An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000238675-HmpCyc: Bacillus smithii 7_3_47FAA Cellular Overview Connections between pathways are omitted for legibility.

ammonium sn-glycerol phosphate phosphate phosphate lactose 3-phosphate

cis-vaccenate cis-vaccenate ammonium ammonium a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid predicted predicted PEP-driven ABC RS10285 RS15775 RS10355 RS01615 RS10760 RS13160 RS03265 RS05595 RS05325 RS13065 RS06395 RS16415 RS03215 RS15020 RS00595 RS07180 RS07100 RS03715 RS11020 RS01730 RS11015 RS10260 RS09395 RS05305 RS08100 RS01150 RS11450 RS16105 RS12775 RS07780 RS07770 RS07740 RS09765 RS06500 RS14755 RS06240 RS06235 RS01480 RS12485 RS12770 RS13515 RS14745 RS14130 RS03565 RS09215 RS09225 RS09245 RS06010 RS01675 RS03430 RS09280 RS11060 RS15180 RS01630 RS07890 RS12575 RS13635 RS12440 RS11180 RS05215 RS15045 RS12080 RS16225 RS10305 RS02210 RS16515 RS07295 RS10890 RS04210 RS04160 RS05245 RS12100 RS00210 RS03065 RS05480 RS08905 RS08965 RS15345 RS14910 RS12125 RS09190 RS02525 RS10135 RS09185 RS17455 RS09180 RS16395 RS08385 RS02975 RS00010 RS08365 RS08360 RS08355 RS09165 RS09160 RS02405 RS09155 RS10320 RS08265 RS09140 RS06195 transporter transporter of lactose of phosphate RS09975 RS01355 ammonium cis-vaccenoyl-CoA cis-vaccenoyl-CoA phosphate ammonium ammonium sn-glycerol a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA phosphate lactose 6'- 3-phosphate phosphate phosphate RS06440 RS15340

RS15395 RS01710 RS13385 Nucleoside and Nucleotide Biosynthesis Metabolic Regulator Macromolecule Modification tRNA processing a (2R)-2-hydroxy an odd numbered α ω 1-myristoyl- superpathway of guanosine , -9Z- 1-(18-hydroxyoleoyl)- 1-cis-vaccenoyl-sn- a ribonucleoside DNA combined RS04230 UMP biosynthesis III inosine-5'-phosphate biosynthesis I superpathway of 5-aminoimidazole ribonucleotide biosynthesis I superpathway of pyrimidine Biosynthesis Fatty Acid and Lipid Degradation even numbered straight chain a peptide with a sn-glycerol NMN RS09545 nucleotides de novo biosynthesis I pyrimidine deoxyribonucleotides de novo biosynthesis I octadecenedioate sn-glycrol 3-phosphate glycerol-3-phosphate diphosphate with exogenous AMP adenosine nucleotides nucleobases salvage a polycistronic leader sequence RS03990 ppGpp biosynthesis straight chain 2,3,4- 2,3,4-saturated long-chain-fatty- signal peptidase I: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- ribonucleotide- 3-phosphate 1-acyl-sn-glycerol-3- DNA to form a bifunctional de novo biosynthesis I tRNA precursor long-chain fatty long-chain fatty bifunctional UDP CTP uracil fatty acid β-oxidation I saturated fatty acid fatty acid acid--CoA ligase: HMPREF1015_RS01300 phosphate acyltransferase: phosphate acyltransferase: diphosphate reductase: recombinational metallophosphatase/ gln hydrogencarbonate AIR PRPP acid--CoA ligase: acid--CoA ligase: phosphate acyltransferase: Holliday junction metallophosphatase/ IMP superpathway of pyrimidine deoxyribonucleoside salvage ribonucleotide- nucleoside HMPREF1015_RS11060 signal peptidase I: HMPREF1015_RS13350 HMPREF1015_RS13350 HMPREF1015_RS08125 HMPREF1015_RS13350 junction resolvase RecU: 5'-nucleotidase: RS00995 5-(carboxyamino)imidazole bifunctional pyr operon pppGpp HMPREF1015_RS15180 HMPREF1015_RS15180 5'-nucleotidase: asp IMP amidophosphoribosyltransferase: diphosphate reductase: triphosphatase YtkD: GTP pyrophosphokinase: a (3Z)-alk-3- long-chain fatty HMPREF1015_RS08130 HMPREF1015_RS14080 RS09590 carbamoyl- ribonucleotide synthase: transcriptional regulator/uracil HMPREF1015_RS10620 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- HMPREF1015_RS13060 HMPREF1015_RS01000 2'-deoxycytidine HMPREF1015_RS08125 HMPREF1015_RS02120 enoyl-CoA long-chain-fatty- long-chain-fatty- acid--CoA ligase: bifunctional RS05125 IMP dehydrogenase: phosphate synthase: HMPREF1015_RS07930 adenylosuccinate synthase: HMPREF1015_RS07960 phosphoribosyltransferase HMPREF1015_RS06085 a leader sequence a peptide phosphate acyltransferase: phosphate acyltransferase: ribonucleoside- phosphate acyltransferase: Holliday junction HMPREF1015_RS08130 CDP a tRNA precursor long-chain-fatty- acid--CoA ligase: acid--CoA ligase: HMPREF1015_RS15180 metallophosphatase/ [+ 2 isozymes] HMPREF1015_RS10405 N5-CAIR HMPREF1015_RS05180 5-phospho-β- PyrR: HMPREF1015_RS10390 bifunctional (p)ppGpp exoribonuclease: HMPREF1015_RS07550 HMPREF1015_RS07550 diphosphate reductase, HMPREF1015_RS07550 resolvase RuvX: HMPREF1015_RS00070 adenylo-succinate cytidine deaminase: 2'-deoxycytidine kinase: gly acid--CoA ligase: a HMPREF1015_RS11060(R)-2-hydroxy even HMPREF1015_RS11060an odd numbered ω-carboxy- 1-[18-hydroxyoeoyl]-2- 1-cis-vaccenoyl- 1-myristoyl-2- resolution of adenosine [+ 2 isozymes] ribonucleoside- synthetase/guanosine- with a 5' extension 5'-nucleotidase: RS14955 HMPREF1015_RS10410 HMPREF1015_RS02285 HMPREF1015_RS05275 D-ribosylamine uracil HMPREF1015_RS05470 numbered straight straight chain [18-hydroxy-lioleoyl]-sn 2-palmitoleoyl-sn- adenosylcobalamin- palmitoleoyl- recombinationalHMPREF1015_RS14625 5-(carboxyamino)imidazole dUDP diphosphate reductase, guanosine 3'-diphosphate and a long 3' trailer a tRNA precursor with HMPREF1015_RS11060 diphosphate AMP diphosphate AMP AMP diphosphate (9Z)-octadec- HMPREF1015_RS01000 adenylosuccinate lyase: phosphoribosyltransferase: 3',5'-bis(diphosphate) 3'- a 2,3,4-saturated a (2E)-2- chain 2,3,4-saturated 2,3,4-saturated -glycerol 3-phosphate glycerol-3-phosphate dependent: sn-glycerol junction 1-(β-D XMP carbamoyl ribonucleotide mutase: adenosylcobalamin- 5'-triphosphate 3'- a 5' extension and coenzyme A long-chain fatty 9-enoyl-CoA asp HMPREF1015_RS07935 2'-deoxyuridine dCMP phosphoribosylamine- nucleoside- HMPREF1015_RS04720 pyrophosphohydrolase: fatty acid enoyl-CoA fatty acyl CoA fatty acyl CoA a 2'- HMPREF1015_RS14000 3-phosphate formation of two ribofuranosyl) RS13950 phosphate HMPREF1015_RS07925 dependent: diphosphatase: a short 3' extension acid--CoA ligase: -glycine ligase: diphosphate kinase: UMP HMPREF1015_RS14730 RNase BN ribonuclease:ribonuclease PH: deoxyribonucleoside intact strands nicotinamide xanthosine-5'-phosphate:L- (d)CMP kinase: HMPREF1015_RS14000 HMPREF1015_RS14730 ribonuclease P HMPREF1015_RS15180 aspartate CAIR thymidine kinase: HMPREF1015_RS07980 HMPREF1015_RS13235 HMPREF1015_RS05470HMPREF1015_RS15085 acyl-CoA dehydrogenase: a 2,3,4- 5'-diphosphate RS14460 glutamine amido- AMP HMPREF1015_RS13355 UMP kinase: protein component: carbamoyltransferase HMPREF1015_RS04800 dUTP ribonucleotide- HMPREF1015_RS10865 HMPREF1015_RS05080 HMPREF1015_RS01200 saturated (3R)-3- ligase (AMP-forming): [+ 5 isozymes] catalytic subunit: phosphoribosylaminoimidazolesuccinocarboxamide deoxynucleoside kinase: dCDP diphosphate reductase: a 2,3,4- hydroxyacyl-CoA RS05655 HMPREF1015_RS07885 thymidine GAR (d)CMP kinase: a tRNA precursor with acetone degradation a 2,3,4-saturated undecaprenyl- 1-stearoyl- a (7Z,10Z,13Z,16Z 1-cis-vaccenoyl- a 1-alkyl-sn 1-palmitoyl- a uracil 1939 a [lipoyl-carrier HMPREF1015_RS10395 synthase: HMPREF1015_RS07940 adenylate kinase: HMPREF1015_RS08125 a tRNA precursor saturated (3S)-3- decanoate HMPREF1015_RS05275 nucleoside- HMPREF1015_RS13355 II (to acetoacetate) fatty acyl CoA diphospho-N- a palmitoyl-[acp] sn-glycerol ,19Z)-3-oxodocosa- sn-glycerol- -glycerol 3- sn-glycerol protein]-N 6 -[(R) a short 3' extension hydroxyacyl-CoA ATP H O in 23S rRNA IMP RS01790 HMPREF1015_RS11495 phosphoribosylglycinamide HMPREF1015_RS08130 GTP ppGpp with a 5' extension 2 GMP N-carbamoyl- SAICAR thymidine kinase: diphosphate kinase: 3-hydroxyacyl-CoA acetylmuramoyl- UDP-N-acetyl- 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty 7,10,13,16,19-pentaenoyl-[acp]3-oxoacyl-ACP 3-phosphate phosphate 3-phosphate 23S rRNA -dihydrolipoyl]- formyltransferase: dUMP UDP ATPase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- L-aspartate dUMP HMPREF1015_RS04800 HMPREF1015_RS13235 dCDP propan-2-ol dehydrogenase: L-alanyl-γ-D- α-D-glucosamine phosphate acyltransferase: acid--CoA ligase: reductase FabG: (uracil(1939)-C(5))- L-lysine dihydrolipoyl bifunctional HMPREF1015_RS07970 nucleoside- ribonuclease PH: HMPREF1015_RS00865 phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: adenylosuccinate lyase: ADP deoxynucleoside kinase: thymidylate synthase: adenine salvage ribonuclease: HMPREF1015_RS04890 glutamyl-L-lysyl- undecaprenyldiphospho- HMPREF1015_RS13350 HMPREF1015_RS15180 HMPREF1015_RS02605 methyltransferase RlmD: dehydrogenase: metallophosphatase/ RS14465 dihydroorotase: dCTP nucleoside- diphosphate kinase: HMPREF1015_RS15085 HMPREF1015_RS13350 HMPREF1015_RS07550 HMPREF1015_RS13350 guanylate kinase: HMPREF1015_RS07935 thymidylate synthase: HMPREF1015_RS05275 HMPREF1015_RS12270 nucleoside- HMPREF1015_RS05080 D-alanyl-D-alanine muramoylpentapeptide beta-N- nucleoside HMPREF1015_RS11305 5'-nucleotidase: HMPREF1015_RS10400 FGAR diphosphate kinase: a 2,3,4-saturated a 2,3,4-saturated ditrans,octacis- 1-acyl-sn-glycerol-3- long-chain-fatty- a (3R,7Z,10Z,13[+Z,16 4 isozymes]Z 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- HMPREF1015_RS13830 RS08920 HMPREF1015_RS10455 HMPREF1015_RS12270 HMPREF1015_RS13235 diphosphate kinase: acetylglucosaminyltransferase: triphosphatase YtkD: HMPREF1015_RS01000 ribonucleotide- dTMP HMPREF1015_RS13235 acetone fatty acyl CoA 3-oxoacyl-CoA undecaprenyldiphospho- phosphate acyltransferase: acid--CoA ligase: ,19Z)-3-hydroxydocosa- phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: 23S rRNA dihydrolipoyl AICAR phosphoribosylformylglycinamidine HMPREF1015_RS13235 GTP pyrophosphokinase: HMPREF1015_RS10300 HMPREF1015_RS02120 [+ 2 isozymes] (S)-dihydroorotate diphosphate reductase: UTP adenine β HMPREF1015_RS07550 HMPREF1015_RS11060 (uracil(1939)-C(5))- dehydrogenase: dTMP kinase: dCTP N-acetyl-(N-acetyl- -D- 1-stearoyl- 7,10,13,16,19-pentaenoyl-[acp] + 1,2-dicis- HMPREF1015_RS07550 a 2-acyl-1-alkyl-HMPREF1015_RS13350 1-palmitoyl-2- HMPREF1015_RS07550 HMPREF1015_RS08125 synthase: HMPREF1015_RS07945 HMPREF1015_RS06085 bifunctional (p)ppGpp acetone carboxylase: UDP H phosphate ADP methyltransferase RlmD: a [lipoyl-carrier inosine GDP bifunctional HMPREF1015_RS00410 CTP synthase: glucosaminyl)muramoyl- vaccenoyl- sn-glycerol HMPREF1015_RS09970 RS08995 purine deoxyribonucleosides salvage HMPREF1015_RS07950 synthetase/guanosine- NADH repair HMPREF1015_RS04390 2-palmitoyl- diphosphate AMP decanoyl-CoA palmitoleoyl- 6 dihydroorotate phosphoribosylaminoimidazolecarboxamide HMPREF1015_RS08130 HMPREF1015_RS04850 an uncharged tRNA L-alanyl-γ-D-glutamyl-L- acyl-carrier protein HMPREF1015_RS08175 protein]-N - RS03075 HMPREF1015_RS07955 dTDP 3',5'-bis(diphosphate) 3'- HMPREF1015_RS04395 acetyl-CoA C- sn-glycerol phosphatidate 3-phosphate sn-glycerol a 5- dehydrogenase [+ 2 isozymes] adenine deaminase: adenine 1939 lipoyl-L-lysine formyltransferase/IMP cyclohydrolase CTP pyrophosphohydrolase: acyltransferase: lysyl-D-alanyl-D-alanine 3-phosphate 3-phosphate methyluracil nucleoside- electron transfer subunit: PurH: HMPREF1015_RS07975 nucleoside- HMPREF1015_RS01350 phosphoribosyltransferase: NADH acetoacetate ribonucleotide- dTMP 2'-deoxyguanosine 2'-deoxyadenosine FGAM HMPREF1015_RS14730 acetyl-CoAHMPREF1015_RS04895 in 23S rRNA diphosphate kinase: HMPREF1015_RS10415 dADP diphosphate kinase: HMPREF1015_RS14735 diphosphate reductase: [+ 2 isozymes] RS08970 HMPREF1015_RS13235 HMPREF1015_RS08125 PRPP FAICAR dTMP kinase: deoxynucleoside kinase: deoxynucleoside kinase: phosphoribosylformylglycinamidine HMPREF1015_RS13235 GDP RS04665 orotate HMPREF1015_RS00410 1-stearoyl- 1-myristoyl- a 1-acyl-sn an [apo BCAA HMPREF1015_RS08130 nucleoside- HMPREF1015_RS05275 HMPREF1015_RS05275 cyclo-ligase: HMPREF1015_RS07965 dTTP guanine and hypoxanthine queuosine biosynthesis salicyl-6-hydroxy-2- a 3-oxohexacosanoyl- a [protein]-L- bifunctional 16-hydroxypalmitate a stearoyl-[acp] sn-glycerol octanoate a [protein] Ser/Thr sn-glycerol -glycerol 3- dehydrogenase met [+ 2 isozymes] diphosphate kinase: dTDP guanosine salvage II AMP cyclohexene-on-oyl [acp] methionine orotate phosphoribosylaminoimidazolecarboxamide dGMP dAMP long-chain fatty 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty carboxylesterase: serine/threonine 3-oxoacyl-ACP 3-phosphate phosphate E2 protein] N 6 peptide-methionine GTP HMPREF1015_RS13235 AIR hypoxanthine preQ (R)-NADHX 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- bifunctional glutamate phosphoribosyltransferase: formyltransferase/IMP cyclohydrolase nucleoside- 0 acid--CoA ligase: acid--CoA ligase: HMPREF1015_RS08680 protein kinase: (S)-S-oxide reductase: phosphoribosyltransferase: phosphate acyltransferase: reductase FabG: phosphate acyltransferase: phosphate acyltransferase: -dihydrolipoyl- N-acetyltransferase/ RS08945 HMPREF1015_RS10430 PurH: HMPREF1015_RS07975 diphosphate kinase: NADPH-dependent 7- bifunctional ADP-dependent HMPREF1015_RS15180 HMPREF1015_RS15180 HMPREF1015_RS10500 dihydrolipoyl HMPREF1015_RS02320 RS00245 dATP guanine and guanosine HMPREF1015_RS00200 Cell Structure Biosynthesis HMPREF1015_RS13350 carboxylesterase: HMPREF1015_RS02605 HMPREF1015_RS13350 HMPREF1015_RS13350 L-lysine amino-acid dGDP HMPREF1015_RS13235 cyano-7-deazaguanine NAD(P)H-hydrate long-chain-fatty- long-chain-fatty- HMPREF1015_RS05475 HPr kinase/phosphorylase: dehydrogenase: peptide-methionine guanosine salvage xanthine 1-acyl-sn-glycerol-3- 6-hydroxy-2- a (3R)-3-[+ 4 isozymes] 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- acetyltransferase ArgJ: orotidine 5'- reductase QueF: dehydratase/NAD(P) acid--CoA ligase: acid--CoA ligase: HMPREF1015_RS05665 HMPREF1015_RS09970 (S)-S-oxide reductase: IMP dTTP phosphoribosyltransferase: phosphate acyltransferase: salicyl alcohol cyclohexen- hydroxyhexacosanoyl- phosphate acyltransferase: phosphate acyltransferase: HMPREF1015_RS08145 nucleoside- phosphate peptidoglycan biosynthesis I (meso-diaminopimelate containing) HMPREF1015_RS08780 H-hydrate epimerase: a [protein] (L-serine/L- dihydrolipoyl HMPREF1015_RS11060 HMPREF1015_RS07550 HMPREF1015_RS11060 one-carboxylate [acp] HMPREF1015_RS07550 HMPREF1015_RS07550 a protein-L-HMPREF1015_RS12330 N-acetyl-L- diphosphate kinase: adenine and dGDP dADP HMPREF1015_RS12985 preQ (S)-NADHX HMPREF1015_RS15825 1-stearoyl-2- 1,2-dimyristoyl- a 1-acyl-2- dehydrogenase: RS04770 RS03270 guanosine guanine 1 threonine) phosphate an [apo BCAA methionine orotidine-5'-phosphate adenosine salvage I xanthine and UDP-N-acetyl-α-D-glucosamine 16-hydroxypalmitoyl- stearoyl-sn sn-glycerol palmitoyl-sn methionine- HMPREF1015_RS13235 purine-nucleoside tRNA guanosine(34) L-proline degradation Amino Acid Degradation AMP diphosphate acyl-carrier protein diphosphate AMP octanoyl-CoA dehydrogenaseHMPREF1015_RS13830 decarboxylase: IMP xanthosine salvage ATP-dependent NADH- L-glutamine degradation I CoA -glycerol 3- 3-phosphate -glycerol 3- (S)-S-oxide pyrimidine ribonucleosides salvage I nucleoside- nucleoside- phosphorylase: hypoxanthine UDP-N-acetylglucosamine 6 HMPREF1015_RS10425 CMP phosphorylation transglycosylase Tgt: hydrate dehydratase: E2 protein] N dGTP diphosphate kinase: diphosphate kinase: HMPREF1015_RS12380 phosphoribosyltransferase: 1-carboxyvinyltransferase: phosphate phosphate adenosine HMPREF1015_RS14770 HMPREF1015_RS15825 -lipoyl-L-lysine gln RS06215 gln cytidine HMPREF1015_RS13235 HMPREF1015_RS13235 guanine HMPREF1015_RS00200 HMPREF1015_RS04655 pro RS01775 UMP purine-nucleoside CMP xanthosine a 7-aminomethyl-7- gln xanthine deazaguanosine 34 NADH proline dehydrogenase: carbamoyl- phosphorylase: (d)CMP kinase: purine-nucleoside UDP-N-acetylglucosamine a 2-methyl peptidoglycan peptidoglycan a (3R)-3- 1-palmitoyl- (2Z,4E)-2- pro RS08050 pro cytidine deaminase: dGTP dATP hypoxanthine phosphoribosyltransferase: in tRNA HMPREF1015_RS01110 phosphate synthase: 18-hydroxystearate oleate a ribonucleoside NaMN HMPREF1015_RS12380 HMPREF1015_RS13355 phosphorylase: 1-carboxyvinyltransferase: (S)-1-pyrroline- branched 2,3,4- tetrapeptide, tetrapeptide, hydroxyhexacosanoyl- sn-glycerol hydroxyhexa- HMPREF1015_RS02285 phosphoribosyltransferase: HMPREF1015_RS12985 GTP H O 5'-monophosphate dITP adenine CDP HMPREF1015_RS04825 tRNA preQ1(34) S- 5-carboxylate HMPREF1015_RS10405 long-chain fatty saturated fatty acid long-chain fatty 2 HMPREF1015_RS00200 HMPREF1015_RS12380 long-chain fatty glycan chain 1 glycanL,D-transpeptidase: chain 2 [acp] 3-hydroxyacyl-[acyl- 3-phosphate 1-acyl-sn-glycerol-3- bifunctional bifunctional 2,4-dienedioate RS03905 CMP xanthine UDP-N-acetyl-α-D- adenosylmethionine HMPREF1015_RS10410 acid--CoA ligase: acid--CoA ligase: ribosome small subunit- 4-oxalocrotonate pro RS12035 pro uridine nucleoside- acid--CoA ligase: HMPREF1015_RS13795 carrier-protein] phosphate acyltransferase: metallophosphatase/ metallophosphatase/ adenine xanthine GMP ribosyltransferase- [+ 8 isozymes] HMPREF1015_RS15180 HMPREF1015_RS15180 dependent GTPase A: tautomerase: XTP/dITP diphosphatase: diphosphate kinase: xanthine glucosamine-enolpyruvate HMPREF1015_RS15180 L,D-transpeptidase: dehydratase FabZ: HMPREF1015_RS13350 5'-nucleotidase: 5'-nucleotidase: phosphoribosyltransferase: uridine kinase: phosphoribosyltransferase: isomerase QueA: glu HMPREF1015_RS10505 HMPREF1015_RS04960 HMPREF1015_RS15080 HMPREF1015_RS13235 phosphoribosyltransferase: UDP-N- L-asparagine long-chain-fatty- long-chain-fatty- HMPREF1015_RS00650 