 61,34 5,27E-01 3906,88 12160,42 901,13 13089,28 16144,81 8089,29 1949,81 0,00 15976,30 MICOS complex subunit Mic26 OS=Mus musculus GN=Apoo PE=1 SV=2 O70139 1 1 62,43 5,30E-01 24759,60 66409,49 63697,93 45580,43 42471,02 109407,29 42645,14 52829,37 38854,52 Heat shock protein beta-6 OS=Mus musculus GN=Hspb6 PE=1 SV=1 Q8BUV3 1 1 44,52 5,31E-01 0,00 0,00 36282,15 0,00 13316,23 21240,20 0,00 19170,79 17783,38 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 Q9CQT1 1 1 40,18 5,32E-01 63918,34 29830,20 16442,08 19589,71 37555,58 15137,97 43282,99 41007,19 26199,50 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dlat PE=1 SV=2 Q8BVU5 2 1 68,71 5,32E-01 25042,64 0,00 10564,73 3002,83 22586,30 5077,82 11332,35 34987,97 9755,37 Branched-chain-amino-acid aminotransferase, mitochondrial OS=Mus musculus GN=Bcat2 PE=1 SV=2 Q9CR13 1 1 28,37 5,35E-01 255766,65 285529,43 253201,70 248840,09 228579,63 191243,76 241494,14 162479,11 387464,19 Paraplegin OS=Mus musculus GN=Spg7 PE=1 SV=1 P70698 1 1 49,26 5,37E-01 3417,37 0,00 301,43 0,00 8276,81 0,00 0,00 3100,13 0,00 SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Mus musculus GN=Slirp PE=1 SV=2 P07361 1 1 42,89 5,37E-01 66907,20 1782,72 1515,21 18372,37 293610,64 148732,04 49100,84 257508,17 1498,73 Mitochondrial Rho GTPase 2 OS=Mus musculus GN=Rhot2 PE=1 SV=1 Q9DCI9 1 1 38,93 5,39E-01 106587,16 67783,31 81740,33 66116,07 102585,45 101456,92 65283,48 57087,49 102069,84 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Mus musculus GN=Gpx4 PE=1 SV=4 P46414 1 1 86,78 5,41E-01 13574,24 16706,87 20219,59 24548,38 27262,00 15651,65 13181,64 17345,52 25029,63 Calponin-3 OS=Mus musculus GN=Cnn3 PE=1 SV=1 Q91VR7 2 1 45,99 5,41E-01 131254,01 31809,72 110851,39 246038,84 147559,07 152766,21 70295,48 92561,19 211073,87 Adrenodoxin-like protein, mitochondrial OS=Mus musculus GN=Fdx1l PE=1 SV=1 Q62393 1 1 68,63 5,41E-01 9462,62 77613,10 72142,39 90058,83 52279,31 59374,12 16377,74 23580,96 52110,89 Calcium-independent -gamma OS=Mus musculus GN=Pnpla8 PE=1 SV=1 Q61553 1 1 38,77 5,41E-01 37481,44 63,30 34466,41 6617,73 76,80 5459,99 1495,16 39293,77 5492,26 A-kinase anchor protein 12 OS=Mus musculus GN=Akap12 PE=1 SV=1 Q99N94 1 1 52,68 5,41E-01 28167,26 68635,17 38670,13 61256,48 75859,89 47375,12 38924,73 50880,93 46619,39 Far upstream element-binding protein 1 OS=Mus musculus GN=Fubp1 PE=1 SV=1 Q07813 1 1 43,29 5,43E-01 32179,33 35752,85 58990,80 64427,81 55032,73 43841,89 31915,22 22133,04 63512,81 Trem-like transcript 1 protein OS=Mus musculus GN=Treml1 PE=1 SV=2 A2ADY9 1 1 48,33 5,44E-01 27901,17 9066,92 25835,08 26580,10 4898,26 25500,40 3927,93 15338,24 5674,49 Collagen alpha-1(VI) chain OS=Mus musculus GN=Col6a1 PE=1 SV=1 Q8C1A5 1 1 54,32 5,47E-01 6489,72 5046,92 7288,59 12245,08 17288,82 5957,84 7249,20 15491,34 15091,05 FUN14 domain-containing protein 2 OS=Mus musculus GN=Fundc2 PE=1 SV=1 Q8BJU2 1 1 25,23 5,48E-01 1418,61 2908,14 3600,34 2403,55 2073,66 3831,43 4374,67 6709,75 2005,67 THO complex subunit 4 OS=Mus musculus GN=Alyref PE=1 SV=3 P97355 1 1 32,49 5,50E-01 7233,91 9307,03 12202,54 13087,25 14040,33 8723,65 14447,02 3799,61 18644,21 Extracellular superoxide dismutase [Cu-Zn] OS=Mus musculus GN=Sod3 PE=1 SV=1 P27600;P27601 4 1 135,79 5,53E-01 4510505,00 5322337,00 5033288,18 3318532,11 3866077,68 4019123,38 5707642,51 4724152,52 2697981,32 Charged multivesicular body protein 4b OS=Mus musculus GN=Chmp4b PE=1 SV=2 P00416 1 1 96,82 5,55E-01 1071159,98 433228,76 1256199,48 820640,25 706917,53 712197,33 2496586,40 3164868,34 424217,61 AFG3-like protein 2 OS=Mus musculus GN=Afg3l2 PE=1 SV=1 Q9CQR2 1 1 78,77 5,56E-01 326673,34 507363,14 515507,92 293501,09 252719,72 396014,19 757842,17 349938,75 221996,60 Iron-sulfur cluster co-chaperone protein HscB, mitochondrial OS=Mus musculus GN=Hscb PE=1 SV=2 Q9JK81 1 1 62,02 5,57E-01 12516,49 12847,54 18475,07 0,00 28461,45 21653,48 16296,60 25664,01 32936,36 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 Q9EPJ9 1 1 21,62 5,60E-01 27788,57 15611,23 13500,04 18496,82 20780,60 53863,75 8191,30 0,00 23140,97 RNA-binding protein with multiple splicing OS=Mus musculus GN=Rbpms PE=1 SV=2 Q3TBD2 2 1 59,78 5,61E-01 319861,24 739521,50 439226,34 348047,36 297298,32 373516,47 500555,93 474776,00 332273,30 Proteasome subunit beta type-7 OS=Mus musculus GN=Psmb7 PE=1 SV=1 Q78YZ6 1 1 26,88 5,67E-01 16680,36 20017,21 17189,83 15359,05 13953,92 9877,89 7898,61 22648,71 16871,21 Synaptojanin-2-binding protein OS=Mus musculus GN=Synj2bp PE=1 SV=1 Q6RUT7 1 1 75,18 5,68E-01 118847,34 217357,75 91924,70 115399,83 161286,33 83496,26 124916,53 165645,14 87444,35 Mitochondrial import inner membrane translocase subunit Tim10 OS=Mus musculus GN=Timm10 PE=1 SV=1 Q9EQI8 1 1 23,79 5,68E-01 3755,12 7614,62 25957,69 19405,69 18343,18 12271,53 14333,83 8684,54 13713,05 Nebulette OS=Mus musculus GN=Nebl PE=1 SV=1 P62245 1 1 22,10 5,69E-01 188764,81 57808,14 157116,70 153084,69 207904,85 198302,13 237161,86 82962,23 217126,25 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Mus musculus GN=Rpn1 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q6NSR8 2 1 109,87 5,70E-01 34074,24 43874,48 56940,10 92173,53 52921,94 45910,82 31386,39 49046,09 68479,14 Nucleoside diphosphate kinase 3 OS=Mus musculus GN=Nme3 PE=1 SV=3 Q9CQU0 1 1 28,74 5,71E-01 19319,62 97060,14 79079,70 91508,40 94089,73 116672,49 26673,95 79376,74 159503,93 Obscurin OS=Mus musculus GN=Obscn PE=1 SV=2 Q5SSK3 1 1 47,37 5,71E-01 46344,82 174560,01 40148,89 143372,36 117240,34 219697,16 407072,24 255895,09 87513,18 Fumarylacetoacetase OS=Mus musculus GN=Fah PE=1 SV=2 Q91WK2 1 1 103,34 5,72E-01 167163,73 155064,29 31726,28 153190,27 138457,94 194891,63 115628,49 114250,11 113775,33 Eukaryotic translation initiation factor 4E type 3 OS=Mus musculus GN=Eif4e3 PE=1 SV=1 P62320 1 1 33,76 5,73E-01 58701,09 46167,63 34741,51 31600,52 37198,70 49001,24 34732,73 51632,85 24805,20 Protein OS-9 OS=Mus musculus GN=Os9 PE=1 SV=2 P02535 2 1 57,34 5,73E-01 20876,69 115293,58 37461,60 68738,19 32515,26 29827,30 167053,60 127221,94 42214,91 Cathepsin Z OS=Mus musculus GN=Ctsz PE=1 SV=1 Q8BHJ7 1 1 21,99 5,75E-01 24621,12 67047,68 60654,32 44453,98 90199,73 113937,02 32155,61 47001,90 73676,28 Aquaporin-1 OS=Mus musculus