Publications for Mary Collins

2021 Anderson, L., Absalom, N., Abelev, S., Low, I., Doohan, P., Luo, Y., Kusay, A., Jiang, T., Collins, M., Balle, T. (2021). Martin, L., Chebib, M., McGregor, I., Arnold, J. (2019). Delta-containing GABAA receptors in pain management: Coadministered cannabidiol and clobazam: Preclinical evidence Promising targets for novel analgesics. Neuropharmacology, for both pharmacodynamic and pharmacokinetic interactions. 195, 108675. [M href="http://dx.doi.org/10.1111/epi.16355">[More ore Information] Information] Liao, V., Collins, M., Ahring, J. (2021). Efficient expression of Liao, V., Chua, H., Kowal, N., Collins, M., Balle, T., Ahring, J. concatenated ?1?2? and ?1?3? GABAA receptors, their (2019). Concatenated y-aminobutyric acid type A receptors pharmacology and stoichiometry. British Journal of revisited: Finding order in chaos. Journal of General Pharmacology, 178(7), 1556-1573. [More href="http://dx.doi.org/10.1085/jgp.201812133">[More Information] Information] van Nieuwenhuijzen, P., Parker, K., Liao, V., Houlton, J., Kim, Absalom, N., Ahring, J., Liao, V., Balle, T., Jiang, T., H., Johnston, G., Hanrahan, J., Collins, M., Clarkson, A. Anderson, L., Arnold, J., McGregor, I., Bowen, M., Chebib, M. (2021). Targeting GABAC Receptors Improves Post-Stroke (2019). Functional genomics of epilepsy-associated mutations Motor Recovery. Brain Sciences, 11(3), 315( 1-19). [More impairs function and two are catastrophic. Journal of Biological Information] Chemistry, 294(15), 6157-6171. [More Devenish, S., Winters, B., Anderson, L., Arnold, J., McGregor, Information] I., Vaughan, C., Collins, M., Absalom, N. (2021). The anticonvulsant zonisamide positively modulates recombinant Solomon, V., Tallapragada, V., Chebib, M., Johnston, G., and native glycine receptors at clinically relevant Hanrahan, J. (2019). GABA allosteric modulators: An overview concentrations. Neuropharmacology, 182, 108371. [M European Journal of Medicinal Chemistry, 171, 434-461. href="http://dx.doi.org/10.1016/j.ejmech.2019.03.043">[More Information] 2020 Kowal, N., Indurthi, D., Ahring, J., Chebib, M., Olafsdottir, E., Qudah, T., Quek, G., Indurthi Venkata, D., Karim, N., Halliday, Balle, T. (2019). Novel Approach for the Search for Chemical J., Absalom, N., McLeod, M., Collins, M. (2020). AE Scaffolds with Dual Activity with Acetylcholinesterase and the Succinimide, an Analogue of Methyllycaconitine, When Bound alpha-7 Nicotinic Acetylcholine Receptor-A Perspective for the Generates a Nonconducting Conformation of the α4β2 Treatment of Neurodegenerative Disorders. Molecules, 24(3), 1- Nicotinic Acetylcholine Receptor. ACS Chemical Neuroscience, 17. [More href="http://dx.doi.org/10.1021/acschemneuro.9b00525">[More Information] Information] Devenish, S., Johnston, G., Chebib, M., Hanrahan, J. (2019). Absalom, N., Liao, V., Kothur, K., Indurthi Venkata, D., Optimising the transient expression of GABA(A) receptors in Bennetts, B., Troedson, C., Mohammad, S., Gupta, S., adherent HEK293 cells. Protein Expression and Purification, McGregor, I., Bowen, M., Ahring, J., Collins, M., et al (2020). 154, 7-15. [More hypersensitive epileptic encephalopathies. Brain Information] Communications, 2(2), fcaa162. [More Balle, T., Collins, M., Absalom, N. (2019). Revisiting Information] autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) Absalom, N., Liao, V., Chebib, M. (2020). Ligand-gated ion mutations in the nicotinic acetylcholine receptor reveal an channels in genetic disorders and the question of efficacy. increase in efficacy regardless of stochiometry. International Journal of Biochemistry and Cell Biology, 126, Pharmacological Research, 139, 215-227. [More href="http://dx.doi.org/10.1016/j.biocel.2020.105806">[More