HMPREF1015_RS04605 HMPREF1015_RS14080 HMPREF1015_RS14080 HMPREF1015_RS14735 HMPREF1015_RS14585 HMPREF1015_RS12985 HMPREF1015_RS14775 long-chain-fatty- peptidoglycan [+ 4 isozymes] 1-acyl-sn-glycerol-3- 4-oxalocrotonate HMPREF1015_RS12985 acetylenolpyruvoylglucosamine Glycolysis L-glutamate-5- degradation I acid--CoA ligase: acid--CoA ligase: a (2E)-hexacos- bifunctional RS08840 CTP 34 acid--CoA ligase: D-ala DAP-DAP + phosphate acyltransferase: [+ 2 isozymes] tautomerase: RS05765 UMP reductase: an epoxyqueuosine semialdehyde HMPREF1015_RS11060 HMPREF1015_RS11060 phosphate GDP H 2-enoyl-[acp] dIMP GMP HMPREF1015_RS11060a 2-methyl crosslink 1-palmitoyl- HMPREF1015_RS07550 a ribonucleoside metallophosphatase/ HMPREF1015_RS04130 AMP HMPREF1015_RS01780 in tRNA L-glutamate gamma- asn 5'-nucleotidase: (3E)-2-oxohex- XMP ala glycolysis III (from glucose) 18-hydroxystearoyl- branched 2-myristoyl glu epoxyqueuosine reductase: semialdehyde AMP diphosphate AMP diphosphate diphosphate AMP oleoyl-CoA HMPREF1015_RS01000 3-enedioate UDP-N-acetyl-α-D-muramate asparaginase: CoA 2,3,4-saturated phosphatidate β HMPREF1015_RS04320 dehydrogenase: -D- RS05335 RS12645 Fatty Acid and Lipid Biosynthesis D-glucopyranose HMPREF1015_RS13390 fatty acyl-CoA HMPREF1015_RS08870 ribosylnicotinate glutamate racemase: UDP-N-acetylmuramate- a queuosine 34 asp palmitate biosynthesis II (bacteria and plants) HMPREF1015_RS15100 -L-alanine ligase: glucokinase: palmitoleate biosynthesis I in tRNA glu fatty acid elongation -- saturated HMPREF1015_RS15650 HMPREF1015_RS14135 (15Z)- a 3-methyl- (R)-4'- 3-oxo-(9Z)- a 3,5,7,9,11,13,15- 1-palmitoyl- (from (5Z)-dodec-5-enoate) O-succinyl-L- L-alanine degradation IV branched 2,3,4- phosphopantothenoyl- methanethiol hepta-oxo- sn-glycerol (S)-NADHX DNA with lesion RS10735 D-glt D-glucopyranose tetracosenoate octadecenoyl-CoA homoserine hypoxanthine XTP RS00240 an acetoacetyl-[acp] UDP-N-acetyl-α-D-muramoyl-L-alanine long-chain fatty saturated fatty acid L-cysteine acetyl-CoA C- hexadecanoyl-[PKS-acp] 3-phosphate bifunctional ADP-dependent excinuclease ABC a (5Z)-dodec- an acetoacetyl-[acp] 6-phosphate long-chain fatty bifunctional aminotransferase 1-acyl-sn-glycerol-3- acid--CoA ligase: acyltransferase: aldo/keto reductase: NAD(P)H-hydrate subunit UvrC: 5-enoyl-[acp] lipoprotein posttranslational glucose-6-phosphate acid--CoA ligase: phosphopantothenoylcysteine class V-fold PLP- phosphate acyltransferase: xanthine dehydrogenase 3-oxoacyl-ACP beta-ketoacyl-[acyl-carrier- ala HMPREF1015_RS15180 HMPREF1015_RS01100 HMPREF1015_RS05795 dehydratase/NAD(P) HMPREF1015_RS15150 XTP/dITP diphosphatase: Carbohydrate Biosynthesis UDP-N-acetylmuramoyl-L- modification isomerase: HMPREF1015_RS15180 decarboxylase/ dependent enzyme: HMPREF1015_RS13350 subunit D: reductase FabG: protein] synthase II: alanine dehydrogenase: [+ 3 isozymes] H-hydrate epimerase: HMPREF1015_RS15080 RS03045 alanine--D-glutamate ligase: HMPREF1015_RS08850 long-chain-fatty- [+ 2 isozymes] HMPREF1015_RS12580 9-hydroxy-3,5,7,11,13,15- HMPREF1015_RS16050 excinuclease ABC: HMPREF1015_RS02605 a (7Z)-3- HMPREF1015_RS06285 a [prolipoprotein]- long-chain-fatty- phosphopantothenate-- (7Z)- 1-acyl-sn-glycerol-3- RS10310 HMPREF1015_RS10290 HMPREF1015_RS03015 acid--CoA ligase: acetyl-CoA HMPREF1015_RS15825 xanthine dehydrogenase: HMPREF1015_RS00450 gluconeogenesis I L-cysteine glucose-6-phosphate acid--CoA ligase: cysteine ligase CoaBC: succinate met hexaoxohexadecanoyl- phosphate acyltransferase: [+ 4 isozymes] oxotetradec- UDP-α-D-glucose biosynthesis I pyruvate HMPREF1015_RS11060 hexadecenoyl-CoA HMPREF1015_RS00455 XMP α isomerase: HMPREF1015_RS11060 HMPREF1015_RS10465 [PKS-acp] HMPREF1015_RS07550 NADH HMPREF1015_RS16055 a (3R)-3- 7-enoyl-[acp] a 3-oxoacyl-[acp] meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- prolipoprotein a 3-methyl- 1-palmitoyl-2- xanthine DNA without hydroxybutanoyl- 3-oxoacyl-ACP reductase: HMPREF1015_RS07390 (Z)-15- 4'-phosphopantetheine cis-vaccenoyl (S)-malate D-glucopyranose L-alanyl-D-glutamate diacylglyceryl transferase: AMP diphosphate diphosphate AMP branched lesion RS02080 HMPREF1015_RS01645 Carbohydrate Degradation tetracosenoyl-CoA phosphatidate [acp] 6-phosphate HMPREF1015_RS05660 2,3,4-saturated RS02395 D-ala F6P 3-hydroxyacyl-[acyl- [+ 4 isozymes] phosphoglucomutase: UDP-N-acetylmuramoyl-L- a [prolipoprotein]-S- fatty acyl-CoA carrier-protein] a (3R,7Z)-3- HMPREF1015_RS07275 alanyl-D-glutamate--2, 6- L-rhamnose degradation I α-D-glucopyranose diacylglyceryl-L-cysteine 6-phosphofructokinase: dehydratase FabZ: hydroxytetradec- malate dehydrogenase: D-alanine--D-alanine ligase: diaminopimelate ligase: lactose and galactose degradation I malate dehydrogenase, 1-phosphate HMPREF1015_RS15355 a very-long- (5Z,8Z,11Z,14Z,17Z) 3-oxo-(7Z)- a 3- a (7Z)-3- RS14385 HMPREF1015_RS04605 7-enoyl-[acp] 3-oxoacyl-ACP reductase: HMPREF1015_RS15325 HMPREF1015_RS10275 α-L- 18-hydroxyoleate coenzyme A O-succinyl-L- L-2,4- α-D- an organic NAD-requiring: HMPREF1015_RS09135 lipoprotein β oxodocosanoyl- oxohexacos- 3-hydroxyacyl-[acyl- HMPREF1015_RS01645 UTP--glucose-1-phosphate -D-fructose 1,6- rhamnopyranose lactose 6'- chain fatty acid -icosapentaenoate hexadecenoyl-CoA homoserine diaminobutanoate glucopyranose ATP hydroperoxide dGDP RS00705 a (2E)-but- HMPREF1015_RS15375 α Secondary Metabolite Biosynthesis signal peptidase: L-rhamnose mutarotase: long-chain fatty long-chain-fatty- long-chain-fatty- acetyl-CoA C- [acp] 7-enoyl-[acp] alkylhydroperoxidase: carrier-protein] beta-ketoacyl-[acyl-carrier- uridylyltransferase: D-alanyl-D-alanine UDP-N-acetyl- -D-muramoyl-L-alanyl- bisphosphate phosphate aminotransferase 1-phosphate 3-oxoacyl-ACP 3-oxoacyl-ACP 2-enoyl-[acp] [+ 4 isozymes] HMPREF1015_RS10380 HMPREF1015_RS07565 phospho-β-galactosidase: acid--CoA ligase: acid--CoA ligase: acid--CoA ligase: acyltransferase: diaminobutyrate--2- glucose-1-phosphate HMPREF1015_RS16330 ribonucleotide- dehydratase FabZ: protein] synthase II: HMPREF1015_RS08705 γ-D-glutamyl-meso-2,6-diaminopimelate β-L- class V-fold PLP- reductase FabG: reductase FabG: HMPREF1015_RS01440 HMPREF1015_RS15180 HMPREF1015_RS11060 HMPREF1015_RS11060 HMPREF1015_RS01100 oxoglutarate transaminase: diphosphate reductase: crotonyl-[acyl-carrier- HMPREF1015_RS04605 autoinducer AI-2 biosynthesis I fructose-1,6-bisphosphate rhamnopyranose dependent enzyme: adenylyltransferase: HMPREF1015_RS02605 HMPREF1015_RS02605 alkyl hydroperoxide RS15745 HMPREF1015_RS06285 a (3R)-3- oxaloacetate [+ 2 isozymes] preQ biosynthesis an (S-diacyl-sn- a lipoprotein D-galactopyranose HMPREF1015_RS08565 HMPREF1015_RS08125 protein] reductase: a (2E,7Z)- a 2,3,4-saturated UDP-N-acetylmuramoyl- 0 aldolase, class II: long-chain-fatty- long-chain fatty long-chain fatty [+ 2 isozymes] HMPREF1015_RS12580 HMPREF1015_RS02020 [+ 4 isozymes] [+ 4 isozymes] reductase subunit F: hydroxyacyl-[acyl- glyceryl)-L-cysteinyl- signal peptide L-rhamnose isomerase: 6-phosphate (5Z)- a (3R)-3- a (3R,7Z)-3- HMPREF1015_RS08130 RS04905 HMPREF1015_RS06065 tetradeca-2,7- fatty acyl-[acp] pyruvate UDP-α-D-glucose tripeptide--D-alanyl- acid--CoA ligase: acid--CoA ligase: acid--CoA ligase: acetyl-CoA L-aspartate- glucose-1-phosphate HMPREF1015_RS05255 carrier protein] [apolipoprotein] HMPREF1015_RS04835 HMPREF1015_RS07575 galactose-6- succinate L-homocysteine hydroxydocosanoyl- hydroxyhexacos- dienoyl-[acp] 3-hydroxyacyl-[acyl- phosphoenolpyruvate D- alanine ligase: SAM HMPREF1015_RS11060 HMPREF1015_RS15180 HMPREF1015_RS15180 tetradecenoyl-CoA semialdehyde GDP phosphate isomerase: adenylyltransferase: [acp] 7-enoyl-[acp] an alcohol a butanoyl-[acp] cis-∆ 7 -tetradecenoyl- carrier-protein] carboxykinase (ATP): HMPREF1015_RS09130 GTP (5Z,8Z,11Z,14Z,17Z) RS12960 keto-L-rhamnulose HMPREF1015_RS01450 18-hydroxyoleoyl- a very-long-chain HMPREF1015_RS02015 [acp]:NAD+ dehydratase FabZ: HMPREF1015_RS06925 triose-phosphate AMP diphosphate AMP diphosphate -icosapentaenoyl-CoA ADP-α-D-glucose GTP cyclohydrolase I FolE: HMPREF1015_RS01455 CoA fatty acyl-CoA beta-ketoacyl-[acyl-carrier- oxidoreductase: HMPREF1015_RS04605 UDP-N-acetyl-α-D-muramoyl-L- an N-acyl-(S-diacyl- isomerase: RS11120 SAH 7,8- HMPREF1015_RS13260 a peptide protein] synthase II: HMPREF1015_RS06065 phosphoenol alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate sn-glyceryl)-L- HMPREF1015_RS05495D-glyceraldehyde D-tagatofuranose α dihydroneopterin pyruvate UDP- -D-galactose biosynthesis diaminopimeloyl-D-alanyl-D-alanine cysteinyl-[lipoprotein] DHAP 3-phosphate 6-phosphate HMPREF1015_RS06285 a (7Z)-tetradec- 5'-methylthioadenosine/ 3'-triphosphate RS15505 L-rhamnulofuranose a non- phosphoenol an [HPr]- (5E)-3-oxo- 1-oleoyl-sn a 3- a (5Z)-3- an [RNA]-3'- 3-oxoacyl-[acyl-carrier- 7-enoyl-[acp] phosphopyruvate glyceraldehyde-3- tagatose-6- α S-methyl-L- α S-adenosylhomocysteine 6-carboxytetrahydropterin 7-hydroxylaurate -linolenate L-homocysteine UDP-α-D- glucuronated dodec-5- -glycerol 3- oxodocosanoyl- oxotetracos- ribonucleoside- protein] reductase: hydratase: UDP- -D-glucose phosphate dehydrogenase: phosphate kinase: pyruvate L-histidine ITP beta-ketoacyl-[acyl-carrier- nucleosidase: synthase QueD: rhamnulokinase: long-chain fatty long-chain-fatty- methionine glucuronate glucosyluronate phosphoenolpyruvate- enoyl-CoA phosphate [acp] 5-enoyl-[acp] 2',3'- RS09895 HMPREF1015_RS10560 HMPREF1015_RS05485 UDP-glucose 4- HMPREF1015_RS15295 HMPREF1015_RS01465 bifunctional homocysteine acetyl-CoA C- 1-acyl-sn-glycerol-3- 3-oxoacyl-ACP 3-oxoacyl-ACP protein] synthase II: a trans-2- HMPREF1015_RS14570 HMPREF1015_RS08770 5-oxo-L-proline metabolism HMPREF1015_RS07580 acid--CoA ligase: acid--CoA ligase: acceptorUDP- -protein cyclophosphate a 2,3,4-saturated epimerase GalE: undecaprenyldiphospho- D-tagatofuranose S-methyltransferase/ acyltransferase: phosphate acyltransferase: reductase FabG: reductase FabG: RNA 2',3'-cyclic RS10030 a 3-oxohexanoyl- HMPREF1015_RS06285 enoyl-[acyl- 2-phospho- 6-carboxy-5,6,7,8- L-rhamnulose HMPREF1015_RS15180 HMPREF1015_RS11060 glucuronosyltransferase: phosphotransferase: XTP/dITP diphosphatase: fatty acyl-[acp] HMPREF1015_RS07270 N-acetylmuramoyl-L-alanyl- S-ribosyl-L-homocysteine 13-DPG 1,6-bisphosphate methylenetetrahydrofolate HMPREF1015_RS04895 HMPREF1015_RS13350 HMPREF1015_RS02605 HMPREF1015_RS02605 phosphodiesterase: [acp] carrier protein] D-glycerate γ tetrahydropterin an N-terminal 1-phosphate a glucuronatedHMPREF1015_RS08460 HMPREF1015_RS09790 HMPREF1015_RS15080 3-oxoacyl-[acyl-carrier- -D-glutamyl-meso-2,6- tagatose-1,6- long-chain-fatty- long-chain fatty reductase: an [HPr protein]- a (3R)-3-[+ 4 isozymes] a (3R,5Z)-3-[+ 4 isozymes] HMPREF1015_RS15715 2,3-bisphosphoglycerate- UDP-N-acetyl-D- UDP-glucose 4-epimerase: L-glutaminyl- an N-terminal L- UDP glucosyluronate [+ 2 isozymes] 1-acyl-sn-glycerol-3- an [RNA]-3'- 3-oxoacyl-ACP protein] reductase: 2,3,4-saturated fatty Amine and Polyamine Biosynthesis diaminopimeloyl-D-alanyl-D-alanine 7-carboxy-7-deazaguanine rhamnulose-1- ribose phosphorylation acid--CoA ligase: acid--CoA ligase: HMPREF1015_RS06950 π pyruvate (3E)-dec-3- RS00195 glucosamine biosynthesis I HMPREF1015_RS04275 S-ribosylhomocysteine [protein] glutamyl-[protein] phosphoglycerate kinase: bisphosphate N -phospho- acetyl-CoA phosphate acyltransferase: hydroxydocosanoyl- hydroxytetracos- ribunucleoside- reductase FabG: HMPREF1015_RS10560 acyl-[acp]:NAD+ independent α synthase QueE: phosphate aldolase: HMPREF1015_RS11060 HMPREF1015_RS15180 acceptor enoyl-CoA IMP UDP- -D-galactose undecaprenyldiphospho- lyase: HMPREF1015_RS05500 aldolase: kbaY met L-histidine HMPREF1015_RS07550 [acp] 5-enoyl-[acp] RS07300 a (9Z)-3- oxidoreductase: phosphoglycerate mutase: D-glucopyranose HMPREF1015_RS08775 HMPREF1015_RS07570 2'-phosphate HMPREF1015_RS02605 spermidine biosynthesis III muramoylpentapeptide beta-N- HMPREF1015_RS02575 D-glyceraldehyde β-D-ribopyranose 7-hydroxylauroyl- dioleoyl oxohexadec- HMPREF1015_RS06065 HMPREF1015_RS05490 6-phosphate putrescine biosynthesis I 3-phospho- DHAP AMP diphosphate AMP diphosphate α-linolenoyl-CoA [+ 4 isozymes] glucose-6-phosphate acetylglucosaminyltransferase: 7-carboxy-7- (S)-lactaldehyde DHAP 3-phosphate D-ribose pyranase: CoA phosphatidate 9-enoyl-[acp] 3-phospho- AI-2 D-glycerate a (3R)-3- isomerase: HMPREF1015_RS10300 deazaguanine a [protein] with HMPREF1015_RS04990 RS11425 3-oxoacyl-ACP D-glycerate hydroxyhexanoyl- HMPREF1015_RS08850 arg SAM 7-cyano-7-deazaguanine an N-terminal 5- D-ribose pyranase: RS00835 reductase FabG: PRPP biosynthesis arg lipid II (meso diaminopimelate containing) γ-L-glutamyl [acp] phosphoglycerate kinase: synthase QueC: oxo-L-proline glutathione HMPREF1015_RS16865 HMPREF1015_RS02605 glucose-6-phosphate arginine decarboxylase, 5-phosphate an N-formyl-L- 3-oxo-(9Z)- adenine 1518 / (S)-4-amino-5- an (11Z)-3- a (9Z)-3- 3-hydroxyacyl-[acyl- gondoate biosynthesis (anaerobic) HMPREF1015_RS05500 arginine decarboxylase, S-adenosylmethionine HMPREF1015_RS08765 β-D-ribofuranose 1-myristoyl-sn- pristanate a 3-oxoicosanoyl- isomerase: a palmitoleoyl-[acp] 1519 a RNA-DNA hybrid oxooctadec- oxooctacos- carrier-protein] [+ 4 isozymes] D-ribose 5- biosynthetic: 2-phospho- methionylaminoacyl- hexadecenoyl-CoA adenine in 16S rRNA oxopentanoate dADP HMPREF1015_RS07390 biosynthetic: decarboxylase proenzyme: (2R,4S)-2-methyl-2,4- pyroglutamyl-peptidase I: trehalose degradation I (low osmolarity) glycerol 3-phosphate long-chain fatty acetyl-CoA C- 16S rRNA (adenine(1518)- ribonuclease HII: glutamate-1-semialdehyde [acp] 11-enoyl-[acp] 9-enoyl-[acp] dehydratase FabZ: a (3R,9Z)-3- phosphate HMPREF1015_RS09990 preQ D-glycerate 1-acyl-sn-glycerol-3- tRNA peptide deformylase: 3-oxoacyl-ACP 3-oxoacyl-ACP 3-oxoacyl-ACP RS14380 13-DPG HMPREF1015_RS09990 HMPREF1015_RS15290 dihydroxydihydrofuran-3-one 0 HMPREF1015_RS03635 ribonucleotide- hydroxyhexadec- a malonyl-[acp] an oleoyl-[acp] F6P ribose-phosphate agmatine phosphopyruvate phosphate acyltransferase: acid--CoA ligase: acyltransferase: N(6)/adenine(1519)-N(6))- HMPREF1015_RS10630 2,1-aminomutase: reductase FabG: reductase FabG: reductase FabG: RS06370 HMPREF1015_RS04605 α,α-trehalose HMPREF1015_RS10475 diphosphate reductase: 9-enoyl-[acp] beta-ketoacyl-[acyl-carrier- pyrophosphokinase: agmatine dAdoMet hydratase: HMPREF1015_RS13350 HMPREF1015_RS15180 HMPREF1015_RS01100 dimethyltransferase RsmA: ribonuclease HIII: HMPREF1015_RS06800 HMPREF1015_RS02605 HMPREF1015_RS02605 HMPREF1015_RS02605 a (2E)-hex- glyceraldehyde-3- glutamine--fructose-6- HMPREF1015_RS00300 6-phosphate α peptide deformylase: HMPREF1015_RS08125 3-hydroxyacyl-[acyl- agmatinase: HMPREF1015_RS05485 -D-ribofuranose [+ 2 isozymes] 6 HMPREF1015_RS003451518 protein] synthase II: 5-oxo-L-proline 1-acyl-sn-glycerol-3- long-chain-fatty- HMPREF1015_RS09950 N -dimethyladenine HMPREF1015_RS15205 glutamate-1-semialdehyde- [+ 4 isozymes] [+ 4 isozymes] [+ 4 isozymes] 2-enoyl-[acp] carrier-protein] triose-phosphate phosphate dehydrogenase: phosphate transaminase PRPP HMPREF1015_RS04930 (7Z)- a nucleoside 5'- a (3R)-3- a (3R,11Z)-3- a cis-delta9-3- HMPREF1015_RS08130 an (11Z)-3- HMPREF1015_RS06285 phosphoenol phosphate acyltransferase: acid--CoA ligase: a L-methionylaminoacyl- acetyl-CoA /N 6 -dimethyladenine 1519 2,1-aminomutase: isomerase: HMPREF1015_RS15295 (isomerizing): polyamine (2R,4S)-2-methyl-2,3,3,4- alpha,alpha- ribokinase: formate tetradecenoyl-CoA DNA hydroxyicosanoyl- hydroxyoctadec- hydroxyC28:1- RS03225 hexanoyl-[acyl-carrier- dehydratase FabZ: oxo-icos-11- pyruvate HMPREF1015_RS11060 tRNA monophosphate HMPREF1015_RS15000 ADP RS11195 HMPREF1015_RS05495 aminopropyltransferase: putrescine tetrahydroxytetrahydrofuran phosphotrehalase: HMPREF1015_RS05005 1-myristoyl-2-HMPREF1015_RS07550 in 16S rRNA [acp] 11-enoyl-[acp] [acp] protein] reductase: HMPREF1015_RS04605 enoyl-[acp] D-glyceraldehyde HMPREF1015_RS12755 DHAP HMPREF1015_RS09660 pyruvate kinase: HMPREF1015_RS09505 acyl-carrier protein palmitoleoyl-sn- 5-aminolevulinate HMPREF1015_RS06065 a (2E,9Z)- 3-oxoacyl-ACP reductase: 3-phosphate D-glucosamine α-D-ribose AMP diphosphate pristanoyl-CoA hexadeca-2,9- HMPREF1015_RS15350 glycerol 3-phosphate HMPREF1015_RS01645 6-phosphate glu 5-phosphate 1 a hexanoyl-[acp] dienoyl-[acp] [+ 4 isozymes] phosphoglucosamine S-methyl-5'- N -(3-aminopropyl) glucokinase: RS02220 RS03930 palmitoleoyl-[acp]:NAD+ pyruvate C1 Compound Utilization a (3R,11Z)-3- fructose-1,6-bisphosphate mutase: thioadenosine agmatine HMPREF1015_RS14135 D-glucopyranose and Assimilation 6 3-oxoacyl-[acyl-carrier- oxidoreductase: hydroxy-icos- HMPREF1015_RS12760 D-glucopyranose an N -L- 4-hydroxybenzoyl- a pseudouridine 1915 a guanine 34 a (6Z)-3- aldolase, class II: 6-phosphate 1-cis-vaccenoyl-sn- phytenate 37 acetyl-CoA citrate a 3-oxopimeloyl- HMPREF1015_RS06065 11-enoyl-[acp] a palmitoleoyl-[acp] threonylcarbamoyladenine queuine oxooctadec- a malonyl-[acp] protein] reductase: HMPREF1015_RS04835 D-glucosamine xylose degradation I formate assimilation into 5,10- glycerol-3-phosphate CoA in 23S rRNA in tRNA [acp] methyl ester dIDP 3-hydroxyacyl-[acyl- long-chain-fatty- in tRNA acetyl-CoA C- 23S rRNA tRNA guanosine(34) aconitate hydratase AcnA: 6-enoyl-[acp] HMPREF1015_RS10560 1-phosphate N 6 -L- methylenetetrahydrofolate 1-acyl-sn-glycerol-3- tRNA 3-oxoacyl-ACP 3-oxoacyl-ACP malonyl-[acyl- RS16320 RS06550 a palmitoleoyl-[acp] carrier-protein] acid--CoA ligase: acyltransferase: (pseudouridine(1915)-N(3) transglycosylase Tgt: HMPREF1015_RS02940 beta-ketoacyl-[acyl-carrier- bifunctional UDP-N- spermidine threonylcarbamoyladenosine 37 D-xylopyranose phosphate acyltransferase: threonylcarbamoyladenosine reductase FabG: reductase FabG: carrier protein] O- nucleoside- dehydratase FabZ: HMPREF1015_RS13350 HMPREF1015_RS11060 dehydratase: HMPREF1015_RS04895 )-methyltransferase RlmH: HMPREF1015_RS14770 bifunctional 2- HMPREF1015_RS02605 HMPREF1015_RS02605 diphosphate kinase: protein] synthase II: β acetylglucosamine -modified tRNA biosynthesis fructose degradation xylose isomerase: formate methyltransferase BioC: HMPREF1015_RS04605 -D-fructose 1,6- [+ 2 isozymes] HMPREF1015_RS05250 34 HMPREF1015_RS06285 formate-- 1-acyl-sn-glycerol-3- long-chain fatty a cyclic N 6 -L-HMPREF1015_RS14700 an N 3 - a queuosine methylcitrate dehydratase/ a (3R)-3-[+ 4 isozymes] a (3R,6Z)-3-[+ 4 isozymes] HMPREF1015_RS09835 HMPREF1015_RS13235 bisphosphate diphosphorylase/ HMPREF1015_RS15990 4-hydroxybenzoyl- guanine a malonyl-[acp] a (2E,11Z)-icosa- thr β-D-fructofuranose tetrahydrofolate ligase: phosphate acyltransferase: acid--CoA ligase: threonylcarbamoyladenosine methylpseudouridine 1915 in tRNA aconitate hydratase: RS06790 a 3-oxooctanoyl- glucosamine-1-phosphate D-xylulose acetyl-CoA hydroxypimeloyl- hydroxyoctadec- 2,11-dienoyl-[acp] fructose-1,6- threonylcarbamoyl- 1-phosphate HMPREF1015_RS12905 HMPREF1015_RS07550 HMPREF1015_RS15180 37 in tRNA in 23S rRNA HMPREF1015_RS07435 methyl ester dITP RS13400 [acp] palmitoleate N-acetyltransferase GlmU: 1-phosphofructokinase: an N 10 - 1-cis-vaccenoyl- [acp] methyl ester 6-enoyl-[acp] bisphosphatase: AMP synthase: D-threo-isocitrate (2E,11Z)-icosa-2,11- HMPREF1015_RS00305 HMPREF1015_RS01465 xylulokinase: acyl-carrier protein 2-palmitoleoyl-sn- 3-oxoacyl-ACP HMPREF1015_RS04820 HMPREF1015_RS04765 formyltetrahydrofolate diphosphate AMP phytenoyl-CoA dienoyl-[acp] reductase: N-acetyl-α-D- (L-threonylcarbamoyl) HMPREF1015_RS12090 glycerol-3-phosphate reductase FabG: phosphatidylglycerol 1-phosphofructokinase: bifunctional RS09580 HMPREF1015_RS06065 F6P glucosamine adenylate HMPREF1015_RS07015 D-xylulose HMPREF1015_RS02605 biosynthesis I (plastidic) β-D-fructose 1,6- methylenetetrahydrofolate RS12030 1-phosphate Respiration 5-phosphate dehydrogenase/ [+ 4 isozymes] a gondoyl-[acp] glucose-6-phosphate bisphosphate a DNA containing a (3R)-3- DHAP bifunctional UDP-N- methenyltetrahydrofolate a [protein]- 6-trans-3-oxo- 5'-deoxy-5'- a 3-oxoglutaryl- a cis-delta15-3- (S)-1-pyrroline- isomerase: 1-palmitoyl-sn- linoleate S methyl a purine preuroporphyrinogen acetylglucosamine 6 a palmitoleoyl-[acp] p tridecenoyl-CoA 5-carboxylate hydroxyoctanoyl- NAD(P)H-dependent HMPREF1015_RS08850 an N -L- 2-oxoglutarate decarboxylation to succinyl-CoA cyclohydrolase FolD: glycerol 3-phosphate L-cysteine fluoroadenosine [acp] methyl ester oxo-C34:1-[acp] IDP diphosphorylase/ 37 long-chain fatty phosphotriester acetyl-CoA C- ribonucleoside purine-nucleoside uroporphyrinogen- L-glutamate gamma- RS14780 [acp] glycerol-3-phosphate threonylcarbamoyladenine HMPREF1015_RS13900 1-acyl-sn-glycerol-3- methylated-DNA-- purine-nucleoside 3-oxoacyl-ACP 3-oxoacyl-ACP glucose-6-phosphate glucosamine-1-phosphate a [2-oxoglutarate acid--CoA ligase: acyltransferase: phosphorylase: III synthase: semialdehyde RS07235 3-hydroxyacyl-[acyl- dehydrogenase: in tRNA a 5,10- phosphate acyltransferase: [protein]-cysteine S- phosphorylase: reductase FabG: reductase FabG: nucleoside- isomerase: N-acetyltransferase GlmU: dehydrogenase HMPREF1015_RS15180 HMPREF1015_RS04895 HMPREF1015_RS12380 HMPREF1015_RS15010 dehydrogenase: carrier-protein] HMPREF1015_RS13305 methenyltetrahydrofolate HMPREF1015_RS13350 methyltransferase: HMPREF1015_RS12380 HMPREF1015_RS02605 HMPREF1015_RS02605 diphosphate kinase: sn-glycerol HMPREF1015_RS07390 6 5-fluoro-5- HMPREF1015_RS08870 dehydratase FabZ: long-chain fatty HMPREF1015_RS00305 E2 protein] N 2-oxoglutarate 1-acyl-sn-glycerol-3- long-chain-fatty- aHMPREF1015_RS01890 DNA without [+ 2 isozymes] α-D-ribose- uroporphyrinogen- a (3R)-3-[+ 4 isozymes] a cis-delta15-3-[+ 4 isozymes] HMPREF1015_RS13235 3-phosphate D-glucopyranose bifunctional a [protein]-S- 4-trans- a purine base deoxy-D-ribose adenine RS04100 HMPREF1015_RS04605 acid activation UDP-N-acetyl- -lipoyl-L-lysine dehydrogenase phosphate acyltransferase: acid--CoA ligase: S methyl acetyl-CoA 1-phosphate III synthase: hydroxyglutaryl- hydroxyC34:1- glu methylenetetrahydrofolate methyl-L-cysteine p undecenoyl-CoA 1-phosphate glycerol-3-phosphate 1- 6-phosphate α-D-glucosamine 2-oxoglutarate E1 component: HMPREF1015_RS07550 HMPREF1015_RS11060 phosphotriester HMPREF1015_RS02370 ITP a (2E)-oct- a long-chain dehydrogenase/ 1-palmitoyl-2- [acp] methyl ester [acp] RS01570 O-acyltransferase PlsY: dehydrogenase HMPREF1015_RS15845 Amine and Polyamine Degradation uroporphyrinogen-III 2-enoyl-[acp] fatty acid methenyltetrahydrofolate acyl-carrier protein palmitoleoyl-sn- HMPREF1015_RS02910 long-chain-fatty- E1 component: AMP diphosphate linoleoyl-CoA cyclohydrolase FolD: glycerol 3-phosphate RS06970 octanoyl-[acyl-carrier- a 1-acyl-sn acid--CoA ligase: HMPREF1015_RS15845 N-acetylglucosamine HMPREF1015_RS13900 protein] reductase: -glycerol 3- HMPREF1015_RS11060 [+ 2 isozymes] a [2-oxoglutarate a [2-oxoglutarate degradation I allantoin degradation HMPREF1015_RS06065 phosphate to ureidoglycolate II a 5,10- RS10715 long-chain fatty dehydrogenase dehydrogenase N-acetyl-D- an [amino group carrier protein]- an oxidized 1-acyl-sn-glycerol-3- glyoxylate cycle (ammonia producing) methylenetetrahydrofolate 6-cis, 3-oxo- a 2'- 5'-chloro-5'- a (3R)-3- acid--CoA ligase: E2 protein] N 6 E2 protein] N 6 -S- glucosamine a 2,3,4-saturated a 2,3,4-saturated 2- seleno-L- γ a cis-delta21-3- acetyl-CoA an octanoyl-[acp] phosphate acyltransferase: C-terminal- -(L-glutamate 5- tridecenoyl-CoA deoxyribonucleoside [DNA] deoxyadenosine L-homocysteine hydroxydocosanoyl- nitroaromatic RS11410 HMPREF1015_RS15180 -dihydrolipoyl- succinyldihydrolipoyl- 6-phosphate (S)-(+)-allantoin fatty acyl-[acp] lysophosphatidate homocysteine oxo-C40:1-[acp] a long-chain N-acetylglucosamine-6- 1-acyl-sn-glycerol-3- 5-methyltetrahydropteroyltriglutamate- semialdehyde-2-yl)-L-glutamate acetyl-CoA C- 5'-triphosphate DNA polymerase III purine-nucleoside [acp] 3-oxoacyl-ACP compound acetyl-CoA carboxylase HMPREF1015_RS07550 succinate acetyl-CoA N-acetyl-gamma-glutamyl- bifunctional homocysteine 3-hydroxyacyl-[acyl- fatty acyl-CoA L-lysine L-lysine phosphate deacetylase: allantoinase: phosphate acyltransferase: acyltransferase: phosphorylase: biotin carboxyl: 3-oxoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- - homocysteine S-methyltransferase: subunit gamma/tau: S-methyltransferase/ carrier-protein] reductase FabG: NAD(P)H nitroreductase: RS12560 HMPREF1015_RS05680 HMPREF1015_RS16005 phosphate reductase: HMPREF1015_RS04895 HMPREF1015_RS12380 HMPREF1015_RS01185 protein] reductase: phosphate acyltransferase: D-glucosamine HMPREF1015_RS13350 HMPREF1015_RS12130 HMPREF1015_RS00030 methylenetetrahydrofolate dehydratase FabZ: HMPREF1015_RS02605 HMPREF1015_RS08640 HMPREF1015_RS08150 5-chloro-5- HMPREF1015_RS01190 HMPREF1015_RS10560 6-phosphate allantoate 5-methyltetrahydropteroyltriglutamate- an [amino group carrier protein]- [+ 2 isozymes] [+ 7 isozymes] reductase: HMPREF1015_RS04605 [+ 4 isozymes] a reduced RS04750 HMPREF1015_RS13350 glyoxylate 1-acyl-sn-glycerol-3- 4-cis- adenine deoxyribose a cis-delta21-3- a 1,2-diacyl- dihydrolipoyllysine-residue C-terminal-γ-(5-phospho- acetyl-CoA a (2E)-docos- nitroaromatic [+ 3 isozymes] beta-ketoacyl-[acyl-carrier- phosphate acyltransferase: - homocysteine S-methyltransferase: undecenoyl-CoA [DNA] 1-phosphate HMPREF1015_RS06950 hydroxyC40:1- sn-glycerol succinyltransferase: allantoate amidohydrolase: L-glutamyl)-L-glutamate 2-enoyl-[acp] compound malonyl-CoA protein] synthase II: acyl-CoA hydrolysis malate synthase A: a HMPREF1015_RS075502,3,4-saturated HMPREF1015_RS12155 met [acp] 3-phosphate isocitrate lyase: HMPREF1015_RS15840 HMPREF1015_RS16020 RS06795 HMPREF1015_RS06285 HMPREF1015_RS08040 α-D-glucosamine acyl-carrier protein 1,2-diacyl-sn- SeMet phosphatidate HMPREF1015_RS08045 2-oxoglutarate RS11100 a 3-oxodecanoyl- a 2,3,4-saturated 6-phosphate (S)-ureidoglycine glycerol 3-phosphate cytidylyltransferase: dehydrogenase [acp] fatty acyl CoA glucosamine-6- HMPREF1015_RS10880 acyl-CoA thioesterase: E1 component: Amino Acid Biosynthesis phosphate deaminase: 4-aminobutanoate degradation I 3-oxoacyl-ACP a CDP- HMPREF1015_RS07035 HMPREF1015_RS15845 1-palmitoyl- 2-phospho-4-(cytidine 5'- 3-oxo-(7Z)- a (3R)-3- D-gluconate RS07055 HMPREF1015_RS00445 a purine 2'- hydantoin (R)-NADPHX a cis-delta13-3- DHAP reductase FabG: diacylglycerol [+ 2 isozymes] a palmitoyl-[acp] a malonyl-[acp] a palmitoyl-[acp] sn-glycerol diphospho)-2-C-methyl-D-erythritol tetradecenoyl-CoA hydroxyicosanoyl- 6-phosphate a 2,3,4-saturated acetyl-CoA C- oxo-C32:1-[acp] RS09455 HMPREF1015_RS02605 L-histidine biosynthesis D-threo-isocitrate (S)-malate 4-aminobutanoate 3-oxoacyl-[acyl-carrier- 3-phosphate1-acyl-sn-glycerol-3- 2-C-methyl-D-erythritol deoxyribonucleoside hydantoinase/oxoprolinase bifunctional ADP-dependent [acp] 3-hydroxyacyl-[acyl- 3-oxoacyl-ACP NAD(P)H-dependent 6-phosphogluconate CDP-diacylglycerol-- fatty acid L-lysine biosynthesis II superpathway of branched chain amino acid biosynthesis L-homoserine and L-methionine biosynthesis L-arginine biosynthesis I (via L-ornithine) L-arginine biosynthesis II (acetyl cycle) L-isoleucine biosynthesis IV L-threonine biosynthesis F6P (S)-ureidoglycolate purine-nucleoside [+ 4 isozymes] 4-aminobutyrate--2- protein] reductase: 2,4-cyclodiphosphate acyltransferase: NAD(P)H-hydrate glycerol-3-phosphate dehydrogenase glycerol-3-phosphate 3- phosphate acyltransferase: phosphorylase: family protein: carrier-protein] reductase FabG: a (3R)-3- bifunctional 2- oxoglutarate transaminase: HMPREF1015_RS10560 HMPREF1015_RS13350 synthase: HMPREF1015_RS01100 HMPREF1015_RS04400 dehydratase/NAD(P) HMPREF1015_RS02605 dehydrogenase: (decarboxylating): phosphatidyltransferase: PRPP α HMPREF1015_RS12380 dehydratase FabZ: RS15410 hydroxydecanoyl- pyruvate thr asp glu N-acetylglutamyl- propanoate methylcitrate dehydratase/ HMPREF1015_RS02690 HMPREF1015_RS11730 [+ 2 isozymes] 2-deoxy- - H-hydrate epimerase: HMPREF1015_RS13305 HMPREF1015_RS07395 HMPREF1015_RS00730 asp L-homoserine beta-ketoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- HMPREF1015_RS04605 a cis-delta13-3-[+ 4 isozymes] RS10015 [acp] ATP phosphate long-chain fatty aconitate hydratase: malate dehydrogenase: succinate semialdehyde 2-C-methyl-D-erythritol- (5Z)- D-ribose 1- a purine base N-carbamoylglycine HMPREF1015_RS15825 sn-glycerol [+ 2 isozymes] acetolactate synthase: N-acetyl-gamma-glutamyl- protein] synthase II: phosphate acyltransferase: CMP acetyl-CoA a (2E)-icos- hydroxyC32:1- 1-(3-sn- aspartate kinase: acid--CoA ligase: homoserine kinase: HMPREF1015_RS07435 2,4-cyclodiphosphate dodecenoyl-CoA phosphate 3-phosphate D-ribulose 3-hydroxyacyl-[acyl- phosphoribosyltransferase: threonine dehydratase: aspartate kinase: bifunctional glutamate phosphate reductase: HMPREF1015_RS15325 allantoin degradation (S)-NADPHX 2-enoyl-[acp] phosphatidyl) HMPREF1015_RS15145 HMPREF1015_RS04075 HMPREF1015_RS15180 HMPREF1015_RS15905 NAD-dependent HMPREF1015_RS06285 HMPREF1015_RS07550 [acp] 5-phosphate carrier-protein] HMPREF1015_RS05630 HMPREF1015_RS09720 HMPREF1015_RS15145 N-acetyltransferase/ HMPREF1015_RS08150 aconitate hydratase AcnA: to ureidoglycolate a 3-oxooctadecanoyl- dipalmitoyl -sn-glycerol [+ 2 isozymes] HMPREF1015_RS04080 acetylglutamate kinase: O-phospho- succinate-semialdehyde acyl-carrier protein acyl-carrier protein dehydratase FabZ: ATP L-aspartyl- [+ 2 isozymes] amino-acid bifunctional glutamate long-chain-fatty- HMPREF1015_RS02940 Electron Transfer I (urea producing) [acp] phosphatidate RS02390 3-phosphate (2Z)-2-aminobut- HMPREF1015_RS08140 L-homoserine dehydrogenase: gabD RS09445 HMPREF1015_RS04605 4-phosphate (S)-2-acetolactate acetyltransferase ArgJ: N-acetyltransferase/ acid--CoA ligase: phosphatidylglycerophosphatase phosphoribosyltransferase 2-enoate L-aspartyl- cis-aconitate oxaloacetate (S)-(+)-allantoin HMPREF1015_RS08145 amino-acid HMPREF1015_RS11060 threonine synthase: urea degradation I NAD-dependent a (2E)-dec- regulatory subunit: ATP biosynthesis allantoinase: A: HMPREF1015_RS00950 aspartate-semialdehyde ketol-acid 4-phosphate acetyltransferase ArgJ: propanoyl-CoA HMPREF1015_RS15910 succinate-semialdehyde 1-palmitoyl- DNA with adenine:7,8- a (3R,5Z)-3- (3R,5S)-3- 2-enoyl-[acp] HMPREF1015_RS05635 N-acetyl-L- 3-oxo-(11Z)- a cis-delta11-3- sn-glycerol an L-1- dehydrogenase: reductoisomerase: HMPREF1015_RS16005 dehydrogenase: gabD a cis- a purine sn-glycerol 3-phosphate (S)-NADPHX aspartate-semialdehyde HMPREF1015_RS08145 N-acetyl-L-glutamate an acetyl-[acp] a malonyl-[acp] sn-glycerol octadecenoyl-CoA dihydro-8- hydroxydodec- hydroxy-1- decanoyl-[acyl-carrier- phosphatidyl- 1-(5-phospho- HMPREF1015_RS00800 HMPREF1015_RS04070 glutamate glu 2-oxoacid ferredoxin allantoate urea vaccenoyl-[acp] arsenate oxo-C30:1-[acp] 3-phosphate RS06965 RS11350 dehydrogenase: N-acetyl-L-glutamate thr beta-ketoacyl-[acyl-carrier- 3-phosphate ribonucleoside acetyl-CoA C- oxoguanine mismatchA/G-specific adenine bifunctional ADP-dependent 5-enoyl-[acp] 3-oxoacyl-ACP pyrroline-5- β-D-ribosyl)-ATP (2R)-2,3- 5-semialdehyde oxidoreductase bifunctional 2- ADP succinate 1-acyl-sn-glycerol-3- purine-nucleoside glycerol-3-phosphate 1- 3-hydroxyacyl-[acyl- glycerol-3-phosphate 1- protein] reductase: sn-glycerol L-aspartate- 2-iminobutanoate citrate synthase: acyltransferase: NAD(P)H-hydrate carboxylate HMPREF1015_RS00800 acetylglutamate kinase: protein] synthase II: phosphate acyltransferase: glycosylase: O-acyltransferase PlsY: carrier-protein] reductase FabG: O-acyltransferase PlsY: HMPREF1015_RS06065 phosphoribosyl-ATP dihydroxy-3- subunit beta: methylcitrate dehydratase/HMPREF1015_RS07430 flagellum-specific phosphorylase: HMPREF1015_RS01100 pyrroline-5- semialdehyde HMPREF1015_RS08140 HMPREF1015_RS06285 HMPREF1015_RS13350 HMPREF1015_RS06760 dehydratase/NAD(P) dehydratase FabZ: HMPREF1015_RS02605 HMPREF1015_RS02910 pyrophosphatase: methylbutanoate L-aspartate- HMPREF1015_RS00680 aconitate hydratase: ATP synthase FliI: urea-1-carboxylate HMPREF1015_RS12380 HMPREF1015_RS02910 carboxylate reductase: citrate synthase: acetyl-CoA 3-oxoacyl-[acyl-carrier- [+ 2 isozymes] an apurinic site H-hydrate epimerase: HMPREF1015_RS04605 [+ 4 isozymes] 1-oleoyl-sn a decanoyl-[acp] HMPREF1015_RS05600 4-hydroxy- 2,3-dihydroxy- semialdehyde N-acetylglutamyl- acetylornithine HMPREF1015_RS07435 HMPREF1015_RS10725 1-acyl-sn-glycerol-3- ribose-1-arsenate a purine base adenine 1-(18-hydroxyoleoyl)- a cis-delta11-3- HMPREF1015_RS13690 RS10265 RS09845 2-oxobutanoate HMPREF1015_RS15335 palmitoleoyl-CoA acetyl-CoA within DNA HMPREF1015_RS15825 a (2E,5Z)-dodeca- -glycerol 3- β tetrahydrodipicolinate isovalerate dehydratase: phosphate transaminase: aconitate hydratase AcnA: (S)-ureidoglycolate allophanate protein] reductase: phosphate acyltransferase: sn-glycrol 3-phosphate hydroxyC30:1- 1-(5-phospho- - homoserine gln [+ 2 isozymes] 4-aminobutanoate degradation III NADPH 3,5-dienoyl-[acp] phosphate Hyp 3-oxoacyl-[acyl-carrier- stearate biosynthesis synthase: HMPREF1015_RS04085 2-oxobutanoate HMPREF1015_RS08135 citrate ATP hydrolase subunit 1: HMPREF1015_RS10560 HMPREF1015_RS075501-palmitoyl-2- [acp] D-ribosyl)-AMP dehydrogenase: N-acetyl-gamma-glutamyl- acetolactate synthase: HMPREF1015_RS02940 protein] reductase: II (bacteria and plants) HMPREF1015_RS00790 HMPREF1015_RS07130 an acetoacetyl-[acp] acyl-carrier protein acyl-carrier protein cis-vaccenoyl bifunctional phosphoribosyl- (2S,4S)-4- 3-methyl-2- acetolactate synthase: HMPREF1015_RS15915 phosphate reductase: carbamoyl- HMPREF1015_RS04075 HMPREF1015_RS10560 oxobutanoate HMPREF1015_RS04080 4-aminobutanoate phosphatidate RS11455 AMP cyclohydrolase/ hydroxy-2,3,4,5- HMPREF1015_RS04075 homoserine HMPREF1015_RS08150 phosphate synthase: ammonium 4-aminobutyrate--2- RS03615 beta-ketoacyl-[acyl-carrier- a palmitoyl-[acp] N-acetyl-L- N-acetyl-L-ornithine phosphoribosyl-ATP tetrahydrodipicolinate HMPREF1015_RS04080 dehydrogenase: HMPREF1015_RS10405bifunctional glutamate (S)-2-aceto-2- urea degradation II oxoglutarate transaminase: protein] synthase II: 3-oxo-stearoyl- 2-isopropylmalate branched-chain-amino- glutamate 5- diphosphatase HisIE: 4-hydroxy- (S)-2-aceto-2- HMPREF1015_RS00500 HMPREF1015_RS10410N-acetyltransferase/ hydroxybutanoate 1-stearoyl- 1-cis-vaccenoyl- an [amino group carrier protein]-C- a [protein] N-terminal- an insertion sequence a (3R)-3- HMPREF1015_RS06285 [acp] synthase: acid transaminase: HMPREF1015_RS02690 a cis- a 3-oxotetracosanoyl- a cis-delta19-3- a dipeptide HMPREF1015_RS05600 tetrahydrodipicolinate synthase: semialdehyde amino-acid L-tryptophan biosynthesis 2-aceto-2-hydroxy- an oleoyl-[acp] sn-glycerol sn-glycerol- γ formyl-L-methionine KDGP hydroxypimeloyl- MEP a 3- HMPREF1015_RS06285 hydroxybutanoate urea succinate semialdehyde vaccenoyl-[acp] terminal- -(L-ornithyl)-L-glutamate element IS30 [acp] oxo-C38:1-[acp] a 3-oxooctadecanoyl- 1-(5-phospho-β-D-ribosyl)- HMPREF1015_RS04065 