GN=Aqp1 PE=1 SV=3 Q9QYI5 2 1 94,19 5,76E-01 13041,74 5591,62 21522,62 23282,22 9142,32 45739,33 12235,32 29940,97 24384,93 Cysteine-rich protein 2 OS=Mus musculus GN=Crip2 PE=1 SV=1 Q99M04 1 1 44,04 5,76E-01 22328,24 67329,03 24328,86 26876,68 20220,00 19959,05 30803,81 14659,07 30047,65 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Mus musculus GN=Ndufa11 PE=1 SV=2 Q9JLV6 1 1 31,62 5,77E-01 355720,31 427108,80 334426,58 287125,12 244528,99 283556,61 337694,17 350010,08 178413,81 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Mus musculus GN=Oxsm PE=1 SV=1 Q9WUA2 1 1 23,94 5,81E-01 45929,20 48486,18 46305,55 49843,00 46650,71 61426,87 46832,99 38752,26 31257,21 AMP deaminase 3 OS=Mus musculus GN=Ampd3 PE=1 SV=2 Q9CQ40 2 1 114,83 5,82E-01 28668,14 22693,82 38732,87 37654,58 43024,16 24105,94 23118,49 17760,14 42993,39 S-methyl-5'-thioadenosine phosphorylase OS=Mus musculus GN=Mtap PE=1 SV=1 Q62283 1 1 91,02 5,83E-01 26127,36 15231,50 50764,34 7638,37 32848,07 29446,34 45738,50 20099,04 30672,79 RNA helicase Ddx39b OS=Mus musculus GN=Ddx39b PE=1 SV=1 Q60770 2 1 89,20 5,83E-01 19452,47 0,00 12578,27 3778,32 2561,28 15548,60 10383,38 12352,88 3280,34 Spermidine synthase OS=Mus musculus GN=Srm PE=1 SV=1 Q9JIQ3 1 1 134,83 5,87E-01 35658,55 152236,41 123299,60 118402,96 124545,53 144975,47 108050,95 106699,97 81189,77 LIM and SH3 domain protein 1 OS=Mus musculus GN=Lasp1 PE=1 SV=1 P21126 1 1 21,09 5,89E-01 37469,29 0,00 23966,93 23443,88 8770,23 32587,56 15836,75 23885,43 34575,44 Apolipoprotein A-II OS=Mus musculus GN=Apoa2 PE=1 SV=2 Q91XV3 1 1 32,69 5,94E-01 7189,83 7046,60 11298,67 814,28 4783,03 5465,37 3759,30 10143,55 4150,06 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Mus musculus GN=Ndufa5 PE=1 SV=3 P02802 1 1 72,17 5,95E-01 218692,59 184025,29 44499,33 391430,70 140012,04 201832,47 152603,97 144448,34 202266,29 ATP synthase subunit delta, mitochondrial OS=Mus musculus GN=Atp5d PE=1 SV=1 Q8BIJ7 1 1 41,92 5,96E-01 13015,95 6489,97 10920,10 10992,79 13422,17 11574,16 6601,23 0,02 13970,62 OCIA domain-containing protein 1 OS=Mus musculus GN=Ociad1 PE=1 SV=1 P97822 1 1 49,68 6,00E-01 2961,95 29358,45 11677,92 5979,19 31455,17 8571,86 12852,44 18352,36 48324,78 Sorbin and SH3 domain-containing protein 2 OS=Mus musculus GN=Sorbs2 PE=1 SV=2 Q9JHU9 1 1 28,77 6,02E-01 30555,13 53180,22 221617,60 150192,79 118727,93 145685,02 32628,86 96161,14 104496,91 Aldose reductase-related protein 2 OS=Mus musculus GN=Akr1b8 PE=1 SV=2 P55284 1 1 24,99 6,03E-01 39877,40 75365,43 54327,02 57944,59 97893,03 77251,25 43862,71 54595,49 83704,95 Small muscular protein OS=Mus musculus GN=Smpx PE=1 SV=2 Q03249 1 1 48,08 6,05E-01 377464,78 350299,66 303410,86 478899,42 414155,32 382310,49 337771,74 275051,29 529634,45 60S ribosomal protein L22 OS=Mus musculus GN=Rpl22 PE=1 SV=2 P43025 1 1 43,84 6,05E-01 33249,92 4391,00 12725,02 15957,19 9145,57 0,82 0,00 4810,28 11115,52 Clustered mitochondria protein homolog OS=Mus musculus GN=Cluh PE=1 SV=2 Q9Z2Q5 1 1 42,87 6,09E-01 121306,38 148131,95 226416,09 164627,81 251596,89 221505,94 102514,21 152122,43 163689,75 Pleckstrin OS=Mus musculus GN=Plek PE=1 SV=1 Q8BPB0 1 1 66,20 6,09E-01 57579,59 134,65 40265,56 38740,23 32055,49 51631,33 2015,68 15811,72 45171,85 40S ribosomal protein S16 OS=Mus musculus GN=Rps16 PE=1 SV=4 Q3U276 1 1 75,04 6,13E-01 157496,17 215,13 94044,23 90011,63 88686,55 92263,92 43854,45 44155,34 95797,05 Translational activator of cytochrome c oxidase 1 OS=Mus musculus GN=Taco1 PE=1 SV=1 P51410 1 1 24,26 6,14E-01 11581,03 456,15 17759,91 13114,55 13250,58 15160,64 1455,85 12361,10 9251,66 Hexokinase-1 OS=Mus musculus GN=Hk1 PE=1 SV=3 Q8R2H9 1 1 52,82 6,14E-01 46718,99 42516,77 19337,19 35748,80 23491,17 19541,89 21009,00 18362,74 38588,95 Proteasome-associated protein ECM29 homolog OS=Mus musculus GN=Ecm29 PE=1 SV=3 O09117 1 1 51,86 6,15E-01 177508,67 247619,35 201353,36 177483,62 211122,03 382484,98 255765,34 444847,17 180639,64 Protein CDV3 OS=Mus musculus GN=Cdv3 PE=1 SV=2 Q9DBG9 1 1 91,71 6,18E-01 158838,55 145215,76 125640,31 121937,11 153945,41 114859,51 164586,63 135685,25 148569,17 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Mus musculus GN=Ndufa7 PE=1 SV=3 P06339;P01897;P144322 1 74,23 6,19E-01 18186,17 18865,68 30541,75 28986,17 17033,95 65640,59 34405,50 26147,10 23865,87 OS=Mus musculus GN=Rps8 PE=1 SV=2 P19253 1 1 40,96 6,21E-01 158161,31 126103,39 204867,78 201397,34 206512,61 170812,06 242407,90 278045,49 122281,68 Ethanolamine-phosphate cytidylyltransferase OS=Mus musculus GN=Pcyt2 PE=1 SV=1 P63168 3 1 212,29 6,22E-01 34092,32 48554,74 42090,33 48931,20 33857,69 38775,60 52349,29 36074,56 37858,59 Ubiquitin-associated protein 2-like OS=Mus musculus GN=Ubap2l PE=1 SV=1 Q5F285 2 1 106,97 6,22E-01 292904,84 296592,85 540696,75 389221,30 552130,18 614234,30 415458,59 454155,17 477270,47 Fructosamine-3-kinase OS=Mus musculus GN=Fn3k PE=1 SV=1 O35732 1 1 31,61 6,23E-01 1000923,35 1579093,30 1263171,84 1034703,37 1212154,40 1228396,72 1489245,70 1246024,14 1165614,06 Phosphatidate cytidylyltransferase 2 OS=Mus musculus GN=Cds2 PE=1 SV=1 Q8K2Y7 2 1 64,67 6,24E-01 33902,50 31639,49 24504,75 27341,80 33434,53 16479,67 17254,56 12503,75 35167,24 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 O89023 1 1 36,72 6,26E-01 62038,99 86333,79 104931,32 116617,73 68945,37 61760,47 69167,35 82492,51 85324,46 Probable glutamate--tRNA ligase, mitochondrial OS=Mus musculus GN=Ears2 PE=1 SV=1 P20065 1 1 57,76 6,26E-01 732,50 714,23 470,34 3340,08 0,00 2748,09 96,13 0,00 2962,48 WW domain-binding protein 2 OS=Mus musculus GN=Wbp2 PE=1 SV=1 Q3UV17 2 1 68,02 6,28E-01 94991,51 68714,65 87630,20 111236,65 13572,15 97378,47 186473,30 129881,88 46261,21 26S protease regulatory subunit 4 OS=Mus musculus GN=Psmc1 PE=1 SV=1 Q9DBL7 1 1 72,36 6,31E-01 15848,86 49854,34 2109,67 51025,67 15095,27 30134,91 16840,94 16176,06 28729,05 -III OS=Mus musculus GN=Serpinc1 PE=1 SV=1 P17879 6 1 402,75 6,32E-01 15922,59 2359,44 5050,77 17436,33 3409,05 5584,14 7526,76 1231,39 5202,84 Signal transducer and activator of transcription 3 OS=Mus musculus GN=Stat3 PE=1 SV=2 Q8BHG2 1 1 36,73 6,38E-01 11313,42 3508,74 4763,15 6471,64 12417,98 9090,50 2513,14 8973,23 10700,39 NADH-ubiquinone