gazetteer

Metabolism 35 tRNA modification mitochondrial transport amino-acid metabolism other tRNA-transcription activities vesicular transport (Golgi network, etc.) nitrogen and sulphur metabolism mRNA synthesis peroxisomal transport nucleotide metabolism mRNA processing (splicing) vacuolar transport phosphate metabolism mRNA processing (5’-end, 3’-end processing extracellular transport carbohydrate metabolism and mRNA degradation) cellular import lipid, fatty-acid and sterol metabolism other mRNA-transcription activities other intracellular-transport activities biosynthesis of vitamins, cofactors and RNA transport prosthetic groups other transcription activities Cellular organization and biogenesis 54 ionic homeostasis organization and biogenesis of cell wall and Protein synthesis 48 plasma membrane Energy 40 ribosomal proteins organization and biogenesis of glycolysis translation (initiation,elongation and cytoskeleton gluconeogenesis termination) organization and biogenesis of endoplasmic pentose-phosphate pathway translational control reticulum and Golgi tricarboxylic-acid pathway tRNA synthetases organization and biogenesis of chromosome respiration other protein-synthesis activities structure fermentation mitochondrial organization and biogenesis metabolism of energy reserves (glycogen Protein destination 49 peroxisomal organization and biogenesis and trehalose) protein folding and stabilization endosomal organization and biogenesis other energy-generation activities protein targeting, sorting and translocation vacuolar and lysosomal organization and protein modification (glycosylation, acylation, biogenesis Cell growth, cell division and DNA myristylation, palmitylation, farnesylation other cellular organization and biogenesis synthesis 41 and processing) activities cell growth assembly of protein complexes budding, cell polarity and filament formation proteolysis Signal transduction 58 pheromone response and mating-type other protein-destination activities pheromone response generation determination morphogenesis sporulation and germination Transport facilitation 51 osmosensing meiosis ion channels nutritional response DNA synthesis and replication ion transporters other signal-transduction activities recombination and DNA repair sugar and carbohydrate transporters cell-cycle control and mitosis amino-acid transporters Cell rescue 59 cytokinesis lipid transporters stress response generation other cell-growth, cell-division and DNA- purine and pyrimidine transporters DNA repair (direct repair, base excision synthesis activities allantoin and allantoate transporters repair and nucleotide excision repair) transport ATPases detoxificaton Transcription 45 ABC transporters cell death and ageing rRNA synthesis drug transporters degradation of exogenous polynucleotides rRNA processing other transport-facilitators other cell-rescue activities other rRNA-transcription activities tRNA synthesis Intracellular transport 53 Unclassified proteins 60 tRNA processing nuclear transport

YBR084w MIS1 C1-tetrahydrofolate synthase, YCL009c similarity to acetolactate synthase III small mitochondrial subunit Metabolism YPR060c ARO7 chorismate mutase YLR089c similarity to alanine transaminases YGL148w ARO2 chorismate synthase YGL184c similarity to cystathionine β-lyase amino-acid metabolism YGR155w CYS4 cystathionine β-synthase YHR112c similarity to cystathionine γ-synthases YAL012w CYS3 cystathionine γ-lyase YIL074c similarity to E. coli phosphoglycerate amino-acid biosynthesis YER023w PRO3 δ 1-pyrroline-5-carboxylate reductase dehydrogenase YHR068w DYS1 deoxyhypusine synthase YGR012w similarity to E. nidulans cysteine synthase [ORF] [Gene] [Encoded or related protein] YOR236w DFR1 dihydrofolate reductase YMR250w similarity to glutamate decarboxylases YHR037w PUT2 1-pyrroline-5-carboxylate dehydrogenase YFL018c LPD1 dihydrolipoamide dehydrogenase YMR062c similarity to glutamate N-acetyltransferase YDR035w ARO3 2-dehydro-3-deoxyphosphoheptonate YJR016c ILV3 dihydroxy-acid dehydratase YDL131w similarity to homocitrate synthases and aldolase, phenylalanine-inhibited YLR172c DPH5 diphthamide methyltransferase isopropylmalate synthases YBR249c ARO4 2-dehydro-3-deoxyphosphoheptonate YKL191w DPH2 diphtheria toxin resistance protein YIL094c similarity to isopropyl malate and tartrate aldolase, tyrosine-inhibited YOR323c PRO2 γ-glutamyl phosphate reductase dehydrogenases YNL104c LEU4 2-isopropylmalalate synthase YDR300c PRO1 glutamate 5-kinase YEL038w UTR4 similarity to K. oxytoca enolase- YGL009c LEU1 3-isopropylmalate dehydratase YDL171c GLT1 glutamate synthase (NAPDPH) (GOGAT) phosphatase E-1 YPR167c MET16 3’-phosphoadenylylsulphate reductase YPR035w GLN1 glutamate-ammonia ligase YML082w similarity to N. crassa YGR019w UGA1 4-aminobutyrate aminotransferase (GABA YBR248c HIS7 glutamine amidotransferase/cyclase O-succinylhomoserine (thiol)-lyase transaminase) YFR025c HIS2 histidinol phosphatase YJR130c similarity to O-succinylhomoserine YER091c MET6 5-methyltetrahydropteroyltriglutamate- YIL116w HIS5 histidinol-phosphate aminotransferase (thiol)-lyase homocysteine methyltransferase YMR038c LYS7 homocitrate dehydrogenase YKL215c similarity to P. aeruginosa hyuA and hyuB YMR108w ILV2 acetolactate synthase YDL182w LYS20 homocitrate synthase YOR280c similarity to S. pombe dihydrofolate YCL009c ILV6 acetolactate synthase, regulatory subunit YJR139c HOM6 homoserine dehydrogenase reductase YER069w ARG5,6 acetylglutamate kinase and YHR025w THR1 homoserine kinase YFL030w similarity to several transaminases acetylglutamyl-phosphate reductase YNL277w MET2 homoserine O-acetyltransferase YOR108w strong similarity to 2-isopropylmalate YJL071w ARG2 acetylglutamate synthase YOR202w HIS3 imidazoleglycerol-phosphate dehydratase synthase YOL140w ARG8 acetylornithine aminotransferase YLR355c ILV5 ketol-acid reducto-isomerase YAL004w strong similarity to A. klebsiana glutamate YDR234w LYS4 aconitate hydratase YBR115c LYS2 L-aminoadipate-semialdehyde dehydrogenase YER086w ILV1 anabolic serine and threonine dehydrogenase, large subunit YDR111c strong similarity to alanine transaminase dehydratase YGL154c LYS5 L-aminoadipate-semialdehyde YFR055w strong similarity to β-cystathionases YDR354w TRP4 anthranilate phosphoribosyltransferase dehydrogenase, small subunit YHR033w strong similarity to glutamate 5-kinase YER090w TRP2 anthranilate synthase component I YER052c HOM3 L-aspartate 4-P-transferase YHR070w strong similarity to N. crassa met-10+ YKL211c TRP3 anthranilate synthase component II YLR303w MET25 O-acetylhomoserine sulphydrylase protein YJR109c CPA2 arginine-specific carbamoylphosphate YLR438w CAR2 ornithine aminotransferase YLL058w strong similarity to N. crassa synthase, large subunit YJL088w ARG3 ornithine carbamoyltransferase O-succinylhomoserine (thiol)-lyase YOR303w CPA1 arginine-specific carbamoylphosphate YCL030c HIS4 phosphoribosyl-AMP YER081w strong similarity to phosphoglycerate synthase, small subunit cyclohydrolase/phosphoribosyl-ATP dehydrogenases YOL058w ARG1 argininosuccinate synthetase pyrophosphatase/histidinol YJR010w MET3 sulphate adenylyltransferase YHR018c ARG4 arginosuccinate lyase dehydrogenase YCR053w THR4 threonine synthase (o-p-homoserine YDR127w ARO1 arom pentafunctional enzyme YDR007w TRP1 phosphoribosylanthranilate isomerase p-lyase) YPR145w ASN1 asparagine synthetase YGR208w SER2 phosphoserine phosphatase YPR074c TKL1 transketolase 1 YGR124w ASN2 asparagine synthetase YOR184w SER1 phosphoserine transaminase YBR117c TKL2 transketolase 2 YLR027c AAT2 aspartate aminotransferase, cytosolic YNL316c PHA2 prephenate dehydratase YGL026c TRP5 tryptophan synthase YKL106w AAT1 aspartate transaminase, mitochondrial YBR166c TYR1 prephenate dehydrogenase (NADP+) YML096w weak similarity to asparagine synthases YDR158w HOM2 aspartate-semialdehyde dehydrogenase YLR142w PUT1 proline oxidase YFR030w MET10 assimilatory sulphite reductase flavin- YOL064c MET22 protein ser/thr phosphatase regulation of amino-acid metabolism binding subunit YCR054c CTR86 putative threonine biosynthesis pathway YDR173c ARG82 arginine metabolism transcription factor YER055c HIS1 ATP phosphoribosyltransferase protein YKL112w ABF1 ARS-binding factor YCL018w LEU2 β-isopropyl-malate dehydrogenase YEL046c GLY1 required for glycine prototrophy in SHMT1 YER055c HIS1 ATP phosphoribosyltransferase YJR148w TWT2 branched-chain amino acid and SHMT2 double mutant YBR253w SRB6 DNA-directed RNA polymerase II aminotransferase, cytosolic YIR034c LYS1 saccharopine dehydrogenase suppressor protein YHR208w TWT1 branched-chain amino acid YNR050c LYS9 saccharopine dehydrogenase (NADP+, L- YNL236w SIN4 global regulator protein aminotransferase, mitochondrial glutamate forming) YGR204w ADE3 C1-tetrahydrofolate synthase, cytoplasmic

NATURE | VOL 387 | SUPP | 29 MAY 1997 35 gazetteer

YFL010w-a AUA1 involved in ammonia regulation of amino- other amino-acid metabolism activities nucleotide metabolism acid transport YKL157w APE2 aminopeptidase yscII YIL046w MET30 involved in regulation of sulphur YGL017w ATE1 arginyl tRNA transferase purine-ribonucleotide metabolism assimilation genes YPR069c SPE3 putrescine aminopropyltransferase YLR028c ADE16 5-aminoimidazole-4-carboxamide ribotide YJR060w CBF1 kinetochore protein (spermidine synthase) transformylase YDR159w SAC3 leucine permease transcriptional regulator YFR018c similarity to human glutaminyl-peptide YGR061c ADE6 5’-phosphoribosylformyl glycinamidine YDR207c UME6 negative transcriptional regulator cyclotransferase synthetase YKL015w PUT3 positive activator of the proline utilisation YML022w APT1 adenine phosphoribosyltransferase pathway nitrogen and sulphur metabolism YDR441c APT2 adenine phosphoribosyltransferase YCR028c FEN2 similarity to allantoate permease YNL220w ADE12 adenylosuccinate synthetase transporter nitrogen and sulphur utilization YIR027c DAL1 allantoinase YMR116c strong similarity to N. crassa CPC2 YPR167c MET16 3’-phosphoadenylylsulphate reductase YIR029w DAL2 allantoinase protein YIR027c DAL1 allantoinase YMR300c ADE4 amidophosphoribosyltransferase YKR099w BAS1 transcription factor YIR029w DAL2 allantoinase YML035c AMD1 AMP deaminase YLR098c CHA4 transcription factor YDR242w AMD2 amidase YGR204w ADE3 C1-tetrahydrofolate synthase, cytoplasmic YLR451w LEU3 transcription factor YOL058w ARG1 argininosuccinate synthetase YBR084w MIS1 C1-tetrahydrofolate synthase, YMR042w ARG80 transcription factor involved in arginine YLR027c AAT2 aspartate aminotransferase, cytosolic mitochondrial metabolism YFR030w MET10 assimilatory sulphite reductase flavin- YOR236w DFR1 dihydrofolate reductase YML099c ARG81 transcription factor involved in arginine binding subunit YMR217w GUA1 GMP synthase (glutamine-hydrolyzing) metabolism YKL001c MET14 ATP adenosine-5’-phosphosulphate YHR216w PUR5 IMP dehydrogenase YMR043w MCM1 transcription factor of the MADS box 3’-phosphotransferase YIR031c DAL7 malate synthase 2 family YHR176w FMO flavin-containing monooxygenase YKR080w MTD1 methylenetetrahydrofolate dehydrogenase YIR023w DAL81 transcriptional activator for allantoin and YOR375c GDH1 glutamate dehydrogenase (NADP+) (NAD+) GABA catabolic genes YDL171c GLT1 glutamate synthase (NAPDPH) (GOGAT) YAR015w ADE1 phosphoribosylamidoimidazole- YEL009c GCN4 transcriptional activator of amino acid YPR035w GLN1 glutamate-ammonia ligase succinocarboxamide synthase biosynthetic genes YJL172w CPS1 Gly-X carboxypeptidase YSCS YGL234w ADE5,7 phosphoribosylamine-glycine ligase and YDR034c LYS14 transcriptional activator of lysine pathway YAL062w GDH3 NADP-glutamate dehydrogenase phosphoribosylformylglycinamidine genes YDL215c GDH2 NAD-specific glutamate dehydrogenase cyclo-ligase YIR017c MET28 transcriptional activator of sulphur amino (NAD) YOR128c ADE2 phosphoribosylaminoimidazole acid metabolism YLR438w CAR2 ornithine aminotransferase carboxylase YNL103w MET4 transcriptional activator of sulphur YJR149w similarity to 2-nitropropane dioxygenase YDR408c ADE8 phosphoribosylglycinamide metabolism YLR089c similarity to alanine transaminases formyltransferase (GART) YMR293c similarity to amidases YKL181w PRPS1 ribose-phosphate pyrophosphokinase amino-acid transport YFL061w similarity to M. verrucaria cyanamide YER099c PRS2 ribose-phosphate pyrophosphokinase YBR068c BAP2 amino-acid permease hydratase YHL011c PRS3 ribose-phosphate pyrophosphokinase YEL063c CAN1 amino-acid permease YFL030w similarity to several transaminases YBL068w PRS4 ribose-phosphate pyrophosphokinase YBR069c VAP1 amino-acid permease YOR251c similarity to thiosulphate YLR058c SHM2 serine hydroxymethyltransferase, YCL025c AGP1 asparagine and glutamine permease sulphurtransferases cytoplasmic YPL265w DIP5 dicarboxylic amino-acid permease YDR111c strong similarity to alanine transaminase YBR263w SHM1 serine hydroxymethyltransferase, YKR039w GAP1 general amino-acid permease YER057c strong similarity to Azotobacter nitrogen mitochondrial YDR508c GNP1 high-affinity glutamine permease fixation vnfA protein YNL141w similarity to adenosine deaminase YGR055w MUP1 high-affinity methionine permease YIL051c strong similarity to Azotobacter nitrogen YBR284w similarity to AMP deaminase YNL270c ALP1 high-affinity permease for basic amino fixation vnfA protein YJL070c similarity to AMP deaminases acids YJL060w strong similarity to kynurenine YLR017w similarity to human 5’- YOL020w SCM2 high-affinity tryptophan transport protein aminotransferase methylthioadenosine phosphorylase YGR191w HIP1 histidine permease YPL135w strong similarity to nitrogen fixation YOL061w similarity to ribose-phosphate YLR375w STP3 involved in pre-tRNA splicing and in protein (nifU) pyrophosphokinases uptake of branched-chain amino acids YOR226c strong similarity to nitrogen fixation YOR280c similarity to S. pombe dihydrofolate YDL048c STP4 involved in pre-tRNA splicing and in proteins reductase uptake of branched-chain amino acids YJR010w MET3 sulphate adenylyltransferase YDR020c similarity to uridine kinases and YNL268w LYP1 lysine-specific high affinity permease YJR137c sulphite reductase phosphoribulokinases YOR130c ARG11 member of the mitochondrial carrier YBR208c DUR1,2 urea amidolyase YLR359w strong similarity to adenylosuccinate family (MCF) YIR032c DAL3 ureidoglycolate hydrolase lyase YHL036w MUP3 methionine permease YJL035c weak similarity to B. japonicum nitrogen YMR120c strong similarity to chicken purH YOR348c PUT4 proline and γ-aminobutyrate permease fixation protein bifunctional enzyme YFL055w similarity to Gap1p and other amino-acid YKL040c weak similarity to nitrogen fixation protein YJR105w strong similarity to human adenosine permeases nifU kinase YDR160w similarity to lysine transport protein LYP1 YAR075w strong similarity to IMP dehydrogenases YLL061w strong similarity to amino-acid transport regulation of nitrogen and sulphur utilization YML056c strong similarity to IMP dehydrogenases protein Gap1p YGR019w UGA1 4-aminobutyrate aminotransferase (GABA YAR073w FUN63 strong similarity to IMP dehydrogenases YPL274w strong similarity to amino-acid transport transaminase) YLR432w strong similarity to IMP dehydrogenases, proteins YPL111w CAR1 arginase Pur5p and YML056c YDR046c (PAP1) strong similarity to amino-acid transport YKL112w ABF1 ARS-binding factor YLR209c strong similarity to purine-nucleoside proteins YNL216w RAP1 DNA-binding protein with repressor and phosphorylases YBR132c strong similarity to amino-acid permeases activator activity YBR208c DUR1,2 urea amidolyase YFL010w-a AUA1 involved in ammonia regulation of amino YIR032c DAL3 ureidoglycolate hydrolase amino-acid degradation acid transport YPL111w CAR1 arginase YIR030c DCG1 involved in nitrogen-catabolite metabolism pyrimidine-ribonucleotide metabolism YDR321w ASP1 asparaginase YBR213w MET8 involved in the expression of PAPS YBL039c URA7 CTP synthase 1 YOR375c GDH1 glutamate dehydrogenase (NADP+) reductase and sulphite reductase YJR103w URA8 CTP synthase 2 YMR189w GSD2 glycine decarboxylase subunit YDR207c UME6 negative transcriptional regulator YHR144c DCD1 deoxycytidylate deaminase YDR019c GCV1 glycine decarboxylase T subunit YNL229c URE2 nitrogen catabolite repression regulator YLR420w URA4 dihydroorotase YDR272w GLO2 glyoxalase II YEL062w NPR2 nitrogen permease regulator YKL216w URA1 dihydroorotate dehydrogenase YOR040w GLO4 glyoxalase II YNL183c NPR1 ser/thr protein kinase YJR057w CDC8 dTMP kinase YLR155c ASP3A L-asparaginase II YCR028c FEN2 similarity to allantoate permease YBR252w DUT1 dUTP pyrophosphatase, mitochondrial YLR157c ASP3B L-asparaginase II transporter YJL130c URA2 multifunctional pyrimidine biosynthesis YLR158c ASP3C L-asparaginase II YLR013w similarity to nitrogen regulatory proteins protein YLR160c ASP3D L-asparaginase II YGL254w FZF1 sulphite resistance protein YML106w URA5 orotate phosphoribosyltransferase 1 YCL064c CHA1 L-serine/L-threonine deaminase YFL021w GAT1 transcription factor for nitrogen regulation YMR271c URA10 orotate phosphoribosyltransferase 2 YAL062w GDH3 NADP-glutamate dehydrogenase YER040w GLN3 transcription factor for positive nitrogen YEL021w URA3 orotidine-5’-phosphate decarboxylase YDL215c GDH2 NAD-specific glutamate dehydrogenase regulation YFL058w THI5 pyrimidine biosynthesis protein (NAD) YMR042w ARG80 transcription factor involved in arginine YKL181w PRPS1 ribose-phosphate pyrophosphokinase YKL184w ORD1 ornithine decarboxylase metabolism YER099c PRS2 ribose-phosphate pyrophosphokinase YLR142w PUT1 proline oxidase YML099c ARG81 transcription factor involved in arginine YHL011c PRS3 ribose-phosphate pyrophosphokinase YLR180w SAM1 S-adenosylmethionine synthetase 1 metabolism YBL068w PRS4 ribose-phosphate pyrophosphokinase YDR502c SAM2 S-adenosylmethionine synthetase 2 YMR043w MCM1 transcription factor of the MADS box YOL061w similarity to ribose-phosphate YIL167w SDL1 serine dehydratase family pyrophosphokinases YDR294c similarity to glutamate decarboxylases YIR023w DAL81 transcriptional activator for allantoin and YOR280c similarity to S. pombe dihydrofolate YJR078w similarity to indoleamine 2,3-dioxygenase GABA catabolic genes reductase YIL042c similarity to rat branched-chain α-ketoacid YDL170w UGA3 transcriptional activator for GABA YLR245c strong similarity to B. subtilis cytidine dehydrogenase kinase catabolic genes deaminase YGL202w similarity to rat kynurenine/ YNL103w MET4 transcriptional activator of sulphur YNL332w strong similarity to Thi5p, YJR156c, α-aminoadipate aminotransferase metabolism YDL244w and A. parasiticus, S. pombe YHR137w similarity to rat kynurenine/ YKR034w DAL80 transcriptional repressor for allantoin and Nmt1p α-aminoadipate aminotransferase GABA catabolic genes YDL244w strong similarity to Thi5p, YJR156c, YFL030w similarity to several transaminases YNL332w and A. parasiticus, S. pombe YDR111c strong similarity to alanine transaminase nitrogen and sulphur transport nmt1 protein YBR006w strong similarity to E. coli succinate YGR121c MEP1 ammonia permease of high capacity and YJR156c THI11 thiamine regulated gene, homologous to semialdehyde dehydrogenase moderate affinity nmt1a in S. pombe YAL044c GCV3 strong similarity to human glycine YNL142w MEP2 high-affinity low-capacity ammonia YHR128w FUR1 uracil phosphoribosyltransferase cleavage system protein H permease YNR012w URK1 uridine kinase YIL168w SDL1 strong similarity to L-serine dehydratase YBR294w SUL1 high-affinity sulphate transport protein YKL024c URA6 uridine-monophosphate kinase Cha1p YPR003c similarity to sulphate transporter proteins YLR231c strong similarity to rat kynureninase YPR138c MEP3 strong similarity to ammonium transport deoxyribonucleotide metabolism YKL218c strong similarity to threonine dehydratase proteins YDR513w TTR1 glutaredoxin YBR208c DUR1,2 urea amidolyase YLR092w SEL2 strong similarity to Sul1p YER070w RNR1 ribonucleoside-diphosphate reductase, YHL016c DUR3 urea transport protein large subunit

36 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YJL026w RNR2 ribonucleoside-diphosphate reductase, YHR043c DOG2 2-deoxyglucose-6-phosphate YPR001w CIT3 citrate (si)-synthase, mitochondrial small subunit phosphatase YCR005c CIT2 citrate (si)-synthase, peroxisomal YGR180c RNR4 ribonucleotide reductase small subunit YMR282c AEP2 2’-O-ribosyl phosphate transferase YML086c ALO D-arabinino-1,4-lactone oxidase YIL066c RNR3 ribonucleotide reductase, repair inducible YBR092c PHO3 constitutive acid phosphatase YNL071w LAT1 dihydrolipoamide S-acetyltransferase large subunit YHR201c PPX1 exopolyphosphatase YDL174c DLD1 D-lactate ferricytochrome c YBR014c similarity to glutaredoxin YBR011c IPP1 inorganic pyrophosphatase, cytoplasmic oxidoreductase (D-LCR) YPL059w similarity to glutaredoxins YMR267w PPA2 inorganic pyrophosphatase, mitochondrial YER062c HOR2 DL-glycerol phosphatase YOR269w PAC1 similarity to human LIS-1 protein YBR093c PHO5 repressible acid phosphatase YIL053w RHR2 DL-glycerol phosphatase YDL010w similarity to hypothetical protein YBR014c YAR071w PHO11 secreted acid phosphatase YPL227c ALG5 dolichol-P-glucose synthetase and glutaredoxins YHR215w PHO12 secreted acid phosphatase YPR183w DPM1 dolichyl-phosphate β-D- YCL035c strong similarity to glutaredoxin YDL024c strong similarity to acid phosphatase mannosyltransferase YDR353w strong similarity to thioredoxin reductase YNL330c RPD3 transcription modifier protein YJR143c PMT4 dolichyl-phosphate-mannose-protein (NADPH) YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate O-mannosyl transferase YHR106w strong similarity to thioredoxin reductases transferase YOR095c RKI1 D-ribose-5-phosphate ketol-isomerase YOR074c CDC21 thymidylate synthase YJL121c POS18 D-ribulose-5-phosphate 3-epimerase regulation of phosphate utilization YGR282c BGL2 endo-1,3-—glucanase of the cell wall metabolism of cyclic and unusual nucleotides YOL001w PHO80 cyclin YLR286c CTS1 endochitinase YJL005w CYR1 adenylate cyclase YGR233c PHO81 cyclin-dependent kinase inhibitor YGR254w ENO1 enolase I (2-phosphoglycerate YCL050c APA1 ATP adenylyltransferase I YPL031c PHO85 cyclin-dependent protein kinase dehydratase) YDR530c APA2 ATP adenylyltransferase II YML121w GTR1 GTP-binding protein YHR174w ENO2 enolase II (2-phosphoglycerate YOL081w IRA2 GTPase-activating protein for RAS YDL106c GRF10 homeodomain protein dehydratase) proteins YBR106w PHO88 involved in phosphate transport YOR393w ERR1 enolase-related protein YOR360c PDE2 high affinity 3’,5’-cyclic-nucleotide YFR034c PHO4 transcription factor YPL281c ERR2 enolase-related protein phosphodiesterase YOR190w SPR1 exo-1,3-—glucanase YPL212c PUS1 pseudouridine synthase 1 phosphate transport YDR261c EXG2 exo-1,3-—glucanase minor isoform YGL063w PUS2 pseudouridine synthase 2 YLR348c dicarboxylate carrier protein YLR300w EXG1 exo-1,3-—glucanase(I/II), major isoform YML123c PHO84 high-affinity inorganic phosphate/H+ YIR019c STA1 extracellular α-1,4-glucan glucosidase regulation of nucleotide metabolism symporter YLR377c FBP1 fructose-1,6-bisphosphatase YOL081w IRA2 GTPase-activating protein for RAS YJL117w PHO86 inorganic phospate transporter YJL155c FBP26 fructose-2,6-bisphosphatase proteins YBR106w PHO88 involved in phosphate transport YKL060c FBA1 fructose-bisphosphate aldolase YOR101w RAS1 GTP-binding protein YCR037c PHO87 member of the phosphate permease YDL049c KNH1 functional homologue of Kre9p YNL098c RAS2 GTP-binding protein family YBR020w GAL1 galactokinase YDL106c GRF10 homeodomain protein YJR077c MIR1 phosphate transport protein, YDR009w GAL3 galactokinase YGL248w PDE1 low-affinity 3’,5’-cyclic-nucleotide mitochondrial (MCF) YOR120w GCY1 galactose-induced protein of aldo/keto phosphodiesterase YNR013c similarity to membrane protein Pho87p reductase family YNL076w MKS1 negative regulator of RAS-cAMP pathway and hypothetical protein YJL198w YPR159w KRE6 glucan synthase subunit YJL096w putative regulator of purine and/or YCR098c GIT1 similarity to phosphate transporter YGR143w SKN1 glucan synthase subunit pyrimidine biosynthesis proteins YKL104c GFA1 glucosamine-fructose-6-phosphate YOL110w SHR5 RAS suppressor YER053c strong similarity to mitochondrial transaminase YKR099w BAS1 transcription factor phosphate carrier protein YNL241c ZWF1 glucose-6-phosphate dehydrogenase YLR014c PPR1 transcription factor regulating pyrimidine YJL198w strong similarity to Pho87p YBR196c PGI1 glucose-6-phosphate isomerase pathway YBR296c strong similarity to phosphate-repressible YBR229c ROT2 glucosidase II, catalytic subunit YIR023w DAL81 transcriptional activator for allantoin and phosphate permease YOR002w ALG6 glucosyltransferase GABA catabolic genes YOR067c ALG8 glucosyltransferase YNL314w DAL82 transcriptional activator for allantoin other phosphate-metabolism activities YJL052w TDH1 glyceraldehyde-3-phosphate catabolic genes YDL236w PHO13 4-nitrophenylphosphatase dehydrogenase 1 YOR008c SLG1 weak similarity to L. mexicana lmsap2 YJR009c TDH2 glyceraldehyde-3-phosphate polynucleotide degradation gene dehydrogenase 2 YMR287c MSU1 3’-5’ exonuclease for RNA 3’ ss-tail, YGR192c TDH3 glyceraldehyde-3-phosphate mitochondrial carbohydrate metabolism dehydrogenase 3 YPL029w SUV3 ATP-dependent RNA helicase, YHL032c GUT1 glycerol kinase mitochondrial carbohydrate utilization YDL022w GPD1 glycerol-3-phosphate dehydrogenase YOR033c DHS1 exonuclease, interacting with Msh2p YLR342w FKS1 1,3-—D-glucan synthase, catalytic subunit (NAD+), cytoplasmic YKL149c DBR1 lariat-debranching enzyme YGR032w GSC2 1,3-—D-glucan synthase, subunit YOL059w GPD3 glycerol-3-phosphate dehydrogenase YGL173c KEM1 multifunctional nuclease YEL011w GLC3 1,4-glucan branching enzyme (glycogen (NAD+), mitochondrial YLR363c NMD4 Nam7p/Upf1p-interacting protein branching enzyme) YIL155c GUT2 glycerol-3-phosphate dehydrogenase, YJR132w NMD5 Nam7p/Upf1p-interacting protein YHR044c DOG1 2-deoxyglucose-6-phosphate mitochondrial YMR080c NAM7 nonsense-mediated mRNA decay protein phosphatase YPR160w GPH1 glycogen phosphorylase YGR072w UPF3 nonsense-mediated mRNA decay protein YHR043c DOG2 2-deoxyglucose-6-phosphate YFL014w HSP12 heat-shock protein YHR077c NMD2 nonsense-mediated mRNA decay protein phosphatase YFR053c HXK1 hexokinase I 2 YIL125w KGD1 2-oxoglutarate dehydrogenase complex YGL253w HXK2 hexokinase II YJL208c NUC1 nuclease, mitochondrial E1 component YDL013w HEX3 hexose metabolism-related protein YMR234w RNH1 ribonuclease H YDR148c KGD2 2-oxoglutarate dehydrogenase complex YDL182w LYS20 homocitrate synthase YPL123c similarity to ribonucleases E2 component YOR126c EST2 isoamyl acetate hydrolytic enzyme YGR195w weak similarity to P. aeruginosa RNase YGR240c PFK1 6-phosphofructokinase, α subunit YNL037c IDH1 isocitrate dehydrogenase (NAD+) subunit PH YMR205c PFK2 6-phosphofructokinase, β subunit 1, mitochondrial YIL107c PFK26 6-phosphofructose-2-kinase, isoenzyme 1 YOR136w IDH2 isocitrate dehydrogenase (NAD+) subunit nucleotide transport YOL136c PFK27 6-phosphofructose-2-kinase, isoenzyme 2 2, mitochondrial YMR056c AAC1 ADP/ATP carrier protein (MCF) YHR183w GND1 6-phosphogluconate dehydrogenase YDL066w IDP1 isocitrate dehydrogenase (NADP+), YBL030c AAC2 ADP/ATP carrier protein (MCF) YBR001c NTH2 α,α-trehalase mitochondrial YBR085w AAC3 ADP/ATP carrier protein (MCF) YDR074w TPS2 α,α-trehalose-phosphate synthase, 105K YLR174w IDP2 isocitrate dehydrogenase, cytosolic YER056c FCY2 purine-cytosine permease subunit YER065c ICL1 isocitrate lyase YER060w FCY21 purine-cytosine permease YMR261c TPS3 α,α-trehalose-phosphate synthase, 115K YOR336w KRE5 killer toxin-resistance protein YOR222w similarity to ADP/ATP carrier proteins subunit YML054c CYB2 lactate dehydrogenase cytochrome b2 YPR011c similarity to ADP/ATP carrier proteins and YML100w TSL1 α,α-trehalose-phosphate synthase, 123K YDL168w SFA1 long-chain alcohol dehydrogenase Graves disease carrier protein subunit YOL126c MDH2 malate dehydrogenase, cytoplasmic YOR071c similarity to allantoin or uracil transport YBR126c TPS1 α,α-trehalose-phosphate synthase, 56K YKL085w MDH1 malate dehydrogenase, mitochondrial proteins subunit YDL078c MDH3 malate dehydrogenase, peroxisomal YOR192c similarity to allantoin or uracil transport YJR131w MNS1 α-1,2-mannosidase YNL117w MLS1 malate synthase 1 proteins YDR483w KRE2 α-1,2-mannosyltransferase YIR031c DAL7 malate synthase 2 YLR237w similarity to allantoin transport protein YER001w MNN1 α-1,3-mannosyltransferase YDL055c PSA1 mannose-1-phosphate guanyltransferase YGR096w similarity to bovine Graves disease carrier YGL038c OCH1 α-1,6-mannosyltransferase YER003c PMI40 mannose-6-phosphate isomerase protein YAL054c ACS1 acetyl-CoA synthetase YGL065c ALG2 mannosyltransferase YHR002w similarity to bovine mitochondrial carrier YLR153c ACS2 acetyl-CoA synthetase YNL219c ALG9 mannosyltransferase protein/Grave’s disease carrier protein YPR026w ATH1 acid trehalase, vacuolar YKR061w KTR2 mannosyltransferase YGL186c similarity to hypothetical protein YER060w YBR299w MAL32 α-glucosidase YDL095w PMT1 mannosyltransferase and weak similarity to Fcy2p YGR292w MAL12 α-glucosidase of the MAL1 locus YAL023c PMT2 mannosyltransferase YBL042c strong similarity to allantoin and uracil YOR377w ATF1 alcohol acetyltransferase YOR321w PMT3 mannosyltransferase transport proteins YOL086c ADH1 alcohol dehydrogenase I YBL082c RHK1 mannosyltransferase YER060w-a FCY22 strong similarity to Fcy2p YMR303c ADH2 alcohol dehydrogenase II YJL139c YUR1 mannosyltransferase YBR021w FUR4 uracil permease YMR083w ADH3 alcohol dehydrogenase III YJL153c INO1 myo-inositol-1-phosphate synthase YGL256w ADH4 alcohol dehydrogenase IV YPL175w SPT14 N-acetylglucosaminyltransferase other nucleotide-metabolism activities YBR145w ADH5 alcohol dehydrogenase V YDR001c NTH1 neutral trehalase (α,α-trehalase) YDR226w ADK1 adenylate kinase, cytosolic YGR177c ATF2 alcohol O-acetyltransferase YPR006c ICL2 non-functional isocitrate lyase YER170w ADK2 adenylate kinase, mitochondrial YCL040w GLK1 aldohexose specific glucokinase YJL002c OST1 oligosaccharyltransferase α subunit YDR454c GUK1 guanylate kinase YGL156w AMS1 α-mannosidase YEL002c WBP1 oligosaccharyltransferase β subunit YKL067w YNK1 nucleoside diphosphate kinase YGL027c CWH41 β-1,6-glucan assembly protein YMR149w SWP1 oligosaccharyltransferase δ subunit YDL125c HNT1 similarity to protein kinase C inhibitor-I YHR101c BIG1 big cells phenotype YOR103c OST2 oligosaccharyltransferase ε subunit YDR305c HNT2 strong similarity to S. pombe diadenosine YBR110w ALG1 β-mannosyltransferase YOR085w OST3 oligosaccharyltransferase γ subunit 5’,5’’’-P1,P4-tetraphosphate asymmetrical YBR084w MIS1 C1-tetrahydrofolate synthase, YDL232w OST4 oligosaccharyltransferase subunit hydrolase mitochondrial YGL022w STT3 oligosaccharyltransferase subunit YNL322c KRE1 cell-wall protein YEL058w PCM1 phosphoacetylglucosamine mutase phosphate metabolism YJL174w KRE9 cell-wall synthesis protein YKR097w PCK1 phosphoenolpyruvate carboxykinase YJL099w CHS6 chitin biosynthesis protein YMR105c PGM2 phosphoglucomutase, major isoform phosphate utilization YNL192w CHS1 chitin synthase I YKL127w PGM1 phosphoglucomutase, minor isoform YHR044c DOG1 2-deoxyglucose-6-phosphate YBR038w CHS2 chitin synthase II YGR256w GND2 phosphogluconate dehydrogenase phosphatase YBR023c CHS3 chitin synthase III YCR012w PGK1 phosphoglycerate kinase YNR001c CIT1 citrate (si)-synthase, mitochondrial YKL152c GPM1 phosphoglycerate mutase

NATURE | VOL 387 | SUPP | 29 MAY 1997 37 gazetteer

YOL056w GPM3 phosphoglycerate mutase YJL218w strong similarity to E. coli galactoside YCR081w SRB8 DNA-directed RNA polymerase II YFL045c SEC53 phosphomannomutase O-acetyltransferase holoenzyme and Kornberg’s mediator YCR034w GNS1 probable 1,3-—glucan synthase subunit YDR248c strong similarity to E. coli thermoresistant (SRB) subcomplex subunit YIL045w PIG2 Protein interacting with Gsy2p gluconokinase YNL025c SSN8 DNA-directed RNA polymerase II YIL085c KTR7 putative α-1,2-mannosyltransferase YIL172c strong similarity to Fsp2p holoenzyme and Kornberg’s mediator YNL029c KTR5 putative mannosyltransferase YDL037c strong similarity to glucan (SRB) subcomplex subunit, cyclin C YGR199w PMT6 putative mannosyltransferase 1,4-—glucosidase homologue YGL062w PYC1 pyruvate carboxylase, isozyme 1 YDR516c strong similarity to glucokinase YLR071c RGR1 DNA-directed RNA polymerase II YBR218c PYC2 pyruvate carboxylase, isozyme 2 YOR299w strong similarity to hypothetical protein holoenzyme subunit YDR081c PDC2 pyruvate decarboxylase regulatory protein YMR237w and similarity to Chs6p YBR253w SRB6 DNA-directed RNA polymerase II YLR044c PDC1 pyruvate decarboxylase, isozyme 1 YMR237w strong similarity to hypothetical protein suppressor protein YLR134w PDC5 pyruvate decarboxylase, isozyme 2 YOR299w and similarity to CHS6 protein YOR047c STD1 dosage-dependent modulator of glucose YGR087c PDC6 pyruvate decarboxylase, isozyme 3 YNL009w strong similarity to isocitrate repression YER178w PDA1 pyruvate dehydrogenase (lipoamide) dehydrogenase YJL155c FBP26 fructose-2,6-bisphosphatase α subunit YJL216c strong similarity to Mal62p YPL037c EGD1 GAL4 DNA-binding enhancer protein YBR221c PDB1 pyruvate dehydrogenase (lipoamide) YGR287c strong similarity to maltase YDR009w GAL3 galactokinase β subunit YOR099w KTR1 strong similarity to mannosyltransferases YLL016w SDC25 GDP/GTP exchange factor YGR193c PDX1 pyruvate dehydrogenase complex protein YDR368w YPR1 strong similarity to members of the YLR310c CDC25 GDP/GTP exchange factor for Ras1p and X aldo/keto reductase family Ras2p YAL038w CDC19 pyruvate kinase YDL021w GPM2 strong similarity to phosphoglycerate YGR070w ROM1 GDP/GTP exchange protein for Rho1p YNL048w ALG11 required for asparagine-linked mutase Gpm1p YLR371w ROM2 GDP/GTP exchange protein for Rho1p glycosylation YMR323w strong similarity to phosphopyruvate YDR176w NGG1 general transcriptional adaptor or co- YCR036w RBK1 ribokinase hydratases activator YJL137c GLG2 self-glucosylating initiator of glycogen YJR153w strong similarity to polygalacturonases YER054c GIP2 Glc7p-interacting protein synthesis YDL080c strong similarity to pyruvate YNL236w SIN4 global regulator protein YMR306w similarity to 1,3-—glucan synthases decarboxylases YHL025w SNF6 global transcription activator YAL060w FUN49 similarity to alcohol/sorbitol YOR347c strong similarity to pyruvate kinase YER027c GAL83 glucose repression protein dehydrogenase YGR244c strong similarity to rumen fungus YNL199c GCR2 glycolytic genes transcriptional activator YAL061w FUN50 similarity to alcohol/sorbitol β-succinyl-CoA synthetase YOR101w RAS1 GTP-binding protein dehydrogenase YKL029c strong similarity to S. pombe malate YNL098c RAS2 GTP-binding protein YMR318c similarity to alcohol-dehydrogenase oxireductase YPR165w RHO1 GTP-binding protein of the RHO subfamily YDL124w similarity to aldose reductases YBL001c strong similarity to S. xylosus glucose of RAS-like proteins YHR204w similarity to α-mannosidases kinase YNL090w RHO2 GTP-binding protein of the RHO subfamily YPL088w similarity to aryl-alcohol dehydrogenases YLR164w strong similarity to Sdh4p of RAS-like proteins YML070w similarity to C. feundii dihydroxyacetone YDL246c strong similarity to Sor1p YDR420w HKR1 Hansenula MrakII k9 killer toxin-resistance kinase YJL045w strong similarity to succinate protein YIL124w similarity to C. perfringens nanH protein dehydrogenase flavoprotein YGL253w HXK2 hexokinase II YDR371w similarity to chitinases YGR043c strong similarity to transaldolase YPL002c SNF8 involved in glucose derepression YIR036c similarity to E. coli 3-ketoacyl-ACP YNR071c strong similarity to UDP-glucose YOR125c CAT5 involved in glucose repression reductase 4-epimerase Gal10p YML048w EFF2 involved in glucose repression YBR149w similarity to Gcy1p and aldose reductases YDR384c strong similarity to Y. lipolytica GPR1 YNL201c involved in regulation of carbon YBR056w similarity to glucan 1,3-—glucosidase gene metabolism YIL169c similarity to glucan 1,4-—glucosidase YHR210c strong similarity UDP-glucose-4-epimerase YGR227w DIE2 ITR1 expression promoting protein YOL155c similarity to glucan 1,4-—glucosidase YKL148c SDH1 succinate dehydrogenase flavoprotein YBR297w MAL33 maltose fermentation regulatory protein Mal5p YDR178w SDH4 succinate dehydrogenase membrane YGR288w MAL13 maltose pathway regulatory protein YNL274c similarity to glycerate- and formate- anchor subunit for Sdh2p YLR131c ACE2 metallothionein expression activator dehydrogenases YIL162w SUC2 sucrose hydrolyzing enzyme YDR422c SIP1 multicopy suppressor of snf1 YPL113c similarity to glycerate dehydrogenases YJR075w HOC1 suppressor of pkc1 YML051w GAL80 negative regulator for expression of YPR184w similarity to glycogen debranching YLR354c TAL1 transaldolase galactose-induced genes enzymes YPR074c TKL1 transketolase 1 YNL076w MKS1 negative regulator of RAS-cAMP pathway YDL131w similarity to homocitrate synthases and YBR117c TKL2 transketolase 2 YIL119c RPI1 negative regulator of RAS-cAMP pathway isopropylmalate synthases YDR050c TPI1 triose-phosphate isomerase YLR025w SNF7 nuclear protein YJR096w similarity to Leishmania reductase YBR019c GAL10 UDP-glucose 4-epimerase YGL115w SNF4 nuclear regulatory protein YKR096w similarity to mitochondrial aldehyde YBR018c GAL7 UDP-glucose-hexose-1-phosphate YLR273c PIG1 protein interacting with Gsy2p dehydrogenase Ald1p uridylyltransferase YIL045w PIG2 protein Interacting with Gsy2p YGL257c similarity to Mnn1p YFR015c GSY1 UDP-glucose-starch glucosyltransferase, YDL006w PTC1 protein ser/thr phosphatase 2c YIL014w similarity to Mnn1p isoform 1 YDL134c PPH21 protein ser/thr phosphatase PP2A-1 YEL020c similarity to O. formigenes oxalyl-CoA YLR258w GSY2 UDP-glucose-starch glucosyltransferase, YDL188c PPH22 protein ser/thr phosphatase PP2A-2 decarboxylase isoform 2 YBL061c SKT5 protoplast regeneration and killer toxin YDL093w PMT5 similarity to O-mannosyltransferases YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate resistance protein Pmt1p-Pmt4p transferase YOL110w SHR5 RAS suppressor YMR278w similarity to phosphomannomutases YKL035w UGP1 UTP-glucose-1-phosphate YJR095w ACR1 regulator of acetyl-CoA synthetase activity YDR307w similarity to Pmt1p uridylyltransferase YKL038w RGT1 regulator of glucose induced genes YDR380w similarity to pyruvate decarboxylases YKR043c weak similarity to phosphoglycerate YDR028c REG1 regulatory subunit for protein YDR245w MNN10 similarity to S. pombe mutase phosphatase Glc7p galactosyltransferase YOR283w weak similarity to phosphoglycerate YMR311c GLC8 regulatory subunit for protein ser/thr YLR070c similarity to sugar dehydrogenases mutases phosphatase Glc7p YNR059w similarity to to α-1,3-mannosyltransferase YBR050c REG2 regulatory subunit of type I protein YHL012w similarity to UDP glucose regulation of carbohydrate utilization phosphatase pyrophosphorylase YGR240c PFK1 6-phosphofructokinase, α subunit YDR277c MTH1 repressor of hexose transport genes YJR159w SOR1 sorbitol dehydrogenase YMR205c PFK2 6-phosphofructokinase, β subunit YNR052c POP2 required for glucose derepression YIL099w SGA1 sporulation specific glucan YIL107c PFK26 6-phosphofructose-2-kinase, isoenzyme 1 YJR090c GRR1 required for glucose repression and for 1,4-—glucosidase YOL136c PFK27 6-phosphofructose-2-kinase, isoenzyme 2 glucose and cation transport YER096w SHC1 sporulation-specific protein YBR126c TPS1 α,α-trehalose-phosphate synthase, 56K YGL252c RTG2 retrograde regulation protein YLR307w CDA1 sporulation-specific chitin deacetylase subunit YJR076c CDC11 septin YLR308w CDA2 sporulation-specific chitin deacetylase YHR047c AAP1 alanine/arginine aminopeptidase YHR107c CDC12 septin YNL331c strong similarity to aryl-alcohol reductase YGR229c KNR4 β-1,3-glucan synthesis protein YER133w GLC7 ser/thr phosphoprotein phosphatase 1, YCR107w strong similarity to aryl-alcohol reductases YOL067c RTG1 basic helix-loop-helix transcription factor catalytic subunit YPL017c strong similarity to dihydrolipoamide YOR344c TYE7 basic helix-loop-helix transcription factor YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, dehydrogenases YGR166w KRE11 β-glucan synthesis-associated protein regulatory subunit YBR205w KTR3 strong similarity to YBL103c RTG3 bHLH/zip transcription factor YLR113w HOG1 ser/thr protein kinase of MAP kinase α-1,2-mannosyltransferase YPL161c BEM4 bud emergence protein (MAPK) family YBR199w KTR4 strong similarity to YGL209w MIG2 C2H2 zinc-finger protein YLR345w similarity to 6-phosphofructo-2-kinase α-1,2-mannosyltransferase YIL033c SRA1 cAMP dependent protein kinase, YCR028c FEN2 similarity to allantoate permease YPL053c KTR6 strong similarity to regulatory subunit transporter α-1,2-mannosyltransferase Kre2p YDR477w SNF1 carbon catabolite derepressing ser/thr YFL053w similarity to C. freundii dihydroxyacetone YJL221c FSP2 strong similarity to α-D-glucosidase protein kinase kinase YOL157c strong similarity to α-glucosidases YCR002c CDC10 cell division control protein YDL225w similarity to Cdc11p, Cdc3p and human YCR105w strong similarity to alcohol YLR330w CHS5 chitin synthesis protein CDC10 protein dehydrogenases YDR073w SNF11 component of SWI/SNF transcription YHR193c EGD2 similarity to human α-NAC YDL243c strong similarity to aryl-alcohol activator complex YDL203c similarity to Skt5p dehydrogenase YOR290c SNF2 component of SWI/SNF transcription YNL257c SIP3 Snf1p protein kinase interacting protein YJR155w strong similarity to aryl-alcohol activator complex YLR150w MPT4 specific affinity for guanine-rich dehydrogenase YBR289w SNF5 component of SWI/SNF transcription quadruplex nucleic acids YFL056c strong similarity to aryl-alcohol activator complex YFL052w strong similarity to Mal63p, Mal23p and dehydrogenases YPL016w SWI1 component of SWI/SNF transcription Mal33p YFL057c strong similarity to aryl-alcohol activator complex YHR155w strong similarity to Snf1p-interacting dehydrogenases YPL042c SSN3 cyclin-dependent ser/thr protein kinase protein Sip3p YOL165c strong similarity to aryl-alcohol YNL216w RAP1 DNA-binding protein with repressor and YNR002c FUN34 strong similarity to Y. lipolytica glyoxylate dehydrogenases activator activity pathway regulator GPR1 YKR027w strong similarity to Chs6p YOL051w GAL11 DNA-directed RNA polymerase II YCR010c strong similarity to Y. lipolytica GPR1 YHR104w strong similarity to D-xylose holoenzyme and Kornberg’s mediator protein and Fun34p 1-dehydrogenase (SRB) subcomplex subunit YIL154c (IMP2) sugar utilization regulatory protein YEL070w strong similarity to E. coli D-mannonate YDR443c SCA1 DNA-directed RNA polymerase II YPL026c SKS1 suppressor kinase of snf3 oxidoreductase holoenzyme and Kornberg’s mediator YPL129w ANC1 TFIIF subunit (transcription initiation YNR073c strong similarity to E. coli D-mannonate (SRB) subcomplex subunit factor), 30K oxidoreductase, identical to YEL070w YPL248c GAL4 transcription factor YMR125w GCR3 transcription factor for glycolytic genes