Information] Information] Clarkson, A., Boothman-Burrell, L., Dosa, Z., Nagaraja, R., Jin, Richter, G., Liao, V., Ahring, J., Chebib, M. (2020). The Z- L., Parker, K., van Nieuwenhuijzen, P., Neumann, S., Gowing, Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying E., Gavande, N., Ahring, J., Hanrahan, J., Chebib, M., et al Actions on Human GABA-A Receptors Containing gamma-1, (2019). The flavonoid, 2'-methoxy-6-methylflavone, affords gamma-2, and gamma-3 Subunits. Frontiers in Neuroscience, neuroprotection following focal cerebral ischaemia. Journal of 14, 599812. [More href="http://dx.doi.org/10.1177/0271678X18755628">[More Information] Information] 2019 2018 Che Has, A., Collins, M. (2018). GABAa receptors: Various (2016). GABA-A Receptor Modulation and Anticonvulsant, stoichiometrics of subunit arrangement in alpha1beta3 and Anxiolytic, and Antidepressant Activities of Constituents from alpha1beta3epsilon receptors. Current Pharmaceutical Design, Artemisia indica Linn. Evidence-Based Complementary and 24(17), 1839-1844. [More >[More Information] Information] Kowal, N., Ahring, J., Liao, V., Indurti, D., Harvey, B., Hartiadi, L., Ahring, J., Chebib, M., Absalom, N. (2016). High O'Connor, S., Collins, M., Olafsdottir, E., Balle, T. (2018). and low GABA sensitivity alpha4beta2delta GABAA receptors Galantamine is not a positive allosteric modulator of human are expressed in Xenopus laevis oocytes with divergent alpha-4-beta-2 or alpha-7 nicotinic acetylcholine receptors. stoichiometries. Biochemical Pharmacology, 103, 98-108. [More href="http://dx.doi.org/10.1111/bph.14329">[More Information] Information] Naffa'a, M., Absalom, N., Solomon, V., Collins, M., Hibbs, D., Eldridge, C., Quek, G., Sako, M., Ryan, J., Saubern, S., Chebib, Hanrahan, J. (2016). Investigating the Role of Loop C M., Macdonald, J. (2018). The preparation of novel Hydrophilic Residue 'T244' in the Binding Site of (rho)1 histrionicotoxin analogues and their activity towards the GABAC Receptors via Site Mutation and Partial Agonism. (alpha)4(beta)2 and (alpha)7 nicotinic acetylcholine receptors. PloS One, 11(5), 1-21. [More href="http://dx.doi.org/10.1016/j.tet.2017.11.047">[More Information] Information] Chua, H., Christensen, E., Hoestgaard-Jensen, K., Hartiadi, L., 2017 Ramzan, I., Jensen, A., Absalom, N., Collins, M. (2016). Kavain, the Major Constituent of the Anxiolytic Kava Extract, Naffa'a, M., Hung, S., Chebib, M., Johnston, G., Hanrahan, J. Potentiates GABAA Receptors: Functional Characteristics and (2017). GABA-(rho) receptors: distinctive functions and Molecular Mechanism. PloS One, 11(6), 1-17. [More 174(13), 1881-1894. href="http://dx.doi.org/10.1111/bph.13768">[More Indurthi Venkata, D., Lewis, T., Ahring, J., Balle, T., Collins, Information] M., Absalom, N. (2016). Ligand binding at the (alpha)4- Chua, H., Chebib, M. (2017). GABAA Receptors and the (alpha)4 agonist-binding site of the (alpha)4(beta)2 nAChR Diversity in their Structure and Pharmacology. Advances in triggers receptor activation through a pre-activated Pharmacology, 79, 1-34. [More href="http://dx.doi.org/10.1371/journal.pone.0161154">[More Information] Information] Bakas, T., van Nieuwenhuijzen, P., Devenish, S., McGregor, I., Che Has, A., Absalom, N., van Nieuwenhuijzen, P., Clarkson, Arnold, J., Collins, M. (2017). The direct actions of cannabidiol A., Ahring, J., Collins, M. (2016). Zolpidem is a potent and 2-arachidonoyl stoichiometry-selective modulator of (alpha)1(beta)3 GABAA glycerol at GABA A receptors. Pharmacological Research, receptors: evidence of a novel benzodiazepine site in the 119, 358-370. [More href="http://dx.doi.org/10.1038/srep28674">[More Information] Information] Manan, M., Cordes, D., Slawin, A., Buhl, M., Liao, V., Chua, 2015 