IUB No. name Source Approved in EC 1,4-alpha-glucan Bacillus subtilis JECFA, Denmark, France, Brazil, 2.4.1.18 branching enzyme USA (GRAS Notice No. GRN 00274) Alpha-acetolactate Bacillus subtilis expressed in USA 21 CFR 173.115 decarboxylase Bacillus brevis EC 3.2.1.1 Alpha amylase Aspergillus niger Australia/New Zealand, Canada, France, Brazil, Mexico, USA (GRN 89)

Aspergillus oryzae Australia/New Zealand, Canada, France, Brazil, Mexico, USA (GRN 90)

Bacillus amyloliquefaciens Australia and New Zealand, Canada, Mexico, Brazil, USA 21 CFR 184.1148

Bacillus licheniformis Belgium, France, China, Japan, Denmark, Australia and New Zealand, Canada, Mexico, Brazil

Bacillus licheniformis expressed Australia/New Zealand, Canada, in Bacillus licheniformis France, Brazil, Denmark, Mexico, USA GRAS Notice No. GRN 000079, JECFA

Bacillus licheniformis and GRAS Notice No. GRN 00022, Bacillus amyloliquefaciens Brazil, Mexico expressed in Bacillus licheniformis

Bacillus amyloliquefaciens Brazil, Denmark, France expressed in Bacillus licheniformis

Bacillus megaterium expressed JECFA, Canada, Brazil, Mexico in Bacillus subtilis

Bacillus stearothermophilus JECFA, Canada, Brazil, Mexico, USA 21 CFR 184.1012

Bacillus stearothermophilus Australia/New Zealand, Canada, expressed in Bacillus France, Brazil, Denmark, Mexico, licheniformis Japan, GRAS Notice No. GRN 000024

Bacillus stearothermophilus Australia/New Zealand, Canada, expressed in Bacillus subtilis France, Brazil, Denmark, Mexico

Bacillus stearothermophilus Australia/New Zealand, Canada, (Geobacillus France, Europa, Brazil, Mexico, stearothermophilus) USA (GRN 594)

Bacillus subtilis Australia and New Zealand, Canada, Mexico, Brazil, USA 21 CFR 184.1148

Rhizopus delemar Brazil

Rhizopus oryzae Brazil, Mexico, USA GRAS Notice No. GRN 000090

Thermoccocales expressed in Brazil, USA (GRN126) Pseudomonas fluorecens

Rhizomucor pusillus expressed Brazil, Denmark, France, Mexico, in Aspergillus niger Australia and New Zealand.

Thermoactinomyces vulgaris expressed in B. subtilis

Alicyclobacillus pohliae Canada, Denmark, Mexico expressed in Bacillus subtillis

Cytophaga sp. expressed in USA (GRAS Notice No. GRN 604) Bacillus licheniformis

Aspergillus kawachii expressed France in Trichoderma reesei

Barley malt, malted cereals USA 21 CFR 184.1443a

Pseudomonas fluorecens Canada, France

Trichoderma reesei Denmark, France EC 4.1.1.5 Alfa-acetolactate Bacillus brevis expressed in Australia/New Zealand, Canada, decarboxylase Bacillus subtilis France, Europe, JECFA, Brazil, Denmark

Bacillus brevis expressed in Brazil, Denmark, France, Mexico, Bacillus licheniformis Canada, GRAS Notice No. GRN 00587, Bacillus subtilis Australia, Denmark

Bacillus amyloliquefaciens Australia

Bacillus licheniformis Denmark EC 3.2.1.1 Alpha- Aspergillus niger Brazil, Mexico, New Zealand, galactosidase Australia

Mortierella vinacea Brazil, Mexico, USA 21 CFR 173.145

Saccharomyces carlsbergensis Brazil, Mexico

EC Maltogenic Bacillus stearothermophilus Brazil, Australia, Canada, China, 3.2.1.133 amylase expressed in Bacillus France, JECFA, Japan, Denmark, licheniformis Mexico, USA (GRN 751)

Bacillus stearothermophilus Brazil, Mexico, Canada, China, expressed in Bacillus subtilis France, JECFA, USA (GRN 746 y GRN 751)

Pseudomonas stutzeri Australia and New Zealand, expressed in Bacillus Canada, Mexico, Brazil licheniformis

Geobacillus stearothermophilus Canada, China, France, JECFA, expressed in Bacillus subtilis Japan, Australia, Denmark, Brazil, Mexico, USA (GRN 751) EC 3.2.1.3 Amyloglucosidase Aspergillus niger var. awamori Canada, Brazil or Glucoamylase Aspergillus niger Australia and New Zealand, Canada, France, Brazil, Mexico, Japan, Denmark, USA (GRN 89)

Aspergillus niger expressed in Brazil, Mexico, Australia and New Aspergillus niger Zealand, Canada, Mexico, USA (GRN 751)

Aspergillus oryzae JECFA, Australia and New Zealand, Canada, France, Brazil, Mexico, USA (GRN 90)

