PSB 6087 / PSB6088 Behavioral and Cognitive Neuroscience I and II

Professor: Darragh P. Devine, Ph.D. [email protected] Psychology Building room 324 273-2174 Office hours: T 11:45-12:35 and Th 12:50-1:40 p.m. Required Textbook: Principles of Neural Science, fifth edition. (2013), by E.R. Kandel, J.H. Schwartz, T.M. Jessell, S.A. Siegelbaum, and A.J. Hudspeth; ISBN #978-0071390118 COURSE OBJECTIVES: The purpose of this course is to provide a broad foundation (graduate level) in the neural basis of behaviour. Lectures and reading material will emphasize the cellular and molecular biology, anatomy, physiology, and development of the nervous system, neurobiology of sensation and motor function, motivational and regulatory systems, and cognitive neuroscience. The course is formulated primarily for first-year students in the Behavioral and Cognitive Neuroscience Program, and it is intended to assure that all students entering the program achieve equivalent levels of competence in the Behavioral Neurosciences. The textbook provides adequate coverage of all these topics and some additional topics. We will cover those topics that are essential to be well-versed in the subject matter of Behavioral Neuroscience [note, the reading load will be demanding during some portions of the course, and I strongly suggest that you read ahead of class meetings - so plan accordingly]. Additional topics will be left to the students to pursue according to their individual interests. Specialized and more advanced graduate courses will be available in the Behavioral and Cognitive Neuroscience program, the Department of Psychology, and in other departments in the university. The BCN-I and II course sequence will prepare students to undertake those courses.

GRADING: These courses will have three take-home exams and one optional final exam each semester. Each take-home exam will consist of a combination of multiple choice and short essay questions. Each take-home exam will cover only the text and lecture material from the chapters that have most recently been discussed in class. The final exam will be comprehensive (i.e. all the chapters that are covered during the semester). Students will receive a grade based upon the exams.

Each of the take-home exams will count 33⅓% toward your final grade. If you perform adequately on all take- home exams and are satisfied with your grade, you may skip the final exam. If you fail to turn in a take-home exam on time, or if you do poorly on an exam, you can drop that exam/grade and take the final exam to replace it. In this case your three best exam scores will each count 33⅓% of your total grade.

The final is the only option for a missed or failed exam. There will be no additional makeup tests under any circumstances. A penalty of 10% per day will be imposed for any examination that is turned in late.

The grading scheme is as follows: A 93-100 C 73-76 A- 90-92 C- 70-72 B+ 87-89 D+ 67-69 B 83-86 D 63-66 B- 80-82 D- 60-62 C+ 77-79 E <60 WEBSITE: Images from lectures will be available for students to review at the course website. The website is found in the E-Learning system at: https://lss.at.ufl.edu It is very important for students to access this site. If you experience any difficulty, contact me as early as possible. Additional materials and interesting links will also be posted on this site.

BCN I COURSE SCHEDULE: (This schedule is tentative [and ambitious]. It will likely be modified during the semester.) Approximate Dates Chapter Topic PART I. OVERALL PERSPECTIVE week 1-2 (Aug 21-28) Ch. 1: The Brain and Behavior week 2-4 (Aug 30-Sept 13) Ch. 2: Nerve Cells, Neural Circuitry, and Behavior week 5-6 (Sept 18 - 25) Ch. 3: Genes and Behavior week 6-7 (Sept 27-Oct 2) Ch. 4: The Cells of the Nervous System week 7 take-home exam #1: Ch. 1 - 4, and all material from lectures (due October 11) PART II. CELL AND MOLECULAR BIOLOGY OF THE NEURON week 7-8 (Oct 2-9) Ch. 5: Ion Channels week 8-9 (Oct 11-16) Ch. 6: Membrane Potentials and the Passive Electrical Properties of Neurons week 9 (Oct 18) Ch. 7: Propagated Signaling: The Action Potential week 10 (Oct 23) Ch. 8: Overview of Synaptic Transmission week 10 (Oct 25) Ch. 9: Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission week 11 (Oct 30-Nov 1) Ch. 10: Synaptic Integration in the Central Nervous System week 12 take-home exam #2: Ch. 4 - 7, and all material from lectures (due Nov 16) PART III. SYNAPTIC TRANSMISSION week 12-13 (Nov 6-13) Ch. 11: Modulation of Synaptic Transmission: Second Messengers week 13-14 (Nov 15-20) Ch. 12: Transmitter Release week 14 (Nov 22) Thanksgiving - no class week 15 (Nov 27-29) Ch. 13: Neurotransmitters (We will skip chapter 14) PART IV. THE NEURAL BASIS OF COGNITION week 16 (Dec 4-6) Ch. 15: The Organization of the Central Nervous System week 16 take-home exam #3: Ch. 8 - 13, and all material from lectures (due Dec 9) final exam period COMPREHENSIVE FINAL EXAM (chapters 1-13, 15 and lectures; due Dec 15)