H., Collins, M., O'Hagan, D. (2017). The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as Carland, J., Yamamoto, I., Hanrahan, J., Abdel-Halim, H., GABA Agonists. Chemistry - A European Journal, 23(45), Lewis, T., Absalom, N., Chebib, M. (2015). A Hydrophobic 10848-10852. [More Influences Both Receptor Activation and Deactivation. Journal Information] of Molecular Neuroscience, 55(2), 305-313. [More 2016 Information] Ahring, J., Bang, L., Jensen, M., Strobaek, D., Hartiadi, L., Abdelhalim, A., Karim, N., Chebib, M., Aburjai, T., Khan, I., Collins, M., Absalom, N. (2016). A pharmacological Johnston, G., Hanrahan, J. (2015). Antidepressant, Anxiolytic assessment of agonists and modulators at and Antinociceptive Activities of (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) Constituents from Rosmarinus Officinalis. Journal of Pharmacy GABAA receptors: The challenge in comparing apples with and Pharmaceutical Sciences, 18(4), 448-459. [More href="http://dx.doi.org/10.1016/j.phrs.2016.05.014">[More Information] Information] Naffa'a, M., Chebib, M., Hibbs, D., Hanrahan, J. (2015). Lee, H., Absalom, N., Hanrahan, J., van Nieuwenhuijzen, P., Comparison of templates for homology model of rho1 GABAC Ahring, J., Chebib, M. (2016). A pharmacological receptors: More insights to the orthosteric binding site's characterization of GABA, THIP and DS2 at binary structure and functionality. Journal of Molecular Graphics and alpha4Beta3 and Beta3delta receptors: GABA activates Modelling, 62, 43-55. [More Research, 1644, 222-230. href="http://dx.doi.org/10.1016/j.brainres.2016.05.019">[More Ahring, J., Olsen, J., Nielsen, E., Peters, D., Pedersen, M., Information] Rohde, L., Kastrup, J., Shahsavar, A., Indurthi Venkata, D., Khan, I., Karim, N., Ahmad, W., Abdelhalim, A., Collins, M. Chebib, M., Balle, T., et al (2015). Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4- Abdelhalim, A., Chebib, M., Aburjai, T., Johnston, G., alpha4 interface. Neuropharmacology, 92, 135-145. [M Compounds Isolated from Salvia triloba L. Advances in ore Information] Biological Chemistry, 4(2), 148-159. [More Karim, N., Irshad, S., Khan, I., Mohammad, A., Anis, I., Shah, Information] M., Khan, I., Chebib, M. (2015). GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff- Dodonaea viscosa (Linn). Pharmacology, Biochemistry and Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, Behavior, 136, 64-72. [More Subunits Contribute to In Vivo Effects of Ethanol in Mice. PloS Information] One, 9(1), 1-16. [More Neumann, S., Shields, N., Balle, T., Chebib, M., Clarkson, A. Information] (2015). Innate Immunity and Inflammation Post-Stroke: An alpha7-Nicotinic Agonist Perspective. International Journal of Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. Molecular Sciences, 16(12), 29029-29046. [More Methoxyflavanone and 6-Methoxyflavone. Neurochemical Information] Research, 39, 1068-1078. [More Hanrahan, J., Chebib, M., Johnston, G. (2015). Interactions of Information] flavonoids with ionotropic GABA receptors. Advances in Pharmacology, 72, 189-200. [More McIntosh, J., Absalom, N., Chebib, M. (2014). Presence of Information] multiple binding sites on Alpha9Alpha10 nAChR receptors alludes to stoichiometric-dependent action of the Alpha - Bowen, M., Peters, S., Absalom, N., Chebib, M., Neumann, I., conotoxin, Vc1.1. Biochemical Pharmacology, 89(1), 131-140. McGregor, I. (2015). Oxytocin prevents ethanol actions at δ [More subunitcontaining GABAA receptors and attenuates Information] ethanolinduced motor impairment in rats. Proceedings of the National Academy of Sciences of the United States of America, van Nieuwenhuijzen, P., McGregor, I., Chebib, M., Hunt, G. 112(10), 3104-3109. [More hydroxybutyrate (GHB): Comparison with γ-butyrolactone