Rhizopus arrhizus Australia and New Zealand, Canada, Brazil, Mexico

Rhizopus delemar Australia and New Zealand, Brazil

Rhizopus niveus Mexico, Australia and New Zealand, Brazil, USA 21 CFR 173.110

Rhizopus oryzae Mexico, Australia and New Zealand, Brazil, USA (GRN 90)

Talaromyces emersonii Brazil, Canada, China, Denmark, expressed in Aspergillus niger France, Mexico

Trichoderma reesei Brazil

Trametes cingulata expressed in Denmark, France Aspergillus niger

Trichoderma reesei expressed Brazil, USA (GRN 372), JECFA in Trichoderma reesei

Gloeophyllum trebeum Brazil, Denmark, France, Mexico expressed in Aspergillus niger

Rhizopus delemar var. multiplicisporus

Aspergillus fumigatus expressed Mexico in Trichoderma reesei

Fusarium verticilloides Mexico expressed in Trichoderma reesei

Penicillium oxalicum expressed Denmark, Mexico, in Aspergillus niger

Glucoamylase de Aspergillus Canada niger 41SAM2-54 EC Amylomaltase Thermus thermophilus Australia/New Zealand, Canada, 2.4.1.25 expressed in Bacillus USA (GRN 507) amyloliquefaciens

Aspergillus oryzae USA (GRAS Notice GRN No. 274)

Aspergillus oryzae USA (GRN 274)

Bacillus amyloliquefaciens Australia Aminoglycoside 3′- Eschericha coli expressed in USA (21 CFR 173.170) phosphotransferas Eschericha coli e II Eschericha coli expressed in USA 21 CFR 173.170 Eschericha coli EC Aminopeptidase Lactococcus lactis USA GRAS 3445, Brazil, 3.4.11.1 Australia/New Zealand, Canada

Aspergillus oryzae Australia/New Zealand, China, France, Denmark, USA (GRN 90)

Lactococcus lactis USA 21 CFR 184.1985 (Streptococcus lactis) EC 3.5.4.6 AMP deaminase Aspergillus melleus China, Denmark, France, Japan

Streptomyces murinus Japan EC Arabinofuranosidas Talaromyces pinophilus Denmark, Mexico, USA (GRN 3.2.1.55 e expressed in Trichoderma 000680) reesei

Aspergillus niger Australia, China, France, JECFA EC 3.5.1.1 Asparaginase Aspergillus niger expressed in Australia/New Zealand, Brazil, Aspergillus niger Canada, China, Denmark, France, JECFA, Mexico, USA (GRN 214)

Aspergillus oryzae expressed in Australia/New Zealand Brazil, Aspergillus oryzae Mexico, Europe, Denmark, France, Canada, China, JECFA, Mexico, USA (GRN 201)

Pyrococcus furiosus expressed Australia/New Zealand Brazil, in Bacillus subtilis Mexico, Europe, Denmark, Canada, USA (GRN 476), France

Aspergillus niger Australia

Aspergillus oryzae JECFA, Denmark, France, Brazil

Bacillus subtilis Denmark, France, Brazil EC 3.4.23 Aspartic Cynara cardunculus L. USA (GRAS Notice GRN No. 551)

Cynara cardunculus L. USA (GRN 551) EC 3.2.1.2 Beta-amylase Bacillus licheniformis Denmark

Bacillus cereus Brazil

Bacillus megaterium Brazil

Bacillus subtilis Brazil

Bacillus flexus expressed in Brazil, Mexico, Denmark, France, Bacillus licheniformis USA (GRAS)

Cebeda 21 CFR 184.1443a EC 3.2.1.6 Beta-glucanase Aspergillus aculeatus Australia/New Zealand, Brazil, Canada, China, Denmark, France, Mexico

Aspergillus niger Brazil, Canada, France

Bacillus subtilis Brazil, Canada, France

Disporotrichum Brazil, Canada, USA (GRN 482) dimorphosphorum

Humicola insolens Brazil, Canada, France. USA (GRN 195)

Penicillium emersonii Brazil

Talaromyces emersonii Brazil, Canada, France, USA (GRN 479), Australia

Trichoderma harzianum Brazil, Canada, France

Trichoderma longibrachiatum Brazil

Trichoderma reesei Brazil, Canada, France, Australia, JECFA

Penicillium funiculosum USA (GRN 584)

Bacillus subtilis expressed in USA (GRN 592) Bacillus subtilis

Rasamsonia composticola Beta-glucosidase Aspergillus niger Brazil or cellobiase Trichoderma harzianum Brazil

Trichoderma reesei Brazil EC Beta-glucosidase Apergillus niger Brazil, USA (GRN 750) 3.2.1.21 E.C. Bromelain Ananas comosus USA 21 CFR 184.1024 3.4.22.32 A. bracteatus L. USA 21 CFR 184.1024 EC 3.2.1.3 Carbohydrase Bacillus licheniformis Mexico

Rhizopus oryzae USA (GRAS Notice GRN No. 90, 21 CFR 173.130)