oxidoreductase chain 3 OS=Mus musculus GN=Mtnd3 PE=1 SV=3 Q8BXN7 1 1 25,58 6,38E-01 15287,21 7910,27 20551,25 8798,96 7986,42 14766,88 9116,63 20484,04 7702,20 Hydroxyacid-oxoacid transhydrogenase, mitochondrial OS=Mus musculus GN=Adhfe1 PE=1 SV=2 Q99LB6 1 1 26,57 6,39E-01 12212,18 11276,62 41381,17 31690,53 22215,30 30126,53 11778,18 19134,02 26278,16 Glutathione S-transferase Mu 2 OS=Mus musculus GN=Gstm2 PE=1 SV=2 Q8K003 1 1 29,85 6,40E-01 331476,70 237524,36 297641,40 342424,21 407196,91 251864,05 431435,96 477580,52 242006,69 Protein Jumonji OS=Mus musculus GN=Jarid2 PE=1 SV=1 Q9D7A8 1 1 30,64 6,43E-01 256682,39 255093,02 125752,71 181229,39 127415,37 164435,93 162814,17 199679,63 136029,12 CLIP-associating protein 1 OS=Mus musculus GN=Clasp1 PE=1 SV=2 Q99N95 1 1 37,03 6,44E-01 46232,65 36978,08 22827,44 32309,03 60746,10 29614,29 23142,65 27196,91 41558,95 Adenylyl cyclase-associated protein 2 OS=Mus musculus GN=Cap2 PE=1 SV=1 P32037 1 1 51,17 6,46E-01 7424,42 8986,21 0,00 945,50 4297,93 10381,68 12963,15 11770,94 0,00 Ras-related protein Rab-2A OS=Mus musculus GN=Rab2a PE=1 SV=1 A6PWV3 2 1 53,81 6,50E-01 34076,00 54625,75 44396,32 39212,63 37484,06 40289,09 94357,92 57243,51 37879,45 Glutathione S-transferase Mu 5 OS=Mus musculus GN=Gstm5 PE=1 SV=1 P24547 1 1 52,11 6,51E-01 20639,10 26238,90 8955,83 11546,54 11813,21 13039,21 24890,34 18089,97 14836,03 OS=Mus musculus GN=Anxa6 PE=1 SV=3 Q8K273 1 1 38,39 6,53E-01 18638,12 9360,86 15490,61 11081,11 16293,82 20123,32 12021,96 23754,47 4858,82 ProSAAS OS=Mus musculus GN=Pcsk1n PE=1 SV=2 Q5ND29 3 1 107,96 6,54E-01 5862,31 0,00 10352,67 15321,60 12994,04 21115,35 0,00 6772,04 24940,24 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial OS=Mus musculus GN=Ndufb2 PE=1 SV=1 Q8R2Y8 1 1 52,94 6,54E-01 217385,03 160233,79 88582,23 133264,87 154717,56 177335,06 243117,72 159272,62 107123,93 CD99 antigen OS=Mus musculus GN=Cd99 PE=1 SV=1 P39039 1 1 38,32 6,57E-01 50380,40 0,00 39795,27 16051,31 0,00 17357,18 41549,87 41,14 13073,10 Ig kappa chain V-III region ABPC 22/PC 9245 OS=Mus musculus PE=1 SV=1 Q9Z210 2 1 65,75 6,58E-01 2403,94 48,77 10974,66 2340,03 0,00 11331,90 95,47 23575,51 3492,44 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Mus musculus GN=Chchd2 PE=2 SV=1 P08207 2 1 81,59 6,63E-01 94847,05 187501,69 106184,58 151432,19 171613,40 158612,53 119008,89 116559,49 222098,56 Hydroxyacylglutathione hydrolase, mitochondrial OS=Mus musculus GN=Hagh PE=1 SV=2 P28352 1 1 69,04 6,64E-01 46671,94 8372,98 73709,77 67805,12 51925,86 64637,96 44252,01 434,84 91265,88 Prefoldin subunit 5 OS=Mus musculus GN=Pfdn5 PE=1 SV=1 Q9D0L7 1 1 58,78 6,66E-01 3662,60 0,00 6674,50 0,00 2814,47 10758,65 5666,01 3967,14 14423,89 40S ribosomal protein S20 OS=Mus musculus GN=Rps20 PE=1 SV=1 Q8CFV9 1 1 38,96 6,66E-01 31636,48 36964,41 7579,73 40508,72 56236,23 34920,93 38498,09 88013,12 41060,48 60S ribosomal protein L10a OS=Mus musculus GN=Rpl10a PE=1 SV=3 P01654 2 1 150,31 6,75E-01 134011,64 23871,10 26300,62 57671,06 21635,80 5454,15 69778,72 4145,36 7288,45 Prelamin-A/C OS=Mus musculus GN=Lmna PE=1 SV=2 Q9D7S9 1 1 37,20 6,76E-01 50262,05 12954,85 5600,17 34267,10 0,00 23469,72 0,00 8187,75 7980,62 Coiled-coil domain-containing protein 90B, mitochondrial OS=Mus musculus GN=Ccdc90b PE=1 SV=1 Q8BWA5 1 1 48,58 6,77E-01 11217,45 0,00 16782,78 8273,95 28288,13 17788,06 5423,56 0,00 13991,16 Glutaredoxin-1 OS=Mus musculus GN=Glrx PE=1 SV=3 Q7TSL0 2 1 52,41 6,81E-01 7222840,33 589344,53 7631546,88 5043691,84 5320286,79 5243816,85 3624549,72 6785778,42 7241004,61 OS=Mus musculus GN=Galk1 PE=1 SV=2 Q501J6 4 1 143,20 6,84E-01 14126,79 18295,63 19419,47 17690,01 17698,04 16150,04 19016,59 17428,73 17763,91 COP9 signalosome complex subunit 5 OS=Mus musculus GN=Cops5 PE=1 SV=3 Q9QYS9 1 1 41,96 6,85E-01 40796,94 79661,94 62592,15 67449,34 88602,82 72326,96 32057,97 60272,09 135977,03 Vacuolar protein sorting-associated protein 26B OS=Mus musculus GN=Vps26b PE=1 SV=1 Q0VE82 3 1 81,94 6,86E-01 14353,08 3433,32 25218,94 14484,03 30759,54 35926,88 0,00 19803,75 25248,94 Inositol monophosphatase 1 OS=Mus musculus GN=Impa1 PE=1 SV=1 Q91WQ3 3 1 119,95 6,86E-01 150573,76 127126,95 454333,40 634217,20 243711,83 421624,98 75329,26 386918,89 583707,29 Carbonyl reductase family member 4 OS=Mus musculus GN=Cbr4 PE=1 SV=2 Q80SZ7 2 1 66,16 6,97E-01 234074,06 130879,37 89202,54 115696,95 157384,66 116139,59 155372,36 139513,31 205924,98 FAS-associated death domain protein OS=Mus musculus GN=Fadd PE=1 SV=1 Q91ZX7 1 1 90,41 6,99E-01 2110,70 0,00 6063,85 3883,30 14258,17 8161,95 0,00 2312,54 10524,22 -1 heavy chain OS=Mus musculus GN=Kif5b PE=1 SV=3 Q64337 1 1 31,71 7,02E-01 6754,76 14562,69 16792,57 41600,87 12871,82 6780,55 0,00 29525,33 14788,76 Calponin-2 OS=Mus musculus GN=Cnn2 PE=1 SV=1 O35685 3 1 110,17 7,03E-01 119452,12 175387,59 170066,65 162534,12 150171,46 152978,28 108082,44 153937,36 167338,39 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus GN=Pdha1 PE=1 SV=1 Q9CQZ1 1 1 40,04 7,05E-01 19401,49 140615,28 80709,34 59070,79 46728,44 48514,28 89729,16 73973,30 72447,13 Transcription factor A, mitochondrial OS=Mus musculus GN=Tfam PE=1 SV=2 Q9ERP3 3 1 175,78 7,11E-01 56416,30 60539,97 62069,09 47006,91 85321,10 77370,38 33521,28 39350,35 56562,14 Keratin, type II cytoskeletal 5 OS=Mus musculus GN=Krt5 PE=1 SV=1 Q78JW9 1 1 28,80 7,15E-01 3061,75 10679,15 17307,35 26343,67 3603,70 9909,77 10263,56 12996,75 14972,21 Dihydrolipoyl dehydrogenase, mitochondrial OS=Mus musculus GN=Dld PE=1 SV=2 Q8VED5 2 1 65,34 7,19E-01 9815,35 33897,75 29795,73 40082,93 19047,92 51603,59 31913,89 45906,12 34900,67 Transmembrane protein 33 OS=Mus musculus GN=Tmem33 PE=1 SV=1 Q5DTN8 1 1 24,59 7,21E-01 105838,67 131767,66 89228,32 71472,84 91841,30 129731,96 104465,73 87937,74 94923,68 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Mus musculus GN=Gcat PE=1 SV=2 Q99N87 1 1 37,31 7,25E-01 14487,38 20431,77 43785,61 22357,88 14941,03 19064,92 33567,19 74330,26 14546,69 Putative Polycomb group protein ASXL1 OS=Mus musculus GN=Asxl1 PE=1 SV=1 Q80UU9 2 1 183,10 7,25E-01 1418,71 30101,99 974,05 5322,88 14375,56 5798,85 1346,47 16360,17 14526,95 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Ivd PE=1 SV=1 P28076 1 1 35,14 7,29E-01 17785,48 