Information] (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Hellyer, S., Indurthi Venkata, D., Balle, T., Runder-Varga, V., Neuroscience, 277, 700-715. [ (2015). Pinnatoxins E, F and G target multiple nicotinic More Information] receptor subtypes. Journal of Neurochemistry, 135(3), 479-491. [More Clarkson, A., Chebib, M. (2014). The Role of Peri-synaptic Information] GABA Receptors After Stroke. In Adam C Errington, Giuseppe Di Giovanni, Vincenzo Crunelli (Eds.), Extrasynaptic Absalom, N., Yamamoto, I., O'Hagan, D., Hunter, L., Collins, GABAA Receptors, (pp. 179-205). New York: Springer M. (2015). Probing the Mode of Neurotransmitter Binding to Science+Business Media. [More Analogues. Australian Journal of Chemistry, 68(1), 23-30. href="http://dx.doi.org/10.1071/CH14456">[More Information] 2013 Chua, H., Absalom, N., Hanrahan, J., Viswas, R., Chebib, M. Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, (2015). The Direct Actions of GABA, 2-Methoxy-6- I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Methylflavone and General Anaesthetics at β3γ2L GABAA Chebib, M. (2013). Covalent trapping of methyllycaconitine at Receptors: Evidence for Receptors with Different Subunit the alpha4-alpha4 interface of the apha4beta2 nicotinic Stoichiometries. PloS One, 10(10), 1-19. [More receptor inhibition revealed. Journal of Biological Chemistry, Information] 288(37), 26521-26532. [More Reactive Analogues of Galanthamine, Codeine, and Morphine Information] as Potential Probes to Interrogate Allosteric Binding within Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Chebib, Nicotinic Acetylcholine Receptors. Australian Journal of M., Hanrahan, J. (2013). Design, synthesis, and Chemistry, 68(12), 1834-1841. [More antagonists of P1 GABA(c) receptors. ACS Medicinal Information] Chemistry Letters, 4(4), 402-407. [More 2014 Information] Beltrán González, A., Pomata, P., Goutman, J., Gasulla, J., Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Chebib, M., Calvo, D. (2014). Benzodiazepine modulation of Hanrahan, J., Chebib, M. (2013). Potency of gaba at human homomeric GABAAp1 receptors: Differential effects of recombinant gaba alpha receptors expressed in xenopus diazepam and 4'-chlorodiazepam. European Journal of oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More href="http://dx.doi.org/10.1016/j.ejphar.2014.09.017">[More Information] Information] Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Chebib, M., href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retri Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) eve&db=pubmed&dopt=Abstract&list_uids=22605922">[More (GABAC) Selective Antagonists Derived from the Bioisosteric Information] Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Amides and Hydroxamates. Journal of Medicinal Chemistry, Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Chebib, M. 56(13), 5626-5630. [More a4b1/b3d GABAA receptor subtypes indicate a different Information] binding mode for GABA at these receptors. Biochemical 2012 Pharmacology, 84(4), 549-557. [More Pan, Y., Gerasimov, M., Kvist, T., Wellendorph, P., Madsen, Information] K., Pera, E., Lee, H., Schousboe, A., Chebib, M., Brauner- Huang, S., Lewis, T., Lummis, S., Thompson, A., Chebib, M., Osborne, H., et al (2012). (1S, 3S)-3-Amino-4- Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent ginkgolides at recombinant human r1 GABAc receptors. gamma-Aminobutyric Acid Aminotransferase Inactivator for Neuropharmacology, 63(6), 1127-1139. [M Chemistry, 55(1), 357-366. href="http://dx.doi.org/10.1021/jm201231w">[More Information] Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Chebib, M. (2012). Absalom, N., Eghorn, L., Villumsen, I., Karim, N., Bay, T., Structurally Diverse GABA Antagonists Interact