38 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YMR280c CAT8 transcription factor involved in YPL069c BTS1 geranylgeranyl diphosphate synthase YGL162w SUT1 hypoxic protein involved in sterol uptake gluconeogenesis YGL126w SCS3 inositol phospholipid synthesis protein YMR208w ERG12 mevalonate kinase YMR043w MCM1 transcription factor of the MADS box YOR237w HES1 involved in ergosterol biosynthesis YHL020c OPI1 negative regulator of phospholipid family YPL145c KES1 involved in ergosterol biosynthesis biosynthesis pathway YJL176c SWI3 transcription regulatory protein YPL117c IDI1 isopentenyl-diphosphate δ-isomerase YDR207c UME6 negative transcriptional regulator YPL075w GCR1 transcriptional activator YHR072w ERG7 lanosterol synthase YAL051w OAF1 peroxisome proliferating transcription YOL116w MSN1 transcriptional activator YMR246w FAA4 long-chain-fatty-acid-CoA ligase factor YKL062w MSN4 transcriptional activator YNL219c ALG9 mannosyltransferase YOR363c PIP2 peroxisome proliferating transcription YGL035c MIG1 transcriptional repressor YJR073c OPI3 methylene-fatty-acyl-phospholipid factor YIL147c SLN1 two-component signal transducer synthase YNL169c PSD1 phosphatidylserine decarboxylase 1 YLR006c SSK1 two-component signal transducer YNR043w MVD1 mevalonate pyrophosphate YAL013w DEP1 regulator of phospholipid metabolism YJL128c PBS2 tyrosine protein kinase of the MAP kinase decarboxylase YMR207c HFA1 similarity to acetyl-CoA carboxylase kinase family YPL076w GPI2 N-acetylglucosaminyl-phosphatidylinositol YCR028c FEN2 similarity to allantoate permease YLR258w GSY2 UDP-glucose-starch glucosyltransferase, biosynthetic protein transporter isoform 2 YPL175w SPT14 N-acetylglucosaminyltransferase YMR043w MCM1 transcription factor of the MADS box YDR216w ADR1 zinc-finger transcription factor YGR157w CHO2 phosphatidylethanolamine family N-methyltransferase YOL004w SIN3 transcription regulatory protein carbohydrate transport YDL142c PGS1 phosphatidylglycerophosphate synthase YCL040w GLK1 aldohexose specific glucokinase YNL169c PSD1 phosphatidylserine decarboxylase 1 lipid and fatty-acid transport YKL217w JEN1 carboxylic acid transporter protein YGR170w PSD2 phosphatidylserine decarboxylase 2 YGR037c ACB1 acyl-CoA-binding protein (diazepam- YBR291c CTP1 citrate transport protein, mitochondrial YCL004w PEL1 phosphatidylserine synthase binding inhibitor) (MCF) YMR220w ERG8 phosphomevalonate kinase YNL130c CPT1 diacylglycerol cholinephosphotransferase YLR348c dicarboxylate carrier protein YCR034w GNS1 probable 1,3-—glucan synthase subunit YBR041w FAT1 fatty-acid transporter YLR081w GAL2 galactose (and glucose) permease YGL001c putative 3-—hydroxysteroid dehydrogenase YKL188c PAT1 long-chain-fatty-acid transporter YGR289c AGT1 general α-glucoside permease YJL196c ELO1 required for elongation of fatty acids YPL147w PXA1 long-chain-fatty-acid transporter YLL043w FPS1 glycerol channel protein YGR216c GPI1 required for N-acetylglucosaminyl YOR317w FAA1 long-chain-fatty-acid-CoA ligase YNL318c HXT14 hexose transport protein phosphatidylinositol synthesis YER015w FAA2 long-chain-fatty-acid-CoA ligase YJL214w HXT8 hexose transport protein YML008c ERG6 S-adenosyl-methionine δ-24-sterol-c- YMR246w FAA4 long-chain-fatty-acid-CoA ligase YJL219w HXT9 hexose transport protein methyltransferase YAR035w YAT1 outer carnitine acetyltransferase, YFL011w HXT10 hexose transporter YMR296c LCB1 serine C-palmitoyltransferase subunit mitochondrial YDL194w SNF3 high-affinity glucose transporter YDR062w LCB2 serine C-palmitoyltransferase subunit YCL043c PDI1 protein disulphide-isomerase YEL069c HXT13 high-affinity hexose transporter YLR058c SHM2 serine hydroxymethyltransferase, YER024w similarity to carnitine O-acetyltransferase YMR011w HXT2 high-affinity hexose transporter cytoplasmic Yat1p YDR343c HXT6 high-affinity hexose transporter YBR263w SHM1 serine hydroxymethyltransferase, YKL174c similarity to choline transport protein YDR342c HXT7 high-affinity hexose transporter mitochondrial Ctr1p YOL156w HXT11 low-affinity glucose transporter YMR207c HFA1 similarity to acetyl-CoA carboxylase YNR056c similarity to choline transport protein YHR094c HXT1 low-affinity hexose transporter YDR147w similarity to choline kinase Ctr1p YDR345c HXT3 low-affinity hexose transporter YBR159w similarity to human 17-—hydroxysteroid YHR123w EPT1 sn-1,2-diacylglycerol ethanolamine- and YDR497c ITR1 major myo-inositol permease dehydrogenase cholinephosphotransferase YBR298c MAL31 maltose permease YDR376w ARH1 similarity to human adrenodoxin YHR092c HXT4 moderate- to low-affinity glucose reductase lipid and fatty-acid binding transporter YML131w similarity to human leukotriene b4 YHR001w similarity to Kes1p YOL103w ITR2 myo-inositol transport protein 12-hydroxydehydrogenase YMR020w FMS1 suppressor of fenpropimorph resistance YIR035c similarity to C. lanceolata 3-oxoacyl-[acyl- YAR042w OSH1 similarity to human oxysterol binding mutation fen2 carrier-protein] reductase protein YBR241c similarity to glucose transport proteins YDR208w MSS4 similarity to human PI P 5-kinase other lipid, fatty-acid and sterol metabolism activities YGL104c similarity to glucose transport proteins YHR001w similarity to Kes1p YBR036c CSG2 calcium dependent regulatory protein YPR021c similarity to human citrate transporter YKR003w similarity to Kes1p, Hes1p and Osh1p YMR079w SEC14 phosphatidylinositol/phosphatidylcholine protein YDL019c similarity to Osh1p transfer protein YDR387c similarity to Itr1p and Itr2p YHR073w similarity to Osh1p, Hes1p, Kes1p YNL264c similarity to Sec14p YDL199c similarity to sugar transporter proteins YGR175c ERG1 squalene monooxygenase YKL091c strong similarity to Sec14p YFL040w similarity to yeast glucose transport YGL055w OLE1 stearoyl-CoA desaturase YIL002c SJH1 synaptojanin homologue 1 proteins YGL012w ERG4 sterol C-24 reductase YDR302w weak similarity to human GPI-anchor YHR096c HXT5 strong similarity to hexose transporters YLR372w SUR4 sterol isomerase biosynthesis protein YDL245c HXT15 strong similarity to Hxt17p and Haxt7p YKL192c strong similarity to acyl-carrier proteins YJR160c strong similarity to Mal3Tp YNL045w strong similarity to human leukotriene-A4 biosynthesis of vitamins, cofactors and YDR536w STL1 strong similarity to members of the sugar hydrolase prosthetic groups permease family YDL247w strong similarity to sugar transport breakdown of lipids and phospholipids metabolism of vitamins, cofactors and prosthetic groups proteins YPL268w PLC1 1-phosphatidylinositol-4,5-bisphosphate YOL096c COQ3 3,4-dihydroxy-5-hexaprenylbenzoate YIL170w HXT12 strong similarity to sugar transport phosphodiesterase methyltransferase proteins YGL205w POX1 acyl-CoA oxidase YDR232w HEM1 5-aminolevulinate synthase YIL171w HXT12 strong similarity to sugar transport YMR008c PLB1 phospholipase B (lysophospholipase) YOL143c RIB4 6,7-dimethyl-8-ribityllumazine synthase proteins YKR031c SPO14 phospholipase D YGR286c BIO2 biotin synthetase YJR158w HXT16 strong similarity to sugar transport YLR020c similarity to triacylglycerol lipase YGR204w ADE3 C1-tetrahydrofolate synthase, cytoplasmic proteins YLL012w similarity to triacylglycerol lipases YBR084w MIS1 C1-tetrahydrofolate synthase, YNR072w HXT17 sugar transport protein YJL068c strong similarity to human esterase D mitochondrial YDL138w RGT2 suppressor of snf3 mutant YOL011w strong similarity to phospholipases YDR044w HEM13 coproporphyrinogen III oxidase YMR006c strong similarity to Plb1p YPL132w COX11 cytochrome c oxidase assembly protein lipid, fatty-acid and sterol metabolism YKL140w TGL1 triacylglycerol lipase YNR058w BIO3 DAPA aminotransferase YDR058c TGL2 triacylglycerol lipase YDR487c RIB3 DBP synthase lipid, fatty-acid and sterol biosynthesis YJR107w weak similarity to acylglycerol lipase YOL066c RIB2 DRAP deaminase YML075c HMG1 3-hydroxy-3-methylglutaryl-CoA YBR204c weak similarity to peroxisomal serine- YPL172c COX10 farnesyl transferase reductase 1 active lipase YOR176w HEM15 ferrochelatase YLR450w HMG2 3-hydroxy-3-methylglutaryl-CoA YDL045c FAD1 flavin adenine dinucleotide (FAD) reductase 2 lipid, fatty-acid and sterol utilization synthetase YML126c HMGS 3-hydroxy-3-methylglutaryl-CoA synthase YIL160c POT1 acetyl-CoA C-acyltransferase, peroxisomal YGR267c FOL2 GTP cyclohydrolase I YPL028w ERG10 acetyl-CoA C-acetyltransferase, cytosolic YIL009w FAA3 acyl-CoA synthase YBL033c RIB1 GTP cyclohydrolase II YNR016c ACC1 acetyl-CoA carboxylase YMR013c SEC59 dolichol kinase YBR003w COQ1 hexaprenyl pyrophosphate synthetase YCR048w ARE1 acyl-CoA sterol acyltransferase YDR331w GPI8 essential for GPI-anchor attachment YBR153w RIB7 HTP reductase YNR019w ARE2 acyl-CoA sterol acyltransferase YDR410c STE14 farnesyl cysteine carboxyl- YOR196c LIP5 lipoic acid synthase YIL009w FAA3 acyl-CoA synthase methyltransferase YHR042w NCP1 NADPH-cytochrome P450 reductase YGR037c ACB1 acyl-CoA-binding protein (diazepam- YPL172c COX10 farnesyl transferase YOR209c NPT1 nicotinate phosphoribosyltransferase binding inhibitor) YOR370c MSI4 geranylgeranyltransferase regulatory YNR033w ABZ1 para-aminobenzoate synthase YBR222c PCS60 AMP-binding protein, peroxisomal subunit YNR041c COQ2 para-hydroxybenzoate- YER061c CEM1 β-keto-acyl-ACP synthase YGL155w CDC43 geranylgeranyltransferase type I β subunit polyprenyltransferase YNL280c ERG24 C-14 sterol reductase YPR176c BET2 geranylgeranyltransferase type II β subunit YOR184w SER1 phosphoserine transaminase YMR015c ERG5 C-22 sterol desaturase YJL031c BET4 geranylgeranyltransferase, α subunit YDL205c HEM3 porphobilinogen deaminase YGR060w ERG25 C-4 sterol methyl oxidase YFL014w HSP12 heat-shock protein YGL040c HEM2 porphobilinogen synthase YLR056w ERG3 C-5 sterol desaturase YBR003w COQ1 hexaprenyl pyrophosphate synthetase YER014w HEM14 protoporphyrinogen oxidase, YMR202w ERG2 C-8 sterol isomerase YKR009c FOX2 hydratase-dehydrogenase-epimerase, mitochondrial YML042w CAT2 carnitine O-acetyltransferase peroxisomal YNR057c BIO4 putative dethiobiotin synthetase YPR113w PIS1 CDP diacylglycerol-inositol YOR317w FAA1 long-chain-fatty-acid-CoA ligase YBR035c PDX3 pyridoxamine-phosphate oxidase 3-phosphatidyltransferase YER015w FAA2 long-chain-fatty-acid-CoA ligase YBR256c RIB5 riboflavin synthase, α subunit YER026c CHO1 CDP-diacylglycerol serine YMR246w FAA4 long-chain-fatty-acid-CoA ligase YER043c SAH1 S-adenosyl-L-homocysteine hydrolase O-phosphatidyltransferase YDL078c MDH3 malate dehydrogenase, peroxisomal YNL256w similarity to bacterial dihydropteroate YBR029c CDS1 CDP-diacylglycerol synthase YLR195c NMT1 N-myristoyltransferase synthase YLR133w CKI1 choline kinase YJR066w TOR1 phosphatidylinositol 3-kinase YKL027w similarity to E. coli molybdopterin- YGR007w MUQ1 choline phosphate cytidylyltransferase YKL019w RAM2 protein farnesyltransferase, α subunit converting factor chlN YGR202c PCT1 cholinephosphate cytidylyltransferase YDL090c RAM1 protein farnesyltransferase, β subunit YIL145c similarity to E. coli pantothenate YNL111c CYB5 cytochrome b5 YHR013c ARD1 protein N-acetyltransferase subunit synthetase YHR007c ERG11 cytochrome P450 lanosterol YDL040c NAT1 protein N-acetyltransferase subunit YGR255c similarity to E. coli ubiH protein 14a-demethylase YMR113w similarity to folylpolyglutamate YHR190w ERG9 farnesyl-diphosphate farnesyltransferase regulation of lipid, fatty-acid and sterol biosynthesis synthetases and strong similarity to YJL167w ERG20 farnesyl-pyrophosphate synthetase YBL015w ACH1 acetyl-CoA hydrolase hypothetical protein YKL132c YDL052c SLC1 fatty acyltransferase YDR123c INO2 basic helix-loop-helix (BHLH) transcription YGL125w similarity to human YPL231w FAS2 fatty-acyl-CoA synthase, α subunit factor methylenetetrahydrofolate reductase YKL182w FAS1 fatty-acyl-CoA synthase, β subunit YOL108c INO4 basic helix-loop-helix transcription factor

NATURE | VOL 387 | SUPP | 29 MAY 1997 39 gazetteer

YPL023c similarity to human YOR031w CRS5 suppressor of cup1 deletion, YGR192c TDH3 glyceraldehyde-3-phosphate methylenetetrahydrofolate reductase metallothionein-like protein dehydrogenase 3 YFR047c similarity to human quinolinate YCL037c SRO9 suppressor of rho3 YOL059w GPD3 glycerol-3-phosphate dehydrogenase phosphoribosyltransferase YMR243c ZRC1 zinc- and cadmium-resistance protein (NAD+), mitochondrial YHR111w similarity to molybdopterin biosynthesis YFR053c HXK1 hexokinase I proteins homeostasis of other ions YGL253w HXK2 hexokinase II YOL151w similarity to plant dihydroflavonol-4- YDL128w VCX1 Ca2+-transport (H+/Ca2+ exchange) protein, YCR012w PGK1 phosphoglycerate kinase reductases vacuolar YKL152c GPM1 phosphoglycerate mutase YMR222c similarity to S. pombe dihydrofolate YGL006w PMC1 Ca2+-transporting P-type ATPase YOL056w GPM3 phosphoglycerate mutase reductase YGL167c PMR1 Ca2+-transporting P-type ATPase YER178w PDA1 pyruvate dehydrogenase (lipoamide) YOR241w similarity to tetrahydrofolylpolyglutamate YGR217w CCH1 calcium channel protein α subunit synthase YLR348c dicarboxylate carrier protein YBR221c PDB1 pyruvate dehydrogenase (lipoamide) YJR142w similarity to thiamin pyrophosphokinase YKL016c ATP7 F1F0-ATPase complex, F0 D subunit β subunit YKR069w similarity to uroporphyrinogen YBL099w ATP1 F1F0-ATPase complex, F1 α subunit YGR193c PDX1 pyruvate dehydrogenase complex protein methyltransferases YJR121w ATP2 F1F0-ATPase complex, F1 β subunit X YGL039w similarity to V. vinifera dihydroflavonol YDL004w ATP16 F1F0-ATPase complex, F1 δ subunit YAL038w CDC19 pyruvate kinase reductase YPL078c ATP4 F1F0-ATPase complex, F1 δ subunit YLR345w similarity to 6-phosphofructo-2-kinase YBR176w strong similarity to E. coli 3-methyl-2- YPL271w ATP15 F1F0-ATPase complex, F1 ε subunit YDL021w GPM2 strong similarity to phosphoglycerate oxobutanoate hydroxymethyltransferase YBR039w ATP3 F1F0-ATPase complex, F1 γ subunit mutase Gpm1p YHR003c strong similarity to molybdopterin- YDR298c ATP5 F1F0-ATPase complex, OSCP subunit YMR323w strong similarity to phosphopyruvate converting factor homologue YKL027w YLR295c ATP14 F1F0-ATPase complex, subunit h hydratases YDL036c strong similarity to Rib2p YCR024c-a PMP1 H+-ATPase subunit, plasma membrane YOR347c strong similarity to pyruvate kinase YOL049w strong similarity to S. pombe Gsa1p YEL017c-a PMP2 H+-ATPase subunit, plasma membrane YKL029c strong similarity to S. pombe malate YOR143c THI80 thiamin pyrophosphokinase YMR054w STV1 H+-ATPase V0 domain 102K subunit, oxireductase YPL214c THI6 thiamin-phosphate pyrophosphorylase vacuolar YMR125w GCR3 transcription factor for glycolytic genes and hydroxyethylthiazole kinase YHR039c-a VMA10 H+-ATPase V0 domain 13K subunit, YDR050c TPI1 triose-phosphate isomerase YDR047w HEM12 uroporphyrinogen decarboxylase vacuolar YKR043c weak similarity to phosphoglycerate YOR278w HEM4 uroporphyrinogen III synthase YEL027w CUP5 H+-ATPase V0 domain 17K subunit, mutase vacuolar YOR283w weak similarity to phosphoglycerate utilization of vitamins, cofactors and prosthetic groups YPL234c TFP3 H+-ATPase V0 domain 17K subunit, mutases YDL141w BPL1 biotin holocarboxylase synthetase vacuolar YBR092c PHO3 constitutive acid phosphatase YLR447c VMA6 H+-ATPase V0 domain 36K subunit, gluconeogenesis YAL039c CYC3 holocytochrome c synthase (cytochrome vacuolar c haem lyase) YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YOR393w ERR1 enolase-related protein YKL087c CYT2 holocytochrome c1 synthase vacuolar YPL281c ERR2 enolase-related protein YML120c NDI1 NADH-ubiquinone-6 oxidoreductase YGR020c VMA7 H+-ATPase V1 domain 14K subunit, YLR377c FBP1 fructose-1,6-bisphosphatase YBR093c PHO5 repressible acid phosphatase vacuolar YBR196c PGI1 glucose-6-phosphate isomerase YKL132c similarity to B. subtilis folC protein and YOR332w VMA4 H+-ATPase V1 domain 27K subunit, YER065c ICL1 isocitrate lyase strong similarity to hypothetical protein vacuolar YKR097w PCK1 phosphoenolpyruvate carboxykinase YMR113w YEL051w VMA8 H+-ATPase V1 domain 32K subunit, YCR012w PGK1 phosphoglycerate kinase vacuolar YGL062w PYC1 pyruvate carboxylase 1 regulation of vitamins, cofactors and prosthetic groups YKL080w VMA5 H+-ATPase V1 domain 42K subunit, YBR218c PYC2 pyruvate carboxylase 2 YPR065w ROX1 haem-dependent transcriptional repressor vacuolar YIL167w SDL1 serine dehydratase of hypoxic genes YPR036w VMA13 H+-ATPase V1 domain 54K subunit, YOR347c strong similarity to pyruvate kinase YOR125c CAT5 involved in glucose repression vacuolar YMR280c CAT8 transcription factor involved in YBR127c VMA2 H+-ATPase V1 domain 60K subunit, gluconeogenesis transport of vitamins, cofactors and prosthetic groups vacuolar YDR050c TPI1 triose-phosphate isomerase YIL134w FLX1 FAD carrier protein, mitochondrial (MCF) YDL185w TFP1 H+-ATPase V1 domain 69K subunit, YIL006w similarity to Flx1p vacuolar pentose-phosphate pathway YGL008c PMA1 H+-transporting P-type ATPase other vitamin, cofactor and prosthetic-group activities YPL036w PMA2 H+-transporting P-type ATPase 2 YHR183w GND1 6-phosphogluconate dehydrogenase YDR541c similarity to dihydroflavonol-4-reductases YML123c PHO84 high affinity inorganic phosphate/H+ YOR095c RKI1 D-ribose-5-phosphate ketol-isomerase YGL157w similarity to E. gunnii cinnamyl alcohol symporter YJL121c POS18 D-ribulose-5-phosphate 3-epimerase dehydrogenase YJL129c TRK1 high-affinity potassium transport protein YNL241c ZWF1 glucose-6-phosphate dehydrogenase YER183c similarity to formyltetrahydrofolate cyclo- YBR294w SUL1 high-affinity sulphate transport protein YGR256w GND2 phosphogluconate dehydrogenase ligase YJL117w PHO86 inorganic phospate transporter YGR043c strong similarity to transaldolase YHL018w similarity to human pterin-4-— YLR220w CCC1 involved in calcium regulation YLR354c TAL1 transaldolase carbinolamine dehydratase YCR037c PHO87 member of the phosphate permease YPR074c TKL1 transketolase 1 YGR169c similarity to Rib2p family YBR117c TKL2 transketolase 2 YGR144w THI4 thiamine-repressed protein YJL093c TOK1 outward-rectifier potassium channel YJR077c MIR1 phosphate transport protein, tricarboxylic-acid pathway ionic homeostasis mitochondrial (MCF) YEL031w SPF1 P-type ATPase YIL125w KGD1 2-oxoglutarate dehydrogenase complex homeostasis of metal ions YDR040c ENA1 P-type ATPase involved in Na+ and Li+ E1 component YNL259c ATX1 antioxidant protein and metal efflux YDR148c KGD2 2-oxoglutarate dehydrogenase complex homeostasis factor YDR039c ENA2 P-type ATPase involved in Na+ efflux E2 component YJR049c UTR1 associated with ferric reductase activity YDR038c ENA5 P-type ATPase involved in Na+ efflux YLR304c ACO1 aconitate hydratase YMR058w FET3 cell-surface ferroxidase YLR138w NHA1 putative Na+/H+ antiporter YNR001c CIT1 citrate (si)-synthase, mitochondrial YOR316c COT1 cobalt accumulation protein YBR235w similarity to bumetanide-sensitive Na+-K+- YPR001w CIT3 citrate (si)-synthase, mitochondrial YPL177c CUP9 copper homeostasis protein Cl- cotransport protein YFL018c LPD1 dihydrolipoamide dehydrogenase YDR515w SLF1 copper homeostasis protein YJL094c similarity to E. hirae Na+/H+-antiporter YPL262w FUM1 fumarate hydratase YPR124w CTR1 copper transport protein NapA YNL009w homology to isocitrate dehydrogenase YHR175w CTR2 copper transport protein YNR013c similarity to membrane protein Pho87p YNL037c IDH1 isocitrate dehydrogenase (NAD+) YLR411w CTR3 copper transport protein and hypothetical protein YJL198w subunit 1, mitochondrial YGL166w CUP2 copper-dependent transcription factor YDR456w similarity to NA+/H+ antiporters YOR136w IDH2 isocitrate dehydrogenase (NAD+) YLR214w FRE1 ferric (and cupric) reductase YPR003c similarity to sulphate transporter proteins subunit 2, mitochondrial YKL220c FRE2 ferric (and cupric) reductase YER053c strong similarity to mitochondrial YLR174w IDP2 isocitrate dehydrogenase, cytosolic YOR176w HEM15 ferrochelatase phosphate carrier protein YOL126c MDH2 malate dehydrogenase, cytoplasmic YGL255w ZRT1 high-affinity zinc-transport protein YJL198w strong similarity to Pho87p YOR297c similarity to SDH4 protein YLL009c COX17 interacts genetically with SCO1 and SCO2 YBR296c strong similarity to phosphate-repressible YJL200c strong similarity to aconitate hydratase in cytochrome oxidase assembly phosphate permease YGR244c strong similarity to rumen fungus YBR037c SCO1 involved in stabilization of Cox1p and YLR092w SEL2 strong similarity to Sul1p β-succinyl-CoA synthetase Cox2p YHL016c DUR3 urea transport protein YLR164w strong similarity to Sdh4p YGL071w RCS1 iron-regulated transcriptional repressor YJR040w GEF1 voltage-gated chloride channel protein YMR118c strong similarity to succinate YLR130c ZRT2 low-affininty zinc transporter dehydrogenase YMR319c FET4 low-affinity Fe(II) iron transport protein YJL045w strong similarity to succinate YOL122c SMF1 manganese transporter dehydrogenase flavoprotein YBR290w BSD2 metal homeostasis protein Energy YOR142w strong similarity to succinate-CoA ligase YKL064w MNR2 overexpression overcomes manganese α subunit toxicity glycolysis YKL148c SDH1 succinate dehydrogenase flavoprotein YDR270w CCC2 probable copper-transporting ATPase YLL041c SDH2 succinate dehydrogenase iron-sulphur YBR295w PCA1 P-type Cu2+-transporting ATPase YGR240c PFK1 6-phosphofructokinase, α subunit protein subunit YGL096w similarity to copper homeostasis protein YMR205c PFK2 6-phosphofructokinase, β subunit YDR178w SDH4 succinate dehydrogenase membrane Cup9p YIL107c PFK26 6-phosphofructose-2-kinase, isoenzyme 1 anchor subunit for Sdh2p YDR506c similarity to Fet3p YOL136c PFK27 6-phosphofructose-2-kinase, isoenzyme 2 YOL152w similarity to Fre1p and Fre2p YNL071w LAT1 dihydrolipoamide S-acetyltransferase respiration YGL160w similarity to hypothetical protein YLR047c YGR254w ENO1 enolase I (2-phosphoglycerate and Fre2p dehydratase) YMR282c AEP2 2’-O-ribosyl phosphate transferase YJR126c similarity to transferrin receptor protein YHR174w ENO2 enolase II (2-phosphoglycerate YGR008c STF2 ATPase stabilizing factor YFL041w strong similarity to cell-surface ferroxidase dehydratase) YDL130w-a STF1 ATPase stabilizing factor, 10K Fet3p YOR393w ERR1 enolase-related protein YDR377w ATP17 ATPase synthase subunit f YLL051c strong similarity to ferric reductase Fre2p YPL281c ERR2 enolase-related protein YER061c CEM1 β-keto-acyl-ACP synthase YOR381w strong similarity to ferric reductase Fre2p YKL060c FBA1 fructose-bisphosphate aldolase YIL043c CBR1 cytochrome b5 reductase YOR384w strong similarity to ferric reductase Fre2p YBR196c PGI1 glucose-6-phosphate isomerase YKL150w MCR1 cytochrome b5 reductase YNR060w strong similarity to Fre2p and hypothetical YJL052w TDH1 glyceraldehyde-3-phosphate YKL141w SDH3 cytochrome b560 subunit of respiratory protein YOR381w, and similarity to Fre1p dehydrogenase 1 complex II YBR024w SCO2 strong similarity to Sco1p YJR009c TDH2 glyceraldehyde-3-phosphate YJR048w CYC1 cytochrome c isoform 1 dehydrogenase 2 YEL039c CYC7 cytochrome c isoform 2

40 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YML129c COX14 cytochrome c oxidase assembly protein YLR134w PDC5 pyruvate decarboxylase, isozyme 2 YHR179w OYE2 NAPDH dehydrogenase (old yellow YDR079w PET100 cytochrome c oxidase assembly protein YGR087c PDC6 pyruvate decarboxylase, isozyme3 enzyme), isoform 1 YGL187c COX4 cytochrome c oxidase subunit IV YAL060w FUN49 similarity to alcohol/sorbitol YPL171c OYE3 NAPDH dehydrogenase (old yellow YNL052w COX5A cytochrome c oxidase subunit V.A dehydrogenase enzyme), isoform 3 YIL111w COX5B cytochrome c oxidase subunit Vb YAL061w FUN50 similarity to alcohol/sorbitol YPR006c ICL2 non-functional isocitrate lyase YHR051w COX6 cytochrome c oxidase subunit VI dehydrogenase YOL079w similarity to NADH dehydrogenase YGL191w COX13 cytochrome c oxidase subunit VIa YMR318c similarity to alcohol-dehydrogenase YEL020c similarity to O. formigenes oxalyl-CoA YLR038c COX12 cytochrome c oxidase subunit VIB YHR039c similarity to aldehyde dehydrogenases decarboxylase YMR256c COX7 cytochrome c oxidase subunit VII YPL088w similarity to aryl-alcohol dehydrogenases YDR384c strong similarity to Y. lipolytica GPR1 YDL067c COX9 cytochrome c oxidase subunit VIIA YMR285c similarity to Ccr4p gene YLR395c COX8 cytochrome c oxidase subunit VIII YHL008c similarity to M. formicicum formate YOR065w CYT1 cytochrome c1 dehydrogenase YER154w OXA1 cytochrome oxidase biogenesis protein YKR096w similarity to mitochondrial aldehyde YGR207c ETF-β electron-transferring flavoprotein, dehydrogenase Ald1p Cell growth, cell division and β subunit YDR380w similarity to pyruvate decarboxylases YKL016c ATP7 F1F0-ATPase complex, F0 D subunit YNL331c strong similarity aryl-alcohol reductase DNA synthesis YBL099w ATP1 F1F0-ATPase complex, F1 α subunit YCR107w strong similarity aryl-alcohol reductases YJR121w ATP2 F1F0-ATPase complex, F1 β subunit YCR105w strong similarity to alcohol cell growth YDL004w ATP16 F1F0-ATPase complex, F1 δ subunit dehydrogenases YPL078c ATP4 F1F0-ATPase complex, F1 δ subunit YMR169c ALD4 strong similarity to aldehyde YPL268w PLC1 1-phosphatidylinositol-4,5-bisphosphate YPL271w ATP15 F1F0-ATPase complex, F1 ε subunit dehydrogenase phosphodiesterase YBR039w ATP3 F1F0-ATPase complex, F1 γ subunit YDL243c strong similarity to aryl-alcohol YCR088w ABP1 actin-binding protein YDR298c ATP5 F1F0-ATPase complex, OSCP subunit dehydrogenase YDL029w ACT2 actin-like protein YLR295c ATP14 F1F0-ATPase complex, subunit h YJR155w strong similarity to aryl-alcohol YOL052c SPE2 adenosylmethionine decarboxylase YEL053c MAK10 glucose-repressible protein dehydrogenase YNL138w SRV2 adenylate cyclase-associated protein, 70K YLL009c COX17 interacts genetically with SCO1 and SCO2 YFL056c strong similarity to aryl-alcohol YER170w ADK2 adenylate kinase, mitochondrial in cytochrome oxidase assembly dehydrogenases YBR109c CMD1 calmodulin YJR034w PET191 involved in assembly of cytochrome YFL057c strong similarity to aryl-alcohol YHR135c YCK1 casein kinase I isoform oxidase dehydrogenases YNL154c YCK2 casein kinase I isoform YMR165c SMP2 involved in plasmid maintenance, YOL165c strong similarity to aryl-alcohol YJL174w KRE9 cell-wall synthesis protein respiration and cell proliferation dehydrogenases YNL327w EGT2 cell-cycle regulation protein YML054c CYB2 lactate dehydrogenase cytochrome b2 YOR388c strong similarity to H. polymorpha formate YLR175w CBF5 centromere/microtubule binding protein YBR192w RIM2 mitochondrial carrier protein (MCF) dehydrogenase YGR167w CLC1 clathrin light chain YMR089c YTA12 protease of the SEC18/CDC48/PAS1 YDR251w PAM1 coiled-coil protein multicopy suppressor family of ATPases (AAA) metabolism of energy reserves (glycogen and of loss of PP2A YLR044c PDC1 pyruvate decarboxylase, isozyme 1 trehalose) YBL007c SLA1 cytoskeleton assembly control protein YGR062c COX18 required for activity of mitochondrial YFL001w DEG1 depressed growth-rate protein cytochrome oxidase YEL011w GLC3 1,4-glucan branching enzyme (glycogen YLR300w EXG1 exo-1,3-—glucanase (I/II), major isoform YBR185c MBA1 respiratory chain assembly protein branching enzyme) YDR261c EXG2 exo-1,3-—glucanase minor isoform YDL107w MSS2 ser/thr protein kinase YBR001c NTH2 α,α-trehalase YPR159w KRE6 glucan synthase subunit YPR048w similarity to M. domestica NADPH- YDR074w TPS2 α,α-trehalose-phosphate synthase, 105K YBR212w NGR1 glucose-repressible RNA-binding protein ferrihemoprotein reductase and subunit YOR043w WHI2 growth regulation protein mammalian nitric-oxide synthases YMR261c TPS3 α,α-trehalose-phosphate synthase, 115K YKL021c MAK11 involved in cell growth and replication of YGL226w similarity to N. crassa cytochrome c subunit M1 dsRNA virus oxidase subunit V YML100w TSL1 α,α-trehalose-phosphate synthase, 123K YMR165c SMP2 involved in plasmid maintenance, YMR244w similarity to NCA3 and SUN4 protein subunit respiration and cell proliferation YML087c strong similarity to cytochrome b5- and YBR126c TPS1 α,α-trehalose-phosphate synthase, 56K YNL197c WHI3 involved in regulation of cell size nitrate reductases subunit YDR293c SSD1 involved in the tolerance to high YML125c strong similarity to cytochrome b5- and YPR026w ATH1 acid trehalase, vacuolar concentration of Ca2+ nitrate reductases YBR299w MAL32 α-glucosidase YOR336w KRE5 killer toxin-resistance protein YPR004c strong similarity to electron transfer YHR047c AAP1 alanine/arginine aminopeptidase YDR480w DIG2 MAP kinase-associated protein flavoproteins α subunit YPL031c PHO85 cyclin-dependent protein kinase YJR032w CPR7 member of the cyclophilin family YOR356w strong similarity to human electron YLR071c RGR1 DNA-directed RNA polymerase II YGR029w ERV1 mitochondrial biogenesis and cell viability transfer flavoprotein-ubiquinone holoenzyme subunit protein oxidoreductase YER054c GIP2 Glc7p-interacting protein YBR089c-a NHP6B nonhistone chromosomal protein YDL085w strong similarity to NADH dehydrogenase YBR229c ROT2 glucosidase II, catalytic subunit YPR052c NHP6A nonhistone chromosomal protein related (ubiquinone) YPR160w GPH1 glycogen phosphorylase to mammalian HMG1 YMR145c strong similarity to NADH dehydrogenase YPL240c HSP82 heat-shock protein YKL203c TOR2 phosphatidylinositol 3-kinase (ubiquinone) YKL128c PMU1 high copy suppressor of ts tps2 mutant YCR034w GNS1 probable 1,3-—glucan synthase subunit YDL080c strong similarity to pyruvate phenotype YOR149c SMP3 protein kinase C pathway protein decarboxylases YDR001c NTH1 neutral trehalase (α,α-trehalase) YPL140c MKK2 protein kinase of the MAP kinase kinase YDR178w SDH4 succinate dehydrogenase membrane YMR105c PGM2 phosphoglucomutase, major isoform (MEK) family anchor subunit for Sdh2p YKL127w PGM1 phosphoglucomutase, minor isoform YDR151c CTH1 protein of the inducible CCCH zinc-finger YNL118c PSU1 suppressor protein of a yeast pet mutant YNR032w PPG1 phosphoprotein phosphatase PPG family YFR033c QCR6 ubiquinol-cytochrome c reductase 17K catalytic subunit YDR075w PPH3 protein ser/thr phosphatase protein YBL058w SHP1 potential regulatory subunit for Glc7p YDL006w PTC1 protein ser/thr phosphatase 2c YPR191w QCR2 ubiquinol-cytochrome c reductase 40K YLR273c PIG1 protein interacting with Gsy2p YDL134c PPH21 protein ser/thr phosphatase PP2A-1 subunit II YIL045w PIG2 protein interacting with Gsy2p YDL188c PPH22 protein ser/thr phosphatase PP2A-2 YBL045c COR1 ubiquinol-cytochrome c reductase 44K YJL137c GLG2 self-glucosylating initiator of glycogen YDR137w RGP1 reduced growth phenotype protein core protein synthesis YJR090c GRR1 required for glucose repression and for YHR001w-a QCR10 ubiquinol-cytochrome c reductase 8.5K YKR058w GLG1 self-glycosylating initiator of glycogen glucose and cation transport subunit synthesis YGL190c CDC55 ser/thr phosphatase 2A regulatory YGR174c CBP4 ubiquinol-cytochrome c reductase YER133w GLC7 ser/thr phosphoprotein phosphatase 1, subunit B assembly factor catalytic subunit YAL016w TPD3 ser/thr phosphatase 2A, regulatory YGL119w ABC1 ubiquinol-cytochrome c reductase YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, subunit A complex assembly protein regulatory subunit YOR231w MKK1 ser/thr protein kinase YEL024w RIP1 ubiquinol-cytochrome c reductase iron- YPR184w similarity to glycogen debranching YPR161c SGV1 ser/thr protein kinase sulphur protein enzymes YHR030c SLT2 ser/thr protein kinase of MAP kinase YDR529c QCR7 ubiquinol-cytochrome c reductase YJL221c FSP2 strong similarity to α-D-glucosidase family subunit 7 YOL157c strong similarity to α-glucosidases YJL095w BCK1 ser/thr protein kinase of the MEKK family YGR183c QCR9 ubiquinol-cytochrome c reductase YIL172c strong similarity to Fsp2p YER167w BCK2 ser/thr protein kinase of the protein subunit 9 YJL216c strong similarity to Mal62p kinase C pathway YJL166w QCR8 ubiquinol-cytochrome c reductase YFR015c GSY1 UDP glucose-starch glucosyltransferase, YNL180c similarity to S. pombe Cdc42p and other subunit VIII isoform 1 GTP-binding proteins YMR073c weak similarity to C-terminal part of YLR258w GSY2 UDP-glucose-starch glucosyltransferase, YOR027w STI1 stress-induced protein cytochrome b5 and b2 isoform 2 YGL106w strong similarity to calmodulins YNL237w YTP1 weak similarity to mitochondrial electron YKL035w UGP1 UTP-glucose-1-phosphate YER177w BMH1 strong similarity to mammalian 14-3-3 transport proteins uridylyltransferase proteins YPL032c strong similarity to Pam1p fermentation other energy-generation activities YKL161c strong similarity to ser/thr-specific protein kinase Slt2p YOL086c ADH1 alcohol dehydrogenase I YIL160c POT1 acetyl-CoA C-acyltransferase, peroxisomal YDL224c strong similarity to WHI3 protein YMR303c ADH2 alcohol dehydrogenase II YGL205w POX1 acyl-CoA oxidase YDR099w BMH2 suppressor of clathrin deficiency YMR083w ADH3 alcohol dehydrogenase III YMR170c ALD5 aldehyde dehydrogenase 2 (NAD+), YJR075w HOC1 suppressor of pkc1 YGL256w ADH4 alcohol dehydrogenase IV mitochondrial YOR075w UFE1 syntaxin (T-SNARE) of the ER YBR145w ADH5 alcohol dehydrogenase V YML035c AMD1 AMP deaminase YHR206w SKN7 transcription factor with similarity to Hsf1p YER073w aldehyde dehydrogenase (NAD+) YCR005c CIT2 citrate (si)-synthase, peroxisomal YNL079c TPM1 tropomyosin 1 YPL061w ALD6 aldehyde dehydrogenase, cytosolic YKR009c FOX2 hydratase-dehydrogenase-epimerase, YLR337w VRP1 verprolin YDL174c DLD1 D-lactate ferricytochrome c peroxisomal YLR403w SFP1 zinc-finger protein oxidoreductase (D-LCR) YMR267w PPA2 inorganic pyrophosphatase, mitochondrial YML004c GLO1 glyoxalase I YDL066w IDP1 isocitrate dehydrogenase (NADP+), budding, cell polarity and filament formation YOR126c EST2 isoamyl acetate hydrolytic enzyme mitochondrial YPL275w putative formate dehydrogenase/putative YER065c ICL1 isocitrate lyase YFL039c ACT1 actin pseudogene YKL085w MDH1 malate dehydrogenase, mitochondrial YDR129c SAC6 actin filament bundling protein, fimbrin YPL276w putative formate dehydrogenase/putative YDL078c MDH3 malate dehydrogenase, peroxisomal YCR088w ABP1 actin-binding protein pseudogene YNL117w MLS1 malate synthase 1 YDL029w ACT2 actin-like protein YDR081c PDC2 pyruvate decarboxylase regulatory protein YIR031c DAL7 malate synthase 2 YNL138w SRV2 adenylate cyclase-associated protein, 70K YLR044c PDC1 pyruvate decarboxylase, isozyme 1 YOR304c-a BAT2 AIP3 binding protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 41 gazetteer

YBL085w BOI1 BEM1 protein-binding protein YDL135c RDI1 RHO GDP dissociation inhibitor with YBR253w SRB6 DNA-directed RNA polymerase II YBR200w BEM1 bud emergence mediator activity toward Rho1p suppressor protein YPL161c BEM4 bud emergence protein YOR127w RGA1 RHO-type GTPase-activating protein for YNL053w MSG5 dual-specifity protein phosphatase YDR351w SBE2 bud growth protein Cdc42p YNL238w KEX2 endoproteinase of late Golgi YLR319c BUD6 bud site selection protein YKL181w PRPS1 ribose-phosphate pyrophosphokinase compartment YNL271c BNI1 budding protein YJR076c CDC11 septin YLR300w EXG1 exo-1,3-—glucanase (I/II), major isoform YER114c BOI2 budding protein YHR107c CDC12 septin YDR261c EXG2 exo-1,3-—glucanase minor isoform YJR092w BUD4 budding protein YGL190c CDC55 ser/thr phosphatase 2A regulatory YKL007w CAP1 F-actin capping protein, α subunit YLR353w BUD8 budding protein subunit B YIL034c CAP2 F-actin capping protein, β subunit YGR041w BUD9 budding protein YAL016w TPD3 ser/thr phosphatase 2A, regulatory YJL157c FAR1 factor arrest protein YBR109c CMD1 calmodulin subunit A YAL041w CDC24 GDP/GTP exchange factor for Cdc42p YHR135c YCK1 casein kinase I isoform YER133w GLC7 ser/thr phosphoprotein phosphatase 1, YGL097w SRM1 GDP/GTP exchange factor for YNL154c YCK2 casein kinase I isoform catalytic subunit Gsp1p/Gsp2p YPL255w BBP1 cell division control protein YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, YNL236w SIN4 global regulator protein YDR182w CDC1 cell division control protein regulatory subunit YHL025w SNF6 global transcription activator YLR314c CDC3 cell division control protein YKL048c ELM1 ser/thr protein kinase YKL104c GFA1 glucosamine-fructose-6-phosphate YFL009w CDC4 cell division control protein YOR231w MKK1 ser/thr protein kinase transaminase YJL174w KRE9 cell-wall synthesis protein YBL105c PKC1 ser/thr protein kinase YPL115c BEM3 GTPase-activating protein for Cdc42p and YBR038w CHS2 chitin synthase II YHR030c SLT2 ser/thr protein kinase of MAP kinase Rho1p YBR023c CHS3 chitin synthase III family YHR005c GPA1 GTP-binding protein α subunit of the YLR330w CHS5 chitin synthesis protein YJL095w BCK1 ser/thr protein kinase of the MEKK family pheromone pathway YLL050c COF1 cofilin, actin binding and severing protein YLR362w STE11 ser/thr protein kinase of the MEKK family YOR212w STE4 GTP-binding protein β subunit of the YDR251w PAM1 coiled-coil protein multicopy suppressor YER167w BCK2 ser/thr protein kinase of the protein pheromone pathway of loss of PP2A kinase C pathway YJR086w STE18 GTP-binding protein γ subunit of the YPL256c CLN2 cyclin, G1/S specific YDL159w STE7 ser/thr/tyr protein kinase of MAP kinase pheromone pathway YBR160w CDC28 cyclin-dependent protein kinase kinase family YLR229c CDC42 GTP-binding protein of RAS superfamily YNL243w SLA2 cytoskeleton assembly control protein YDL225w similarity to Cdc11p, Cdc3p and human YNL173c MDG1 GTP-binding protein of the pheromone YLR071c RGR1 DNA-directed RNA polymerase II CDC10 protein pathway holoenzyme subunit YGL054c similarity to D. melanogaster cni protein YER020w GPA2 guanine nucleotide-binding regulatory YKL007w CAP1 F-actin capping protein, α subunit YCR009c RVS161 similarity to human amphiphysin and protein YIL034c CAP2 F-actin capping protein, β subunit Rvs167p YDL227c HO homothallic switching endonuclease YJL157c FAR1 factor arrest protein YDR208w MSS4 similarity to human PI P 5-kinase YNL291c MID1 involved in Ca2+ influx during mating YAL041w CDC24 GDP/GTP exchange factor for Cdc42p YDR409w similarity to Nfi1p YLL021w SPA2 involved in cell polarity YCR038c BUD5 GDP/GTP exchange factor for YDL125c YHI1 similarity to protein kinase C inhibitor-I YLR452c SST2 involved in desensitization to α-factor Rsr1p/Bud1p YDR245w MNN10 similarity to S. pombe pheromone YGR070w ROM1 GDP/GTP exchange protein for Rho1p galactosyltransferase YDR085c AFR1 involved in morphogenesis of the mating YLR371w ROM2 GDP/GTP exchange protein for Rho1p YFR040w SAP155 Sit4p-associated protein projection YGL155w CDC43 geranylgeranyltransferase type I β subunit YKR028w SAP190 Sit4p-associated protein YER149c PEA2 involved in oriented growth toward mating YER155c BEM2 GTPase-activating protein YJL098w SAP185 Sit4p-associating protein partner YKL092c BUD2 GTPase-activating protein for YLR372w SUR4 sterol isomerase YMR052w FAR3 involved in pheromone-mediated cell Bud1p/Rsr1p YHR103w SBE22 strong similarity to budding protein Sbe2p cycle arrest YPL115c BEM3 GTPase-activating protein for Cdc42p and YGL106w strong similarity to calmodulins YMR127c SAS2 involved in silencing at HMR Rho1p YBR210w strong similarity to D. melanogaster YPR141c KAR3 kinesin-related protein YGR152c RSR1 GTP-binding protein cornichon protein YPL187w MFα1 mating pheromone α-1 factor YLR229c CDC42 GTP-binding protein of RAS superfamily YPL032c strong similarity to Pam1p YGL089c MFα2 mating pheromone α-2 factor YIL118w RHO3 GTP-binding protein of the RHO family YNL320w strong similarity to S. pombe Bem46p YDR461w MFA1 mating pheromone a-factor 1 YKR055w RHO4 GTP-binding protein of the RHO family YKL161c strong similarity to ser/thr-specific protein YNL145w MFA2 mating pheromone a-factor 2 YPR165w RHO1 GTP-binding protein of the RHO subfamily kinase Slt2p YLR332w MID2 mating process protein of RAS-like proteins YBR161w strong similarity to Sur1p YHR066w SSF1 mating protein YNL090w RHO2 GTP-binding protein of the RHO subfamily YJR075w HOC1 suppressor of pkc1 YDR143c SAN1 mating type regulatory protein of RAS-like proteins YDR297w SUR2 suppressor of rvs161 and rvs167 YCR040w MATα1 mating type regulatory protein (expressed YOR156c NFI1 interacts with Cdc12p in 2-hybrid assay mutations copy at MAT locus) YKR063c LAS1 involved in cell morphogenesis, YPL057c SUR1 suppressor of rvs161, rvs167, and cls2 YCR039c MATα2 mating type regulatory protein (expressed cytoskeletal regulation and bud formation mutations copy at MAT locus) YLL021w SPA2 involved in cell polarity YKL043w PHD1 transcription factor YCL066w α1 mating type regulatory protein (silenced YDR085c AFR1 involved in morphogenesis of the mating YGL181w GTS1 transcription factor of the copy at HML locus) projection Gcs1p/Glo3p/Sps18p family YCL067c α2 mating type regulatory protein (silenced YMR273c ZDS1 involved in negative regulation of cell YHR084w STE12 transcriptional activator copy at HML locus) polarity YNL079c TPM1 tropomyosin 1 YCR097w A1 mating type regulatory protein (silenced YER149c PEA2 involved in oriented growth towards YIL138c TPM2 tropomyosin 2 copy at HMR locus) mating partner YBR083w TEC1 Ty transcription activator YCR096c A2 mating type regulatory protein (silenced YDR293c SSD1 involved in the tolerance to high YGL095c VPS45 vacuolar protein sorting-associated copy at HMR locus) concentration of Ca2+ protein YIL047c SYG1 member of the major facilitator YKL079w SMY1 kinesin-related protein YLR337w VRP1 verprolin superfamily YOR198c BFR1 maintenance of normal ploidy YBL016w FUS3 mitogen-activated protein kinase (MAP YJL158c member of the Pir1p/Hsp150p/Pir3p pheromone response and mating-type kinase) family determination YGL151w NUT1 negative regulator of HO endonuclease YJL159w member of the Pir1p/Hsp150p/Pir3p YPR168w NUT2 negative regulator of HO endonuclease family YJR004c SAG1 α-agglutinin YKL185w ASH1 negative regulator of HO expression YJL160c member of the Pir1p/Hsp150p/Pir3p YNR044w AGA1 α-agglutinin anchor subunit YCL029c BIK1 nuclear fusion protein family YGL032c AGA2 α-agglutinin binding subunit YML065w ORC1 origin recognition complex, 104K subunit YOR188w MSB1 morphogenesis-related protein YDR264c AKR1 ankyrin repeat-containing protein YNL261w ORC5 origin recognition complex, 50K subunit YGR014w MSB2 multicopy suppressor of a cdc24 bud YKL209c STE6 ATP-binding cassette transporter protein YHR118c ORC6 origin recognition complex, 50K subunit emergence defect YIL015w BAR1 barrier pepsin YPR162c ORC4 origin recognition complex, 56K subunit YHR023w MYO1 myosin 1 isoform (type II myosin) heavy YBR200w BEM1 bud emergence mediator YLL004w ORC3 origin recognition complex, 62K subunit chain YPL161c BEM4 bud emergence protein YBR060c RRR1 origin recognition complex, 72K subunit YOR326w MYO2 myosin heavy chain YML057w CMP2 calcineurin B, catalytic subunit YFL026w STE2 pheromone α-factor receptor YAL029c MYO4 myosin heavy chain, unconventional YLR433c CNA1 calcineurin B, catalytic subunit YKL178c STE3 pheromone α-factor receptor (class V) isoform YKL190w CNB1 calcineurin B, regulatory subunit YCL032w STE50 pheromone response pathway protein YMR109w MYO5 myosin I YBR109c CMD1 calmodulin YDR103w STE5 pheromone signal transduction pathway YKL129c MYO3 myosin type I YCR002c CDC10 cell division control protein protein YBR089c-a NHP6B nonhistone chromosomal protein YLR314c CDC3 cell division control protein YCR034w GNS1 probable 1,3-—glucan synthase subunit YPR052c NHP6A nonhistone chromosomal protein related YNL188w KAR1 cell division control protein YLR389c STE23 protease involved in α-factor processing to mammalian HMG1 YCL027w FUS1 cell fusion protein YML032c RAD52 recombination and DNA repair protein YCR057c PWP2 periodic tryptophan protein YJL174w KRE9 cell-wall synthesis protein YDR392w SPT3 regulatory protein YBL058w SHP1 potential regulatory subunit for Glc7p YNL192w CHS1 chitin synthase I YCL055w KAR4 regulatory protein required for pheromone YCR034w GNS1 probable 1,3-—glucan synthase subunit YBR023c CHS3 chitin synthase III induction of karyogamy genes YER108c FLO8 probable transcriptional activator of Flo1p YLR330w CHS5 chitin synthesis protein YMR232w FUS2 required for cell fusion during mating YOR122c PFY1 profilin YDR073w SNF11 component of SWI/SNF transcription YBR040w FIG1 required for efficient mating YPR122w AXL1 protease activator complex YCR089w FIG2 required for efficient mating YOR149c SMP3 protein kinase C pathway protein YOR290c SNF2 component of SWI/SNF transcription YNL084c END3 required for endocytosis and cytoskeletal YPL140c MKK2 protein kinase of the MAP kinase kinase activator complex organization (MEK) family YBR289w SNF5 component of SWI/SNF transcription YKL130c SHE2 required for mother cell-specific YDL047w SIT4 protein ser/thr phosphatase activator complex expression of HO YDL006w PTC1 protein ser/thr phosphatase 2c YPL016w SWI1 component of SWI/SNF transcription YOR035c SHE4 required for mother cell-specific gene YDL134c PPH21 protein ser/thr phosphatase PP2A-1 activator complex expression YDL188c PPH22 protein ser/thr phosphatase PP2A-2 YPL256c CLN2 cyclin, G1/S specific YOR127w RGA1 RHO-type GTPase-activating protein for YDR388w RVS167 reduced viability upon starvation protein YNL243w SLA2 cytoskeleton assembly control protein Cdc42p YMR016c SOK2 regulatory protein in the PKA signal YER095w RAD51 DNA repair protein YLR441c RP10A ribosomal protein S3a.e transduction pathway YDR076w RAD55 DNA repair protein YJR076c CDC11 septin YCL014w BUD3 required for axial budding YDR004w RAD57 DNA repair protein YHR107c CDC12 septin YIL140w SRO4 required for axial pattern of budding YAR007c RFA1 DNA replication factor A, 69K subunit YPR161c SGV1 ser/thr protein kinase YER109c FLO8 required for diploid filamentous growth YOL051w GAL11 DNA-directed RNA polymerase II YGR040w KSS1 ser/thr protein kinase of the MAP kinase YNL084c END3 required for endocytosis and cytoskeletal holoenzyme and Kornberg’s mediator family organization (SRB) subcomplex subunit YLR362w STE11 ser/thr protein kinase of the MEKK family YJR090c GRR1 required for glucose repression and for YLR071c RGR1 DNA-directed RNA polymerase II YHL007c STE20 ser/thr protein kinase of the pheromone glucose and cation transport holoenzyme subunit pathway

