DOCSLIB.ORG

Ewg's Unacceptable List

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

EWG’S UNACCEPTABLE LIST: Personal Care Products EWG VERIFIEDTM products cannot contain any of the ingredients outlined in this document. EWG’s Unacceptable List 4/14/20 Substance/Ingredient Alternative name CAS Unacceptable reason (+/-) 2-(2,4- (+/-) 2-(2,4- 112281-77-3 Europe prohibits this ingredient in DICHLOROPHENYL)-3-(1H- Dichlorophenyl)-3- cosmetics. 1,2,4-TRIAZOL-1-YL)PROPYL- (1h-1,2,4-Triazol-1- 1,1,2,2- Yl)propyl-1,1,2,2- TETRAFLUOROETHYLETHER Tetrafluoroethyleth er (1_,4_,4A_,5_,8_,8A_)- (1_,4_,4a_,5_,8_,8a_ 465-73-6 Banned in Canadian cosmetics. 1,2,3,4,10,10-HEXACHLORO- )-1,2,3,4,10,10- 1,4,4A,5,8,8A-HEXAHYDRO- hexachloro- 1,4:5,8- 1,4,4a,5,8,8a- DIMETHANONAPHFTHALEN hexahydro-1,4:5,8- E dimethanonaphftha lene (1,1'-BIPHENYL)-4,4'-DIOL, 4,4'-Dihydroxy- 13049-13-3 The European Union lists this ingredient as 3,3',5,5'-TETRACHLORO- 3,3',5,5'- an endocrine disruptor (Category 1) tetrachlorobiphenyl (1,4'-BIPIPERIDINE)-4'- (1,4'-Bipiperidine)- 302-41-0 Europe prohibits this ingredient in CARBOXAMIDE, 1'-(3-CYANO- 4'-Carboxamide, 1'- cosmetics. 3,3-DIPHENYLPROPYL)- (3-Cyano-3,3- Diphenylpropyl)- (2-ethylhexyl)(hydrogenated (2- 308074-31-9 Some quaternary ammonium compounds tallow alkyl)dimethyl, Me Ethylhexyl)(Hydrog trigger asthma and may be toxic to human sulfates enated Tallow reproductive systems. Alkyl)dimethyl, Me Sulfates (3-CHLOROPHENYL)-(4- (3-chlorophenyl)-(4- 66938-41-8 Europe prohibits this ingredient in METHOXY-3- methoxy-3- cosmetics. NITROPHENYL)METHANONE nitrophenyl)methan one (4-HYDRAZINOPHENYL)-N- (4- 81880-96-8 Europe prohibits this ingredient in METHYLMETHANESULFONA hydrazinophenyl)-N- cosmetics. MIDE HYDROCHLORIDE methylmethanesulf onamide hydrochloride (6-(4-HYDROXY-3-(2- (6-(4-hydroxy-3-(2- 108225-03-2 Europe prohibits this ingredient in METHOXYPHENYLAZO)-2- methoxyphenylazo)- cosmetics. SULFONATO-7- 2-sulfonato-7- NAPHTHYLAMINO)-1,3,5- naphthylamino)- TRIAZIN-2,4- 1,3,5-triazin-2,4- DIYL)BIS[(AMINO-1- diyl)bis[(amino-1- METHYLETHYL)AMMONIUM] methylethyl)ammo FORMATE nium] formate (6-ALPHA)-PREGN-4-ENE- Medroxyprogestero The International Agency for Research on 3,20-DIONE, 17-(ACETYLOXY)- ne acetate Cancer lists this chemical as a Possible 6-METHYL- Human Carcinogen (Group 2B). Page 1 of 258 EWG’s Unacceptable List 4/14/20 Substance/Ingredient Alternative name CAS Unacceptable reason (Œ±) (±) 119738-06-6 Europe prohibits this ingredient in TETRAHYDROFURFURYL (R)- Tetrahydrofurfuryl cosmetics. 2-[4-(6- (r)-2-[4-(6- CHLOROQUINOXALIN-2- Chloroquinoxalin-2- YLOXY)PHENYLOXY]PROPIO Yloxy)phenyloxy]pr NATE opionate (Œ±) (œ±) 119738-06-6 The Global Harmonized System of chemical TETRAHYDROFURFURYL (R)- Tetrahydrofurfuryl hazards lists this chemical as 'Suspected of 2-[4-(6- (r)-2-[4-(6- causing genetic defects' (H341) CHLOROQUINOXALIN-2- Chloroquinoxalin-2- YLOXY)PHENYLOXY]PROPIO Yloxy)phenyloxy]pr NATE opionate (R)-_- (R)-_- 25383-07-7 Europe prohibits this ingredient in PHENYLETHYLAMMONIUM (- phenylethylammoni cosmetics. )-(1R, 2S)-(1,2- um (-)-(1R, 2S)-(1,2- EPOXYPROPYL)PHOSPHON epoxypropyl)phosp ATE MONOHYDRATE honate monohydrate (R)-5-BROMO-3-(1-METHYL-2- (R)-5-bromo-3-(1- 143322-57-0 Europe prohibits this ingredient in PYRROLIDINYL METHYL)-1H- methyl-2- cosmetics. INDOLE