Differently Olsen, J., Knudsen, G., Brauner-Osborne, H., Frølund, with Open and Closed Conformational States of the p1 B., Clausen, R., Chebib, M., et al (2012). (alpha)4(beta)(delta) Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More hydroxybutyric acid (GHB). Proceedings of the National Information] Academy of Sciences of the United States of America, 109(33), 13404-13409. [More Chebib, M., Hunter, L. (2012). The enantiomers of syn-2,3- Information] difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor. Chemical Communications, 48(6), 829- Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., 831. [More Tierney, L., Chebib, M. (2012). 2'-Methoxy-6-methylflavone: Information] A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information] Chebib, M., Le Breton, G., Standaert, R., Qian, H., et al (2011). 2-Aminoethyl Methylphosphonate, a Potent and Rapidly Acting Beinat, C., Banister, S., Prehn, S., Doddareddy, M., Hibbs, D., Antagonist of GABAA-p1 Receptors. Molecular Sako, M., Chebib, M., Tran, T., Al-Muhtasib, N., Xiao, Y., Pharmacology, 80(6), 965-978. [More the alpha7 nicotinic acetylcholine receptor (nAChR) agonist, Information] SEN12333. Bioorganic and Medicinal Chemistry Letters, 22(7), 2380-2384. [More Hanrahan, J., Chebib, M. (2011). 3-Hydroxy-2'-methoxy-6- Information] methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, Pharmacology, 82(12), 1971-1983. [More attachment of antagonists to the (alpha)7 nicotinic acetylcholine Information] receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3- Information] fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Communications, 47(28), 7956-7958. [More Differentiating Enantioselective Actions of GABOB: A Information] Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More E. (2011). Dengue virus PrM/M proteins fail to show pH- Information] dependent ion channel activity in Xenopus oocytes. Virology, 412(1), 83-90. [More G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for Information] exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information] Pharmacology, 163(2), 234-245. [More Information] GABA receptors in chick cornea. Molecular Vision, 18, 1107- 1114. opioid receptor and 2009 inhibits GIRK1/2 currents. Pharmacology, Biochemistry and Behavior, 99(3), 333-341. [More Vincler, M. (2009). Alpha9 nicotinic acetylcholine receptors Information] and the treatment of pain. Biochemical Pharmacology, 78(7), 693-702. [More (2011). Identification of Benzopyran-4-one Derivatives Information] (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340- Chebib, M., Gavande, N., Wong, K., Park, A., Premoli, I., 1346. [More (2009). Guanidino Acids Act as p1 GABAc Receptor Information] Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Information] Mewett, K., Johnston, G., Hanrahan, J., Chebib, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chebib, M., Hanrahan, J., Johnston, G. (2009). Neurologically- Chemistry, 3(2), 197-209. [More Hanrahan, J., Johnston, G., Kumar, R., Chebib, M. (2009). Information] Neurologically-active Compounds (III). Patent No. 1773740. Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Chebib, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Hanrahan, J., Chebib, M. (2011). Naringin directly activates Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., inwardly rectifying Hanrahan, J. (2009). Novel, potent and selective GABAC potassium channels at an overlapping binding site to tertiapin- antagonists inhibit myopia development and facilitate learning Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information] href="http://dx.doi.org/10.1124/jpet.108.146464">[More Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Information] Johnston, G., Hanrahan, J., Chebib, M. (2011). Novel