42 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YDL159w STE7 ser/thr/tyr protein kinase of MAP kinase YBR078w strong similarity to sporulation-specific YJR094c IME1 transcription factor required for kinase family Sps2p sporulation YOL068c HST1 silencing protein YCL048w strong similarity to sporulation-specific YGR044c RME1 zinc-finger transcription factor YBL052c SAS3 silencing protein Sps2p YKR101w SIR1 silencing regulatory protein YDR055w strong similarity to Sps2p DNA synthesis and replication YDL042c SIR2 silencing regulatory protein YOR075w UFE1 syntaxin (T-SNARE) of the ER YLR442c SIR3 silencing regulatory protein YMR043w MCM1 transcription factor of the MADS box YKL112w ABF1 ARS-binding factor YDR227w SIR4 silencing regulatory protein family YFL009w CDC4 cell division control protein YNL283c similarity to a-agglutinin core protein YJR094c IME1 transcription factor required for YDR364c CDC40 cell division control protein Aga1p sporulation YLR274w CDC46 cell division control protein YDL225w similarity to Cdc11p, Cdc3p and human YNL330c RPD3 transcription modifier protein YBR202w CDC47 cell division control protein CDC10 protein YOL004w SIN3 transcription regulatory protein YJL194w CDC6 cell division control protein YDR191w HST4 similarity to Hst3p,Hst1p and Sir2p YNL012w SPO1 transcriptional regulator involved in YML102w CAC2 chromatin assembly complex, subunit YGR023w similarity to Mid2p sporulation YBR195c MSI1 chromatin assembly complex, subunit YHR146w similarity to pheromone-response G- YLL039c UBI4 ubiquitin p50 protein YNL173c YGL058w RAD6 ubiquitin-conjugating enzyme YPR018w RLF2 chromatin assembly complex, subunit YKL117w Ste5p-associated protein YDR177w UBC1 ubiquitin-conjugating enzyme p90 YGL106w strong similarity to calmodulins YER125w RSP5 ubiquitin-protein ligase YPR120c CLB5 cyclin, B-type YJL212c strong similarity to S. pombe isp4 protein YML115c VAN1 vanadate resistance protein YGR109c CLB6 cyclin, B-type YDR312w SSF2 strong similarity to SSF1 protein YPL256c CLN2 cyclin, G1/S specific YPL129w ANC1 TFIIF subunit (transcription initiation meiosis YBR160w CDC28 cyclin-dependent protein kinase factor), 30K YER176w DNA dependent ATPase/DNA helicase B YDR146c SWI5 transcription factor YPR103w PRE2 26S proteasome subunit YHR164c DNA2 DNA helicase YMR043w MCM1 transcription factor of the MADS box YGR253c PUP2 26S proteasome subunit YDL164c CDC9 DNA ligase family YKL112w ABF1 ARS-binding factor YJL173c RFA3 DNA replication factor A, 13K subunit YNL330c RPD3 transcription modifier protein YFL037w TUB2 β-tubulin YNL312w RFA2 DNA replication factor A, 36K subunit YOL004w SIN3 transcription regulatory protein YOR265w RBL2 β-tubulin binding protein YAR007c RFA1 DNA replication factor A, 69K subunit YJL176c SWI3 transcription regulatory protein YPL204w HRR25 casein kinase I, ser/thr/tyr protein kinase YOL094c RFC4 DNA replication factor C, 37K subunit YHR084w STE12 transcriptional activator YBR136w ESR1 cell cycle checkpoint protein YNL290w RFC3 DNA replication factor C, 40K subunit YER068w MOT2 transcriptional repressor YPL255w BBP1 cell division control protein YBR087w RFC5 DNA replication factor C, 40K subunit YNL079c TPM1 tropomyosin 1 YDL220c CDC13 cell division control protein YJR068w RFC2 DNA replication factor C, 41K subunit YOR219c STE13 type IV dipeptidyl aminopeptidase YPL042c SSN3 cyclin-dependent ser/thr protein kinase YOR217w RFC1 DNA replication factor C, 95K subunit YMR022w QRI8 ubiquitin-conjugating enzyme YOR368w RAD17 DNA damage checkpoint control protein YJR006w HUS2 DNA replication protein YBR082c UBC4 ubiquitin-conjugating enzyme YMR224c MRE11 DNA repair and meiotic recombination YOL006c TOP1 DNA topoisomerase I YDR059c UBC5 ubiquitin-conjugating enzyme protein YNL088w TOP2 DNA topoisomerase II (ATP-hydrolysing) YER100w UBC6 ubiquitin-conjugating enzyme YNL250w RAD50 DNA repair protein YNL102w CDC17 DNA-directed DNA polymerase α, 180K YJR117w STE24 zinc metallo-protease YDR076w RAD55 DNA repair protein subunit YDR004w RAD57 DNA repair protein YIR008c PRI1 DNA-directed DNA polymerase α, 48K sporulation and germination YDR369c XRS2 DNA repair protein subunit (DNA primase) YLR234w TOP3 DNA topoisomerase III YKL045w PRI2 DNA-directed DNA polymerase α, 58K YGR032w GSC2 1,3-—D-glucan synthase, subunit YGL163c RAD54 DNA-dependent ATPase of the Snf2p subunit (DNA primase) YPR103w PRE2 26S proteasome subunit family YPR135w POB1 DNA-directed DNA polymerase α-binding YGR253c PUP2 26S proteasome subunit YNL025c SSN8 DNA-directed RNA polymerase II protein YBL015w ACH1 acetyl-CoA hydrolase holoenzyme and Kornberg’s mediator YDL102w CDC2 DNA-directed DNA polymerase δ, YCR048w ARE1 acyl-CoA sterol acyltransferase (SRB) subcomplex subunit, cyclin C catalytic 125K subunit YNR019w ARE2 acyl-CoA sterol acyltransferase homolog YNL262w POL2 DNA-directed DNA polymerase ε, catalytic YOL052c SPE2 adenosylmethionine decarboxylase YKL017c DIP1 Dom34p Interacting Protein subunit A YDR173c ARG82 arginine metabolism transcription factor YLR129w DIP2 Dom34p-interacting protein YPR175w DPB2 DNA-directed DNA polymerase ε, subunit YIL033c SRA1 cAMP dependent protein kinase, YBR045c GIP1 Glc7-interacting protein B regulatory subunit YPL240c HSP82 heat-shock protein YBR278w DPB3 DNA-directed DNA polymerase ε, subunit YDR182w CDC1 cell division control protein YJL146w IDS2 IME2-dependent signaling protein C YFL009w CDC4 cell division control protein YOR198c BFR1 maintenance of normal ploidy YOR330c MIP1 DNA-directed DNA polymerase γ, catalytic YNL192w CHS1 chitin synthase I YHL022c SPO11 meiosis-specific protein subunit, mitochondrial YBR023c CHS3 chitin synthase III YER179w DMC1 meiosis-specific protein YPL167c REV3 DNA-directed DNA polymerase ζ YDR402c DIT2 cytochrome P450 56 YIL072w HOP1 meiosis-specific protein YFL036w RPO41 DNA-directed RNA polymerase, YML110c DBI56 DBF2 interacting protein YER180c ISC10 meiosis-specific protein mitochondrial YOL051w GAL11 DNA-directed RNA polymerase II YER044c-a MEI4 meiosis-specific protein YMR072w ABF2 high-mobility group protein holoenzyme and Kornberg’s mediator YDL154w MSH5 meiosis-specific protein YJL090c DPB11 involved in DNA replication and S-phase (SRB) subcomplex subunit YHR124w NDT80 meiosis-specific protein checkpoint YBR253w SRB6 DNA-directed RNA polymerase II YHR157w REC104 meiosis-specific protein YDR068w DOS1 involved in genome stability suppressor protein YLR263w RED1 meiosis-specific protein YMR001c CDC5 involved in regulation of DNA replication YMR013c SEC59 dolichol kinase YHR079c-a SAE3 meiosis-specific protein YPR019w CDC54 member of the Cdc46p/Mcm2p/Mcm3p YOR190w SPR1 exo-1,3-—glucanase YHR014w SPO13 meiosis-specific protein family YLR300w EXG1 exo-1,3-—glucanase (I/II), major isoform YPL121c MEI5 meiotic protein YBL023c MCM2 member of the Mcm2p,Mcm3p,Cdc46p YDR261c EXG2 exo-1,3-—glucanase minor isoform YBR057c MUM2 meiotic protein family YBR045c GIP1 Glc7p-interacting protein YAL009w SPO7 meiotic protein YML065w ORC1 origin recognition complex, 104K subunit YNL236w SIN4 global regulator protein YNL210w MER1 meiotic recombination protein YNL261w ORC5 origin recognition complex, 50K subunit YDL240w LRG1 GTPase-activating protein of the YHR086w NAM8 meiotic recombination protein YHR118c ORC6 origin recognition complex, 50K subunit RHO/RAC family YLR329w REC102 meiotic recombination protein YPR162c ORC4 origin recognition complex, 56K subunit YNL098c RAS2 GTP-binding protein YJR021c REC107 meiotic recombination protein YLL004w ORC3 origin recognition complex, 62K subunit YPL240c HSP82 heat-shock protein YMR133w REC114 meiotic recombination protein YBR060c RRR1 origin recognition complex, 72K subunit YJL146w IDS2 IME2-dependent signaling protein YGL175c SAE2 meiotic recombination protein YGR132c PHB1 prohibitin, antiproliferative protein YER044c-a MEI4 meiosis-specific protein YHL027w RIM101 meiotic regulatory protein YBR088c POL30 proliferating cell nuclear antigen (PCNA) YBR057c MUM2 meiotic protein YDR207c UME6 negative transcriptional regulator YDL017w CDC7 protein kinase YAL009w SPO7 meiotic protein YBL058w SHP1 potential regulatory subunit for Glc7p YFR028c CDC14 protein-tyrosine-phosphatase YLR025w SNF7 nuclear protein YMR076c PDS5 precocious dissociation of sister YDR052c DBF4 regulatory subunit for Cdc7p protein YKR031c SPO14 phospholipase D chromatids kinase YGL192w IME4 positive transcription factor for IME2 YDL017w CDC7 protein kinase YEL032w MCM3 replication initiation protein YCR034w GNS1 probable 1,3-—glucan synthase subunit YIR026c YVH1 protein tyrosine phosphatase YIL139c REV7 required for DNA damage-induced YIR026c YVH1 protein tyrosine phosphatase YOR208w PTP2 protein tyrosine phosphatase mutagenesis YOR208w PTP2 protein-tyrosine-phosphatase YBR073w RDH54 required for meiosis YLR103c CDC45 required for minichromosome YBL066c SEF1 putative transcription factor YER133w GLC7 ser/thr phosphoprotein phosphatase 1, maintenance and initiation of YNR052c POP2 required for glucose derepression catalytic subunit chromosomal DNA replication YDR218c SPR28 septin-related sporulation protein YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, YIL150c DNA43 required for S-phase initiation or YJL106w IME2 ser/thr protein kinase regulatory subunit completion YDR523c SPS1 ser/thr protein kinase YJL106w IME2 ser/thr protein kinase YER070w RNR1 ribonucleoside-diphosphate reductase, YNL307c MCK1 ser/thr/tyr protein kinase YMR139w MDS1 ser/thr protein kinase large subunit YDR403w DIT1 spore-wall maturation protein YOR351c MEK1 ser/thr protein kinase YJL026w RNR2 ribonucleoside-diphosphate reductase, YBR148w YSW1 spore-specific protein YDR523c SPS1 ser/thr protein kinase small subunit YKL165c sporulation protein YNL307c MCK1 ser/thr/tyr protein kinase YIL066c RNR3 ribonucleotide reductase, repair inducible YLR399c BDF1 sporulation protein YDL028c MPS1 ser/thr/tyr protein kinase YJL065c similarity to DNA-directed DNA YHR152w SPO12 sporulation protein YNL001w DOM34 similarity to D. melanogaster pelota polymerase II subunit C YHR153c SPO16 sporulation protein protein YDR206w similarity to EST1 protein YIL099w SGA1 sporulation specific glucan YFL003c MSH4 similarity to MSH proteins YOR005c similarity to human mRNA for DNA ligase 1,4-—glucosidase YHR152w SPO12 sporulation protein IV YDR108w GSG1 sporulation-specific protein YHR153c SPO16 sporulation protein YOL095c similarity to S. aureus DNA helicase YER096w SHC1 sporulation-specific protein YDR108w GSG1 sporulation-specific protein PCRA YLR307w CDA1 sporulation-specific chitin deacetylase YNL202w SPS19 sporulation-specific protein YGL201c similarity with rat intestinal DNA YLR308w CDA2 sporulation-specific chitin deacetylase YDR522c SPS2 sporulation-specific protein replication protein YPR054w SMK1 sporulation-specific MAP kinase YNL204c SPS18 sporulation-specific zinc-finger protein YKL113c RAD27 ssDNA endonuclease and YER115c SPR6 sporulation-specific protein YBR078w strong similarity to sporulation-specific 5’-3’exonuclease YNL202w SPS19 sporulation-specific protein Sps2p YCR028c-a RIM1 ssDNA-binding protein, mitochondrial YDR522c SPS2 sporulation-specific protein YCL048w strong similarity to sporulation-specific YGR231c strong similarity to prohibitins YOR313c SPS4 sporulation-specific protein Sps2p YBL035c POL12 subunit of DNA polymerase α-primase YGR059w SPR3 sporulation-specific septin YDR055w strong similarity to Sps2p complex YHR139c SPS100 sporulation-specific wall maturation YGR258c RAD2 structure-specific nuclease of the YLR233c EST1 telomere elongation protein protein nucleotide excision repairosome YCR077c (PAT1) topoisomerase II-associated protein YNL204c SPS18 sporulation-specific zinc-finger protein YDR285w ZIP1 synaptonemal complex protein YOL115w TRF4 topoisomerase I-related protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 43 gazetteer

YLR182w SWI6 transcription factor YOR026w BUB3 cell-cycle arrest protein YGR140w CBF2 kinetochore protein complex CBF3, 110K YDR054c CDC34 ubiquitin-conjugating enzyme YPL178w SAE1 cell-cycle block in meiotic prophase subunit YGL058w RAD6 ubiquitin-conjugating enzyme YBR136w ESR1 cell-cycle checkpoint protein YMR094w CTF13 kinetochore protein complex CBF3, 58K YPR111w DBF20 cell-cycle protein kinase related to Dbf2p subunit recombination and DNA repair YDR113c PDS1 cell-cycle regulator YMR168c CEP3 kinetochore protein complex CBF3, 71K YBR215w HPC2 cell-cycle regulatory protein subunit YGL127c SOH1 allows hpr1 null mutant to grow at 37ºC YOR373w NUD1 cell-cycle regulatory protein YDR328c SKP1 kinetochore protein complex CBF3, YBR136w ESR1 cell-cycle checkpoint protein YPL255w BBP1 cell division control protein subunit D YER173w RAD24 cell-cycle checkpoint protein YDR182w CDC1 cell division control protein YOR198c BFR1 maintenance of normal ploidy YDR182w CDC1 cell-division control protein YCR002c CDC10 cell division control protein YLR332w MID2 mating process protein YMR106c HDF2 component of DNA end-joining repair YDL220c CDC13 cell division control protein YER179w DMC1 meiosis-specific protein pathway YGL116w CDC20 cell division control protein YHR079c-a SAE3 meiosis-specific protein YKL011c CCE1 cruciform-cutting endonuclease, YLR314c CDC3 cell division control protein YPR019w CDC54 member of the Cdc46p/Mcm2p/Mcm3p mitochondrial YDR168w CDC37 cell division control protein family YER176w DNA-dependent ATPase/DNA helicase B YFL009w CDC4 cell division control protein YDL126c CDC48 microsomal protein of YLR032w RAD5 DNA helicase YDR364c CDC40 cell division control protein CDC48/PAS1/SEC18 family of ATPases YMR190c SGS1 DNA helicase YLR274w CDC46 cell division control protein YOR058c ASE1 microtubule-associated protein YML061c PIF1 DNA helicase involved in mitochondrial YBR202w CDC47 cell division control protein YNL064c YDJ1 mitochondrial and ER import protein DNA repair and telomere length YJL194w CDC6 cell division control protein YGR029w ERV1 mitochondrial biogenesis and regulation YDL164c CDC9 DNA ligase YNL188w KAR1 cell division control protein of cell cycle YMR167w MLH1 DNA mismatch repair protein YDL226c GCS1 cell proliferation zinc-finger protein YBL016w FUS3 mitogen-activated protein kinase (MAP YOL090w MSH2 DNA mismatch repair protein YNL327w EGT2 cell-cycle regulation protein kinase) YNL082w PMS1 DNA mismatch repair protein YHR129c ACT5 centractin YMR294w JNM1 mitosis protein, involved in nuclear YHR120w MSH1 DNA mismatch repair protein, YLR175w CBF5 centromere/microtubule binding protein migration mitochondrial YDR254w CHL4 chromosome segregation protein YMR036c MIH1 M-phase inducing protein tyrosine YCR014c POL4 DNA polymerase YOR349w CIN1 chromosome segregation protein phosphatase YMR224c MRE11 DNA repair and meiotic recombination YFL008w SMC1 chromosome segregation protein YGL178w MPT5 multicopy suppressor of pop2 protein YFR031c SMC2 chromosome segregation protein YML109w ZDS2 multicopy suppressor of sin4 YJR035w RAD26 DNA repair and recombination protein YMR028w TAP42 component of the Tor signalling pathway YGL173c KEM1 multifunctional nuclease YEL019c MMS21 DNA repair protein YIL106w MOB1 conditional mutants arrest in late mitosis YDR207c UME6 negative transcriptional regulator YML095c RAD10 DNA repair protein YDL132w CDC53 controls G1/S transition YBL020w RFT1 nuclear division protein YCR066w RAD18 DNA repair protein YPR120c CLB5 cyclin, B-type YNL299w TRF5 nuclear division protein YNL250w RAD50 DNA repair protein YGR109c CLB6 cyclin, B-type YML031w NDC1 nuclear envelope protein YER095w RAD51 DNA repair protein YMR199w CLN1 cyclin, G1/S specific YJR112w NNF1 nuclear envelope protein YDR076w RAD55 DNA repair protein YPL256c CLN2 cyclin, G1/S specific YCL029c BIK1 nuclear fusion protein YDR004w RAD57 DNA repair protein YAL040c CLN3 cyclin, G1/S specific YJL034w KAR2 nuclear fusion protein YDR369c XRS2 DNA repair protein YNL289w PCL1 cyclin, G1/S specific YDR150w NUM1 nuclear migration protein YAR007c RFA1 DNA replication factor A, 69K subunit YDL127w PCL2 cyclin, G1/S specific YAL025c MAK16 nuclear viral propagation protein YOL006c TOP1 DNA topoisomerase I YGR108w CLB1 cyclin, G2/M-specific YKR048c NAP1 nucleosome assembly protein I YNL088w TOP2 DNA topoisomerase II (ATP-hydrolysing) YPR119w CLB2 cyclin, G2/M-specific YLR079w SIC1 p40 inhibitor of Cdc28p-Clb protein kinase YGL163c RAD54 DNA-dependent ATPase of the Snf2p YDL155w CLB3 cyclin, G2/M-specific complex family YLR210w CLB4 cyclin, G2/M-specific YJR066w TOR1 phosphatidylinositol 3-kinase YFR023w PES4 DNA-directed DNA polymerase ε YBR135w CKS1 cyclin-dependent kinase regulatory YKL203c TOR2 phosphatidylinositol 3-kinase suppressor subunit YLR305c STT4 phosphatidylinositol-4-kinase YPL167c REV3 DNA-directed DNA polymerase ζ YBR160w CDC28 cyclin-dependent protein kinase YCL004w PEL1 phosphatidylserine synthase YCR092c MSH3 DNA-repair protein YPL031c PHO85 cyclin-dependent protein kinase YBL058w SHP1 potential regulatory subunit for Glc7p YKR056w RNC1 endo-exonuclease YDL108w KIN28 cyclin-dependent ser/thr protein kinase YGL238w CSE1 probable kinetochore protein YOR033c DHS1 exonuclease, interacting with Msh2p YGL215w CLG1 cyclin-like protein YGR132c PHB1 prohibitin, antiproliferative protein YLR288c MEC3 G2-specific checkpoint protein YOR368w RAD17 DNA damage checkpoint control protein YDL017w CDC7 protein kinase YMR284w HDF1 high-affinity DNA-binding protein YDR217c RAD9 DNA repair checkpoint protein YOR149c SMP3 protein kinase C pathway protein YDR138w HPR1 hyperrecombination protein related to YOR217w RFC1 DNA replication factor C, 95K subunit YPL140c MKK2 protein kinase of the MAP kinase kinase Top1p YLR234w TOP3 DNA topoisomerase III (MEK) family YHL022c SPO11 meiosis-specific protein YKL017c DIP1 Dom34p-interacting protein YAR019c CDC15 protein kinase of the MAP kinase kinase YER179w DMC1 meiosis-specific protein YLR129w DIP2 Dom34p-interacting protein kinase family YIL072w HOP1 meiosis-specific protein YNL053w MSG5 dual-specifity protein phosphatase YHR013c ARD1 protein N-acetyltransferase subunit YHR157w REC104 meiosis-specific protein YKR054c DYN1 dynein heavy chain, cytosolic YPL008w CHL1 protein of the DEAH box family YLR263w RED1 meiosis-specific protein YDR172w SUP35 eukaryotic peptide chain release factor YDL047w SIT4 protein ser/thr phosphatase YPL121c MEI5 meiotic protein GTP-binding subunit YDL134c PPH21 protein ser/thr phosphatase PP2A-1 YNL210w MER1 meiotic recombination protein YNL292w EXM1 exit from mitosis YDL188c PPH22 protein ser/thr phosphatase PP2A-2 YHR086w NAM8 meiotic recombination protein YDL087c EXM2 exit from mitosis YBR267w PPS1 protein tyrosine phosphatase YLR329w REC102 meiotic recombination protein YJL157c FAR1 factor arrest protein YFR028c CDC14 protein-tyrosine-phosphatase YJR021c REC107 meiotic recombination protein YLR212c TUB4 γ tubulin YOL021c DIS3 Ran binding protein YGL175c SAE2 meiotic recombination protein YLR288c MEC3 G2-specific checkpoint protein YDR137w RGP1 reduced growth phenotype protein YBR114w RAD16 nucleotide excision repair protein YAL024c LTE1 GDP/GTP exchange factor YDR052c DBF4 regulatory subunit for Cdc7p protein YGL025c PGD1 probable transcription factor YLL016w SDC25 GDP/GTP exchange factor kinase YBR088c POL30 proliferating cell nuclear antigen (PCNA) YAL041w CDC24 GDP/GTP exchange factor for Cdc42p YKL193c SDS22 regulatory subunit for the mitotic function YML032c RAD52 recombination and DNA repair protein YLR310c CDC25 GDP/GTP exchange factor for Ras1p and of type I protein phosphatase YDL059c RAD59 recombination and DNA repair protein Ras2p YMR078c CHL12 required for accurate chromosome YLR383w RHC18 recombination repair protein YGL207w SPT16 general chromatin factor transmission in mitosis and maintenance YBR073w RDH54 required for meiosis YGL155w CDC43 geranylgeranyltransferase type I β subunit of normal telomere length YIL066c RNR3 ribonucleotide reductase, repair inducible YER155c BEM2 GTPase-activating protein YOL145c CTR9 required for G1 cyclin expression YMR228w MTF1 RNA polymerase specific factor, YMR138w CIN4 GTP-binding protein YLR103c CDC45 required for minichromosome mitochondrial YNL098c RAS2 GTP-binding protein maintenance and initiation of YOR351c MEK1 ser/thr protein kinase YLR229c CDC42 GTP-binding protein of RAS superfamily chromosomal DNA replication YPL164c similarity to mismatch repair protein YML064c TEM1 GTP-binding protein of the RAS YKL089w MIF2 required for normal chromosome Mlh1p superfamily segregation and spindle integrity YOR077w RTS2 similarity to mouse KIN17 protein YNL007c SIS1 heat-shock protein YGR098c ESP1 required for normal spindle structure YFL003c MSH4 similarity to MSH proteins YBR133c HSL7 histone synthetic lethality YIL150c DNA43 required for S-phase initiation or YDR097c MSH6 similarity to MSH proteins YJL080c SCP160 histone-like protein completion YHR031c similarity to Pif1p YOL076w DEC1 interacts genetically with CIN8 YJL074c SMC3 required for structural maintenance of YGL043w DST1 TFIIS (transcription elongation factor) YOR156c NFI1 interacts with Cdc12p in 2-hybrid assay chromosomes YCR077c (PAT1) topoisomerase II-associated protein YNR010w CSE2 interacts with centromeric element CDEII YGR078c PAC10 required in the absence of Cin8p YGR063c SPT4 transcription initiation protein YML104c MDM1 intermediate filament protein YDR488c PAC11 required in the absence of Cin8p YGR116w SPT6 transcription initiation protein YKR072c SIS2 involved in cell cycle-specific gene YLR075w GRC5 ribosomal protein YML021c UNG1 uracil-DNA glycosylase expression YJR076c CDC11 septin YKR063c LAS1 involved in cell morphogenesis, YHR107c CDC12 septin cell-cycle control and mitosis cytoskeletal regulation and bud formation YAL016w TPD3 ser/thr phosphatase 2A, regulatory YPL241c CIN2 involved in chromosome segregation subunit A YFR052w NIN1 26S proteasome regulatory subunit YPL018w CTF19 involved in chromosome segregation YER133w GLC7 ser/thr phosphoprotein phosphatase 1, YPR103w PRE2 26S proteasome subunit YJL090c DPB11 involved in DNA replication and S-phase catalytic subunit YGL048c SUG1 26S proteasome subunit checkpoint YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, YKL145w YTA3 26S proteasome subunit YMR273c ZDS1 involved in negative regulation of cell regulatory subunit YJL005w CYR1 adenylate cyclase polarity YGR188c BUB1 ser/thr protein kinase YPL239w YAR1 ankyrin repeat-containing protein YMR052w FAR3 involved in pheromone-mediated cell YKL048c ELM1 ser/thr protein kinase YHR101c BIG1 big cells phenotype cycle arrest YJL106w IME2 ser/thr protein kinase YHR208w TWT1 branched-chain amino-acid YMR052w FAR3 involved in pheromone-mediated cell YPL209c IPL1 ser/thr protein kinase aminotransferase, mitochondrial cycle arrest YOR231w MKK1 ser/thr protein kinase YFL037w TUB2 β-tubulin YMR001c CDC5 involved in regulation of DNA replication YBL105c PKC1 ser/thr protein kinase YBR200w BEM1 bud emergence mediator YMR127c SAS2 involved in silencing at HMR YPR161c SGV1 ser/thr protein kinase YBR109c CMD1 calmodulin YKR042w UTH1 involved in the aging process YJL141c YAK1 ser/thr protein kinase YOR061w CKA2 casein kinase II α‘ subunit YDR293c SSD1 involved in the tolerance to high YMR104c YPK2 ser/thr protein kinase YIL035c CKA1 casein kinase II, catalytic α subunit concentration of Ca2+ YHR030c SLT2 ser/thr protein kinase of MAP kinase YER123w YCK3 casein kinase, isoform 3 YNL189w SRP1 karyopherin-α or importin family YLR178c TFS1 cdc25-dependent nutrient- and ammonia- YEL061c CIN8 kinesin-related protein YJL095w BCK1 ser/thr protein kinase of the MEKK family response cell-cycle regulator YPR141c KAR3 kinesin-related protein YER167w BCK2 ser/thr protein kinase of the protein YGR049w SCM4 cdc4 suppressor YBL063w KIP1 kinesin-related protein kinase C pathway YFL029c CAK1 cdk-activating protein kinase YJR060w CBF1 kinetochore protein YGR092w DBF2 ser/thr protein kinase related to Dbf20p YMR055c BUB2 cell-cycle arrest protein

44 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YKL101w HSL1 ser/thr protein kinase that interacts cytokinesis YPR186c TFC2 TFIIIA subunit (transcription initiation genetically with histone mutations factor) YHR102w NRK1 ser/thr protein kinase that interacts with YDL029w ACT2 actin-like protein YGR246c BRF1 TFIIIB subunit, 70K Cdc31p YPL255w BBP1 cell division control protein YNL039w TFC5 TFIIIB subunit, 90K YNL307c MCK1 ser/thr/tyr protein kinase YCR002c CDC10 cell division control protein YGR047c TFC4 TFIIIC subunit (transcription initiation YDL028c MPS1 ser/thr/tyr protein kinase YLR314c CDC3 cell division control protein factor), 131K YPL153c SPK1 ser/thr/tyr protein kinase YNL327w EGT2 cell-cycle regulation protein YAL001c TFC3 TFIIIC subunit (transcription initiation YJL187c SWE1 ser/tyr dual-specifity protein kinase YNL192w CHS1 chitin synthase I factor), 138K YGL003c similarity to C. elegans CDC20 protein YLR286c CTS1 endochitinase YBR123c TFC1 TFIIIC subunit (transcription initiation and human p55CDC YOR156c NFI1 interacts with Cdc12p in 2-hybrid assay factor), 95K YDL225w similarity to Cdc11p, Cdc3p and human YNL225c involved in cytokinesis YBR049c REB1 transcription factor CDC10 protein YLR131c ACE2 metallothionein expression activator YDL179w similarity to cyclin G1 homologue HCS26 YAL029c MYO4 myosin heavy chain, unconventional rRNA processing YNL001w DOM34 similarity to D. melanogaster pelota (class V) isoform protein YHR023w MYO1 myosin-1 isoform (type II myosin) heavy YOR048c RAT1 5’-3’ exoribonuclease YNL246w similarity to D. melanogaster SET protein chain YBR142w MAK5 ATP-dependent RNA helicase YAR003w FUN16 similarity to human RB protein binding YCR057c PWP2 periodic tryptophan protein YNL112w DBP2 ATP-dependent RNA helicase of DEAD protein YNL267w PIK1 phosphatidylinositol 4-kinase box family YKL179c similarity to Nuf1p YJR076c CDC11 septin YFL002c SPB4 ATP-dependent RNA helicase of DEAH YDL125c YHI1 similarity to protein kinase C inhibitor-I YHR107c CDC12 septin box family YMR262w similarity to S. pombe scn1 protein YGL190c CDC55 ser/thr phosphatase 2A regulatory YPL029w SUV3 ATP-dependent RNA helicase, YLR356w similarity to SCM4 protein subunit B mitochondrial YIL095w PRK1 similarity to ser/thr protein kinase YAL016w TPD3 ser/thr phosphatase 2A, regulatory YJL033w HCA4 can suppress the U14 snoRNA rRNA YLR179c similarity to Tfs1p and Nsp1p subunit A processing function YOL080c similarity to X. laevis XPMC2 protein YNL298w CLA4 ser/thr protein kinase YMR239c RNT1 double-stranded ribonuclease YFR040w SAP155 Sit4p-associated protein YDL225w similarity to Cdc11p, Cdc3p and human YDL014w NOP1 fibrillarin YKR028w SAP190 Sit4p-associated protein CDC10 protein YGL097w SRM1 GDP/GTP exchange factor for YGL229c SAP4 Sit4p-associated protein YMR197c similarity to Nuf1p Gsp1p/Gsp2p YJL098w SAP185 Sit4p-associating protein YMR235c RNA1 GTPase-activating protein YGL086w MAD1 spindle assembly checkpoint protein other cell-growth, cell-division and DNA- YLL011w SOF1 involved in 18S pre-rRNA production YMR198w CIK1 spindle pole body associated protein synthesis activities YGR158c MTR3 involved in mRNA transport YDR356w NUF1 spindle pole body component YGL173c KEM1 multifunctional nuclease YKL042w SPC42 spindle pole body component YLR248w RCK2 Ca2+/calmodulin-dependent ser/thr YGR159c NSR1 nuclear localization sequence binding YNL126w SPC98 spindle pole body component protein kinase protein YOR257w CDC31 spindle pole body component, centrin YOR101w RAS1 GTP-binding protein YPL043w NOP4 nucleolar protein YOL069w NUF2 spindle pole body protein YNL098c RAS2 GTP-binding protein YDR432w NPL3 nucleolar protein YJL030w MAD2 spindle-assembly checkpoint protein YBR138c HDR1 high-dosage reductional segregation YCR018c SRD1 nucleolar protein YJL013c MAD3 spindle-assembly checkpoint protein defective YHR089c GAR1 nucleolar rRNA processing protein YGL106w strong similarity to calmodulins YHL003c LAG1 longevity-assurance protein YLR223c IFH1 pre-rRNA processing machinery control YHR205w SCH9 strong similarity to cAMP-dependent YDL003w MCD1 mitotic chromosome determinant protein protein kinase YGL091c NBP35 nucleotide-binding protein YMR229c RRP5 processing of pre-ribosomal RNA YER066w strong similarity to cell division control YOL110w SHR5 RAS suppressor YNL221c POP1 protein component of ribonuclease P and protein Cdc4p YGL158w RCK1 ser/thr protein kinase ribonuclease MRP YLR117c strong similarity to D. melanogaster YKL189w similarity to mouse MO25 gene YHR065c RRP3 required for maturation of the 35S primary putative cell-cycle control protein crn transcript YIR012w strong similarity to Dbf8p YLL008w DRS1 RNA helicase of the DEAD box family YBR238c strong similarity to general chromatin YPL266w DIM1 rRNA (adenine-N6,N6-)- factor Spt16p Transcription dimethyltransferase YKL049c CSE4 strong similarity to histone H3 YOR201c PET56 rRNA (guanosine-2’-O-)-methyltransferase YGR231c strong similarity to prohibitins rRNA synthesis YPL021w SRD2 similarity to Srd1p YLR215c strong similarity to rat cell cycle YHL034c SBP1 single-strand nucleic acid binding protein progression related D123 protein YJR063w RPA12 DNA-directed RNA polymerase I, 13.7K YLR059c YNT20 suppressor of rna12 yme2 YKL161c strong similarity to ser/thr-specific protein YPR010c RPA135 DNA-directed RNA polymerase I, 135K kinase Slt2p subunit other rRNA-transcription activities YNL172w APC1 subunit of anaphase-promoting complex YOR341w RPA190 DNA-directed RNA polymerase I, 190K (cyclosome) α subunit YNL216w RAP1 DNA-binding protein with repressor and YKL022c CDC16 subunit of anaphase-promoting complex YOR340c RPA43 DNA-directed RNA polymerase I, 36K activator activity (cyclosome) subunit YMR302c PRP12 involved in early maturation of pre-rRNA YHR166c CDC23 subunit of anaphase-promoting complex YNL248c RPA49 DNA-directed RNA polymerase I, 49K (cyclosome) α subunit tRNA synthesis YFR036w CDC26 subunit of anaphase-promoting complex YDR156w RPA14 DNA-directed RNA polymerase I, A14 (cyclosome) subunit YGL019w CKB1 casein kinase II, β subunit YBL084c CDC27 subunit of anaphase-promoting complex YOR224c RPB8 DNA-directed RNA polymerase I, II, III 16K YOR224c RPB8 DNA-directed RNA polymerase I, II, III 16K (cyclosome) subunit subunit YOR213c subunit of the RSC complex YPR187w RPO26 DNA-directed RNA polymerase I, II, III 18K YPR187w RPO26 DNA-directed RNA polymerase I, II, III 18K YCR052w RSC6 subunit of the RSC complex subunit subunit YFR037c RSC8 subunit of the RSC complex YBR154c RPB5 DNA-directed RNA polymerase I, II, III 25K YBR154c RPB5 DNA-directed RNA polymerase I, II, III 25K YLR321c SFH1 subunit of the RSC complex subunit subunit YIL126w STH1 subunit of the RSC complex YHR143w-a RPC10 DNA-directed RNA polymerase I, II, III 7.7K YHR143w-a RPC10 DNA-directed RNA polymerase I, II, III 7.7K YJR091c JSN1 suppresses the high-temperature lethality subunit subunit of tub2-150 YOR210w RPB10 DNA-directed RNA polymerase I, II, III YOR210w RPB10 DNA-directed RNA polymerase I, II, III YIL031w SMT4 suppressor of mif2 temperature-sensitive 8.3K subunit 8.3K subunit mutation YPR110c RPC40 DNA-directed RNA polymerase I, III 40K YPR110c RPC40 DNA-directed RNA polymerase I, III 40K YDR285w ZIP1 synaptonemal complex protein subunit subunit YPL129w ANC1 TFIIF subunit (transcription initiation YNL113w RPC19 DNA-directed RNA polymerase I, III, 16K YNL113w RPC19 DNA-directed RNA polymerase I, III, 16K factor), 30K subunit subunit YPR025c CCL1 TFIIH subunit (transcription initiation YOR207c RPC128 DNA-directed RNA polymerase III, 130K YOR207c RPC128 DNA-directed RNA polymerase III, 130K factor), cyclin C component subunit subunit YLR043c TRX1 thioredoxin I YOR116c RPO31 DNA-directed RNA polymerase III, 160K YOR116c RPO31 DNA-directed RNA polymerase III, 160K YGR209c TRX2 thioredoxin II subunit subunit YOL115w TRF4 topoisomerase I-related protein YKL144c RPC25 DNA-directed RNA polymerase III, 25K YKL144c RPC25 DNA-directed RNA polymerase III, 25K YDL165w CDC36 transcription factor subunit subunit YER111c SWI4 transcription factor YNL151c RPC31 DNA-directed RNA polymerase III, 31K YNL151c RPC31 DNA-directed RNA polymerase III, 31K YLR182w SWI6 transcription factor subunit subunit YGL181w GTS1 transcription factor of the YNR003c RPC34 DNA-directed RNA polymerase III, 34K YNR003c RPC34 DNA-directed RNA polymerase III, 34K Gcs1p/Glo3p/Sps18p family subunit subunit YMR043w MCM1 transcription factor of the MADS box YDL150w RPC53 DNA-directed RNA polymerase III, 47K YDL150w RPC53 DNA-directed RNA polymerase III, 47K family subunit subunit YHR206w SKN7 transcription factor with similarity to Hsf1p YPR190c RPC82 DNA-directed RNA polymerase III, 82K YPR190c RPC82 DNA-directed RNA polymerase III, 82K YDL056w MBP1 transcription factor, subunit of the MBF subunit subunit factor YLR039c RIC1 involved in transcription of ribosomal YER148w SPT15 TFIID and TFIIIB subunit YOR028c CIN5 transcriptional activator proteins and ribosomal RNA YPR186c TFC2 TFIIIA subunit (transcription initiation YNL012w SPO1 transcriptional regulator involved in YKL125w RRN3 RNA polymerase I specific transcription factor) sporulation factor YGR246c BRF1 TFIIIB subunit, 70K YOR361c PRT1 translation initiation factor eIF3 subunit YBL025w RRN10 RNA polymerase I specific transcription YNL039w TFC5 TFIIIB subunit, 90K YHR165c PRP8 U5 snRNP protein, pre-mRNA splicing initiation factor YGR047c TFC4 TFIIIC subunit (transcription initiation factor YML043c RRN11 RNA polymerase I specific transcription factor), 131K YDR054c CDC34 ubiquitin-conjugating enzyme initiation factor YAL001c TFC3 TFIIIC subunit (transcription initiation YDL064w UBC9 ubiquitin-conjugating enzyme YLR141w RRN5 RNA polymerase I specific transcription factor), 138K YMR276w DSK2 ubiquitin-like protein initiation factor YBR123c TFC1 TFIIIC subunit (transcription initiation YML115c VAN1 vanadate resistance protein YBL014c RRN6 RNA polymerase I specific transcription factor), 95K YHR071w weak similarity to cyclin G1 homolog initiation factor HCS26 protein YJL025w RRN7 RNA polymerase I specific transcription tRNA processing YER122c GLO3 zinc-finger protein initiation factor YLR403w SFP1 zinc-finger protein YMR270c RRN9 RNA polymerase I specific transcription YIL075c SEN3 26S proteasome regulatory subunit YGR044c RME1 zinc-finger transcription factor initiation factor YGL097w SRM1 GDP/GTP exchange factor for YER148w SPT15 TFIID and TFIIIB subunit Gsp1p/Gsp2p YMR235c RNA1 GTPase activating protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 45 gazetteer