Aspergillus niger USA 21 CFR 173.120 EC 3.2.1.3 Diastase Rhizopus oryzae JECFA, Mexico, Brazil, USA (GRAS Notice GRN No. 90) 3.4.16.5 Carboxypeptidase Aspergillus niger expressed in Canada, Denmark, France, Mexico, C Aspergillus niger Russia, USA (GRN 435) EC Catalase Aspergillus niger Australia/New Zealand, Brazil, 1.11.1.6 Canada, China, France, USA (GRN 89), Mexico

Micrococcus lysodeicticus USA 21 CFR 173.135, Canada, (micrococcus juteus) JECFA, Brazil, Mexico

Aspergillus niger expressed in Australia/New Zealand, USA (GRN Aspergillus niger 89)

Bovine liver USA 21 CFR 184.1034 EC 3.2.1.4 Cellulase Aspergillus niger Brazil, Mexico, Australia, New Zeland, Canada, JECFA, USA (GRN 89)

Aspergillus oryzae Brazil, USA (GRN 90)

Penicillium funiculosum Brazil, JECFA, USA (GRN 584)

Rhizopus delemar Brazil

Rhizopus oryzae Brazil

Sporotrichum dimorphosporum Brazil

Thielavia terrestris Brazil

Trichoderma longibrachiatum Brazil, Australia/New Zealand, Canada, China, Denmark, France, Mexico

Trichoderma reesei Brazil, Canada, USA 21 CFR 184.1250

Rasamsonia (Talaromyces) JECFA, USA (GRAS GRN 479) emersonii

Trichoderma viride Australia EC Cyclodextrin Bacillus licheniformis Denmark, France 2.4.1.19 glucanotransferase Paenibacillus macerans Australia

Thermoanaerobacter sp. expressed in Bacillus China, Denmark, France licheniformis EC D-Allulose 3- Arthrobacter globiformis USA (GRN 624) 5.1.3.30 epimerase expressed in E. coli K-12 W3110 EC Dextranase Bacillus subtilis Brazil 3.2.1.11 Chaetomium erraticum Brazil, Australia, New Zeland, Brazil, Denmark, USA GRAS GRN 000027

Chaetomium gracile Brazil

Klebsiella aerogenes Brazil

Penicillium funiculosum Brazil

Penicillium lilacinum Brazil Branching enzyme Rhodothermus obamensis Brazil Milk clotting Endothia parasitica USA 21 CFR 173.150 Bacillus cereus USA 21 CFR 173.150

Mucor pusillus Lindt USA 21 CFR 173.150

Mucor miehei Cooney et USA 21 CFR 173.150 Emerson

Aspergillus oryzae USA 21 CFR 173.150 Esterase Aspergillus niger Brazil

Mucor miehei Australia, New Zeland, Brazil, Denmark, USA 21 CFR 173.140 EC 3.1.3.8 Phytase Aspergillus niger Brazil

Aspergillus niger expressed in Brazil, Australia, France, JECFA Aspergillus niger Ficin Ficus USA 21 CFR 184.1316

EC Phosfatidylcoline Aeromonas salmonicida Brazil, Australia, GRAS GRN 265 2.3.1.43 sterol O- expressed in Bacillus acyltransferase licheniformis EC 3.1.4.1 Phosphodiesterase Leptographium procerum Denmark, France, USA (GRN 505) I EC Phosphoinositide Pseudomonas fluorescens USA (GRAS GRN 574) 3.1.4.11 phospholipase C Pseudomonas fluorescens gene extracted from soil sample

Pseudomonas sp-62186 expressed in Bacillus Denmark, USA (GRAS GRN 728), licheniformis Canada, Mexico

EC Phospholipase A1 Fusarium venenatum expressed Brazil, USA (GRN 142), Australia, 3.1.1.32 in Aspergillus oryzae Canada, China, Denmark, France, Mexico

Talaromyces leycettanus Denmark, France, USA (GRN 651) expressed in Aspergillus niger EC 3.1.1.4 Phospholipase A2 Streptomyces violaceoruber Brazil, USA (GRN 145)

A. nishimurae (ex fumigatus) USA (GRN 524) expressed in T. reesei

Aspergillus niger Australia, Canada, China, Denmark, France, Japan

S. violaceoruber expressed in USA (GRN 212) Streptomyces violaceoruber

Porcine pancreas expressed in USA (GRN 183) Aspergillus niger

A. nishimurae (ex fumigatus) France, USA GRAS #524, Mexico expressed in EC 3.1.4.3 Phospholipase C Pichia pastoris Brazil, Argentina, Canada, China, France, JECFA, Mexico, USA (GRAS GRN 204)

Bacillus thuringiensis expressed Denmark, USA GRN (689), Canada in Bacillus licheniformis

Pseudomonas sp. 62186 Canada, Denmark, USA (GRN expressed in Bacillus 728) licheniformis

Pichia pastoris gene extracted from soil sample

EC 3.2.1.6 Glucanase Aspergillus niger Canada

Bacillus amyloliquefaciens Canada

Bacillus subtillis Canada Rasamsonia emersonii Canada (Talaromyces emersonii)

Humicola insolens Australia/New Zealand, Brazil, China, Denmark, France, Mexico, Canada, USA (GRN 195)

