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9th International Symposium on the Clinical Use of Cellular Products

First Program

Cellular Therapy 2017 March 16 and 17, 2017, Erlangen,

Universitatsklinikum Erlangen

Universitatsklinikum Erlangen

First Program

9th International Symposium on the Clinical Use of Cellular Products Cellular Therapy 2017

March 16 and 17, 2017

Department of Internal Medicine 5 – Hematology/Oncology University of Erlangen-

Department of Dermatology University of Erlangen-Nuremberg

Department of Internal Medicine 3 – Hematology/Oncology Unversity of

Department of Internal Medicine 2 – Hematology/Oncology University of Würzburg Dear Colleagues.

On behalf of the organizing committee we would like to invite you to join us for the 9th International Cellular Therapy Symposium, to be held in Erlangen, Germany, from March 16 to 17, 2017. The Cellular Therapy Symposium will be co-organized by the Universities of Erlangen-Nuremberg (A. Mackensen; G. Schuler), Regensburg (W. Herr), and Würzburg (H. Einsele).

Recent advances in protein engineering and molecular biology have increased the feasibility of cellular therapies such as genetically engineered T cells (CARs & TCRs) to treat malignant diseases.

Over the past years the meeting has evolved to a widely respected event, attracting experts from all over the world to discuss recent topics of the field in a pleasant environment. The upcoming meeting 2017 will focus on immune effector/suppressor cells, CAR/TCR-engineered T-cell therapy, immunological checkpoints, antigen presenting cells / B cells, and immunometabolism.

We are sure that your participation will contribute making the meeting exciting and successful. You are cordially invited to join us at this symposium in the beautiful city of Erlangen.

Yours sincerely

Prof. Andreas Mackensen Universitatsklinikum Erlangen

Organizer: Andreas Mackensen, Erlangen Gerold Schuler, Erlangen Wolfgang Herr, Regensburg Herrmann Einsele, Würzburg

Scientific Committee: Hinrich Abken, Köln Philipp Beckhove, Regensburg Diana Dudziak, Erlangen Matthias Edinger, Regensburg Hermann Einsele, Würzburg Armin Gerbitz, Wolfgang Herr, Regensburg Michael Hudecek, Würzburg Petra Hoffmann, Regensburg Anita Kremer, Erlangen Marina Kreutz, Regensburg Andreas Mackensen, Erlangen Dimitrios Mougiakakos, Erlangen Evelyn Ullrich, Wolfgang Uckert, Berlin Claudia Rössig, Münster Simone Thomas, Regensburg Gerold Schuler, Erlangen Thomas Winkler, Erlangen Robert Zeiser, Freiburg

Congress Secretary: PD Dr. Dimitrios Mougiakakos Department of Internal Medicine 5 – Hematology and Oncology Ulmenweg 18 D-91054 Erlangen, Germany Phone: +49-9131-85 35954 Fax: +49-9131-85 35958 E-mail: [email protected]

Location: Hörsäle Medizin Universitätsklinikum Erlangen Ulmenweg 18 D-91054 Erlangen, Germany Thursday March 16, 2017

Session I

Immune Effector/Suppressor Cells

09.00 h – 11.15 h

■ Targeting cancer-specific mutations for T-cell therapy Hans Schreiber (Chicago)

■ Myeloid-derived suppressor cells Vincenzo Bronte (Verona)

■ γδ T cells for cancer immunotherapy Jürgen Kuball (Utrecht)

2 – 3 short presentations (selected from submitted abstracts) Universitatsklinikum Erlangen

Thursday March 16, 2017

Session II

TCR-engineered T-Cell Therapy

13.30 h – 15.30 h

■ TCR engineered T-cell immunotherapy Nicholas Restifo (Bethesda)

■ Optimizing T-cell receptor gene therapy for hematologic malignancies Hans M. Stauss (London)

■ T-cell therapy in pancreatic cancer Rink Offringa ()

2 – 3 short presentations (selected from submitted abstracts) Thursday March 16, 2017

Session III

CAR T-Cell Therapy

16.00 h – 18.15 h

■ CAR T cells in leukemia and myeloma Carl H. June (Philadelphia)

■ Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape Nabil M. Ahmed (Houston)

■ Engineering regulatory T cells with chimeric antigen receptors Megan K. Levings (Vancouver)

2 – 3 short presentations (selected from submitted abstracts) Universitatsklinikum Erlangen

Friday March 17, 2017

Session IV

Immunological Checkpoints

09.00 h – 11.15 h

■ PD-L1 and PD-1 pathway blockade for cancer therapy: biomarkers and potential combinations Lieping Chen (Yale)

■ Immunological checkpoints George Coukos (Lausanne)

■ Targeting novel immune checkpoints Philipp Beckhove (Regensburg)

2 – 3 short presentations (selected from submitted abstracts) Friday March 17, 2017

Session V

Antigen Presenting Cells/B-Cells

12.00 h – 14.00 h

■ Molecular mechanisms of antigen processing Peter Cresswell (Yale)

■ Dendritic cell and macrophage ontogeny Florent Ginhoux (Singapore)

■ Trastuzumab emtansine renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade Alfred Zippelius (Basel)

2 – 3 short presentations (selected from submitted abstracts) Universitatsklinikum Erlangen

Friday March 17, 2017

Session VI

Immunometabolism

14.15 h – 16.15 h

■ Overcoming metabolic checkpoints to anti-tumor immunity Greg M. Delgoffe (Pittsburgh)

■ Immunometabolic regulation of lymphocyte function Christoph Hess (Basel)

■ Metabolic checkpoints of anti-tumor T cell responses Ping-Chih Ho (Lausanne) General Information

Scientific Sessions:

■ Immune Effector/Suppressor Cells ■ CAR/TCR-engineered T-Cell Therapy ■ Immunological Checkpoints ■ Antigen Presenting Cells / B-Lymphocytes ■ Immunometabolism

Submission of Abstracts: Deadline: January 20, 2017

Abstract submission will be available on the Cellular Therapy website beginning November 1, 2016. To submit an abstract for consideration and review, please go to

http://www.cellular-therapy.de

and click on Abstract Submission icon. Submission instructions and guidelines will appear.

All abstracts selected for oral or poster presentation will be printed in an abstract book, available to the participants. Universitatsklinikum Erlangen

Registration:

Participants are given the opportunity to register for the symposium online. Please adhere to the instructions given on the symposium website

http://www.cellular-therapy.de

Registration fee:

Pre-registration On site- (before Feb. 15, 2017) registration

Full Registration: 275 € 350 €

Students: 150 € 225 €

Members of Uni R or ER or WÜ: 75 € 100 €

The registration fee covers conference volume, coffee breaks, lunch and social event

Please register early as attendance will be limited to 350 participants!!! Hotel Reservation:

For further information please contact:

Erlanger Tourismus und Marketing Verein e.V. Carree am Rathausplatz Rathausplatz 3 91052 Erlangen Phone: ++49 (0)9131 8951-11 Fax: ++49 (0)9131 8951-51 E-mail: [email protected] E-mail: [email protected]

Poster Presentation:

Posters (100 cm wide and 120 cm high) Deadline for abstracts: January 20, 2017 Universitatsklinikum Erlangen Congress Secretary: PD Dr. Dimitrios Mougiakakos Department of Internal Medicine 5 – Hematology and Oncology Ulmenweg 18 D-91054 Erlangen, Germany Phone: +49-9131-85 35954 Fax: +49-9131-85 35958 E-mail: [email protected]