Cyclic MacRaild, C., Illesinghe, J., vanLierop, B., Townsend, A., Phosphinic Acids as GABAC F Receptor Antagonists: Design, Chebib, M., Livett, B., Robinson, A., Norton, R. (2009). Synthesis, and Pharmacology. ACS Medicinal Chemistry Structure and Activity of (2,8)-Dicarba-(3,12)-cystino alpha- Letters, 2(1), 11-16. [More Analogue. Journal of Medicinal Chemistry, 52(3), 755-762. href="http://dx.doi.org/10.1021/jm8011504">[More Cheng, Z., Chebib, M., Schmidt, K. (2011). rho(1) GABA(C) Information] receptors are expressed in fibrous and cartilaginous layers of Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., chick sclera and located on sclera fibroblasts and chondrocytes. Hibbs, D., Chebib, M., Johnston, G., Hanrahan, J. (2009). Journal of Neurochemistry, 118(2), 281-287. [More Information] Medicinal Chemistry, 17(20), 7156-7173. [More Information] Quek, G., Lin, D., Halliday, J., Absalom, N., Ambrus, J., Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Thompson, A., Lochner, M., Lummis, S., McLeod, M., Chebib, Hanrahan, J., Chebib, M. (2009). The flavonoid glycosides, M. (2010). Identifying the Binding Site of Novel myricitrin, gossypin and naringin exert anxiolytic action in Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic mice. Neurochemical Research, 34(10), 1867-1875. [More 796-809. href="http://dx.doi.org/10.1021/cn100073x">[More Information] 2008 Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2010). Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Microwave-enhanced synthesis of 2,3,6-trisubstituted Chebib, M. (2008). A molecular basis for agonist and pyridazines: Application to four-step synthesis of gabazine (SR- antagonist actions at GABA(C) receptors. Chemical Biology 95531). Organic and Biomolecular Chemistry, 8(18), 4131- and Drug Design (Print), 71(4), 306-327. [More href="http://dx.doi.org/10.1111/j.1747- Information] 0285.2008.00642.x">[More Information] Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2010). Hinton, T., Chebib, M., Johnston, G. (2008). Enantioselective Neurochemicals for the Investigation of GABAc Receptors. actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2- Neurochemical Research, 35(12), 1970-1977. [More GABA(C) receptors. Bioorganic and Medicinal Chemistry Information] Letters, 18(1), 402-404. [More biological evaluation of a new family of constrained azabicyclic Information] homocholine analogues. Australian Journal of Chemistry, Fernandez, S., Mewett, K., Hanrahan, J., Chebib, M., Johnston, 63(5), 808-812. [More GABA(A) receptors with higher efficacy for the alpha(2) Information] subtype and anxiolytic action in mice. Neuropharmacology, Information] 55(5), 900-907. [M (2006). Modulation of ionotropic GABA receptors by natural ore Information] products of plant origin. Advances in Pharmacology, 54, 285- Kumar, R., Chebib, M., Hibbs, D., Kim, H., Johnston, G., 316. [More Information] acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of 2005 Medicinal Chemistry, 51(13), 3825-3840. [More Methylflavanone, a more efficacious positive allosteric Information] modulator of gamma-aminobutyric acid (GABA) action at Carland, J., Johnston, G., Chebib, M. (2008). Relative impact of human recombinant alpha2beta2gamma2L than at residues at the intracellular and extracellular ends of the human alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors GABA(C) rho1 receptor M2 domain on picrotoxinin activity. expressed in Xenopus oocytes. European Journal of European Journal of Pharmacology, 580(1), 27-35. [More href="http://dx.doi.org/10.1016/j.ejphar.2005.02.034">[More Information] Information] 2007 Crittenden, D., Chebib, M., Jordan, M. (2005). A quantitative structure-activity relationship investigation into agonist binding