22990,59 16304,73 32059,41 16179,86 41163,21 37605,86 4347,90 29934,22 Glutathione S-transferase A3 OS=Mus musculus GN=Gsta3 PE=1 SV=2 Q64213 1 1 30,99 7,30E-01 41350,32 10819,16 24971,93 24990,60 27694,45 27331,27 25710,96 23077,62 59174,54 Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Mus musculus GN=Pcca PE=1 SV=2 Q923B6 1 1 35,72 7,33E-01 36176,75 7437,27 34291,70 31097,74 28981,61 35428,11 31170,23 33259,67 32257,31 Mitochondrial intermediate peptidase OS=Mus musculus GN=Mipep PE=1 SV=1 Q9CQF6 1 1 83,59 7,37E-01 5838,52 2755,12 7241,54 3018,08 2309,90 5321,94 6483,11 12329,55 2311,31 Aspartate aminotransferase, cytoplasmic OS=Mus musculus GN=Got1 PE=1 SV=3 Q80YC5 1 1 26,03 7,38E-01 10482,56 0,00 6792,63 6194,44 0,00 4836,76 15655,00 0,00 9258,24 Mitochondrial import inner membrane translocase subunit TIM16 OS=Mus musculus GN=Pam16 PE=1 SV=1 Q922C1 1 1 25,35 7,38E-01 40648,82 125012,23 472064,73 216755,58 244328,47 305540,12 93391,38 228590,60 345676,04 Creatine kinase M-type OS=Mus musculus GN=Ckm PE=1 SV=1 P04925 1 1 21,56 7,39E-01 48554,64 33120,07 34947,82 49626,63 32040,84 54987,64 60516,85 38881,91 30860,04 Phosphoglucomutase-1 OS=Mus musculus GN=Pgm1 PE=1 SV=4 Q8R143 1 1 22,84 7,41E-01 0,00 4384,44 1315,18 1653,89 978,18 4705,82 0,00 0,00 6557,07 Palmitoyl-protein thioesterase 1 OS=Mus musculus GN=Ppt1 PE=1 SV=2 P10833 4 1 179,83 7,51E-01 10162,87 9576,65 16809,42 13567,96 11546,22 16339,23 12514,74 17203,36 15650,31 40S ribosomal protein S3a OS=Mus musculus GN=Rps3a PE=1 SV=3 O54931 2 1 147,19 7,53E-01 35792,89 29702,60 60320,09 33828,04 50174,17 33234,88 44954,27 30477,46 33272,29 ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Mus musculus GN=Clpp PE=1 SV=1 Q9D6Z0 1 1 35,71 7,55E-01 0,00 0,00 6344,12 0,00 0,00 7853,68 309,63 3440,48 0,00 Elongation factor 2 OS=Mus musculus GN=Eef2 PE=1 SV=2 P97449 2 1 125,63 7,76E-01 16997,24 40641,23 38124,26 44480,97 32356,04 41659,57 22877,39 12096,36 55897,61 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=1 SV=3 Q922D4 1 1 66,13 7,81E-01 21621,59 73856,61 24972,65 34422,64 27987,56 25052,20 30989,20 23378,22 52129,87 Protein phosphatase 1 regulatory subunit 3A OS=Mus musculus GN=Ppp1r3a PE=1 SV=2 Q6PGB6 1 1 51,18 7,84E-01 5480,02 4226,37 4630,21 4407,13 5339,92 4415,68 4308,21 5441,09 5461,55 BolA-like protein 3 OS=Mus musculus GN=Bola3 PE=1 SV=1 Q61166 1 1 26,78 7,84E-01 46552,23 36360,20 36710,28 50944,12 44336,18 29721,43 36865,62 76501,82 55780,44 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 P08030 2 1 60,37 7,85E-01 420593,92 337932,35 220124,22 257070,41 389047,84 340007,15 254482,13 195808,34 486482,92 Amine oxidase [flavin-containing] B OS=Mus musculus GN=Maob PE=1 SV=4 Q99N50 2 1 53,89 7,86E-01 26324,06 133012,60 120214,36 84955,56 199475,05 60799,96 74439,89 183731,06 107873,35 Myotilin OS=Mus musculus GN=Myot PE=1 SV=1 A6H6E2 1 1 41,60 7,87E-01 26,79 2853,76 2486,60 3910,63 4742,58 3733,60 0,00 3002,96 6750,66 Dihydropyrimidinase-related protein 2 OS=Mus musculus GN=Dpysl2 PE=1 SV=2 P20444 1 1 28,36 7,87E-01 33389,13 21188,26 7604,73 16694,27 21610,71 19641,78 23615,42 11617,12 13947,00 DCC-interacting protein 13-alpha OS=Mus musculus GN=Appl1 PE=1 SV=1 Q8BXZ1 1 1 74,43 7,88E-01 27913,23 19230,14 57378,88 27973,42 41743,88 35797,71 44488,10 70967,62 12490,48 Tubulin beta-5 chain OS=Mus musculus GN=Tubb5 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q8BKS9 1 1 32,86 7,91E-01 218381,88 494903,83 194141,37 266903,26 315463,78 216547,06 212507,38 584559,57 211668,47 Mitochondrial glutamate carrier 2 OS=Mus musculus GN=Slc25a18 PE=1 SV=4 Q4G0F8 3 1 66,44 7,92E-01 5803,13 3803,31 4246,57 4145,35 4702,05 4832,52 3539,27 6312,89 5304,59 Ig gamma-2A chain C region, A allele OS=Mus musculus GN=Ighg PE=1 SV=1 P68134 25 1 2049,89 7,93E-01 122808,48 117245,93 106260,69 69428,79 104648,26 78480,12 170453,50 163715,63 50928,84 -specific heparan sulfate proteoglycan core protein OS=Mus musculus GN=Hspg2 PE=1 SV=1 Q8VDP4 1 1 30,39 7,94E-01 262908,62 150495,14 217134,39 132916,24 219791,57 146695,22 319144,03 145247,54 136011,08 60S ribosomal protein L15 OS=Mus musculus GN=Rpl15 PE=2 SV=4 Q9CPW2 1 1 48,33 8,06E-01 26766,08 26946,90 20172,59 32166,36 29405,69 22420,13 23854,06 9779,36 33281,88 ATP synthase subunit alpha, mitochondrial OS=Mus musculus GN=Atp5a1 PE=1 SV=1 Q8K1N1 1 1 34,73 8,07E-01 9474,67 5309,71 1587,40 6802,09 5688,84 3703,11 0,00 10016,35 10501,15 Traf2 and NCK-interacting protein kinase OS=Mus musculus GN=Tnik PE=1 SV=2 Q8K558 1 1 84,90 8,09E-01 34899,87 39341,39 3095,73 3196,49 9801,06 73114,16 49005,24 29967,70 239,04 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Mus musculus GN=Ndufs1 PE=1 SV=2 O09164 1 1 37,47 8,12E-01 12535,71 3446,49 8746,26 5907,21 5992,72 4365,15 14033,21 8658,55 5332,67 Carnitine O-palmitoyltransferase 1, liver isoform OS=Mus musculus GN=Cpt1a PE=1 SV=4 Q3V1L4 3 1 112,09 8,14E-01 37846,03 69877,23 46557,68 52128,85 40573,93 56823,33 30837,71 65248,40 60349,82 , mitochondrial OS=Mus musculus GN=Dguok PE=1 SV=3 Q9DBB5 1 1 31,90 8,28E-01 12176,52 11622,98 30205,52 32332,86 22697,11 29422,53 13421,07 39578,57 27742,93 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Mus musculus GN=Tab1 PE=1 SV=2 Q8K2C7 3 1 83,91 8,28E-01 4742774,49 5773139,04 3989573,11 4737773,59 4751950,43 4112993,12 3403111,60 4862446,73 4951163,44 OS=Mus musculus GN=Anxa7 PE=1 SV=2 Q9WUU7 1 1 26,22 8,28E-01 59463,50 3159,99 62340,98 34875,70 41308,71 38958,69 8825,29 22710,95 38072,49 T-complex protein 1 subunit zeta OS=Mus musculus GN=Cct6a PE=1 SV=3 O08739 1 1 85,32 8,31E-01 12822,58 27989,34 31896,38 35834,36 24380,44 29453,15 41128,74 20490,55 17201,46 39S ribosomal protein L12, mitochondrial OS=Mus musculus GN=Mrpl12 PE=1 SV=2 Q64674 1 1 24,70 8,34E-01 16289,27 2540,87 1258,22 4560,15 6758,25 5982,89 3373,28 2838,37 8143,41 Alcohol dehydrogenase 1 OS=Mus musculus GN=Adh1 PE=1 SV=2 Q61792 1 1 22,32 8,37E-01 3850,32 9637,35 13196,41 4666,55 6480,10 14334,54 31875,53 19971,04 2879,07 40S ribosomal protein S18 OS=Mus musculus GN=Rps18 PE=1 SV=3 P67984 1 1 26,87 8,48E-01 176607,10 160268,26 142703,36 132426,43 166281,28 291971,98 248254,00 260139,96 113466,83 Beta-parvin OS=Mus musculus GN=Parvb PE=1 SV=1 P14131 1 1 54,06 8,53E-01 