Trichoderma reesei JECFA, Australia e Brazil (longibrachiatum) expressed in Trichoderma reesei (longibrachiatum)

Bacillus amyloliquefaciens Australia, China, France expressed in Bacillus amyloliquefaciens

Geosmithia emersonii Australia, Brazil

Trichoderma reesei Australia/New Zealand, Brazil, Canada, France, JECFA, China, Singapore, South Korea

Trichoderma harzianum Brazil, China, JECFA, USA (GRN 149), EC Glucanase Streptomyces violaceoruber JECFA, USA (GRAS GRN 728), 3.2.1.39 expressed in Streptomyces Brazil, Japan violaceoruber EC Glucanase (beta) Disporotrichum Canada 3.2.1.58 dimorphosporum EC 3.2.1.6 endo-1,3(4)-β- T. reesei expressed in T. reesei France, Denmark, Australia, USA glucanase 21 CFR EC 5.3.1.5 Glucose Actinoplanes missourienses Autralia, New Zeland, Canada, JECFA, France, Brazil, Mexico

Bacillus coagulans Autralia, New Zeland, Canada, JECFA, France, Brazil, Mexico, USA 21 CFR 184.1372 Microbacterium arborensens Brazil, Mexico

Streptomyces albus Brazil

Streptomyces murinus Brazil, Australia, New Zealand, Canada, Denmark, France, Mexico

Streptomyces olivaceus Brazil, USA 21 CFR 184.1372

Streptomyces Brazil, USA 21 CFR 184.1372 olivochromogenes

Streptomyces rubiginosus Brazil, USA 21 CFR 184.1372

Streptomyces violaceoniger Brazil

Penicillium chrysogenum Denmark, France expressed in Aspergillus niger

Actinoplanes missouriensis USA 21 CFR 184.1372

Aspergillus niger Brazil, China, Australia and New Zealand, USA (GRN 89)

Aspergillus oryzae Brazil, Mexico, Denmark, USA GRAS GRN 000106

Aspergillus niger expressed in Brazil Aspergillus niger

Aspergillus niger expressed in Brazil Aspergillus oryzae

Penicillium amagasakiense Brazil

Streptomyces rubiginosus Mexico expressed in Streptomyces rubiginosus EC 1.1.3.4 Glucose oxidase Australia/New Zealand, Brazil, Aspergillus niger Canada, China, Denmark, France, Mexico, USA (GRN 89)

Aspergillus oryzae USA (GRN 106)

Aspergillus niger expressed in Aspergillus niger

Aspergillus niger expressed in Australia/New Zealand, Brazil, Aspergillus oryzae Canada, China, Denmark, France, Mexico, USA (GRN 106)

Penicillium amagasakiense

Penicillium chrysogenum Brazil, Denmark, France expressed in Aspergillus niger

Penicillium amagasakiense France, Denmark, Canada, USA expressed in T. reesei GRAS #707 EC Glutaminase Chryseobacterium proteolyticum Brazil, USA (GRAS GRN 000267), 3.5.1.44 France

Bacillus licheniformis expressed USA (GRN 774) in Bacillus licheniformis

Protein-glutaminase from Chryseobacterium proteolyticum Canada AE-PG EC Hemicellulase Humicola insolens Australia, Nueva Zelanda 3.2.1.32 endo-1,3-β- xylanase Hemicellulase Aspergillus niger Australia, Nueva Zelanda, Brazil

Aspergillus oryzae Brazil

Bacillus subtilis Australia, Nueva Zelanda, Canada, Brazil

Rhizopus delemar Brazil

Rhizopus oryzae Brazil

Sporotrichum dimorphosporum Brazil EC 3.2.1.8 Hemicellulase Trichoderma reesei Australia, Nueva Zelanda, Brazil EC 3.2.1.78 Bacillus amyloliquefaciens Australia, Nueva Zelanda

Bacillus amyloliquefaciens Australia EC 1.1.3.5 Hexose oxidase Chondrus crispus expressed in Brazil, JECFA, Mexico Hansenula polymorpha EC 3.2.1.7 Inulinase Aspergillus niger Australia, Nueva Zelanda, France, Brazil, China, Mexico, USA (GRN 89)

Kluyveromyces fragilis Brazil, Mexico

Sporotrichum dimorphosporum Brazil, Mexico EC Invertase Aspergillus niger Brazil 3.2.1.26 Bacillus subtilis Brazil

Kluyveromyces fragilis Brazil, USA (GRAS Notice GRN No. 88)

Saccharomyces carlsbergensis Brazil

Saccharomyces cerevisiae Mexico, Brazil, Australia, New Zealand, Canada, Denmark, France, USA (GRAS Notice GRN No. 88), JECFA

Protaminobacter rubrum Brazil EC Isoamylase Pseudomonas amyloderamosa GRN No. 85 3.2.1.68 EC Laccase Myceliphthora thermophila Brazil, USA (GRAS Notice GRN 1.10.3.2 expressed in Aspergillus oryzae No.122) EC Lactase Bacillus subtilis Denmark, France 3.2.1.23 Aspergillus niger Brazil, Mexico, Denmark