YHR006w STP2 involved in pre-tRNA splicing YIL021w RPB3 DNA-directed RNA-polymerase II, 45K YOR047c STD1 dosage-dependent modulator of glucose YLR375w STP3 involved in pre-tRNA splicing and in YIL128w MMS19 involved in repair and RNA polymerase repression uptake of branched-chain amino acids transcription YER159c NCB1 functional homologue of human NC2α YDL048c STP4 involved in pre-tRNA splicing and in YMR228w MTF1 RNA polymerase specific factor, YDR397c YNC2β functional homologue of human uptake of branched-chain amino acids mitochondrial NC2β/Dr1 YCL017c NFS1 involved in tRNA processing and YPR056w similarity to human transcription factor YPL037c EGD1 GAL4 DNA-binding enhancer protein mitochondrial metabolsim BTF2/TFIIH subunit p34 YJL110c GZF3 GATA zinc-finger protein 3 YNR034w SOL1 multicopy suppressor of los1-1 YPL046c strong similarity to human DNA-directed YIL038c NOT3 general negative regulator of transcription, YCR073w-a SOL2 multicopy suppressor of los1-1 RNA polymerase II elongation factor SIII, subunit 3 YMR047c NUP116 nuclear pore protein p15 YBR112c CYC8 general repressor of transcription YGL092w NUP145 nuclear pore protein YDR045c strong similarity to S. acidocaldarius YCR084c TUP1 general transcription repressor YJR042w NUP85 nuclear pore protein transcription elongation factor tfs YDR176w NGG1 general transcriptional adaptor or co- YLR430w SEN1 positive effector of tRNA-splicing YKL058w TOA2 TFIIA subunit (transcription initiation activator endonuclease factor), 13.5K YBR045c GIP1 Glc7p-interacting protein YAL043c PTA1 pre-tRNA processing protein YOR194c TOA1 TFIIA subunit (transcription initiation YNL236w SIN4 global regulator protein YKL205w LOS1 pre-tRNA splicing protein factor), 32K YHL025w SNF6 global transcription activator YDR463w STP1 pre-tRNA splicing protein YPR086w SUA7 TFIIB subunit (transcription initiation YER027c GAL83 glucose repression protein YNL221c POP1 protein component of ribonuclease P and factor), factor E YNL199c GCR2 glycolytic genes transcriptional activator ribonuclease MRP YER148w SPT15 TFIID and TFIIIB subunit YGL073w HSF1 heat shock transcription factor YML091c RPM2 ribonuclease P, mitochondrial YGR274c TAF145 TFIID subunit (TBP-associated factor), YPR065w ROX1 heme-dependent transcriptional repressor YFR004w MPR1 strong similarity to S. pombe pad1 protein 145K of hypoxic genes YGR248w SOL4 strong similarity to Sol3p YMR236w TAF17 TFIID subunit (TBP-associated factor), 17K YDR006c SOK1 high copy suppressor of a cyclic AMP- YJL087c TRL1 tRNA ligase YML098w TAF19 TFIID subunit (TBP-associated factor), 19K dependent protein kinase mutant YLR105c SEN2 tRNA splicing endonuclease β subunit YDR167w TAF23 TFIID subunit (TBP-associated factor), 23K YMR070w HMS1 high-copy suppressor of mot1 spt3 YHR163w SOL3 weak multicopy suppressor of los1-1 YML015c TAF40 TFIID subunit (TBP-associated factor), 40K synthetic lethality YGL112c TAF60 TFIID subunit (TBP-associated factor), 60K YGR252w GCN5 histone acetyltransferase tRNA modification YDR145w TAF61 TFIID subunit (TBP-associated factor), 61K YDR225w HTA1 histone H2A YMR227c TAF67 TFIID subunit (TBP-associated factor), 67K YBL003c HTA2 histone H2A.2 YGR204w ADE3 C1-tetrahydrofolate synthase, cytoplasmic YBR198c TAF90 TFIID subunit (TBP-associated factor), 90K YDR224c HTB1 histone H2B YMR283c RIT1 initiator tRNA phosphoribosyl-transferase YKR062w TFA2 TFIIE subunit (transcription initiation YBL002w HTB2 histone H2B.2 YDR120c TRM1 N2,N2-dimethylguanine tRNA factor), 43K YBR010w HHT1 histone H3 methyltransferase YKL028w TFA1 TFIIE subunit (transcription initiation YNL031c HHT2 histone H3 YGL105w G4P1 protein with specific affinity for G4 factor), 66K YBR009c HHF1 histone H4 quadruplex nucleic acids YGR186w TFG1 TFIIF subunit (transcription initiation YNL030w HHF2 histone H4 YPL212c PUS1 pseudouridine synthase 1 factor), 105K YBL008w HIR1 histone transcription regulator YGL063w PUS2 pseudouridine synthase 2 YPL129w ANC1 TFIIF subunit (transcription initiation YOR038c HIR2 histone transcription regulator YFR010w similarity to C. elegans tRNA-guanine factor), 30K YER161c SPT2 HMG-like chromatin protein transglycosylase YGR005c TFG2 TFIIF subunit (transcription initiation YDL106c GRF10 homeodomain protein YBL013w similarity to methionyl-tRNA factor), 54K YDR138w HPR1 hyperrecombination protein related to formyltransferase YDR311w TFB1 TFIIH subunit (transcription initiation Top1p YOR274w MOD5 tRNA isopentenyltransferase factor), 75K YJL089w SIP4 interacts with SNF1 protein kinase YER168c CCA1 tRNA nucleotidyltransferase YPR025c CCL1 TFIIH subunit (transcription initiation YKL032c IXR1 intrastrand crosslink recognition protein factor), cyclin C component and transcription factor other tRNA-transcription activities YLR005w SSL1 TFIIH subunit (transcription initiation YBR081c SPT7 involved in alteration of transcription start factor), factor B site selection YOR061w CKA2 casein kinase II α‘ subunit YPL122c TFB2 TFIIH subunit (transcription/repair factor) YKR072c SIS2 involved in cell cycle-specific gene YOR039w CKB2 casein kinase II β‘ subunit YDR460w TFB3 TFIIH subunit (transcription/repair factor) expression YJL041w NSP1 nuclear pore protein YGL043w DST1 TFIIS (transcription elongation factor) YNL251c NRD1 involved in regulation of nuclear pre- YGR063c SPT4 transcription initiation protein mRNA abundance mRNA synthesis YML010w SPT5 transcription initiation protein YIL046w MET30 involved in regulation of sulphur YGR116w SPT6 transcription initiation protein assimilation genes general transcription activities YDL153c SAS10 involved in silencing YDL108w KIN28 cyclin-dependent ser/thr protein kinase transcriptional control YMR127c SAS2 involved in silencing at HMR YIL143c SSL2 DNA helicase YOR259c CRL13 26S proteasome subunit YGR097w ASK10 involved in Skn7p-dependent transcription YER171w RAD3 DNA helicase/ATPase YJL115w ASF1 anti-silencing protein YLR039c RIC1 involved in transcription of ribosomal YOR224c RPB8 DNA-directed RNA polymerase I, II, III 16K YDL197c ASF2 anti-silencing protein proteins and ribosomal RNA subunit YDR173c ARG82 arginine metabolism transcription factor YGL071w RCS1 iron-regulated transcriptional repressor YPR187w RPO26 DNA-directed RNA polymerase I, II, III 18K YKL112w ABF1 ARS-binding factor YJR060w CBF1 kinetochore protein subunit YDR123c INO2 basic helix-loop-helix (BHLH) transcription YDR159w SAC3 leucine permease transcriptional regulator YBR154c RPB5 DNA-directed RNA polymerase I, II, III 25K factor YGR100w MIC1 Mac1p interacting protein subunit YOL108c INO4 basic helix-loop-helix transcription factor YBR297w MAL33 maltose fermentation regulatory protein YHR143w-a RPC10 DNA-directed RNA polymerase I, II, III 7.7K YOL067c RTG1 basic helix-loop-helix transcription factor YGR288w MAL13 maltose pathway regulatory protein subunit YOR344c TYE7 basic helix-loop-helix transcription factor YCR040w MATα1 mating type regulatory protein (expressed YOR210w RPB10 DNA-directed RNA polymerase I, II, III YBL103c RTG3 bHLH/zip transcription factor copy at MAT locus) 8.3K subunit YHL009c bZip DNA binding protein YCR039c MATα2 mating type regulatory protein (expressed YOL051w GAL11 DNA-directed RNA polymerase II YGL209w MIG2 C2H2 zinc-finger protein copy at MAT locus) holoenzyme and Kornberg’s mediator YKL190w CNB1 calcineurin B, regulatory subunit YCL067c α2 mating type regulatory protein (silenced (SRB) subcomplex subunit YML112w CTK3 carboxy terminal domain (CTD) kinase, copy at HML locus) YDR443c SCA1 DNA-directed RNA polymerase II γ subunit YHL027w RIM101 meiotic regulatory protein holoenzyme and Kornberg’s mediator YJL006c CTK2 carboxy-terminal domain (CTD) kinase , YLR216c CPR6 member of the cyclophilin family (SRB) subcomplex subunit β subunit YJR032w CPR7 member of the cyclophilin family YHR041c SRB2 DNA-directed RNA polymerase II YKL139w CTK1 carboxy-terminal domain (CTD) kinase, YLR136c TIS11 member of the inducible ccch zinc-finger holoenzyme and Kornberg’s mediator α subunit family (SRB) subcomplex subunit YIL035c CKA1 casein kinase II, catalytic α subunit YOL148c SPT20 member of the TBP class of SPT proteins YER022w SRB4 DNA-directed RNA polymerase II YGL237c HAP2 CCAAT-binding factor subunit that alter transcription site selection holoenzyme and Kornberg’s mediator YBL021c HAP3 CCAAT-binding factor subunit YMR021c MAC1 metal binding activator (SRB) subcomplex subunit YKL109w HAP4 CCAAT-binding factor subunit YLR131c ACE2 metallothionein expression activator YGR104c SRB5 DNA-directed RNA polymerase II YOR358w HAP5 CCAAT-binding factor subunit YBR026c (MRF1) mitochondrial respiratory function protein holoenzyme and Kornberg’s mediator YJR122w CAF17 CCR4-associated factor YML051w GAL80 negative regulator for expression of (SRB) subcomplex subunit YKR036c CAF4 CCR4-associated factor galactose-induced genes YDR308c SRB7 DNA-directed RNA polymerase II YBR215w HPC2 cell-cycle regulatory protein YGL151w NUT1 negative regulator of HO endonuclease holoenzyme and Kornberg’s mediator YDL220c CDC13 cell division control protein YPR168w NUT2 negative regulator of HO endonuclease (SRB) subcomplex subunit YDR073w SNF11 component of SWI/SNF transcription YKL185w ASH1 negative regulator of HO expression YCR081w SRB8 DNA-directed RNA polymerase II activator complex YHL020c OPI1 negative regulator of phospholipid holoenzyme and Kornberg’s mediator YNR023w SNF12 component of SWI/SNF transcription biosynthesis pathway (SRB) subcomplex subunit activator complex YDR464w SPP41 negative regulator of PRP3 and PRP4 YNL025c SSN8 DNA-directed RNA polymerase II YOR290c SNF2 component of SWI/SNF transcription gene expression holoenzyme and Kornberg’s mediator activator complex YNL076w MKS1 negative regulator of RAS-cAMP pathway (SRB) subcomplex subunit, cyclin C YBR289w SNF5 component of SWI/SNF transcription YDR207c UME6 negative transcriptional regulator homologue activator complex YGL221c NIF3 Ngg1p-interacting factor 3 YLR071c RGR1 DNA-directed RNA polymerase II YPL016w SWI1 component of SWI/SNF transcription YGL115w SNF4 nuclear regulatory protein holoenzyme subunit activator complex YCR093w CDC39 nuclear transmembrane protein YBR253w SRB6 DNA-directed RNA polymerase II YCR042c TSM1 component of TAF(II) complex YML065w ORC1 origin recognition complex, 104K subunit suppressor protein YPL177c CUP9 copper homeostasis protein YNL261w ORC5 origin recognition complex, 50K subunit YOL005c RPB11 DNA-directed RNA polymerase II, 13.6K YGL166w CUP2 copper-dependent transcription factor YHR118c ORC6 origin recognition complex, 50K subunit subunit YNL167c SKO1 cre-binding bzip protein YPR162c ORC4 origin recognition complex, 56K subunit YGL070c RPB9 DNA-directed RNA polymerase II, 14.2K YPL042c SSN3 cyclin-dependent ser/thr protein kinase YLL004w ORC3 origin recognition complex, 62K subunit subunit YLR176c RFX1 DNA binding protein YBR060c RRR1 origin recognition complex, 72K subunit YOR151c RPB2 DNA-directed RNA polymerase II, 140K YDR217c RAD9 DNA repair checkpoint protein YAL051w OAF1 peroxisome proliferating transcription subunit YNL216w RAP1 DNA-binding protein with repressor and factor YDR404c RPB7 DNA-directed RNA polymerase II, 19K activator activity YOR363c PIP2 peroxisome proliferating transcription subunit YLR418c CDC73 DNA-directed RNA polymerase II factor YDL140c RPO21 DNA-directed RNA polymerase II, 215K accessory protein YBL005w PDR3 pleiotropic drug resistance regulatory subunit YBR279w PAF1 DNA-directed RNA polymerase II protein YJL140w RPB4 DNA-directed RNA polymerase II, 32K regulator YKL015w PUT3 positive activator of the proline utilization subunit YGL208w SIP2 dominant suppressor of some ts pathway YFL036w RPO41 DNA-directed RNA polymerase, mutations rpo21 and prp4 YGL192w IME4 positive transcription factor for IME2 mitochondrial

46 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YDR017c KCS1 potential transcription factor of the BZIP YFR037c RSC8 subunit of the RSC complex chromatin modification type YLR321c SFH1 subunit of the RSC complex YBR195c MSI1 chromatin assembly complex, subunit YGL025c PGD1 probable transcription factor YIL126w STH1 subunit of the RSC complex p50 YER108c FLO8 probable transcriptional activator of Flo1p YGL254w FZF1 sulphite resistance protein YML102w CAC2 chromatin assembly complex, subunit YGL194c RTL1 putative deacetylase YNL222w SSU72 suppressor of cs mutant sua7 p60 YJL103c putative regulatory protein YDR310c SUM1 suppressor of mar1-1 YPR018w RLF2 chromatin assembly complex, subunit YBL066c SEF1 putative transcription factor YKR099w BAS1 transcription factor p90 YHR056c putative transcription regulator YDL165w CDC36 transcription factor YGL207w SPT16 general chromatin factor YBR275c RIF1 Rap1p-interacting factor 1 YLR098c CHA4 transcription factor YGR252w GCN5 histone acetyltransferase YKL038w RGT1 regulator of glucose induced genes YPL248c GAL4 transcription factor YGL194c RTL1 putative deacetylase YDR257c RMS1 regulatory protein YFL031w HAC1 transcription factor YHR119w YTX1 regulatory protein YDR392w SPT3 regulatory protein YLR256w HAP1 transcription factor YBR238c strong similarity to general chromatin YMR016c SOK2 regulatory protein in the PKA signal YCR065w HCM1 transcription factor factor Spt16p transduction pathway YLR451w LEU3 transcription factor YFR004w MPR1 strong similarity to S. pombe pad1 protein YCL055w KAR4 regulatory protein required for pheromone YGL013c PDR1 transcription factor YOR213c subunit of the RSC complex induction of karyogamy genes YKL043w PHD1 transcription factor YCR052w RSC6 subunit of the RSC complex YNR052c POP2 required for glucose derepression YFR034c PHO4 transcription factor YFR037c RSC8 subunit of the RSC complex YMR179w SPT21 required for normal transcription at a YBR049c REB1 transcription factor YLR321c SFH1 subunit of the RSC complex number of loci YBL093c ROX3 transcription factor YIL126w STH1 subunit of the RSC complex YKL093w MBR1 required for optimal growth on glycerol YOR140w SFL1 transcription factor YGR274c TAF145 TFIID subunit (TBP-associated factor), YOL068c HST1 silencing protein YLR055c SPT8 transcription factor 145K YOR025w HST3 silencing protein YER111c SWI4 transcription factor YGR063c SPT4 transcription initiation protein YBL052c SAS3 silencing protein YDR146c SWI5 transcription factor YML010w SPT5 transcription initiation protein YKR101w SIR1 silencing regulatory protein YLR182w SWI6 transcription factor YGR116w SPT6 transcription initiation protein YDL042c SIR2 silencing regulatory protein YFL021w GAT1 transcription factor for nitrogen regulation YLR442c SIR3 silencing regulatory protein YER040w GLN3 transcription factor for positive nitrogen mRNA processing (splicing) YDR227w SIR4 silencing regulatory protein regulation YKL070w similarity to B. subtilis transcriptional YMR042w ARG80 transcription factor involved in arginine YBL074c AAR2 A1 cistron splicing factor regulatory protein metabolism YHL038c CBP2 apo-cytochrome b pre-mRNA processing YDL070w similarity to bromodomain protein BDF1 YML099c ARG81 transcription factor involved in arginine protein 2 YIL131c FKH1 similarity to D. melanogaster fork head metabolism YPL119c DBP1 ATP-dependent RNA helicase protein YMR280c CAT8 transcription factor involved in YOR204w DED1 ATP-dependent RNA helicase YJL056c similarity to developmental control gluconeogenesis YBR142w MAK5 ATP-dependent RNA helicase proteins YGL181w GTS1 transcription factor of the YPL029w SUV3 ATP-dependent RNA helicase, YBR061c similarity to E. coli ftsJ protein Gcs1p/Glo3p/Sps18p family mitochondrial YJR147w similarity to heat-shock transcription YMR043w MCM1 transcription factor of the MADS box YNL286w CUS2 cold sensitive U2 snRNA suppressor factors family YIR021w MRS1 involved in mitochondrial RNA splicing of YGR249w MGA1 similarity to heat-shock transcription YPL089c RLM1 transcription factor of the MADS box COB mRNA factors family YOR148c SPP2 involved in pre-mRNA processing YPL015c HST2 similarity to Hst1p and Sir2p YLR014c PPR1 transcription factor regulating pyrimidine YPR057w BRR1 involved in snRNP biogenesis YDR191w HST4 similarity to Hst3p,Hst1p and Sir2p pathway YLR382c NAM2 leucine-tRNA ligase, mitochondrial YNL107w similarity to human AF-9 protein YJR094c IME1 transcription factor required for YNL210w MER1 meiotic recombination protein YHR193c EGD2 similarity to human α-NAC sporulation YHR086w NAM8 meiotic recombination protein YAR003w FUN16 similarity to human RB protein binding YHR206w SKN7 transcription factor with similarity to Hsf1p YMR023c MSS1 mitochondrial GTPase involved in protein YDL056w MBP1 transcription factor, subunit of the MBF expression of COX1 YER169w similarity to human retinoblastoma factor YLL036c PRP19 non-snRNP sliceosome component binding protein 2 YNL330c RPD3 transcription modifier protein required for DNA repair YJR119c similarity to human retinoblastoma YOL004w SIN3 transcription regulatory protein YBR237w PRP5 pre-mRNA processing RNA-helicase binding protein 2 YJL127c SPT10 transcription regulatory protein YKL074c MUD2 pre-mRNA splicing factor YLR116w similarity to human ZFM1 protein and YJL176c SWI3 transcription regulatory protein YDL043c PRP11 pre-mRNA splicing factor mouse CW17R protein YPL082c MOT1 transcriptional accessory protein YJL203w PRP21 pre-mRNA splicing factor YJL206c similarity to hypothetical protein YIL130p YDR423c CAD1 transcriptional activator YER013w PRP22 pre-mRNA splicing factor and Put3p YOR028c CIN5 transcriptional activator YMR268c PRP24 pre-mRNA splicing factor YOL133w similarity to Lotus RING-finger protein YPL075w GCR1 transcriptional activator YGR075c PRP38 pre-mRNA splicing factor YER130c similarity to Msn2p and Msn4p YOL116w MSN1 transcriptional activator YML046w PRP39 pre-mRNA splicing factor YER184c similarity to multidrug resistance protein YKL062w MSN4 transcriptional activator YDL030w PRP9 pre-mRNA splicing factor (snRNA- PDR3 YHR084w STE12 transcriptional activator associated protein) YIL050w similarity to N. crassa regulatory protein YIR023w DAL81 transcriptional activator for allantoin and YDR088c SLU7 pre-mRNA splicing factor affecting 3’ preg(+) GABA catabolic genes splice site choice YLR013w similarity to nitrogen regulatory proteins YNL314w DAL82 transcriptional activator for allantoin YDR243c PRP28 pre-mRNA splicing factor RNA helicase of YDR334w similarity to nuclear Sth1p, Snf2p and catabolic genes DEAD box family related proteins YDL170w UGA3 transcriptional activator for GABA YGR091w PRP31 pre-mRNA splicing protein YPR115w similarity to probable transcription factor catabolic genes YDL044c MTF2 protein involved in mRNA splicing and Ask10p, and to hypothetical proteins YML007w YAP1 transcriptional activator involved in protein synthesis, mitochondrial YNL047c and YIL105c oxidative stress response YBR091c MRS5 regulator of intron splicing, mitochondrial YIL130w similarity to Put3p and to hypothetical YEL009c GCN4 transcriptional activator of amino acid YDR028c REG1 regulatory subunit for protein protein YJL206c biosynthetic genes phosphatase Glc7p YCR020c PET18 similarity to regulatory protein YDR034c LYS14 transcriptional activator of lysine pathway YDR478w SNM1 RNA binding protein of RNase MRP YBR182c similarity to Rlm1p,Mcm1p, and hMEF2 genes YDR194c MSS116 RNA helicase of the DEAD box family, YKR008w similarity to S. pombe bromodomain YIR017c MET28 transcriptional activator of sulphur amino mitochondrial protein acid metabolism YER172c BRR2 RNA helicase-related protein YGL150c similarity to Snf2p and human SNF2α YNL103w MET4 transcriptional activator of sulphur YOR334w MRS2 RNA splicing protein and member of the YLR228c similarity to transcription activator Lys14p metabolism mitochondrial carrier family (MCF) YLL054c similarity to transcription factor Pip2p YPR104c FHL1 transcriptional activator of the YJL133w MRS3 RNA splicing protein and member of the YLR266c similarity to transcription factors forkhead/hnf3 family mitochondrial carrier family (MCF) YLR278c similarity to transcription factors YDR448w ADA2 transcriptional adaptor YKR052c MRS4 RNA splicing protein and member of the YDR303c similarity to transcriptional regulator YMR039c SUB1 transcriptional coactivator mitochondrial carrier family (MCF) proteins YAL021c CCR4 transcriptional regulator YKR086w PRP16 RNA-dependent ATPase YMR019w STB4 SIN3 binding protein YER164w CHD1 transcriptional regulator YNR011c PRP2 RNA-dependent ATPase of DEAH box YHR178w STB5 SIN3 binding protein YIL084c SDS3 transcriptional regulator family YKL072w STB6 SIN3 binding protein YNL012w SPO1 transcriptional regulator involved in YHR004c-a similarity to mitochondrial splicing protein YNL309w STB1 Sin3p binding protein sporulation Mrs5p YMR053c STB2 Sin3p binding protein YGL035c MIG1 transcriptional repressor YKR024c similarity to pre-mRNA processing protein YLR399c BDF1 sporulation protein YER068w MOT2 transcriptional repressor Prp5p YNL204c SPS18 sporulation-specific zinc-finger protein YKR034w DAL80 transcriptional repressor for allantoin and YGR074w SMD1 snRNA-associated protein YMR037c stress responsive regulatory protein GABA catabolic genes YPR182w SMX3 snRNA-associated protein of the SM YDR026c strong similarity to DNA-binding protein YMR182c RGM1 transcriptional repressor protein family Reb1p YCL054w transcriptional silencing protein YBR055c PRP6 snRNP(U4/U6)-associated splicing factor YDR252w BTT1 strong similarity to Egd1p and to human YBR083w TEC1 Ty transcription activator YKL012w PRP40 splicing factor Btf3 protein YOR337w TEA1 TY1 enhancer activator YPR134w MSS18 splicing protein YHR211w FLO5 strong similarity to Flo1p YER151c UBP3 ubiquitin-specific proteinase YGR222w PET54 splicing protein and translational activator, YOR304w strong similarity to human Snf2p YER088c weak similarity human transforming mitochondrial homologue proteins (B-myb) YKL078w strong similarity to ATP-dependent RNA YOL055c strong similarity to hypothetical proteins YBR240c weak similarity to regulatory proteins helicases YPL258c, YPR121w, similarity to B. subtilis YML076c weak similarity to transcription factor YOR159c SME1 strong similarity to human small nuclear transcriptional activator tenA YCR106w weak similarity to transcription factor ribonucleoprotein E YFL052w strong similarity to Mal63p, Mal23p and Pip2p YLR275w strong similarity to human snRNP subunit Mal33p YBR033w weak similarity to transcription factors D2 involved in systemic lupus YPR196w strong similarity to regulatory protein YKR064w weak similarity to transcription factors erythematosus Mal63p YOL089c weak similarity to transcription factors YPL060w strong similarity to Mrs2p YBR245c strong similarity to SNF2/SWI2 DNA YKL222c weak similarity to transcription factors, YGL120c strong similarity to Prp22p binding regulatory protein similarity to finger proteins YOR162c, YLR147c SMD3 strong similarity to small nuclear YDR253c strong similarity to zinc-finger proteins YOR172w and YLR266c ribonucleoprotein D3 YML081w strong similarity to ZMS1 protein YBL054w weak similarity transforming protein (B- YIR009w MSL1 strong similarity to small nuclear YEL056w HAT2 subunit of the major yeast histone myb) ribonucleoproteins acetyltransferase YER122c GLO3 zinc-finger protein YIL061c SNP1 U1 small nuclear ribonucleoprotein YOR213c subunit of the RSC complex YDR216w ADR1 zinc-finger transcription factor YBR119w MUD1 U1 snRNP-specific A protein YCR052w RSC6 subunit of the RSC complex YGR044c RME1 zinc-finger transcription factor YMR240c CUS1 U2 snRNP protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 47 gazetteer

YPR178w PRP4 U4/U6 snRNP 52K protein YER110c KAP123 RAN-binding protein YOR096w RP30 ribosomal protein YGR006w PRP18 U5 snRNA-associated protein YDR002w YRB1 ran-specific GTPase-activating protein YKL006w RPL14A ribosomal protein YHR165c PRP8 U5 snRNP protein, pre-mRNA splicing YER107c GLE2 required for nuclear pore complex YHL001w RPL14B ribosomal protein factor structure and function YMR242c RPL18A ribosomal protein YER112w USS1 U6 snRNA associated protein YIR011c STS1 required for transport of Rna15p from the YOR312c RPL18B ribosomal protein cytoplasm to the nucleus YDR471w RPL27B ribosomal protein mRNA processing (5’-end, 3’-end processing YDL207w GLE1 RNA export mediator YLR344w RPL33A ribosomal protein and mRNA degradation) YLR119w SRN2 suppressor of rna1-1 mutation YMR194w RPL39A ribosomal protein YDL184c RPL47A ribosomal protein YJL209w CBP1 apo-cytochrome b pre-mRNA processing other transcription activities YDL133c-a RPL47B ribosomal protein protein YPL198w RPL6B ribosomal protein YBR120c CBP6 apo-cytochrome b pre-mRNA processing YGL127c SOH1 allows hpr1 null mutant to grow at 37ºC YOL040c RPS21 ribosomal protein protein YOR113w AZF1 asparagine-rich zinc-finger protein YLR287c-a RPS30A ribosomal protein YPL178w SAE1 cell cycle block in meiotic prophase YPR198w SGE1 drug resistance protein YDL191w SOS1 ribosomal protein YGL094c PAN2 component of Pab1p-stimulated poly(A) YBR212w NGR1 glucose-repressible RNA-binding protein YDL136w SOS2 ribosomal protein ribonuclease YML027w YOX1 homoeodomain protein YPL220w SSM1A ribosomal protein YMR061w RNA14 component of pre-mRNA 3’-end YNL068c FKH2 homology to D. melanogaster forkhead YGL135w SSM1B ribosomal protein processing factor protein YGL123w SUP44 ribosomal protein YGL044c RNA15 component of pre-mRNA 3’-end YIL030c SSM4 involved in mRNA turnover YIL148w UBI1 ribosomal protein processing factor YNL282w (POP2) involved in processsing RNAs YKR094c UBI2 ribosomal protein YJR093c FIP1 component of pre-mRNA polyadenylation YCR087c-a nucleic acid-binding protein YHL015w URP2 ribosomal protein factor YDL051w YLA1 RNA binding protein YML073c YL16A ribosomal protein YKL025c PAN3 component of the Pab1p-dependent poly YMR164c similarity to CYC8 protein YLR448w YL16B ribosomal protein (A) YGL014w similarity to D. melanogaster pumilio YDR500c RPL35B ribosomal protein L.37.e YOL149w DCP1 component of the yeast decapping protein and HTR1 protein YPR102c RPL16A ribosomal protein L11.e enzyme YIR001c similarity to D. melanogaster RNA binding YDR418w RPL15A ribosomal protein L12.e YGL097w SRM1 GDP/GTP exchange factor for protein YEL054c RPL15B ribosomal protein L12.e Gsp1p/Gsp2p YNL004w HRB1 similarity to Gbp2p YDL082w ribosomal protein L13 YGR158c MTR3 involved in mRNA transport YBR233w similarity to human hnRNP-E1 protein YKL170w MRPL38 ribosomal protein L14, mitochondrial YBR236c ABD1 methyltransferase YPR031w similarity to human zinc-finger protein YLR029c RPL13A ribosomal protein L15.e.c12 YGL130w CEG1 mRNA guanylyltransferase (mRNA BR140 YMR121c RPL13B ribosomal protein L15.e.c13 capping enzyme, α subunit) YCL033c similarity to M. capricolum transcription YJL063c MRPL8 ribosomal protein L17, mitochondrial YER165w PAB1 mRNA polyadenylate-binding protein repressor YKL180w RPL20A ribosomal protein L17.e YLR277c BRR5 mRNA processing protein YIR005w similarity to RNA-binding proteins YJL177w RPL20B ribosomal protein L17.e YKR002w PAP1 poly(A) polymerase YMR213w similarity to S. pombe putative YNL301c RP28B ribosomal protein L18.e YGL122c NAB2 poly(A)-binding protein transcription factor cdc5 YBL027w RPL19A ribosomal protein L19.e YPL190c NAB3 polyadenylated RNA-binding protein YNL175c similarity to S. pombe Rnp24p YBR084c-a RPL19B ribosomal protein L19.e YDR301w CFT1 pre-mRNA 3’-end processing factor YOR244w similarity to SAS2 and SAS3 protein YPL079w URP1B ribosomal protein L21 YJR017c ESS1 processing/termination factor 1 YPR008w similarity to transcription factor YBR191w URP1A ribosomal protein L21.e YDR195w REF2 RNA 3’-end formation protein YPL230w similarity to transcription factors YBL087c RPL17A ribosomal protein L23.e YOR179c similarity to BRR5 protein YPR013c similarity to transcription factors YER117w RPL17B ribosomal protein L23.e YOR319w HSH49 similarity to human SAP49 and RNA- YPR015c similarity to transcription factors YOL127w RPL25 ribosomal protein L23a.e binding proteins YNL027w similarity to zinc-finger proteins YGL031c RPL30A ribosomal protein L24.e.A YHR015w similarity to PES4 PAB-like protein YPL038w similarity to zinc-finger proteins YGR148c RPL30B ribosomal protein L24.e.B YOR159c SME1 strong similarity to human small nuclear YDR169c STB3 SIN3 protein-binding protein YGR034w RPL33B ribosomal protein L26 ribonucleoprotein E YPR107c strong similarity to D. melanogaster zinc- YHR010w RPL27A ribosomal protein L27.e finger protein YGL103w CYH2 ribosomal protein L27a.e other mRNA-transcription activities YIL105c strong similarity to hypothetical protein YBR031w RPL2A ribosomal protein L2A YNL047c, similarity to hypothetical protein YOR063w TCM1 ribosomal protein L3.e YGL171w ROK1 ATP-dependent RNA helicase YPR115w and to probable transcription YGL030w RPL32 ribosomal protein L30.e YOL006c TOP1 DNA topoisomerase I factor Ask10p YDL075w RPL43A ribosomal protein L31.e YGL251c HFM1 DNA/RNA helicase YNL255c strong similarity to nucleic acid-binding YLR406c RPL34B ribosomal protein L31.e.c12 YNL037c IDH1 isocitrate dehydrogenase (NAD+) subunit proteins YBL092w ribosomal protein L32.e 1, mitochondrial YHR169w strong similarity to RNA helicase YIL052c ribosomal protein L34.e YOR136w IDH2 isocitrate dehydrogenase (NAD+) subunit YGL078c strong similarity to RNA helicase DBP2 YOR234c RPL37B ribosomal protein L35a.e.c15 2, mitochondrial protein YPL143w RPL37A ribosomal protein L35a.e.c16 YNL016w PUB1 major polyadenylated RNA-binding protein YCR004c YCP4 strong similarity to S. pombe protein obr1 YNL162w RPL41A ribosomal protein L36a.e of nucleus and cytoplasm YFL017w-a SNP2 strong similarity to snRNP E YHR141c RPL41B ribosomal protein L36a.e YHR170w NMD3 nonsense-mediated mRNA decay protein YDR451c strong similarity to Yox1p YLR185w RPL35A ribosomal protein L37.e YMR064w AEP1 nuclear control of ATPase messenger YML017w PSP2 suppressor of DNA polymerase α YPR043w ribosomal protein L37a.e RNA expression protein mutation YJL189w RPL46 ribosomal protein L39.e YOL123w HRP1 polyadenylated RNA-binding protein YKR092c SRP40 suppressor of mutant AC40 of RNA YDR012w RPL2B ribosomal protein L4.e.B YLR067c PET309 required for stability and translation of polymerase I and III YPL131w RPL1 ribosomal protein L5.e COX1 mRNA YKL005c weak similarity to D. melanogaster YNL002c RLP7 ribosomal protein L7.e YAL016w TPD3 ser/thr phosphatase 2A, regulatory transcription elongation factor DmS-II YGL076c RPL6A ribosomal protein L7.e.A subunit A YNR063w weak similarity to CYC1/CYP3 YHL033c RPL4A ribosomal protein L7a.e.A YOL042w similarity to CCR4 protein transcription activator YLL045c RPL4B ribosomal protein L7a.e.B YER146w similarity to human snRNP E YJL124c weak similarity to human Sm protein G YIL018w RPL5A ribosomal protein L8.e YER029c similarity to human snRNP-associated YDR043c weak similarity to K. marxianus Mig1 and YFR031c-a RPL5B ribosomal protein L8.e protein B other regulatory proteins YGL147c RPL9A ribosomal protein L9.e YER028c similarity to Mig1p YIR018w weak similarity to transcription activator YNL067w RPL9B ribosomal protein L9.e.c14 YDR429c similarity to nuclear RNA binding proteins Pdr4p YGR076c MRPL25 ribosomal protein m (YML25), YJR127c ZMS1 similarity to regulatory protein ADR1 YPR199c weak similarity to transcription activator mitochondrial YDL031w similarity to RNA helicases Yap1p YJR094w-a ribosomal protein of the large subunit YNL147w similarity to snRNP proteins YBR239c weak similarity to transcription factor YOR293w ribosomal protein S10.e YNL021w similarity to transcription factor Rpd3p Put3p YDR025w RPS18A ribosomal protein S11.e YPR068c similarity to transcription factor Rpd3p YBR150c weak similarity to transcription factors YBR048w RPS18B ribosomal protein S11.e.B YPL213w similarity to U2 snRNP protein A’ YGR067c weak similarity to transcription factors YPR166c MRP2 ribosomal protein S14 YBL026w SNP3 snRNP-related protein YPL133c weak similarity to transcription factors YJL191w CRY2 ribosomal protein S14.e.B YDL160c DHH1 strong similarity to RNA helicases of the YER116c zinc-finger protein YJL190c RPS24A ribosomal protein S15a.e.c10 DEAD box family YLR367w RPS24B ribosomal protein S15a.e.c12 YLR147c SMD3 strong similarity to small nuclear YPL013c ribosomal protein S16, mitochondrial ribonucleoprotein D3 YMR143w RPS16A ribosomal protein S16.e YLR139c SLS1 suppresses lethality of SSM4 deletion Protein synthesis YDL083c RPS16B ribosomal protein S16.e YML024w RP51A ribosomal protein S17.e.A RNA transport ribosomal proteins YDR447c RP51B ribosomal protein S17.e.B YOL120c RP28A ribosomal protein S18.e YGL097w SRM1 GDP/GTP exchange factor for YGR214w NAB1A 40S ribosomal protein p40 homologue A YML026c RPS18EB ribosomal protein S18.e.c13 Gsp1p/Gsp2p YLR048w NAB1B 40S ribosomal protein p40 homologue B YDR450w RPS18EA ribosomal protein S18.e.c4 YMR235c RNA1 GTPase activating protein YCR031c CRY1 40S ribosomal protein S14.e YOL121c RP55A ribosomal protein S19.e YOR185c GSP2 GTP-binding protein YGL189c RPS26A 40S ribosomal protein S26e.c7 YNL302c RP55B ribosomal protein S19.e YLR293c GSP1 GTP-binding protein of the ras YML009c MRPL39A 60S ribosomal protein, mitochondrial YKR057w RPS25A ribosomal protein S21.e superfamily YDL081c RPLA1 acidic ribosomal protein a1 YJL136c RPS25B ribosomal protein S21.e YOR160w MTR10 involved in mRNA transport YLR340w RPLA0 acidic ribosomal protein L10.e YGR118w RPS28A ribosomal protein S23.e YGR158c MTR3 involved in mRNA transport YDL130w RPLA3 acidic ribosomal protein L44prime YPR132w RPS28B ribosomal protein S23.e YJL050w MTR4 involved in nucleocytoplasmic transport of YDR382w RPLA4 acidic ribosomal protein L45 YER074w RP50A ribosomal protein S24.e mRNA YOL039w RPLA2 acidic ribosomal protein P2.β YIL069c RP50B ribosomal protein S24.e YKL186c MTR2 mRNA transport protein YOR369c RS12 acidic ribosomal protein S12 YLR333c RPS31B ribosomal protein S25.e.c12 YKL068w NUP100 nuclear pore protein YGL068w probable ribosomal protein L12 YGR027c RPS31A ribosomal protein S25.e.c7 YKL057c NUP120 nuclear pore protein YLR325c putative ribosomal protein L38 YER131w RPS26B ribosomal protein S26e-c5 YKR082w NUP133 nuclear pore protein YFL034c-a ribosomal protein YKL156w RPS27A ribosomal protein S27.e YGL092w NUP145 nuclear pore protein YFR032c-a ribosomal protein YHR021c RPS27B ribosomal protein S27.e YDR192c NUP42 nuclear pore protein YLR061w ribosomal protein YDR064w YS15 ribosomal protein S27A YGL172w NUP49 nuclear pore protein YMR142c ribosomal protein YLR264w RPS33B ribosomal protein S28.e.c12 YJL061w NUP82 nuclear pore protein YPL183w-a ribosomal protein YOR167c RPS33A ribosomal protein S28.e.c15 YDR432w NPL3 nucleolar protein YLR075w GRC5 ribosomal protein YLR388w YS29A ribosomal protein S29.e.A YGL122c NAB2 poly(A)-binding protein YIL133c RP22 ribosomal protein YDL061c YS29B ribosomal protein S29.e.B YKL205w LOS1 pre-tRNA splicing protein YNL069c RP23 ribosomal protein YNL178w RPS3 ribosomal protein S3.e

48 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YLR441c RP10A ribosomal protein S3a.e YLR289w GUF1 strong similarity to E. coli elongation tRNA synthetases YML063w RP10B ribosomal protein S3a.e factor-type GTP-binding protein lepa YJR145c RPS7B ribosomal protein S4.e.c10 YDL084w strong similarity to nuclear RNA helicase YOR335c ALA1 alanyl-tRNA synthetase, cytosolic YHR203c RPS7A ribosomal protein S4.e.c8 (DEAD family) YHR091c MSR1 arginyl-tRNA synthetase, mitochondrial YBR251w MRPS5 ribosomal protein S5, mitochondrial YDR021w strong similarity to translation initiation YCR024c asn-tRNA synthetase, mitochondrial YJR123w RPS5 ribosomal protein S5.e factor eIF4A YHR019c DED81 asparaginyl-tRNA-synthetase YBR181c RPS101 ribosomal protein S6.e YKL010c SOS1 suppressor of sis1 YPL104w MSD1 aspartate-tRNA ligase, mitochondrial YPL090c RPS10B ribosomal protein S6.e YLR005w SSL1 TFIIH subunit (transcription initiation YLL018c DPS1 aspartyl-tRNA synthetase, cytosolic YBL072c RPS8A ribosomal protein S8.e factor), factor B YOR168w GLN4 glutaminyl-tRNA synthetase YER102w RPS8B ribosomal protein S8.e YKR084c HBS1 translation elongation factor eEF1 YOL033w MSE1 glutamyl-tRNA synthetase, mitochondrial YBR146w MRPS9 ribosomal protein S9, mitochondrial α subunit homologue YBR121c GRS1 glycine-tRNA ligase YPL081w RPS13B ribosomal protein S9.e.A YPR080w TEF1 translation elongation factor eEF1 YPR033c HTS1 histidine-tRNA ligase, mitochondrial YBR189w SUP46 ribosomal protein S9.e.B α-A subunit, cytosolic YPL040c ISM1 isoleucine-tRNA ligase, mitochondrial YGR085c RPL16B ribosomal protein YL16.B YBR118w TEF2 translation elongation factor eEF1 YBL076c ILS1 isoleucyl-tRNA synthetase YKR006c MRPL13 ribosomal protein YmL13, mitochondrial α-A subunit, cytosolic YPL160w CDC60 leucine-tRNA ligase, cytosolic YNL005c MRPL2 ribosomal protein YmL2, mitochondrial YPL048w CAM1 translation elongation factor eEF1, YLR382c NAM2 leucine-tRNA ligase, mitochondrial YKR085c MRPL20 ribosomal protein YmL20, mitochondrial α subunit YDR037w KRS1 lysyl-tRNA synthetase, cytosolic YBR282w MRPL27 ribosomal protein YmL27, mitochondrial YKL081w TEF4 translation elongation factor eEF1, YNL073w MSK1 lysyl-tRNA synthetase, mitochondrial YDR462w ribosomal protein YmL28, mitochondrial γ subunit YGR264c MES1 methionyl-tRNA synthetase YNL252c ribosomal protein YmL30, mitochondrial YAL003w EFB1 translation elongation factor eEF1β YGR171c MSM1 methionyl-tRNA synthetase YKL138c MRPL31 ribosomal protein YmL31, mitochondrial YOR133w EFT1 translation elongation factor eEF2 YPR047w MSF1 phenylalanine-tRNA ligase α subunit, YCR003w MRPL32 ribosomal protein YmL32, mitochondrial YDR385w EFT2 translation elongation factor eEF2 mitochondrial YBR122c MRPL36 ribosomal protein YmL36, mitochondrial YLR249w YEF3 translation elongation factor eEF3 YFL022c FRS2 phenylalanine-tRNA ligase β subunit, YBR268w MRPL37 ribosomal protein YmL37, mitochondrial YNL014w translation elongation factor eEF3 cytosolic YPL173w ribosomal protein YmL40, mitochondrial homologue YLR060w FRS1 phenylalanyl-tRNA synthetase, α subunit, YMR225c MRPL44 ribosomal protein YmR44, mitochondrial YNL163c translation elongation factor eEF4 cytosolic YPL249c-a RPL39B ribosomal protein, cytoplasmic YLR069c MEF1 translation elongation factor G, YHR011w seryl-tRNA synthetase YML025c ribosomal protein, mitochondrial mitochondrial YDR023w SES1 seryl-tRNA synthetase, cytosolic YDR347w MRP1 ribosomal protein, mitochondrial YOR187w TUF1 translation elongation factor TU, YNL247w similarity to cysteinyl-tRNA synthetases YGR084c MRP13 ribosomal protein, mitochondrial mitochondrial YER087w similarity to E. coli prolyl-tRNA synthetase YKL003c MRP17 ribosomal protein, mitochondrial YJL102w MEF2 translation elongation factor, YDR341c strong similarity to arginine-tRNA ligase YDR405w MRP20 ribosomal protein, mitochondrial mitochondrial and mitochondrial arginyl-tRNA YHL004w MRP4 ribosomal protein, mitochondrial YOL023w IFM1 translation initiation factor 2, mitochondrial synthetase YKL167c MRP49 ribosomal protein, mitochondrial YNL244c SUI1 translation initiation factor 3 (eIF3) YGL245w strong similarity to glutamine-tRNA ligase YKL142w MRP8 ribosomal protein, mitochondrial YKR059w TIF1 translation initiation factor 4A YPR081c strong similarity to glycyl-tRNA YLR312w-a MRPL15 ribosomal protein, mitochondrial YMR260c TIF11 translation initiation factor eIF1A synthetases YBL038w MRPL16 ribosomal protein, mitochondrial YPL237w SUI3 translation initiation factor eIF2 β subunit YHR020w strong similarity to human glutamyl-prolyl- YMR193w MRPL24 ribosomal protein, mitochondrial YJR007w SUI2 translation initiation factor eIF2, α subunit tRNA synthetase YMR024w MRPL3 ribosomal protein, mitochondrial YER025w GCD11 translation initiation factor eIF2, γ subunit YKL194c MST1 threonine-tRNA ligase, mitochondrial YMR286w MRPL33 ribosomal protein, mitochondrial YKR026c GCN3 translation initiation factor eIF2B, 34K, YIL078w THS1 threonyl tRNA synthetase, cytosolic YLR439w MRPL4 ribosomal protein, mitochondrial α subunit YOL097c WRS1 tryptophan-tRNA ligase YHR147c MRPL6 ribosomal protein, mitochondrial YLR291c GCD7 translation initiation factor eIF2B, 43K YDR268w MSW1 tryptophanyl-tRNA synthetase, YGR220c MRPL9 ribosomal protein, mitochondrial subunit mitochondrial YDR337w MRPS28 ribosomal protein, mitochondrial YGR083c GCD2 translation initiation factor eIF2B, 71K (δ) YPL097w MSY1 tyrosyl-tRNA synthetase YNL137c NAM9 ribosomal protein, mitochondrial subunit YGR185c TYS1 tyrosyl-tRNA synthetase YOR158w PET123 ribosomal protein, mitochondrial YDR211w GCD6 translation initiation factor eIF2B, ε 81K YGR094w VAS1 valyl-tRNA synthetase YCR046c PETCR46 ribosomal protein, mitochondrial subunit YFR049w YMR31 ribosomal protein, mitochondrial YOR260w GCD1 translation initiation factor eIF2B, γ subunit other protein-synthesis activities YJR113c similarity to mitochondrial ribosomal YOR361c PRT1 translation initiation factor eIF3 subunit protein S7 YMR146c TIF34 translation initiation factor eIF3, P39 YDL229w SSB1 heat-shock protein of HSP70 family YHR148w similarity to ribosomal protein subunit YNL209w SSB2 heat-shock protein of HSP70 family, YDR116c similarity to ribosomal protein L1 YNL062c GCD10 translation initiation factor eIF3, RNA- cytosolic YOR150w similarity to ribosomal protein L13 binding subunit YGR147c NAT2 N-acetyltransferase for N-terminal YNL284c similarity to ribosomal protein L15 YJL138c TIF2 translation initiation factor eIF4A methionine YEL050c similarity to ribosomal protein L2 YPR163c TIF3 translation initiation factor eIF4B YJR066w TOR1 phosphatidylinositol 3-kinase YLR009w similarity to ribosomal protein L24.e.B YOL139c CDC33 translation initiation factor eIF4E YDL044c MTF2 protein involved in mRNA splicing and YDR115w similarity to ribosomal protein L34 YPR041w TIF5 translation initiation factor eIF5 protein synthesis, mitochondrial YDR237w similarity to ribosomal protein L5 YEL034w HYP2 translation initiation factor eIF5A.1 YDL040c NAT1 protein N-acetyltransferase subunit YNL081c similarity to ribosomal protein S13 YJR047c ANB1 translation initiation factor eIF5A.2 YJL023c PET130 protein synthesis protein, mitochondrial YDR041w similarity to ribosomal proteins YGL169w SUA5 translation initiation protein YMR005w MPT1 required for protein synthesis YKL009w similarity to Rpl10p and S.solfataricus YBR143c SUP45 translational release factor YBL080c PET112 required to maintain RHO+ mitochondrial ribosomal protein L10 DNA YDL208w NHP2 strong similarity to high-mobility group translational control YHR189w similarity to peptidyl-tRNA hydrolases (HMG) family YLL039c UBI4 ubiquitin YEL026w strong similarity to high-mobility group-like YMR282c AEP2 2’-O-ribosyl phosphate transferase protein Nhp2p YBR120c CBP6 apo-cytochrome b pre-mRNA processing YOR182c RPS30B strong similarity to human ubiquitin-like protein protein/ribosomal protein S30 YPL029w SUV3 ATP-dependent RNA helicase, Protein destination YNR037c strong similarity to Mycoplasma mitochondrial ribosomal protein S19 YOR017w PET127 component of mitochondrial translation protein folding and stabilization YNL185c strong similarity to ribosomal protein L11 system YER056c-a strong similarity to ribosomal protein YMR028w TAP42 component of the Tor signalling pathway YEL030w heat-shock protein of HSP70 family L34.e YDR197w CBS2 cytochrome b translational activator YKL073w LHS1 chaperone of the ER lumen YMR230w strong similarity to ribosomal protein S10 protein YIL142w CCT2 chaperonin of the TCP1 ring complex, YNR036c strong similarity to ribosomal protein S12 YNL216w RAP1 DNA-binding protein with repressor and cytosolic YNL096c strong similarity to ribosomal protein S7 activator activity YJL014w CCT3 chaperonin of the TCP1 ring complex, YLR167w UBI3 ubiquitin/ribosomal protein S27a YER054c GIP2 Glc7p-interacting protein cytosolic YMR188c weak similarity to 30S ribosomal protein YMR080c NAM7 nonsense-mediated mRNA decay protein YDR212w CCT1 component of chaperonin-containing S17 YGR072w UPF3 nonsense-mediated mRNA decay protein T-complex YDL202w weak similarity to ribosomal protein YHR077c NMD2 nonsense-mediated mRNA decay protein YDL143w CCT4 component of chaperonin-containing 2 T-complex translation (initiation, elongation and YMR064w AEP1 nuclear control of ATPase messenger YJL111w CCT7 component of chaperonin-containing termination) RNA expression protein T-complex YPL179w PPQ1 phosphoprotein phosphatase YJL008c CCT8 component of chaperonin-containing YDL081c RPLA1 acidic ribosomal protein a1 YFR009w GCN20 positive effector of Gcn2p T-complex YMR309c NIP1 associated with 40s ribosomal subunit YLR203c MSS51 possibly involved in translational YDR188w CCT6 component of chaperonin-containing YGL094c PAN2 component of Pab1p-stimulated poly(A) activation of COX1 and COB mRNA T-complex (ζ subunit) ribonuclease YBL058w SHP1 potential regulatory subunit for Glc7p YDR155c CPH1 cyclophilin (peptidylprolyl isomerase) YDR172w SUP35 eukaryotic peptide chain release factor YNL139c RLR1 regulatory protein YML078w CPR3 cyclophilin (peptidylprolyl isomerase), GTP-binding subunit YLR067c PET309 required for stability and translation of mitochondrial YNL007c SIS1 heat-shock protein COX1 mRNA YOR288c MPD1 disulphide isomerase related protein YBL091c MAP2 methionine aminopeptidase, isoform 2 YMR257c PET111 required for translation of COX2 mRNA YER048c CAJ1 dnaJ homologue YMR023c MSS1 mitochondrial GTPase involved in YER133w GLC7 ser/thr phosphoprotein phosphatase 1, YDR519w FKB2 FK506/rapamycin-binding protein of the expression of COX1 catalytic subunit ER YGL143c MRF1 mitochondrial peptide chain release factor YOR178c GAC1 ser/thr phosphoprotein phosphatase 1, YFL016c MDJ1 heat-shock protein - chaperone YGL049c TIF4632 mRNA cap-binding protein (eIF4F), 130K regulatory subunit YOR232w MGE1 heat-shock protein - chaperone subunit YDR283c GCN2 ser/thr protein kinase YLR259c HSP60 heat-shock protein - chaperone, YGR162w TIF4631 mRNA cap-binding protein (eIF4F), 150K YGR222w PET54 splicing protein and translational activator, mitochondrial subunit mitochondrial YJR045c SSC1 heat-shock protein 70-related protein, YOR276w CAF20 mRNA CAP-binding protein (eIF4F), 20K YBR024w SCO2 strong similarity to Sco1p mitochondrial subunit YGL195w GCN1 translational activator YAL005c SSA1 heat-shock protein of HSP70 family YER165w PAB1 mRNA polyadenylate-binding protein YDL069c CBS1 translational activator of cob mRNA YLL024c SSA2 heat-shock protein of HSP70 family, YKL173w GIN10 similarity to elongation factor 2 eFT1 YER153c PET122 translational activator of cytochrome c cytosolic YHR015w similarity to PES4 PAB-like protein oxidase subunit III YDR171w HSP42 heat-shock protein with similarity to YGR201c similarity to Tef3p and Tef4p YNR045w PET494 translational activator, mitochondrial Hsp26p YPL226w similarity to translation elongation factor YJL125c GCD14 translational repressor of GCN4 YLR216c CPR6 member of the cyclophilin family eEF3 YJR032w CPR7 member of the cyclophilin family YJL034w KAR2 nuclear fusion protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 49 gazetteer