HMPREF1015_RS04090 L-homoserine acetylornithine carbamoyl phosphate L-ornithine 3-phosphate 3-phosphate peptide deformylase: [acp] methyl ester RS14575 oxododecanoyl- reductase: ketol-acid acetyltransferase ArgJ: butanoate urease: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- acetylornithine 2-dehydro-3-deoxy- transposase: 3-oxoacyl-ACP 3-hydroxyacyl-[acyl- 3-oxoacyl-ACP 1-deoxy-D-xylulose- RS01535 [acp] 5-[(5-phosphoribosylamino) transaminase: HMPREF1015_RS10475 membrane dipeptidase: [acp] HMPREF1015_RS13140 reductoisomerase: HMPREF1015_RS08145 chorismate isomeroreductase: HMPREF1015_RS12045 succinate-semialdehyde phosphate acyltransferase: phosphate acyltransferase: transaminase: phosphogluconate HMPREF1015_RS01270 reductase FabG: carrier-protein] reductase FabG: 5-phosphate methylideneamino]imidazole- (2S)-2- homoserine O- HMPREF1015_RS08135 peptide deformylase: HMPREF1015_RS00690 3-oxoacyl-ACP 3-oxoacyl-ACP (S)-2,3,4,5- HMPREF1015_RS04070 HMPREF1015_RS04070 HMPREF1015_RS12050 dehydrogenase: gabD HMPREF1015_RS13350 HMPREF1015_RS13350 HMPREF1015_RS08135 aldolase: [+ 22 isozymes] HMPREF1015_RS02605 dehydratase FabZ: HMPREF1015_RS02605 reductoisomerase: isopropylmalate val succinyltransferase: hydrogencarbonate an [amino group carrier protein]- an insertion reductase FabG: reductase FabG: 4-carboxamide tetrahydrodipicolinate N-acetyl-L- anthranilate synthase: (R)-2,3-dihydroxy- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- HMPREF1015_RS09950 HMPREF1015_RS07315 [+ 4 isozymes] HMPREF1015_RS04605 [+ 4 isozymes] HMPREF1015_RS10885 (R)-2,3-dihydroxy- HMPREF1015_RS12055 γ an N-terminal L- D-glyceraldehyde a (3R)-3- a (2E)- a cis-delta19-3- a proteinogenic 1-deoxy-D- RS06305 HMPREF1015_RS02605 HMPREF1015_RS02605 1-(5-phosphoribosyl)-5- 3-isopropylmalate HMPREF1015_RS07000 ornithine succinate C-terminal- -(L-glutamate 5- formate sequence IS30 with citrate RS12175 citrate 2,3,4,5-tetrahydropyridine- 3-methylpentanoate carbamoyl- HMPREF1015_RS17565 3-methylpentanoate ammonium phosphate acyltransferase: phosphate acyltransferase: methionyl-[protein] pyruvate 3-phosphate hydroxytetracosanoyl- enoylpimeloyl- hydroxyC38:1- amino acid xylulose 5- [(5- phosphoribosylamino) dehydratase: ornithine HMPREF1015_RS07550 HMPREF1015_RS07550 semialdehyde-2-yl)-L-glutamate integrated transposon [+ 4 isozymes] [+ 4 isozymes] 2,6-dicarboxylate N- 2,3-dihydroxy-3- O-succinyl-L- phosphate synthase: acetylornithine 2,3-dihydroxy-3- 1-stearoyl-2- 1,2-dicis- [acp] [acp] methyl ester [acp] phosphate a (3R)-3- a (3R)-3- methylideneamino]imidazole- HMPREF1015_RS04050 cys carbamoyltransferase: anthranilate acetyltransferase: methylvalerate hydro-lyase: homoserine HMPREF1015_RS10405 deacetylase: methylvalerate hydro-lyase: acyl-carrier protein oleoyl-sn-glycerol acyl-carrier protein vaccenoyl- hydroxydodecanoyl- hydroxyoctadecanoyl- 4- carboxamide isomerase: HMPREF1015_RS04055 HMPREF1015_RS08520 HMPREF1015_RS06930 RS12875 HMPREF1015_RS09905 HMPREF1015_RS04085 HMPREF1015_RS10410 bifunctional anthranilate HMPREF1015_RS04085 3-phosphate phosphatidate RS10850 [acp] [acp] HMPREF1015_RS05610 aminotransferase 2-isopropylmaleate synthase component (S)-3-methyl-2- 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- phosphoribulosylformimino- L-2-acetamido-6- (S)-3-methyl-2- class V-fold PLP- carbamoyl L-ornithine II/anthranilate oxopentanoate oxoheptanedioate oxopentanoate dependent enzyme: phosphate 1-palmitoyl- a (3R)-3- a (3R)-3- 1498 a SpoIVB carrier-protein] carrier-protein] AICAR-phosphate 3-isopropylmalate a glutaryl-[acp] an [amino group carrier protein]-C- a [protein]- an organic a cis-delta17-3- a uracil HMPREF1015_RS12580 phosphoribosyltransferase: branched-chain-amino- a malonyl-[acp] sn-glycerol a myristoyl-[acp] 3'-dephospho- a carboxylic ester hydroxytetracosanoyl- hydroxyglutaryl- peptidase dehydratase FabZ: dehydratase FabZ: dehydratase: branched-chain-amino- methyl ester terminal-γ-(L-glutamyl)-L-glutamate L-cysteine hydroperoxide ATP oxo-C36:1-[acp] in 16S rRNA ornithine HMPREF1015_RS17565 acid transaminase: 3-phosphate peroxiredoxin: CoA carboxylesterase: [acp] [acp] methyl ester Precursor RS11405 RS06900 HMPREF1015_RS04605 HMPREF1015_RS04605 imidazole glycerol HMPREF1015_RS04050 acid transaminase: L-citrulline beta-ketoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- 3-oxoacyl-ACP 16S rRNA (uracil(1498)- HMPREF1015_RS04090 L-cystathionine carbamoyltransferase: N-(5-phosphoribosyl) HMPREF1015_RS04090 acetylglutamate kinase: HMPREF1015_RS05260 dephospho-CoA kinase: HMPREF1015_RS08680 a (2E)-dodec- a (2E)-octadec- phosphate synthase: HMPREF1015_RS04055 protein] synthase II: phosphate acyltransferase: carrier-protein] carrier-protein] reductase FabG: N(3))-methyltransferase: SpoIVB peptidase: HMPREF1015_RS06930 Secondary Metabolite Degradation HMPREF1015_RS08140 2-enoyl-[acp] N-acetyl-L,L-2,6- -anthranilate HMPREF1015_RS06285 HMPREF1015_RS13350 peroxiredoxin: HMPREF1015_RS15300 carboxylesterase: dehydratase FabZ: dehydratase FabZ: HMPREF1015_RS02605 HMPREF1015_RS14425 HMPREF1015_RS13860 2-enoyl-[acp] HMPREF1015_RS05605 (2R,3S)-3- argininosuccinate synthase: ile 3 diaminopimelate ile phosphoribosylanthranilate an [amino group carrier protein]- HMPREF1015_RS09915 HMPREF1015_RS05475 an N - HMPREF1015_RS05615 isopropylmalate β 3-oxoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- + HMPREF1015_RS04605 a (2E)- HMPREF1015_RS04605 a cis-delta17-3-[+ 4 isozymes] dodecanoyl-[acyl-carrier- L-cystathione -lyase: HMPREF1015_RS15445 γ an intra- ADP coenzyme A H methyluracil 1498 a SpoIVB RS01520 steroyl-[acp] reductase: N-acetyldiaminopimelate isomerase: anhydromuropeptides recycling I protein] reductase: phosphate acyltransferase: C-terminal- -(5-phospho- an alcohol a carboxylate an alcohol a (2E)-tetracos- RS15030 3-isopropylmalate HMPREF1015_RS12580 L-citrulline D-sorbitol degradation I protein disulfide enoylglutaryl- hydroxyC36:1- peptidase protein] reductase: HMPREF1015_RS06065 D-erythro- deacetylase: HMPREF1015_RS15875 L-isoleucine biosynthesis V L-glutamyl)-L-glutamate 2-enoyl-[acp] in 16S rRNA dehydrogenase: L-arginino-succinate GlcNAc-1,6- HMPREF1015_RS10560 HMPREF1015_RS075501-palmitoyl- [acp] methyl ester [acp] HMPREF1015_RS06065 AICAR imidazole-glycerol- HMPREF1015_RS09910 1-(o- a 3-oxopimeloyl- HMPREF1015_RS04060 2-aminoprop- anhMurNAc- D-sorbitol acyl-carrier protein acyl-carrier protein 2-myristoyl a stearoyl-[acp] phosphate L-homocysteine argininosuccinate synthase: argininosuccinate lyase: carboxyphenylamino) [acp] methyl ester a dodecanoyl-[acp] L,L- (2S)-2-isopropyl- 2-enoate 2-methylbutanoate L-Ala-γ-D-Glu- sorbitol dehydrogenase: phosphatidate RS14215 imidazoleglycerol- HMPREF1015_RS15445 HMPREF1015_RS15440 -1'-deoxyribulose RS09400 diaminopimelate 3-oxosuccinate L-cysteine biosynthesis acetate--CoA ligase: DAP-D-Ala HMPREF1015_RS07605 phosphate VI (from L-methionine) 5-methyltetrahydropteroyltriglutamate- L-arginino- 5'-phosphate diaminopimelate indole-3-glycerol HMPREF1015_RS15595 keto-D-fructose 4-(cytidine 5'- a (3R,7Z)-3- 3-oxoacyl-[acyl-carrier- dehydratase HisB: - homocysteine S-methyltransferase: methionine synthase: succinate arg 2-methylbutanoyl- Aromatic Compound a malonyl-[acp] an (R)-2- 5-cis, 7-trans-3-oxo- 3-oxo-(5Z)- (3E)-2-oxohex- epimerase: a malonyl-[acp] (S)-5-hydroxyisourate diphospho)-2-C- MEP CTP hydroxy-hexadec- a protein HMPREF1015_RS05620 HMPREF1015_RS06955 phosphate synthase TrpC: CoA Degradation a palmitoleoyl-[acp] a malonyl-[acp] halocarboxylate tetradecadienoyl-CoA tetradecenoyl-CoA 3-enedioate protein] reductase: HMPREF1015_RS12470 met HMPREF1015_RS12130 2-iminopropanoate argininosuccinate lyase: methyl ester stearate HMPREF1015_RS15880 beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl-carrier- HAD family hydrolase: acetyl-CoA C- acetyl-CoA C- methyl-D-erythritol4-(cytidine 5'- 2-C-methyl-D- 7-enoyl-[acp]3-hydroxyacyl-[acyl- 4-oxalocrotonate RS16125 HMPREF1015_RS10560 imidazole acetol- 4-methyl-2- methionine [+ 2 isozymes] HMPREF1015_RS15440 N-acetyl-β-D- L-alanyl-γ-D- hydroxyisourate hydrolase: RS03705 laurate meso- parathion degradation protein] synthase II: protein] synthase II: HMPREF1015_RS08660 acyltransferase: acyltransferase: diphospho)-2-C-methyl- erythritol 4-phosphate carrier-protein] decarboxylase: endopeptidase La: beta-ketoacyl-[acyl-carrier- phosphate oxopentanoate adenosyltransferase: (1S,2R)-1-C-(indol-3- glucosamine-1,6- glutamyl-meso-2,6- HMPREF1015_RS16040 long-chain fatty diaminopimelate β-D-fructofuranose HMPREF1015_RS06285 HMPREF1015_RS06285 HAD family hydrolase: HMPREF1015_RS04895 HMPREF1015_RS04895 D-erythritol kinase: cytidylyltransferase: dehydratase FabZ: HMPREF1015_RS04135 HMPREF1015_RS15040 protein] synthase II: histidinol-phosphate branched-chain-amino- HMPREF1015_RS06910 met yl)glycerol 3-phosphate anhydro-N-acetyl- diaminopimeloyl- long-chain fatty acid--CoA ligase: arg (S)-3-methyl-2- HMPREF1015_RS03960 [+ 2 isozymes] (S)-2-oxo-4- [+ 2 isozymes] HMPREF1015_RS00325 HMPREF1015_RS11735 HMPREF1015_RS04605 (2Z)-2- HMPREF1015_RS06285 diaminopimelate acid transaminase: SAM L-methionine salvage cycle I (bacteria and plants) tryptophan synthase: β-D-muramate D-alanine parathion 3-oxoacyl-[acyl-carrier- 3-oxoacyl-[acyl-carrier- an (S)-2- (3Z,5E)-dodeca- (3Z)-dodec- 2-phospho-4-(cytidine 4-(cytidine 5'- a (2E,7Z)- acid--CoA ligase: HMPREF1015_RS15180 transaminase: oxopentanoate a halide anion acetyl-CoA hydroxy-4-carboxy- acetyl-CoA hydroxypenta- RS02205 decarboxylase: HMPREF1015_RS04090 pyruvate HMPREF1015_RS15865 protein] reductase: protein] reductase: hydroxycarboxylate 3,5-dienoyl-CoA 3-enoyl-CoA 5'-diphospho)-2-C- diphospho)-2-C- hexadeca-2,7- a peptide HMPREF1015_RS15180 long-chain-fatty- HMPREF1015_RS13210 branched-chain-amino- 5-ureidoimidazoline 2,4-dienoate RS09375 HMPREF1015_RS13580 HMPREF1015_RS15870 HMPREF1015_RS10560 HMPREF1015_RS10560an (11Z)-3- methyl-D-erythritol methyl-D-erythritol dienoyl-[acp] a 3-oxotetradecanoyl- long-chain-fatty- acid--CoA ligase: L-histidinol met methionine acid transaminase: phosphotriesterase: a 3-oxoglutaryl- leu 2-oxoglutaramate tryptophan synthase γ F6P acyl-carrier protein acyl-carrier protein oxooctadec- [acp] acid--CoA ligase: HMPREF1015_RS11060 phosphate lys 2-oxo-4-methylthiobutanoate- adenosyltransferase: HMPREF1015_RS04090 1,6-anhydro-N- L-alanyl- -D- HMPREF1015_RS05950 [acp] methyl ester subunit beta: 11-enoyl-[acp] HMPREF1015_RS11060 glutamine aminotransferase: HMPREF1015_RS06910 acetyl-β-muramate glutamyl-meso- RS02065 3-oxoacyl-ACP stearoyl-CoA SAH 2-oxoglutaramate amidase: HMPREF1015_RS15870 HMPREF1015_RS07835 ile diaminopimelate reductase FabG: lauroyl-CoA superpathway of sulfate assimilation and cysteine biosynthesis HMPREF1015_RS07840 diethylthiophosphate 4-nitrophenol paraoxon degradation RS10140 1-stearoyl- an (S)-2- an all-trans 3-oxo- a (7Z)-3-oxo- 527 a (3R,5Z)-3- α HMPREF1015_RS02605 indole ser an acyl-[acyl- a (4Z)-hexadec- a guanine a [protein]- - 5'-methylthioadenosine/ sn-glycerol a malonyl-[acp] 2-oxoglutarate hexadec-7- hydroxy-tetradec- a protein 2-oxoglutarate halocarboxylate -retinyl ester myristoyl-CoA in 16S rRNA L-glutamate [+ 4 isozymes] histidinol S-adenosylhomocysteine 3-phospho-D-glycerate N-acetyl-D- paraoxon carrier protein] 3-phosphate 4-enoyl-[acp] HAD family hydrolase: 2-oxoglutarate carboxylesterase: acetyl-CoA C- 16S rRNA a (3R)-3- 4-(methylsulfanyl)-2-oxobutanoate SAM 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- enoyl-[acp] 5-enoyl-[acp]3-hydroxyacyl-[acyl- protein-glutamate O- RS14760 superpathway of L-serine nucleosidase: muramate 6- phosphotriesterase: HMPREF1015_RS08660 dehydrogenase HMPREF1015_RS08680 acyltransferase: 3-oxoacyl-ACP reductase: (guanine(527)-N(7))- hydroxytetradecanoyl- histidinol dehydrogenase: 3-phosphoglycerate tryptophan synthase phosphate acyltransferase: protein] synthase II: carrier-protein] methyltransferase CheR: GPR endopeptidase: and glycine biosynthesis I HMPREF1015_RS14570 phosphate HMPREF1015_RS05950 E1 component: HMPREF1015_RS01100 HMPREF1015_RS01645 methyltransferase RsmG: RS05210 biotin-carboxyl carrier protein assembly HMPREF1015_RS05625 S-adenosylmethionine subunit beta: HMPREF1015_RS07550 HMPREF1015_RS06285 HAD family hydrolase: carboxylesterase: dehydratase FabZ: HMPREF1015_RS13230 HMPREF1015_RS14470 [acp] dehydrogenase: L-proline biosynthesis I N-acetylmuramic acid diethylphosphate diethylphosphate 4-nitrophenol [+ 4 isozymes] 3-phospho- S-ribosyl-L- HMPREF1015_RS03960 HMPREF1015_RS15845 HMPREF1015_RS05475 [+ 2 isozymes] 7 HMPREF1015_RS05095 a [protein]-L- 3-hydroxyacyl-[acyl- HMPREF1015_RS09360 decarboxylase proenzyme: HMPREF1015_RS15870 6-phosphate etherase: 1-acyl-sn-glycerol-3- 3-oxoacyl-[acyl-carrier- a (3R,7Z)-3- an N - a (2E,5Z)- HMPREF1015_RS04605 phosphatidylglycerol an (S)-2- glutamate-O 5 carrier-protein] a [biotin carboxyl- histidinal D-glycerate homocysteine HMPREF1015_RS15290 phosphate acyltransferase: protein] reductase: a halide anion NADH CO succinyl-CoA a fatty acid all-trans-retinol acetyl-CoA lauroyl-CoA hydroxy-hexadec- methylguanine 527 a peptide RS07785 3-phosphoglycerate HMPREF1015_RS13740 hydroxycarboxylate 2 tetradeca-2,5- biosynthesis II (non-plastidic) carrier protein]-L-lysine 3-phosphooxypyruvate -methyl-ester dehydratase FabZ: dehydrogenase: S-ribosylhomocysteine glu N-acetyl-D- aHMPREF1015_RS13350 1-stearoyl 2- HMPREF1015_RS10560a (6Z)-3- 7-enoyl-[acp] in 16S rRNA dienoyl-[acp] biotin--[acetyl-CoA- histidinol dehydrogenase: lyase: 1,2-dihydroxy-5- dAdoMet trp glucosamine RS04250 HMPREF1015_RS04605 HMPREF1015_RS09360 3-phosphoserine glutamate 5-kinase: acyl-carrier protein acyl-sn-glycerol acyl-carrier protein oxooctadec- DHAP carboxylase] ligase: HMPREF1015_RS05625 HMPREF1015_RS02575 (methylsulfanyl)pent-1-en-3-one 6-phosphate a (2E)-tetradec- 3-phosphooxypyruvate aminotransferase: putrescine HMPREF1015_RS03010 3-phosphate 6-enoyl-[acp] NAD(P)H-dependent HMPREF1015_RS13120 2-hydroxy-3-keto-5- γ-L-glutamyl N-acetylglucosamine-6- RS07775 2-enoyl-[acp] glycerol-3-phosphate HMPREF1015_RS09355 spermidine synthase: a [biotin carboxyl-carrier his 3-phosphoserine L-homocysteine methylthiopentenyl-1- 5-phosphate phosphate deacetylase: dehydrogenase: HMPREF1015_RS04935 myristoyl-[acyl-carrier- 6 aminotransferase: phosphate phosphatase: an (R)-2- 3-oxo-(5Z)- 2251 966 a (3R,6Z)-3- protein]-N -biotinyl-L-lysine spermidine glutamate-5-semialdehyde HMPREF1015_RS05680 an acyl-[acyl- 2-amino-6-[1-hydroxyethyl]- cob(I)alamin- 2-oxoadipate guanosine a guanine a [protein]-L- RS14230 protein] reductase: HMPREF1015_RS13305 3-phospho-L-serine HMPREF1015_RS07825 a malonyl-[acp] hydroxyoctadec- a protein sn-glycerol HMPREF1015_RS09355 dehydrogenase: D-glucosamine carrier protein] 7-methyl-7,8-dihydropterin [corrinoid ATP halocarboxylate dodecenoyl-CoA in 23S rRNA in 16S rRNA methionine HMPREF1015_RS06065 2-hydroxy-5-(methylsulfanyl)- 3-oxoacyl-[acyl-carrier- 2-amino-4-hydroxy-6- 2-oxoglutarate HAD family hydrolase: acetyl-CoA C- 23S rRNA 16S rRNA 6-enoyl-[acp]3-hydroxyacyl-[acyl- peptide-methionine RS07750 3-phosphate 3-phospho- S-methyl-5'-thioadenosine HMPREF1015_RS03005 6-phosphate adenosyltranferase] HslU--HslV peptidase 3-oxopent-1-enyl 1-phosphate 5'-methylthioadenosine/ Alcohol Degradation protein] reductase: hydroxymethyldihydropteridine ATP:cob(I)alamin dehydrogenase HMPREF1015_RS08660 acyltransferase: (guanosine(2251)-2'-O)- (guanine(966)-N(2))- L-serine phosphoglucosamine carrier-protein] (R)-S-oxide reductase: ATPase subunit: a myristoyl-[acp] glycerol-3-phosphate 1- a [biotin carboxyl- S-adenosylhomocysteine L-glutamate-5- diphosphokinase: adenosyltransferase: E1 component: HAD family hydrolase: HMPREF1015_RS04895 methyltransferase RlmB: methyltransferase RsmD: L-arginine degradation L-cystathionine 2,3-diketo-5- HMPREF1015_RS10560 dehydratase FabZ: HMPREF1015_RS12335 O-acyltransferase PlsY: carrier-protein dimer]- nucleosidase: L-methionine biosynthesis III semialdehyde mutase: HMPREF1015_RS00165 adenosylcob(III)HMPREF1015_RS06820 HMPREF1015_RS15845 HMPREF1015_RS11705 HMPREF1015_RS10190 a protein-L- HMPREF1015_RS10685 methylthiopentyl-1- glycerol and glycerophosphodiester degradation beta-ketoacyl-[acyl-carrier- [1-(2-amino-7-methyl-4-oxo- HMPREF1015_RS03960 [+ 2 isozymes] 2-O- an N 2 - HMPREF1015_RS04605 RS13470 3-oxoacyl-[acyl-carrier- HMPREF1015_RS02910 N 6 -biotinyl-L-lysine I (arginase pathway) HMPREF1015_RS14570 HMPREF1015_RS12760 triphosphate alamin-[corrinoid an (R)-2- (3Z)-dec-3- a (2E,6Z)- ser glutaryl-CoA NADH CO a halide anion acetyl-CoA 2251 966 methionine- aminotransferase phosphate enolase: protein] synthase II: 7,8-dihydro-3H-pteridin- 2 methylguanosine methylguanine octadecadienoyl- a peptide RS16095 protein] reductase: a 1-acyl-sn acetyl-CoA carboxylase D-glucosamine adenosyltranferase] hydroxyacid enoyl-CoA (R)-S-oxide class V-fold PLP- HMPREF1015_RS07830 HMPREF1015_RS06285 6-yl)]ethyl diphosphate in 23S rRNA in 16S rRNA [acp] HMPREF1015_RS10560 -glycerol 3- acetyl-CoA biotin carboxylase subunit: arg L-homoserine 1-phosphate a glycerophosphodiester phosphate ser dependent enzyme: serine O-acetyltransferase: 5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate MTR homoserine O- acyl-carrier protein a 3-oxoacyl-[acp] beta-ketoacyl-[acyl-carrier- carboxylase carboxyl: HMPREF1015_RS01190 arginase: (S)-1-pyrroline- bifunctional UDP-N- glycerol 1-acyl-sn-glycerol-3- HMPREF1015_RS12580 