Chebib, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., at GABA C receptors. Computational and Theoretical Wooller, S., Johnston, G. (2007). (3- Chemistry, 755, 81-89. [Mor receptor antagonists. Neuropharmacology, 52(3), 779-787. href="http://dx.doi.org/10.1016/j.neuropharm.2006.09.014">[M Barker, D., Lin, D., Carland, J., Chu, C., Chebib, M., Brimble, ore Information] M., Savage, G., McLeod, M. (2005). Methyllycaconitine Small, D., Maksel, D., Kerr, M., Ng, J., Hou, X., Chu, C., analogues have mixed antagonist effects at nicotinic Mehrani, H., Unabia, S., Azari, M., Loiacono, R., Chebib, M., acetylcholine receptors. Bioorganic and Medicinal Chemistry, et al (2007). The β-amyloid protein of Alzheimer's disease 13(14), 4565-4575. [More acetylcholine receptor. Journal of Neurochemistry, 101(6), Information] 1527-1538. [More Information] Patent No. 6962907. 2006 Crittenden, D., Chebib, M., Jordan, M. (2005). Stabilization of zwitterions in solution: GABA analogues. The Journal of Hanrahan, J., Mewett, K., Chebib, M., Matos, S., Eliopoulos, Physical Chemistry A, 109(18), 4195-4201. [More Diastereoselective synthesis of (+/-)-(3- Information] aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Crittenden, D., Kumar, R., Hanrahan, J., Chebib, M., Jordan, M. Chemistry, 4(13), 2642-2649. [More phosphonic acid GABA analogues. The Journal of Physical Information] Chemistry A, 109(37), 8398-8409. [More Halliday, J., Chebib, M., Turner, P., McLeod, M. (2006). Information] Double-Mannich annulation of cyclic ketones using N,N- bis(ethoxymethyl) alkylamine reagents. Organic Letters, 8(15), 3399-3401. [More Carland, J., Moorhouse, A., Barry, P., Johnston, G., Chebib, M. Information] (2004). Charged Residues At The 2' Position Of Human GABAc �?1 Receptors Invert Ion Selectivity And Influence Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Open State Probability. Journal of Biological Chemistry, Johnston, G., Jordan, M., Chebib, M. (2006). Enantiomers of 279(52), 54153-54160. [More exert opposite effects at recombinant GABA(C) receptors. Information] Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Crittenden, D., Thompson, K., Chebib, M., Jordan, M. (2004). Information] Efficiency Considerations In The Construction Of Interpolated Potential Energy Surfaces For The Calculation Of Quantum Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Observables By Diffusion Monte Carlo. The Journal of Johnston, G. (2006). Mixed antagonistic effects of bilobalide at Physical Chemistry A, 121(20), 9844-9854. [More href="http://dx.doi.org/10.1016/j.neuroscience.2005.08.071">[ Information] More Information] Hall, B., Chebib, M., Hanrahan, J., Johnston, G. (2004). Johnston, G., Hanrahan, J., Chebib, M., Duke, R., Mewett, K. Flumazenil-independent positive modulation of g-aminobutyric (2006). Modulation of Ionotropic GABA Receptors by Natural acid action by 6-methylflavone at human recombinant a1h2g2L Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285- and a1h2 GABAA receptors. European Journal of 316). United States: Academic Press. [More eve&db=pubmed&dopt=Abstract&list_uids=17175819">[More Information] Chebib, M., Duke, R., Duke, C., Connor, M., Mewett, K., Chebib, M. (2004). Gabac Receptor Ion Channel. Clinical and Johnston, G. (2003). Convulsant actions of Calycanthine. Experimental Pharmacology and Physiology, 31, 800-804. [More Information] 2">[More Information] Chebib, M. (2004). GABAC receptor ion channels. Annual Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2003). Scientific Meeting of ASCEPT 2003, Australia: Blackwell GABAc receptors as drug targets. CNS and Neurological Publishers. Disorders, 2(4), 260-268. Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Johnston, G., Chebib, M. (2003). Phosphinic, phosphonic and Ginkgo Biloba, As Antagonists At Recombinant seleninic acid bioisosteres of isonipecotic acid as novel and Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of selective GABAc receptor antagonists. Neurochemistry Pharmacology, 494(2-3), 131-138. [More href="http://dx.doi.org/10.1016/S0197-0186(02)00162- Information] 6">[More Information] Chebib, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. Hanrahan, J., Chebib, M., Davucheron, N., Hall, B., Johnston, (2004). Ionotropic Gaba Receptors As Therapeutic Targets For G. (2003). Semisynthetic preparation of amentoflavone: a Memory And Sleep Disorders. Annual Reports in Medicinal negative modulator at gabaa receptors. Bioorganic and Chemistry, 39(1), 13-23. [More Information] 7">[More Information] Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Chebib, M. (2004). Mutations Of The 2' Proline 2002 In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Agonist Responses. Neuropharmacology, 46, 770-781. [M enhancement of wild type alpha-1 beta-2gamma-2l GABAa ore Information] receptors by diazepam, pentobarbitone and a steroid. 3rd Small, D., Fodero, L., Losic, D., Chu, C., Aguilar, M., Martin, College of Health Sciences Research Conference, Sydney: L., Chebib, M. (2004). Role of Aβ and the α7 nicotinic University of Sydney. acetylcholine receptor in regulating synaptic plasticity in Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Alzheimer's disease. International Journal of Peptide Research Wada, K. (2002). Effects of bilobalide and the sesquiterpene of and Therapeutics, 10(5-6), 401-404. [More GABAa modulators. 20th International Australasian Winter Information] Conference on Brain Research. Crittenden, D., Chebib, M., Jordan, M. (2004). Stabilization of Campbell, E., Chebib, M., Duke, R., Hall, B., Hanrahan, J., Zwitterions in Solution: γ-Aminobutyric Acid (GABA). The Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from Journal of Physical Chemistry A, 108(1), 203-211. [More GABA receptors. 5th Australia/Japan Symposium on Drug Information] Design and Development. Duke, R., Chebib, M., Hibbs, D., Mewett, K., Johnston, G. Duke, R., Chebib, M., Duke, C., Johnston, G., Roufogalis, B. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of (2002). Ginkgo biloba - food for the brain. New Zealand GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751. [More Information] Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Campbell, E., Chebib, M., Johnston, G. (2004). The Dietary Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha- Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance 1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. The Positive Modulation By Diazepam Of The Activation By Australian Health and Meldical Research Conference. GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Chebib, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2- Information] MeTACA) and (+/-)-trans-2- aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can 2003 differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard- 883-889. [More related analogues of THIP as GABAc antagonists. Bioorganic Information] and Medicinal Chemistry, 11(23), 4891-4896. [More 2001 Information] Hanrahan, J., Mewett, K., Chebib, M., Burden, P., Johnston, G. Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., (2001). An improved, versatile synthesis of the GABAc Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid receptors. European Journal of Pharmacology, 464(1), 1-8. [More Information] href="http://dx.doi.org/10.1039/b105989k">[More Information] Chebib, M. (2001). Novel agents acting on GABAc receptors: potenial cognitive enhancers. Chemistry in Australia, 69, no 9, 19-21. Chebib, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192. [More Information]