204428,75 223068,24 201486,10 174657,61 225894,69 149047,62 430069,05 150667,29 128669,23 Osteoclast-stimulating factor 1 OS=Mus musculus GN=Ostf1 PE=1 SV=2 Q922E4 1 1 32,37 8,59E-01 57619,00 67712,58 98122,41 91704,51 114826,31 53795,36 76102,32 36056,16 136531,93 Intersectin-1 OS=Mus musculus GN=Itsn1 PE=1 SV=2 Q9EPU0 1 1 31,30 8,63E-01 0,00 0,00 5794,87 23580,45 1897,40 0,00 0,00 0,00 2385,24 Transgelin OS=Mus musculus GN=Tagln PE=1 SV=3 Q9CXJ1 1 1 40,87 8,63E-01 18820,78 23764,02 22293,63 28576,94 19121,48 18640,21 18139,16 17179,95 21815,91 Phosphopantothenate--cysteine ligase OS=Mus musculus GN=Ppcs PE=1 SV=1 P03899 1 1 93,25 8,66E-01 3932773,35 3717756,31 3851450,09 2858001,24 2805714,97 4261168,82 5930187,31 3061871,10 2541677,18 Histamine N-methyltransferase OS=Mus musculus GN=Hnmt PE=1 SV=1 Q62315 2 1 49,80 8,70E-01 489907,00 871802,69 929276,04 585966,66 864376,09 626569,09 614230,78 708280,50 878460,32 Superoxide dismutase [Mn], mitochondrial OS=Mus musculus GN=Sod2 PE=1 SV=3 Q80TV8 1 1 83,83 8,71E-01 4595,89 5016,48 6038,43 4059,92 3694,68 8053,11 5760,47 6936,17 3220,97 Eukaryotic translation initiation factor 1A, X-chromosomal OS=Mus musculus GN=Eif1ax PE=2 SV=3 Q9QXV0 1 1 66,45 8,80E-01 1774,80 4521,07 7702,38 3013,00 4941,48 5895,69 7705,10 6598,62 3927,01 DDB1- and CUL4-associated factor 8 OS=Mus musculus GN=Dcaf8 PE=1 SV=1 Q8VCN6 1 1 57,51 8,83E-01 276776,81 250186,92 232725,23 231730,77 268244,91 336278,23 453817,47 404259,96 332186,33 Talin-2 OS=Mus musculus GN=Tln2 PE=1 SV=3 P01662 2 1 175,09 8,84E-01 0,20 4478,39 4495,59 71880,31 0,00 9432,08 0,00 3754,74 5317,85 T-complex protein 11-like protein 2 OS=Mus musculus GN=Tcp11l2 PE=1 SV=1 P60867 1 1 26,18 8,92E-01 697067,61 528404,86 826273,14 425332,41 582616,81 748552,50 645888,56 895061,10 404527,92 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Mus musculus GN=Gnb2l1 PE=1 SV=3 P53026 1 1 24,86 8,93E-01 574345,36 411812,05 14546,25 371145,91 92157,61 143451,79 348526,83 200193,63 136396,41 Kynurenine--oxoglutarate transaminase 3 OS=Mus musculus GN=Ccbl2 PE=1 SV=1 P48678 1 1 52,42 8,94E-01 4769,42 12283,92 3315,14 10049,26 10357,39 11157,33 5625,30 15331,31 9491,53 Stress-70 protein, mitochondrial OS=Mus musculus GN=Hspa9 PE=1 SV=3 Q9R0N0 1 1 54,51 8,96E-01 110221,93 99385,04 152199,99 113539,60 109739,00 111330,91 65058,81 129244,81 109999,07 Nicotinate phosphoribosyltransferase OS=Mus musculus GN=Naprt PE=1 SV=1 Q08093 3 1 212,34 9,00E-01 74527,10 37297,97 26961,02 35753,77 29727,59 63893,89 66174,30 45517,17 28110,82 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Mus musculus GN=Ndufa10 PE=1 SV=1 Q922U2 3 1 117,94 9,02E-01 80287,51 104809,82 99592,76 154086,91 33516,70 167612,94 129976,61 107940,72 84348,50 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform OS=Mus musculus GN=Myl2 PE=1 SV=3 Q9CR67 1 1 40,98 9,06E-01 21136,59 102565,83 73021,08 59734,43 37358,92 67829,93 65301,41 78998,37 37860,43 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 OS=Mus musculus GN=Ndufb7 PE=1 SV=3 P59598 2 1 65,18 9,07E-01 0,00 21709,04 25166,18 6839,24 5877,50 0,00 0,00 0,00 10388,69 Homeobox protein Nkx-6.1 OS=Mus musculus GN=Nkx6-1 PE=1 SV=1 Q6P7W0 1 1 33,30 9,26E-01 791373,20 936833,16 580287,13 758947,70 822594,61 460620,05 656098,94 531995,51 888569,73 26S protease regulatory subunit 7 OS=Mus musculus GN=Psmc2 PE=1 SV=5 Q9DB41 2 1 53,42 9,39E-01 6393,09 10682,48 11969,91 11935,98 9640,14 10135,27 8161,90 8026,12 12097,84 von Willebrand factor A domain-containing protein 5A OS=Mus musculus GN=Vwa5a PE=1 SV=2 P83510;P97820 4 1 131,04 9,46E-01 200688,23 88117,75 101462,92 91460,95 121290,33 111023,26 149400,58 187727,78 65518,62 Pterin-4-alpha-carbinolamine dehydratase 2 OS=Mus musculus GN=Pcbd2 PE=1 SV=2 Q8CF89 1 1 31,35 9,48E-01 727382,91 747786,46 611801,66 561525,27 775188,88 744566,24 521878,82 754555,12 765271,58 Protein Mpv17 OS=Mus musculus GN=Mpv17 PE=1 SV=1 Q62422 1 1 63,18 9,55E-01 126533,57 92810,70 66564,74 65951,79 114382,00 93834,74 162509,79 43822,98 129460,55 Peroxisomal bifunctional enzyme OS=Mus musculus GN=Ehhadh PE=1 SV=4 Q9Z0R4 4 1 119,98 9,55E-01 25767,53 38958,56 63061,31 42323,24 42439,82 52431,50 56994,10 40696,17 35775,15 Alpha-1B-glycoprotein OS=Mus musculus GN=A1bg PE=1 SV=1 Q8VDG5 1 1 36,68 9,59E-01 83291,26 69448,65 62999,17 77273,50 40737,04 79087,47 37369,11 62575,52 95973,58 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Mus musculus GN=Coq3 PE=1 SV=1 Q91VF2 1 1 55,44 9,62E-01 0,00 10619,21 37420,12 14525,15 11277,39 0,00 0,00 42908,86 3204,26 Spectrin beta chain, non-erythrocytic 1 OS=Mus musculus GN=Sptbn1 PE=1 SV=2 Q8BMJ3 1 1 43,39 9,66E-01 94160,32 43967,62 48126,17 64293,47 54308,45 75212,54 79554,31 90803,51 62990,29 39S ribosomal protein L14, mitochondrial OS=Mus musculus GN=Mrpl14 PE=1 SV=1 Q8N7N5 1 1 41,00 9,66E-01 18735,39 16480,55 20873,35 22302,12 24891,11 16712,08 15793,84 28736,89 14930,62 Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Mus musculus GN=Naca PE=1 SV=2 Q8K1H7 2 1 50,23 9,67E-01 5631,54 8739,90 10022,89 6077,26 6762,74 10913,78 8975,49 10868,58 4727,71 LanC-like protein 2 OS=Mus musculus GN=Lancl2 PE=1 SV=1 Q99MA9 2 1 51,85 9,74E-01 61863,40 65150,94 65542,97 58863,94 66006,24 60946,93 114438,16 47724,15 51616,34 Histidine-rich glycoprotein OS=Mus musculus GN=Hrg PE=1 SV=2 Q9CZL5 2 1 54,90 9,78E-01 79929,65 80083,80 67507,82 96009,12 80746,91 64769,29 50727,06 77329,92 99804,84 2 OS=Mus musculus GN=Hmox2 PE=1 SV=1 Q9DBM2 1 1 37,01 9,83E-01 647,81 7855,03 17563,74 4754,26 6661,48 26517,51 0,00 350715,43 21035,68 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Mus musculus GN=Idh1 PE=1 SV=2 O70252 1 1 60,65 9,94E-01 136636,55 110169,75 190287,30 94110,94 167619,62 215312,86 116452,85 168056,15 168192,49 N-acetylgalactosamine kinase OS=Mus musculus GN=Galk2 PE=1 SV=1 Q68FH4 2 1 54,77 9,98E-01 28831,27 20685,56 29996,13 28599,17 25237,47 25188,36 12767,44 23935,32 43759,00 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Mus musculus GN=Rpn2 PE=1 SV=1 Q3THF9 1 1 30,01 1,00E+00 630782,49 848090,85 689395,00 751052,72 832518,94 575466,53 682920,55 760896,64 758445,00 Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Mus musculus GN=Coq10b PE=1 SV=1 A2A9C3 4 0 108,15 