HMPREF1015_RS11720 S-methyl-5- acetyltransferase: RS05425 protein] synthase II: HMPREF1015_RS15360 acetyl-CoA carboxylase HMPREF1015_RS01640 5-carboxylate acetylglucosamine phosphate acyltransferase: serine methylthioribulose 1- thioribose kinase: HMPREF1015_RS07000 glycerophosphodiester RS10095 HMPREF1015_RS06285 HMPREF1015_RS15365 biotin carboxylase subunit: cys O-acetyl-L- pyrroline-5- diphosphorylase/ HMPREF1015_RS07550 L-ornithine hydroxymethyltransferase: O-acetyl-L-serine phosphate dehydratase: HMPREF1015_RS07845 hydrogen sulfide glycerol kinase: phosphodiesterase: HMPREF1015_RS13915 hydrogen sulfide homoserine carboxylate reductase: glucosamine-1-phosphate 1-myristoyl- a (3R,5Z)-3- a (5Z)-3- a (3R,9Z)-3- a 3-oxohexadecanoyl- HMPREF1015_RS04730 HMPREF1015_RS07820 HMPREF1015_RS03670 HMPREF1015_RS13850 a (6S)-5- a [ThiI sulfur-carrier 4-trans-3-oxo- (-)-methyl a nucleoside histidinol 1-acyl-sn-glycerol-3- a [carboxyl-carrier HMPREF1015_RS13690 N-acetyltransferase GlmU: a myristoyl-[acp] sn-glycerol glu isobutanal cys hydroxy-tetradec- oxododec- hydroxy-octadec- [acp] O-acetylhomoserine formyltetrahydrofolate protein]-L-cysteine undecenoyl-CoA jasmonate diphosphate phosphate acyltransferase: protein dimer]-N 6 - gly HMPREF1015_RS00305 3-phosphate acetaldehyde acetyl-CoA C- carboxylesterase: 5-enoyl-[acp] 5-enoyl-[acp] 9-enoyl-[acp] RS01505 cysteine synthase A: ATP aminocarboxypropyltransferase/ sn-glycerol 1-acyl-sn-glycerol-3- bifunctional cysteine desulfurase: 3-hydroxyacyl-[acyl- nucleoside- RS06250 3-oxoacyl-ACP HMPREF1015_RS13350 carboxybiotinyl-L-lysine APS 5-(methylthio)ribulose 1-phosphate 5-MTR-1-P pro α dehydrogenase acyltransferase: HMPREF1015_RS08680 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: histidinol dehydrogenase: a 1,2-diacyl- HMPREF1015_RS00180 cysteine synthase: N-acetyl- -D- 3-phosphate phosphate acyltransferase: folylpolyglutamate synthase/ HMPREF1015_RS01035 carrier-protein] reductase FabG: HMPREF1015_RS04895 HMPREF1015_RS01645 HMPREF1015_RS01645 diphosphate kinase: HMPREF1015_RS05625 L-glutamate-5- S-adenosyl-L-methionine cycle I glucosamine HMPREF1015_RS13350 (acetylating): a [ThiI sulfur- [+ 2 isozymes] carboxylesterase: dehydratase FabZ: HMPREF1015_RS02605 sn-glycerol [+ 2 isozymes] adenylyl-sulfate kinase: sulfate adenylyltransferase: HMPREF1015_RS00720 glycerol-3-phosphate dihydrofolate synthase: [+ 4 isozymes] [+ 4 isozymes] HMPREF1015_RS13235 semialdehyde L-alanine biosynthesis I 1-phosphate HMPREF1015_RS04145 [+ 2 isozymes] HMPREF1015_RS05475 HMPREF1015_RS04605 3-phosphate HMPREF1015_RS02880 HMPREF1015_RS02885 1-acyl-sn-glycerol-3- HMPREF1015_RS14965 carrier protein]-S- ala 2-trans- a (5Z)-3-oxo- a (3R,5Z)-3- a (2E,9Z)- a nucleoside [+ 4 isozymes] dehydrogenase: a (6S)-5- + his phosphatidate L-glutamate gamma- S-methyl-5-thioribose-1- L-homocysteine bifunctional UDP-N- phosphate acyltransferase: H NADH isobutanoyl-CoA sulfanyl-L-cysteine acetyl-CoA MeOH (-)-jasmonate tetradec-5- hydroxydodec- octadeca-2,9- RS09295 RS13150 a (3R)-3- SAM 3-methyl-2- HMPREF1015_RS03665 formyltetrahydrofolate nonenoyl-CoA triphosphate hydroxyhexadecanoyl- cytidylyltransferase: semialdehyde cys PAPS APS phosphate isomerase: acetylglucosamine 1,2-dimyristoyl-HMPREF1015_RS07550 enoyl-[acp] 5-enoyl-[acp] dienoyl-[acp] oxobutanoate 5-methyltetrahydropteroyltriglutamate- uracil degradation I (reductive) [acp] HMPREF1015_RS10880 dehydrogenase: branched-chain-amino- HMPREF1015_RS07850 diphosphorylase/ DHAP acyl-carrier protein sn-glycerol - homocysteine S-methyltransferase: methionine synthase: a CDP- HMPREF1015_RS08870 methionine acid transaminase: glucosamine-1-phosphate 3-phosphate 3-hydroxyacyl-[acyl- superpathway of L-asparagine biosynthesis HMPREF1015_RS12130 HMPREF1015_RS06955 uracil nitrate RS09205 nitrate carrier-protein] diacylglycerol adenosyltransferase: HMPREF1015_RS04090 N-acetyltransferase GlmU: RS16075 glu [+ 2 isozymes] HMPREF1015_RS00305 dehydratase FabZ: CDP-diacylglycerol-- HMPREF1015_RS06910 val L-alanine biosynthesis III asp UDP-N-acetyl- a nascent peptidoglycan a peptidoglycan a nucleoside (5Z,8Z,11Z,14Z,17Z)-3- methyl (indol- sn-glycerol a (3R,11Z)-3- a [protein]- a nucleoside nitrate RS14095 nitrate HMPREF1015_RS04605 glycerol-3-phosphate 3- a ribonucleic acid a pectin met SAH met 5,6-dihydrouracil α-D-glucosamine with (L-alanyl-γ-D- with (L-alanyl-γ-D- a tRNA precursor CTP ATP oxodocosapentaenoyl-CoA 3-yl)acetate a malonyl-[acp] 3-phosphate hydroxyoctadec- L-arginine phosphatidyltransferase: triphosphate triphosphate a (2E)-hexadec- glutamyl-meso-2,6- glutamyl-meso-2,6- DNA-directed RNA 3-oxoacyl-[acyl-carrier- carboxylesterase: 11-enoyl-[acp]3-hydroxyacyl-[acyl- HMPREF1015_RS00730 5'-methylthioadenosine/ hydantoinase/oxoprolinase UDP-N-acetylglucosamine CCA tRNA pectin lyase: beta-ketoacyl-[acyl-carrier- glycerol-3-phosphate 1- protein arginine kinase: nucleoside a cation RS11090 a cation RS05685 2-enoyl-[acp] cys diaminopimeloyl-D- diaminopimeloyl-D- polymerase subunit omega: protein] reductase: HMPREF1015_RS08680 1-(3-sn- S-adenosylhomocysteine asparagine synthase asparagine synthase 1-carboxyvinyltransferase: L,D-transpeptidase: HMPREF1015_RS12165 O-acyltransferase PlsY: carrier-protein] triphosphatase YtkD: cysteine desulfurase: family protein: alanine) tetrapeptide nucleotidyltransferase: carboxylesterase: protein] synthase II: HMPREF1015_RS11760 palmitoyl-[acyl-carrier- 5-methyltetrahydropteroyltriglutamate- (glutamine-hydrolyzing): (glutamine-hydrolyzing): HMPREF1015_RS13795alanine) tetrapeptide HMPREF1015_RS10460 HMPREF1015_RS10560 HMPREF1015_RS02910 dehydratase FabZ: HMPREF1015_RS02120 phosphatidyl) nucleosidase: ala HMPREF1015_RS14665 HMPREF1015_RS04400 HMPREF1015_RS04655 a tRNA HMPREF1015_RS13125 an oligosaccharide with HMPREF1015_RS06285 a [protein]- protein] reductase: - homocysteine S-methyltransferase: HMPREF1015_RS06375 HMPREF1015_RS06905 [+ 4 isozymes] (3R,5Z,8Z,11Z,14Z,17Z)-3- HMPREF1015_RS05475 a 3- 1-C16:0-α,ω- HMPREF1015_RS04605 a cation RS02495 a cation -sn-glycerol HMPREF1015_RS14570 L,D-transpeptidase: containing a a (2E,11Z)- ω a nucleoside [+ 2 isozymes] UDP-N-acetylglucosamine a nascent peptidoglycan 4-deoxy-6-O-methyl-α- N -phospho- predicted HMPREF1015_RS06065 HMPREF1015_RS12130 3-ureidopropanoate a ribonucleic acid hydroxydocosapentaenoyl-CoA MeOH (indol-3-yl)acetate oxodocosanoyl- dicarboxyl-2- octadeca-2,11- 3-phosphate ala asparagine synthase asparagine synthase 1-carboxyvinyltransferase: HMPREF1015_RS00650 3' CCA end D-galact-4-enuronate end L-arginine diphosphate ABC [+ 2 isozymes] alanine racemase: with L,D cross links [acp] lysophosphatidate Zn 2+ Zn 2+ L-homocysteine S-ribosyl-L-homocysteine (glutamine-hydrolyzing): (glutamine-hydrolyzing): HMPREF1015_RS04825 D-ala dienoyl-[acp] a cation RS15895 a cation transporter a palmitoyl-[acp] phosphatidylglycerophosphatase HMPREF1015_RS09105 (meso-diaminopimelate Aminoacyl-tRNA Charging HMPREF1015_RS06905 HMPREF1015_RS06375 UDP-N-acetyl-α- of Zn2+ A: HMPREF1015_RS00950 containing) Peptide RS06245 Peptide an L-1- D-ala D-glucosamine- a cation RS08695 a cation phosphatidyl- tRNA charging enolpyruvate gln β 6 6 glutaminyl-tRNA S-ribosylhomocysteine lyase: asn asn -alanine Carboxylate Degradation an N -L- an O - 967 a (9Z)-3-oxo- a double-stranded 22 an organic Ca 2+ RS11230 Ca 2+ sn-glycerol UDP-N- a sulfurated a [protein]- an alkylated DNA decanoyl-CoA acetyl-CoA a cytosine an adenine a [protein]- biosynthesis via threonylcarbamoyladenine 37 methylguanine octadec-9- hydroperoxide a cation RS11910 a cation HMPREF1015_RS02575 acetylenolpyruvoylglucosamine [sulfur carrier] L-cysteine ATP cob(II)inamide in 16S rRNA oligonucleotide in tRNA L-tyrosine palmitate arg transamidation in tRNA in DNA DNA-3-methyladenine acetyl-CoA C- 16S rRNA enoyl-[acp] bifunctional thioredoxin-dependent glycine glycine reductase: pyruvate decarboxylation to acetyl CoA tRNA (N(6)-L- methylated-DNA-- tRNA (adenine(22)-N(1))- RS08425 arginine--tRNA ligase: ATP:cob(I)alamin glycosylase: acyltransferase: (cytosine(967)-C(5))- 3-oxoacyl-ACP reductase: oligoribonuclease/PAP thiol peroxidase: tyrosine protein kinase: betaine betaine long-chain fatty HMPREF1015_RS04920 HMPREF1015_RS01780 threonylcarbamoyladenosine(37) [protein]-cysteine S- methyltransferase TrmK: Cd 2+ RS03030 Cd 2+ an L-arginyl- glu a [pyruvate dehydrogenase adenosyltransferase: HMPREF1015_RS01540 HMPREF1015_RS01100 methyltransferase RsmB: HMPREF1015_RS01645 phosphatase NrnA: HMPREF1015_RS06810 HMPREF1015_RS07290 Arg Gln -C(2))- methylthiotransferase methyltransferase: a DNA containing HMPREF1015_RS14290 acid--CoA ligase: [tRNA ] glutamyl-tRNA UDP-N-acetyl- 1 E2 protein] N 6 -lipoyl-L-lysine HMPREF1015_RS06820 an alkylated [+ 2 isozymes] HMPREF1015_RS10485 [+ 4 isozymes] HMPREF1015_RS15405 N - [+ 3 isozymes] a [protein]- cyanate RS02235 cyanate HMPREF1015_RS15180 a tRNA Arg synthetase: α-D-muramate MtaB: HMPREF1015_RS14420a 2-methylsulfanyl-N 6 -L- HMPREF1015_RS01890 an apurinic/ 967 a (3R,9Z)-3- triphosphate adenosylcobinamide nucleobase 3-oxododecanoyl- a 5-methylcytosine a nucleoside 5'- 22 2+ 2+ pyruvate dehydrogenase an unsulfurated 37 a [protein]-S- methyladenine an alcohol L-tyrosine Cd RS11225 Cd HMPREF1015_RS11725 met 5'-deoxyadenosine threonylcarbamoyladenine a guanine in DNA apyrimidinic site hydroxy-octadec- long-chain-fatty- an L-glutamyl- dihydrolipoyl (acetyl-transferring) E1 [sulfur carrier] methyl-L-cysteine CoA in 16S rRNA monophosphate in tRNA phosphate a sugar RS04985 a sugar pyruvate in tRNA 9-enoyl-[acp] acid--CoA ligase: [tRNA Gln ] dehydrogenase: component subunit alpha: Co 2+ RS02490 Co 2+ HMPREF1015_RS11060 HMPREF1015_RS09970 HMPREF1015_RS09955 Asp-tRNA(Asn) UDP-N-acetyl- dihydrolipoyl an O 4 - UDP-α-D- trans-3'- all-trans- 6-methoxy-2-all- adenine 37 (2R,3S)-3- RS14145 palmitoyl-CoA cys /Glu-tRNA(Gln) α-D-muramoyl- a [protein]- an L-1-phosphatidyl- methylsalicylate hydrogen selenide a pimeloyl-[acp] trans-octaprenyl- val cysteine--tRNA ligase: L-alanyl-γ-D- dehydrogenase: O-acetyl-L-serine methylthymine ala glucuronate hydroxycotinine retinyl palmitate sn-glycerol in tRNA isopropylmalate gly fluoride RS00560 fluoride amidotransferase: L-cysteine UDP- 1 HMPREF1015_RS11715 HMPREF1015_RS13830 in DNA 8-amino-7- carboxylesterase: 1,4-benzoquinone carboxylesterase: tRNA1(Val) (adenine(37) 3-isopropylmalate an L-cysteinyl- HMPREF1015_RS08055 glutamyl-meso-2,6- acetate conversion O-acetylhomoserine methylated-DNA-- lipid kinase: demethylmenaquinone Cys glucuronosyltransferase: HMPREF1015_RS05475 HMPREF1015_RS08680 dehydratase: [tRNA ] aminocarboxypropyltransferase/ [protein]-cysteine S- oxononanoate synthase: -N6)-methyltransferase: glycine oxidase ThiO: gatA diaminopimelate a [pyruvate dehydrogenase to acetyl-CoA HMPREF1015_RS08460 HMPREF1015_RS00645 methyltransferase: fluoride RS00565 fluoride Cys a [pyruvate dehydrogenase E2 6 HMPREF1015_RS09825 carboxylesterase: carboxylesterase: HMPREF1015_RS00385 HMPREF1015_RS04050 HMPREF1015_RS07190 RS14150 a tRNA HMPREF1015_RS08065 E2 protein] N -S- cysteine synthase: methyltransferase: trans-3- HMPREF1015_RS13245 protein] N 6 -dihydrolipoyl-L-lysine 8-amino-7- HMPREF1015_RS08680 HMPREF1015_RS05475 an N 6 - HMPREF1015_RS04055 Aromatic Compound acetyldihydrolipoyl-L-lysine acetate HMPREF1015_RS00720 HMPREF1015_RS01890 acyl-carrier protein UDP hydroxycotinine- 1-(3-sn-phosphatidyl)- 3-methyl-6-methoxy- 2+ 2+ an L-glutaminyl- a [protein]-S- oxononanoate methyladenine 37 (2S)-2- glyoxylate Co Co Biosynthesis a thymine in DNA glucuronide palmitate all-trans-retinol sn-glycerol 3-phosphate 2-octaprenyl-1,4- MeOH salicylate 2+ RS09810 2+ Gln acetate--CoA ligase: acetate L-selenocysteine val isopropylmalate Mg Mg [tRNA ] methyl-L-cysteine benzoquinone in tRNA HMPREF1015_RS15595 1 RS13170 chorismate biosynthesis I gln lipoate acetyltransferase: acetyl-CoA Mg 2+ RS10055 Mg 2+ D-erythrose (6Z,9Z,12Z,15Z,18Z,21Z)-3- UDP-α-D- a uridine 38- acetyl-CoA HMPREF1015_RS09970 3-aci- sn-glycerol mycophenolate hexanoyl-CoA acetyl-CoA (S)-malate 4-phosphate an L-glutaminyl- oxotetracosahexaenoyl-CoA a stearoyl-[acp] glucuronate β-alanine phosphoenol 40 in tRNA thr D-ala nitropropanoate 3-phosphate dADP Mg 2+ RS09150 Mg 2+ [tRNA Gln ] nitronate monooxygenase: acetyl-CoA C- UDP- acetyl-CoA C- pyruvate RluA family fumarate hydratase: 3-deoxy-7- L-asparagine biosynthesis glycerol-3-phosphate 1- RS16085 a tRNA Gln HMPREF1015_RS02480 acyltransferase: glucuronosyltransferase: acyltransferase: 4-aminobutyrate--2- pseudouridine synthase: HMPREF1015_RS11245 phosphoheptulonate III (tRNA-dependent) O-acyltransferase PlsY: pyruvate kinase: threonine dehydratase: glycine oxidase ThiO: D-gluconate degradation HMPREF1015_RS08460 oxoglutarate transaminase: nitronate monooxygenase: HMPREF1015_RS04895 HMPREF1015_RS02910 mycophenolic HMPREF1015_RS01100 HMPREF1015_RS15350 HMPREF1015_RS10385 class II fumarate hydratase: HMPREF1015_RS09720 HMPREF1015_RS07190 a purine RS12980 a purine synthase: 1-stearoyl- HMPREF1015_RS02690 HMPREF1015_RS15625 asp HMPREF1015_RS09995 [+ 2 isozymes] UDP acid phenolic [+ 2 isozymes] [+ 3 isozymes] HMPREF1015_RS04020 D-gluconate [unspecified (4Z,7Z,10Z,13Z,16Z,19Z) acyl-carrier protein sn-glycerol 3-oxooctanoyl- dATP pyruvate a pseudouridine 38- aspartyl-tRNA Asn acetyl-CoA 3-oxopropanoate fumarate 2-oxobutanoate pyruvate 3-deoxy- degradation nitrite 3-oxopropanoate -docosahexaenoyl-CoA 3-phosphate glucuronide CoA 40 in tRNA a purine RS16030 a purine RS09265 synthetase: gluconokinase: D-arabino- glu products] HMPREF1015_RS14705 HMPREF1015_RS12090 heptulosonate an L-aspartyl- Inorganic Nutrient Metabolism D-gluconate acetate acetate 7-phosphate an L-glutamyl- Asn 6-phosphate RS08550 [tRNA ] UDP-α-D- (1S,2R)-1- (2Z)-2- [tRNA Glu ] O-acetyl-L- (6Z,9Z,12Z,15Z,18Z)-3- sn-glycerol (11Z,14Z,17Z)-3- a phosphate RS11175 3-dehydroquinate synthase: selenate reduction mycophenolate C-(indol-3- phosphoenol a cytosine in DNA hydroxypenta- roseoflavin a cation a cation a tRNA glu Asp-tRNA(Asn) methanethiol oxotetracosapentaenoyl-CoA a myristoyl-[acp] glucuronate oxoicosatrienoyl-CoA dGDP monoester HMPREF1015_RS13220 homoserine acetyl-CoA C- 3-phosphate UDP- ser pyruvate DNA cytosine 2,4-dienoate RS01515 /Glu-tRNA(Gln) O-acetylhomoserine glycerol-3-phosphate 1- yl)glycerol 3-oxoacyl-[acyl-carrier- bifunctional riboflavin urea cycle acyltransferase: glucuronosyltransferase: tryptophan synthase methyltransferase: 2-keto-4-pentenoate amidotransferase: selenate aminocarboxypropyltransferase/ 3-phosphate protein] reductase: pyruvate kinase: kinase/FAD synthetase: alkaline phosphatase: 3-dehydroquinate O-acyltransferase PlsY: hydratase: HMPREF1015_RS08055 HMPREF1015_RS04895 HMPREF1015_RS08460 subunit beta: HMPREF1015_RS15350 HMPREF1015_RS16540 HMPREF1015_RS10945 HMPREF1015_RS04560 sulfate adenylyltransferase: cysteine synthase: HMPREF1015_RS029101-myristoyl- mycophenolic HMPREF1015_RS10560 HMPREF1015_RS04150 RS07735 gatA [+ 2 isozymes] HMPREF1015_RS15870 [+ 5 isozymes] type II 3-dehydroquinate HMPREF1015_RS02885 arg HMPREF1015_RS00720 (4Z,7Z,10Z,13Z,16Z)- acyl-carrier protein sn-glycerol UDP acid O-acyl- D-glyceraldehyde (3R,11Z,14Z,17Z)-3- dGTP pyruvate a 5-methylcytosine (S)-4-hydroxy- roseoflavin HMPREF1015_RS08065 adenosine 5'- acetyl-CoA trp an alcohol RS07985 dehydratase: ile arginase: acetate met docosapentaenoyl-CoA 3-phosphate glucuronide 3-phosphate hydroxyicosatrienoyl-CoA in DNA 2-oxopentanoate 5'-phosphate isoleucine--tRNA ligase: phosphoselenate HMPREF1015_RS13975 an L-asparaginyl- HMPREF1015_RS01640 HMPREF1015_RS10370 an L-isoleucyl- [tRNA Asn ] Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis 3-dehydroshikimate [tRNA Ile ] argininosuccinate lyase: RS01500 ammonium a tRNA Ile HMPREF1015_RS15440 UDP-α-D- 3,5,3'-triiodo- a 2'- 3-oxo-4-pregnene- biotin RS03890 biotin (+)-7-epi-jasmonoyl-CoA acetyl-CoA sn-glycerol butanoyl-CoA acetyl-CoA [DNA] a D-hexose shikimate dehydrogenase: [2Fe-2S] iron-sulfur cluster biosynthesis aci-nitroethane a palmitoyl-[acp] glucuronate 2-hydroxyisobutyramide ethylphosphate superpathway of tetrahydrofolate biosynthesis menaquinol-6 biosynthesis thiamine salvage III pyridoxal 5'-phosphate biosynthesis I acyl carrier protein activation selenite carbamoyl- 3-phosphate L-thyronine deoxyribonucleoside 20-carboxyl-CoA HMPREF1015_RS14535 superpathway of menaquinol-7 biosynthesis menaquinol-8 biosynthesis thiamine formation from pyrithiamine and oxythiamine (yeast) nitronate monooxygenase: acetyl-CoA C- UDP- acetyl-CoA C- acetyl-CoA C- L-arginino- phosphate synthase: glycerol-3-phosphate 1- DNA polymerase/3'- glucokinase: L-ornithine HMPREF1015_RS02480 acyltransferase: glucuronosyltransferase: acyltransferase: amidase: deoxynucleoside kinase: acyltransferase: alkaline phosphatase: RS03925 D-erythrose succinate HMPREF1015_RS10405 O-acyltransferase PlsY: 5' exonuclease PolX: HMPREF1015_RS14135 RS04660 shikimate L-cysteine desulfurase demethylmenaquinol-6 thiamine an apo acyl- HMPREF1015_RS04895 HMPREF1015_RS08460 HMPREF1015_RS01100 HMPREF1015_RS13295 HMPREF1015_RS05275 HMPREF1015_RS04895 HMPREF1015_RS04560 chorismate demethylmenaquinol-8 pyrithiamine 4-phosphate coenzyme A HMPREF1015_RS10410 nitronate monooxygenase: HMPREF1015_RS029101-palmitoyl- 3,5,3'-triiodo-L- HMPREF1015_RS15190 leu GTP demethylmenaquinone carrier protein demethylmenaquinone thiamine diphosphokinase: holo-ACP synthase: HMPREF1015_RS09995 [+ 2 isozymes] UDP