Aspergillus oryzae Australia, New Zealand, Brazil, Mexico, Denmark, France

Aspergillus oryzae expressed in Brazil, USA (GRAS Notice GRN No. Aspergillus niger 510)

Candida pseudotropicalis Brazil, USA (21 CFR 184.1387)

Kluyveromyces fragilis Brazil

Kluyveromyces lactis Australia, New Zealand, Canada, Denmark, France, Japan, Brazil, USA (21 CFR 184.1388)

Kluyveromyces marxianus Brazil, USA (GRAS Notice GRN No. 88)

Saccharomyces sp Brazil

Bifidobacterium bifidum Australia, New Zealand, Brazil, expressed in Bacillus Denmark, France, USA (GRAS licheniformis Notice GRN No. 572), Canada, Mexico

Kluyveromyces fragilis (Kluyveromycesmarxianus var. marxian us)

Kluyveromyces lactis expressed Australia, China in Kluyveromyces lactis

Bifidobacterium bifidum USA (GRN 579), France, Denmark expressed in Bacillus subtilis

Lactase from Bacillus subtilis Canada CB108 EC Leucine Lactococcus lactis USA GRAS 3445, Brazil, Australia, 3.4.11.1 aminopeptidase New Zealand, Canada EC Lipase Penicillium camembertii USA (GRAS Notice GRN No. 68, 3.1.1.23 (acylglycerol) 274) EC 3.1.1.3 Lipase Aspergillus niger Brazil, Australia, New Zealand, Mexico, Denmark, France, Canada, USA (GRAS Notice GRN No. 111), JECFA.

Aspergillus oryzae Brazil, Australia, New Zealand, Denmark, France, Mexico, JECFA

Brevibacterium lineus Brazil

Candida antarctica expressed in Brazil, USA (GRAS Notice GRN No. Aspergillus niger 158), Canada, China, Denmark, France

Candida lipolytica Brazil

Candida rugose (Candida Brazil, USA (GRAS Notice GRN No. cylindracea) 81), Australia, New Zealand, Canada

Fusarium culmorum expressed Brazil, Canada, USA (GRAS Notice in Aspergillus niger GRN No. 296)

Fusarium heterosporum Brazil, USA (GRAS Notice GRN No. expressed in Hansenula 238) polymorpha (Pichia angusta)

Hansenula polymorpha Australia, New Zealand, Denmark, France

Fusarium oxysporum expressed Brazil, Australia, New Zealand, USA in Aspergillus oryzae (GRAS Notice GRN No. 75), Canada, China, Denmark, France, Mexico

Fusarium oxysporum expressed Brazil (GRAS Notice GRN No. 631 in T. reesei

Humicola lanuginosa expressed Brazil, USA (GRAS Notice GRN No. in Aspergillus oryzae 43), Australia, New Zealand, Canada, China, Denmark, France, Mexico

Mucor javanicus Australia, New Zealand, Canada, Brazil

Mucor pusillus Brazil

Mucor circinelloides f Australia, New Zealand, Canada circinelloides

Penicillium camembertii Brazil, Australia, New Zealand, Canada

Penicillium roquefortii Australia, New Zealand

Rhizomucor miehei Australia, New Zealand, Brazil, Canada, Denmark, Japan

Rhizopusar rhizus Australia, New Zealand, Brazil

Rhizopus delemar Brazil

Rhizopus oryzae Australia, New Zealand, Canada, France, Japan, Mexico, USA (GRAS Notice GRN No. 216)

Rhizomucor miehei expressed Brazil, Australia, New Zealand, in Aspergillus oryzae Canada, China, Denmark, Mexico

Rhizopus nigrican Brazil

Rhizopus niveus Brazil, Australia, New Zealand, Mexico, USA (21 CFR 184.1420)

Thermomyces lanuginosus Brazil, Mexico, USA (GRAS Notice expressed in Aspergillus oryzae No. GRN No. 103)

Thermomyces lanuginosus and Brazil, USA (GRAS Notice GRN No. Fusarium oxysporum expressed 75, 103), Denmark, Canada in Aspergillus oryzae

Kluyveromyces lactis UK, France, Greece, Iceland, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Sweden, Poland, Turkey, Ukraine, Puerto Rico

Fusarium culmorum expressed Australia, Brazil in Aspergillus niger

Aspergillus tubingensis expressed in Trichoderma reesei

Fusarium oxysporum expressed France, Canada, USA GRAS #631, in T. reesei Mexico, China

Pseudomonas fluorescens USA (GRAS Notice GRN No. 462)

Edible tissue of calves, kids or lambs, or animal pancreatic USA (21 CFR 184.1415) tissue EC 3.1.1.5 Lysophospholipase Aspergillus niger expressed in Brazil, Australia, New Zealand, Aspergillus niger Denmark, France Japón, Mexico