YHR057c CYP2 peptidyl-prolyl cis-trans isomerase YBR162w-a YSY6 secretory pathway protein YKL134c (MIP1) mitochondrial intermediate peptidase YCR069w SCC3 peptidyl-prolyl cis-trans isomerase YBR097w VPS15 ser/thr protein kinase YLR163c MAS1 mitochondrial processing peptidase YDR304c CYP5 peptidyl-prolyl cis-trans isomerase D YPL243w SRP68 signal recognition particle protein YHR024c MAS2 mitochondrial processing peptidase, (cyclophilin D) of the ER YPL210c SRP72 signal recognition particle protein catalytic 53K (α) subunit YNL135c FPR1 peptidyl-prolyl cis-trans isomerase, FK506- YDR292c SRP101 signal recognition particle receptor, α YMR150c IMP1 mitochondrial protease binding protein subunit YPR051w MAK3 N-acetyltransferase YML074c NPI46 proline cis-trans isomerase YML105c SEC65 signal recognition particle subunit YGR147c NAT2 N-acetyltransferase for N-terminal YDR518w EUG1 protein disulphide isomerase YDL092w SRP14 signal recognition particle subunit methionine YCL043c PDI1 protein disulphide-isomerase YKL122c SRP21 signal recognition particle subunit YBR247c ENP1 N-glycosylation protein YJR097w similarity to Caj1p YPR088c SRP54 signal recognition particle subunit YLR195c NMT1 N-myristoyltransferase YBR044c similarity to chaperonin HSP60 proteins YOR285w similarity to D. melanogaster heat-shock YJL002c OST1 oligosaccharyltransferase α subunit YOL088c similarity to disulphide isomerases and protein 67B2 YEL002c WBP1 oligosaccharyltransferase β subunit ER60 proteases YOR286w similarity to D. melanogaster heat-shock YMR149w SWP1 oligosaccharyltransferase δ subunit YNL077w similarity to dnaJ protein homologue YDJ1 protein 67B2 YOR103c OST2 oligosaccharyltransferase ε subunit YMR161w HLJ1 similarity to dnaJ proteins YHR110w similarity to human gp25L2 protein YOR085w OST3 oligosaccharyltransferase γ subunit YIR004w similarity to DNAJ-like proteins YAR002c-a similarity to mammalian gp25L protein YDL232w OST4 oligosaccharyltransferase subunit YLR090w XDJ1 similarity to E. coli dnaJ YKL154w similarity to mouse signal recognition YGL022w STT3 oligosaccharyltransferase subunit YJL073w similarity to heat-shock proteins particle receptor β subunit YFL045c SEC53 phosphomannomutase YNR028w similarity to peptidylprolyl isomerase YKL196c similarity to Sec22p YPR122w AXL1 protease Scc3p YMR018w similarity to tetratricopeptide-repeat YEL060c PRB1 protease B, vacuolar YIL005w similarity to protein disulphide isomerases protein PAS10 YLR389c STE23 protease involved in a-factor processing YLR369w strong similarity to heat-shock protein 70- YMR214w SCJ1 similarity to to E. coli dnaJ YCL043c PDI1 protein disulphide-isomerase related proteins YNL304w similarity to Ypt1p and other GTP-binding YKL019w RAM2 protein farnesyltransferase, α subunit YLR449w strong similarity to peptidylprolyl proteins YDL090c RAM1 protein farnesyltransferase, β subunit isomerase FRP3 YER101c AST2 strong similarity to Ast1p YHR013c ARD1 protein N-acetyltransferase subunit YJR064w CCT5 T-complex protein 1, ε subunit YOR016c strong similarity to FUN54 protein, YDL040c NAT1 protein N-acetyltransferase subunit YFR041c weak similarity to dnaJ-like heat-shock similarity to hamster COP-coated vesicle YIL085c KTR7 putative α-1,2-mannosyltransferase proteins membrane protein YGL194c RTL1 putative deacetylase YNL227c weak similarity to dnaJ-like proteins YGL002w strong similarity to human gp25L2 protein YNL029c KTR5 putative mannosyltransferase YER087c-a SEB1 strong similarity to mammalian Sec61β YGR199w PMT6 putative mannosyltransferase protein targeting, sorting and translocation subunit YKL193c SDS22 regulatory subunit for the mitotic function YCR099c strong similarity to Pep1p of type I protein phosphatase YKL073w LHS1 chaperone of the ER lumen YCR100c strong similarity to Pep1p YNL048w ALG11 required for asparagine-linked YGL206c CHC1 clathrin heavy chain YCR101c strong similarity to Pep1p glycosylation YOL062c APM4 clathrin-associate protein YAP54 YIL173w strong similarity to Pep1p YLR088w GAA1 required for attachment of GPI anchor YPL259c APM1 clathrin-associated protein YJL222w strong similarity to Pep1p onto proteins YBR288c APM3 clathrin-associated protein complex, YBR283c strong similarity to Sec61p YPL050c MNN9 required for complex N-glycosylation medium subunit YOR327c SNC2 strong similarity to synaptobrevin YJR010c-a SPC1 signal peptidase 10.8K subunit YDL212w SHR3 endoplasmic reticulum membrane protein YOR329c SCD5 suppressor of clathrin deficiency YML055w SPC2 signal peptidase 18K subunit YBL040c ERD2 ER lumen protein-retaining receptor YHR050w SMF2 suppressor of mitochondrial matrix YIR022w SEC11 signal sequence processing protein YER019c-a SEB2 ER protein-translocation complex subunit mutant YDL042c SIR2 silencing regulatory protein YLR378c SEC61 ER protein-translocation complex subunit YOR036w PEP12 syntaxin (T-SNARE) YER005w similarity to Gda1p YPL094c SEC62 ER protein-translocation complex subunit YLR148w PEP3 vacuolar membrane protein YMR223w similarity to human putative ubiquitin YOR254c SEC63 ER protein-translocation complex subunit YBL017c PEP1 vacuolar protein sorting/targeting protein carboxyl-terminal hydrolase YBR171w SEC66 ER protein-translocation complex subunit YJL053w PEP8 vacuolar protein sorting/targeting protein YDR098c similarity to Legionella glutaredoxin-like YLR292c SEC72 ER protein-translocation complex subunit YOR132w VPS17 vacuolar protein sorting-associated protein YDR086c SSS1 ER protein-translocation complex subunit protein YER174c similarity to Legionella glutaredoxin-like YOR089c VPS21 GTP-binding protein YNR006w VPS27 vacuolar protein sorting-associated protein YKR014c YPT52 GTP-binding protein of the RAB family protein YGL257c similarity to Mnn1p YNL093w YPT53 GTP-binding protein of the RAB family YGL095c VPS45 vacuolar protein sorting-associated YIL014w similarity to Mnn1p (RAS superfamily) protein YPR131c similarity to N-acetyltransferases YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YJL154c VPS35 vacuolar protein-sorting protein YDL093w PMT5 similarity to O-mannosyltransferases vacuolar YDR323c PEP7 vacuolar segregation protein Pmt1p-Pmt4p YAL005c SSA1 heat-shock protein of HSP70 family YPL045w VPS16 vacuolar sorting protein YDR307w similarity to Pmt1p YCR075c ERS1 intracellular protein transport protein YDR495c VPS3 vacuolar sorting protein YDR245w MNN10 similarity to S. pombe YGR028w MSP1 intra-mitochondrial sorting protein YLR396c VPS33 vacuolar sorting protein galactosyltransferase YOR069w VPS5 involved in Golgi retention and vacuolar YAL002w VPS8 vacuolar sorting protein YLR066w similarity to signal peptidase sorting YML097c VPS9 vacuolar sorting protein YNR059w similarity to to α-1,3-mannosyltransferase YLR347c KAP95 karyopherin-β YPL003w similarity to ubiquitin-activating enzymes YOL122c SMF1 manganese transporter protein modification (glycosylation, acylation, YPR180w similarity to ubiquitin-activating enzymes YKR001c VPS1 member of the dynamin family of myristylation, palmitylation, farnesylation and YGL087c similarity to ubiquitin-protein ligase GTPases processing) YIR039c similarity to Yap3p YOR020c HSP10 mitochondrial chaperonin YBR205w KTR3 strong similarity to α-1,2- YNR017w MAS6 mitochondrial inner membrane import YJR131w MNS1 α-1,2-mannosidase mannosyltransferase translocase subunit YDR483w KRE2 α-1,2-mannosyltransferase YBR199w KTR4 strong similarity to α-1,2- YJL143w TIM17 mitochondrial inner membrane import YER001w MNN1 α-1,3-mannosyltransferase mannosyltransferase translocase subunit YGL038c OCH1 α-1,6-mannosyltransferase YPL053c KTR6 strong similarity to α-1,2- YIL022w TIM44 mitochondrial inner membrane import YBR164c ARL1 ADP-ribosylation factor mannosyltransferase Kre2p translocase subunit YKL157w APE2 aminopeptidase yscII YPL051w strong similarity to ADP-ribosylation YMR035w IMP2 mitochondrial inner membrane protease YJR062c NTA1 amino-terminal amidase factors subunit YGL017w ATE1 arginyl tRNA transferase YLR121c strong similarity to aspartylproteases YNL131w TOM22 mitochondrial outer membrane import YPL154c PEP4 aspartyl protease YOR099w KTR1 strong similarity to mannosyltransferases receptor subunit YLR120c YAP3 aspergillopepsin YCR083w strong similarity to thioredoxin YGR082w TOM20 mitochondrial outer membrane import YDL141w BPL1 biotin holocarboxylase synthetase YOR339c strong similarity to ubiquitin conjugating receptor subunit, 20K YBR110w ALG1 β-mannosyltransferase enzymes YMR060c TOM37 mitochondrial outer membrane import YGL203c KEX1 carboxypeptidase (YSC-α) YPR066w strong similarity to ubiquitin-activating receptor subunit, 37K YPL227c ALG5 dolichol-P-glucose synthetase enzymes YMR203w TOM40 mitochondrial outer membrane import YJR143c PMT4 dolichyl-phosphate-mannose-protein YML111w strong similarity to ubiquitination protein receptor subunit, 40K O-mannosyl transferase Bul1p YOR045w TOM6 mitochondrial outer membrane import YDL212w SHR3 endoplasmic reticulum membrane protein YGL226c-a OST5 subunit of N-oligosaccharyltransferase, receptor subunit, 6K YNL238w KEX2 endoproteinase of late Golgi ζ subunit YNL070w TOM7 mitochondrial outer membrane import compartment YEL056w HAT2 subunit of the major yeast histone receptor subunit, 7K YDR331w GPI8 essential for GPI-anchor attachment acetyltransferase YNL121c TOM70 mitochondrial outer membrane YDR410c STE14 farnesyl cysteine carboxyl- YJR075w HOC1 suppressor of pkc1 specialized import receptor methyltransferase YLR043c TRX1 thioredoxin I YMR150c IMP1 mitochondrial protease YOR370c MSI4 geranylgeranyltransferase regulatory YGR209c TRX2 thioredoxin II YJL034w KAR2 nuclear fusion protein subunit YOR219c STE13 type IV dipeptidyl aminopeptidase YMR091c NPL6 nuclear protein localization factor YGL155w CDC43 geranylgeranyltransferase type I β subunit YMR275c BUL1 ubiquitination pathway protein YBR170c NPL4 nuclear protein localization factor and ER YPR176c BET2 geranylgeranyltransferase type II β subunit YDR054c CDC34 ubiquitin-conjugating enzyme translocation component YJL031c BET4 geranylgeranyltransferase, α subunit YGR133w PAS2 ubiquitin-conjugating enzyme YDR432w NPL3 nucleolar protein YOR002w ALG6 glucosyltransferase YMR022w QRI8 ubiquitin-conjugating enzyme YLR191w PAS20 peroxisomal protein involved in protein YOR067c ALG8 glucosyltransferase YGL058w RAD6 ubiquitin-conjugating enzyme import YEL042w GDA1 guanosine diphosphatase YDR177w UBC1 ubiquitin-conjugating enzyme YPR047w MSF1 phenylalanine-tRNA ligase α subunit, YGR252w GCN5 histone acetyltransferase YLR306w UBC12 ubiquitin-conjugating enzyme mitochondrial YPL001w HAT1 histone acetyltransferase subunit YDR092w UBC13 ubiquitin-conjugating enzyme YNL106c PIE3 phosphatidylinositol phosphate YBR034c HMT1 hnRNP methyltransferase YDR059c UBC5 ubiquitin-conjugating enzyme phosphatase YAL039c CYC3 holocytochrome c synthase (cytochrome YER100w UBC6 ubiquitin-conjugating enzyme YBL069w AST1 PMA1 protein targeting protein c heme lyase) YEL012w UBC8 ubiquitin-conjugating enzyme YLR168c (MSF1) probably involved in intramitochondrial YKL087c CYT2 holocytochrome c1 synthase YDL064w UBC9 ubiquitin-conjugating enzyme protein sorting YGL065c ALG2 mannosyltransferase YDR139c ubiquitin-like protein YDR244w PAS10 putative peroxisomal targeting signal YDL095w PMT1 mannosyltransferase YER125w RSP5 ubiquitin-protein ligase receptor YAL023c PMT2 mannosyltransferase YKL210w UBA1 ubiquitin-protein ligase YCL001w RER1 required for correct localization of Sec12p YOR321w PMT3 mannosyltransferase YJR099w YUH1 ubiquitin-specific protease YDR414c ERD1 required for retention of luminal ER YBL082c RHK1 mannosyltransferase YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate proteins YLR244c MAP1 methionine aminopeptidase, isoform 1 transferase YDR005c MAF1 required for sorting of Mod5p YBL091c MAP2 methionine aminopeptidase, isoform 2 YKL035w UGP1 UTP-glucose-1-phosphate YMR004w MVP1 required for vacuolar protein sorting YMR035w IMP2 mitochondrial inner membrane protease uridylyltransferase YDR498c SEC20 secretory pathway protein subunit YDR495c VPS3 vacuolar sorting protein

50 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YJR117w STE24 zinc metallo-protease YGR105w VMA21 vacuolar ATPase assembly integral YDR054c CDC34 ubiquitin-conjugating enzyme membrane protein YMR022w QRI8 ubiquitin-conjugating enzyme assembly of protein complexes YHR060w VMA22 vacuolar ATPase assembly protein YDR177w UBC1 ubiquitin-conjugating enzyme YDR495c VPS3 vacuolar sorting protein YLR306w UBC12 ubiquitin-conjugating enzyme YGR214w NAB1A 40S ribosomal protein p40 homologue A YDR092w UBC13 ubiquitin-conjugating enzyme YLR048w NAB1B 40S ribosomal protein p40 homologue B proteolysis YBR082c UBC4 ubiquitin-conjugating enzyme YPL195w YKS4 α- or γ- adaptin, large subunit of the YDR059c UBC5 ubiquitin-conjugating enzyme clathrin-associated protein(AP) complex YPL149w APG5 involved in autophagy and nutrient YER100w UBC6 ubiquitin-conjugating enzyme YBL037w APL3 α-adaptin, large subunit of the clathrin- starvation YDL064w UBC9 ubiquitin-conjugating enzyme associated protein(AP) complex YOL013c HRD1 involved in degradation of Hmg2p YDR139c ubiquitin-like protein YOR094w ARF3 ADP-ribosylation factor 3 YLR207w HRD3 involved in degradation of Hmg2p YER125w RSP5 ubiquitin-protein ligase YBL022c PIM1 ATP-dependent protease, mitochondrial YMR174c PAI3 protease A (ysca) inhibitor IA3 YKL210w UBA1 ubiquitin-protein ligase YKL135c APL2 β-adaptin YNL015w PBI2 proteinase B inhibitor 2 YGR184c UBR1 ubiquitin-protein ligase YGR261c YKS5 β-adaptin, large subunit of the clathrin- YCL052c PBN1 required for Prb1p expression YDR069c DOA4 ubiquitin-specific protease associated protein(AP) complex YHR132c similarity to carboxypeptidase YDL122w UBP1 ubiquitin-specific protease YBR195c MSI1 chromatin assembly complex, subunit YNR069c similarity to central part of Bul1p YER144c UBP5 ubiquitin-specific protease p50 YBR227c similarity to E. coli ATP-binding protein YJR099w YUH1 ubiquitin-specific protease YPR018w RLF2 chromatin assembly complex, subunit clpX YOR124c UBP2 ubiquitin-specific proteinase p90 YNL186w similarity to human putative ubiquitin YER151c UBP3 ubiquitin-specific proteinase YLR170c APS1 clathrin-associated protein (AP) complex, carboxy-terminal hydrolase small subunit AP19 YIL137c similarity to M. musculus aminopeptidase lysosomal and vacuolar degradation YJR058c APS2 clathrin-associated protein 17, small YKR038c similarity to Qri7p YBR286w APE3 aminopeptidase Y, vacuolar subunit YER047c similarity to regulatory subunit Yta6p of YKL103c LAP4 aminopeptidase yscI, vacuolar YJR005w YAP80 clathrin-associated protein complex, 26S proteasome YPL154c PEP4 aspartyl protease β subunit YCR045c similarity to serin proteases YMR297w PRC1 carboxypeptidase y, serine-type protease YJL024c APS3 clathrin-associated protein(AP) complex, YER078c similarity to X-Pro aminopeptidase II YHR028c DAP2 dipeptidyl aminopeptidase B small subunit YBR139w strong similarity to carboxypeptidase YJL172w CPS1 Gly-X carboxypeptidase YSCS YER058w PET117 cytochrome c oxidase assembly factor YBL067c UBP13 ubiquitin carboxyl-terminal hydrolase YEL060c PRB1 protease B, vacuolar YPL132w COX11 cytochrome c oxidase assembly protein YOL111c weak similarity to human ubiquitin-like YOR003w YSP3 subtilisin-like protease III YML129c COX14 cytochrome c oxidase assembly protein protein GDX YDR079w PET100 cytochrome c oxidase assembly protein other subcellular degradation YLR038c COX12 cytochrome c oxidase subunit VIB cytoplasmic degradation YDR144c MKC7 aspartyl protease of the periplasmic YMR256c COX7 cytochrome c oxidase subunit VII YFR052w NIN1 26S proteasome regulatory subunit space YDL067c COX9 cytochrome c oxidase subunit VIIA YIL075c SEN3 26S proteasome regulatory subunit YBL022c PIM1 ATP-dependent protease, mitochondrial YER141w COX15 cytochrome oxidase assembly factor YOR259c CRL13 26S proteasome subunit YIL015w BAR1 barrierpepsin YER154w OXA1 cytochrome oxidase biogenesis protein YPR103w PRE2 26S proteasome subunit YBR201w DER1 involved in degradation proteins in the ER YBL007c SLA1 cytoskeleton assembly control protein YFR050c PRE4 26S proteasome subunit YER017c AFG3 protease of the SEC18/CDC48/PAS1 YNL243w SLA2 cytoskeleton assembly control protein YOR157c PUP1 26S proteasome subunit family of ATPases (AAA) YLR393w ATP10 F1F0 ATPase complex assembly protein YGR253c PUP2 26S proteasome subunit YPR024w YME1 protease of the SEC18/CDC48/PAS1 YNL315c ATP11 F1F0-ATPase complex assembly protein YER094c PUP3 26S proteasome subunit family of ATPases (AAA) YJL180c ATP12 F1F0-ATPase complex assembly protein YGL048c SUG1 26S proteasome subunit YMR089c YTA12 protease of the SEC18/CDC48/PAS1 YPL172c COX10 farnesyl transferase YHR200w SUN1 26S proteasome subunit family of ATPases (AAA) YPL231w FAS2 fatty-acyl-CoA synthase, α subunit YER021w SUN2 26S proteasome subunit YCL057w PRD1 proteinase yscD YPR029c APL4 γ-adaptin, large subunit of the clathrin- YOR117w YTA1 26S proteasome subunit YHR113w similarity to vacuolar aminopeptidase associated protein(AP) complex YDR394w YTA2 26S proteasome subunit Lap4p/Ape1p YDL192w ARF1 GTP-binding protein of the ARF family YKL145w YTA3 26S proteasome subunit YFR006w similarity to X-Pro dipeptidases YDL137w ARF2 GTP-binding protein of the ARF family YGR270w YTA7 26S proteasome subunit YKL119c VPH2 H+-ATPase assembly protein, vacuolar YOR362c PRE10 26S proteasome subunit C1 other protein-destination activities YPL234c TFP3 H+-ATPase V0 domain 17K subunit, YER012w PRE1 26S proteasome subunit C11 vacuolar YGR135w PRE9 26S proteasome subunit Y13 YDR258c HSP78 heat-shock protein of clpb family of ATP- YLR447c VMA6 H+-ATPase V0 domain 36K subunit, YML092c PRE8 26S proteasome subunit Y7 dependent proteases, mitochondrial vacuolar YGL011c SCL1 26S proteasome subunit YC7α/Y8 YDL104c QRI7 similarity to H. influenzae YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YMR314w PRE5 26S proteasome subunit, α-type sialoglycoprotease (gcp) vacuolar YNL239w LAP3 aminopeptidase of cysteine protease YDR415c strong similarity to bacterial leucyl YOR332w VMA4 H+-ATPase V1 domain 27K subunit, family aminopeptidase vacuolar YJR062c NTA1 amino-terminal amidase YKL080w VMA5 H+-ATPase V1 domain 42K subunit, YGL017w ATE1 arginyl tRNA transferase vacuolar YDL132w CDC53 controls G1/S transition YLL009c COX17 interacts genetically with SCO1 and SCO2 YLR452c SST2 involved in desensitization to α-factor Transport facilitation in cytochrome oxidase assembly pheromone YJR034w PET191 involved in assembly of cytochrome YKL213c DOA1 involved in ubiquitin-dependent ion channels oxidase proteolysis YBR037c SCO1 involved in stabilization of Cox1p and YDL126c CDC48 microsomal protein of YGR217w CCH1 calcium channel protein Cox2p CDC48/PAS1/SEC18 family of ATPases YLL052c member of mip family transmembrane YDR375c BCS1 mitochondrial protein of the YJL001w PRE3 multicatalytic endopeptidase complex channels CDC48/PAS1/SEC18 (AAA) family of subunit YJL093c TOK1 outward-rectifier potassium channel ATPases YOL038w PRE6 multicatalytic endopeptidase complex YPR192w similarity to plasma membrane and water YPL085w SEC16 multidomain vesicle coat protein subunit channel proteins YKR048c NAP1 nucleosome assembly protein I YBL041w PRE7 multicatalytic endopeptidase complex YLL053c similarity to water channel proteins YML102w CAC2 p60 subunit of the chromatin assembly subunit YIL114c POR2 voltage-dependent anion channel factor-I (CAF-I) YDL020c SON1 nuclear protein (YVDAC2) YKL197c PAS1 peroxisomal assembly protein YBR165w UBS1 positive regulator of Cdc34p YJR040w GEF1 voltage-gated chloride channel protein YDR265w PAS4 peroxisomal assembly protein YDL007w YTA5 probable component of 26S proteasome YNL329c PAS8 peroxisomal assembly protein complex ion transporters YBR237w PRP5 pre-mRNA processing RNA-helicase YIL148w UBI1 ribosomal protein YJL203w PRP21 pre-mRNA splicing factor YKR094c UBI2 ribosomal protein YNR055c HOL1 member of major facilitator superfamily YER017c AFG3 protease of the SEC18/CDC48/PAS1 YMR223w similarity to human putative ubiquitin multidrug-resistance protein subfamily 1 family of ATPases (AAA) carboxyl-terminal hydrolase YIL048w similarity to amino-phospholipids-ATPase YPR024w YME1 protease of the SEC18/CDC48/PAS1 YDR390c UBA2 similarity to Uba1p Drs2p family of ATPases (AAA) YPL003w similarity to ubiquitin-activating enzymes YMR089c YTA12 protease of the SEC18/CDC48/PAS1 YPR180w similarity to ubiquitin-activating enzymes metal ion transporters (Cu, Fe, etc.) family of ATPases (AAA) YGL087c similarity to ubiquitin-protein ligase YOR316c COT1 cobalt accumulation protein YPL215w CBP3 required for assembly of cytochrome bc1 YPL074w YTA6 similarity to Vps4p and Yta4p YPR124w CTR1 copper transport protein complex YOR261c strong similarity to human 26S YHR175w CTR2 copper transport protein YBR185c MBA1 respiratory chain assembly protein proteasome regulatory subunit, p40 YLR411w CTR3 copper transport protein YLL008w DRS1 RNA helicase of the DEAD box family YOR339c strong similarity to ubiquitin conjugating YGL255w ZRT1 high-affinity zinc transport protein YBR227c similarity to E. coli ATP-binding protein enzymes YLR130c ZRT2 low-affininty zinc transporter clpX YPR066w strong similarity to ubiquitin-activating YMR319c FET4 low-affinity Fe(II) iron transport protein YGR241c similarity to rat clathrin assembly protein enzymes YOL122c SMF1 manganese transporter YHR161c similarity to rat clathrin assembly protein YML111w strong similarity to ubiquitination protein YBR290w BSD2 metal homeostasis protein AP180 Bul1p YDR270w CCC2 probable copper-transporting ATPase YGR074w SMD1 snRNA-associated protein YHR027c HRD2 subunit of 26S proteasome YBR295w PCA1 P-type Cu2+-transporting ATPase YBR024w SCO2 strong similarity to Sco1p YKL022c CDC16 subunit of anaphase-promoting complex YMR243c ZRC1 zinc- and cadmium resistance protein YLR327c strong similarity to STF2p (cyclosome) YOR134w BAG7 structural homologue of Sac7p YHR166c CDC23 subunit of anaphase-promoting complex other cation transporters (Na, K, Ca, NH4, etc.) YDR389w SAC7 suppressor of actin mutation (cyclosome) YGR121c MEP1 ammonia permease of high capacity and YOR106w VAM3 syntaxin related protein YBL084c CDC27 subunit of anaphase-promoting complex moderate affinity YDR460w TFB3 TFIIH subunit (transcription/repair factor) (cyclosome) YDL128w VCX1 Ca2+-transport (H+/Ca2+ exchange) protein, YPR178w PRP4 U4/U6 snRNP 52K protein YLL039c UBI4 ubiquitin vacuolar YGL119w ABC1 ubiquinol cytochrome c reductase YIL156w UBP7 ubiquitin carboxy terminal hydrolase YGL006w PMC1 Ca2+-transporting P-type ATPase complex assembly protein YER098w UBP9 ubiquitin carboxyl-terminal hydrolase YGL167c PMR1 Ca2+-transporting P-type ATPase YPR191w QCR2 ubiquinol-cytochrome c reductase 40K YKR098c UBP11 ubiquitin C-terminal hydrolase YCR024c-a PMP1 H+-ATPase subunit, plasma membrane subunit II YJL197w UBP12 ubiquitin C-terminal hydrolase YEL017c-a PMP2 H+-ATPase subunit, plasma membrane YGR174c CBP4 ubiquinol-cytochrome c reductase YGR048w UFD1 ubiquitin fusion degradation protein YMR054w STV1 H+-ATPase V0 domain 102K subunit, assembly factor YDL190c UFD2 ubiquitin fusion degradation protein vacuolar YLL039c UBI4 ubiquitin YBR058c UBP14 ubiquitin specific protease YHR039c-a VMA10 H+-ATPase V0 domain 13K subunit, YGR133w PAS2 ubiquitin-conjugating enzyme YLR167w UBI3 ubiquitin/ribosomal protein S27a vacuolar YMR275c BUL1 ubiquitination pathway protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 51 gazetteer

YEL027w CUP5 H+-ATPase V0 domain 17K subunit, YCR098c GIT1 similarity to phosphate transporter YOR071c similarity to allantoin or uracil transport vacuolar proteins proteins YPL234c TFP3 H+-ATPase V0 domain 17K subunit, YDL199c similarity to sugar transporter proteins YOR192c similarity to allantoin or uracil transport vacuolar YFL040w similarity to yeast glucose transport proteins YLR447c VMA6 H+-ATPase V0 domain 36K subunit, proteins YLR237w similarity to allantoin transport protein vacuolar YHR096c HXT5 strong similarity to hexose transporters YLL055w similarity to Dal5p YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YDL245c HXT15 strong similarity to Hxt17p and Haxt7p YBL042c strong similarity to allantoin and uracil vacuolar YJR160c strong similarity to Mal3Tp transport proteins YGR020c VMA7 H+-ATPase V1 domain 14K subunit, YDR536w STL1 strong similarity to members of the sugar YAL067c SEO1 suppressor of sulphoxyde ethionine vacuolar permease family resistance YOR332w VMA4 H+-ATPase V1 domain 27K subunit, YOR271c strong similarity to Rattus tricarboxylate vacuolar carrier transport ATPases YEL051w VMA8 H+-ATPase V1 domain 32K subunit, YDL247w strong similarity to sugar transport vacuolar proteins YGL006w PMC1 Ca2+-transporting P-type ATPase YKL080w VMA5 H+-ATPase V1 domain 42K subunit, YIL171w strong similarity to sugar transport YGL167c PMR1 Ca2+-transporting P-type ATPase vacuolar proteins YKL016c ATP7 F1F0-ATPase complex, F0 D subunit YPR036w VMA13 H+-ATPase V1 domain 54K subunit, YIL170w HXT12 strong similarity to sugar transport YBL099w ATP1 F1F0-ATPase complex, F1 α subunit vacuolar proteins YJR121w ATP2 F1F0-ATPase complex, F1 β subunit YBR127c VMA2 H+-ATPase V1 domain 60K subunit, YJR158w HXT16 strong similarity to sugar transport YDL004w ATP16 F1F0-ATPase complex, F1 δ subunit vacuolar proteins YPL078c ATP4 F1F0-ATPase complex, F1 δ subunit YDL185w TFP1 H+-ATPase V1 domain 69K subunit, YNR072w HXT17 sugar transport protein YPL271w ATP15 F1F0-ATPase complex, F1 ε subunit vacuolar YDL138w RGT2 suppressor of snf3 mutant YBR039w ATP3 F1F0-ATPase complex, F1 γ subunit YGL008c PMA1 H+-transporting P-type ATPase YDR298c ATP5 F1F0-ATPase complex, OSCP subunit YPL036w PMA2 H+-transporting P-type ATPase 2 amino-acid transporters YLR295c ATP14 F1F0-ATPase complex, subunit h YNL142w MEP2 high-affinity low-capacity ammonia YCR024c-a PMP1 H+-ATPase subunit, plasma membrane permease YBR068c BAP2 amino-acid permease YEL017c-a PMP2 H+-ATPase subunit, plasma membrane YJL129c TRK1 high-affinity potassium transport protein YEL063c CAN1 amino-acid permease YMR054w STV1 H+-ATPase V0 domain 102K subunit, YAL026c DRS2 membrane-spanning P-type amino- YBR069c VAP1 amino-acid permease vacuolar phospholipids-ATPase YCL025c AGP1 asparagine and glutamine permease YHR039c-a VMA10 H+-ATPase V0 domain 13K subunit, YKR050w TRK2 moderate-affinity potassium transport YGL077c HNM1 choline permease vacuolar protein YPL265w DIP5 dicarboxylic amino-acid permease YEL027w CUP5 H+-ATPase V0 domain 17K subunit, YHR026w PPA1 proteolipid protein of proton-transporting YDL210w UGA4 GABA-specific high-affinity permease vacuolar ATPase YKR039w GAP1 general amino-acid permease YPL234c TFP3 H+-ATPase V0 domain 17K subunit, YEL031w SPF1 P-type ATPase YDR508c GNP1 high-affinity glutamine permease vacuolar YLR138w NHA1 putative Na+/H+ antiporter YGR055w MUP1 high-affinity methionine permease YLR447c VMA6 H+-ATPase V0 domain 36K subunit, YBR235w similarity to bumetanide-sensitive Na+-K+- YNL270c ALP1 high-affinity permease for basic amino vacuolar Cl- cotransport protein acids YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YJL094c similarity to E. hirae Na+/H+-antiporter YOL020w SCM2 high-affinity tryptophan transport protein vacuolar NapA YGR191w HIP1 histidine permease YGR020c VMA7 H+-ATPase V1 domain 14K subunit, YDR456w similarity to Na+/H+ antiporters YNL268w LYP1 lysine-specific high-affinity permease vacuolar YPR138c MEP3 strong similarity to ammonium transport YOR130c ARG11 member of the mitochondrial carrier YOR332w VMA4 H+-ATPase V1 domain 27K subunit, proteins family (MCF) vacuolar YHL016c DUR3 urea transport protein YHL036w MUP3 methionine permease YEL051w VMA8 H+-ATPase V1 domain 32K subunit, YOR348c PUT4 proline and γ-aminobutyrate permease vacuolar + anion transporters (Cl, SO4 ,PO4, etc) YKL174c similarity to choline transport protein YKL080w VMA5 H -ATPase V1 domain 42K subunit, YLR348c dicarboxylate carrier protein Ctr1p vacuolar YML123c PHO84 high-affinity inorganic phosphate/H+ YNR056c similarity to choline transport protein YPR036w VMA13 H+-ATPase V1 domain 54K subunit, symporter Ctr1p vacuolar YBR294w SUL1 high-affinity sulphate transport protein YFL055w similarity to Gap1p and other amino-acid YBR127c VMA2 H+-ATPase V1 domain 60K subunit, YJL117w PHO86 inorganic phospate transporter permeases vacuolar YCR037c PHO87 member of the phosphate permease YDR160w similarity to lysine transport protein LYP1 YDL185w TFP1 H+-ATPase V1 domain 69K subunit, family YLL061w strong similarity to amino-acid transport vacuolar YJR077c MIR1 phosphate transport protein, protein Gap1p YGL008c PMA1 H+-transporting P-type ATPase mitochondrial (MCF) YDR046c (PAP1) strong similarity to amino-acid transport YPL036w PMA2 H+-transporting P-type ATPase 2 YBR235w similarity to bumetanide-sensitive Na+-K+- proteins YAL026c DRS2 membrane-spanning P-type amino- Cl- cotransport protein YBR132c strong similarity to amino-acid permeases phospholipids-ATPase YJL094c similarity to E. hirae Na+/H+-antiporter YPL274w strong similarity to amino-acid transport YDR270w CCC2 probable copper-transporting ATPase NapA proteins YHR026w PPA1 proteolipid protein of proton-transporting YNR013c similarity to membrane protein Pho87p ATPase and hypothetical protein YJL198w lipid transporters YEL031w SPF1 P-type ATPase YCR098c GIT1 similarity to phosphate transporter YDR040c ENA1 P-type ATPase involved in Na+ and Li+ proteins YBR041w FAT1 fatty-acid transporter efflux YPR003c similarity to sulphate transporter proteins YKL188c PAT1 long-chain-fatty-acid transporter YDR039c ENA2 P-type ATPase involved in Na+ efflux YER053c strong similarity to mitochondrial YPL147w PXA1 long-chain-fatty-acid transporter YDR038c ENA5 P-type ATPase involved in Na+ efflux phosphate carrier protein YKL174c similarity to choline transport protein YBR295w PCA1 P-type Cu2+-transporting ATPase YJL198w strong similarity to Pho87p Ctr1p YIL048w similarity to amino-phospholipids-ATPase YBR296c strong similarity to phosphate-repressible YNR056c similarity to choline transport protein Drs2p phosphate permease Ctr1p YER166w similarity to ATPase P. falciparum ATPase YLR092w SEL2 strong similarity to Sul1p YHR123w EPT1 sn-1,2-diacylglycerol ethanolamine- and 2 cholinephosphotransferase YMR162c similarity to ATPases sugar and carbohydrate transporters YDR093w similarity to P. falciparum ATPase 2 purine and pyrimidine transporters YPR021c similarity to human citrate transporter ABC transporters protein YMR056c AAC1 ADP/ATP carrier protein (MCF) YKL217w JEN1 carboxylic-acid transporter protein YBL030c AAC2 ADP/ATP carrier protein (MCF) YDR406w PDR15 ATP-binding cassette protein family YBR291c CTP1 citrate transport protein, mitochondrial YBR085w AAC3 ADP/ATP carrier protein (MCF) member (MCF) YBR192w RIM2 mitochondrial carrier protein (MCF) YLR188w MDL1 ATP-binding cassette transporter family YLR348c dicarboxylate carrier protein YER056c FCY2 purine-cytosine permease member YLR081w GAL2 galactose (and glucose) permease YER060w FCY21 purine-cytosine permease YPL270w MDL2 ATP-binding cassette transporter family YGR289c AGT1 general α-glucoside permease YOR222w similarity to ADP/ATP carrier proteins member YLL043w FPS1 glycerol channel protein YPL134c similarity to ADP/ATP carrier proteins YKL209c STE6 ATP-binding cassette transporter protein YNL318c HXT14 hexose transport protein YPR011c similarity to ADP/ATP carrier proteins and YGR281w YOR1 ATP-binding cassette transporter protein YJL214w HXT8 hexose transport protein Graves disease carrier protein required for oligomycin resistance YJL219w HXT9 hexose transport protein YOR071c similarity to allantoin or uracil transport YMR301c ATM1 ATP-binding cassette transporter protein, YFL011w HXT10 hexose transporter proteins mitochondrial YDL194w SNF3 high-affinity glucose transporter YOR192c similarity to allantoin or uracil transport YCR011c ADP1 ATP-dependent permease YEL069c HXT13 high-affinity hexose transporter proteins YDR135c YCF1 glutathione S-conjugate transporter, YMR011w HXT2 high-affinity hexose transporter YGR096w similarity to bovine Graves disease carrier vacuolar YDR343c HXT6 high-affinity hexose transporter protein YKL188c PAT1 long-chain-fatty-acid transporter YDR342c HXT7 high-affinity hexose transporter YHR002w similarity to bovine mitochondrial carrier YPL147w PXA1 long-chain-fatty-acid transporter YML123c PHO84 high-affinity inorganic phosphate/H+ protein/Grave’s disease carrier protein YDR011w SNQ2 multidrug resistance protein symporter YGL186c similarity to hypothetical protein YER060w YPL058c PDR12 multidrug resistance transporter YOL156w HXT11 low-affinity glucose transporter and weak similarity to FCY2 protein YOR153w PDR5 pleiotropic drug resistance protein YHR094c HXT1 low-affinity hexose transporter YBL042c strong similarity to allantoin and uracil YOL075c similarity to A. gambiae ATP-binding- YDR345c HXT3 low-affinity hexose transporter transport proteins cassette protein YDR497c ITR1 major myo-inositol permease YER060w-a FCY22 strong similarity to Fcy2p YER036c similarity to members of the ABC YBR298c MAL31 maltose permease YBR021w FUR4 uracil permease transporter family YDL198c YHM1 member of the mitochondrial carrier YLL015w similarity to metal resistance proteins family (MCF) allantoin and allantoate transporters YHL035c similarity to multidrug resistance proteins YHR092c HXT4 moderate- to low-affinity glucose YKR103w similarity to multidrug resistance proteins transporter YJR152w DAL5 allantoate permease YKR104w similarity to multidrug resistance proteins YOL103w ITR2 myo-inositol transport protein YIR028w DAL4 allantoin permease YLL048c similarity to rat organic anion transporter YBR241c similarity to glucose transport proteins YIL166c similarity to allantoate permease Dal5p YIL013c PDR11 similarity to Snq2p and other ATP- YGL104c similarity to glucose transport proteins YCR028c FEN2 similarity to allantoate permease dependent permeases YDR387c similarity to Itr1p and Itr2p transporter YOR328w PDR10 strong similarity to ABC transporter YFR045w similarity to mitochondrial citrate transport YGR260w similarity to allantoate transport protein proteins proteins YLR004c similarity to allantoate transport protein YOR011w strong similarity to ATP-dependent permeases

52 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YDR091c strong similarity to human RNase L YCL069w strong similarity to drug resistance protein YOR130c ARG11 member of the mitochondrial carrier inhibitor and to M. jannaschii ABC SGE1 family (MCF) transporter YER087c-a SEB1 strong similarity to mammalian Sec61β YDL198c YHM1 member of the mitochondrial carrier YNR070w strong similarity to Snq2p subunit family (MCF) YKR067w strong similarity to Sct1p YNL064c YDJ1 mitochondrial and ER import protein drug transporters YBL011w SCT1 suppresses a choline-transport mutant YBR192w RIM2 mitochondrial carrier protein (MCF) YBL089w weak similarity to A. thaliana aminoacid YPR058w YMC1 mitochondrial carrier protein (MCF) YML116w ATR1 aminotriazole and 4-nitroquinoline permease AAP3 YBR104w YMC2 mitochondrial carrier protein (MCF) resistance protein YIL088c weak similarity to A. thaliana aminoacid YML062c MFT1 mitochondrial fusion target protein YGR281w YOR1 ATP-binding cassette transporter protein permease AAP4 YNR017w MAS6 mitochondrial inner membrane import required for oligomycin resistance YJR001w weak similarity to A. thaliana aminoacid translocase subunit YGR197c SNG1 involved in nitroguanidine resistance permease AAP4 YJL143w TIM17 mitochondrial inner membrane import YEL065w probably multidrug resistance protein YER119c weak similarity to E. herbicola tyrosine translocase subunit YMR123w PKR1 resistance against Pichia farinosa killer permease YIL022w TIM44 mitochondrial inner membrane import toxin (SMK toxin) when expressed by a YKL221w weak similarity to human X-linked PEST- translocase subunit multicopy plasmid containing transporter YNL131w TOM22 mitochondrial outer membrane import YMR088c similarity multidrug resistance proteins YEL064c weak similarity to members of the major receptor subunit YDR119w similarity to B. subtilis tetracyclin facilitator superfamily YGR082w TOM20 mitochondrial outer membrane import resistance YJR106w weak similarity to Na+/H+ antiporter receptor subunit, 20K YBR293w similarity to multidrug resistance proteins YDL206w weak similarity to transporter proteins YMR060c TOM37 mitochondrial outer membrane import YGR138c similarity to multidrug resistance proteins YKL146w weak similarity to transporter proteins receptor subunit, 37K YHR048w similarity to multidrug resistance proteins YMR203w TOM40 mitochondrial outer membrane import YPR156c similarity to multidrug resistance proteins receptor subunit, 40K YNL065w similarity to resistance proteins YOR045w TOM6 mitochondrial outer membrane import YIL013c PDR11 similarity to Snq2p and other ATP- Intracellular transport receptor subunit, 6K dependent permeases YNL070w TOM7 mitochondrial outer membrane import YMR279c strong similarity to aminotriazole nuclear transport receptor subunit, 7K resistance protein YNL055c POR1 mitochondrial outer membrane porin YGR224w strong similarity to drug resistance protein YIL075c SEN3 26S proteasome regulatory subunit YNL121c TOM70 mitochondrial outer membrane SGE1 YOR048c RAT1 5’-3’ exoribonuclease specialized import receptor YBR052c strong similarity to S. pombe brefeldin A YGL097w SRM1 GDP/GTP exchange factor for YAR035w YAT1 outer carnitine acetyltransferase, resistance protein obr1 Gsp1p/Gsp2p mitochondrial YAL067c SEO1 suppressor of sulphoxyde ethionine YOR185c GSP2 GTP-binding protein YJR077c MIR1 phosphate transport protein, resistance YLR293c GSP1 GTP-binding protein of the RAS mitochondrial (MCF) superfamily YBR091c MRS5 regulator of mitochondrial intron splicing other transport-facilitators YAL005c SSA1 heat-shock protein of HSP70 family YPL134c similarity to ADP/ATP carrier proteins YOR160w MTR10 involved in mRNA transport YER024w similarity to carnitine O-acetyltransferase YFL028c CAF16 ATP-binding cassette transporter protein YJL050w MTR4 involved in nucleocytoplasmic transport of Yat1p family member mRNA YPR021c similarity to human citrate transporter YER019c-a SEB2 ER protein-translocation complex subunit YBR017c KAP104 karyopherin protein YLR378c SEC61 ER protein-translocation complex subunit YNL189w SRP1 karyopherin-α or importin YER053c strong similarity to mitochondrial YPL094c SEC62 ER protein-translocation complex subunit YLR347c KAP95 karyopherin-β phosphate carrier protein YOR254c SEC63 ER protein-translocation complex subunit YKL186c MTR2 mRNA transport protein YLR034c strong similarity to SMF2 protein YBR171w SEC66 ER protein-translocation complex subunit YPL124w NIP29 nuclear import protein YHR117w TOM71 strong similarity to Tom70p/Mas70p YLR292c SEC72 ER protein-translocation complex subunit YPL174c NIP80 nuclear import protein YHR050w SMF2 suppressor of mitochondrial matrix YDR086c SSS1 ER protein-translocation complex subunit YMR129w POM152 nuclear pore membrane glycoprotein mutant YIL134w FLX1 FAD carrier protein, mitochondrial (MCF) YFR002w NIC96 nuclear pore protein YIL114c POR2 voltage dependent anion channel YCR023c member of major facilitator superfamily YJL041w NSP1 nuclear pore protein (YVDAC2) multidrug-resistance protein family 2 YOR098c NUP1 nuclear pore protein YKL039w PTM1 member of the major facilitator YKL068w NUP100 nuclear pore protein vesicular transport (Golgi network, etc.) superfamily YMR047c NUP116 nuclear pore protein YPR058w YMC1 mitochondrial carrier protein (MCF) YKL057c NUP120 nuclear pore protein YBR164c ARL1 ADP-ribosylation factor YNR017w MAS6 mitochondrial inner membrane import YKR082w NUP133 nuclear pore protein YOR094w ARF3 ADP-ribosylation factor 3 translocase subunit YGL092w NUP145 nuclear pore protein YGL167c PMR1 Ca2+-transporting P-type ATPase YJL143w TIM17 mitochondrial inner membrane import YER105c NUP157 nuclear pore protein YGR167w CLC1 clathrin light chain translocase subunit YIL115c NUP159 nuclear pore protein YOL062c APM4 clathrin-associate protein YAP54 YIL022w TIM44 mitochondrial inner membrane import YBL079w NUP170 nuclear pore protein YPL259c APM1 clathrin-associated protein translocase subunit YML103c NUP188 nuclear pore protein YBR288c APM3 clathrin-associated protein complex, YNL131w TOM22 mitochondrial outer membrane import YLR335w NUP2 nuclear pore protein medium subunit receptor subunit YDR192c NUP42 nuclear pore protein YPL010w RET3 coatomer complex ζ subunit YGR082w TOM20 mitochondrial outer membrane import YGL172w NUP49 nuclear pore protein YDL145c RET1 coatomer complex α subunit of secretory receptor subunit, 20K YGR119c NUP57 nuclear pore protein pathway vesicles YMR060c TOM37 mitochondrial outer membrane import YJL061w NUP82 nuclear pore protein YGL137w SEC27 coatomer complex β‘ subunit (β‘-cop) of receptor subunit, 37K YDL116w NUP84 nuclear pore protein secretory pathway vesicles YMR203w TOM40 mitochondrial outer membrane import YJR042w NUP85 nuclear pore protein YDR238c SEC26 coatomer complex β subunit of secretory receptor subunit, 40K YGL100w SEH1 nuclear pore protein pathway vesicles YOR045w TOM6 mitochondrial outer membrane import YBR170c NPL4 nuclear protein localization factor and ER YFR051c RET2 coatomer complex δ subunit receptor subunit, 6K translocation component YNL287w SEC21 coatomer complex γ subunit (γ-COP) of YNL070w TOM7 mitochondrial outer membrane import YER009w NTF2 nuclear transport factor secretory pathway vesicles receptor subunit, 7K YDR432w NPL3 nucleolar protein YDR170c SEC7 component of non-clathrin vesicle coat YNL055c POR1 mitochondrial outer membrane porin YDR002w YRB1 ran-specific GTPase-activating protein YPR181c SEC23 component of the COPII coat of ER-Golgi YNL121c TOM70 mitochondrial outer membrane YER107c GLE2 required for nuclear pore complex vesicles specialized import receptor structure and function YDL195w SEC31 component of the COPII coat of ER-Golgi YAR035w YAT1 outer carnitine acetyltransferase, YIR011c STS1 required for transport of Rna15p from the vesicles mitochondrial cytoplasm to the nucleus YGL200c EMP24 component of the COPII-coated vesicles, YKR093w PTR2 peptide transporter YDL207w GLE1 RNA export mediator 24K YIL120w similarity to antibiotic resistance proteins YIL063c YRB2 similarity to Yrp1p and Nup2p YML012w ERV25 component of the COPII-coated vesicles, YIL121w similarity to antibiotic resistance proteins YLR119w SRN2 suppressor of rna1-1 mutation 25K YCL038c similarity to bacterial membrane YFL049w weak similarity to Npl6p YMR017w DBI9 Dbf2p interacting protein transporter YKR054c DYN1 dynein heavy chain, cytosolic YBR043c similarity to benomyl/methotrexate mitochondrial transport YLR083c EMP70 endosomal protein resistance protein YBL040c ERD2 ER lumen protein-retaining receptor YHL040c similarity to C. carbonum toxin pump YMR056c AAC1 ADP/ATP carrier protein (MCF) YJR031c GEA1 GDP/GTP exchange factor for ARF YHL047c similarity to C. carbonum toxin pump YBL030c AAC2 ADP/ATP carrier protein (MCF) YEL022w GEA2 GDP/GTP exchange factor for ARF YER024w similarity to carnitine O-acetyltransferase YBR085w AAC3 ADP/ATP carrier protein (MCF) YNR026c SEC12 GDP/GTP exchange factor for Sar1p Yat1p YMR301c ATM1 ATP-binding cassette transporter protein, YPR017c DSS4 GDP/GTP exchange factor for Sec4p YOR291w similarity to cation translocating ATPases mitochondrial YDL192w ARF1 GTP-binding protein of the ARF family YFL054c similarity to channel proteins YML042w CAT2 carnitine O-acetyltransferase YDL137w ARF2 GTP-binding protein of the ARF family YBR180w similarity to drug resistance proteins YBR291c CTP1 citrate transport protein, mitochondrial YPL218w SAR1 GTP-binding protein of the ARF family YIL006w similarity to Flx1p (MCF) YFL038c YPT1 GTP-binding protein of the RAB family YOR306c similarity to human X-linked PEST- YOR316c COT1 cobalt accumulation protein YER031c YPT31 GTP-binding protein of the RAB family containing transporter YOR037w CYC2 cytochrome c mitochondrial import factor YLR262c YPT6 GTP-binding protein of the RAB family YIL056w similarity to hypothetical protein YER064c YLR348c dicarboxylate carrier protein YML001w YPT7 GTP-binding protein of the RAB family YNL003c PET8 similarity to mitochondrial rat YKL016c ATP7 F1F0-ATPase complex, F0 D subunit YFL005w SEC4 GTP-binding protein of the RAS tricarboxylate transport protein YBL099w ATP1 F1F0-ATPase complex, F1 α subunit superfamily YOL119c similarity to monocarboxylate transporter YJR121w ATP2 F1F0-ATPase complex, F1 β subunit YLL024c SSA2 heat-shock protein of HSP70 family, proteins YDL004w ATP16 F1F0-ATPase complex, F1 δ subunit cytosolic YGR065c similarity to P. putida phthalate transporter YPL078c ATP4 F1F0-ATPase complex, F1 δ subunit YLR268w SEC22 high copy suppressor of ypt1 null YOL163w similarity to P. putida phthalate transporter YPL271w ATP15 F1F0-ATPase complex, F1 ε subunit mutation YEL006w similarity to peroxisomal membrane and YBR039w ATP3 F1F0-ATPase complex, F1 γ subunit YDR189w SLY1 hydrophilic suppressor of ypt1 and mitochondrial carrier proteins YDR298c ATP5 F1F0-ATPase complex, OSCP subunit member of the Sec1p family YJR124c similarity to Staphylococcus multidrug YLR295c ATP14 F1F0-ATPase complex, subunit h YDL058w USO1 intracellular protein transport protein resistance protein YIL134w FLX1 FAD carrier protein, mitochondrial (MCF) YPL145c KES1 involved in ergosterol biosynthesis YNL125c similarity to YKL221w and human X-linked YOR232w MGE1 heat-shock protein - chaperone YKR068c BET3 involved in targeting and fusion of ER to PEST-containing transporter YLL024c SSA2 heat-shock protein of HSP70 family, Golgi transport vesicles YBR008c strong similarity to benomyl/methotrexate cytosolic YMR183c SSO2 involved in vesicle transport from Golgi to resistance protein YGR028w MSP1 intra-mitochondrial sorting protein plasma membrane YNL064c YDJ1 mitochondrial and ER import protein