pyrrolidinyl methyl)- 1H-indole (S)-2,3-DIHYDRO-1H-INDOLE- (S)-2,3-dihydro-1H- 79815-20-6 Europe prohibits this ingredient in 2-CARBOXYLIC ACID indole-2-carboxylic cosmetics. acid (Z)-2-hydroxy-3-[(1-oxo-9- (z)-2-Hydroxy-3-[(1- 19467-38-0 Some quaternary ammonium compounds octadecenyl)oxy]propyltrimet Oxo-9- trigger asthma and may be toxic to human hylammonium chloride Octadecenyl)oxy]p reproductive systems. ropyltrimethylamm onium Chloride 1-(1- 1-(1- 65322-65-8 Europe prohibits this ingredient in NAPHTHYLMETHYL)QUINOLI naphthylmethyl)qui cosmetics. NIUM CHLORIDE nolinium chloride 1-(4-CHLOROPHENYL)-4,4- 1-(4-chlorophenyl)- 107534-96-3 Europe prohibits this ingredient in DIMETHYL-3-(1,2,4-TRIAZOL-1- 4,4-dimethyl-3- cosmetics. YLMETHYL)PENTAN-3-OL (1,2,4-triazol-1- ylmethyl)pentan-3- ol 1-Acetoxy-2- EWG Verified doesn't allow hair dye Methoxynaphthalene ingredients restricted in Europe. 1-ADAMANTANAMINE, Amantadine 665-66-7 California Prop65 lists this chemical as HYDROCHLORIDE hydrochloride known to cause developmental toxicity. 1-ALPHA-H,5-ALPHA-H- 1-Alpha-H,5-Alpha- 5796-31-6 Europe prohibits this ingredient in TROPANE-2-BETA- H-Tropane-2-Beta- cosmetics. CARBOXYLIC ACID, 3-BETA- Carboxylic Acid, 3- HYDROXY-, Beta-Hydroxy-, HYDROCHLORIDE Hydrochloride Page 2 of 258 EWG’s Unacceptable List 4/14/20 Substance/Ingredient Alternative name CAS Unacceptable reason 1-ALPHA-H,5-ALPHA-H- Cocaine 50-36-2 California Prop65 lists this chemical as TROPANE-2-BETA- known to cause developmental toxicity. CARBOXYLIC ACID, 3-BETA- HYDROXY-, METHYL ESTER, BENZOATE 1-ALPHA-H,5-ALPHA-H- 1-Alpha-H,5-Alpha- 53-21-4 Europe prohibits this ingredient in TROPANE-2-BETA- H-Tropane-2-Beta- cosmetics. CARBOXYLIC ACID, 3-BETA- Carboxylic Acid, 3- HYDROXY-, METHYL ESTER, Beta-Hydroxy-, BENZOATE Methyl Ester,benzoate 1-ALPHA-H,5-ALPHA-H- 1-alpha-H,5-alpha-H- 50-36-2 Europe prohibits this ingredient in TROPANE-2-BETA- Tropane-2-beta- cosmetics. CARBOXYLIC ACID, 3-BETA- carboxylic acid, 3- HYDROXY-, METHYL ESTER, beta-hydroxy-, BENZOATE methyl ester, benzoate 1-ALPHA-H,5-ALPHA-H- 1-Alpha-H,5-Alpha- 53-21-4 Europe prohibits this ingredient in TROPANE-2-BETA- H-Tropane-2-Beta- cosmetics. CARBOXYLIC ACID, 3-BETA- Carboxylic Acid, 3- HYDROXY-, METHYL Beta-Hydroxy-, ESTER,BENZOATE Methyl Ester,benzoate 1-ALPHA-H,5-ALPHA-H- 1-Alpha-H,5-Alpha- 86-13-5 Banned in Canadian cosmetics. TROPANE, 3-ALPHA- H-Tropane, 3-Alpha- (DIPHENYLMETHOXY)- (diphenylmethoxy)- 1-Beta-Hydroxyethyl-2,4- 14572-93-1 Europe bans this ingredient in cosmetics. Diaminobenzene 1-BROMO-3,4,5- 1-bromo-3,4,5- 138526-69-9 Europe prohibits this ingredient in TRIFLUOROBENZENE trifluorobenzene cosmetics. 1-BROMOPROPANE 1-Bromopropane (1- 106-94-5 California Prop65 lists this chemical as BP) known to cause developmental toxicity. 1-BROMOPROPANE 1-Bromopropane 106-94-5 Europe prohibits this ingredient in cosmetics. 1-BUTANAMINE, N-BUTYL-N- 1-BUTANAMINE, N- 924-16-3 Banned in Canadian cosmetics. NITROSO- BUTYL-N-NITROSO- 1-BUTANAMINE, N-BUTYL-N- N-Nitrosodi-n- The International Agency for Research on NITROSO- butylamine Cancer lists this chemical as a Possible Human Carcinogen (Group 2B). 1-BUTANAMINE, N-BUTYL-N- N-Nitroso-di-n- 924-16-3 The U.S. Environmental Protection Agency NITROSO- butylamine has identified this chemical as a probable human carcinogen (B2). 