(12) United States Patent (10) Patent No.: US 7,304,086 B2 Schilling Et Al
USOO7304086B2 (12) United States Patent (10) Patent No.: US 7,304,086 B2 Schilling et al. (45) Date of Patent: *Dec. 4, 2007 (54) INHIBITORS OF GLUTAMINYL CYCLASE WO WOOO,53596 9, 2000 WO WO O1/34594 A1 5, 2001 (75) Inventors: Stephan Schilling, Halle/Saale (DE); WO WO O2, 13821 2, 2002 WO WO O2, 16318 A1 2, 2002 Mirko Buchholz, Halle/Saale (DE): WO WO O2O16318 A1 * 2/2002 Andre Johannes Niestroj, Sennewitz WO WO O2/O66459 A1 8, 2002 (DE); Ulrich Heiser, Halle/Saale (DE): WO WO O2/O92103 A1 11 2002 Hans-Ulrich Demuth, Halle/Saale (DE) WO WO O2O94813 A1 * 11/2002 WO WO 03/04.0174 A2 5, 2003 (73) Assignee: Probiodrug AG, Halle/Saale (DE) WO WO O3,O70732 8, 2003 WO WO O3068738 8, 2003 (*) Notice: Subject to any disclaimer, the term of this WO WO O30954.21 A1 * 11/2003 patent is extended or adjusted under 35 WO WO 2004O26815 A2 * 4, 2004 U.S.C. 154(b) by 20 days. WO WO 2004/089366 10, 2004 WO WO 2004/098591 A2 11 2004 This patent is Subject to a terminal dis WO WO 2004/098.625 A2 11 2004 claimer. OTHER PUBLICATIONS (21) Appl. No.: 11/051,760 Haley et al. Giorn. Ital. Chemioterap. (1962) 6-9 (No. 3), 213-24. Abstract from CAS attached. (22) Filed: Feb. 4, 2005 Hough et al. Pharmacology, Biochemistry and Behavior 1999, 65(1), 61-66. * Abstract from CAS attached.* (65) Prior Publication Data Morissette et al. Advanced Drug Delivery Reviews 2004, 56. US 2005/0215573 A1 Sep.
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