A. nishimurae (ex fumigatus) USA (GRAS Notice GRN No. 653) expressed in T. reesei

A. nishimurae (ex fumigatus) expressed in T. reesei France, GRAS USA #653 EC Lysozyme Chicken egg white USA (GRAS Notice GRN No. 64) 3.2.1.17 EC Maltase and alpha- Aspergillus niger Brazil, USA (GRAS Notice No. GRN 3.2.1.20 glucosidase 89), Australia, New Zealand, Denmark, France, Mexico, Japan

Aspergillus oryzae Brazil

Rhizopus oryzae Brazil, JECFA, Mexico, USA (21 CFR 173.130)

Trichoderma reesei Brazil, USA (GRAS Notice GRN No. 703)

Aspergillus niger expressed in USA (GRAS Notice No. GRN 703) Trichoderma reesei EC Maltotetraohydrola Pseudomonas stutzeri Brazil, USA (GRN 277) 3.2.1.60 se expressed in Bacillus lichemformis EC Mannanase Aspergillus niger Australia/New Zealand, GRAS GRN 3.2.1.78 89, 566

Trichoderma reesei USA (GRAS GRN No. 566)

Talaromyces leycettanus USA GRN 739 expressed in Aspergillus niger

Mannanase from Aspergillus niger AE-HCM Canada 3.2.1.78 Mannan endo-1,4- T. reesei expressed in T. reesei Australia, USA GRAS #566 β-mannosidase

EC 3.2.1.1 Mixed microbial Bacillus subtilis JECFA, Australia, New Zealand, EC carbohydrase and USA (21 CFR 184.1148) 3.4.21.14 protease EC Bacillus licheniformis USA (21 CFR 184.1027) 3.4.24.4 Aspergillus oryzae USA (GRN No. 90) 3.4.24.28 Bacillolysin, B. subtilis France, Australia, Canada, USA, Neutral protease China, Mexico, Brazil (Metalloendopeptid ase) Nitrate reductase Micrococcus violagabriella Brazil EC Pancreatin Porcine or bovine pancreatic USA (21 CFR 184.1583) 3.4.21.36 tissue Papain Carica papaya L. Crude USA (21 CFR 184.1585) EC Pectin esterase Aspergillus aculeatus expressed Australia, Brazil, Canada, China, 3.1.1.11 in Aspergillus oryzae Denmark, France, Mexico, USA (GRAS Notice GRN No. 8)

Aspergillus aculeatus or Aspergillus niger expressed in Mexico, Brazil, USA Aspergillus oryzae

Aspergillus niger Australia, New Zealand, Denmark,France, Brazil, Mexico, Canada, JECFA, USA (GRAS Notice GRN No. 89)

Aspergillus niger expressed in Brazil, Australia, China, Denmark, Aspergillus niger Mexico

A. niger (A. tubigiensis) France, Australia, GRAS 558, expressed in T. reesei Canada EC Pectinalyase Aspergillus aculeatus or Brazil, Denmark 4.2.2.10 Aspergillus niger expressed in Aspergillus niger

Aspergillus niger Brazil, Australia, New Zealand, Denmark, France, Mexico, USA (GRAS Notice GRN No. 89)

Aspergillus niger expressed in Brazil, USA (GRAS Notice GRN No. Trichoderma reesei 32)

Aspergillus niger expressed in Australia, Brazil, China, Denmark, Aspergillus niger Mexico EC Pectate Bacillus subtilis USA (GRN 114), Japan 4.2.2.2. EC Pectinase Aspergillus awamori Brazil 3.2.1.15 (Polygalacturonase Aspergillus foetidus Brazil ) Aspergillus niger Australia, New Zealand, Brazil, Denmark, France, Mexico, Canada, JECFA, USA (GRAS Notice GRN No. 89)

Aspergillus oryzae Brazil, Australia, New Zealand

Penicillium simplicissium Brazil

Rhizopus oryzae Brazil

Trichoderma reesei Brazil, Australia, New Zealand, USA (GRAS Notice GRAS GRN No. 32, 557) Aspergillus niger Brazil, USA (GRAS Notice GRN No. 89)

Aspergillus niger expressed in Brazil Aspergillus niger

Aspergillus aculeatus China, Singapore, Canada, Denmark, France, Mexico EC Glandular layer of pork stomach USA 21 CFR 185.1595 3.4.23.1 EC Peroxidase Marasmius scorodonius Canada, USA GRAS GRN 402) 1.11.1.7 expressed in Aspergillus niger EC Protease Trichoderma reesei expressed Denmark, USA (GRN 333) 3.4.32.36 in Trichoderma reesei EC Protease Aspergillus niger Brazil, JECFA, Australia, USA 3.4.23.18 (GRN 89) 3.4.21.111 Protease Thermus aquaticus expressed in AUS; CAN (Aqualysin) Bacillus subtilis

EC Protease Aspergillus oryzae Brazil, Australia, New Zealand, 3.4.21.63 (Aspergillopepsin I) JECFA, USA (GRAS Notice GRN EC 3.4. No. 90) 23.18 EC 3.4.21.14 EC 3.4.23.6 EC Trichoderma reesei expressed USA (GRAS Notice GRN No. 333) 3.4.23.18 in Trichoderma reesei EC Aspergillus niger USA (GRAS Notice GRN No. 89) 3.4.23.6 EC Protease Bacillus amyloliquefaciens Denmark, France, Mexico, USA (21 3.4.24.28 (bacillolysin) expressed in Bacillus CFR 184.1150), Australia, New amyloliquefaciens Zealand, Canada, Japan