1-CHLORO-2,3- 1-chloro-2,3- 106-89-8 Banned in Canadian cosmetics. EPOXYPROPANE epoxypropane 1-CHLORO-2,3- Epichlorohydrin (1- 106-89-8 The European Union lists this ingredient as EPOXYPROPANE chloro-2,3- an endocrine disruptor (Category 1) epoxypropane) 1-CHLORO-2,3- Epichlorohydrin 106-89-8 The U.S. Environmental Protection Agency EPOXYPROPANE has identified this chemical as a probable human carcinogen (B2). Page 3 of 258 EWG’s Unacceptable List 4/14/20 Substance/Ingredient Alternative name CAS Unacceptable reason 1-CHLORO-4- 1-chloro-4- 100-00-5 California Prop65 lists this chemical as NITROBENZENE nitrobenzene known to cause cancer. 1-CYCLOHEXENE, 4-VINYL- 4-Vinylcyclohexene The International Agency for Research on Cancer lists this chemical as a Possible Human Carcinogen (Group 2B). 1-CYCLOPROPYL-6,7- 1-cyclopropyl-6,7- 93107-30-3 The Global Harmonized System of chemical DIFLUORO-1,4-DIHYDRO-4- difluoro-1,4-dihydro- hazards lists this chemical as 'Suspected of OXOQUINOLINE-3- 4-oxoquinoline-3- damaging fertility or the unborn child' CARBOXYLIC ACID carboxylic acid (H361) 1-ETHYL-1- 1-ethyl-1- 65756-41-4 Europe prohibits this ingredient in METHYLMORPHOLINIUM methylmorpholiniu cosmetics. BROMIDE m bromide 1-ETHYL-1- 1-ethyl-1- 69227-51-6 Europe prohibits this ingredient in METHYLPYRROLIDINIUM methylpyrrolidiniu cosmetics. BROMIDE m bromide 1-Methyl-2,4,5- 1124-09-0 Europe bans this ingredient in cosmetics. Trihydroxybenzene And Its Salts 1-METHYL-3-NITRO-1- 1-methyl-3-nitro-1- 70-25-7 Europe prohibits this ingredient in NITROSOGUANIDINE nitrosoguanidine cosmetics. 1-METHYL-3-NITRO-1- N-Methyl-N´-nitro- The International Agency for Research on NITROSOGUANIDINE N-nitrosoguanidine Cancer lists this chemical as a Probable (MNNG) Human Carcinogen (Group 2A). 1-METHYL-3-NITRO-1- N-Methyl-N'-nitro-N- 70-25-7 The U.S. National Toxicology Program has NITROSOGUANIDINE nitrosoguanidine identified this chemical as reasonably anticipated human carcinogen. 1-NAPHTHALENEHEPTANOIC Pravastatin sodium 81131-70-6 California Prop65 lists this chemical as ACID, 1,2,6,7,8,8A- known to cause developmental toxicity. HEXAHYDRO-2-METHYL-8-(2- METHYL-1-OXOBUTOXY)- BETA, 1-NAPHTHALENESULFONIC 3-Hydroxy-4-[(2- 16279-54-2 Europe bans this ingredient in hair dyes. ACID, 3-HYDROXY-4-((2- Hydroxynaphthyl)a HYDROXY-1- zo]-7- NAPHTHALENYL)AZO)-7- Nitronaphthalene-1- NITRO- sulphonic Acid And Its Salts 1-NAPHTHALENESULFONIC 1- 16279-54-2 Europe prohibits this ingredient in ACID, 3-HYDROXY-4-((2- Naphthalenesulfoni cosmetics. HYDROXY-1- c Acid, 3-Hydroxy- NAPHTHALENYL)AZO)-7- 4-((2-Hydroxy-1- NITRO- Naphthalenyl)azo)- 7-Nitro- 1-NAPHTHALENESULFONIC 1- 573-58-0 Europe prohibits this ingredient in ACID, 3,3'-(4,4'- Naphthalenesulfoni cosmetics. BIPHENYLENEBIS(AZO))BIS( c Acid, 3,3'-(4,4'- 4-AMINO-, DISODIUM SALT Biphenylenebis(Azo ))bis(4-Amino-, Disodium Salt Page 4 of 258 EWG’s Unacceptable List 4/14/20 Substance/Ingredient Alternative name CAS Unacceptable reason 1-NAPHTHOL 1-Naphthol 90-15-3 EWG Verified doesn't allow hair dye ingredients restricted in Europe. 1-NAPHTHYLAMINE 1-naphthylamine 134-32-7 California Prop65 lists this chemical as known to cause cancer.
Recommended publications
  • Dielectric Behavior of Α-Ag2wo4 and Its Huge Dielectric Loss Tangent 1. Introduction