thyronine acyl [+ 2 isozymes] 2-hydroxy-2- a 2'- [+ 2 isozymes] D-hexose 6- shikimate kinase: leucine--tRNA ligase: cysteine desulfurase: methyltransferase: carbamoyl [unspecified 3-oxo-2-(cis-2'-pentenyl)- acyl-carrier protein sn-glycerol 3-oxohexanoyl- 3,22-dioxochol- a nucleoside 5'- isochorismate synthase: methyltransferase: HMPREF1015_RS10515 thiaminase II: HMPREF1015_RS09115 selenodiglutathione β-D-glucuronide methylpropanoate deoxyribonucleoside ethanol phosphate HMPREF1015_RS14040 HMPREF1015_RS15795 an L-leucyl- HMPREF1015_RS14665 HMPREF1015_RS13245 thiamine a holo acyl- phosphate degradation nitrite acetaldehyde cyclopentane-1-(3-oxobutanoyl)-CoA 3-phosphate CoA 4-en-24-oyl-CoA monophosphate HMPREF1015_RS02040 GTP cyclohydrolase I FolE: HMPREF1015_RS13245 HMPREF1015_RS08525 3',5'-ADP ornithine 5'-monophosphate RS14820 Leu carrier protein products] RS12345 [tRNA ] [+ 2 isozymes] menaquinol-6 diphosphate 4-phospho- carbamoyltransferase: shikimate 3- a tRNA Leu HMPREF1015_RS13260 menaquinol-8 4-amino-2-methyl-5- argininosuccinate synthase: an S-sulfanyl-[L- isochorismate D-erythronate HMPREF1015_RS06930 phosphate 7,8- pyrimidinemethanol HMPREF1015_RS15445 β cysteine desulfurase] a [2-oxoglutarate- UDP-α-D- C8-β-glucuronosyl- C12- - 3-oxo- ∆ 2 ∆ 4 1402 (2E,4E)- dihydroneopterin L-citrulline quinoxaline-2- UDP-α-D- trans- , cis- - a cytidine a ribonucleoside hexulose 6- 3-phosphoshikimate 1- 2-succinyl-5-enolpyruvyl-6- bifunctional dehydrogenase a sulfurated aryl-carrier protein α glucuronosyl- tetradeca-2,4- 3'-triphosphate glutathioselenol SAM glucuronate bilirubin-IX glucuronate palmitoyl-CoA decadienoyl-CoA in 16S rRNA 2'-phosphate biotin ATP phosphate sulfite RS09325 sulfite RS05300 carboxyvinyltransferase: hydroxy-3- cyclohexene-1- 6 carboxyl adenylate α hydroxymethylpyrimidine E2 protein] N - [sulfur carrier] UDP- bilirubin-IXUDP- acetyl-CoA C- 16S rRNA (cytosine(1402) dienoyl-CoA HMPREF1015_RS13200 carboxylic-acid synthase: (3R)-3-hydroxy-2-oxo- acyl carrier protein: 2,4-dienoyl-CoA reductase: 6-phospho-3- kinase/ sulfate reduction octanoyl-L-lysine lipoyl synthase: glucuronosyltransferase: glucuronosyltransferase: acyltransferase: -N(4))-methyltransferase: 2,4-dienoyl-CoA reductase: nucleotidase: biotin--[acetyl-CoA- 5-enolpyruvoyl- val 4 phosphooxybutanoate HMPREF1015_RS10565 HMPREF1015_RS15645 hexuloisomerase: valine--tRNA ligase: an S-sulfanyl-[cysteine HMPREF1015_RS02045 phosphomethylpyrimidine III (assimilatory) HMPREF1015_RS00985 HMPREF1015_RS08460 HMPREF1015_RS08460 HMPREF1015_RS01100 HMPREF1015_RS15645 HMPREF1015_RS14250 carboxylase] ligase: shikimate 3- a [2-oxoglutarate a quinoxaline-2- bis(β- bis(β- HMPREF1015_RS10255 HMPREF1015_RS07425 RS14245 desulfurase]-[disordered- 7,8- 3-phosphoserine/ an N 4 - HMPREF1015_RS13120 HMPREF1015_RS14970 an L-valyl- 2-succinyl-6-hydroxy- kinase: an unsulfurated dehydrogenase AMP carboxyl-[aryl- glucosyluronate) UDP glucosyluronate) UDP [+ 2 isozymes] (2E)-dec-2- biotinyl-5'- RS06265 phosphate 1402 (3E)-tetradec- Val form scaffold 2, 4-cyclohexadiene-1- dihydroneopterin HMPREF1015_RS13720 phosphohydroxythreonine hydrogen selenide sulfate 5'-deoxyadenosine met methylcytidine a ribonucleoside F6P [tRNA ] [sulfur carrier] E2 protein] N 6 carrier protein] bilirubin-IX α bilirubin-IX α myristoyl-CoA acetyl-CoA enoyl-CoA 3-enoyl-CoA adenylate chorismate synthase: Val protein] complex carboxylate synthase: 3'-phosphate transaminase: in 16S rRNA a tRNA flavin biosynthesis I (bacteria and plants) bifunctional sulfate adenylyltransferase: -lipoyl-L-lysine HMPREF1015_RS13225 [cysteine desulfurase]-S- HMPREF1015_RS02050 thiamine salvage II HMPREF1015_RS09355 sulfate activation hydroxymethylpyrimidine HMPREF1015_RS02885 taurine RS03465 taurine sulfanylcysteine:[acceptor 2-succinyl-5- 4-phosphooxy- for sulfonation kinase/ APS RS14565 chorismate protein]-cysteine 4-amino-2-methyl-5- a [pyruvate α a long-linear all-trans- enolpyruvoyl-6- GTP L-threonine D-glyceraldehyde a (3Z)-dec- UDP- -D- a nucleoside 3'- (2R,3S)-3- sulfurtransferase: 7,8- phosphomethylpyrimidine dehydrogenase a sulfurated N-acetyl-serotonin α-D-glucan octanoyl-CoA acetyl-CoA 4-guanidinobutyramide roseoflavin a nucleotide hydroxy-3-cyclohexene- chorismate pyrimidinemethanol 4-hydroxythreonine- pyruvate sulfate phosphoadenylyl- SAM a malonyl-[acp] glucuronate retinyl palmitate ATP monophosphate isopropylmalate dihydroneopterin kinase: 3-phosphate 6 3-enoyl-[acp] glycogen/starch/alpha- RS01160 ala HMPREF1015_RS14665 1-carboxylate sulfate adenylyltransferase: sulfate reductase: E2 protein] N - [sulfur carrier] beta-ketoacyl-[acyl-carrier- UDP- acetyl-CoA C- carboxylesterase: 5'-phosphate 3-isopropylmalate a [cysteine desulfurase]- bifunctional HMPREF1015_RS12490 4-phosphate glucan phosphorylase: nucleotidase: alanine--tRNA ligase: dihydroneopterin aldolase: aminodeoxychorismate/ bifunctional 3,4- 1-deoxy-D-xylulose-5- HMPREF1015_RS02890 octanoyl-L-lysine lipoyl synthase: glucuronosyltransferase: acyltransferase: amidase: HMPREF1015_RS08680 bifunctional riboflavin nucleotidase: S-sulfanyl-[disordered- 2-succinyl-6-hydroxy- hydroxymethylpyrimidine dehydrogenase PdxA: HMPREF1015_RS02885 protein] synthase II: dehydrogenase: RS09650 HMPREF1015_RS14635 an L-alanyl- HMPREF1015_RS00170 anthranilate synthase dihydroxy-2-butanone- phosphate synthase: HMPREF1015_RS08460 HMPREF1015_RS02030 HMPREF1015_RS01100 HMPREF1015_RS13295 kinase/FAD synthetase: HMPREF1015_RS14250 HMPREF1015_RS14250 2, 4-cyclohexadiene-1- kinase/ HMP-P HMPREF1015_RS12515 APS HMPREF1015_RS00985a [pyruvate HMPREF1015_RS06285a (5Z)-3- N-acetyl- α-D- carboxylesterase: HMPREF1015_RS04060 [tRNA Ala ] form scaffold component II: 4-phosphate synthase/ sulfite a long-linear HMPREF1015_RS10945 carboxylate synthase: 6-(hydroxymethyl) phosphomethylpyrimidine 3-amino-1- HMPREF1015_RS13880 an unsulfurated dehydrogenase UDP serotonin glucopyranose [+ 2 isozymes] HMPREF1015_RS05475 roseoflavin adenine 4-methyl-2- a tRNA Ala protein] complex HMPREF1015_RS04030 GTP cyclohydrolase II: acyl-carrier protein oxododec- α 3-oxodecanoyl- 4-guanidinobutanoate a nucleoside bifunctional 5'-deoxyadenosine met 6 -D-glucan a nucleoside RS02485 cysteine desulfurase: HMPREF1015_RS02050 -7,8-dihydropterin kinase: hydroxyacetone 1-deoxy-D-xylulose adenylyl-sulfate kinase: [sulfur carrier] E2 protein] N 5-enoyl-[acp] glucuronide 1-phosphate palmitate a retinol dinucleotide oxopentanoate (1R,6R)-6-hydroxy-2- 4-amino-4- HMPREF1015_RS12460 hydroxymethylpyrimidine CoA HMPREF1015_RS14665 2-amino-4-hydroxy-6- HMPREF1015_RS13720 1-phosphate 5-phosphate HMPREF1015_RS02880 -lipoyl-L-lysine RS00490 succinylcyclohexa-2,4- deoxychorismate 2,5-diamino-6-(5-phospho-D- kinase/ [+ 2 isozymes] hydroxymethyldihydropteridine oxythiamine an S-sulfanyl-[cysteine diene-1-carboxylate 4-amino-4- ribosylamino)pyrimidin-4(3H)-one bifunctional phosphomethylpyrimidine PAPS diphosphokinase: hydrogen sulfide undecaprenyl-diphospho-N asparagine- desulfurase]-S- o-succinylbenzoate deoxychorismate lyase: hydroxymethylpyrimidine kinase: a [release factor]- a nucleoside 5'- asn HMPREF1015_RS00165 bifunctional thiaminase II: γ α a (7Z)-hexadec- isovalerate palmitoleoyl-CoA 3-phenylpropionitrile an arylamine pyruvate RS06320 sulfanyl-[disordered- synthase: kinase/ HMPREF1015_RS13720 taurine degradation IV -acetylmuramoyl-L-alanyl- - UDP-N-acetyl- -D-glucosamine a malonyl-[acp] pimeloyl-CoA ala L-glutamine -tRNA (7,8-dihydropterin- HMPREF1015_RS04025 diaminohydroxyphosphoribosylaminopyrimidine HMPREF1015_RS08525 7-enoyl-[acp] 4'-phosphopantetheine ATP monophosphate form scaffold HMPREF1015_RS12675 phosphomethylpyrimidine D-glutamyl-L-lysyl- D-alanine acetate--CoA ligase: peptide chain release RS04760 ligase: asnC an L-asparaginyl- 6-yl)methyl deaminase/5-amino-6-(5-phosphoribosylamino) pyridoxine 5'-phosphate undecaprenyldiphospho- beta-ketoacyl-[acyl-carrier- 8-amino-7- acyl-CoA dehydrogenase: arylamine N- 4-aminobenzoate kinase: 5-(2-hydroxyethyl) bifunctional HMPREF1015_RS15595 pantetheine-phosphate factor N(5)-glutamine nitrilase: nucleotidase: pyruvate carboxylase: Asn protein] complex muramoylpentapeptide beta-N- protein] synthase II: oxononanoate synthase: HMPREF1015_RS01200 acetyltransferase: [tRNA ] [cysteine desulfurase]-S- 2-succinylbenzoate diphosphate uracil reductase RibD: HMPREF1015_RS12450 hydroxymethylpyrimidine taurine HMPREF1015_RS07470 HMPREF1015_RS10100 Asn HMPREF1015_RS12490 -4-methylthiazole acetylglucosaminyltransferase: HMPREF1015_RS06285 adenylyltransferase: methyltransferase: HMPREF1015_RS14250 HMPREF1015_RS04125 tRNA sulfanylcysteine:[acceptor 5-amino-6-(5-phospho- kinase/ glyphosate degradation II a (9Z)-3-oxo- HMPREF1015_RS09825 [+ 5 isozymes] hydroxyethylthiazole taurine dioxygenase: isovaleryl-CoA AMP diphosphate 8-amino-7- HMPREF1015_RS10195 HMPREF1015_RS04785 o-succinylbenzoate- ditrans,octacis-undecaprenyldiphospho-HMPREF1015_RS10300 acyl-carrier protein octadec-9- coenzyme A 3'-dephospho- (2E,9Z)- 5 an N- RS09450 protein]-cysteine dihydropteroate synthase: D-ribosylamino)uracil HMP-P phosphomethylpyrimidine HMPREF1015_RS03435 oxononanoate a [release factor]-N 3-phenylpropanoate a nucleoside oxaloacetate RS10640 -CoA ligase: kinase: UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- enoyl-[acp] CoA hexadecenoyl-CoA acetylarylamine sulfurtransferase: HMPREF1015_RS00175 bifunctional kinase: glyphosate -methyl-L-glutamine HMPREF1015_RS12495 2-aminoacetaldehyde γ HMPREF1015_RS14665 HMPREF1015_RS02060 bifunctional HMPREF1015_RS12490 PLP glycine oxidase ThiO: L-alanyl- -D-glutamyl-L-lysyl-D-alanine a [cysteine diaminohydroxyphosphoribosylaminopyrimidine 4-methyl-5-(2- 4-(2'-carboxyphenyl) 7,8- D-ribulose 5-phosphate hydroxymethylpyrimidine HMPREF1015_RS07190 asp desulfurase]-(S- deaminase/5-amino-6-(5-phosphoribosylamino) phosphooxyethyl) dihydropteroate kinase/ HMP-PP aminomethylphosphonate 2503 aspartate--tRNA ligase: sulfanyl) -[disordered- -4-oxobutyryl-CoA uracil reductase RibD: HMPREF1015_RS12450 glyoxylate adenine a [DNA]-3'- a 5'-phospho- a single- (7Z)- 2-trans, 4-trans 7,8- RS14295 2 bifunctional 3,4- thiazole a (5Z)-tetradec- + an unsulfurated β-D-allopyranose RS11740 HMPREF1015_RS14705 1,4-dihydroxy-2- bifunctional phosphomethylpyrimidine a malonyl-[acp] NAD cys -undecadienoyl- 2-chloroacetate ferroheme o an L-aspartyl- form scaffold dihydroxy-2-butanone- 5-amino-6-(5-phospho- in 23S rRNA 5-enoyl-[acp] hydroxyl [DNA] stranded RNA [sulfur carrier] hexadecenoyl-CoA diaminopelargonate asp folylpolyglutamate synthase/ kinase: 23S rRNA polyribonucleotide CoA D-ribose pyranase: [tRNA ] protein] complex naphthoyl-CoA synthase: 4-phosphate synthase/ D-ribitylamino)uracil thiamine phosphate beta-ketoacyl-[acyl-carrier- DNA ligase D: cysteine desulfurase: acyl-CoA dehydrogenase: haloacid asp (2E,6E)-farnesyl dihydrofolate synthase: HMPREF1015_RS13720 (adenine(2503)-C(2))- nucleotidyltransferase: dethiobiotin synthase: HMPREF1015_RS04990 heme A synthase: tRNA IPP HMPREF1015_RS02055 GTP cyclohydrolase II: synthase: protein] synthase II: HMPREF1015_RS12475 HMPREF1015_RS01035 HMPREF1015_RS01200 2,4-dienoyl-CoA reductase: dehalogenase type II: diphosphate HMPREF1015_RS14965 HMPREF1015_RS12500 methyltransferase RlmN: HMPREF1015_RS10955 HMPREF1015_RS15645 HMPREF1015_RS07230 D-ribose pyranase: HMPREF1015_RS10105 1,4-dihydroxy-2- HMPREF1015_RS12460 5-(2-hydroxyethyl) bifunctional superpathway of thiamine diphosphate biosynthesis II aHMPREF1015_RS06285 (7Z)-3-oxo- [+ 2 isozymes] [+ 5 isozymes] HMPREF1015_RS08785 RS00735 RS09380 7,8-dihydrofolate HMPREF1015_RS10490 NMN AMP [DNA] a nucleoside a single- a sulfurated HMPREF1015_RS16865 heptaprenyl diphosphate naphthoyl-CoA -4-methylthiazole hydroxymethylpyrimidine acyl-carrier protein hexadec-7- ala (2E,7Z)- (3E)-undec- a [cysteine desulfurase]- 1-deoxy-L-glycero- a 2-methyladenine 2503 diphosphate stranded RNA [sulfur carrier] dethiobiotin glycolate ferroheme a synthase component II: monoglutamate kinase/ thiamine 5'-deoxyadenosine met hexadecenoyl-CoA β-D-allofuranose [scaffold protein- tetrulose 4-phosphate ARP hydroxyethylthiazole enoyl-[acp] 3-enoyl-CoA HMPREF1015_RS13240 phosphomethylpyrimidine a ThiS sulfur- cys in 23S rRNA (2Fe-2S)] complex kinase: phosphate tyr kinase: carrier protein RS11920 tyrosine--tRNA ligase: all-trans-heptaprenyl HMPREF1015_RS12495 Nucleoside and Nucleotide Degradation 2-carboxy-1,4- 6,7-dimethyl-8- HMPREF1015_RS12490 cysteine desulfurase: RS11460 HMPREF1015_RS15590 an L-tyrosyl- diphosphate 4-methyl-5-(2- ThiS adenylyltransferase: a 2,3,4-saturated β α 34 naphthoquinol ribityllumazine synthase: HMPREF1015_RS14665 a 2-oxo a -Gal-(1->3)- -Gal-(1->2) MoO - (5Z)- an N-hydroxy- an adenosine Tyr a 7,8-dihydrofolate a (3Z)-dodec- 2 [tRNA ] phosphooxyethyl) HMPREF1015_RS07205 CTP 1,2-diacyl-sn- α 5-aminolevulinate Arg2 chorismate a [co-chaperone]- HMPREF1015_RS12465 HMP-PP [+ 2 isozymes] superpathway of pyrimidine carboxylate a malonyl-[acp] -[ -(1->6)-oligomannan] DL-allothreonine molybdopterin ATP dodecenoyl-CoA arylamine in [tRNA ] a tRNA Tyr thiazole inosine 5'-phosphate 3-enoyl-[acp] 1,4-dihydroxy-2-naphthoate AIR a carboxy- an [L-cysteine deoxyribonucleosides degradation 2-oxoacid ferredoxin beta-ketoacyl-[acyl-carrier- glycerol 3-phosphate polysaccharide pyruvyl serine acyl-CoA dehydrogenase: arylamine N- tRNA adenosine(34) [scaffold protein- dihydrofolate reductase: degradation phosphatidate porphobilinogen synthase: cofactor molybdenum cofactor chorismate mutase: RS01720 heptaprenyltransferase: adenylated-[ThiS desulfurase]-S- oxidoreductase protein] synthase II: transferase CsaB: hydroxymethyltransferase: HMPREF1015_RS01200 acetyltransferase: deaminase TadA: (2Fe-2S)] complex HMPREF1015_RS12275 6,7-dimethyl-8-(1-D-ribityl)lumazine 2'-deoxycytidine cytidylyltransferase: RS04255 thiamine phosphate sulfur-carrier protein] sulfanyl-L-cysteine subunit beta: HMPREF1015_RS08105 HMPREF1015_RS15005 guanylyltransferase: HMPREF1015_RS13215 SSQ1 chaperone: HMPREF1015_RS02035 D-glyceraldehyde aHMPREF1015_RS06285 (5Z)-3-oxo- HMPREF1015_RS10880 HMPREF1015_RS04730 [+ 5 isozymes] HMPREF1015_RS04125 HMPREF1015_RS00035 synthase: gly HMPREF1015_RS00680 a CDP-2,3,4-saturated- a 4,6-CH (COO-)C-β-Gal-(1->3)-α- adenylyl HMPREF1015_RS09685 a tetrahydrofolate 3-phosphate IMP a reduced 3 an N- an inosine 34 HMPREF1015_RS14440 riboflavin synthase: HMPREF1015_RS12500 cytidine deaminase: acyl-carrier protein tetradec-5- gly acetaldehyde porphobilinogen molybdenum (2E,5Z)- prephenate cysteine desulfurtrase: + diacylglycerol Gal-(1->2)-[α-(1->6)-oligomannan] Arg2 trp RS06570 trp Trp demethylmenaquinol-7 HMPREF1015_RS12455 1-deoxy-D-xylulose-5- H ferredoxin [iron- CO an acyl-CoA enoyl-[acp] dodecenoyl-CoA acetoxyarylamine in [tRNA ] a tRNA a [chaperone-ATP]- HMP-P HMPREF1015_RS15555 HMPREF1015_RS02285 IMP dehydrogenase: 2 cofactor tryptophan--tRNA ligase: glycine oxidase ThiO: phosphate synthase: sulfur] cluster [co-chaperone]- thiamine thymidine HMPREF1015_RS00070 RS02535 serine serine HMPREF1015_RS06255 an L-tryptophanyl- demethylmenaquinone riboflavin HMPREF1015_RS07190 HMPREF1015_RS13880 RS16180 [scaffold protein- thiamine salvage IV (yeast) phosphate bifunctional 2'-deoxyuridine thr Trp a thiocarboxy- thr [tRNA ] methyltransferase: 1-deoxy-D-xylulose pyrimidine- XMP (2Fe-2S)] complex hydroxymethylpyrimidine 2-iminoacetate decaprenyl-diphospho-N- UDP-N-acetyl- a peptide with a single 2-trans, 4-cis- 3-amino-4- an organic trp HMPREF1015_RS13245 bifunctional riboflavin [ThiS-Protein] a cis- sn-glycerol an N-modified glycerophosphoserine serine serine kinase/ 5-phosphate nucleoside acetylmuramoyl-pentapeptide α-D-glucosamine an N-terminal undecadienoyl- a 7,8-dihydrofolate DMK-12 RS16185 thiamine kinase/FAD synthetase: aminoacyl-[tRNA] stranded DNA hydroxybenzoate molecule thr thr SSQ1 chaperone ATPase: phosphomethylpyrimidine phosphorylase: bifunctional undecaprenyldiphospho- vaccenoyl-[acp] 3-phosphate glycerophosphodiester CoA menaquinol-7 HMPREF1015_RS10945 glycerol-3-phosphate 1- Xaa-L-proline arylamine N- demethylmenaquinone RS06345 HMPREF1015_RS14440 thiazole synthase: pyrimidine- deoA metallophosphatase/ muramoylpentapeptide beta-N- aminoacyl-tRNA hydrolase: leucyl aminopeptidase: deoxyribonuclease IV: phosphodiesterase: dihydrofolate reductase: cytochrome P450: thiamine kinase: O-acyltransferase PlsY: 2,4-dienoyl-CoA reductase: acetyltransferase: methyltransferase: thiaminase II: 5'-nucleotidase: HMPREF1015_RS00290 HMPREF1015_RS05725 HMPREF1015_RS14265 HMPREF1015_RS12275 FMN diphosphate HMPREF1015_RS13720 HMPREF1015_RS07200 nucleoside acetylglucosaminyltransferase: a peptide with HMPREF1015_RS13850 HMPREF1015_RS15645 HMPREF1015_RS05825 RS13645 a [chaperone- HMPREF1015_RS08525 thymine HMPREF1015_RS01000 HMPREF1015_RS029101-cis-vaccenoyl- an N-modified an uncharged a proteinogenic HMPREF1015_RS04125 HMPREF1015_RS13245 an [2Fe-2S] phosphorylase: HMPREF1015_RS10300 an N-terminal sn-glycerol thr ADP]-[disordered- bifunctional riboflavin bifunctional 2-[(2R,5Z)-2-carboxy- decaprenyl-pyrophosphoryl- acyl-carrier protein sn-glycerol- amino acid tRNA amino acid ser (3E)-undec- 3-acetylamino-4- threonine--tRNA ligase: cluster protein deoA [+ 2 isozymes] L-proline a 5'-phosphooligonucleotide 3-phosphate a folate menaquinol-12 an alcohol form scaffold 4-amino-2-methyl-5- 5-(2-hydroxyethyl) kinase/FAD synthetase: hydroxymethylpyrimidine 4-methylthiazol-5(2H)- UDP (N-acetylglucosamine)-N- 3-phosphate 3-enoyl-CoA hydroxybenzoate HMPREF1015_RS15260 an L-threonyl- RS13585 protein] complex pyrimidinemethanol -4-methylthiazole HMPREF1015_RS10945 kinase/ ylidene]ethyl phosphate acetylmuramyl-(pentapeptide) [tRNA Thr ] xanthosine 10 phosphomethylpyrimidine RS15560 Thr non-chaperonin molecular hydroxyethylthiazole N -formyl-tetrahydrofolate biosynthesis molybdenum cofactor biosynthesis a tRNA bifunctional FAD kinase: chaperone ATPase: kinase: uracil 2-deoxy-α- α hydroxymethylpyrimidine purine-nucleoside 3-oxo-2-(cis-2'-pentenyl)- α 3,5,3'-triiodo- (5Z,8Z,11Z,14Z,17Z) UDP- -D- (Z,Z)- (7Z)- HMPREF1015_RS14440 HMPREF1015_RS12490 D-ribose 1- acetyl-CoA UDP- -D-glucuronate an apo [peptidyl- H O diphosphate a uridine in tRNA wound RNA DMKH2-13 acetamide kinase/ HMPREF1015_RS12495 a tetrahydrofolate 2-(2-carboxy-4- phosphorylase: cyclopentane-1-hexanoyl-CoA L-thyronine -icosapentaenoyl-CoA coenzyme A glucuronate bilirubin-IX α 2 tetradecenoyl-CoA 4-methyl-5-(2- phosphate carrier protein] UDP- RS03410 an [Fe-S cluster a [disordered- NAD biosynthesis methylthiazol-5- GTP acetyl-CoA C- UDP- acyl-CoA thioesterase: inorganic acyl-CoA dehydrogenase: demethylmenaquinone phosphomethylpyrimidine HMP-PP cys ATP HMPREF1015_RS12380 holo-ACP synthase: tRNA dihydrouridine RS02355 biosynthesis form [Fe-S] cluster I (from aspartate) phosphooxyethyl) yl)ethyl phosphate phosphopentomutase: acyltransferase: glucuronosyltransferase: HMPREF1015_RS11040 glucuronosyltransferase: DNA/RNA helicase: amidase: kinase: HMPREF1015_RS09115 pyrophosphatase: HMPREF1015_RS01200 synthase DusB: methyltransferase: chaperone]-ATP scaffold protein] thiazole HMPREF1015_RS13625 xanthine HMPREF1015_RS04895 HMPREF1015_RS08460 [+ 2 isozymes] HMPREF1015_RS08460 HMPREF1015_RS09520 HMPREF1015_RS13295 ser HMPREF1015_RS13720 3,5,3'-triiodo-L- a holo [peptidyl- C12-β- HMPREF1015_RS13510 [+ 5 isozymes] HMPREF1015_RS00155 HMPREF1015_RS13245 serine--tRNA ligase: thiamine phosphate dihydrofolate reductase: methionine synthase: thiamine phosphate cysteine desulfurase: GTP 3',8-cyclase MoaA: (5Z,8Z,11Z,14Z,17Z) 3',5'-ADP 2-deoxy-D-ribose [+ 2 isozymes] UDP thyronine phenolic coenzyme A UDP glucuronosyl- phosphate H + (2E,7Z)- a 5,6-dihydrouridine HMPREF1015_RS00050 an L-seryl- asp bifunctional HMPREF1015_RS06955 HMPREF1015_RS14665 HMPREF1015_RS10995 xanthine dehydrogenase 3-oxo-2-(cis-2'-pentenyl)- -icosapentaenoate carrier protein] synthase: HMPREF1015_RS12275 synthase: β α an unwound RNA menaquinol-13 acetate RS09615 ser hydroxymethylpyrimidine [+ 2 isozymes] (8S)-3',8-cyclo-7,8- 5-phosphate subunit D: -D-glucuronide bilirubin-IX tetradecenoyl-CoA in tRNA RS15065 [tRNA ] L-aspartate oxidase: HMPREF1015_RS12500 superpathway of heme b biosynthesis HMPREF1015_RS12500 cyclopentane-1-(3-oxooctanoyl)-CoA a tRNA ser HMPREF1015_RS14855 kinase/ an [L-cysteine a carboxy-adenylated dihydroguanosine HMPREF1015_RS16050 heme b biosynthesis I (aerobic) thiamine from uroporphyrinogen-III desulfurase]-S- [small subunit of deoxyribose- 2-iminosuccinate phosphomethylpyrimidine 5'-triphosphate xanthine dehydrogenase: phosphate sulfanyl-L-cysteine molybdopterin synthase] phosphate aldolase: a (1->4)- kinase: thiamine phosphate cyclic pyranopterin HMPREF1015_RS16055 RNase III mRNA (5Z)- (3E)-5-chloro-2- uroporphyrinogen-III isobutanoate a tRNA precursor α-D-glucan glycerophosphoglycerol prephenate DMKH2-10 acrylamide uroporphyrinogen-III quinolinate synthase NadA: HMPREF1015_RS12490 monophosphate HMPREF1015_RS02280 processing substrate 2-oxoglutarate D-ala tetradecenoyl-CoA oxopent-3-enoate RS13155 RS16425 uroporphyrinogen serine ribonuclease III: acetate--CoA ligase: glycogen/starch/alpha- glycerophosphodiester HMPREF1015_RS14845 uroporphyrinogen synthase MoaC: urate ribonuclease Z: D-amino-acid transaminase: acyl-CoA dehydrogenase: 2-keto-4-pentenoate demethylmenaquinone decarboxylase: HMP-P a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate D-glyceraldehyde HMPREF1015_RS10570 HMPREF1015_RS15595 glucan phosphorylase: phosphodiesterase: prephenate dehydratase: amidase: pro decarboxylase: HMPREF1015_RS07720 acetaldehyde HMPREF1015_RS13700 HMPREF1015_RS01200 hydratase: methyltransferase: proline--tRNA ligase: HMPREF1015_RS04730 3-phosphate HMPREF1015_RS15725 HMPREF1015_RS02030 HMPREF1015_RS13850 HMPREF1015_RS14870 HMPREF1015_RS13295 HMPREF1015_RS06520 quinolinate thiamine HMPREF1015_RS06520 a thiocarboxylated ribonuclease III: a single-stranded α-D- [+ 5 isozymes] HMPREF1015_RS04150 HMPREF1015_RS13245 HMPREF1015_RS10895 an L-prolyl- coproporphyrinogen III bifunctional [small subunit of cyclic pyranopterin isobutanoyl-CoA AMP diphosphate mature tRNA pyruvate D-glt a (1->4)- sn-glycerol thiamine diphosphate acetaldehyde HMPREF1015_RS11710 oligoribonucleotide glucopyranose glycerol (2E,5Z)- 5-chloro-4-hydroxy- keto- RS03190 RS12430 Pro nicotinate-nucleotide hydroxymethylpyrimidine coproporphyrinogen III thymidylate synthase: phosphate RNase III processing α-D-glucan 3-phosphate menaquinol-10 acrylate [tRNA ] thiamine diphosphokinase: molybdopterin synthase] dehydrogenase an mRNA fragment 1-phosphate tetradecenoyl-CoA 2-oxopentanoate phenylpyruvate a tRNA Pro diphosphorylase kinase/ product mRNA HMPREF1015_RS10515 HMPREF1015_RS12270 (acetylating): (carboxylating): phosphomethylpyrimidine bifunctional a (6S)-5- HMPREF1015_RS04145 HMPREF1015_RS14850 kinase: thiamine methylenetetrahydrofolate formyltetrahydrofolate 5,10- 3-oxo-2-(cis-2'-pentenyl)- 5-amino-4- an apo-[LYS2 L- UDP-α-D- a [protein]-L- protoporphyrinogen IX HMPREF1015_RS13720 diphosphate acetyl-CoA L-carnitine PRPP L-thyroxine an L-cysteinyl- cis-vaccenoyl-CoA a DNA segment DMKH2-11 (R)-lactate RS06830 RS06755 methylenetetrahydrofolate dehydrogenase/ 5-formyltetrahydrofolate phosphopantothenate biosynthesis I acetyl-CoA 2-aminoadipyl- coenzyme A glucuronate NaMN molybdopterin cyclopentane-1-butanoyl-CoA imidazolecarboxyamide [tRNA Cys ] proline (ω = 180) phenylalanine--tRNA ligase: bifunctional protoporphyrinogen IX protoporphyrinogen IX methenyltetrahydrofolate cyclo-ligase: siroheme biosynthesis acetyl-CoA C- carnitine-CoA ligase: adenine UDP- phe protoporphyrinogen reductase: carrier-protein] holo-ACP synthase: aminoacyl-tRNA hydrolase: acyl-CoA dehydrogenase: peptidyl-prolyl cis- demethylmenaquinone D-2-hydroxyacid HMPREF1015_RS15210 nicotinate-nucleotide hydroxymethylpyrimidine cyclohydrolase FolD: HMPREF1015_RS14165 3-methyl-2- acyltransferase: phosphoribosyltransferase: glucuronosyltransferase: recombinase RecA: oxidase: HMPREF1015_RS06950 lipoate biosynthesis and HMPREF1015_RS00420 HMPREF1015_RS09115 HMPREF1015_RS01200 trans isomerase: methyltransferase: dehydrogenase: HMPREF1015_RS13900 oxobutanoate HMPREF1015_RS04895 HMPREF1015_RS14735 a holo-[LYS2 L- HMPREF1015_RS08460 HMPREF1015_RS00290 HMPREF1015_RS00710 met RS01065 met HMPREF1015_RS15215 an L-phenylalanyl- HMPREF1015_RS06510 adenylyltransferase: kinase/ a 5,10- a 5,10- uroporphyrinogen-III incorporation III (Bacillus) L-thyroxine [+ 5 isozymes] HMPREF1015_RS08910 HMPREF1015_RS13245 HMPREF1015_RS06815 protoporphyrinogen Cys Phe HMPREF1015_RS14525 phosphomethylpyrimidine methylenetetrahydrofolate methenyltetrahydrofolate uroporphyrinogen-III 3-methyl-2-oxobutanoate [+ 2 isozymes] diphosphate AMP L-carnitinyl-CoA 2-aminoadipyl- 3',5'-ADP a tRNA cys RS05450 [tRNA ] heme a biosynthesis oxidase: superpathway of purine deoxyribonucleosides degradation AICAR UDP phenolic β-D- (2E,11Z)- a DNA segment in a [protein]-L- Phe protoporphyrin IX hydroxymethyltransferase: molybdopterin 3-oxo-2-(cis-2'-pentenyl)- carrier-protein] menaquinol-11 pyruvate a tRNA nicotinate adenine kinase: bifunctional C-methyltransferase: an octanoyl-[acp] glucuronide octadecenoyl-CoA reverse orientation proline (ω = 0) HMPREF1015_RS06510 HMPREF1015_RS13115 adenine dinucleotide cyclopentane-1-(3-oxohexanoyl)-CoA RS11190 dinucleotide HMPREF1015_RS12490 methylenetetrahydrofolate HMPREF1015_RS02865 deferrochelatase/ ferroheme b molybdopterin octanoyl transferase: NAD+ synthetase, precorrin-1 peroxidase EfeB: protoheme IX dehydrogenase/ 2-dehydropantoate HMPREF1015_RS14005 2'-deoxyguanosine HMP-PP protoporphyrin IX di-trans,poly-cis-undecaprenyl molybdenumtransferase a [glycine-cleavage HMPREF1015_RS01575 NH3-dependent: farnesyltransferase: methenyltetrahydrofolate an oxidized UDP-α-D- sn-glycero-3- a monocarboxylic 3-[(7'-methylthio) a supercoiled RS13475 uroporphyrinogen-III MoeA: complex H protein] 2'-deoxyadenosine cob(I)yrinate a,c- 5-hydroxytryptophol an apo-[aryl- propanoyl-CoA H O oleoyl-CoA arsenate HMPREF1015_RS07880 phosphate biosynthesis cyclohydrolase FolD: 2-dehydropantoate ammonium H O ferredoxin [iron- coenzyme A 2 HMPREF1015_RS10110 lipoate biosynthesis C-methyltransferase: 6 2 glucuronate phosphoethanolamine acid amide heptyl]malate duplex DNA RS07095 met ferrochelatase: deferrochelatase/ HMPREF1015_RS11000 N -octanoyl-L-lysine ATP diamide-[corrinoid carrier protein] glycerophosphodiester methionine--tRNA ligase: ferroheme o and incorporation I HMPREF1015_RS13900 2-reductase: sulfur] cluster UDP- acyl-CoA thioesterase: acyl-CoA dehydrogenase: 3-isopropylmalate helicase: arsenate reductase HMPREF1015_RS06515 NAD + peroxidase EfeB: (2E,6E)-farnesyl HMPREF1015_RS02865 MoO -molybdopterin GcvH:[lipoyl domain] purine-nucleoside adenosyltranferase] ferredoxin-- holo-ACP synthase: an L-methionyl- IPP 10 HMPREF1015_RS10240 2 ATP:cob(I)alamin glucuronosyltransferase: phosphodiesterase: HMPREF1015_RS07035 amidase: HMPREF1015_RS00365 HMPREF1015_RS01575 diphosphate an N - amidotransferase: nitrite reductase: HMPREF1015_RS09115 HMPREF1015_RS01200 dehydrogenase: HMPREF1015_RS01855 (thioredoxin): [elongator di-trans,poly-cis-decaprenyl cofactor phosphorylase: adenosyltransferase: HMPREF1015_RS08460 HMPREF1015_RS13850 [+ 2 isozymes] HMPREF1015_RS13295 ferroheme b heme A synthase: an octanoyl-[acp] formyltetrahydrofolate precorrin-2 β-alanine HMPREF1015_RS02875 a holo-[aryl- [+ 5 isozymes] HMPREF1015_RS04060 [+ 3 isozymes] HMPREF1015_RS02510 elongator Met ferrochelatase: (R)-pantoate HMPREF1015_RS05020 HMPREF1015_RS12380 HMPREF1015_RS06820adenosyl- 5-hydroxytryptophol sn-glycerol RS01750 tRNA ] thiamine diphosphate HMPREF1015_RS10105 diphosphate:isopentenyl- UDP 3',5'-ADP ethanolamine propanoate Met purine-nucleoside a [corrinoid nitrite glucuronide carrier protein] (2E,9Z)- 10-(methylthio)- a single RS06805 tRNA biosynthesis III (Staphylococcus) HMPREF1015_RS06515 diphosphate octanoyl transferase: a [lipoyl-carrier protein] triphosphate cobyrinate 3-phosphate a monocarboxylate arsenite 6 phosphorylase: adenosyltransferase] octadecenoyl-CoA 2-oxodecanoate stranded DNA 2-(2-carboxy-4- ferroheme i undecaprenylcistransferase: HMPREF1015_RS14005 pantoate--beta- N -octanoyl-L-lysine a,c-diamide thioredoxin pathway ferroheme b a [lipoyl-carrier protein] HMPREF1015_RS12380 2'-deoxyinosine HMP-PP methylthiazol-5- di-trans,octa-cisHMPREF1015_RS10875 N 6 -octanoyl-L-lysine alanine ligase: lipoyl synthase: sirohydrochlorin bis(guanylyl molybdenum yl)ethylthiamine phosphate phosphate heme A synthase: -undecaprenyl HMPREF1015_RS13110 HMPREF1015_RS00985 purine-nucleoside a plant soluble N-acetyl-D- RS04185 lipoyl synthase: phosphatidylglycerophosphate (+)-7-epi- 3-amino-4- 3-[(6'-methylthio) RS13545 Lys cofactor) biosynthesis an oxidized synthase: HMPREF1015_RS10105 diphosphate phosphorylase: a 5-L-glutamyl- [EntB aryl- H O meso-tartrate DMKH a tRNA a [lipoyl-carrier an amino acid heteroglycan coenzyme A galactosamine jasmonoyl-CoA 2 hydroxybenzaldehyde L-saccharopine hexyl]malate 2 lysine--tRNA ligase: HMPREF1015_RS00985 6 (1-octadecenoyl(9Z), 2-palmitoyl) carrier protein] MoO - thioredoxin HMPREF1015_RS12500 undecaprenyl- protein]-N -[(R)- 2-deoxy-α-D- HMPREF1015_RS12380 [peptide] glycogen/starch/alpha- 6-phosphate acyl-CoA thioesterase: HMPREF1015_RS00150 2 thiamine hydroxyferroheme i a [lipoyl-carrier (R)-pantothenate gamma-glutamyltransferase: holo-ACP synthase: N-acetylglucosamine-6- arylamine N- saccharopine 3-isopropylmalate demethylmenaquinone an L-lysyl- molybdopterin diphosphatase: folate polyglutamylation dihydrolipoyl]-L-lysine ribose 1-phosphate phosphatidylglycerophosphatase glucan phosphorylase: HMPREF1015_RS11040 tartrate dehydrogenase: Lys phosphate protein]-N 6 -[(R)- HMPREF1015_RS01325 HMPREF1015_RS09115 phosphate deacetylase: acetyltransferase: dehydrogenase: dehydrogenase: methyltransferase: [tRNA ] cofactor HMPREF1015_RS05675 A: HMPREF1015_RS00950 an α-(5-L- HMPREF1015_RS02030 [+ 2 isozymes] HMPREF1015_RS01770 bis(molybdenum dihydrolipoyl]-L-lysine siroheme phosphopentomutase: α a holo-[EntB aryl- HMPREF1015_RS05680 HMPREF1015_RS04125 HMPREF1015_RS01235 HMPREF1015_RS04060 HMPREF1015_RS13245 RS13590 RS13845 lys thioredoxin- thiamine diphosphate a peptide glutamyl)- -D-glucopyranose a plant soluble 3',5'-ADP D-galactosamine (+)-7-epi- cofactor) synthase: undecaprenyl- base-degraded thiamine salvage a tetrahydrofolate HMPREF1015_RS13625 1-oleoyl-2-palmitoyl- 3-acetylamino-4- glu 9-(methylthio)- 2-hydroxy-3- disulfide reductase: biosynthesis I (E. coli) guanosine nucleotides 1-phosphate heteroglycan carrier protein] acetate 6-phosphate jasmonate allysine MQH HMPREF1015_RS09685 diphosphate phosphatase: amino acid 2 bis(molybdenum HMPREF1015_RS05590 guanylyl molybdenum (R)-4'- 2-deoxy-D-ribose degradation III phosphatidylglycerol hydroxybenzaldehyde 2-oxononanoate oxosuccinate HMPREF1015_RS12595 formylaminopyrimidine cofactor) thiamine ferroheme a HMP-PP cofactor biosynthesis phosphopantothenate serine formate-- bifunctional 5-phosphate thiamine phosphate di-trans,octa-cis- formylaminopyrimidine RS07260 molybdenum cofactor MoO - glutathione biosynthesis hydroxymethyltransferase: tetrahydrofolate ligase: folylpolyglutamate synthase/ RS07370 his synthase: 2 undecaprenyl phosphate deformylase: deoxyribose- GMP UDP-N-acetyl-α-D-muramoyl- dihomo γ- (2R)-phospho- 3-[(5'-methylthio) D-ribulose guanylyltransferase: a reduced thiamine diphosphokinase: molybdopterin HMPREF1015_RS04730 HMPREF1015_RS12905 dihydrofolate synthase: D-alanyl-D-alanine F6P maltohexaose [EntF L-seryl- AsbD acyl- H O N-acetyl- DHAP histidine--tRNA ligase: HMPREF1015_RS08520 NAD phosphorylation and dephosphorylation L-alanyl-γ-D-glutamyl-L-lysine coenzyme A coenzyme A linolenoyl-CoA 2 3-sulfolactate pentyl]malate HMPREF1015_RS09685 HMPREF1015_RS10515 HMPREF1015_RS12500 HMPREF1015_RS14965 phosphate aldolase: bifunctional carrier protein] carrier protein L-citrulline 5-phosphate HMPREF1015_RS14710 an L-histidyl- thioredoxin thiamine cofactor molybdopterin- cys glu aminomethylpyrimidine UDP-N-acetylmuramoyl- fructose-6- glycogen/starch/alpha- acyl-CoA thioesterase: bis(guanylyl 10 HMPREF1015_RS02280 metallophosphatase/ holo-ACP synthase: holo-ACP synthase: acetylornithine 2-phosphosulfolactate 3-isopropylmalate ribulose-phosphate His a 5,10- an N - phosphate aldolase: glucan phosphorylase: HMPREF1015_RS11040 methylglyoxal synthase: [tRNA ] thiamine phosphate guanine dinucleotide + tripeptide--D-alanyl- deacetylase: phosphatase: dehydrogenase: 3-epimerase: His molybdopterin thiaminase II: NAD methylenetetrahydrofolate formyltetrahydrofolate 5'-nucleotidase: HMPREF1015_RS09115 HMPREF1015_RS09115 RS03625 a tRNA demethylmenaquinol- diphosphate biosynthesis protein B: γ a tetrahydrofolate D- alanine ligase: HMPREF1015_RS04830 HMPREF1015_RS02030 a holo-[EntF [+ 2 isozymes] HMPREF1015_RS13135 RS04635 cofactor) -L-glutamyl- HMPREF1015_RS08525 D-glyceraldehyde HMPREF1015_RS01000 D-glyceraldehyde α a holo-[AsbD acyl- di-homo-γ- HMPREF1015_RS08520 HMPREF1015_RS11050 HMPREF1015_RS04060 HMPREF1015_RS10510 bifunctional bifunctional acetaldehyde -D-glucopyranose 3',5'-ADP L-seryl-carrier 3',5'-ADP 8 biosynthesis I HMPREF1015_RS11005 L-cysteine 3-phosphate HMPREF1015_RS09130 dihydroxyacetone maltopentaose carrier protein] acetate L-citrulline 8-(methylthio)- D-xylulose 4-amino-2-methyl-5- folylpolyglutamate synthase/ folylpolyglutamate synthase/ [+ 2 isozymes] UDP-N-acetyl-α-D-muramoyl-L-alanyl- 3-phosphate 1-phosphate linolenate (2R)-3-sulfolactate methylglyoxal molybdenum cofactor protein] 2-oxooctanoate 5-phosphate 2-carboxy-1,4- menaquinol-9 biosynthesis glutathione synthetase: alkaline phosphatase: NAD kinase: dihydrofolate synthase: dihydrofolate synthase: acetaldehyde guanosine γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine thiamine guanylyltransferase: pyrimidinemethanol RS03210 naphthoquinol HMPREF1015_RS04000 HMPREF1015_RS04560 HMPREF1015_RS06080 HMPREF1015_RS14965 HMPREF1015_RS14965 dehydrogenase glycine--tRNA ligase: 1,4-dihydroxy-2-naphthoate diphosphate guanylylHMPREF1015_RS09685 purine-nucleoside RS03630 10 (acetylating): gly octaprenyltransferase: demethylmenaquinol-9 molybdenum a 5,10- an N - UDP-α-D- a long-chain 3-[(4'-methylthio) D-ribose 5- HMPREF1015_RS14330 glutathione HMPREF1015_RS04145 phosphorylase: a lipid II tetraiodothyroacetate a maltodextrin H O uroporphyrinogen-I pyridoxal 3-ethylmalate demethylmenaquinone methylenetetrahydrofolate formyltetrahydrofolate VibB coenzyme A a type IV prepilin 2 HMPREF1015_RS14335 HMPREF1015_RS02035 cofactor HMPREF1015_RS12380 glucuronate fatty acyl-CoA butyl]malate phosphate Gly demethylmenaquinol-8 methyltransferase: + D-Ala-D-Ala UDP- glycogen/starch/alpha- acyl-CoA thioesterase: a glycyl-[tRNA ] NADP acetyl-CoA holo-ACP synthase: prepilin peptidase: uroporphyrinogen 3-oxoacyl-[acyl-carrier- 