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 A2A432 1 0 30,68 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 A2A690 2 0 94,39 Protein TANC2 OS=Mus musculus GN=Tanc2 PE=1 SV=1 A2AG06 1 0 34,25 Uncharacterized protein C17orf104 homolog OS=Mus musculus GN=Gm1564 PE=2 SV=1 A2AGL3 11 0 387,37 Ryanodine receptor 3 OS=Mus musculus GN=Ryr3 PE=1 SV=1 A2ALW5 2 0 48,60 DnaJ homolog subfamily C member 25 OS=Mus musculus GN=Dnajc25 PE=1 SV=1 A2AQP0 13 0 462,87 Myosin-7B OS=Mus musculus GN=Myh7b PE=3 SV=1 A2AS55 1 0 40,48 Ankyrin repeat domain-containing protein 16 OS=Mus musculus GN=Ankrd16 PE=2 SV=1 B1AVY7 2 0 65,77 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 B2RSH2 4 0 155,97 Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Mus musculus GN=Gnai1 PE=1 SV=1 B2RVY9 1 0 21,72 Transmembrane protein 182 OS=Mus musculus GN=Tmem182 PE=1 SV=1 B2RWW0 2 0 51,92 T-cell activation Rho GTPase-activating protein OS=Mus musculus GN=Tagap PE=2 SV=2 B9EKR1 1 0 24,23 Receptor-type tyrosine-protein phosphatase zeta OS=Mus musculus GN=Ptprz1 PE=1 SV=1 E9PVD1 2 0 57,11 Coiled-coil domain-containing protein 62 OS=Mus musculus GN=Ccdc62 PE=3 SV=1 E9PZQ0 11 0 391,15 Ryanodine receptor 1 OS=Mus musculus GN=Ryr1 PE=1 SV=1 G3UYX5 2 0 52,76 Regulator of G-protein signaling 22 OS=Mus musculus GN=Rgs22 PE=1 SV=1 O08539 2 0 61,96 Myc box-dependent-interacting protein 1 OS=Mus musculus GN=Bin1 PE=1 SV=1 O08638 8 0 333,22 Myosin-11 OS=Mus musculus GN=Myh11 PE=1 SV=1 O08807 4 0 200,13 Peroxiredoxin-4 OS=Mus musculus GN=Prdx4 PE=1 SV=1 O35099 2 0 86,54 Mitogen-activated protein kinase kinase kinase 5 OS=Mus musculus GN=Map3k5 PE=1 SV=3 O35286 1 0 49,11 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Mus musculus GN=Dhx15 PE=1 SV=2 O35945 5 0 216,16 Aldehyde dehydrogenase, cytosolic 1 OS=Mus musculus GN=Aldh1a7 PE=1 SV=1 O55029 1 0 43,27 Coatomer subunit beta' OS=Mus musculus GN=Copb2 PE=1 SV=2 O55111 2 0 47,92 Desmoglein-2 OS=Mus musculus GN=Dsg2 PE=1 SV=3 O70472 1 0 20,69 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 O70579 1 0 35,71 Peroxisomal membrane protein PMP34 OS=Mus musculus GN=Slc25a17 PE=1 SV=1 O88444 2 0 63,25 Adenylate cyclase type 1 OS=Mus musculus GN=Adcy1 PE=1 SV=2 O88708 1 0 34,60 Origin recognition complex subunit 4 OS=Mus musculus GN=Orc4 PE=1 SV=2 O88974 1 0 45,43 Histone-lysine N-methyltransferase SETDB1 OS=Mus musculus GN=Setdb1 PE=1 SV=1 P0C605 2 0 57,86 cGMP-dependent protein kinase 1 OS=Mus musculus GN=Prkg1 PE=1 SV=1 P00186 1 0 20,32 Cytochrome P450 1A2 OS=Mus musculus GN=Cyp1a2 PE=1 SV=1 P01631 1 0 86,61 Ig kappa chain V-II region 26-10 OS=Mus musculus PE=1 SV=1 P01635 1 0 93,31 Ig kappa chain V-V region K2 (Fragment) OS=Mus musculus PE=1 SV=1 P01636 2 0 151,28 Ig kappa chain V-V region MOPC 149 OS=Mus musculus PE=1 SV=1 P01680 1 0 45,71 Ig kappa chain V-IV region S107B OS=Mus musculus PE=4 SV=1 P01831 1 0 36,30 Thy-1 membrane glycoprotein OS=Mus musculus GN=Thy1 PE=1 SV=1 P03893 1 0 66,99 NADH-ubiquinone oxidoreductase chain 2 OS=Mus musculus GN=Mtnd2 PE=1 SV=2 P05063 7 0 377,12 Fructose-bisphosphate OS=Mus musculus GN=Aldoc PE=1 SV=4 P05213 18 0 1202,70 Tubulin alpha-1B chain OS=Mus musculus GN=Tuba1b PE=1 SV=2 P05977 4 0 156,49 Myosin light chain 1/3, skeletal muscle isoform OS=Mus musculus GN=Myl1 PE=1 SV=2 P06795 1 0 34,85 Multidrug resistance protein 1B OS=Mus musculus GN=Abcb1b PE=1 SV=1 P08071 2 0 69,29 Lactotransferrin OS=Mus musculus GN=Ltf PE=1 SV=4 P12399 1 0 43,62 Protein CTLA-2-alpha OS=Mus musculus GN=Ctla2a PE=2 SV=2 P12658 2 0 64,63 OS=Mus musculus GN=Calb1 PE=1 SV=2 P12804 1 0 33,78 Fibroleukin OS=Mus musculus GN=Fgl2 PE=1 SV=1 P13541 25 0 1289,17 Myosin-3 OS=Mus musculus GN=Myh3 PE=2 SV=2 P13542 29 0 1852,80 Myosin-8 OS=Mus musculus GN=Myh8 PE=2 SV=2 P16374 1 0 34,87 Zinc finger protein 60 OS=Mus musculus GN=Zfp60 PE=2 SV=2

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

P16627 6 0 387,84 Heat shock 70 kDa protein 1-like OS=Mus musculus GN=Hspa1l PE=1 SV=4 P17156 12 0 845,39 Heat shock-related 70 kDa protein 2 OS=Mus musculus GN=Hspa2 PE=1 SV=2 P19639;O35660 11 0 592,62 Glutathione S-transferase Mu 3 OS=Mus musculus GN=Gstm3 PE=1 SV=2 P21107 18 0 996,31 Tropomyosin alpha-3 chain OS=Mus musculus GN=Tpm3 PE=1 SV=3 P21460 1 0 44,79 Cystatin-C OS=Mus musculus GN=Cst3 PE=1 SV=2 P27038 1 0 30,96 Activin receptor type-2A OS=Mus musculus GN=Acvr2a PE=1 SV=1 P28658 1 0 23,58 Ataxin-10 OS=Mus musculus GN=Atxn10 PE=1 SV=2 P28666 23 0 1063,34 Murinoglobulin-2 OS=Mus musculus GN=Mug2 PE=1 SV=2 P28738 5 0 226,04 Kinesin heavy chain isoform 5C OS=Mus musculus GN=Kif5c PE=1 SV=3 P31254 6 0 231,68 Ubiquitin-like modifier-activating enzyme 1 Y OS=Mus musculus GN=Uba1y PE=1 SV=2 P35123 2 0 60,41 Ubiquitin carboxyl-terminal hydrolase 4 OS=Mus musculus GN=Usp4 PE=1 SV=3 P35276;P63011;Q9CZT84 0 194,83 Ras-related protein Rab-3D OS=Mus musculus GN=Rab3d PE=1 SV=1 P35487 1 0 69,93 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Mus musculus GN=Pdha2 PE=1 SV=1 P40749 1 0 35,26 Synaptotagmin-4 OS=Mus musculus GN=Syt4 PE=1 SV=2 P46660 2 0 65,99 Alpha- OS=Mus musculus GN=Ina PE=1 SV=3 P48725 2 0 52,71 Pericentrin OS=Mus musculus GN=Pcnt PE=1 SV=2 P49813 1 0 40,78 -1 OS=Mus musculus GN=Tmod1 PE=1 SV=2 P52430 1 0 25,98 Serum paraoxonase/arylesterase 1 OS=Mus musculus GN=Pon1 PE=1 SV=2 P55258 5 0 185,94 Ras-related protein Rab-8A OS=Mus musculus GN=Rab8a PE=1 SV=2 P56203 2 0 57,71 Cathepsin W OS=Mus musculus GN=Ctsw PE=2 SV=2 P56213 1 0 69,52 FAD-linked sulfhydryl oxidase ALR OS=Mus musculus GN=Gfer PE=1 SV=2 P57780 7 0 371,46 Alpha-actinin-4 OS=Mus musculus GN=Actn4 PE=1 SV=1 P58774 13 0 862,52 Tropomyosin beta chain OS=Mus musculus GN=Tpm2 PE=1 SV=1 P59279 4 0 179,36 Ras-related protein Rab-2B OS=Mus musculus GN=Rab2b PE=1 SV=1 P62309 1 0 32,53 Small nuclear ribonucleoprotein G OS=Mus musculus GN=Snrpg PE=1 SV=1 P68373 17 0 1134,33 Tubulin alpha-1C chain OS=Mus musculus GN=Tuba1c PE=1 SV=1 P70196 1 0 31,55 TNF receptor-associated factor 6 OS=Mus musculus GN=Traf6 PE=1 SV=2 P70268 2 0 77,36 Serine/threonine-protein kinase N1 OS=Mus musculus GN=Pkn1 PE=1 SV=3 P97329 2 0 59,80 Kinesin-like protein KIF20A OS=Mus musculus GN=Kif20a PE=2 SV=1 P97384 2 0 108,31 OS=Mus musculus GN=Anxa11 PE=1 SV=2 Q0VBD2 1 0 34,25 