    Dielectric Behavior of Α-Ag2wo4 and Its Huge Dielectric Loss Tangent 1. Introduction

    Materials Research. 2019; 22(4): e20190058 DOI: http://dx.doi.org/10.1590/1980-5373-MR-2019-0058 Dielectric Behavior of α-Ag2WO4 and its Huge Dielectric Loss Tangent Natalia Jacomacia* , Euripedes Silva Juniora , Fernando Modesto Borges de Oliveirab , Elson Longob , Maria Aparecida Zaghetea aInstituto de Química, Universidade Estadual Paulista (Unesp), 14800-060, Araraquara, SP, Brasil bDepartamento de Química, Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, SP, Brasil Received: January 21, 2019; Revised: May 08, 2019; Accepted: June 29, 2019 The microwave-assisted hydrothermal method was used to obtain α-Ag2WO4. Rietveld refinement confirmed that α-Ag2WO4 is stable in the orthorhombic phase, without secondary phase. However, field- effect scanning electron microscope analysis showed that α-Ag2WO4 nanorods surfaces contain silver nanoparticles, confirmed by the X-ray photoelectron spectroscopy by the peak observed at 374.39 eV. In addition to metallic Ag, other Ag oxidation states were also observed on the surface. Hence, Ag (I) as Ag2O and Ag (I) as Ag2WO4 also were identified. DC measurements exhibited a high capacity of charge storage, nevertheless, with a large loss tangent (0.12 µC.cm-2.V-1) and no residual polarization for the voltage range between -100 V and +100 V. AC measurements at frequencies less than 275 Hz, revealed that ionic polarization is dominant, whereas at frequencies higher than 275 Hz, the electronic behavior predominates. The potential of electromagnetic energy conversion in thermal was observed from loss tangent analysis. Keywords: Silver tungstate nanorods, dielectric behavior, ionic and electronic polarization. 1. Introduction Among transition metal tungstates, silver tungstate (Ag2WO4) has attracted the attention of the scientific and technological Tungsten-silver materials are known to exhibit very good community because of its chemical stability, easy synthesis15, erosion resistance properties in low voltage.
  • Aldrich FT-IR Collection Edition I Library