3-isopropylmalate 3-isopropylmalate ribose 5-phosphate RS02185 HMPREF1015_RS13245 carboxypeptidase VanY: glucuronosyltransferase: glucan phosphorylase: HMPREF1015_RS07035 Gly decarboxylase: protein] reductase: dehydrogenase: dehydrogenase: isomerase B: a tRNA guanine HMPREF1015_RS12385 HMPREF1015_RS08460 HMPREF1015_RS02030 HMPREF1015_RS09115 HMPREF1015_RS08935 RS07480 menaquinol-9 [+ 2 isozymes] HMPREF1015_RS06520 HMPREF1015_RS10560 HMPREF1015_RS04060 HMPREF1015_RS04060 HMPREF1015_RS04745 superpathway of pyrimidine a N-acetylglucosamine--N- tetraiodothyroacetate α-D-glucopyranose a holo-[VibB aryl- a cleaved type a long-chain UDP a maltodextrin 3',5'-ADP a peptide 7-(methylthio)-2- D-ribulose ribonucleosides degradation D-ala acetylmuramyl-(tetrapeptide) ester glucuronide 1-phosphate carrier protein] IV prepilin fatty acid coproporphyrinogen I 4-pyridoxolactone 2-oxovalerate pyrophosphoryl-undecaprenol oxoheptanoate 5-phosphate RS06385 cytidine met cytidine deaminase: RS07510 methionine--tRNA ligase: xanthine 10 UDP-α-D- UDP-α-D- (3E,5Z)-tetradeca- an (S)-2- 3-[(3'-methylthio) UDP HMPREF1015_RS02285 an N - an L-methionyl- tetraiodothyroacetate 3,3',5- palmitoyl-CoA H O porphobilinogen (indol-3-yl) L-tartrate HMPREF1015_RS00365 2 an L-methionyl- uridine formyltetrahydrofolate [initiator tRNA Met ] glucuronate glucuronate triiodothyroacetate 3,5-dienoyl-CoA halocarboxylate acetamide propyl]malate ribonucleotide- Met xanthine dehydrogenase UDP- UDP- acyl-CoA thioesterase: HAD family hydrolase: acyl-CoA thioesterase: RS14370 [initiator tRNA ] pyrimidine-nucleoside methionyl-tRNA hydroxymethylbilane 3-isopropylmalate diphosphate reductase: initiator tRNA Met subunit D: glucuronosyltransferase: glucuronosyltransferase: HMPREF1015_RS11040 HMPREF1015_RS08660 HMPREF1015_RS07035 amidase: tartrate dehydrogenase: phosphorylase: deoA formyltransferase: synthase: dehydrogenase: HMPREF1015_RS08125 HMPREF1015_RS16050 HMPREF1015_RS08460 HMPREF1015_RS08460 [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] HMPREF1015_RS13295 HMPREF1015_RS01770 RS03245 an N-formyl- HMPREF1015_RS10480 HMPREF1015_RS15015 HMPREF1015_RS04060 HMPREF1015_RS08130 uracil tetraiodothyroacetate triiodothyroacetate (3E,5Z)- an (R)-2- xanthine dehydrogenase: a tetrahydrofolate UDP UDP coenzyme A a halide anion palmitate 6-(methylthio)- 2-hydroxy-3- L-methionyl- ether glucuronide ester glucuronide tetradecadienoate hydroxyacid preuroporphyrinogen (indol-3-yl)acetate dUDP RS14640 HMPREF1015_RS16055 [initiator tRNA met ] 2-oxohexanoate oxosuccinate urate RS07560 UDP-α-D- UDP-α-D- dCDP 5,6-dihydrouracil a ring-opened 7- a glycogen 3,3',5- (S)-4-amino-5- (indole-3-yl) a negatively a tRNA glu (S)-nicotine HMG-CoA D-threo-isocitrate MeOH methylguanine in DNA glucuronate triiodothyroacetate oxopentanoate glucuronate acetonitrile supercoiled DNA ribonucleotide- RS07475 hydantoinase/oxoprolinase DNA-formamidopyrimidine glycogen/starch/alpha- UDP- UDP- hydroxymethylglutaryl- glutamyl-tRNA reductase: NADP-dependent diphosphate reductase: family protein: glycosylase: glucan phosphorylase: glucuronosyltransferase: glucuronosyltransferase: CoA lyase: nitrilase: DNA topoisomerase III: catalase: HMPREF1015_RS15025 isocitrate dehydrogenase: HMPREF1015_RS08125 HMPREF1015_RS04400 HMPREF1015_RS15310 HMPREF1015_RS02030 HMPREF1015_RS08460 HMPREF1015_RS08460 HMPREF1015_RS01180 HMPREF1015_RS07470 HMPREF1015_RS07005 HMPREF1015_RS12615 RS05760 2,6-diamino-4- an L-glutamyl- HMPREF1015_RS15330 HMPREF1015_RS08130 an apurinic site α-D-glucopyranose triiodothyroacetate nicotine- hydroxy-5-(N-methyl) an α-limit dextrin UDP [tRNA Glu ] UDP acetyl-CoA acetoacetate RS13550 3-ureidopropanoate within DNA 1-phosphate ether glucuronide glucuronide 2-oxoglutarate (indol-3-yl)acetate a relaxed DNA formaldehyde CDP formamidopyrimidine

RS07640 a single a linear malto- UDP-α-D- (S)-4-hydroxy- a (2E,4E)- a double uridine a glycogen 2-succinylbenzoate coenzyme A cotinine reduced riboflavin ethanol RS04900 stranded DNA oligosaccharide glucuronate 2-oxopentanoate dienoyl-CoA stranded DNA β-alanine purine ribonucleosides degradation exodeoxyribonuclease VII: glycogen/starch/alpha- glycogen/starch/alpha- o-succinylbenzoate- UDP- 4-hydroxy-2- uridine kinase: HMPREF1015_RS13890 glucan phosphorylase: glucan phosphorylase: -CoA ligase: glucuronosyltransferase: oxovalerate aldolase: FMN reductase (NADPH) 2,4-dienoyl-CoA reductase: DNA gyrase subunit A: catalase: HMPREF1015_RS14585 HMPREF1015_RS13895 HMPREF1015_RS02030 HMPREF1015_RS02030 HMPREF1015_RS02060 HMPREF1015_RS08460 HMPREF1015_RS04140 : HMPREF1015_RS07030 HMPREF1015_RS15645 HMPREF1015_RS05040 HMPREF1015_RS12615 RS00220 a single-stranded a ribonucleoside α-D-glucopyranose a linear malto- α-D-glucopyranose 4-(2'-carboxyphenyl) cotinine- UMP RS06575 adenosine maltotetraose UDP pyruvate acetaldehyde a (2E)-2- a negatively oligodeoxyribonucleotide 5'-monophosphate 1-phosphate oligosaccharide 1-phosphate -4-oxobutyryl-CoA glucuronide riboflavin acetaldehyde enoyl-CoA supercoiled DNA

RS12655 a [glycine-cleavage ω a (2E,4Z)- RS03250 a [dinitrogen reductase]-N - maltopentaose methyl red a tripeptide nicotinate PRPP uroporphyrinogen-III butan-2-one propionamide SAM complex H protein] a sulfurated [sulfur carrier] α-( ADP-D-ribosyl)-L-arginine dienoyl-CoA 6 ADP-ribosyl-[dinitrogen glycogen/starch/alpha- FMN-dependent peptidase T: nicotinate xanthosine adenosine inosine guanosine N -octanoyl-L-lysine lipoyl synthase: uroporphyrinogen-III acetone carboxylase: glucan phosphorylase: phosphoribosyltransferase: 2,4-dienoyl-CoA reductase: amidase: reductase] hydrolase: NADH-azoreductase: HMPREF1015_RS12140 C-methyltransferase: HMPREF1015_RS04390 HMPREF1015_RS00985 HMPREF1015_RS02030 HMPREF1015_RS15645 HMPREF1015_RS13295 RS02090 a [glycine-cleavage HMPREF1015_RS09575 HMPREF1015_RS08495 a proteinogenic HMPREF1015_RS07875 HMPREF1015_RS02865 RS11220 an unsulfurated a [dinitrogen α-D-glucopyranose a dipeptide HMPREF1015_RS04395 5'-deoxyadenosine met complex H protein] ADP-D-ribose N,N-dimethyl-1,4- anthranilate amino acid NaMN purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside [sulfur carrier] maltotetraose a (3E)-3- N 6 -lipoyl-L-lysine reductase]-L-arginine 1-phosphate phenylenediamine precorrin-2 3-oxopentanoate propanoate phosphorylase: phosphorylase: phosphorylase: phosphorylase: enoyl-CoA HMPREF1015_RS12380 HMPREF1015_RS12380 HMPREF1015_RS12380 HMPREF1015_RS12380 RS05330 RS08820 a dipetide with an N- 2-hydroxy-2- a (2E,4E)- α-D-ribose- a sulfurated maltoheptaose maltotetraose a colanic acid lipid A-core D-glycerate a nitrile SAM dethiobiotin glutathione hypoglycin A terminal L-aspartate methylpropanenitrile dienoyl-CoA 1-phosphate [sulfur carrier] glycogen/starch/alpha- glycogen/starch/alpha- O-antigen ligase domain- dipeptidase PepV: biotin synthase BioB: gamma-glutamyltransferase: D-glycerate phosphopentomutase: glucan phosphorylase: glucan phosphorylase: containing protein: HMPREF1015_RS15730 nitrilase: 2,4-dienoyl-CoA reductase: nitrilase: HMPREF1015_RS10975 HMPREF1015_RS01325 dehydrogenase: RS01290 HMPREF1015_RS13625 HMPREF1015_RS02030 HMPREF1015_RS02030 HMPREF1015_RS05420 a proteinogenic HMPREF1015_RS07470 HMPREF1015_RS15645 HMPREF1015_RS07470 RS08860 an unsulfurated asp HMPREF1015_RS02755 met 5'-deoxyadenosine biotin L-cysteinylglycine hypoglycin B α-D-glucopyranose α-D-glucopyranose E. coli M D-ribose 5- maltohexaose maltotriose LPS amino acid 2-hydroxy-2- a (3E)-3- [sulfur carrier] 1-phosphate 1-phosphate hydroxypyruvate a carboxylate phosphate methylpropanoate enoyl-CoA

RS04220 UTP and CTP dephosphorylation I RS09750 5,10-methylene- 3-methyl-2- a 7,8-dihydro-8- amino-parathion ammonium NAD(P) + H O O-ureido-L- leukotriene-D4 stearoyl-CoA H O D-glycerate methylglyoxal UTP 2 asp 2 GGPP IPP tetrahydromethanopterin oxobutanoate oxoguanine in DNA homoserine 3-methyl-2-oxobutanoate phosphotriesterase: DNA-formamidopyrimidine nitrite reductase membrane dipeptidase: acyl-CoA thioesterase: heptaprenyl diphosphate D-glycerate argininosuccinate synthase: glyoxalase: formate formate RS08810 CTP synthase: hydroxymethyltransferase: HMPREF1015_RS05950 glycosylase: (NAD(P)H) small subunit: HMPREF1015_RS00690 HMPREF1015_RS07035 synthase component II: dehydrogenase: RS03725 HMPREF1015_RS15445 HMPREF1015_RS08690 nitrite nitrite HMPREF1015_RS04850 HMPREF1015_RS13115 HMPREF1015_RS15310 HMPREF1015_RS14105 [+ 2 isozymes] HMPREF1015_RS13240 HMPREF1015_RS02755 4-aminophenol diethylthiophosphate an apurinic site 7,8-dihydro- canavaninosuccinate leukotriene-E4 gly all-trans- UMP THMPT 2-dehydropantoate nitrite stearate heptaprenyl formate formate CTP within DNA 8-oxoguanine hydroxypyruvate (R)-lactate RS02430 diphosphate nitrite nitrite RS16475 bifunctional metallophosphatase/ 5'-nucleotidase: glucosyl-(heptosyl) - UDP-α-D- (Z,Z)- UDP-α-D- D-firefly a debranched galactitol 1- phosphoenol UDP-α-D-glucuronate 3 methyl parathion oleanolate FMN NAD(P)H H + H O RS08925 CMP HMPREF1015_RS01000 Kdo -lipid A-phosphate sarcosine 2 α-limit dextrin 2 glucuronate bilirubin-IX α glucuronate luciferyl-CoA phosphate pyruvate UDP- phosphotriesterase: UDP- UDP- FMN reductase (NADPH) acyl-CoA thioesterase: glycogen/starch/alpha- RS15860 bifunctional [+ 2 isozymes] glycine oxidase ThiO: galactitol-1-phosphate glucuronosyltransferase: HMPREF1015_RS05950 glucuronosyltransferase: glucuronosyltransferase: : HMPREF1015_RS07030 HMPREF1015_RS11040 glucan phosphorylase: pyruvate kinase: metallophosphatase/ uridine HMPREF1015_RS07190 5-dehydrogenase: HMPREF1015_RS08460 HMPREF1015_RS08460 HMPREF1015_RS08460 + [+ 2 isozymes] HMPREF1015_RS15350 5'-nucleotidase: dimethylthiophosphate 4-nitrophenol NAD(P) FMNH HMPREF1015_RS02030 HMPREF1015_RS07595 glucosyl-(heptosyl) -glucosyluronate- C8-β-glucuronosyl- oleanolate 3 β- 2 methylamine glyoxylate 3 UDP UDP UDP D-firefly luciferin α-D-glucopyranose keto-D-tagatose RS10765 thymine degradation HMPREF1015_RS01000 Kdo -lipid A-phosphate bilirubin-IX α D-glucuronoside 2 1-phosphate pyruvate RS13925 [+ 2 isozymes] 6-phosphate thymine cytidine 3-benzyl-3,6 -bis(cysteinylglycine)- RNase R degradation UDP-α-D- glutathione glycyl-glycine L-thyroxine a uracil in DNA an aryl dialkyl an acyl-CoA H O lauroyl-CoA H O 2-deoxy-D-ribose pyrazinamide RS05115 5,6-dihydrothymine 6-(hydroxymethyl)-diketopiperazine substrate RNA glucuronate phosphate 2 2 RS04120 membrane dipeptidase: gamma-glutamyltransferase: ribonuclease R: UDP- uracil-DNA glycosylase: acyl-CoA thioesterase: acyl-CoA thioesterase: hydantoinase/oxoprolinase phosphotriesterase: ribokinase: HMPREF1015_RS00690 HMPREF1015_RS01325 HMPREF1015_RS05470 glucuronosyltransferase: HMPREF1015_RS09665 HMPREF1015_RS11040 HMPREF1015_RS07035 amidase: family protein: S-methyl-5'-thioadenosine HMPREF1015_RS05950 HMPREF1015_RS05005 γ-L-glutamyl- a nucleoside 5'- HMPREF1015_RS08460 an apyrimidinic a dialkyl [+ 2 isozymes] [+ 2 isozymes] HMPREF1015_RS13295 degradation IV gly 3-benzyl-3,6 -bis(cysteinyl)- 6- L-cysteinylglycine a diribonucleotide uracil HMPREF1015_RS04400 glycylglycine monophosphate L-thyroxine acyl a phenol (hydroxymethyl)-diketopiperazine UDP site in DNA phosphate a carboxylate laurate 2-deoxy-D-ribose pyrazine-2- RS13935 RS08985 β-D-glucuronide 3-(carbamoylamino)- S-methyl-5'- 5-phosphate carboxylate 2-methylpropanoate thioadenosine5'-methylthioadenosine/ S-adenosylhomocysteine a DNA containing a generic 7,8- nucleosidase: an apurinic/ [DNA] FMNH NADP + FMNH NAD + L-canavanine oleoyl-CoA H O D-glucopyranose (S)-malate RS10770 RS13525 HMPREF1015_RS14570 polynucleotide substrate dihydromonapterin 2 2 2 thermonuclease: dihydroneopterin aldolase: apyrimidinic site exodeoxyribonuclease III: FMN reductase (NADPH) FMN reductase (NADPH) arginase: acyl-CoA thioesterase: (R)-3-amino-2- MTR endonuclease III: xylose isomerase: malate:quinone HMPREF1015_RS02980 HMPREF1015_RS00170 HMPREF1015_RS02450 : HMPREF1015_RS07030 : HMPREF1015_RS07030 HMPREF1015_RS01640 HMPREF1015_RS07035 methylpropanoate HMPREF1015_RS13075 a 2'- HMPREF1015_RS15990 oxidoreductase: a nucleoside 3'- a 3' phosphooligonucleotide 6-(hydroxymethyl) + + [+ 2 isozymes] glycolaldehyde a 3'-terminal a 5'-phospho- deoxyribonucleoside [DNA] H NADPH FMN H NADH FMN urea L-canaline HMPREF1015_RS05810 RS01330 monophosphate RNA -7,8-dihydropterin unsaturated sugar [DNA] oleate RS02260 5'-monophosphate keto-D-fructose oxaloacetate Detoxification

RS00460 reactive oxygen species degradation a proteinogenic a 5S rRNA a single a ribonucleoside + (2R,3S)-2- L-iditol β-D-galactose glutathione a ribonucleic acid hydrogencarbonate H canavaninosuccinate a tRNA sec ser RS02750 oxidized GTP and dGTP detoxification amino acid precursor stranded DNA triphosphate methylisocitrate ribonuclease M5: DNA primase: ribonuclease PH: carbonic anhydrase: argininosuccinate lyase: methylisocitrate lyase: superoxide gamma-glutamyltransferase: serine--tRNA ligase: sorbitol dehydrogenase: aldose 1-epimerase: HMPREF1015_RS00350 HMPREF1015_RS15085 HMPREF1015_RS06960 HMPREF1015_RS15440 HMPREF1015_RS07440 HMPREF1015_RS01325 HMPREF1015_RS14310 HMPREF1015_RS00050 HMPREF1015_RS07605 HMPREF1015_RS16000 dGTP GTP an α-(γ-L-glutamyl) a double-stranded a mature 5S-rRNA ssDNA/pppN(pN) a nucleoside H O CO fumarate L-canavanine pyruvate succinate an L-seryl- F0F1 ATP RS04955 superoxide dismutase: L-cysteinylglycine a ribonucleic acid 2 2 + + -L-amino acid oligonucleotide hybrid diphosphate sec H H HMPREF1015_RS07245 n -1 [tRNA ] keto-L-sorbose α-D-galactose synthase superoxide dismutase: HMPREF1015_RS14220 8-oxo-dGTP 8-oxo-GTP H + RS10725 H + RS11255 D-sedoheptulose D-glyceraldehyde 7,8-dihydrofolate D-erythrose D-xylulose (S)-2,3- 2'-deoxycytidine hydrogen 8-oxo-dGTP a proteinogenic NADPH H + N-ethylglycine H O acetyl-CoA carbonic acid leukotriene-C4 7-phosphate 3-phosphate asp fumarate 4-phosphate 5-phosphate 2 peroxide amino acid monoglutamate dihydrodipicolinate H + RS02520 H + diphosphatase: glycine oxidase ThiO: acetyl-CoA hydrolase: deoxynucleoside kinase: gamma-glutamyltransferase: transketolase: dihydrofolate reductase: L-aspartate oxidase: transketolase: dipicolinate carbonic anhydrase: HMPREF1015_RS05585 HMPREF1015_RS03085 HMPREF1015_RS12275 HMPREF1015_RS03085 HMPREF1015_RS07190 HMPREF1015_RS12235 synthase subunit B: HMPREF1015_RS05275 HMPREF1015_RS06960 catalase: HMPREF1015_RS01325 D-xylulose D-ribose 5- HMPREF1015_RS14855 D-glyceraldehyde a reduced 8-oxo-GMP α γ + tetrahydropteroyl RS01015 HMPREF1015_RS12615 an -( -L-glutamyl) NADP F6P ethylamine glyoxylate acetate HMPREF1015_RS00805 CO H O 8-oxo-dGMP leukotriene-D4 5-phosphate phosphate mono-L-glutamate succinate 2-iminosuccinate 3-phosphate dCMP 2 2 H O c-type -L-amino acid dipicolinate 2 RS16205 cytochrome H O hydroxyl radical an oxidized O 2 O c-typea reduced 2 2 a branched- H O cytochromec-type 2 cytochrome chain cytochrome an amino an amino an amino c oxidase an oxidized RS14090 amino acid D-sorbitol a dicarboxylate galactitol 1- O c-type molybdate acid acid acid 2 a purine 2-dehydro- a branched- a branched- 6-phosphate phosphate cytochrome G a basic an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino a sugar 6- nucleoside glutamate D-trehalose sucrose 6 an aliphatic 3-deoxy-D- D-fructose D-fructose chain chain D-glucose 6- D-glucose 6- D-glucose 6- a C4- L-ascorbate a pyrimidine (S)-lactate ferrichrome amino acid chromate chromate chromate an aromatic a macrolide acid acid acid acid acid acid acid acid acid acid acid acid acid acid a nucleotide phosphate 6-phosphate -phosphate sulfonate gluconate 1-phosphate 1-phosphate amino acid amino acid phosphate phosphate phosphate dicarboxylate uracil 6-phosphate nucleoside predicted carboxylate ABC predicted predicted predicted predicted predicted predicted transporter ABC ABC ABC ABC PEP-driven PEP-driven RS10440 RS12720 RS05970 RS12545 RS08980 RS03480 RS12305 RS13320 RS01610 RS13495 RS03675 RS02895 RS10040 RS03050 RS05755 RS07525 RS02730 RS14390 RS04215 RS01250 RS07375 RS07325 RS11845 RS05730 RS14615 RS12160 RS07620 RS08730 RS05270 RS14685 RS08645 RS09510 RS08195 RS01315 RS03460 RS12095 RS07010 RS01475 RS00850 RS02255 of a RS15765 RS01345 RS15760 RS07900 RS12340 RS03235 RS13800 RS07220 RS09330 RS01255 RS11280 RS02275 RS06545 RS07085 RS07175 RS00825 RS17470 RS03720 RS06005 RS16155 RS01735 RS04350 RS02345 RS07105 RS02240 RS07155 RS02725 transporter transporter RS01765 RS04435 transporter RS05835 RS02350 RS08370 RS14975 RS11685 RS12285 RS14445 RS12670 RS08420 RS06015 RS02295 RS08435 RS11500 RS12230 RS04425 RS10785 RS03100 RS02695 RS06035 RS13180 RS04355 RS03310 RS14930 transporter transporter transporter branched- of an of an of an of molybdate of D-sorbitol of galactitol chain amino acid amino acid amino acid amino acid

2-dehydro- a branched- a branched- a branched- a pyrimidine a sugar trehalose sucrose an aliphatic D-fructose D-fructose D-glucose D-glucose D-glucose a C4- uracil D-sorbitol an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino galactitol a purine (S)-lactate ferrichrome a basic chromate chromate chromate molybdate L-ascorbate a macrolide nucleoside an amino an amino an amino an amino an amino an amino a nucleotide glutamate sulfonate 3-deoxy-D- chain chain chain an aromatic dicarboxylate a dicarboxylatean amino nucleoside amino acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid gluconate amino acid amino acid amino acid carboxylate acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.