EC Proteasa Bacillus amyloliquefaciens Australia/New Zealand, Brazil, 3.4.24.28 (Bacillolysin) Canada, China, Denmark, France, Singapore, Mexico, USA (21 CFR 184.1150)

Bacillus subtilis USA (21 CFR 184.1150) EC Protease Geobacillus caldoproteolyticus USA (GRAS Notice GRN No. 598), 3.4.24.27 (Thermolysin) Denmark, France

EC Serine protease Bacillus subtilis Brazil, Australia, New Zealand 3.4.21.14 EC 3.4.11 Protease Aspergillus melleus Brazil

EC Protease Aspergillus niger Brazil, Australia, New Zealand, 3.4.21.26 Canada, Japan, USA (GRN No. 89)

EC 3.4.23 Protease Aspergillus niger expressed in Brazil Aspergillus niger

Aspergillus oryzae Brazil, USA (GRN No. 90)

EC Protease Bacillus amyloliquefaciens Brazil, USA (21 CFR 184.1150). 3.4.24.28 Australia, New Zealand EC 3.4.21.14 EC Protease Bacillus amyloliquefaciens Brazil 3.4.24.28 expressed in Bacillus subtilis

Bacillus cereus Brazil

EC Protease Bacillus licheniformis Brazil, Australia, New Zealand, 3.4.21.62 Denmark, France, Mexico, Canada, EC USA (21 CFR 184.1027) 3.4.21.14 EC Protease Bacillus subtilis Brazil, USA (21 CFR 184.1150), 3.4.24.28 JECFA

Endothia parasitica Brazil

EC Protease Fusarium oxysporum expressed Brazil, USA (GRAS Notice GRN No. 3.4.21.4 in Fusarium venenatun 563), JECFA, Australia, New Zealand, Denmark, France, Mexico, Canada

Lactobacillus casei Brazil

Micrococcus caseolyticus Brazil

Mucor pusillus Brazil

Nocardiopsis prasina expressed Brazil, Australia, Canada, Denmark, in Bacillus licheniformis France, JECFA, Mexico, USA (GRN 564) EC Protease Rhizomucor miehei Brazil, Australia, New Zealand, 3.4.23.23 Canada, Denmark EC Protease Rhizomucor miehei expressed Brazil, USA (Gras Notice GRN No. 3.4.23.23 in Aspergillus oryzae 34)

Streptomyces fradiae Brazil EC Pullulanase Bacillus acidopullulyticus Brazil, Mexico, Australia, New 3.2.1.41 Zealand, Canada, France, Denmark

Bacillus acidopullulyticus Brazil, USA (GRAS Notice GRN No. expressed in Bacillus subtilis 205), Australia, China, Denmark, France, Mexico

Bacillus deramificans expressed Brazil, Mexico, Canada, France, in Bacillus licheniformis USA (GRAS Notice No. 72, 645)

Bacillus deramificans expressed Brazil, Canada, China, Denmark, in Bacillus subtilis France, Mexico

Bacillus naganoensis expressed Brazil, Canada, Australia, New in Bacillus subtilis Zealand

Bacillus subtilis Brazil, Mexico, Australia, New Zealand, Denmark, France

Klebsiella aerogenes Brazil, Mexico, JECFA

Klebsiella pneumonia Brazil

Bacillus licheniformis Brazil, JECFA

Bacillus deramificans expressed JECFA, Brazil, USA (GRN 72) in Bacillus licheniformis EC Chymosin A derived from Brazil 3.4.23.4 Escherichia coli K-12 containing a gene from proChymosin A

Chymosin B derived from Brazil, USA 21 CFR 184.1685 Aspergillus niger var. awamori containing a gene from proChymosin B

Chymosin B derived from Brazil Kluyveromyces lactis containing a gene from proChymosin B

Aspergillus niger var. awamori USA 21 CFR 184.1685

Escherichia coli K-12 containing USA 21 CFR 184.1685 a gene of Prochymosin A

Chymosin B derived from USA (GRN 230) Trichoderma reesei containing a gene from proChymosin B

Chymosin B derived from Cartamus tinctorius containing a gene from proChymosin B EC Rennin Bacillus cereus Brazil, Mexico, JECFA, USA 21 3.4.23.23 CFR sec. 173.151, Canada

Endothia parasitica Brazil, Mexico, JECFA, USA 21 CFR sec. 173.151, Canada

Rhizomucor miehei Brazil, Mexico, JECFA, USA 21 CFR sec. 173.151, Canada

Rhizomucor pusillus Brazil, Mexico, JECFA, USA 21 CFR sec. 173.151, Canada Tannase Aspergillus niger Brazil, GRAS Notice No. GRN 000020 Aspergillus oryzae Brazil, France EC Transglucosidase Aspergillus niger expressed in USA (GRAS Notice No. GRN 315) 2.4.1.24 Trichoderma reesei EC Transglutaminase Streptoverticillium mobaraense Brazil, Canada, USA (GRAS Notice 2.3.2.13 var. S-8112 GRN No. 95, 55, 29, 04), Australia, New Zealand, France, Japan