    Aldrich FT-IR Collection Edition I Library

    Aldrich FT-IR Collection Edition I Library Library Listing – 10,505 spectra This library is the original FT-IR spectral collection from Aldrich. It includes a wide variety of pure chemical compounds found in the Aldrich Handbook of Fine Chemicals. The Aldrich Collection of FT-IR Spectra Edition I library contains spectra of 10,505 pure compounds and is a subset of the Aldrich Collection of FT-IR Spectra Edition II library. All spectra were acquired by Sigma-Aldrich Co. and were processed by Thermo Fisher Scientific. Eight smaller Aldrich Material Specific Sub-Libraries are also available. Aldrich FT-IR Collection Edition I Index Compound Name Index Compound Name 3515 ((1R)-(ENDO,ANTI))-(+)-3- 928 (+)-LIMONENE OXIDE, 97%, BROMOCAMPHOR-8- SULFONIC MIXTURE OF CIS AND TRANS ACID, AMMONIUM SALT 209 (+)-LONGIFOLENE, 98+% 1708 ((1R)-ENDO)-(+)-3- 2283 (+)-MURAMIC ACID HYDRATE, BROMOCAMPHOR, 98% 98% 3516 ((1S)-(ENDO,ANTI))-(-)-3- 2966 (+)-N,N'- BROMOCAMPHOR-8- SULFONIC DIALLYLTARTARDIAMIDE, 99+% ACID, AMMONIUM SALT 2976 (+)-N-ACETYLMURAMIC ACID, 644 ((1S)-ENDO)-(-)-BORNEOL, 99% 97% 9587 (+)-11ALPHA-HYDROXY-17ALPHA- 965 (+)-NOE-LACTOL DIMER, 99+% METHYLTESTOSTERONE 5127 (+)-P-BROMOTETRAMISOLE 9590 (+)-11ALPHA- OXALATE, 99% HYDROXYPROGESTERONE, 95% 661 (+)-P-MENTH-1-EN-9-OL, 97%, 9588 (+)-17-METHYLTESTOSTERONE, MIXTURE OF ISOMERS 99% 730 (+)-PERSEITOL 8681 (+)-2'-DEOXYURIDINE, 99+% 7913 (+)-PILOCARPINE 7591 (+)-2,3-O-ISOPROPYLIDENE-2,3- HYDROCHLORIDE, 99% DIHYDROXY- 1,4- 5844 (+)-RUTIN HYDRATE, 95% BIS(DIPHENYLPHOSPHINO)BUT 9571 (+)-STIGMASTANOL
  • (12) Patent Application Publication (10) Pub. No.: US 2009/0156618 A1 Tollefson (43) Pub