Protein MCM10 homolog OS=Mus musculus GN=Mcm10 PE=1 SV=1 Q0VGY8 1 0 42,71 Protein TANC1 OS=Mus musculus GN=Tanc1 PE=1 SV=2 Q0ZCJ7 1 0 34,47 MEF2-activating motif and SAP domain-containing transcriptional regulator OS=Mus musculus GN=Mamstr PE=1 SV=2 Q3TDK6 2 0 54,36 Protein rogdi homolog OS=Mus musculus GN=Rogdi PE=1 SV=2 Q3THE2 2 0 134,28 Myosin regulatory light chain 12B OS=Mus musculus GN=Myl12b PE=1 SV=2 Q3TRJ4 1 0 26,93 Keratin, type I cytoskeletal 26 OS=Mus musculus GN=Krt26 PE=2 SV=1 Q3TTY5 1 0 65,95 Keratin, type II cytoskeletal 2 epidermal OS=Mus musculus GN=Krt2 PE=1 SV=1 Q3U6N9 1 0 42,48 UPF0488 protein C8orf33 homolog OS=Mus musculus PE=2 SV=1 Q3UGF1 1 0 46,63 WD repeat-containing protein 19 OS=Mus musculus GN=Wdr19 PE=1 SV=1 Q3UKC1 2 0 64,81 Tax1-binding protein 1 homolog OS=Mus musculus GN=Tax1bp1 PE=1 SV=2 Q3UKU1 1 0 34,51 RNA polymerase II elongation factor ELL2 OS=Mus musculus GN=Ell2 PE=1 SV=2 Q3UMC0 1 0 35,71 Spermatogenesis-associated protein 5 OS=Mus musculus GN=Spata5 PE=1 SV=2 Q3UUV5 1 0 25,69 Src kinase-associated phosphoprotein 1 OS=Mus musculus GN=Skap1 PE=1 SV=1 Q3UV16 1 0 27,04 Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 OS=Mus musculus GN=Itpripl2 PE=2 SV=1 Q3UW53 1 0 20,74 Protein Niban OS=Mus musculus GN=Fam129a PE=1 SV=2 Q3UWM4 1 0 30,89 Lysine-specific demethylase 7A OS=Mus musculus GN=Kdm7a PE=2 SV=2 Q3V0K9 3 0 122,40 Plastin-1 OS=Mus musculus GN=Pls1 PE=1 SV=1 Q3V079 2 0 65,21 Basal body-orientation factor 1 OS=Mus musculus GN=Ccdc176 PE=2 SV=2 Q4QY64 3 0 76,43 ATPase family AAA domain-containing protein 5 OS=Mus musculus GN=Atad5 PE=1 SV=1 Q4VA53 2 0 54,55 Sister chromatid cohesion protein PDS5 homolog B OS=Mus musculus GN=Pds5b PE=1 SV=1 Q5D525 1 0 32,94 Synaptonemal complex central element protein 1-like OS=Mus musculus GN=Syce1l PE=2 SV=2 Q5DU14 3 0 80,32 Unconventional myosin-XVI OS=Mus musculus GN=Myo16 PE=1 SV=2 Q5F204 1 0 39,76 Putative malate dehydrogenase 1B OS=Mus musculus GN=Mdh1b PE=2 SV=1 Q5F259 1 0 39,58 Ankyrin repeat domain-containing protein 13B OS=Mus musculus GN=Ankrd13b PE=2 SV=1 Q5QNQ6 2 0 134,08 Oxysterol-binding protein 2 OS=Mus musculus GN=Osbp2 PE=1 SV=1 Q5SX39 29 0 1872,88 Myosin-4 OS=Mus musculus GN=Myh4 PE=2 SV=1 Q5SX40 29 0 1746,51 Myosin-1 OS=Mus musculus GN=Myh1 PE=1 SV=1 Q5SYL3 2 0 65,29 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=1 SV=1 Q6A078 5 0 128,64 Centrosomal protein of 290 kDa OS=Mus musculus GN=Cep290 PE=1 SV=2 Q6DVA0 3 0 68,41 LEM domain-containing protein 2 OS=Mus musculus GN=Lemd2 PE=1 SV=1 Q6IEE6 1 0 23,79 Transmembrane protein 132E OS=Mus musculus GN=Tmem132e PE=1 SV=1 Q6NVF4 2 0 56,50 DNA helicase B OS=Mus musculus GN=Helb PE=1 SV=2 Q6P4T2 1 0 31,16 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Mus musculus GN=Snrnp200 PE=1 SV=1 Q6PAR5 1 0 39,03 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 Q6PE84 2 0 55,31 Stomatin-like protein 3 OS=Mus musculus GN=Stoml3 PE=1 SV=2 Q6PH08 1 0 36,64 ERC protein 2 OS=Mus musculus GN=Erc2 PE=1 SV=2 Q6PIC6 20 0 1413,39 Sodium/potassium-transporting ATPase subunit alpha-3 OS=Mus musculus GN=Atp1a3 PE=1 SV=1 Q6URW6 2 0 67,69 Myosin-14 OS=Mus musculus GN=Myh14 PE=1 SV=1 Q6V4S5 2 0 56,03 Protein sidekick-2 OS=Mus musculus GN=Sdk2 PE=1 SV=1 Q6VNB8 2 0 58,94 WD repeat and FYVE domain-containing protein 3 OS=Mus musculus GN=Wdfy3 PE=1 SV=1 Q6ZWR6 11 0 284,59 Nesprin-1 OS=Mus musculus GN=Syne1 PE=1 SV=2 Q7JJ13 3 0 98,92 Bromodomain-containing protein 2 OS=Mus musculus GN=Brd2 PE=1 SV=1 Q7TNK1 1 0 31,62 Transcription factor RFX4 OS=Mus musculus GN=Rfx4 PE=1 SV=1 Q8BFZ3 10 0 705,96 Beta-actin-like protein 2 OS=Mus musculus GN=Actbl2 PE=1 SV=1 Q8BGE5 1 0 38,81 Fanconi anemia group M protein homolog OS=Mus musculus GN=Fancm PE=1 SV=3 Q8BHP2 1 0 31,77 NUT family member 1 OS=Mus musculus GN=Nutm1 PE=1 SV=1 Q8BI06 1 0 24,88 -inducing and hyaluronan-binding protein OS=Mus musculus GN=Cemip PE=1 SV=4 Q8BJ34;Q9NYQ2 2 0 86,90 Meiosis arrest female protein 1 OS=Mus musculus GN=Marf1 PE=1 SV=3 Q8BND5 1 0 24,06 Sulfhydryl oxidase 1 OS=Mus musculus GN=Qsox1 PE=1 SV=1 Q8BPQ7 1 0 30,53 Small signaling modulator 1 OS=Mus musculus GN=Sgsm1 PE=1 SV=2 Q8BUK6 1 0 32,95 Protein Hook homolog 3 OS=Mus musculus GN=Hook3 PE=1 SV=2 Q8BUL5 1 0 29,77 Kelch-like protein 7 OS=Mus musculus GN=Klhl7 PE=2 SV=1 Q8BW96 4 0 105,19 Calcium/calmodulin-dependent protein kinase type 1D OS=Mus musculus GN=Camk1d PE=1 SV=2 Q8C3X4 1 0 95,46 Translation factor Guf1, mitochondrial OS=Mus musculus GN=Guf1 PE=1 SV=1 Q8C196 1 0 27,82 Carbamoyl-phosphate synthase [], mitochondrial OS=Mus musculus GN=Cps1 PE=1 SV=2 Q8CCJ3 1 0 33,95 E3 UFM1-protein ligase 1 OS=Mus musculus GN=Ufl1 PE=1 SV=2 Q8CEZ1 1 0 32,30 Single-pass membrane and coiled-coil domain-containing protein 1 OS=Mus musculus GN=Smco1 PE=2 SV=3 Q8CG71 1 0 59,22 Prolyl 3-hydroxylase 2 OS=Mus musculus GN=P3h2 PE=1 SV=1 Q8CGF1 2 0 56,50 Rho GTPase-activating protein 29 OS=Mus musculus GN=Arhgap29 PE=1 SV=1 Q8CHI8 2 0 61,23 E1A-binding protein p400 OS=Mus musculus GN=Ep400 PE=1 SV=3 Q8CHT6 1 0 36,95 Protein FAM169B OS=Mus musculus GN=Fam169b PE=2 SV=1 Q8JZR0 3 0 156,04 Long-chain-fatty-acid--CoA ligase 5 OS=Mus musculus GN=Acsl5 PE=1 SV=1 Q8K1T4 1 0 24,92 Lymphocyte antigen 6 complex locus protein G5b OS=Mus musculus GN=Ly6g5b PE=1 SV=1 Q8N9S3 2 0 58,27 Activator of 90 kDa heat shock protein ATPase homolog 2 OS=Mus musculus GN=Ahsa2 PE=1 SV=2 Q8QZW2 1 0 29,06 Protein FEV OS=Mus musculus GN=Fev PE=2 SV=1 Q8QZZ7 1 0 36,78 EKC/KEOPS complex subunit Tprkb OS=Mus musculus GN=Tprkb PE=1 SV=1 Q8R0W0 3 0 75,38 Epiplakin OS=Mus musculus GN=Eppk1 PE=1 SV=2 Q8R2K4 2 0 70,16 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Mus musculus GN=Taf6l PE=2 SV=1 Q8R4P5 1 0 33,94 Transmembrane channel-like protein 1 OS=Mus musculus GN=Tmc1 PE=1 SV=1

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1 SUPPLEMENTARY DATA