NATURE | VOL 387 | SUPP | 29 MAY 1997 53 gazetteer

YJL004c SYS1 multicopy suppressor of ypt6 extracellular transport YNL270c ALP1 high-affinity permease for basic amino YPL085w SEC16 multidomain vesicle coat protein acids YOR326w MYO2 myosin heavy chain YJL085w EXO70 70K exocyst component protein YJL129c TRK1 high-affinity potassium transport protein YFL025c BST1 negative regulator of COPII vesicle YDR129c SAC6 actin filament bundling protein, fimbrin YBR294w SUL1 high-affinity sulphate transport protein formation YKL209c STE6 ATP-binding cassette transporter protein YOL020w SCM2 high-affinity tryptophan transport protein YMR079w SEC14 phosphatidylinositol/phosphatidylcholine YDL226c GCS1 cell proliferation zinc-finger protein YGR191w HIP1 histidine permease transfer protein YER136w GDI1 GDP dissociation inhibitor YMR319c FET4 low-affinity Fe(II) iron transport protein YCR067c SED4 protein of the endoplasmic reticulum YLL043w FPS1 glycerol channel protein YOL156w HXT11 low-affinity glucose transporter YIL004c BET1 protein transport protein YJL044c GYP6 GTPase-activating protein YHR094c HXT1 low-affinity hexose transporter YLR208w SEC13 protein transport protein YLR262c YPT6 GTP-binding protein of the RAB family YDR345c HXT3 low-affinity hexose transporter YNL272c SEC2 protein transport protein YJL205c-a NCE1 involved in non-classical protein export YNL268w LYP1 lysine-specific high-affinity permease YGR009c SEC9 protein transport protein pathway YDR497c ITR1 major myo-inositol permease YGL145w TIP20 required for ER to Golgi transport YPR149w NCE2 involved in non-classical protein export YBR298c MAL31 maltose permease YDR498c SEC20 secretory pathway protein pathway YOL122c SMF1 manganese transporter YBR097w VPS15 ser/thr protein kinase YNL036w NCE3 involved in non-classical protein export YKR050w TRK2 moderate-affinity potassium transport YBR264c similarity to GTP-binding proteins pathway protein YKL196c similarity to Sec22p YOR326w MYO2 myosin heavy chain YHR092c HXT4 moderate to low-affinity glucose YJL193w similarity to Sly41p YJL093c TOK1 outward-rectifier potassium channel transporter YGL210w YPT32 small GTP-binding protein YMR308c PSE1 protein secretion enhancer YOL103w ITR2 myo-inositol transport protein YKL006c-a SFT1 SNARE-like protein YDR164c SEC1 protein transport protein YLR240w VPS34 phosphatidylinositol 3-kinase YPL051w strong similarity to ADP-ribosylation YNL272c SEC2 protein transport protein YOR348c PUT4 proline and γ-aminobutyrate permease factors YIL068c SEC6 protein transport protein YER056c FCY2 purine-cytosine permease YDR107c strong similarity to EMP70 protein YPR055w SEC8 protein transport protein YLR088w GAA1 required for attachment of GPI anchor YAL030w SNC1 strong similarity to synaptic vesicle- YGR009c SEC9 protein transport protein onto proteins associated membrane protein YKL212w SAC1 recessive suppressor of secretory defect YNL084c END3 required for endocytosis and cytoskeletal YOR327c SNC2 strong similarity to synaptobrevin YLR166c SEC10 required for exocytosis organization YER039c strong similarity to vanadate resistance YDR166c SEC5 required for exocytosis YJR090c GRR1 required for glucose repression and for protein Van2p YNR049c MSO1 secretion protein, multicopy suppressor of glucose and cation transport YLR026c SED5 syntaxin (T-SNARE) sec1 YCR009c RVS161 similarity to human amphiphysin and YOR075w UFE1 syntaxin (T-SNARE) of the ER YER008c SEC3 secretory pathway protein Rvs167p YPL232w SSO1 syntaxin-related protein YOR307c SLY41 secretory pathway protein YDR046c (PAP1) strong similarity to amino-acid transport YBL050w SEC17 transport vesicle fusion protein YBR162w-a YSY6 secretory pathway protein proteins YLR396c VPS33 vacuolar sorting protein YLR250w SSP120 secretory protein YHR096c HXT5 strong similarity to hexose transporters YML097c VPS9 vacuolar sorting protein YCR032w similarity to human CDC4L protein YIL170w HXT12 strong similarity to sugar transport YGL225w GOG5 vanadate-resistance protein YER006w similarity to P. polycephalum myosin- proteins YGL233w SEC15 vesicular traffic control protein related protein mlpA YJR158w HXT16 strong similarity to sugar transport YBR080c SEC18 vesicular-fusion protein, functional YGR131w strong similarity to Nce2p proteins homologue of NSF YNL325c suppressor of sac1 mutation YNR072w HXT17 sugar transport protein YLR093c weak similarity to synaptobrevin YPL232w SSO1 syntaxin-related protein YOR329c SCD5 suppressor of clathrin deficiency YLR078c BOS1 weak similarity to synaptobrevin YGL233w SEC15 vesicular traffic control protein YPR129w SCD6 suppressor of clathrin deficiency (V-SNARE) YBR080c SEC18 vesicular-fusion protein, functional YBR021w FUR4 uracil permease homologue of NSF YMR231w PEP5 vacuolar biogenesis protein peroxisomal transport YLR337w VRP1 verprolin cellular import YBR080c SEC18 vesicular-fusion protein, functional YML042w CAT2 carnitine O-acetyltransferase homologue of NSF YKL188c PAT1 long-chain-fatty-acid transporter YPL195w YKS4 α- or γ- adaptin, large subunit of the YJR040w GEF1 voltage-gated chloride channel protein YPL147w PXA1 long-chain-fatty-acid transporter clathrin-associated protein(AP) complex YMR243c ZRC1 zinc- and cadmium resistance protein YER015w FAA2 long-chain-fatty-acid-CoA ligase YBL037w APL3 α-adaptin, large subunit of the clathrin- YDR329c PAS3 peroxisomal assembly protein associated protein(AP) complex other intracellular-transport activities YJL210w PAS5 peroxisomal assembly protein YFL039c ACT1 actin YDR142c PAS7 peroxisomal import protein YDR129c SAC6 actin filament bundling protein, fimbrin YKR054c DYN1 dynein heavy chain, cytosolic YLR191w PAS20 peroxisomal protein involved in protein YDL029w ACT2 actin-like protein YER019c-a SEB2 ER protein-translocation complex subunit import YCL040w GLK1 aldohexose specific glucokinase YLR378c SEC61 ER protein-translocation complex subunit YDR244w PAS10 putative peroxisomal targeting signal YJR152w DAL5 allantoate permease YPL094c SEC62 ER protein-translocation complex subunit receptor YIR028w DAL4 allantoin permease YOR254c SEC63 ER protein-translocation complex subunit YBR068c BAP2 amino-acid permease YBR171w SEC66 ER protein-translocation complex subunit vacuolar transport YEL063c CAN1 amino-acid permease YLR292c SEC72 ER protein-translocation complex subunit YBR069c VAP1 amino-acid permease YDR086c SSS1 ER protein-translocation complex subunit YDL128w VCX1 Ca2+-transport (H+/Ca2+ exchange) protein, YGR121c MEP1 ammonia permease of high capacity and YCR075c ERS1 intracellular protein transport protein vacuolar moderate affinity YHL019c APM2 involved in clathrin-dependent transport YGL006w PMC1 Ca2+-transporting P-type ATPase YKL135c APL2 β-adaptin processes YDR135c YCF1 glutathione S-conjugate transporter, YGR261c YKS5 β-adaptin, large subunit of the clathrin- YJL034w KAR2 nuclear fusion protein vacuolar associated protein(AP) complex YBR170c NPL4 nuclear protein localization factor and ER YOR089c VPS21 GTP-binding protein YBR109c CMD1 calmodulin translocation component YER031c YPT31 GTP-binding protein of the RAB family YDL226c GCS1 cell proliferation zinc-finger protein YKR093w PTR2 peptide transporter YKR014c YPT52 GTP-binding protein of the RAB family YMR058w FET3 cell-surface ferroxidase YKL198c PTK1 polyamine transport enhancing protein YNL093w YPT53 GTP-binding protein of the RAB family YGL077c HNM1 choline permease YDR040c ENA1 P-type ATPase involved in Na+ and Li+ (RAS superfamily) YGL206c CHC1 clathrin heavy chain efflux YMR054w STV1 H+-ATPase V0 domain 102K subunit, YGR167w CLC1 clathrin light chain YER060w FCY21 purine-cytosine permease vacuolar YLR170c APS1 clathrin-associated protein (AP) complex, YNL183c NPR1 ser/thr protein kinase YHR039c-a VMA10 H+-ATPase V0 domain 13K subunit, small subunit AP19 YOR100c similarity to mitochondrial carrier protein vacuolar YJR058c APS2 clathrin-associated protein 17, small YMC1 YEL027w CUP5 H+-ATPase V0 domain 17K subunit, subunit YGL216w similarity to mouse kinesin-related protein vacuolar YJR005w YAP80 clathrin-associated protein complex, KIF3 YPL234c TFP3 H+-ATPase V0 domain 17K subunit, β subunit YPR009w similarity to sterol uptake protein Sut1p vacuolar YJL024c APS3 clathrin-associated protein(AP) complex, YHR123w EPT1 sn-1,2-diacylglycerol ethanolamine- and YLR447c VMA6 H+-ATPase V0 domain 36K subunit, small subunit cholinephosphotransferase vacuolar YPR124w CTR1 copper transport protein YER060w-a FCY22 strong similarity to Fcy2p YOR270c VPH1 H+-ATPase V0 domain 95K subunit, YHR175w CTR2 copper transport protein YER087c-a SEB1 strong similarity to mammalian Sec61β vacuolar YNL243w SLA2 cytoskeleton assembly control protein subunit YGR020c VMA7 H+-ATPase V1 domain 14K subunit, YLL001w DNM1 dynamin-related protein vacuolar YDL210w UGA4 GABA-specific high-affinity permease YOR332w VMA4 H+-ATPase V1 domain 27K subunit, YPR029c APL4 γ-adaptin, large subunit of the clathrin- vacuolar associated protein(AP) complex Cellular organization and YEL051w VMA8 H+-ATPase V1 domain 32K subunit, YLR081w GAL2 galactose (and glucose) permease vacuolar YNR026c SEC12 GDP/GTP exchange factor for Sar1p biogenesis YKL080w VMA5 H+-ATPase V1 domain 42K subunit, YKR039w GAP1 general amino-acid permease vacuolar YLL043w FPS1 glycerol channel protein organization and biogenesis of cell wall and YPR036w VMA13 H+-ATPase V1 domain 54K subunit, YOR089c VPS21 GTP-binding protein plasma membrane vacuolar YER031c YPT31 GTP-binding protein of the RAB family YBR127c VMA2 H+-ATPase V1 domain 60K subunit, YKR014c YPT52 GTP-binding protein of the RAB family YLR342w FKS1 1,3-—D-glucan synthase, catalytic subunit vacuolar YML001w YPT7 GTP-binding protein of the RAB family YGR032w GSC2 1,3-—D-glucan synthase, subunit YDL185w TFP1 H+-ATPase V1 domain 69K subunit, YNL093w YPT53 GTP-binding protein of the RAB family YOR362c PRE10 26S proteasome subunit C1 vacuolar (RAS superfamily) YJR004c SAG1 α-agglutinin YPL066w VPS28 involved in vacuolar traffic YNL318c HXT14 hexose transport protein YNR044w AGA1 α-agglutinin anchor subunit YMR004w MVP1 required for vacuolar protein sorting YJL214w HXT8 hexose transport protein YGL032c AGA2 α-agglutinin binding subunit YBR097w VPS15 ser/thr protein kinase YJL219w HXT9 hexose transport protein YDR077w SED1 abundant cell-surface glycoprotein YJL222w strong similarity to Pep1p YFL011w HXT10 hexose transporter YJL005w CYR1 adenylate cyclase YOR036w PEP12 syntaxin (T-SNARE) YDL194w SNF3 high-affinity glucose transporter YCL007c CWH36 affects the mannoprotein layer of the cell YNR006w VPS27 vacuolar protein sorting-associated YEL069c HXT13 high-affinity hexose transporter wall protein YMR011w HXT2 high-affinity hexose transporter YOR335c ALA1 alanyl-tRNA synthetase, cytosolic YGL095c VPS45 vacuolar protein sorting-associated YDR343c HXT6 high-affinity hexose transporter YPL061w ALD6 aldehyde dehydrogenase, cytosolic protein YDR342c HXT7 high-affinity hexose transporter YJR152w DAL5 allantoate permease YDR323c PEP7 vacuolar segregation protein YML123c PHO84 high-affinity inorganic phosphate/H+ YIR028w DAL4 allantoin permease YPL045w VPS16 vacuolar sorting protein symporter YBR068c BAP2 amino-acid permease YPR173c VPS4 vacuolar sorting protein YNL142w MEP2 high-affinity low capacity ammonia YEL063c CAN1 amino-acid permease YAL002w VPS8 vacuolar sorting protein permease YBR069c VAP1 amino-acid permease YML097c VPS9 vacuolar sorting protein YGR055w MUP1 high-affinity methionine permease

54 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YML116w ATR1 aminotriazole and 4-nitroquinoline YHR092c HXT4 moderate- to low-affinity glucose YMR138w CIN4 GTP-binding protein resistance protein transporter YOR156c NFI1 interacts with Cdc12p in 2-hybrid assay YGR121c MEP1 ammonia permease of high capacity and YGR014w MSB2 multicopy suppressor of a cdc24 bud YML104c MDM1 intermediate filament protein moderate affinity emergence defect YLL021w SPA2 involved in cell polarity YDR144c MKC7 aspartyl protease of the periplasmic YDR011w SNQ2 multidrug resistance protein YPL241c CIN2 involved in chromosome segregation space YOL103w ITR2 myo-inositol transport protein YDR085c AFR1 involved in morphogenesis of the mating YLR120c YAP3 aspergillopepsin YJL093c TOK1 outward-rectifier potassium channel projection YKL209c STE6 ATP-binding cassette transporter protein YKR093w PTR2 peptide transporter YEL061c CIN8 kinesin-related protein YGR281w YOR1 ATP-binding cassette transporter protein YFL026w STE2 pheromone α-factor receptor YPR141c KAR3 kinesin-related protein required for oligomycin resistance YKL178c STE3 pheromone a-factor receptor YBL063w KIP1 kinesin-related protein YCR011c ADP1 ATP-dependent permease YMR008c PLB1 phospholipase B (lysophospholipase) YPL155c KIP2 kinesin-related protein YER123w YCK3 casein kinase, isoform 3 YOR153w PDR5 pleiotropic drug resistance protein YKL079w SMY1 kinesin-related protein YCL027w FUS1 cell fusion protein YCR034w GNS1 probable 1,3-—glucan synthase subunit YBR172c SMY2 kinesin-related protein YMR058w FET3 cell-surface ferroxidase YOR348c PUT4 proline and γ-aminobutyrate permease YOR058c ASE1 microtubule-associated protein YKL096w CWP1 cell-wall mannoprotein YPL140c MKK2 protein kinase of the MAP kinase kinase YJL042w MHP1 microtubule-associated protein YKL096w-a CWP2 cell-wall mannoprotein (MEK) family YMR294w JNM1 mitosis protein, involved in nuclear YNL322c KRE1 cell-wall protein YGR009c SEC9 protein transport protein migration YAR050w FLO1 cell-wall protein involved in flocculation YER056c FCY2 purine-cytosine permease YBL034c STU1 mitotic spindle protein YNL192w CHS1 chitin synthase I YIL140w SRO4 required for axial pattern of budding YOR326w MYO2 myosin heavy chain YBR038w CHS2 chitin synthase II YCR089w FIG2 required for efficient mating YAL029c MYO4 myosin heavy chain, unconventional YBR023c CHS3 chitin synthase III YDR122w KIN1 ser/thr protein kinase (class V) isoform YGL077c HNM1 choline permease YLR096w KIN2 ser/thr protein kinase YMR109w MYO5 myosin I YOR010c TIR2 cold-shock induced protein YPL176c similarity to chinese hamster transferrin YKL129c MYO3 myosin type I YER011w TIR1 cold-shock induced protein of the Tir1p, receptor protein YHR023w MYO1 myosin-1 isoform (type II myosin) heavy Tip1p family YKR102w similarity to Flo1p chain YPR124w CTR1 copper transport protein YHL028w similarity to mucin and other ser-thr rich YCL029c BIK1 nuclear fusion protein YGR282c BGL2 endo-1,3-—glucanase of the cell wall proteins YOR122c PFY1 profilin YOR190w SPR1 exo-1,3-—glucanase YJR151c similarity to mucin proteins YDR164c SEC1 protein transport protein YDR261c EXG2 exo-1,3-—glucanase minor isoform YMR317w similarity to mucins, glucan 1,4-— YDR388w RVS167 reduced viability upon starvation protein YLR214w FRE1 ferric (and cupric) reductase glucosidase and exo-—sialidase YNL084c END3 required for endocytosis and cytoskeletal YKL220c FRE2 ferric (and cupric) reductase YCR098c GIT1 similarity to phosphate transporter organization YDL210w UGA4 GABA-specific high-affinity permease proteins YBR130c SHE3 required for mother cell-specific YLR081w GAL2 galactose (and glucose) permease YIL013c PDR11 similarity to Snq2p and other ATP- expression of HO YLL016w SDC25 GDP/GTP exchange factor dependent permeases YGR078c PAC10 required in the absence of Cin8p YLR310c CDC25 GDP/GTP exchange factor for Ras1p and YIL063c YRB2 similarity to Yrp1p and Nup2p YDR488c PAC11 required in the absence of Cin8p Ras2p YNL126w SPC98 spindle pole body component YER007w PAC2 required in the absence of Cin8p YCR038c BUD5 GDP/GTP exchange factor for YHR139c SPS100 sporulation-specific wall maturation YJR076c CDC11 septin Rsr1p/Bud1p protein YHR107c CDC12 septin YKR039w GAP1 general amino-acid permease YOR328w PDR10 strong similarity to ABC transporter YDR218c SPR28 septin-related sporulation protein YMR307w GAS1 glycophospholipid-anchored surface proteins YNL059c similarity to actin glycoprotein YDR046c (PAP1) strong similarity to amino-acid transport YLR085c similarity to actin and actin-related YOL081w IRA2 GTPase-activating protein for RAS proteins proteins proteins YDR134c strong similarity to Flo1p YLR429w similarity to actin binding protein coronin YOR101w RAS1 GTP-binding protein YAL063c FLO9 strong similarity to Flo1p YPR034w similarity to actins YNL098c RAS2 GTP-binding protein YLR343w strong similarity to Gas1p and C. albicans YGL003c similarity to C. elegans CDC20 protein YHR005c GPA1 GTP-binding protein α subunit of the pH responsive protein and human p55CDC pheromone pathway YOL030w strong similarity to glycoprotein GAS1 YCR009c RVS161 similarity to human amphiphysin and YOR212w STE4 GTP-binding protein β subunit of the YHR096c HXT5 strong similarity to hexose transporters Rvs167p pheromone pathway YDR536w STL1 strong similarity to members of the sugar YER018c similarity to lamins YJR086w STE18 GTP-binding protein γ subunit of the permease family YOR367w similarity to mammalian smooth muscle pheromone pathway YIL170w HXT12 strong similarity to sugar transport protein SM22 YLR229c CDC42 GTP-binding protein of RAS superfamily proteins YIL149c similarity to Mlp1p and myosin heavy YCR024c-a PMP1 H+-ATPase subunit, plasma membrane YJR158w HXT16 strong similarity to sugar transport chains YEL017c-a PMP2 H+-ATPase subunit, plasma membrane proteins YGL216w similarity to mouse kinesin-related protein YGL008c PMA1 H+-transporting P-type ATPase YNR072w HXT17 sugar transport protein KIF3 YPL036w PMA2 H+-transporting P-type ATPase 2 YPL232w SSO1 syntaxin-related protein YKL179c similarity to Nuf1p YDR420w HKR1 Hansenula MrakII k9 killer toxin-resistance YBR067c TIP1 temp.shock induced protein of the YJR134c similarity to paramyosin, myosin protein Srp1p/Tip1p family YPL105c similarity to Smy2p YLL024c SSA2 heat-shock protein of HSP70 family, YJR007w SUI2 translation initiation factor eIF2, α subunit YDR356w NUF1 spindle pole body component cytosolic YIL147c SLN1 two-component signal transducer YNL126w SPC98 spindle pole body component YNL318c HXT14 hexose transport protein YER125w RSP5 ubiquitin-protein ligase YOL069w NUF2 spindle pole body protein YJL214w HXT8 hexose transport protein YBR021w FUR4 uracil permease YGR059w SPR3 sporulation-specific septin YJL219w HXT9 hexose transport protein YHL016c DUR3 urea transport protein YEL071w strong similarity to Aip2p YFL011w HXT10 hexose transporter YGL233w SEC15 vesicular traffic control protein YOR134w BAG7 structural homologue of Sac7p YDL194w SNF3 high-affinity glucose transporter YJR040w GEF1 voltage-gated chloride channel protein YAL047c SPI6 Stu2p Interactant YEL069c HXT13 high-affinity hexose transporter YMR243c ZRC1 zinc- and cadmium resistance protein YKL022c CDC16 subunit of anaphase-promoting complex YMR011w HXT2 high-affinity hexose transporter (cyclosome) YDR343c HXT6 high-affinity hexose transporter organization and biogenesis of cytoskeleton YHR166c CDC23 subunit of anaphase-promoting complex YDR342c HXT7 high-affinity hexose transporter (cyclosome) YML123c PHO84 high-affinity inorganic phosphate/H+ YML085c TUB1 α-1 tubulin YBL084c CDC27 subunit of anaphase-promoting complex symporter YML124c TUB3 α-3 tubulin (cyclosome) YNL142w MEP2 high-affinity low-capacity ammonia YFL039c ACT1 actin YDR484w SAC2 suppressor of actin mutation permease YMR092c AIP1 actin cytoskeleton component YDR389w SAC7 suppressor of actin mutation YGR055w MUP1 high-affinity methionine permease YDR129c SAC6 actin filament bundling protein, fimbrin YNL079c TPM1 tropomyosin 1 YNL270c ALP1 high-affinity permease for basic amino YDL178w AIP2 actin interacting protein 2 YIL138c TPM2 tropomyosin 2 acids YJR065c ACT4 actin-related protein YPL045w VPS16 vacuolar sorting protein YJL129c TRK1 high-affinity potassium transport protein YCR088w ABP1 actin-binding protein YLR337w VRP1 verprolin YBR294w SUL1 high-affinity sulphate transport protein YDL029w ACT2 actin-like protein YOL020w SCM2 high-affinity tryptophan transport protein YDR106w ARP10 actin-related protein organization and biogenesis of endoplasmic YGR191w HIP1 histidine permease YNL059c ARP5 actin-related protein reticulum and Golgi YBR140c IRA1 inhibitory regulator protein of the RAS- YLR085c ARP6 actin-related protein cyclic AMP pathway YOR141c ARP8 actin-related protein YML075c HMG1 3-hydroxy-3-methylglutaryl-CoA reductase YNL291c MID1 involved in Ca2+ influx during mating YNR033w ARP9 actin-related protein 1 YHL019c APM2 involved in clathrin-dependent transport YNL138w SRV2 adenylate cyclase-associated protein, 70K YLR450w HMG2 3-hydroxy-3-methylglutaryl-CoA reductase processes YAL020c ATS1 α-tubulin suppressor 2 YLR452c SST2 involved in desensitization to α-factor YER016w BIM1 binding to microtubules YJR131w MNS1 α-1,2-mannosidase pheromone YFL037w TUB2 β-tubulin YDR483w KRE2 α-1,2-mannosyltransferase YCL051w LRE1 involved in laminarinase resistance YOR265w RBL2 β-tubulin binding protein YER001w MNN1 α-1,3-mannosyltransferase YER118c SSU81 involved in the HOG1 high-osmolarity YBR200w BEM1 bud emergence mediator YGL038c OCH1 α-1,6-mannosyltransferase signal transduction pathway YLR319c BUD6 bud site selection protein YGL027c CWH41 β-1,6-glucan assembly protein YMR183c SSO2 involved in vesicle transport from Golgi to YNL271c BNI1 budding protein YBR110w ALG1 β-mannosyltransferase plasma membrane YBR109c CMD1 calmodulin YMR015c ERG5 C-22 sterol desaturase YLR155c ASP3A L-asparaginase II YCR002c CDC10 cell division control protein YGR060w ERG25 C-4 sterol methyl oxidase YLR157c ASP3B L-asparaginase II YGL116w CDC20 cell division control protein YLR056w ERG3 C-5 sterol desaturase YLR158c ASP3C L-asparaginase II YLR314c CDC3 cell division control protein YMR202w ERG2 C-8 sterol isomerase YLR160c ASP3D L-asparaginase II YFL009w CDC4 cell division control protein YGL167c PMR1 Ca2+-transporting P-type ATPase YMR319c FET4 low-affinity Fe(II) iron transport protein YHR129c ACT5 centractin YBR036c CSG2 calcium dependent regulatory protein YOL156w HXT11 low-affinity glucose transporter YLR175w CBF5 centromere/microtubule binding protein YGL203c KEX1 carboxypeptidase (YSC-α) YHR094c HXT1 low-affinity hexose transporter YOR349w CIN1 chromosome segregation protein YPR113w PIS1 CDP diacylglycerol-inositol YDR345c HXT3 low-affinity hexose transporter YLL050c COF1 cofilin, actin binding and severing protein 3-phosphatidyltransferase YNL268w LYP1 lysine-specific high-affinity permease YBL007c SLA1 cytoskeleton assembly control protein YER026c CHO1 CDP-diacylglycerol serine YDR497c ITR1 major myo-inositol permease YNL243w SLA2 cytoskeleton assembly control protein O-phosphatidyltransferase YBR298c MAL31 maltose permease YLL001w DNM1 dynamin-related protein YBR029c CDS1 CDP-diacylglycerol synthase YOL122c SMF1 manganese transporter YKR054c DYN1 dynein heavy chain, cytosolic YKL073w LHS1 chaperone of the ER lumen YIL047c SYG1 member of the major facilitator YDR424c DYN2 dynein light chain 1, cytosolic YGR202c PCT1 cholinephosphate cytidylyltransferase superfamily YKL007w CAP1 F-actin capping protein, α subunit YOL062c APM4 clathrin-associate protein YAP54 YKR050w TRK2 moderate-affinity potassium transport YIL034c CAP2 F-actin capping protein, β subunit YPL259c APM1 clathrin-associated protein protein YLR212c TUB4 γ tubulin

NATURE | VOL 387 | SUPP | 29 MAY 1997 55 gazetteer

YDL195w SEC31 component of the COPII coat of ER-Golgi YDR245w MNN10 similarity to S. pombe YGR274c TAF145 TFIID subunit (TBP-associated factor), vesicles galactosyltransferase 145K YGL200c EMP24 component of the COPII-coated vesicles, YMR214w SCJ1 similarity to to E. coli dnaJ YGR187c HGH1 weak similarity to human Hmg1p and 24K YHR123w EPT1 sn-1,2-diacylglycerol ethanolamine- and Hmg2p YML012w ERV25 component of the COPII-coated vesicles, cholinephosphotransferase YGR285c ZUO1 zuotin (Z-DNA binding protein) 25K YKL006c-a SFT1 SNARE-like protein YHR007c ERG11 cytochrome P450 lanosterol YGR175c ERG1 squalene monooxygenase mitochondrial organization and biogenesis 14a-demethylase YGL055w OLE1 stearoyl-CoA desaturase YNL130c CPT1 diacylglycerol cholinephosphotransferase YLR080w strong similarity to Emp47p YHR037w PUT2 1-pyrroline-5-carboxylate dehydrogenase YMR013c SEC59 dolichol kinase YER087c-a SEB1 strong similarity to mammalian Sec61β YNL104c LEU4 2-isopropylmalalate synthase YPL227c ALG5 dolichol-P-glucose synthetase subunit YMR282c AEP2 2’-O-ribosyl phosphate transferase YPR183w DPM1 dolichyl-phosphate YOR099w KTR1 strong similarity to mannosyltransferases YIL125w KGD1 2-oxoglutarate dehydrogenase complex β-D-mannosyltransferase YGL226c-a OST5 subunit of N-oligosaccharyltransferase, E1 component YJR143c PMT4 dolichyl-phosphate-mannose-protein ζ subunit YDR148c KGD2 2-oxoglutarate dehydrogenase complex O-mannosyl transferase YDR297w SUR2 suppressor of rvs161 and rvs167 E2 component YDL212w SHR3 endoplasmic reticulum membrane protein mutations YOL096c COQ3 3,4-dihydroxy-5-hexaprenylbenzoate YNL238w KEX2 endoproteinase of late Golgi YBL102w SFT2 suppressor of sed5 ts mutants methyltransferase compartment YLR026c SED5 syntaxin (T-SNARE) YMR287c MSU1 3’-5’ exonuclease for RNA 3’ ss-tail, YBL040c ERD2 ER lumen protein-retaining receptor YOR075w UFE1 syntaxin (T-SNARE) of the ER mitochondrial YLR378c SEC61 ER protein-translocation complex subunit YOR219c STE13 type IV dipeptidyl aminopeptidase YDR232w HEM1 5-aminolevulinate synthase YPL094c SEC62 ER protein-translocation complex subunit YMR022w QRI8 ubiquitin-conjugating enzyme YML009c MRPL39 60S ribosomal protein, mitochondrial YOR254c SEC63 ER protein-translocation complex subunit YER100w UBC6 ubiquitin-conjugating enzyme YMR108w ILV2 acetolactate synthase YBR171w SEC66 ER protein-translocation complex subunit YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate YCL009c ILV6 acetolactate synthase, regulatory subunit YLR292c SEC72 ER protein-translocation complex subunit transferase YAL054c ACS1 acetyl-CoA synthetase YDR086c SSS1 ER protein-translocation complex subunit YGR105w VMA21 vacuolar ATPase assembly integral YER069w ARG5,6 acetylglutamate kinase and YDR331w GPI8 essential for GPI-anchor attachment membrane protein acetylglutamyl-phosphate reductase YHR190w ERG9 farnesyl-diphosphate farnesyltransferase YBL017c PEP1 vacuolar protein sorting/targeting protein YOL140w ARG8 acetylornithine aminotransferase YDR519w FKB2 FK506/rapamycin-binding protein of the YGL225w GOG5 vanadate-resistance protein YLR304c ACO1 aconitate hydratase ER YDR234w LYS4 aconitate hydratase YJR031c GEA1 GDP/GTP exchange factor for ARF organization and biogenesis of chromosome YER170w ADK2 adenylate kinase, mitochondrial YEL022w GEA2 GDP/GTP exchange factor for ARF structure YMR056c AAC1 ADP/ATP carrier protein (MCF) YNR026c SEC12 GDP/GTP exchange factor for Sar1p YBL030c AAC2 ADP/ATP carrier protein (MCF) YPR159w KRE6 glucan synthase subunit YJL081c ACT3 actin-related protein YBR085w AAC3 ADP/ATP carrier protein (MCF) YGR143w SKN1 glucan synthase subunit YDL220c CDC13 cell division control protein YMR083w ADH3 alcohol dehydrogenase III YOR067c ALG8 glucosyltransferase YBR195c MSI1 chromatin assembly complex, subunit YER073w aldehyde dehydrogenase (NAD+) YFL048c EMP47 Golgi membrane protein p50 YMR170c ALD5 aldehyde dehydrogenase 2 (NAD+), YDL192w ARF1 GTP-binding protein of the ARF family YML102w CAC2 chromatin assembly complex, subunit mitochondrial YPL218w SAR1 GTP-binding protein of the ARF family p60 YER086w ILV1 anabolic serine and threonine YFL038c YPT1 GTP-binding protein of the RAB family YPR018w RLF2 chromatin assembly complex, subunit dehydratase YLR262c YPT6 GTP-binding protein of the RAB family p90 YJL209w CBP1 apo-cytochrome b pre-mRNA processing YPR165w RHO1 GTP-binding protein of the RHO subfamily YGR218w CRM1 chromosome region maintenance protein protein of RAS-like proteins YNL216w RAP1 DNA-binding protein with repressor and YBR120c CBP6 apo-cytochrome b pre-mRNA processing YNL090w RHO2 GTP-binding protein of the RHO subfamily activator activity protein of RAS-like proteins YER159c NCB1 functional homologue of human NC2α YHL038c CBP2 apo-cytochrome b pre-mRNA processing YEL042w GDA1 guanosine diphosphatase YMR072w ABF2 high-mobility group protein protein 2 YDR189w SLY1 hydrophilic suppressor of ypt1 and YPL127c HHO1 histone H1 protein YHR091c MSR1 arginyl-tRNA synthetase, mitochondrial member of the Sec1p family YDR225w HTA1 histone H2A YCR024c asn-tRNA synthetase, mitochondrial YCR075c ERS1 intracellular protein transport protein YBL003c HTA2 histone H2A.2 YKL106w AAT1 aspartate transaminase, mitochondrial YDL058w USO1 intracellular protein transport protein YDR224c HTB1 histone H2B YPL104w MSD1 aspartate-tRNA ligase, mitochondrial YLR220w CCC1 involved in calcium regulation YBL002w HTB2 histone H2B.2 YGR008c STF2 ATPase stabilizing factor YBR201w DER1 involved in degradation proteins in the ER YBR010w HHT1 histone H3 YDL130w-a STF1 ATPase stabilizing factor, 10K YOR069w VPS5 involved in Golgi retention and vacuolar YNL031c HHT2 histone H3 YDR377w ATP17 ATPase synthase subunit f sorting YBR009c HHF1 histone H4 YMR301c ATM1 ATP-binding cassette transporter protein, YOR336w KRE5 killer toxin-resistance protein YNL030w HHF2 histone H4 mitochondrial YHR072w ERG7 lanosterol synthase YER161c SPT2 HMG-like chromatin protein YBL022c PIM1 ATP-dependent protease, mitochondrial YKR061w KTR2 mannosyltransferase YPL254w HFI1 interacts functionally with histone H2A YPL029w SUV3 ATP-dependent RNA helicase, YDL095w PMT1 mannosyltransferase YNR010w CSE2 interacts with centromeric element CDEII mitochondrial YAL023c PMT2 mannosyltransferase YGR099w TEL2 involved in controlling telomere length YER061c CEM1 β-keto-acyl-ACP synthase YOR321w PMT3 mannosyltransferase and position effect YHR208w TWT1 branched chain amino-acid YBL082c RHK1 mannosyltransferase YJR060w CBF1 kinetochore protein aminotransferase, mitochondrial YJL139c YUR1 mannosyltransferase YGR140w CBF2 kinetochore protein complex CBF3, 110K YBR084w MIS1 C1-tetrahydrofolate synthase, YKR001c VPS1 member of the dynamin family of subunit mitochondrial GTPases YMR094w CTF13 kinetochore protein complex CBF3, 58K YML042w CAT2 carnitine O-acetyltransferase YJR073c OPI3 methylene-fatty-acyl-phospholipid subunit YER026c CHO1 CDP-diacylglycerol serine synthase YMR168c CEP3 kinetochore protein complex CBF3, 71K O-phosphatidyltransferase YNL064c YDJ1 mitochondrial and ER import protein subunit YNR001c CIT1 citrate (si)-synthase, mitochondrial YPL085w SEC16 multidomain vesicle coat protein YDR328c SKP1 kinetochore protein complex CBF3, YPR001w CIT3 citrate (si)-synthase, mitochondrial YHR042w NCP1 NADPH-cytochrome P450 reductase subunit D YBR291c CTP1 citrate transport protein, mitochondrial YFL025c BST1 negative regulator of COPII vesicle YIL072w HOP1 meiosis-specific protein (MCF) formation YLR263w RED1 meiosis-specific protein YOR316c COT1 cobalt accumulation protein YJL034w KAR2 nuclear fusion protein YLR457c NBP1 Nap1p-binding protein YOR017w PET127 component of mitochondrial translation YJL002c OST1 oligosaccharyltransferase α subunit YDR162c NBP2 Nap1p-binding protein system YEL002c WBP1 oligosaccharyltransferase β subunit YBR089c-a NHP6B nonhistone chromosomal protein YPR155c NCA2 control of mitochondrial synthesis of YMR149w SWP1 oligosaccharyltransferase δ subunit YPR052c NHP6A nonhistone chromosomal protein related Atp6p and Atp8p YOR103c OST2 oligosaccharyltransferase ε subunit to mammalian HMG1 YKL011c CCE1 cruciform-cutting endonuclease, YOR085w OST3 oligosaccharyltransferase γ subunit YDR174w HMO1 nonhistone protein mitochondrial YGL022w STT3 oligosaccharyltransferase subunit YDL002c HMO2 nonhistone protein YML078w CPR3 cyclophilin (peptidylprolyl isomerase), YHR057c CYP2 peptidyl-prolyl cis-trans isomerase YKR048c NAP1 nucleosome assembly protein I mitochondrial YCR069w SCC3 peptidyl-prolyl cis-trans isomerase YCL011c GBP2 potential telomere-associated protein YDR197w CBS2 cytochrome b translational activator YDR304c CYP5 peptidyl-prolyl cis-trans isomerase D YGL238w CSE1 probable kinetochore protein protein (cyclophilin D) of the ER YGL194c RTL1 putative deacetylase YIL043c CBR1 cytochrome b5 reductase YGR157w CHO2 phosphatidylethanolamine YBR275c RIF1 Rap1p-interacting factor 1 YKL150w MCR1 cytochrome b5 reductase N-methyltransferase YKL089w MIF2 required for normal chromosome YKL141w SDH3 cytochrome b560 subunit of respiratory YGR170w PSD2 phosphatidylserine decarboxylase 2 segregation and spindle integrity complex II YDR518w EUG1 protein disulphide isomerase YJL074c SMC3 required for structural maintenance of YJR048w CYC1 cytochrome c isoform 1 YCL043c PDI1 protein disulphide-isomerase chromosomes YEL039c CYC7 cytochrome c isoform 2 YHR079c IRE1 protein kinase YLR086w similarity to chromosome condensation YOR037w CYC2 cytochrome c mitochondrial import factor YEL036c ANP1 protein of the endoplasmatic reticulum proteins YER058w PET117 cytochrome c oxidase assembly factor YCR067c SED4 protein of the endoplasmic reticulum YML069w POB3 similarity to HMG proteins YPL132w COX11 cytochrome c oxidase assembly protein YIL004c BET1 protein transport protein YOR053w similarity to protamines YML129c COX14 cytochrome c oxidase assembly protein YDR040c ENA1 P-type ATPase involved in Na+ and Li+ YNL206c similarity to structure-specific recognition YDR079w PET100 cytochrome c oxidase assembly protein efflux proteins YGL187c COX4 cytochrome c oxidase subunit IV YKL212w SAC1 recessive suppressor of secretory defect YDL208w NHP2 strong similarity to high mobility group YNL052w COX5A cytochrome c oxidase subunit V.A YLR088w GAA1 required for attachment of GPI anchor (HMG) family YIL111w COX5B cytochrome c oxidase subunit Vb onto proteins YEL026w strong similarity to high mobility group-like YHR051w COX6 cytochrome c oxidase subunit VI YPL050c MNN9 required for complex N-glycosylation protein Nhp2p YGL191w COX13 cytochrome c oxidase subunit VIa YCL001w RER1 required for correct localization of Sec12p YOL012c HTA3 strong similarity to histone H2A protein YLR038c COX12 cytochrome c oxidase subunit VIB YGL145w TIP20 required for ER to Golgi transport YKL049c CSE4 strong similarity to histone H3 YMR256c COX7 cytochrome c oxidase subunit VII YDR414c ERD1 required for retention of luminal ER YOR213c subunit of the RSC complex YDL067c COX9 cytochrome c oxidase subunit VIIA proteins YCR052w RSC6 subunit of the RSC complex YLR395c COX8 cytochrome c oxidase subunit VIII YMR004w MVP1 required for vacuolar protein sorting YFR037c RSC8 subunit of the RSC complex YKR066c CCP1 cytochrome c peroxidase YDR498c SEC20 secretory pathway protein YLR321c SFH1 subunit of the RSC complex YOR065w CYT1 cytochrome c1 YJR010c-a SPC1 signal peptidase 10.8K subunit YIL126w STH1 subunit of the RSC complex YER141w COX15 cytochrome oxidase assembly factor YML055w SPC2 signal peptidase 18K subunit YDR285w ZIP1 synaptonemal complex protein YER154w OXA1 cytochrome oxidase biogenesis protein YDR292c SRP101 signal recognition particle receptor, YLR233c EST1 telomere elongation protein YOR386w PHR1 deoxyribodipyrimidine photo-lyase α subunit YBL088c TEL1 telomere length control protein YLR348c dicarboxylate carrier protein YIR022w SEC11 signal sequence processing protein YPL128c TBF1 telomere TTAGGG repeat-binding factor 1 YFL018c LPD1 dihydrolipoamide dehydrogenase YAL058w CNE1 similarity to calnexin YNL071w LAT1 dihydrolipoamide S-acetyltransferase

56 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YJR016c ILV3 dihydroxy-acid dehydratase YNL131w TOM22 mitochondrial outer membrane import YBL038w MRPL16 ribosomal protein, mitochondrial YDL174c DLD1 D-lactate ferricytochrome c receptor subunit YMR193w MRPL24 ribosomal protein, mitochondrial oxidoreductase (D-LCR) YGR082w TOM20 mitochondrial outer membrane import YMR024w MRPL3 ribosomal protein, mitochondrial YML061c PIF1 DNA helicase involved in mitochondrial receptor subunit, 20K YMR286w MRPL33 ribosomal protein, mitochondrial DNA repair and telomere length YMR060c TOM37 mitochondrial outer membrane import YLR439w MRPL4 ribosomal protein, mitochondrial YHR120w MSH1 DNA mismatch repair protein, receptor subunit, 37K YHR147c MRPL6 ribosomal protein, mitochondrial mitochondrial YMR203w TOM40 mitochondrial outer membrane import YGR220c MRPL9 ribosomal protein, mitochondrial YOR330c MIP1 DNA-directed DNA polymerase γ, catalytic receptor subunit, 40K YDR337w MRPS28 ribosomal protein, mitochondrial subunit, mitochondrial YOR045w TOM6 mitochondrial outer membrane import YNL137c NAM9 ribosomal protein, mitochondrial YFL036w RPO41 DNA-directed RNA polymerase, receptor subunit, 6K YOR158w PET123 ribosomal protein, mitochondrial mitochondrial YNL070w TOM7 mitochondrial outer membrane import YCR046c PETCR46 ribosomal protein, mitochondrial YBR252w DUT1 dUTP pyrophosphatase, mitochondrial receptor subunit, 7K YFR049w YMR31 ribosomal protein, mitochondrial YOR211c MGM1 dynamin-like protein YNL055c POR1 mitochondrial outer membrane porin YDR194c MSS116 RNA helicase of the DEAD box family, YGR207c ETF-β electron-transferring flavoprotein, YNL121c TOM70 mitochondrial outer membrane mitochondrial β subunit specialized import receptor YMR228w MTF1 RNA polymerase specific factor, YLR393w ATP10 F1F0 ATPase complex assembly protein YGL143c MRF1 mitochondrial peptide chain release factor mitochondrial YNL315c ATP11 F1F0-ATPase complex assembly protein YLR163c MAS1 mitochondrial processing peptidase YOR334w MRS2 RNA splicing protein and member of the YJL180c ATP12 F1F0-ATPase complex assembly protein YHR024c MAS2 mitochondrial processing peptidase, mitochondrial carrier family (MCF) YKL016c ATP7 F1F0-ATPase complex, F0 D subunit catalytic 53K (α) subunit YJL133w MRS3 RNA splicing protein and member of the YBL099w ATP1 F1F0-ATPase complex, F1 α subunit YMR150c IMP1 mitochondrial protease mitochondrial carrier family (MCF) YJR121w ATP2 F1F0-ATPase complex, F1 β subunit YDR375c BCS1 mitochondrial protein of the YKR052c MRS4 RNA splicing protein and member of the YDL004w ATP16 F1F0-ATPase complex, F1 δ subunit CDC48/PAS1/SEC18 (AAA) family of mitochondrial carrier family (MCF) YPL078c ATP4 F1F0-ATPase complex, F1 δ subunit ATPases YOR201c PET56 rRNA (guanosine-2’-O-)-methyltransferase YPL271w ATP15 F1F0-ATPase complex, F1 ε subunit YDR120c TRM1 N2,N2-dimethylguanine tRNA YBR263w SHM1 serine hydroxymethyltransferase, YBR039w ATP3 F1F0-ATPase complex, F1 γ subunit methyltransferase mitochondrial YDR298c ATP5 F1F0-ATPase complex, OSCP subunit YML120c NDI1 NADH-ubiquinone-6 oxidoreductase YPR037c similarity to Erv1p and rat ALR protein YLR295c ATP14 F1F0-ATPase complex, subunit h YOR355w GDS1 nam9-1 suppressor YDR376w ARH1 similarity to human adrenodoxin YIL134w FLX1 FAD carrier protein, mitochondrial (MCF) YJL208c NUC1 nuclease, mitochondrial reductase YPL172c COX10 farnesyl transferase YAR035w YAT1 outer carnitine acetyltransferase, YBL013w similarity to methionyl-tRNA YOR176w HEM15 ferrochelatase mitochondrial formyltransferase YPL262w FUM1 fumarate hydratase YNR041c COQ2 para-hydroxybenzoate- YJR113c similarity to mitochondrial ribosomal YOL033w MSE1 glutamyl-tRNA synthetase, mitochondrial polyprenyltransferase protein S7 YOL059w GPD3 glycerol-3-phosphate dehydrogenase YPR047w MSF1 phenylalanine-tRNA ligase α subunit, YKL120w PMT similarity to mitochondrial uncoupling (NAD+), mitochondrial mitochondrial protein (MCF) YIL155c GUT2 glycerol-3-phosphate dehydrogenase, YJR077c MIR1 phosphate transport protein, YMR244w similarity to NCA3 and SUN4 protein mitochondrial mitochondrial (MCF) YOR150w similarity to ribosomal protein L13 YMR189w GSD2 glycine decarboxylase subunit YNL169c PSD1 phosphatidylserine decarboxylase 1 YPR134w MSS18 splicing protein YDR019c GCV1 glycine decarboxylase T subunit YLR203c MSS51 possibly involved in translational YGR222w PET54 splicing protein and translational activator, YFL016c MDJ1 heat-shock protein - chaperone activation of COX1 and COB mRNA mitochondrial YOR232w MGE1 heat-shock protein - chaperone YGL068w probable ribosomal protein L12 YCR028c-a RIM1 ssDNA-binding protein, mitochondrial YLR259c HSP60 heat-shock protein - chaperone, YLR168c (MSF1) probably involved in intramitochondrial YKL192c strong similarity to acyl-carrier proteins mitochondrial protein sorting YBR024w SCO2 strong similarity to Sco1p YJR045c SSC1 heat-shock protein 70-related protein, YLR142w PUT1 proline oxidase YHR117w TOM71 strong similarity to Tom70p/Mas70p mitochondrial YER017c AFG3 protease of the SEC18/CDC48/PAS1 YKL148c SDH1 succinate dehydrogenase flavoprotein YDR258c HSP78 heat-shock protein of clpb family of ATP- family of ATPases (AAA) YLL041c SDH2 succinate dehydrogenase iron-sulphur dependent proteases, mitochondrial YPR024w YME1 protease of the SEC18/CDC48/PAS1 protein subunit YBR003w COQ1 hexaprenyl pyrophosphate synthetase family of ATPases (AAA) YDR178w SDH4 succinate dehydrogenase membrane YMR072w ABF2 high mobility group protein YMR089c YTA12 protease of the SEC18/CDC48/PAS1 anchor subunit for Sdh2p YAL039c CYC3 holocytochrome c synthase (cytochrome family of ATPases (AAA) YHR008c SOD2 superoxide dismutase (Mn), mitochondrial c haem lyase) YDL044c MTF2 protein involved in mRNA splicing and YHR050w SMF2 suppressor of mitochondrial matrix YKL087c CYT2 holocytochrome c1 synthase protein synthesis, mitochondrial mutant YMR038c LYS7 homocitrate dehydrogenase YIL136w OM45 protein of the outer mitochondrial YKL194c MST1 threonine-tRNA ligase, mitochondrial YDL181w INH1 inhibitor of mitochondrial ATPase membrane YLR069c MEF1 translation elongation factor G, YMR267w PPA2 inorganic pyrophosphatase, mitochondrial YAL011w FUN36 protein of unknown function mitochondrial YLL009c COX17 interacts genetically with SCO1 and SCO2 YJL023c PET130 protein synthesis protein, mitochondrial YOR187w TUF1 translation elongation factor TU, in cytochrome oxidase assembly YER014w HEM14 protoporphyrinogen oxidase, mitochondrial YGR028w MSP1 intra-mitochondrial sorting protein mitochondrial YJL102w MEF2 translation elongation factor, YJR034w PET191 involved in assembly of cytochrome YER178w PDA1 pyruvate dehydrogenase (lipoamide) mitochondrial oxidase α subunit YOL023w IFM1 translation initiation factor 2, mitochondrial YMR302c PRP12 involved in early maturation of pre-rRNA YBR221c PDB1 pyruvate dehydrogenase (lipoamide) YDL069c CBS1 translational activator of cob mRNA YOL009c MDM12 involved in mitochondrial inheritance β subunit YER153c PET122 translational activator of cytochrome c YAL010c MDM10 involved in mitochondrial morphology and YGR193c PDX1 pyruvate dehydrogenase complex protein oxidase subunit III inheritance X YNR045w PET494 translational activator, mitochondrial YIR021w MRS1 involved in mitochondrial RNA splicing of YJR095w ACR1 regulator of acetyl-CoA synthetase activity YOR274w MOD5 tRNA isopentenyltransferase COB mRNA YBR091c MRS5 regulator of mitochondrial intron splicing YER168c CCA1 tRNA nucleotidyltransferase YBR037c SCO1 involved in stabilization of Cox1p and YPL215w CBP3 required for assembly of cytochrome bc1 YDR268w MSW1 tryptophanyl-tRNA synthetase, Cox2p complex mitochondrial YNL066w SUN4 involved in the aging process YEL059c-a SOM1 required for mitochondrial Imp1 peptidase YPL097w MSY1 tyrosyl-tRNA synthetase YCL017c NFS1 involved in tRNA processing and function YFR033c QCR6 ubiquinol-cytochrome c reductase 17K mitochondrial metabolsim YLL006w MMM1 required for mitochondrial shape and protein YNL037c IDH1 isocitrate dehydrogenase (NAD+) subunit structure YPR191w QCR2 ubiquinol-cytochrome c reductase 40K 1, mitochondrial YKL093w MBR1 required for optimal growth on glycerol subunit II YOR136w IDH2 isocitrate dehydrogenase (NAD+) subunit YLR067c PET309 required for stability and translation of YBL045c COR1 ubiquinol-cytochrome c reductase 44K 2, mitochondrial COX1 mRNA core protein YDL066w IDP1 isocitrate dehydrogenase (NADP+), YMR257c PET111 required for translation of COX2 mRNA YHR001w-a QCR10 ubiquinol-cytochrome c reductase 8.5K mitochondrial YBL080c PET112 required to maintain RHO+ mitochondrial subunit YPL040c ISM1 isoleucine-tRNA ligase, mitochondrial DNA YGR174c CBP4 ubiquinol-cytochrome c reductase YLR355c ILV5 ketol-acid reducto-isomerase YBR185c MBA1 respiratory chain assembly protein assembly factor YML054c CYB2 lactate dehydrogenase cytochrome b2 YML091c RPM2 ribonuclease P, mitochondrial YGL119w ABC1 ubiquinol-cytochrome c reductase YLR382c NAM2 leucine-tRNA ligase, mitochondrial YKL170w MRPL38 ribosomal protein L14, mitochondrial complex assembly protein YOR196c LIP5 lipoic acid synthase YJL063c MRPL8 ribosomal protein L17, mitochondrial YEL024w RIP1 ubiquinol-cytochrome c reductase iron- YNL073w MSK1 lysyl-tRNA synthetase, mitochondrial YPR166c MRP2 ribosomal protein S14 sulphur protein YKL085w MDH1 malate dehydrogenase, mitochondrial YPL013c ribosomal protein S16, mitochondrial YDR529c QCR7 ubiquinol-cytochrome c reductase subunit YOR130c ARG11 member of the mitochondrial carrier YBR251w MRPS5 ribosomal protein S5, mitochondrial 7 family (MCF) YBR146w MRPS9 ribosomal protein S9, mitochondrial YGR183c QCR9 ubiquinol-cytochrome c reductase subunit YDL198c YHM1 member of the mitochondrial carrier YKR006c MRPL13 ribosomal protein YmL13, mitochondrial 9 family (MCF) YNL005c MRPL2 ribosomal protein YmL2, mitochondrial YJL166w QCR8 ubiquinol-cytochrome c reductase subunit YGR171c MSM1 methionyl-tRNA synthetase YKR085c MRPL20 ribosomal protein YmL20, mitochondrial VIII YGR029w ERV1 mitochondrial biogenesis and regulation YBR282w MRPL27 ribosomal protein YmL27, mitochondrial YML021c UNG1 uracil-DNA glycosylase of cell cycle YDR462w ribosomal protein YmL28, mitochondrial YGR094w VAS1 valyl-tRNA synthetase YBR192w RIM2 mitochondrial carrier protein (MCF) YNL252c ribosomal protein YmL30, mitochondrial YIL114c POR2 voltage-dependent anion channel YPR058w YMC1 mitochondrial carrier protein (MCF) YKL138c MRPL31 ribosomal protein YmL31, mitochondrial (YVDAC2) YBR104w YMC2 mitochondrial carrier protein (MCF) YCR003w MRPL32 ribosomal protein YmL32, mitochondrial YNL237w YTP1 weak similarity to mitochondrial electron YOR020c HSP10 mitochondrial chaperonin YBR122c MRPL36 ribosomal protein YmL36, mitochondrial transport proteins YJR144w MGM101 mitochondrial genome maintenance YBR268w MRPL37 ribosomal protein YmL37, mitochondrial protein YPL173w ribosomal protein YmL40, mitochondrial peroxisomal organization and biogenesis YMR023c MSS1 mitochondrial GTPase involved in YGR076c MRPL25 ribosomal protein YmR26 (YML25), expression of COX1 mitochondrial YIL160c POT1 acetyl-CoA C-acyltransferase, peroxisomal YNR017w MAS6 mitochondrial inner membrane import YMR225c MRPL44 ribosomal protein YmR44, mitochondrial YAL054c ACS1 acetyl-CoA synthetase translocase subunit YML025c ribosomal protein, mitochondrial YGL205w POX1 acyl-CoA oxidase YJL143w TIM17 mitochondrial inner membrane import YDR347w MRP1 ribosomal protein, mitochondrial YBR222c PCS60 AMP-binding protein, peroxisomal translocase subunit YGR084c MRP13 ribosomal protein, mitochondrial YML042w CAT2 carnitine O-acetyltransferase YIL022w TIM44 mitochondrial inner membrane import YKL003c MRP17 ribosomal protein, mitochondrial YDR256c CTA1 catalase A, peroxisomal translocase subunit YDR405w MRP20 ribosomal protein, mitochondrial YCR005c CIT2 citrate (si)-synthase, peroxisomal YMR035w IMP2 mitochondrial inner membrane protease YHL004w MRP4 ribosomal protein, mitochondrial YKR009c FOX2 hydratase-dehydrogenase-epimerase, subunit YKL167c MRP49 ribosomal protein, mitochondrial peroxisomal YKL134c (MIP1) mitochondrial intermediate peptidase YKL142w MRP8 ribosomal protein, mitochondrial YER065c ICL1 isocitrate lyase YLR312w-a MRPL15 ribosomal protein, mitochondrial YKL188c PAT1 long-chain-fatty-acid transporter