BCN II COURSE SCHEDULE: (This schedule is tentative [and ambitious]. It will likely be modified during the semester.) Approximate Dates Chapter Topic PART IV. THE NEURAL BASIS OF COGNITION week 1 (Jan 8) no class week 1 (Jan 10) Ch. 16: The Functional Organization of Perception and Movement week 2 (Jan 15) MLK - no class week 2 (Jan 17) Ch. 17: From Nerve Cells to Cognition: Internal Rep of Space and Action week 3 (Jan 22-24) Ch. 18: The Organization of Cognition week 4 (Jan 29-31) Ch. 19: Cognitive Functions of the Premotor Systems week 5 (Feb 5-7) Ch. 20: Functional Imaging of Cognition week 6 take-home exam #1: Ch. 15 - 20, and all material from lectures (due Feb 16) PART VIII. DEVELOPMENT AND THE EMERGENCE OF BEHAVIOR week 6 (Feb 12) Ch. 52: Patterning the Nervous System week 6 (Feb 14) Ch. 53: Differentiation and Survival of Nerve Cells week 7 (Feb 19) Ch. 54: The Growth and Guidance of Axons week 7 (Feb 21) Ch. 55: Formation and Elimination of Synapses week 8 (Feb 26) Ch. 56: Experience and the Refinement of Synaptic Connections week 8 (Feb 28) Ch. 57: Repairing the Damaged Brain week 9 (March 5 - 7) Spring Break - no class week 10 (March 12) Ch. 58: Sexual Differentiation of the Nervous System week 10 (March 14) Ch. 59: The Aging Brain week 11 take-home exam #2: Ch. 52 - 59, and all material covered in lectures (due March 23) Part V. PERCEPTION AND PART VI. MOVEMENT week 11 (March 19 - 22) Ch. 21: Sensory Coding week 11 (March 21) Ch. 33: The Organization and Planning of Movement week 12 (March 26-28) Ch. 36: Locomotion week 13 (April 2) Ch. 42: The Cerebellum week 13 (April 4) Ch. 43: The Basal Ganglia PART VII. THE UNCONSCIOUS AND CONSCIOUS PROCESSING OF NEURAL INFORMATION week 14 (April 9) Ch. 47: The Autonomic Motor System and the Hypothalamus week 14 (April 11) Ch. 48: Emotions and Feelings week 15 (April 16 - 18) Ch. 49: Homeostasis, Motivation, and Addictive States PART IX. LANGUAGE, THOUGHT, AFFECT, AND LEARNING week 16 (April 23 - 25) Ch. 60: Language week 16 take-home exam #3: Ch. 21, 33, 36, 42-43, 47-49, and all material from lectures (due April 27) final exam period COMPREHENSIVE FINAL EXAM (all chapters and lectures; due May 4)

ADDITIONAL SUPPORT FOR STUDENTS WITH DISABILITIES: Students requesting classroom accommodation must first register with the Dean of Students Office. The Dean of Students Office will provide documentation to the student who must then provide this documentation to the Instructor when requesting accommodation.

ACADEMIC HONESTY GUIDELINES: The academic community of students and faculty at the University of Florida strives to develop, sustain and protect an environment of honesty, trust and respect. Students are expected to pursue knowledge with integrity. Exhibiting honesty in academic pursuits and reporting violations of the Academic Honesty Guidelines will encourage others to act with integrity. Violations of the Academic Honesty Guidelines shall result in judicial action and a student being subject to the sanctions in paragraph XI of the Student Conduct Code. The conduct set forth hereinafter constitutes a violation of the Academic Honesty Guidelines (University of Florida Rule 6C1-4.017).

Cheating. The improper taking or tendering of any information or material which shall be used to determine academic credit. Taking of information includes, but is not limited to, copying graded homework assignments from another student; working together with another individual(s) on a take-home test or homework when not specifically permitted by the teacher; looking or attempting to look at another student's paper during an examination; looking or attempting to look at text or notes during an examination when not permitted. The tendering of information includes, but is not limited to, giving of your work to another student to be used or copied; giving someone answers to exam questions either when the exam is being given or after taking an exam; giving or selling a term paper or other written materials to another student; sharing information on a graded assignment. Plagiarism. The attempt to represent the work of another as the product of one's own thought, whether the work is published or unpublished, or simply the work of a fellow student. Plagiarism includes, but is not limited to, quoting oral or written materials without citation on an exam, term paper, homework, or other written materials or oral presentations for an academic requirement; submitting a paper which was purchased from a term paper service as your own work; submitting anyone else's paper as your own work. NOTE – If you copy and paste materials from another author into your work, this constitutes plagiarism, no matter how many words you change. ALL WRITING ON EXAMS AND PAPERS MUST BE COMPLETELY ORIGINAL. All written assignments will be reviewed using Turnitin.com. Any instance of cheating or plagiarism will result in a failing grade for the course, with no exceptions. Bribery. The offering, giving, receiving, or soliciting of any materials, items or services of value to gain academic advantage for yourself or another. Misrepresentation. Any act or omission with intent to deceive a teacher for academic advantage. Misrepresentation includes using computer programs generated by another and handing it in as your own work unless expressly allowed by the teacher; lying to a teacher to increase your grade; lying or misrepresenting facts when confronted with an allegation of academic dishonesty. Conspiracy. The planning or acting with one or more persons to commit any form of academic dishonesty to gain academic advantage for yourself or another. Fabrication. The use of invented or fabricated information or the falsification of research or other findings with the intent to deceive for academic or professional advantage. UF's Academic Honesty Policy is clearly stated in rule 6Cl-4.0l7 Student Affairs: Academic Honesty Guidelines.