    (12) Patent Application Publication (10) Pub. No.: US 2009/0156618 A1 Tollefson (43) Pub

    US 20090156618A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0156618 A1 Tollefson (43) Pub. Date: Jun. 18, 2009 (54) 1-(1-(2-ETHOXYETHYL)-3-ETHYL-7- Related U.S. Application Data (4-METHYLPYRIDIN-2-YLAMINO) - 1H-PYRAZOLO 4.3-D PYRIMIDIN-5-YL) (60) Provisional application No. 60/735,320, filed on Nov. PPERDINE-4-CARBOXYLIC ACID AND 10, 2005. SALTS THEREOF Publication Classification (51) Int. Cl. (75) Inventor: Michael B. Tollefson, Dardenne A 6LX 3/59 (2006.01) Prairie, MO (US) C07D 487/04 (2006.01) A6IP 9/12 (2006.01) A6IP 25/00 (2006.01) Correspondence Address: A6IP 9/00 (2006.01) PFZER INC. PATENT DEPARTMENT, Bld 114 M/S 114, (52) U.S. Cl. ...................................... 514/262.1; 54.4/262 EASTERN PONT ROAD (57) ABSTRACT GROTON, CT 06340 (US) The present invention comprises 1-(1-(2-ethoxyethyl)-3- ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo 4.3-d (73) Assignee: Pfizer Inc pyrimidin-5-yl)piperidine-4-carboxylic acid and its salts. The invention further comprises pharmaceutical composi tions, methods of treatment, and synthetic methods relating to (21) Appl. No.: 111558,306 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2- ylamino)-1H-pyrazolo 4.3-dipyrimidin-5-yl)piperidine-4- (22) Filed: Nov. 9, 2006 carboxylic acid and its salts. Patent Application Publication Jun. 18, 2009 Sheet 2 of 2 US 2009/0156618 A1 "SOIHZ US 2009/0156618 A1 Jun. 18, 2009 1-(1-(2-ETHOXYETHYL)-3-ETHYL-7- 1H-pyrazolo 4,3-dipyrimidin-5-yl)piperidine-4-carboxylic (4-METHYLPYRIDIN-2-YLAMINO) - acid and its pharmaceutically acceptable salts.
  • Standard X-Ray Diffraction Powder Patterns

    Standard X-Ray Diffraction Powder Patterns

    NBS MONOGRAPH 25 — SECTION 1 Standard X-ray Diffraction U.S. DEPARTMENT OF COMMERCE NATIONAL BUREAU OF STANDARDS THE NATIONAL BUREAU OF STANDARDS Functions and Activities The functions of the National Bureau of Standards are set forth in the Act of Congress, March 3, 1901, as amended by Congress in Public Law 619, 1950. These include the development and maintenance of the national standards of measurement and the provision of means and methods for making measurements consistent with these standards; the determination of physical constants and properties of materials; the development of methods and instruments for testing materials, devices, and structures; advisory services to government agencies on scien- tific and technical problems; invention and development of devices to serve special needs of the Government; and the development of standard practices, codes, and specifications. The work includes basic and applied research, development, engineering, instrumentation, testing, evaluation, calibration services, and various consultation and information services. Research projects are also performed for other government agencies when the work relates to and supplements the basic program of the Bureau or when the Bureau's unique competence is required. The scope of activities is suggested by the listing of divisions and sections on the inside of the back cover. Publications The results of the Bureau's research are published either in the Bureau's own series of publications or in the journals of professional and scientific societies. The Bureau itself publishes three periodicals available from the Government Printing Office: The Journal of Research, published in four separate sections, presents complete scientific and technical papers; the Technical News Bulletin presents summary and preliminary reports on work in progress; and Basic Radio Propagation Predictions provides data for determining the best frequencies to use for radio communications throughout the world.
  • Campro Catalog Stable Isotope