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YPL147w PXA1 long-chain-fatty-acid transporter YPR036w VMA13 H+-ATPase V1 domain 54K subunit, YLR371w ROM2 GDP/GTP exchange protein for Rho1p YER015w FAA2 long-chain-fatty-acid-CoA ligase vacuolar YPL115c BEM3 GTPase-activating protein for Cdc42p and YDL078c MDH3 malate dehydrogenase, peroxisomal YBR127c VMA2 H+-ATPase V1 domain 60K subunit, Rho1p YNL117w MLS1 malate synthase 1 vacuolar YLR229c CDC42 GTP-binding protein of RAS superfamily YIR031c DAL7 malate synthase 2 YDL185w TFP1 H+-ATPase V1 domain 69K subunit, YPR165w RHO1 GTP-binding protein of the RHO subfamily YDR329c PAS3 peroxisomal assembly protein vacuolar of RAS-like proteins YDR265w PAS4 peroxisomal assembly protein YFR019w FAB1 probable PI P 5-kinase YNL090w RHO2 GTP-binding protein of the RHO subfamily YJL210w PAS5 peroxisomal assembly protein YEL060c PRB1 protease B, vacuolar of RAS-like proteins YNL329c PAS8 peroxisomal assembly protein YDR481c PHO8 repressible vacuolar alkaline phosphatase YPL106c SSE1 heat-shock protein of HSP70 family YDR142c PAS7 peroxisomal import protein YIL099w SGA1 sporulation specific glucan YOR149c SMP3 protein kinase C pathway protein YOL147c PMP27 peroxisomal membrane protein 1,4-—glucosidase YPL140c MKK2 protein kinase of the MAP kinase kinase YLR191w PAS20 peroxisomal protein involved in protein YOR036w PEP12 syntaxin (T-SNARE) (MEK) family import YOR106w VAM3 syntaxin related protein YDL135c RDI1 RHO GDP dissociation inhibitor with YDR244w PAS10 putative peroxisomal targeting signal YMR231w PEP5 vacuolar biogenesis protein activity towards Rho1p receptor YLR148w PEP3 vacuolar membrane protein YOR231w MKK1 ser/thr protein kinase YLR109w similarity to C. boidinii peroxisomal YGL212w VAM7 vacuolar morphogenesis protein YBL105c PKC1 ser/thr protein kinase membrane protein 20K A YJL053w PEP8 vacuolar protein-sorting/targeting protein YHR030c SLT2 ser/thr protein kinase of MAP kinase YGR077c similarity to peroxisomal matrix protein YJL154c VPS35 vacuolar protein-sorting protein family Per1p YDR323c PEP7 vacuolar segregation protein YJL095w BCK1 ser/thr protein kinase of the MEKK family YLR251w similarity to peroxisomal rat membrane YPL045w VPS16 vacuolar sorting protein YER167w BCK2 ser/thr protein kinase of the protein protein PMP22 YDR495c VPS3 vacuolar sorting protein kinase C pathway YNL202w SPS19 sporulation-specific protein YLR396c VPS33 vacuolar sorting protein YOL113w SKM1 Ste20p/PAK-like protein kinase YGR133w PAS2 ubiquitin-conjugating enzyme YPR173c VPS4 vacuolar sorting protein YGL106w strong similarity to calmodulins YBR204c weak similarity to peroxisomal serine- YKL161c strong similarity to ser/thr-specific protein active lipase other cellular organization and biogenesis kinase Slt2p activities YPL089c RLM1 transcription factor of the MADS box endosomal organization and biogenesis family YKL157w APE2 aminopeptidase yscII YGL095c VPS45 vacuolar protein sorting-associated YKL135c APL2 β-adaptin YIL015w BAR1 barrier pepsin protein YNL192w CHS1 chitin synthase I YJL174w KRE9 cell wall synthesis protein YBR023c CHS3 chitin synthase III YBR092c PHO3 constitutive acid phosphatase osmosensing YJR058c APS2 clathrin-associated protein 17, small YLR286c CTS1 endochitinase subunit YLR300w EXG1 exo-1,3-—glucanase (I/II), major isoform YDL022w GPD1 glycerol-3-phosphate dehydrogenase YJR005w APL1 clathrin-associated protein complex, YIR019c STA1 extracellular α-1,4-glucan glucosidase (NAD+), cytoplasmic β subunit YPL187w MFα1 mating pheromone α-1 factor YFL014w HSP12 heat-shock protein YBR288c APM3 clathrin-associated protein complex, YGL089c MFα2 mating pheromone α-2 factor YER118c SSU81 involved in the HOG1 high-osmolarity medium subunit YDR461w MFA1 mating pheromone a-factor 1 signal transduction pathway YLR170c APS1 clathrin-associated protein complex, small YNL145w MFA2 mating pheromone a-factor 2 YCR073c SSK22 MAP kinase kinase kinase subunit AP19 YKL163w PIR3 member of the Pir1p/Pir2p/Pir3p family YNR031c SSK2 MAP kinase kinase kinase of the high- YDL145c RET1 coatomer complex α subunit YBR093c PHO5 repressible acid phosphatase osmolarity signal transduction pathway YDR238c SEC26 coatomer complex β subunit of secretory YKL164c PIR1 required for tolerance to heat-shock YDL006w PTC1 protein ser/thr phosphatase 2c pathway vesicles YML008c ERG6 S-adenosyl-methionine δ-24-sterol-c- YLR113w HOG1 ser/thr protein kinase of MAP kinase YGL137w SEC27 coatomer complex β ´ subunit methyltransferase (MAPK) family YFR051c RET2 coatomer complex δ subunit YAR071w PHO11 secreted acid phosphatase YHR030c SLT2 ser/thr protein kinase of MAP kinase YNL287w SEC21 coatomer complex γ subunit YHR215w PHO12 secreted acid phosphatase family YPL010w RET3 coatomer complex ζ subunit YNL160w YGP1 secreted glycoprotein YKL161c strong similarity to ser/thr-specific protein YPR181c SEC23 component of COPII coat of ER-golgi YLR250w SSP120 secretory protein kinase Slt2p vesicles YBR046c ZTA1 similarity to ζ-crystallin YIL147c SLN1 two-component signal transducer YDR170c SEC7 component of non-clathrin vesicle coat YMR215w similarity to GAS1 protein YLR006c SSK1 two-component signal transducer YLR083c EMP70 endosomal protein YNL275w similarity to human band 3 anion YJL128c PBS2 tyrosine protein kinase of the MAP kinase YPR017c DSS4 GDP/GTP exchange factor for Sec4p transport protein kinase family YOR089c VPS21 GTP-binding protein YIL162w SUC2 sucrose hydrolyzing enzyme YDR069c DOA4 ubiquitin-specific protease YDL137w ARF2 GTP-binding protein of the ARF family YML001w YPT7 GTP-binding protein of the RAB family nutritional response YFL005w SEC4 GTP-binding protein of the RAS superfamily Signal transduction YJL005w CYR1 adenylate cyclase YLR268w SEC22 high copy suppressor of ypt1 null YLR178c TFS1 cdc25-dependent nutrient- and ammonia- mutation pheromone response generation response cell-cycle regulator YPL085w SEC16 multidomain vesicle protein YBR195c MSI1 chromatin assembly complex, subunit YLR208w SEC13 protein transport protein YDR264c AKR1 ankyrin repeat-containing protein p50 YKL196c similarity to Sec22p YPL161c BEM4 bud emergence protein YLL016w SDC25 GDP/GTP exchange factor YLR080w strong similarity to Emp47p YCL027w FUS1 cell fusion protein YLR310c CDC25 GDP/GTP exchange factor for Ras1p and YDR107c strong similarity to Emp70p YNL053w MSG5 dual-specifity protein phosphatase Ras2p YAL030w SNC1 strong similarity to synaptic vesicle- YJL157c FAR1 factor arrest protein YOR101w RAS1 GTP-binding protein associated membrane protein YAL041w CDC24 GDP/GTP exchange factor for Cdc42p YNL098c RAS2 GTP-binding protein YOR327c SNC2 strong similarity to synaptobrevin YHR005c GPA1 GTP-binding protein α subunit of the YER020w GPA2 guanine nucleotide-binding regulatory YBL050w SEC17 transport vesicle fusion protein pheromone pathway protein YNR006w VPS27 vacuolar protein sorting-associated YOR212w STE4 GTP-binding protein β subunit of the YPL106c SSE1 heat-shock protein of HSP70 family protein pheromone pathway YBR140c IRA1 inhibitory regulator protein of the RAS- YBR080c SEC18 vesicular-fusion protein, functional YJR086w STE18 GTP-binding protein γ subunit of the cyclic AMP pathway homologue of NSF pheromone pathway YIL119c RPI1 negative regulator of RAS-cAMP pathway YLR078c BOS1 weak similarity to synaptobrevin YLR229c CDC42 GTP-binding protein of RAS superfamily YIR026c YVH1 protein tyrosine phosphatase (V-SNARE) YNL173c MDG1 GTP-binding protein of the pheromone YOR208w PTP2 protein-tyrosine-phosphatase pathway YOL110w SHR5 RAS suppressor vacuolar and lysosomal organization and YER020w GPA2 guanine nucleotide-binding regulatory YPL084w BRO1 required for normal response to nutrient biogenesis protein limitation YLR452c SST2 involved in desensitization to α-factor YLR362w STE11 ser/thr protein kinase of the MEKK family YGL156w AMS1 α-mannosidase pheromone YDL159w STE7 ser/thr/tyr protein kinase of MAP kinase YBR286w APE3 aminopeptidase Y, vacuolar YMR052w FAR3 involved in pheromone-mediated cell kinase family YKL103c LAP4 aminopeptidase yscI, vacuolar cycle arrest YHR084w STE12 transcriptional activator YPL154c PEP4 aspartyl protease YDR461w MFA1 mating pheromone a-factor 1 YDL128w VCX1 Ca2+-transport (H+/Ca2+ exchange) protein, YIL047c SYG1 member of the major facilitator other signal-transduction activities vacuolar superfamily YGL006w PMC1 Ca2+-transporting P-type ATPase YBL016w FUS3 mitogen-activated protein kinase (MAP YPL268w PLC1 1-phosphatidylinositol-4,5-bisphosphate YMR297w PRC1 carboxypeptidase y, serine-type protease kinase) phosphodiesterase YHR028c DAP2 dipeptidyl aminopeptidase B YFL026w STE2 pheromone α-factor receptor YNL138w SRV2 adenylate cyclase-associated protein, 70K YDR135c YCF1 glutathione S-conjugate transporter, YKL178c STE3 pheromone α-factor receptor YFR014c CMK1 Ca2+/calmodulin-dependent ser/thr vacuolar YCL032w STE50 pheromone response pathway protein protein kinase, type I YJL172w CPS1 Gly-X carboxypeptidase YSCS YDR103w STE5 pheromone signal transduction pathway YOL016c CMK2 Ca2+/calmodulin-dependent ser/thr YKL119c VPH2 H+-ATPase assembly protein, vacuolar protein protein kinase, type II YHR039c-a VMA10 H+-ATPase V0 domain 13K subunit, YGR040w KSS1 ser/thr protein kinase of the MAP kinase YPL203w TPK2 cAMP-dependent protein kinase 2, vacuolar family catalytic subunit YEL027w CUP5 H+-ATPase V0 domain 17K subunit, YLR362w STE11 ser/thr protein kinase of the MEKK family YKL166c TPK3 cAMP-dependent protein kinase 3, vacuolar YHL007c STE20 ser/thr protein kinase of the pheromone catalytic subunit YPL234c TFP3 H+-ATPase V0 domain 17K subunit, pathway YJL164c SRA3 cAMP-dependent protein kinase, catalytic vacuolar YDL159w STE7 ser/thr/tyr protein kinase of MAP kinase subunit 1 YLR447c VMA6 H+-ATPase V0 domain 36K subunit, kinase family YMR028w TAP42 component of the Tor signalling pathway vacuolar YHR146w similarity to pheromone-response YML064c TEM1 GTP-binding protein of the RAS YOR270c VPH1 H+-ATPase V0 domain 95K subunit, G-protein YNL173c superfamily vacuolar YHR084w STE12 transcriptional activator YJL146w IDS2 IME2-dependent signalling protein YGR020c VMA7 H+-ATPase V1 domain 14K subunit, YJR066w TOR1 phosphatidylinositol 3-kinase vacuolar morphogenesis YKL203c TOR2 phosphatidylinositol 3-kinase YOR332w VMA4 H+-ATPase V1 domain 27K subunit, YLR240w VPS34 phosphatidylinositol 3-kinase vacuolar YBR200w BEM1 bud emergence mediator YNL267w PIK1 phosphatidylinositol 4-kinase YEL051w VMA8 H+-ATPase V1 domain 32K subunit, YPL161c BEM4 bud emergence protein YNL106c PIE3 phosphatidylinositol phosphate vacuolar YBR109c CMD1 calmodulin phosphatase YKL080w VMA5 H+-ATPase V1 domain 42K subunit, YAL041w CDC24 GDP/GTP exchange factor for Cdc42p YLR305c STT4 phosphatidylinositol-4-kinase vacuolar YGR070w ROM1 GDP/GTP exchange protein for Rho1p YDL101c DUN1 protein kinase

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YHR079c IRE1 protein kinase YGL178w MPT5 multicopy suppressor of pop2 YDR059c UBC5 ubiquitin-conjugating enzyme YMR016c SOK2 regulatory protein in the PKA signal YGR159c NSR1 nuclear localization sequence binding YER125w RSP5 ubiquitin-protein ligase transduction pathway protein YKL210w UBA1 ubiquitin-protein ligase YGR216c GPI1 required for N-acetylglucosaminyl YGL115w SNF4 nuclear regulatory protein phosphatidylinositol synthesis YJR051w OSM1 osmotic growth protein DNA repair (direct repair, base excision repair YPL153c SPK1 ser/thr/tyr protein kinase YMR175w SIP18 osmotic stress protein and nucleotide excision repair) YHR046c similarity to bovine myo-inositol-1(or 4)- YBR070c SAT2 osmotolerance protein monophosphatase YHR057c CYP2 peptidyl-prolyl cis-trans isomerase YER142c MAG1 3-methyladenine DNA glycosylase YBR260c similarity to C. elegans GTPase-activating YOR014w RTS1 potential regulatory subunit of protein YML060w OGG1 8-oxoguanine DNA glycosylase protein phosphatase 2A YKL114c APN1 AP endonuclease YGR136w similarity to chicken growth factor YMR174c PAI3 protease A (ysca) inhibitor IA3 YJL092w HPR5 ATP-dependent DNA helicase receptor-binding protein GRB2 homologue YHR079c IRE1 protein kinase YPL204w HRR25 casein kinase I, ser/thr/tyr protein kinase YDR379w similarity to Dbm1p YPL140c MKK2 protein kinase of the MAP kinase kinase YPL022w RAD1 component of the nucleotide excision YDR208w MSS4 similarity to human PI P 5-kinase (MEK) family repairosome YCR027c similarity to human Ras-related GTP- YOL064c MET22 protein ser/thr phosphatase YDL108w KIN28 cyclin-dependent ser/thr protein kinase binding protein YDL006w PTC1 protein ser/thr phosphatase 2c YOR386w PHR1 deoxyribodipyrimidine photo-lyase YDR287w similarity to inositol monophosphatase YDR436w PPZ2 protein ser/thr phosphatase of the PP-1 YOR368w RAD17 DNA damage checkpoint control protein YLR150w MPT4 specific affinity for guanine-rich family YER176w DNA dependent ATPase/DNA helicase B quadruplex nucleic acids YOR208w PTP2 protein-tyrosine-phosphatase YLR032w RAD5 DNA helicase YPR054w SMK1 sporulation-specific MAP kinase YJR090c GRR1 required for glucose repression and for YIL143c SSL2 DNA helicase YNL132w strong similarity to A. ambisexualis glucose and cation transport YML061c PIF1 DNA helicase involved in mitochondrial antheridiol steroid receptor YPL084w BRO1 required for normal response to nutrient DNA repair and telomere length YHR206w SKN7 transcription factor with similarity to Hsf1p limitation YER171w RAD3 DNA helicase/ATPase YKL164c PIR1 required for tolerance to heat-shock YDL164c CDC9 DNA ligase YPR005c HAL1 salt-induced protein YEL019c MMS21 DNA repair protein YNL160w YGP1 secreted glycoprotein YAL015c NTG1 DNA repair protein Cell rescue YGL190c CDC55 ser/thr phosphatase 2A regulatory YMR137c PSO2 DNA repair protein subunit B YML095c RAD10 DNA repair protein stress response generation YML016c PPZ1 ser/thr phosphatase required for normal YCR066w RAD18 DNA repair protein osmoregulation YER095w RAD51 DNA repair protein YFR052w NIN1 26S proteasome regulatory subunit YJL165c HAL5 ser/thr protein kinase YDR076w RAD55 DNA repair protein YIL075c SEN3 26S proteasome regulatory subunit YOR231w MKK1 ser/thr protein kinase YDR004w RAD57 DNA repair protein YDR074w TPS2 α,α-trehalose-phosphate synthase, 105K YBL105c PKC1 ser/thr protein kinase YOR346w REV1 DNA repair protein subunit YLR113w HOG1 ser/thr protein kinase of MAP kinase YDR369c XRS2 DNA repair protein YBR126c TPS1 α,α-trehalose-phosphate synthase, 56K (MAPK) family YGL163c RAD54 DNA-dependent ATPase of the Snf2p subunit YHR030c SLT2 ser/thr protein kinase of MAP kinase family YPR026w ATH1 acid trehalase, vacuolar family YDL102w CDC2 DNA-directed DNA polymerase δ, YIL033c SRA1 cAMP dependent protein kinase, YDL025c ser/thr protein kinase of the DEAD/DEAH catalytic 125K subunit regulatory subunit box family YFR023w PES4 DNA-directed DNA polymerase ε YDR477w SNF1 carbon catabolite derepressing ser/thr YJL095w BCK1 ser/thr protein kinase of the MEKK family suppressor protein kinase YER167w BCK2 ser/thr protein kinase of the protein YNL262w POL2 DNA-directed DNA polymerase ε, catalytic YHR135c YCK1 casein kinase I isoform kinase C pathway subunit A YNL154c YCK2 casein kinase I isoform YDR227w SIR4 silencing regulatory protein YPL167c REV3 DNA-directed DNA polymerase ζ YGR088w CTT1 catalase T, cytosolic YKL088w similarity to C. tropicalis hal3 protein, to C- YKR056w RNC1 endo-exonuclease YDR251w PAM1 coiled-coil protein multicopy suppressor term. of Sis2p and to hypothetical protein YOL043c NTG2 endonuclease III-like glycosylase 2 of loss of PP2A YOR054c YER162c RAD4 excision repair protein YOR010c TIR2 cold shock induced protein YBR044c similarity to chaperonin HSP60 proteins YLR288c MEC3 G2-specific checkpoint protein YER011w TIR1 cold-shock induced protein of the Tir1p, YJR147w similarity to heat-shock transcription YFL014w HSP12 heat-shock protein Tip1p family factors YIL128w MMS19 involved in repair and RNA polymerase YDR155c CPH1 cyclophilin (peptidylprolyl isomerase) YGR249w MGA1 similarity to heat-shock transcription transcription YEL039c CYC7 cytochrome c isoform 2 factors YMR035w IMP2 mitochondrial inner membrane protease YER062c HOR2 DL-glycerol phosphatase YBR054w YRO2 similarity to HSP30 heat-shock protein subunit YDR263c DIN7 DNA damage inducible protein Yro1p YKR095w MLP1 myosin-like protein related to Uso1p YGL021w ALK1 DNA damage-responsive protein YAR020c similarity to members of the Srp1p/Tip1p YMR201c RAD14 nucleotide excision repair protein YAL015c NTG1 DNA repair protein family YBR114w RAD16 nucleotide excision repair protein YDR519w FKB2 FK506/rapamycin-binding protein of the YCR008w SAT4 similarity to Npr1p and Hal5p protein YEL037c RAD23 nucleotide excision repair protein ER kinases YJR052w RAD7 nucleotide excision repair protein YGR234w YHB1 flavohemoglobin YOR009w similarity to SRP1 and TIR2 proteins YDL200c MGT1 O6-methylguanine DNA repair YIR037w HYR1 glutathione peroxidase YCR060w similarity to stress inducible protein Sti1p methyltransferase YLL043w FPS1 glycerol channel protein YMR037c stress responsive regulatory protein YDL101c DUN1 protein kinase YNL098c RAS2 GTP-binding protein YOR027w STI1 stress-induced protein YML032c RAD52 recombination and DNA repair protein YHR064c heat-shock protein YBL009w strong similarity to DNA damage YIL139c REV7 required for DNA damage induced YMR173w DDR48 heat-shock protein responsive Alk1p mutagenesis YOL052c-a DDRA2 heat-shock protein YLR369w strong similarity to heat-shock protein 70- YBR073w RDH54 required for meiosis YMR186w HSC82 heat-shock protein related proteins YIL066c RNR3 ribonucleotide reductase, repair inducible YLL026w HSP104 heat-shock protein YHL046c strong similarity to members of the large subunit YFL014w HSP12 heat-shock protein Srp1p/Tip1p family YPL153c SPK1 ser/thr/tyr protein kinase YBR072w HSP26 heat-shock protein YIL011w strong similarity to members of the YDR061w similarity to E. coli deoxyribodipyrimidine YCR021c HSP30 heat-shock protein Srp1p/Tip1p family photolyase YPL240c HSP82 heat-shock protein YOL161c strong similarity to members of the YAL019w FUN30 similarity to helicases of the Snf2/Rad54 YFL016c MDJ1 heat-shock protein - chaperone Srp1p/Tip1p family family YLR259c HSP60 heat-shock protein - chaperone, YJL223c PAU1 strong similarity to members of the YLR035c similarity to human mutL protein mitochondrial Srp1p/Tip1p family homologue YJR045c SSC1 heat-shock protein 70-related protein, YEL049w PAU2 strong similarity to members of the YPR056w similarity to human transcription factor mitochondrial Srp1p/Tip1p family BTF2/TFIIH subunit p34 YDR258c HSP78 heat-shock protein of clpb family of ATP- YCR104w PAU3 strong similarity to members of the YFR038w strong similarity to mouse lymphocyte dependent proteases, mitochondrial Srp1p/Tip1p family specific helicase YEL030w heat-shock protein of HSP70 family YFL020c PAU5 strong similarity to members of the YOR206w strong similarity to Rad4p YAL005c SSA1 heat-shock protein of HSP70 family Srp1p/Tip1p family YGR258c RAD2 structure-specific nuclease of the YER103w SSA4 heat-shock protein of HSP70 family YLR461w PAU4 strong similarity to members of the nucleotide excision repairosome YPL106c SSE1 heat-shock protein of HSP70 family Tir1p/Tip1p family YDL088c ASM4 suppressor of temperature-sensitive YLL024c SSA2 heat-shock protein of HSP70 family, YNR076w PAU6 strong similarity to members of the mutations in Pol3p cytosolic Tir1p/Tip1p family YDR311w TFB1 TFIIH subunit (transcription initiation YBL075c SSA3 heat-shock protein of HSP70 family, YDR033w strong similarity to putative heat-shock factor), 75K cytosolic protein Yro2p YPR025c CCL1 TFIIH subunit (transcription initiation YBR169c SSE2 heat-shock protein of the HSP70 family YKL161c strong similarity to ser/thr-specific protein factor), cyclin C component YGL073w HSF1 heat-shock transcription factor kinase Slt2p YLR005w SSL1 TFIIH subunit (transcription initiation YMR251w-aHOR7 hyperosmolarity-responsive protein YOR054c strong similarity to SIS2 protein and C. factor), factor B YMR273c ZDS1 involved in negative regulation of cell tropicalis hal3 protein YPL122c TFB2 TFIIH subunit (transcription/repair factor) polarity YBR067c TIP1 temp.shock induced protein of the YDR460w TFB3 TFIIH subunit (transcription/repair factor) YER118c SSU81 involved in the HOG1 high-osmolarity Srp1p/Tip1p family YGL058w RAD6 ubiquitin-conjugating enzyme signal transduction pathway YGR144w THI4 thiamine-repressed protein YDR293c SSD1 involved in the tolerance to high YBL093c ROX3 transcription factor detoxificaton concentration of Ca2+ YGL181w GTS1 transcription factor of the YKL143w LTV1 low-temperature viability protein Gcs1p/Glo3p/Sps18p family YOL052c SPE2 adenosylmethionine decarboxylase YGR100w MIC1 Mac1p interacting protein YMR043w MCM1 transcription factor of the MADS box YFL050c ALR2 aluminum resistance protein YCR073c SSK22 MAP kinase kinase kinase family YML116w ATR1 aminotriazole and 4-nitroquinoline YNR031c SSK2 MAP kinase kinase kinase of the high- YHR206w SKN7 transcription factor with similarity to Hsf1p resistance protein osmolarity signal transduction pathway YKL062w MSN4 transcriptional activator YNL259c ATX1 antioxidant protein and metal YJL158c member of the Pir1p/Hsp150p/Pir3p YML007w YAP1 transcriptional activator involved in homeostasis factor family oxidative stress response YLR398c SKI2 antiviral protein and putative helicase YJL159w member of the Pir1p/Hsp150p/Pir3p YIL147c SLN1 two-component signal transducer YKL004w AUR1 aureobasidin-resistance protein family YLR006c SSK1 two-component signal transducer YDR256c CTA1 catalase A, peroxisomal YJL160c member of the Pir1p/Hsp150p/Pir3p YJL128c PBS2 tyrosine protein kinase of the MAP kinase YGR088w CTT1 catalase T, cytosolic family kinase family YJR104c SOD1 copper-zinc superoxide dismutase YKL163w PIR3 member of the Pir1p/Pir2p/Pir3p family YLL039c UBI4 ubiquitin YKR066c CCP1 cytochrome c peroxidase YMR021c MAC1 metal binding activator YMR022w QRI8 ubiquitin-conjugating enzyme YPR198w SGE1 drug resistance protein YNL064c YDJ1 mitochondrial and ER import protein YBR082c UBC4 ubiquitin-conjugating enzyme YJL101c GSH1 glutamate-cysteine ligase

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YDR513w TTR1 glutaredoxin YNL066w SUN4 involved in the ageing process YJR067c YAE1 protein of unknown function YPL091w GLR1 glutathione reductase (NADPH) YKR042w UTH1 involved in the ageing process YGR172c YIP1 protein of unknown function YDR135c YCF1 glutathione S-conjugate transporter, YHL003c LAG1 longevity-assurance protein YNL044w YIP3 protein of unknown function vacuolar YER167w BCK2 ser/thr protein kinase of the protein YBR111c YSA1 protein of unknown function YGR197c SNG1 involved in nitroguanidine resistance kinase C pathway YGR123c PPT1 protein ser/thr phosphatase YDL168w SFA1 long-chain alcohol dehydrogenase YDR227w SIR4 silencing regulatory protein YDL230w PTP1 protein tyrosine phosphatase YCR023c member of major facilitator superfamily YKL008c strong similarity to Lag1p YER075c PTP3 protein tyrosine phosphatase multidrug-resistance protein family 2 YIL123w strong similarity to Sun4p,Nca3p YPR073c LTP1 protein-tyrosine-phosphatase YNR055c HOL1 member of major facilitator superfamily YNL128w putative phosphatase multidrug-resistance protein subfamily 1 degradation of exogenous polynucleotides YCL039w regulatory protein of the β-transducin YHR053c CUP1A metallothionein family YHR055c CUP1B metallothionein YGL213c SKI8 antiviral protein of the β-transducin (WD- YJR055w HIT1 required for growth at high temperature YOR079c ATX2 multicopy suppressor of SOD-linked 40) repeat family YNL085w MKT1 required for propagation of M2 dsRNA defects satellite of L-A virus YDR011w SNQ2 multidrug resistance protein other cell-rescue activities YLL046c RNP1 ribonucleoprotein YHR042w NCP1 NADPH-cytochrome P450 reductase YOR046c DBP5 RNA helicase YOR018w ROD1 O-dinitrobenzene,calcium and zinc YPR189w SKI3 antiviral protein YDR466w ser/thr protein kinase resistance protein YJR069c HAM1 controls 6-N-hydroxylaminopurine YDR490c ser/thr protein kinase YKL064w MNR2 overexpression overcomes manganese sensitivity and mutagenesis YGL179c ser/thr protein kinase toxicity YGR213c RTA1 involved in 7-aminocholesterol resistance YGL180w ser/thr protein kinase YOR266w PNT1 pentamidine resistance factor YKL110c KTI12 involved in resistance to K. lactis killer YKL168c ser/thr protein kinase YDR538w PAD1 phenylacrylic acid decarboxylase toxin YKL171w ser/thr protein kinase YOR153w PDR5 pleiotropic drug resistance protein YER076c similarity to killer toxin Khr1p YLR063w ser/thr protein kinase YBL005w PDR3 pleiotropic drug resistance regulatory YER187w similarity to killer toxin KHS YMR291w ser/thr protein kinase protein YNL161w ser/thr protein kinase YGL016w PDR6 pleiotropic drug resistance regulatory YOL045w ser/thr protein kinase protein YOL100w ser/thr protein kinase YIL120w similarity to antibiotic resistance proteins Unclassified proteins YAR018c KIN3 ser/thr protein kinase YIL121w similarity to antibiotic resistance proteins YOR233w KIN4 ser/thr protein kinase YLR299w similarity to B. subtilis YEL052w AFG1 ATPase family gene YCR091w KIN82 ser/thr protein kinase γ-glutamyltransferase YDR184c BAT1 binds Aip3p YLL019c KNS1 ser/thr protein kinase YHL040c similarity to C. carbonum toxin pump YCR072c β-transducin family (WD-40 repeat) protein YHR082c KSP1 ser/thr protein kinase YHL047c similarity to C. carbonum toxin pump YLR459w CDC91 cell division control protein YDL079c MRK1 ser/thr protein kinase YBR180w similarity to drug resistance proteins YJL079c PRY1 contains homology to the plant PR-1 YOR267c ser/thr protein kinase with similarity to YDL100c similarity to E. coli arsenical pump-driving class of pathogen related proteins Npr1p ATPase YKR013w PRY2 contains homology to the plant PR-1 YMR216c ser/thr protein kinase with similarity to S. YLL015w similarity to metal resistance proteins class of pathogen related proteins pombe dsk1 YBR293w similarity to multidrug resistance proteins YJL078c PRY3 contains homology to the plant PR-1 YKL116c ser/thr protein kinase with similarity to S. YGR138c similarity to multidrug resistance proteins class of pathogen related proteins pombe nim1 protein YHR048w similarity to multidrug resistance proteins YOR302w CPA1-l CPA1 leader peptide YBL056w PTC3 ser/thr protein phosphatase PP2C YKR103w similarity to multidrug resistance proteins YML113w DAT1 datin, oligo(dA)/oligo(dT)-binding protein YDR507c GIN4 ser/thr-protein kinase YKR104w similarity to multidrug resistance proteins YKL020c SPT23 dosage-dependent suppressor of Ty- YKL126w YPK1 ser/thr-specific protein kinase YLL028w similarity to multidrug resistance proteins induced promotor mutations YOR007c similarities to protein phosphatases YPR156c similarity to multidrug resistance proteins YJL168c EZL1 enhancer of zeste-like YOR119c RIO1 similarity to a C. elegans ZK632.3 protein YOR273c similarity to resistance proteins YOR123c LEO1 extremely hydrophilic protein YLR405w similarity to A. brasilense nifR3 protein YOR251c similarity to thiosulphate YLL065w GIN11 growth inhibitory protein YML079w similarity to A. brasilense nifR3 protein sulphurtransferases YDL213c has an RNA recognition domain in the N- YML080w similarity to A. brasilense nifR3 protein YOR247w similarity to vanadate-sensitive terminal region YDR205w similarity to A. eutrophus cation efflux suppressor Svs1p YDR505c PSP1 high copy suppressor of ts of mutations system membrane protein czcD, rat zinc YJR025c strong similarity to 3-hydroxyanthranilate in DNA polymerase α transport protein ZnT-1 and Cot1p 3,4-dioxygenase YNL087w homology to YOR086c YDL228c similarity to A. klebsiana glutamate YOL130w strong similarity to Alr2p YLR161w identical to hypothetical proteins YLR156w dehydrogenase YMR279c strong similarity to aminotriazole and YLR161w YLL005c similarity to A. thaliana hyp1 protein resistance protein YLR156w identical to hypothetical proteins YLR159w YMR266w similarity to A. thaliana hyp1 protein YOR378w strong similarity to aminotriazole and YLR161w YOL084w similarity to A. thaliana hyp1 protein resistance protein YLR159w identical to hypothetical proteins YLR161w YNL317w similarity to A. thaliana PRL1 protein YBR008c strong similarity to benomyl/methotrexate and YLR156w YOL105c similarity to a-agglutinin core protein resistance protein YHR212c identical with hypothetical protein AGA1 and mucin proteins YCL069w strong similarity to drug resistance protein YAR060c YPL252c similarity to adrenodoxin and ferrodoxin SGE1 YHR214w identical with hypothetical protein YMR110c similarity to aldehyde dehydrogenase YKL026c strong similarity to glutathione peroxidase YAR066w YIL112w similarity to ankyrin and coiled-coil YBR244w strong similarity to glutathione YAR066w identical with hypothetical protein YIL169c proteins peroxidases YCR020c-a MAK31 involved in stability of L-A dsRNA- YLR064w similarity to Anopheles NADH-ubiquinone YKL033w-a strong similarity to holacid- containing particles oxidoreductase, subunit 4 halidohydrolase YPL049c DIG1 MAP kinase-associated protein, down- YMR153w similarity to Asm4p YFR022w strong similarity to Rod1p regulator of invasive growth YDR349c similarity to aspartyl proteases YLR046c strong similarity to Rta1p and Rtm1p YKL034w member of Kazal serine protease YDR072c similarity to Aur1p protein inhibitors family YMR305c similarity to B. japonicum putative β-(-6) YER185w strong similarity to Rtm1p YLR397c AFG2 member of the Sec18p, Pas1p, Cdc48p, glucan transferase YKR105c strong similarity to Sge1p and TBP-1 family of ATPases YDR291w similarity to B. subtilis helicases hypothetical protein YCL069w YCR007c member of the YBR302c family YPR201w similarity to B. subtilis hypothetical protein YJR015w strong similarity to Sng1p YGL036w MTC2 Mtf1 two hybrid clone 2 YPR002w similarity to B. subtilis mmgE protein YNR070w strong similarity to Snq2p YMR200w ROT1 mutant suppresses tor2 mutation YPL258c similarity to B. subtilis transcriptional YBL064c strong similarity to thiol-specific YAL059w SIM1 mutants are hypersensitive to calcofluor activator tenA, and strong similarity to antioxidant enzyme white hypothetical proteins YOL055c and YDR453c strong similarity to thiol-specific YCR019w MAK32 necessary for structural stability of L-A YPR121w antioxidant protein dsRNA-containing particles YPR121w similarity to B. subtilis transcriptional YGL254w FZF1 sulphite resistance protein YNL061w NOP2 nucleolar protein activator tenA, strong similarity to YPL092w SSU1 sulphite sensitivity protein YFR011c ochre suppressor tyr-tRNA hypothetical proteins YPL258c and YHR008c SOD2 superoxide dismutase (Mn), mitochondrial YLR196w PWP1 periodic tryptophan protein YOL055c YOR031w CRS5 suppressor of cup1 deletion, YDL235c YPD1 phosphorelay intermediate between Sln1p YIL159w similarity to BNI1 protein metallothionein-like protein and Ssk1p YDL119c similarity to bovine Graves disease carrier YML028w TSA1 thiol-specific antioxidant YOR014w RTS1 potential regulatory subunit of protein protein YLR043c TRX1 thioredoxin I phosphatase 2A YNR068c similarity to Bul1p YGR209c TRX2 thioredoxin II YOR181w LAS17 proline-rich protein YNL218w similarity to C. burnetii trxB, spoIIIE and YGL013c PDR1 transcription factor YER129w PAK1 protein kinase serS genes YMR043w MCM1 transcription factor of the MADS box YOR223w protein of unknown function YCR102c similarity to C. carbonum toxD gene family YHR093w AHT1 protein of unknown function YNL134c similarity to C. carbonum toxD gene YDR423c CAD1 transcriptional activator YDL167c ARP1 protein of unknown function YJR013w similarity to C. elegans B0491.1 protein YPL163c SVS1 vanadate sensitive suppressor YHR191c CTF8 protein of unknown function YPR040w similarity to C. elegans C02C2.6 protein YLL060c weak similarity to glutathione transferase YAL008w FUN14 protein of unknown function YGR257c similarity to C. elegans C16C10.1 YMR243c ZRC1 zinc- and cadmium resistance protein YAR002w FUN17 protein of unknown function YGR054w similarity to C. elegans E04D5.1 protein YAR014c FUN2 protein of unknown function YMR012w similarity to C. elegans hypothetical detoxification involving cytochrome P450 YAL031c FUN21 protein of unknown function 139.9K protein F55H2.6 YMR015c ERG5 C-22 sterol desaturase YAL014c FUN34 protein of unknown function YLR022c similarity to C. elegans hypothetical YDR402c DIT2 cytochrome P450 56 YAR008w FUN4 protein of unknown function protein YHR007c ERG11 cytochrome P450 lanosterol 14a- YAL033w FUN53 protein of unknown function YNL127w similarity to C. elegans hypothetical demethylase YDL234c GYP7 protein of unknown function protein YLL057c similarity to E. coli dioxygenase YPL054w LEE1 protein of unknown function YKL095w YJU2 similarity to C. elegans hypothetical YDR403w DIT1 spore wall maturation protein YDR335w MSN5 protein of unknown function protein YIR006c PAN1 protein of unknown function YML014w similarity to C. elegans hypothetical cell death and ageing YDL105w QRI2 protein of unknown function protein C14B1.5 YLR204w QRI5 protein of unknown function YKL099c similarity to C. elegans hypothetical YOR101w RAS1 GTP-binding protein YLL003w SFI1 protein of unknown function protein C16C10.2 YNL098c RAS2 GTP-binding protein YDR350c TCM10 protein of unknown function YEL004w similarity to C. elegans hypothetical YOL025w LAG2 involved in determining longevity YDL169c UGX2 protein of unknown function protein C53B4.6 YJL116c NCA3 involved in regulation of synthesis of YJR050w UTR3 protein of unknown function YHL030w similarity to C. elegans hypothetical Atp6p and Atp8p YEL035c UTR5 protein of unknown function protein D2045.2