Q8R5F3 1 0 21,97 O-acetyl-ADP-ribose deacetylase 1 OS=Mus musculus GN=Oard1 PE=1 SV=2 Q8R429 22 0 1649,77 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Mus musculus GN=Atp2a1 PE=1 SV=1 Q8VC28 2 0 71,03 Aldo-keto reductase family 1 member C13 OS=Mus musculus GN=Akr1c13 PE=1 SV=2 Q8VCH0 8 0 436,86 3-ketoacyl-CoA thiolase B, peroxisomal OS=Mus musculus GN=Acaa1b PE=1 SV=1 Q8VDW0 3 0 105,47 ATP-dependent RNA helicase DDX39A OS=Mus musculus GN=Ddx39a PE=1 SV=1 Q9CQ56 1 0 33,03 Vesicle transport protein USE1 OS=Mus musculus GN=Use1 PE=1 SV=1 Q9CQC6 5 0 142,39 Basic leucine zipper and W2 domain-containing protein 1 OS=Mus musculus GN=Bzw1 PE=1 SV=1 Q9CQV5 1 0 42,04 28S ribosomal protein S24, mitochondrial OS=Mus musculus GN=Mrps24 PE=1 SV=1 Q9CQX0 1 0 50,50 Ubiquitin thioesterase OTUB2 OS=Mus musculus GN=Otub2 PE=1 SV=1 Q9CUU3 2 0 55,32 Synaptonemal complex protein 2 OS=Mus musculus GN=Sycp2 PE=1 SV=2 Q9CWY8 1 0 71,29 Ribonuclease H2 subunit A OS=Mus musculus GN=Rnaseh2a PE=1 SV=2 Q9D0B8 2 0 74,52 RIB43A-like with coiled-coils protein 1 OS=Mus musculus GN=Ribc1 PE=2 SV=1 Q9D6F9 19 0 1637,84 Tubulin beta-4A chain OS=Mus musculus GN=Tubb4a PE=1 SV=3 Q9D7J6 1 0 23,70 Deoxyribonuclease-1-like 1 OS=Mus musculus GN=Dnase1l1 PE=2 SV=3 Q9D662 2 0 161,54 Protein transport protein Sec23B OS=Mus musculus GN=Sec23b PE=1 SV=1 Q9DAZ9 2 0 49,75 Abscission/NoCut checkpoint regulator OS=Mus musculus GN=Zfyve19 PE=1 SV=2 Q9DBR3 1 0 35,99 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=1 SV=2 Q9DBT5 3 0 97,96 AMP deaminase 2 OS=Mus musculus GN=Ampd2 PE=1 SV=1 Q9EQ09 1 0 35,65 Oxidized low-density lipoprotein receptor 1 OS=Mus musculus GN=Olr1 PE=2 SV=2 Q9ERD7 11 0 884,77 Tubulin beta-3 chain OS=Mus musculus GN=Tubb3 PE=1 SV=1 Q9ES82 1 0 38,22 Popeye domain-containing protein 2 OS=Mus musculus GN=Popdc2 PE=1 SV=1 Q9ET77 2 0 96,63 Junctophilin-3 OS=Mus musculus GN=Jph3 PE=1 SV=1 Q9JKV7 1 0 41,26 Exostosin-like 1 OS=Mus musculus GN=Extl1 PE=2 SV=2 Q9JKW0 1 0 53,54 ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Mus musculus GN=Arl6ip1 PE=2 SV=1 Q9JM52 3 0 81,92 Misshapen-like kinase 1 OS=Mus musculus GN=Mink1 PE=1 SV=3 Q9QXY6 10 0 384,44 EH domain-containing protein 3 OS=Mus musculus GN=Ehd3 PE=1 SV=2 Q9QZZ4 1 0 29,01 Unconventional myosin-XV OS=Mus musculus GN=Myo15a PE=1 SV=2 Q9R0G7 2 0 52,78 Zinc finger E-box-binding homeobox 2 OS=Mus musculus GN=Zeb2 PE=1 SV=2 Q9R0K7 4 0 169,12 Plasma membrane calcium-transporting ATPase 2 OS=Mus musculus GN=Atp2b2 PE=1 SV=2 Q9R049 2 0 70,80 E3 ubiquitin-protein ligase AMFR OS=Mus musculus GN=Amfr PE=1 SV=2 Q9R244 1 0 32,94 Short transient receptor potential channel 2 OS=Mus musculus GN=Trpc2 PE=2 SV=2 Q9WUQ2 1 0 29,81 Prolactin regulatory element-binding protein OS=Mus musculus GN=Preb PE=1 SV=1 Q9WVA8 1 0 32,76 Pro-FMRFamide-related neuropeptide FF OS=Mus musculus GN=Npff PE=3 SV=1 Q9WVL2 2 0 31,90 Signal transducer and activator of transcription 2 OS=Mus musculus GN=Stat2 PE=1 SV=1 Q9WVM3 1 0 30,51 Anaphase-promoting complex subunit 7 OS=Mus musculus GN=Anapc7 PE=1 SV=3 Q9Z1W8 6 0 249,29 Potassium-transporting ATPase alpha chain 2 OS=Mus musculus GN=Atp12a PE=1 SV=3 Q9Z2G9 1 0 46,09 Oxidoreductase HTATIP2 OS=Mus musculus GN=Htatip2 PE=1 SV=3 Q9Z130 2 0 61,32 Heterogeneous nuclear ribonucleoprotein D-like OS=Mus musculus GN=Hnrnpdl PE=1 SV=1 Q9Z172 2 0 83,73 Small ubiquitin-related modifier 3 OS=Mus musculus GN=Sumo3 PE=1 SV=1 Q38HM4 3 0 109,94 E3 ubiquitin-protein ligase TRIM63 OS=Mus musculus GN=Trim63 PE=1 SV=1 Q68FE2 1 0 29,29 Autophagy-related protein 9A OS=Mus musculus GN=Atg9a PE=1 SV=1 Q69ZN7 3 0 51,87 Myoferlin OS=Mus musculus GN=Myof PE=1 SV=2 Q69ZQ2 1 0 30,88 Pre-mRNA-splicing factor ISY1 homolog OS=Mus musculus GN=Isy1 PE=1 SV=2 Q78PY7 2 0 46,45 Staphylococcal nuclease domain-containing protein 1 OS=Mus musculus GN=Snd1 PE=1 SV=1 Q80TF6 3 0 100,27 StAR-related lipid transfer protein 9 OS=Mus musculus GN=Stard9 PE=1 SV=2 Q80UK7 3 0 75,00 Spindle assembly abnormal protein 6 homolog OS=Mus musculus GN=Sass6 PE=2 SV=2 Q80V85 1 0 38,65 E3 ubiquitin-protein ligase TRIM62 OS=Mus musculus GN=Trim62 PE=2 SV=1 Q80ZJ7 1 0 35,91 Sorting nexin-32 OS=Mus musculus GN=Snx32 PE=2 SV=1 Q91VF6 1 0 30,57 Collagen alpha-1(XXVI) chain OS=Mus musculus GN=Col26a1 PE=1 SV=1 Q91W97 7 0 276,47 Putative hexokinase HKDC1 OS=Mus musculus GN=Hkdc1 PE=2 SV=1 Q91WC3 3 0 127,38 Long-chain-fatty-acid--CoA ligase 6 OS=Mus musculus GN=Acsl6 PE=1 SV=1 Q91ZR3 1 0 33,62 CREB/ATF bZIP transcription factor OS=Mus musculus GN=Crebzf PE=1 SV=2 Q99JY8 1 0 36,70 Lipid phosphate phosphohydrolase 3 OS=Mus musculus GN=Ppap2b PE=1 SV=1 Q99KE1 3 0 127,24 NAD-dependent malic enzyme, mitochondrial OS=Mus musculus GN=Me2 PE=1 SV=1 Q99MS7 3 0 90,69 EH domain-binding protein 1-like protein 1 OS=Mus musculus GN=Ehbp1l1 PE=1 SV=1 Q99MU3 2 0 58,39 Double-stranded RNA-specific OS=Mus musculus GN=Adar PE=1 SV=2 Q00896 23 0 2061,65 Alpha-1-antitrypsin 1-3 OS=Mus musculus GN=Serpina1c PE=1 SV=2 Q922F4 10 0 724,70 Tubulin beta-6 chain OS=Mus musculus GN=Tubb6 PE=1 SV=1 Q01776 1 0 29,61 Gonadotropin-releasing hormone receptor OS=Mus musculus GN=Gnrhr PE=2 SV=1 Q01815 1 0 22,94 Voltage-dependent L-type calcium channel subunit alpha-1C OS=Mus musculus GN=Cacna1c PE=1 SV=1 Q04736 1 0 42,48 Tyrosine-protein kinase Yes OS=Mus musculus GN=Yes1 PE=1 SV=3 Q07968 2 0 65,65 Coagulation factor XIII B chain OS=Mus musculus GN= PE=1 SV=2 Q60636 1 0 29,55 PR domain zinc finger protein 1 OS=Mus musculus GN=Prdm1 PE=1 SV=1 Q61043;P15066 5 0 153,23 Ninein OS=Mus musculus GN=Nin PE=1 SV=3 Q61085 1 0 31,09 Rhophilin-1 OS=Mus musculus GN=Rhpn1 PE=1 SV=2 Q61301 4 0 235,06 Catenin alpha-2 OS=Mus musculus GN=Ctnna2 PE=1 SV=3 Q61627 2 0 32,01 Glutamate receptor ionotropic, delta-1 OS=Mus musculus GN=Grid1 PE=1 SV=2 Q61789 1 0 29,35 Laminin subunit alpha-3 OS=Mus musculus GN=Lama3 PE=1 SV=4 Q61820 4 0 164,77 GTP-binding nuclear protein Ran, testis-specific isoform OS=Mus musculus GN=Rasl2-9 PE=2 SV=1 Q62148 4 0 151,05 Retinal dehydrogenase 2 OS=Mus musculus GN=Aldh1a2 PE=1 SV=2 Q62504 2 0 54,42 Msx2-interacting protein OS=Mus musculus GN=Spen PE=1 SV=2 Q64096 1 0 21,99 Guanine nucleotide exchange factor DBS OS=Mus musculus GN=Mcf2l PE=1 SV=2 Q64429 1 0 40,87 Cytochrome P450 1B1 OS=Mus musculus GN=Cyp1b1 PE=1 SV=3 Q64436 5 0 298,37 Potassium-transporting ATPase alpha chain 1 OS=Mus musculus GN=Atp4a PE=1 SV=3 Q64459 1 0 27,44 Cytochrome P450 3A11 OS=Mus musculus GN=Cyp3a11 PE=1 SV=1 Q64487 1 0 48,51 Receptor-type tyrosine-protein phosphatase delta OS=Mus musculus GN=Ptprd PE=1 SV=3

©2018 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db17-1195/-/DC1