EC Trehalase Trichoderma reesei expressed France, Denmark, USA (GRAS 3.2.1.28 in Trichoderma reesei Notice No. GRN 727)

Myceliophthora sepedonium USA (GRAS Notice No. GRN 699) expressed in Aspergillus niger

Gloeophyllum sepiarium, Myceliophthora sepedonium expressed in Aspergillus niger USA (GRN 699) EC Trypsin Fusarium oxysporum expressed USA (GRAS Notice GRN No. 563) 3.4.21.4 in Fusarium venenatum

Fusarium venenatum JECFA, Australia, New Zealand, Denmark, France, Mexico, Canada

Purified extracts of porcine or USA (21 CFR 184.1914) bovine pancreas EC 3.5.1.5 Urease Lactobacillus fermentum USA (21 CFR 184.1924) EC 3.2.1.8 Endo-1,4-beta- Aspergillus aculeatus expressed Australia/New Zealand, Brazil, xylanase in Aspergillus oryzae China, Denmark, France, Mexico

Aspergillus aculeatus or Aspergillus niger expressed in Brazil Aspergillus oryzae

Aspergillus niger Brazil, France, USA (GRAS Notice GRN No. 89)

Aspergillus niger expressed in Brazil, Australia Aspergillus niger

Bacillus licheniformis expressed Brazil, Canada, Denmark, France, in Bacillus licheniformis Mexico, USA (GRAS Notice GRN No. 472) Bacillus subtilis expressed in Brazil Bacillus subtilis

Humicola insolens Brazil, USA (GRAS Notice GRN No. 195), Australia/New Zealand, China, Denmark, France, Mexico

Pseudoalteromonas haloplanktis Australia, Brazil, Canada expressed in Bacillus subtillis

Disporotrichum JECFA, Canada, China, France, dimorphosporum USA (GRN 482), Singapore

Thermomyces lanuginosus Brazil, Australia/New Zealand, expressed in Aspergillus oryzae Canada, Denmark, France, Mexico

Thermomyces lanuginosus Brazil, USA (GRAS Notice GRN No. expressed in Fusarium 54) venenatum

Trichoderma reesei Australia, New Zealand, Brazil

Talaromyces leycettanus Denmark, Mexico, USA (GRAS expressed in Trichoderma Notice GRN No. 675) reesei

Aspergillus niger var. Tubigensis Brazil, Denmark, USA (GRAS expressed in Trichoderma Notice GRN 567) reesei

N. flexuosa expressed in USA (GRAS Notice GRN No. 628) Trichoderma reesei

Rasamsonia (Talaromyces) Denmark, France USA (GRAS GRN emersonii expressed in 589) Aspergillus niger

Trichoderma reesei Australia, New Zealand, Canada, (longibrachiatum) France, JECFA, Denmark, Japan

Rasamsonia (Talaromyces) Australia, New Zealand, USA emersonii (GRAS GRN 479)

A. niger (A. acidus, ex. A. foetidus var. acidus expressed France, Denmark, Australia, USA, in A. niger (A. acidus, ex. A. Canada, China, Mexico, Brazil foetidus var. acidus)

Nonomuraea flexuosa France, Australia, USA GRAS #628 expressed in T. reesei

Aspergillus luchuensis

Trichoderma citrinoviride

Enzymes of animal origin enzima Source(s) Alpha-amylase Swine and bovine pancreas Catalase Liver of horse or bovine Chymosin Calves and goats abomasum Lactoperoxidase Bovine milk Lipase Abomasum and salivary gland of bovine, swine, goat, and ovine Bovine stomach Swine and bovine pancreas Pregastric bovine (calf) tissue Pregastric ovine (lamb) tissue Lysozyme Egg white Bovine pepsin Abomasum (4th part of the stomach) Swine pepsin Red mucosa (as gastric mucosa) Bird pepsin Proventicum of poultry Phospholipase A2 Swine pancreas Phospholipase A2 Swine pancreas expressed in Aspergillus niger Pancreatin Swine and bovine pancreas – rennet complex Abomasum of ruminants Trypsin or chymotrypsin Swine and bovine pancreas

Enzymes of plant origin Enzima Source(s) Alpha- Malt, malted cereals and leguminous amylase Beta-amylase Malt, malted cereals and leguminous Bromelain Stem, leaves and fruits of Bromeliaceae (Ananas sativus and Ananas comosus) Vegetable Thistle Cynara cardunculus coagulases Fig Ficus carica Ficcin Stems, leaves and fruits of Ficus family (Ficus glabrata and Ficus carica) Lipoxygenase Soy flour Papain Stem, leaves and fruits of plants of Carica family (Carica papaya and Ananas bracteatus) Peroxidase Horseradish, soybean flour, wheat flour Protease Carica Papaya Protease Ananas sp