60 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YOL093w similarity to C. elegans hypothetical YLR050c similarity to human MAC30 C-terminus YGL228w similarity to hypothetical protein YFR039c protein F25H8.1 YCR071c similarity to human NOF1 protein YBR281c similarity to hypothetical protein YFR044c YDL008w similarity to C. elegans hypothetical YOR001w similarity to human nucleolar 100K YDL001w similarity to hypothetical protein YFR048w, protein F35G12.9 polymyositis-scleroderma protein YDR282c and S. pombe hypothetical YKL151c similarity to C. elegans hypothetical YEL016c similarity to human nucleotide protein SPAC12G12.14 protein R107.2 pyrophosphatase YPL216w similarity to hypothetical protein YGL133w YDR196c similarity to C. elegans hypothetical YIL153w similarity to human phosphotyrosyl YPL219w similarity to hypothetical protein YGL134w protein T05G5.5 phosphatase activator YDR444w similarity to hypothetical protein YGL144c YJL029c similarity to C. elegans hypothetical YDR280w similarity to human PM-Scl-75 autoantigen and YDL1009c protein T05G5.8 YPR108w similarity to human protein GPS1 YLR047c similarity to hypothetical protein YGL160w YNL223w similarity to C. elegans hypothetical YLR206w similarity to human protein KIAA0171 and YER132c similarity to hypothetical protein YGL197w protein ZK792.1 hypothetical protein YDL161w YFR039c similarity to hypothetical protein YGL228w YOL003c similarity to C. elegans hypothetical YNL265c similarity to human protein KIAA0174 YHR036w similarity to hypothetical protein YGL247w protein, YDR126w, YNL326c and YLR246w YGR163w similarity to human ragA protein YGR031w similarity to hypothetical protein YGR015c YDR049w similarity to C. elegans K06H7.3 protein YDR096w GIS1 similarity to human retinoblastoma YGR015c similarity to hypothetical protein YGR031w YGR278w similarity to C. elegans LET-858 binding protein 2 YBR105c similarity to hypothetical protein YGR066c YHR004c similarity to C. elegans SPAC2F7.02c YDR378c similarity to human Sm protein F YLR373c similarity to hypothetical protein YGR071c protein YGR112w similarity to human SURF-1 protein YPR158w similarity to hypothetical protein YGR142w YML059c similarity to C. elegans ZK370.4 protein YGR080w similarity to human tyrosine kinase A6 YHR149c similarity to hypothetical protein YGR221c YNL168c similarity to C. elegans ZK688.3 protein YDL060w similarity to hypothetical C. elegans YHR158c similarity to hypothetical protein YGR238c and E. coli hpcEp protein YMR295c similarity to hypothetical protein YGR273c YPR188c similarity to calmodulin and calmodulin- YDR183w similarity to hypothetical C. elegans YMR310c similarity to hypothetical protein YGR283c related proteins protein YDR338c similarity to hypothetical protein YHR032w YPR128c similarity to carrier protein FLX1 YDR427w similarity to hypothetical C. elegans YGL247w similarity to hypothetical protein YHR036w YPL202c similarity to cell size regulation protein protein YDR309c similarity to hypothetical protein YHR061c Rcs1p YDR473c similarity to hypothetical C. elegans YNL075w similarity to hypothetical protein YHR088w YPR154w similarity to chicken growth factor protein YDR348c similarity to hypothetical protein YHR097c receptor-binding protein GRB2 homologue YER051w similarity to hypothetical C. elegans YNL144c similarity to hypothetical protein YHR131c YNL091w similarity to chicken h-caldesmon, Uso1p protein YNL156c similarity to hypothetical protein YHR133c and hypothetical protein YKL201c YGR145w similarity to hypothetical C. elegans YGR221c similarity to hypothetical protein YHR149c YPL176c similarity to chinese hamster transferrin protein YOR147w similarity to hypothetical protein YHR194w receptor protein YGR194c similarity to hypothetical C. elegans YER175c similarity to hypothetical protein YHR209w YDR259c similarity to Cin5p protein YJR108w similarity to hypothetical protein YIL015c-a YGL241w similarity to Cse1p YGR245c similarity to hypothetical C. elegans YER064c similarity to hypothetical protein YIL056w YNL305c similarity to C-term. of A. nidulans protein YLR036c similarity to hypothetical protein YIL089w regulatory protein (qutR) YHL010c similarity to hypothetical C. elegans YFL034c-b similarity to hypothetical protein YIL106w YPR127w similarity to C-term. of N. tabacum auxin- protein YNL058c similarity to hypothetical protein YIL117c induced protein YJR070c similarity to hypothetical C. elegans YNL074c YMK1 similarity to hypothetical protein YIL135c YDL112w similarity to C-terminus of human TRP-185 protein YKR100c similarity to hypothetical protein YIL158w protein YML094w similarity to hypothetical C. elegans YKR015c similarity to hypothetical protein YJL043w YMR304w similarity to D. melanogaster fat facets protein YBR273c similarity to hypothetical protein YJL048c gene YMR002w similarity to hypothetical C. elegans YLL031c similarity to hypothetical protein YJL062w YGR003w similarity to D. melanogaster lin19 protein protein YKR010c similarity to hypothetical protein YJL076w YLL013c similarity to D. melanogaster pumilio YJR072c similarity to hypothetical C. elegans YKR019c similarity to hypothetical protein YJL083w protein protein and YLR243w YKR029c similarity to hypothetical protein YJL105p YNL023c similarity to D. melanogaster shuttle craft YOL060c similarity to hypothetical C. elegans YDR131c similarity to hypothetical protein YJL149w protein protein M02F4.4 YDL123w similarity to hypothetical protein YJL151c YKL201c similarity to D. melanogaster sperm-tail- YDL097c similarity to hypothetical C. elegans YBR162c similarity to hypothetical protein YJL171c specific protein proteins YJR030c similarity to hypothetical protein YJL181w YCL001w-a similarity to Dom34p YER004w similarity to hypothetical E. coli and C. YJL181w similarity to hypothetical protein YJR030c YIL103w similarity to Dph2 protein elegans proteins YPR114w similarity to hypothetical protein YJR116w YGL018c similarity to E. coli dnaJ homologue YDL238c similarity to hypothetical E. coli protein YKL002w similarity to hypothetical protein YKL041w YHL014c YLF2 similarity to E. coli GTP-binding protein YDR013w similarity to hypothetical human KIAA0186 YMR031c similarity to hypothetical protein YKL050c YLR011w similarity to E. coli hypothetical 20.4K protein and human restin protein YDR496c similarity to hypothetical human protein YMR086w similarity to hypothetical protein YKL105c YGL037c similarity to E. coli hypothetical 23K YDR524c similarity to hypothetical human protein YMR171c similarity to hypothetical protein YKL124w protein YHR098c similarity to hypothetical human protein YMR115w similarity to hypothetical protein YKL133c YOR131c similarity to E. coli hypothetical 27K YOR294w similarity to hypothetical human protein YNL101w similarity to hypothetical protein YKL146w protein YOR215c similarity to hypothetical M. xanthus YJL076w similarity to hypothetical protein YKR010c YDR400w similarity to E. coli hypothetical 33.7K protein YJL043w similarity to hypothetical protein YKR015c protein in nfo-frua intergenic region YDR105c similarity to hypothetical mouse protein YJL083w similarity to hypothetical protein YKR019c YDR539w similarity to E. coli hypothetical 55.3K YDL193w similarity to hypothetical N. crassa 32K YJL105w similarity to hypothetical protein YKR029c protein in rfah-rfe intergenic region protein YIL158w similarity to hypothetical protein YKR100c YDR332w similarity to E. coli hypothetical protein YOR324c similarity to hypothetical protein YAL028w YLR019w similarity to hypothetical protein YLL010c YGR021w similarity to E. coli hypothetical protein YOR371c similarity to hypothetical protein YAL056w YNL328c similarity to hypothetical protein YLR008c YJL046w similarity to E. coli lipoate-protein ligase A YJR115w similarity to hypothetical protein YBL043w YPL063w similarity to hypothetical protein YLR019w YIL003w similarity to E. coli MRP protein YER093c-a similarity to hypothetical protein YBL059w and S. pombe hypothetical protein YOR165w similarity to E. histolytica surface lectin YPR030w similarity to hypothetical protein YBL101c SPAC2F7.02c YNR015w SMM1 similarity to E. histolytica nitrogen fixation YMR101c similarity to hypothetical protein YBR002c YIL089w similarity to hypothetical protein YLR036c regulatory protein-3 homologue YGR066c similarity to hypothetical protein YBR105c YLL023c similarity to hypothetical protein YLR064w YER113c similarity to Emp70p YJL171c similarity to hypothetical protein YBR162c YFL043c similarity to hypothetical protein YLR072w YDR036c similarity to enoyl-CoA hydratase YER145c similarity to hypothetical protein YBR207w YNR067c similarity to hypothetical protein YLR144c YOR172w similarity to finger protein YKL222c, YLR387c similarity to hypothetical protein YBR267w YDR501w similarity to hypothetical protein YLR183c YOR162c and YLR266c, weak similarity to YJL048c similarity to hypothetical protein YBR273c YNL278w similarity to hypothetical protein YLR187w transcription factors YFR044c similarity to hypothetical protein YBR281c YDR200c similarity to hypothetical protein YLR238w YOR162c similarity to finger proteins YKL222c, YDL177c similarity to hypothetical protein YCR059c YOR262w similarity to hypothetical protein YLR243w YOR162c and YLR266c, weak similarity to YDR282c similarity to hypothetical protein YDL001w, YDR126w similarity to hypothetical protein YLR246w transcription factors YFR048w and S. pombe hypothetical and YOL003c YOR338w similarity to FUN19 protein protein SPAC12G12.14 YOR137c similarity to hypothetical protein YLR361c YLR193c similarity to G. gallus px19 YDR425w similarity to hypothetical protein YDL113c YGR071c similarity to hypothetical protein YLR373c YKL054c similarity to glutenin, high molecular YLR426w similarity to hypothetical protein YDL114w YPR117w similarity to hypothetical protein YLR454w weight subunit YJL151c similarity to hypothetical protein YDL123w YDR458c similarity to hypothetical protein YML034w YOL132w similarity to glycophospholipid-anchored YDR233c similarity to hypothetical protein YDL204w YJR054w similarity to hypothetical protein YML047c surface glycoprotein GAS1 YER139c similarity to hypothetical protein YDR066c YPL184c similarity to hypothetical protein YML117w YHR168w similarity to GTP-binding proteins YNL249c MPA43 similarity to hypothetical protein YDR109c YKL050c similarity to hypothetical protein YMR031c YDL033c similarity to H. influenzae hypothetical YLR099c similarity to hypothetical protein YDR125c YKL105c similarity to hypothetical protein protein HI0174 YJL149w similarity to hypothetical protein YDR131c YMR086w YLL027w similarity to H. influenzae hypothetical YLR238w similarity to hypothetical protein YDR200c YKL133c similarity to hypothetical protein YMR115w protein HI0376 YDL204w similarity to hypothetical protein YDR233c YNL008c similarity to hypothetical protein YMR119w YLR419w similarity to helicases YHR061c similarity to hypothetical protein YDR309c YLR031w similarity to hypothetical protein YMR124w YMR128w similarity to helicases YHR080c similarity to hypothetical protein YDR326c, YPL228w similarity to hypothetical protein YMR180c YGR271w similarity to Hfm1p YFL042c and YLR072w YML118w similarity to hypothetical protein YMR285c YDR080w similarity to human (clone S53) mRNA, 3’ YOR012w similarity to hypothetical protein YDR391c YGR273c similarity to hypothetical protein YMR295c end of cds YDL113c similarity to hypothetical protein YDR425w YGR283c similarity to hypothetical protein YMR310c YLR051c similarity to human acidic 82K protein YML018c similarity to hypothetical protein YDR438w YMR119w similarity to hypothetical protein YNL008c YCR026c similarity to human autotaxin YML033w similarity to hypothetical protein YDR458c YIL117c similarity to hypothetical protein YNL058c YJL059w YHC3 similarity to human Batten disease-related YML034w similarity to hypothetical protein YDR458c YHR088w similarity to hypothetical protein YNL075w protein CLN3 YOR019w similarity to hypothetical protein YDR474c YHR131c similarity to hypothetical protein YNL144c YHR099w similarity to human DNA-PK YLR183c similarity to hypothetical protein YDR501w YHR133c similarity to hypothetical protein YNL156c YOL114c similarity to human DS-1 protein YCL036w similarity to hypothetical protein YDR514c YDL211c similarity to hypothetical protein YNL176c YJR036c similarity to human E6-associated protein YNR027w similarity to hypothetical protein YEL029c YLR187w similarity to hypothetical protein YNL278w YBR265w similarity to human FVT1 protein YGL197w similarity to hypothetical protein YER132c YDR214w similarity to hypothetical protein YNL281w YPL120w similarity to human GT197 (partial ORF) YDR066c similarity to hypothetical protein YER139c YLR008c similarity to hypothetical protein YNL328c YPR023c similarity to human hypothetical protein YBR207w similarity to hypothetical protein YER145c YEL029c similarity to hypothetical protein YNR027w YGL141w similarity to human hypothetical protein 1 YHR209w similarity to hypothetical protein YER175c YFR012w similarity to hypothetical protein YOL019w YPL217c similarity to human hypothetical protein YGL262w similarity to hypothetical protein YER187w YMR063w similarity to hypothetical protein YOL019w KIAA0187 and killer toxin KHS YOL083w similarity to hypothetical protein YOL082w YJR125c similarity to human KIAA0171 protein YPL100w similarity to hypothetical protein YFR021w YDR474c similarity to hypothetical protein YOR019w

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YKR078w similarity to hypothetical protein YOR069w YNL006w similarity to Met30p YGL164c similarity to S. pombe hypothetical protein YHR194w similarity to hypothetical protein YOR147w YNL293w similarity to Mic1p and human SPAC31A2.10 YAL028w similarity to hypothetical protein YOR324c transforming protein tre-2, and strong YPL236c similarity to S. pombe hypothetical protein YLR361c similarity to hypothetical protein similarity to hypothetical protein YOL112w SPAC3H1.13 YOR3329c YNR047w similarity to microtubule-associated YAL032c FUN20 similarity to S. pombe hypothetical protein YAL034c FUN19 similarity to hypothetical protein YOR338w ser/thr protein kinases SPAC8A4.06 YAL056w similarity to hypothetical protein YOR371c YPL137c similarity to microtubule-interacting protein YEL007w similarity to S. pombe pac2 protein YFR021w similarity to hypothetical protein YPL100w Mhp1p and to hypothetical protein YLR247c similarity to S. pombe rad8 protein YML117w similarity to hypothetical protein YPL184c YOR227w YJL062w similarity to S. pombe SPAC13G6.3 protein YGL133w similarity to hypothetical protein YPL216w YIL151c similarity to mitochondrial aldehyde YHR009c similarity to S. pombe YAM3 protein YGL134w similarity to hypothetical protein YPL219w dehydrogenase Ald1p YBL051c similarity to S. pombe Z66568_C protein YMR180c similarity to hypothetical protein YPL228w YGR058w similarity to mouse calcium-binding YOR240w similarity to S. pombe ZK1058.5 protein YMR181c similarity to hypothetical protein YPL229w protein YPL150w similarity to ser/thr kinases YJR116w similarity to hypothetical protein YPR114w YBL047c similarity to mouse eps15R protein YGR052w similarity to ser/thr protein kinases YLR454w similarity to hypothetical protein YPR117w YLR200w YKE2 similarity to mouse KE2 protein YAL017w FUN31 similarity to ser/thr protein kinases YOL027c similarity to hypothetical protein YPR125w YIL023c similarity to mouse MHC H-2K/t-w5-linked YOR090c similarity to ser/thr protein phosphatases YGR142w similarity to hypothetical protein YPR158w ORF YBR059c similarity to ser/thr-specific protein kinase YOL048c similarity to hypothetical proteins YAL018c YCR033w similarity to mouse nuclear receptor co- Pak1p and YOL047c repressor N-Cor YBR274w similarity to ser/thr-specific protein YOL047c similarity to hypothetical proteins YAL018c YER030w similarity to mouse nucleolin kinases and YOL048c YDR060w similarity to mouse putative CCAAT YLR118c similarity to several esterases YMR210w similarity to hypothetical proteins YBR177c binding factor 1 YMR077c similarity to SNF7 protein and YPL095c YBR187w similarity to mouse putative YLR313c similarity to SPA2 protein YML052w similarity to hypothetical proteins transmembrane protein FT27 YIR033w similarity to Spt23p YDL222c and YNL194c YGR284c similarity to mouse Surf-4 protein YBL109w similarity to subtelomeric encoded YLR246w similarity to hypothetical proteins YGR127w similarity to mouse T10 protein proteins YDR126w, YNL326c and YOL003c YMR192w similarity to mouse Tbc1 protein YEL074w similarity to subtelomeric encoded YER072w similarity to hypothetical proteins YPL249c similarity to mouse Tbc1 protein proteins YFL004w and YPL019c YHR181w similarity to mouse TEG-261 protein YGL263w similarity to subtelomeric encoded YLR072w similarity to hypothetical proteins YDR109c similarity to MPA43p proteins YFL042c, YFL043c, YDR326c and YDL038c similarity to mucin proteins YHL042w similarity to subtelomeric encoded YHR080c YER085c similarity to myosins proteins YGL028c similarity to hypothetical proteins YJL112w similarity to N. crassa sulphur controller-2 YHL043w similarity to subtelomeric encoded YGR279c and YMR305c YDR395w similarity to NMD and CSE1 proteins proteins YFL042c similarity to hypothetical proteins YPR072w similarity to N-terminal part of Cdc39p YHL044w similarity to subtelomeric encoded YHR080c, YDR326c and YLR072w YBL024w similarity to nucleolar Nop2p proteins YNL097c similarity to hypothetical proteins YDR071c similarity to O. aries arylalkylamine YIL177c similarity to subtelomeric encoded YHR090c and YHR090c N-acetyltransferase proteins YJR061w similarity to hypothetical proteins YKL200c YOL164w similarity to P. aeruginosa alkyl YKL219w similarity to subtelomeric encoded and YKL201c sulphatase proteins YMR313c similarity to hypothetical proteins YKR089c YMR099c similarity to P. ciliare possible apospory- YMR326c similarity to subtelomeric encoded and YOR081c associated protein proteins YOL019w similarity to hypothetical proteins YNR029c similarity to P. denitrificans cobW protein YLR177w similarity to suppressor protein Gin5p YMR063w and YFR012w YDR472w similarity to P. falciparum 41-2 protein YNL191w similarity to Synechocystis hypothetical YPR027c similarity to hypothetical proteins YNL019c antigen protein and YNL033w YNL136w similarity to P. falciparum mature-parasite- YGR036c similarity to T. denticola phosphatase YNL056w similarity to hypothetical proteins infected erythrocyte surface antigen YDR485c similarity to trichohyalin YNL032w and YNL099c MESA YOR195w similarity to USO1 protein YNL099c similarity to hypothetical proteins YIL010w similarity to P. falciparum merozoite cap YPL188w POS5 similarity to Utr1p and hypothetical protein YNL032w, YNL056w and YDR067c protein-1 YEL041w YNL032w similarity to hypothetical proteins YLR107w similarity to P. troglodytes prot GOR YLR213c similarity to UTR2 protein YNL099c, YNL056w and YDR067c YOL065c similarity to Pie3p and hypothetical YGR189c similarity to Utr2p YOL101c similarity to hypothetical proteins proteins YIL002c YGL220w similarity to V. alginolyticus bolA protein YOL002c and YDR492w YNL047c similarity to probable transcription factor YGR203w similarity to X. laevis protein-tyrosin- YNL326c similarity to hypothetical proteins Ask10p and hypothetical protein YPR115w, phosphatase cdc homologue 2 and to YOL003c, YLR246w and C. elegans and strong similarity to hypothetical hypothetical protein YPR200c hypothetical protein ZK757.1 protein YIL105c YDR284c similarity to YDR503c YML072c similarity to hypothetical proteins YBR125c similarity to protein phosphatase 2C YEL003w similarity to Yke2p YOR3141c and YNL087w and weak YNR038w similarity to Prp5p YIL135c similarity to Ymk1p similarity to synaptogamines YER150w similarity to putative cell surface YOL082w similarity to YOL083w YLR152c similarity to hypothetical proteins glycoprotein Sed1p YDR534c similarity to YOR383c,Sta1p and pig YOR3165w and YNL095c YGL099w similarity to putative human GTP-binding mucin YNL165w similarity to hypothetical proteins protein HSR1 YBL101c similarity to YPR030w YOR385w and YMR316w YPR062w similarity to R. corallinus N-ethylammeline YCR062w similarity to Ytp1p protein YMR316w similarity to hypothetical proteins chlorohydrolase trzA YFR024c-a strong similarity hypothetical protein YOR385w and YNL165w YJL055w similarity to R. fascians hypothetical YHR016c YDR083w similarity to hypothetical S. pombe protein protein 6 YPL151c strong similarity to A. thaliana PRL1 and YDR346c similarity to hypothetical S. pombe protein YOR191w similarity to RAD5 protein PRL2 proteins YGR272c similarity to hypothetical S. pombe protein YGL059w similarity to rat branched-chain α-ketoacid YOR034c strong similarity to Akr1p YLR241w similarity to hypothetical S. pombe protein dehydrogenase kinase YOR374w strong similarity to aldehyde YML005w similarity to hypothetical S. pombe protein YBR053c similarity to rat regucalcin dehydrogenase YOL098c similarity to hypothetical S. pombe protein YDL015c similarity to rat synaptic glycoprotein SC2 YIL113w strong similarity to C. albicans dual- YOR091w similarity to hypothetical S. pombe protein YDR457w similarity to rat URE-B1 specificity phosphatase MSG5 D83992_G YBR028c similarity to ribosomal protein kinases YLR460c strong similarity to C. carbonum toxD YOL071w similarity to hypothetical S. pombe protein YLR276c similarity to RNA helicases protein SPAC12B10.06c YPR112c similarity to RNA-binding proteins YKL013c strong similarity to C. elegans YFR048w similarity to hypothetical S. pombe protein YPR016c similarity to S. acidocaldarius ao2sac hypothetical protein SPAC12G12.14 and to YDL001w and protein YNL288w strong similarity to C. elegans YDR282c YOL154w similarity to S. fumigata Asp FII hypothetical protein YOR322c similarity to hypothetical S. pombe protein YHR029c similarity to S. lincolnensis lmbX protein YOL077c strong similarity to C. elegans K12H4.3 SPAC1F12.05 YFL033c similarity to S. pombe cek1 protein YOR250c similarity to hypothetical S. pombe protein serine/threonine protein kinase YGL080w strong similarity to C. elegans R07E5.13 SPAC22H10.05c YIL144w similarity to S. pombe hypothetical protein protein YER143w similarity to hypothetical S. pombe protein YKR051w similarity to S. pombe hypothetical protein YPR194c strong similarity to C-term. of S. pombe SPAC56F8.08 YOL087c similarity to S. pombe hypothetical protein isp4 protein YDR504c similarity to hypothetical T. brucei protein YBR004c similarity to S. pombe hypothetical protein YAR023c strong similarity to Fun55p, Fun59p, YDR223w similarity to Ifh1p SPAC18B11.05 YGL051w, YCR007c, YGL053w, YAR031w YAL035w FUN12 similarity to Ifm1p YKR079c similarity to S. pombe hypothetical protein and YAR028w YOR109w similarity to inositol polyphosphate 5- SPAC1D4.10 YAR028w strong similarity to Fun55p, YGL053w, phosphatases YNL308c similarity to S. pombe hypothetical protein YCR007c, YAR031w, Fun59p and YGL051w YEL013w similarity to intracellular attachement SPAC22G7.05 YGL051w strong similarity to Fun59p proteins YAL042w FUN9 similarity to S. pombe hypothetical protein YGL236c strong similarity to gidA E. coli protein YPR042c similarity to Jsn1p SPAC24B11.08c YAL036c FUN11 strong similarity to GTP-binding proteins YMR226c similarity to ketoreductases YNL310c similarity to S. pombe hypothetical protein YMR290c strong similarity to helicases of the YGR232w similarity to L. mactans α-latroinsectotoxin SPAC24H6.02c DEAD/DEAH box family YER010c similarity to L. pneumophila dlpA protein YGR125w similarity to S. pombe hypothetical protein YDR276c strong similarity to Hordeum blt101 protein YGR210c similarity to M. capricolum hypothetical SPAC24H6.11c YDL103c QRI1 strong similarity to human AgX-1 antigen protein SGC3 YMR075w similarity to S. pombe hypothetical protein YDR373w strong similarity to human BDR-1 protein YMR095c similarity to M. leprae hisH protein SPAC2F7.07c and other calcium binding proteins YBR079c similarity to M. musculus p162 protein YDR175c similarity to S. pombe hypothetical protein YNR053c strong similarity to human breast tumor YNL335w similarity to M. verrucaria cyanamide SPAC2F7.15 associated autoantigen hydratase, identical to hypothetical protein YFL047w similarity to S. pombe hypothetical protein YDL120w strong similarity to human frataxin YFL061w SPAC2F7.18c (Friedreichs ataxia) YLL034c similarity to mammalian valosin YLR023c similarity to S. pombe hypothetical protein YGR173w strong similarity to human GTP-binding YMR166c similarity to members of the mitochondrial SPAC30D11.11 protein carrier protein family YDR180w similarity to S. pombe hypothetical protein YKL056c strong similarity to human IgE-dependent YIR041w similarity to members of the Srp1p/Tip1p SPAC31A2.05c histamine-releasing factor family

62 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YPL152w strong similarity to human phosphotyrosyl YDL109c strong similarity to hypothetical protein YGR004w strong similarity to hypothetical protein phosphatase activator YGL144c YLR324w YPR028w strong similarity to human protein TB2 YER037w strong similarity to hypothetical protein YGR010w strong similarity to hypothetical protein YCL059c strong similarity to human Rev interacting YGL224c YLR328w protein Rip-1 YOR387c strong similarity to hypothetical protein YGR038w ORM1 strong similarity to hypothetical protein YLR146c strong similarity to human spermidine YGL258w YLR350w synthase YLR324w strong similarity to hypothetical protein YGR056w strong similarity to hypothetical protein YNL200c strong similarity to human TGR-CL10C YGR004w YLR357w YBL036c strong similarity to hypothetical YLR328w strong similarity to hypothetical protein YKL187c strong similarity to hypothetical protein C. elegans protein YGR010w YLR413w YBL078c strong similarity to hypothetical YLR350w strong similarity to hypothetical protein YPR172w strong similarity to hypothetical protein C. elegans protein YGR038w YLR456w YMR292w strong similarity to hypothetical YLR357w strong similarity to hypothetical protein YDR438w strong similarity to hypothetical protein C. elegans protein YGR056w YML018c YDR430c strong similarity to hypothetical YPL004c strong similarity to hypothetical protein YBR002c strong similarity to hypothetical protein C. perfringens protein YGR086c YMR101c YOR365c strong similarity to hypothetical protein YPR157w strong similarity to hypothetical protein YKL121w strong similarity to hypothetical protein YAL053w YGR141w YMR102c YHR214w-a strong similarity to hypothetical protein YHR162w strong similarity to hypothetical protein YPL224c strong similarity to hypothetical protein YAR068w YGR243w YMR177w YPR032w strong similarity to hypothetical protein YBR300c strong similarity to hypothetical protein YOR295w strong similarity to hypothetical protein YBL106c YGR293c YMR233w YDR003w strong similarity to hypothetical protein YHR054c strong similarity to hypothetical protein YKL046c strong similarity to hypothetical protein YBR005w YHR056c YMR238w YDR210w strong similarity to hypothetical protein YDR358w strong similarity to hypothetical protein YPL264c strong similarity to hypothetical protein YBR016w YHR108w YMR253c YDL012c strong similarity to hypothetical protein YNL116w strong similarity to hypothetical protein YGR279c strong similarity to hypothetical protein YBR016w and YDR210w YHR115c YMR305c YDR018c strong similarity to hypothetical protein YGR238c strong similarity to hypothetical protein YOR385w strong similarity to hypothetical protein YBR042c YHR158c YMR316w YOL092w strong similarity to hypothetical protein YGR243w strong similarity to hypothetical protein YNL034w strong similarity to hypothetical protein YBR147w YHR162w YNL018c YPL095c strong similarity to hypothetical protein YHR199c strong similarity to hypothetical protein YNL033w strong similarity to hypothetical protein YBR177c YHR198c YNL019c YPL087w strong similarity to hypothetical protein YHR198c strong similarity to hypothetical protein YNL019c strong similarity to hypothetical protein YBR183w YHR199c YNL033w YGL056c strong similarity to hypothetical protein YAR060c strong similarity to hypothetical protein YNL018c strong similarity to hypothetical protein YBR214w YHR212c YNL034w YGL060w strong similarity to hypothetical protein YAR068w strong similarity to hypothetical protein YIL109c strong similarity to hypothetical protein YBR216c YHR214w-a YNL049c YGL107c strong similarity to hypothetical protein YPR071w strong similarity to hypothetical protein YOR086c strong similarity to hypothetical protein YBR238c YIL029c YNL087w and weak similarity to YGL101w strong similarity to hypothetical protein YER067w strong similarity to hypothetical protein synaptogamines YBR242w YIL057c YOR092w strong similarity to hypothetical protein YJL058c strong similarity to hypothetical protein YDL175c strong similarity to hypothetical protein YNL095c YBR270c YIL079c YOR110w strong similarity to hypothetical protein YGR293c strong similarity to hypothetical protein YIL014c-a strong similarity to hypothetical protein YNL108c YBR300c YIL102c YHR115c strong similarity to hypothetical protein YDR514c strong similarity to hypothetical protein YNL049c strong similarity to hypothetical protein YNL116w YCL036w YIL109c YDL222c strong similarity to hypothetical protein YGL144c strong similarity to hypothetical protein YOL162w strong similarity to hypothetical protein YNL194c and similarity to YML052w YDL109c YIL166c YLR144c strong similarity to hypothetical protein YIL079c strong similarity to hypothetical protein YJL038c strong similarity to hypothetical protein YNR067c YDL175c YJL037w YDR492w strong similarity to hypothetical protein YNL194c strong similarity to hypothetical protein YJL037w strong similarity to hypothetical protein YOL002c YDL222c and similarity to hypothetical YJL038c YPR125w strong similarity to hypothetical protein protein YML052w YBR270c strong similarity to hypothetical protein YOL027c YBR005w strong similarity to hypothetical protein YJL058c YBR147w strong similarity to hypothetical protein YDR003w YKR018c strong similarity to hypothetical protein YOL092w YBR042c strong similarity to hypothetical protein YJL082w YDR391c strong similarity to hypothetical protein YDR018c YKR021w strong similarity to hypothetical protein YOR013w YLR108c strong similarity to hypothetical protein YJL084c YAL007c strong similarity to hypothetical protein YDR132c YKR053c strong similarity to hypothetical protein YOR016c, similarity to hamster COP- YPL235w strong similarity to hypothetical protein YJL134w coated vesicle membrane protein YDR190c YML047c strong similarity to hypothetical protein YKR089c strong similarity to hypothetical protein YNL281w strong similarity to hypothetical protein YJR054w YOR081c YDR214w YKL200c strong similarity to hypothetical protein YNL095c strong similarity to hypothetical protein YLR225c strong similarity to hypothetical protein YJR061w YOR092w YDR222w YDR399w strong similarity to hypothetical protein YNL108c strong similarity to hypothetical protein YHR032w ERC1 strong similarity to hypothetical protein YJR133w YOR110w YDR338c YMR238w strong similarity to hypothetical protein YLR260w strong similarity to hypothetical protein YHR097c strong similarity to hypothetical protein YKL046c YOR171c YDR348c YMR040w strong similarity to hypothetical protein YLR270w strong similarity to hypothetical protein YHR108w strong similarity to hypothetical protein YKL065c YOR173w YDR358w YMR102c strong similarity to hypothetical protein YLR284c strong similarity to hypothetical protein YOR013w strong similarity to hypothetical protein YKL121w YOR180c YDR391c YLR413w strong similarity to hypothetical protein YLR243w strong similarity to hypothetical protein YJR133w strong similarity to hypothetical protein YKL187c YOR262w YDR399w YJL082w strong similarity to hypothetical protein YMR233w strong similarity to hypothetical protein YOL002c strong similarity to hypothetical protein YKR018c YOR295w YDR492w YJL084c strong similarity to hypothetical protein YGL258w strong similarity to hypothetical protein YOR383c strong similarity to hypothetical protein YKR021w YOR387c YDR534c and similarity to L. mexicana YJL134w strong similarity to hypothetical protein YPL279c strong similarity to hypothetical protein secreted acid phosphatase 2 YKR053c YOR390w YPR193c strong similarity to hypothetical protein YOR081c strong similarity to hypothetical protein YGR086c strong similarity to hypothetical protein YEL066w YKR089c YPL004c YGL224c strong similarity to hypothetical protein YIR013c strong similarity to hypothetical protein YFL004w strong similarity to hypothetical protein YER037w YLR013w YPL019c YIL057c strong similarity to hypothetical protein YLL010c strong similarity to hypothetical protein YBR183w strong similarity to hypothetical protein YER067w YLR019w YPL087w YPL019c strong similarity to hypothetical protein YDR125c strong similarity to hypothetical protein YBR177c strong similarity to hypothetical protein YFL004w YLR099c YPL095c YMR096w strong similarity to hypothetical protein YDR132c strong similarity to hypothetical protein YOR227w strong similarity to hypothetical protein YFL059w, YNL333w, and Para rubber tree YLR108c YPL137c and to microtubule-interacting ethylene-responsive protein 1 YDR185c strong similarity to hypothetical protein protein MHP1 YHR016c YSC84 strong similarity to hypothetical protein YLR168c YGL084c strong similarity to hypothetical protein YFR024c-a YDL161w strong similarity to hypothetical protein YPL189w YBR214w strong similarity to hypothetical protein YLR206w and to human KIAA0171 protein YGL082w strong similarity to hypothetical protein YGL056c YDR222w strong similarity to hypothetical protein YPL191c YBR216c strong similarity to hypothetical protein YLR225c YGL139w strong similarity to hypothetical protein YGL060w YDR213w strong similarity to hypothetical protein YPL221w YPL191c strong similarity to hypothetical protein YLR228c YMR177w strong similarity to hypothetical protein YGL082w YOR171c strong similarity to hypothetical protein YPL224c YPL189w strong similarity to hypothetical protein YLR260w YDR190c strong similarity to hypothetical protein YGL084c YOR173w strong similarity to hypothetical protein YPL235w YBR242w strong similarity to hypothetical protein YLR270w YMR253c strong similarity to hypothetical protein YGL101w YOR180c strong similarity to hypothetical protein YPL264c YLR284c

NATURE | VOL 387 | SUPP | 29 MAY 1997 63 gazetteer

YOR390w strong similarity to hypothetical protein YHL017w strong similarity to putative YLR466w strong similarity to subtelomeric encoded YPL279c transmembrane protein PTM1 proteins YIL029c strong similarity to hypothetical protein YHR017w YSC83 strong similarity to S. douglasii YSD83 YLR467w strong similarity to subtelomeric encoded YPR071w YDL219w strong similarity to S. equisimilis proteins YDL242w strong similarity to hypothetical protein hypothetical protein YML132w strong similarity to subtelomeric encoded YPR079w YPL118w strong similarity to S. kluyveri hypothetical proteins YGR141w strong similarity to hypothetical protein protein YNL336w strong similarity to subtelomeric encoded YPR157w YNR046w strong similarity to S. pombe hypothetical proteins YLR456w strong similarity to hypothetical protein protein SPAC31A2.02 YNL337w strong similarity to subtelomeric encoded YPR172w YNL072w strong similarity to S. pombe hypothetical proteins YEL066w strong similarity to hypothetical protein protein SPAC4G9.02 YNL338w strong similarity to subtelomeric encoded YPR193c YDR032c strong similarity to S. pombe obr1 proteins YGL053w strong similarity to hypothetical proteins YOL010w strong similarity to S. pombe YNL339c strong similarity to subtelomeric encoded YAR031, YGL051w, YAR028w,Fun55p and SPAC12G12.06c protein proteins YCR007c YOR163w strong similarity to S. pombe SPAC13G6.14 YNR077c strong similarity to subtelomeric encoded YMR324c strong similarity to hypothetical proteins protein proteins YBL108w, YCR103c and YKL223w YOR256c strong similarity to secretory protein YOL158c strong similarity to subtelomeric encoded YNR048w strong similarity to hypothetical proteins SSP134 proteins YCR094w and YNL323w YCL024w strong similarity to ser/thr protein kinase YPL282c strong similarity to subtelomeric encoded YNL323w strong similarity to hypothetical proteins GNP1 proteins YCR094w and YNR048w YOR310c strong similarity to SIK1 protein YPL283c strong similarity to subtelomeric encoded YBR016w strong similarity to hypothetical proteins YDR247w strong similarity to Sks1p proteins YDL012c and YDR210w O7535 strong similarity to subtelomeric encoded YPR202w strong similarity to subtelomeric encoded YNL334c strong similarity to hypothetical proteins proteins proteins YFL060c and YMR095c YAL068c strong similarity to subtelomeric encoded YPR203w strong similarity to subtelomeric encoded YPL221w strong similarity to hypothetical proteins proteins proteins YGL139w and YAL053w YBL108w strong similarity to subtelomeric encoded YPR204w strong similarity to subtelomeric encoded YDR326c strong similarity to hypothetical proteins proteins proteins YHR080c, YFL042c and YLR072w YBL111c strong similarity to subtelomeric encoded YNR075w EDL1 strong similarity to subtelomeric encoded YMR251w strong similarity to hypothetical proteins proteins proteins YKR076w and YGR154c YBL112c strong similarity to subtelomeric encoded YER042w strong similarity to transcription factors YGR154c strong similarity to hypothetical proteins proteins and peptide methionine sulphoxide YKR076w and YMR251w YBL113c strong similarity to subtelomeric encoded reductases YKR076w strong similarity to hypothetical proteins proteins YJL186w strong similarity to Ttp1p YMR251w and YGR154c YBR302c strong similarity to subtelomeric encoded YEL041w strong similarity to Utr1p YFL060c strong similarity to hypothetical proteins proteins YCR063w strong similarity to Xenopus G10 and YNL334c and YMR095c YCL073c strong similarity to subtelomeric encoded human edg-2 protein YCR094w strong similarity to hypothetical proteins proteins YAR027w FUN55 strong similarity to YAR028w, YCR007c, YNR048w and YNL323w YCR103c strong similarity to subtelomeric encoded YGL053w, YAR031w, FUN59p and YOR230w strong similarity to hypothetical proteins proteins YGL051w YOR229w and YPL139c YDL248w strong similarity to subtelomeric encoded YAR029w FUN57 strong similarity to YAR031w, YGL053w, YPL139c strong similarity to hypothetical proteins proteins Fun55p, Fun59p and YGL051w YOR230w and YOR229w YDR542w strong similarity to subtelomeric encoded YAR033w FUN59 strong similarity to YGL051w, YGL053w, YOR229w strong similarity to hypothetical proteins proteins YAR031w, Fun55p, YAR028w and YOR230w and YPL139c YDR543c strong similarity to subtelomeric encoded YCR007c YAL053w strong similarity to hypothetical proteins proteins YAR031w strong similarity to YGL053w, Fun59p, YOR365c,YGL139w,YPL221w YDR544c strong similarity to subtelomeric encoded YGL051w, Fun55p, YAR028w and YPL280w strong similarity to hypothetical proteins proteins YCR007c YOR391c, YMR322c and YDR533c YDR545w strong similarity to subtelomeric encoded YIL102c strong similarity to YIL014c-a YMR321c strong similarity to hypothetical proteins proteins YBR025c strong similarity to Ylf1p YPL273w and YLL062c YEL075c strong similarity to subtelomeric encoded YKL065c strong similarity to YMR040w YLL062c strong similarity to hypothetical proteins proteins YOL112w strong similarity to YNL293w, similarity to YPL273w, weak similarity to M. leprae YEL076c-b strong similarity to subtelomeric encoded Mic1p and human transforming protein metH2 protein proteins tre-2 YOR391c strong similarity to hypothetical proteins YER188c-a strong similarity to subtelomeric encoded YBL106c strong similarity to YPR032w YPL280w, YMR322c and YDR533c proteins YLR045c STU2 suppressor of a cs tubulin mutation YDR533c strong similarity to hypothetical proteins YER189w strong similarity to subtelomeric encoded YER120w SCS2 suppressor of an inositol auxotrophic and YPL280w, YOR391c and YMR322c proteins a choline sensitive mutant YMR322c strong similarity to hypothetical proteins YER190w strong similarity to subtelomeric encoded YCR044c suppressor of cdc1-1 ts growth defect YPL280w, YOR391c and YDR533c proteins YGL083w SCY1 suppressor of GTPase mutant YHR069c strong similarity to hypothetical S. pombe YFL062w strong similarity to subtelomeric encoded YDR510w SMT3 suppressor of mif2 temperature-sensitive and human proteins proteins mutation YMR288w strong similarity to hypothetical S. pombe YFL063w strong similarity to subtelomeric encoded YKL124w SSH4 suppressor of shr3 protein proteins YLR197w SIK1 suppressor of toxicity of Gal4-IKB YER049w strong similarity to hypothetical S. pombe YFL064c strong similarity to subtelomeric encoded YOL102c TPT1 tRNA 2’-phosphotransferase protein YER049W proteins YIL080w Ty3-2 orf C fragment YNL240c strong similarity to K. marxianus LET1 YFL065c strong similarity to subtelomeric encoded YBR015c TTP1 type II membrane protein protein proteins YBR066c weak similarity to A. niger carbon YBR301w strong similarity to members of the YFL066c strong similarity to subtelomeric encoded catabolite repressor protein Srp1p/Tip1p family proteins YKL071w weak similarity to A. parasiticus nor-1 YGL261c strong similarity to members of the YGL260w strong similarity to subtelomeric encoded protein Srp1p/Tip1p family proteins YJL126w weak similarity to A. thaliana nitrilase 3 YGR294w strong similarity to members of the YGR295c strong similarity to subtelomeric encoded YCR079w weak similarity to A. thaliana protein Srp1p/Tip1p family proteins phosphatase 2C YIL176c strong similarity to members of the YGR296w strong similarity to subtelomeric encoded YHR143w weak similarity to a-agglutinin core protein Srp1p/Tip1p family proteins AGA1 YKL224c strong similarity to members of the YHL045w strong similarity to subtelomeric encoded YOR353c weak similarity to adenylate cyclases Srp1p/Tip1p family proteins YER158c weak similarity to Afr1p YLL025w strong similarity to members of the YHL048w strong similarity to subtelomeric encoded YBR074w weak similarity to aminopeptidase Y Srp1p/Tip1p family proteins YCR051w weak similarity to ankyrins YLL064c strong similarity to members of the YHR217c strong similarity to subtelomeric encoded YNR039c weak similarity to Anopheles Srp1p/Tip1p family proteins mitochondrial NADH dehydrogenase YLR037c strong similarity to members of the YHR218w-a strong similarity to subtelomeric encoded subunit 2 Srp1p/Tip1p family proteins YMR152w weak similarity to AST1 and AST2 protein YMR325w strong similarity to members of the YIR040c strong similarity to subtelomeric encoded YJL109c weak similarity to ATPase Drs2p Srp1p/Tip1p family proteins YIR002c weak similarity to ATP-dependent RNA YOR394w strong similarity to members of the YJL225c strong similarity to subtelomeric encoded helicases Srp1p/Tip1p family proteins YMR211w weak similarity to β tubulins YEL047c strong similarity to Osm1p YJR161c strong similarity to subtelomeric encoded YEL040w UTR2 weak similarity to B. subtilis 1,3-1,4-— YFL059w strong similarity to Para rubber tree proteins glucanase ethylene-responsive protein1 YJR162c strong similarity to subtelomeric encoded YNL203c weak similarity to B. subtilis YNL333w strong similarity to Para rubber tree proteins CDPdiacylglycerol-serine ethylene-responsive protein 1 and YKL223w strong similarity to subtelomeric encoded O-phosphatidyltransferase identical to hypothetical protein YFL059w proteins YDR336w weak similarity to B. subtilis hypothetical YNR065c strong similarity to Pep1p YKL225w strong similarity to subtelomeric encoded protein X YNR066c strong similarity to Pep1p proteins YOR111w weak similarity to B. subtilis maf protein YER089c PTC2 strong similarity to phosphoprotein YKR106w strong similarity to subtelomeric encoded YNR074c weak similarity to B. subtilis nitrite phosphatases proteins reductase (nirB) YPL141c strong similarity to protein kinase Kin4p YLL066c strong similarity to subtelomeric encoded YNR004w weak similarity to bovine interferon γ YOL128c strong similarity to protein kinase Mck1p proteins YNL022c weak similarity to C. burnetii FMU protein YNL020c strong similarity to protein kinase PAK1 YLL067c strong similarity to subtelomeric encoded YGL246c weak similarity to C. elegans dom-3 YJR150c strong similarity to proteins of the proteins protein Srp1p/Tip1p family YLR462w strong similarity to subtelomeric encoded YKR071c weak similarity to C. elegans hypothetical YDL214c strong similarity to putative protein kinase proteins protein NPR1 YLR463c strong similarity to subtelomeric encoded YNL207w weak similarity to C. elegans hypothetical YEL077c strong similarity to putative purine proteins protein ZK632.3 nucleotide-binding protein YIL177c YLR464w strong similarity to subtelomeric encoded YLR242c weak similarity to C. elegans R05H5.5 proteins protein and T. borreli apocytochrome b

64 NATURE | VOL 387 | SUPP | 29 MAY 1997 gazetteer

YKL037w weak similarity to C. elegans ubc-2 YNR061c weak similarity to hypothetical protein YNR022c weak similarity to protein phosphatases protein YDL218w YBR276c weak similarity to protein-tyrosine- YHR012w PEP11 weak similarity to C. elegans Z47357_A YOR004w weak similarity to hypothetical protein phosphatase ZK1128.1 YDR339c YMR241w weak similarity to putative carrier protein YJR024c weak similarity to C. elegans Z49131_E YMR010w weak similarity to hypothetical protein RIM2 ZC373.5 protein YDR352w YJR044c weak similarity to putative transport YBR086c weak similarity to calcium and sodium YGR223c weak similarity to hypothetical protein protein YKR103w channel proteins YFR021w YBR103w weak similarity to Pwp2p YGR225w weak similarity to Cdc20p YGR095c weak similarity to hypothetical protein YMR093w weak similarity to Pwp2p YNR051c weak similarity to chicken nucleolin YGR195w YNR064c weak similarity to R. capsulatus bchO YMR272c weak similarity to cytochrome b5 YHR160c weak similarity to hypothetical protein protein YEL045c weak similarity to cytochrome c oxidase YGR239c YEL018w weak similarity to Rad50p III of T. brucei kinetoplast YGR239c weak similarity to hypothetical protein YGL244w weak similarity to Rad50p YHR142w weak similarity to cytochrome c oxidases YHR160c YHR022c weak similarity to RAS-related protein YDL035c weak similarity to D. discoideum protein YMR299c weak similarity to hypothetical protein YLR351c weak similarity to rat β-alanine synthase tyrosine phosphatase YJL062w YCR082w weak similarity to Rbk1p YGL242c weak similarity to D. melanogaster ANK YKL041w weak similarity to hypothetical protein YOR246c weak similarity to reductases protein YKL002w YJL012c weak similarity to regulatory protein YPR200c weak similarity to D. melanogaster cdc25 YMR124w weak similarity to hypothetical protein PHO81 protein, and similarity to hypothetical YLR031w YDL114w weak similarity to Rhizobium nodulation protein YGR203w YPL109c weak similarity to hypothetical protein protein nodG YHL041w weak similarity to D. melanogaster YLR253w YGR068c weak similarity to Rod1p hypothetical protein 6 YBR168w weak similarity to hypothetical protein YKL107w weak similarity to S. antibioticus probable YOR022c weak similarity to D. melanogaster YLR324w oxidoreductase probable Ca2+ transporter rdgB YNR014w weak similarity to hypothetical protein YER093c weak similarity to S. epidermidis PepB YPL229w weak similarity to D. melanogaster YMR206w protein transcription factor shn YER186c weak similarity to hypothetical protein YMR065w weak similarity to S. pombe hypothetical YGL185c weak similarity to dehydrogenases YMR316w protein SPAC13C5.03 YLR222c weak similarity to Dip2p YJR129c weak similarity to hypothetical protein YGR212w weak similarity to S. pombe hypothetical YER041w weak similarity to DNA repair protein YNL024c protein SPAC18B11.03c Rad2p YJL016w weak similarity to hypothetical protein YER127w weak similarity to S. pombe hypothetical YOR032c weak similarity to DNA-binding proteins YNL278w and YLR187w protein SPAC18B11.06 YJL162c weak similarity to dnaJ proteins YMR206w weak similarity to hypothetical protein YBR271w weak similarity to S. pombe uvi22 protein YBR220c weak similarity to E. coli ampG protein YNR014w and hypothetical protein YNL024c YNL217w weak similarity to E. coli bis(5’-nucleosyl)- YDL218w weak similarity to hypothetical protein YLR311c weak similarity to S. tarentolae tetraphosphatase YNR061c cryptogene protein G4 YER126c weak similarity to E. coli colicin N YDR339c weak similarity to hypothetical protein YLR380w weak similarity to Sec14p YGL136c weak similarity to E. coli ftsJ protein YOR004w YNL231c weak similarity to Sec14p YKL094w YJU3 weak similarity to E. coli hypothetical YLR253w weak similarity to hypothetical protein YJL123c weak similarity to Sec7p protein YPL109c YKL055c weak similarity to short-chain alcohol YMR155w weak similarity to E. coli hypothetical YPR151c weak similarity to hypothetical protein dehydrogenases protein f402 YPL159c YNR030w weak similarity to Smp3p YER152c weak similarity to E. coli hypothetical YPL159c weak similarity to hypothetical protein YDR486c weak similarity to Snf7p protein f470 YPR151c YEL015w weak similarity to Spa2p YJR019c weak similarity to E. coli thioesterase II YGR126w weak similarity to hypothetical protein YHR177w weak similarity to Spombe pac2 protein YPR067w weak similarity to F. alni nitrogen fixation YPR156c YBR155w weak similarity to stress-induced Sti1p protein YLR391w weak similarity to hypothetical proteins YJR101w weak similarity to superoxide dismutases YDR063w weak similarity to glia maturation factor β YAR068w and YHR214w-a YBR099c weak similarity to T. brucei mitochondrion YCL028w weak similarity to glutenins, high YNL024c weak similarity to hypothetical proteins hypothetical protein 6 molecular weight subunit YBR271w and YJR129c YJL145w weak similarity to T. pacificus retinal- YPL206c weak similarity to glycerophosphoryl YAL018c weak similarity to hypothetical proteins binding protein diester phosphodiesterases YOL047c and YOL048c YJL204c weak similarity to Tor2p YOR272w weak similarity to GTP-binding protein β YDR352w weak similarity to hypothetical proteins YER045c weak similarity to transcription factor subunits YOL092w, YBR147w and YMR010w Sko1p YAL048c weak similarity to GTP-binding proteins YDR517w weak similarity to hypothetical S. pombe YDR520c weak similarity to transcription factors YBR175w weak similarity to GTP-binding proteins protein YHR063c weak similarity to translational activator YPL093w weak similarity to GTP-binding proteins YCR013c weak similarity to M. leprae B1496_F1_41 CBS2 YGL067w weak similarity to H. influenzae protein YGL004c weak similarity to Tup1p hypothetical protein YPL273w weak similarity to M. leprae metH2 YJR046w weak similarity to Xenopus vimentin 4 YLR165c weak similarity to H. influenzae protein, and strong similarity to YOL031c weak similarity to Y. lipolytica Sls1 protein hypothetical protein HI0176 hypothetical protein YLL062c YLL056c weak similarity to Y. pseudotuberculosis YLR239c weak similarity to H. influenzae lipoate YEL043w weak similarity to Mad1p CDP-3,6-dideoxy-D-glycero-L-glycero-4- biosynthesis protein B YBR186w weak similarity to members of hexulose-5-epimerase YNR062c weak similarity to H. influenzae L-lactate CDC48/PAS1/SEC18 family of ATPases YCL063w weak similarity to yeast translation permease (lctP) homologue YFL046w weak similarity to middle part of C. regulator Gcd6p YNL176c weak similarity to Hkr1p elegans myosin heavy chain A YGR110w weak similarity to YLR099c and YDR125c YBL032w weak similarity to hnRNP complex protein YOR350c MNE1 weak similarity to mitochondrial L. illustris YDR090c weak similarity to Yro2p homologue YBR233w cytochrome oxidase I YIL044c weak similarity to zinc-finger protein GCS1 YER033c weak similarity to human BRCA2 early YMR111c weak similarity to MSN1 protein YLR040c weak similartity to hypothetical protein onset breast cancer gene YMR172w weak similarity to MSN1 protein YIL011w YIL036w weak similarity to human cAMP responce YDL223c weak similarity to mucin YNL212w weak simlarity to C. cardunculus cypro4 element-binding protein YJL036w weak similarity to Mvp1p protein YJL148w weak similarity to human chromatin YNL063w weak similarity to Mycoplasma assembly factor I protoporphyrinogen oxidase YDR030c weak similarity to human CSA protein YLR309c IMH1 weak similarity to myosin heavy chains YGL243w weak similarity to human double-stranded YBR156c weak similarity to myosins RNA adenosine deaminase YAL022c FUN26 weak similarity to Na+/H+ antiporter YJL091c weak similarity to human G protein- YDR413c weak similarity to NADH dehydrogenase coupled receptor YKR030w weak similarity to NADH dehydrogenases YER063w weak similarity to human heterogeneous YPR174c weak similarity to Nbp1p ribonuclear particle protein U YKR075c weak similarity to negative regulator YJR002w weak similarity to human kinesin-related Srn1p/Hex2p protein CENP-E YCR047c weak similarity to N-methyltransferases YMR029c weak similarity to human nuclear YJL131c weak similarity to non-epidermal Xenopus autoantigen keratin, type I YCL045c weak similarity to human ORF YHL024w weak similarity to nuclear protein NOP4 YJL057c weak similarity to human P1/eIF-2a YLR126c weak similarity to P. aeruginosa protein kinase anthranilate synthase component II YNR008w weak similarity to human YHL021c weak similarity to P. aeruginosa phosphatidylcholine-sterol γ-butyrobetaine hydroxylase O-acyltransferase YMR009w weak similarity to P. aeruginosa YJL132w weak similarity to human phospholipase regulatory protein mmsR D YGR276c weak similarity to P. troglodytes GOR YLL037w weak similarity to human platelet- protein activating factor receptor YER059w weak similarity to Pho80p YHR090c weak similarity to human retinoblastoma YOR281c weak similarity to phosducins binding protein 2 YMR221c weak similarity to photosystem II protein YOR064c weak similarity to human retinoblastoma D2 binding protein 2 YBR094w weak similarity to pig tubulin-tyrosine YMR131c weak similarity to human retinoblastoma- ligase binding protein YOR287c weak similarity to PITSLRE protein kinase YLR272c weak similarity to hypothetical human isoforms ORF YBR151w weak similarity to potato sucrose YDL111c weak similarity to hypothetical human cleavage protein protein YML050w weak similarity to potato sucrose YCR059c weak similarity to hypothetical protein cleavage protein YDL177c YGR262c weak similarity to protein kinases YPR106w weak similarity to protein kinases

NATURE | VOL 387 | SUPP | 29 MAY 1997 65