W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 7-2012 Transcriptional Regulation of the Acetone Carboxylase Operon via Two-Component Signal Transduction in Helicobacter pylori Samuel Emerson Harvey College of William and Mary Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the Biology Commons Recommended Citation Harvey, Samuel Emerson, "Transcriptional Regulation of the Acetone Carboxylase Operon via Two- Component Signal Transduction in Helicobacter pylori" (2012). Undergraduate Honors Theses. Paper 471. https://scholarworks.wm.edu/honorstheses/471 This Honors Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact
[email protected]. Transcriptional Regulation of the Acetone Carboxylase Operon via Two- Component Signal Transduction in Helicobacter pylori A thesis submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Biology from The College of William & Mary By Samuel Emerson Harvey Accepted for ____________________________ (Honors) _______________________________________ Dr. Mark Forsyth, Chair _______________________________________ Dr. Oliver Kerscher _______________________________________ Dr. Kurt Williamson _______________________________________ Dr. Randolph Coleman Williamsburg, VA April 30, 2012 Abstract Helicobacter pylori is a gram negative gastric pathogen that infects the mucosal lining of the human stomach and is present is nearly half of the human population. H. pylori is the etiologic agent of peptic ulcer disease, and infection is highly associated with the development of gastric cancer. The H. pylori genome encodes three complete two- component signal transduction systems (TCSTs): ArsRS, CrdRS, and FlgRS.