    Campro Catalog Stable Isotope

    Introduction & Welcome Dear Valued Customer, We are pleased to present to you our Stable Isotopes Catalog which contains more than three thousand (3000) high quality labeled compounds. You will find new additions that are beneficial for your research. Campro Scientific is proud to work together with Isotec, Inc. for the distribution and marketing of their stable isotopes. We have been working with Isotec for more than twenty years and know that their products meet the highest standard. Campro Scientific was founded in 1981 and we provide services to some of the most prestigious universities, research institutes and laboratories throughout Europe. We are a research-oriented company specialized in supporting the requirements of the scientific community. We are the exclusive distributor of some of the world’s leading producers of research chemicals, radioisotopes, stable isotopes and environmental standards. We understand the requirements of our customers, and work every day to fulfill them. In working with us you are guaranteed to receive: - Excellent customer service - High quality products - Dependable service - Efficient distribution The highly educated staff at Campro’s headquarters and sales office is ready to assist you with your questions and product requirements. Feel free to call us at any time. Sincerely, Dr. Ahmad Rajabi General Manager 180/280 = unlabeled 185/285 = 15N labeled 181/281 = double labeled (13C+15N, 13C+D, 15N+18O etc.) 186/286 = 12C labeled 182/282 = d labeled 187/287 = 17O labeled 183/283 = 13C labeleld 188/288 = 18O labeled 184/284 = 16O labeled, 14N labeled 189/289 = Noble Gases Table of Contents Ordering Information.................................................................................................. page 4 - 5 Packaging Information ..............................................................................................
  • XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta

    XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta

    Clinical Toxicology ISSN: 1556-3650 (Print) 1556-9519 (Online) Journal homepage: http://www.tandfonline.com/loi/ictx20 XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta To cite this article: (2015) XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta, Clinical Toxicology, 53:4, 233-403, DOI: 10.3109/15563650.2015.1024953 To link to this article: http://dx.doi.org/10.3109/15563650.2015.1024953 Published online: 26 Mar 2015. Submit your article to this journal Article views: 3422 View related articles View Crossmark data Citing articles: 2 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ictx20 Download by: [UPSTATE Medical University Health Sciences Library] Date: 28 December 2016, At: 10:31 Clinical Toxicology (2015), 53, 233–403 Copyright © 2015 Informa Healthcare USA, Inc. ISSN: 1556-3650 print / 1556-9519 online DOI: 10.3109/15563650.2015.1024953 ABSTRACTS XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian ’ s, Malta 1. Modelling dose-concentration-response Introduction: The American Association of Poison Control Cen- ters (AAPCC) published its fi rst annual report in 1983. Call data Ursula Gundert-Remy from sixteen US poison centers was chronicled in that report. Seven submitted data for the entire year. By July 2000, 63 centers Institute for Clinical Pharmacology and Toxicology, Charit é were part of the national poison center system, but only 59 submit- Medical School, Berlin, Germany ted data for the full year.
  • Theoretical Problem Icho 2018

    Theoretical Problem Icho 2018

    19th – 29th July 2018 Bratislava, SLOVAKIA Prague, CZECH REPUBLIC www.50icho.eu THEORETICAL PROBLEMS Country: Name as in passport: Student code: Language: 50th IChO 2018 International Chemistry Olympiad SLOVAKIA & CZECH REPUBLIC BACK TO WHERE IT ALL BEGAN XXX-X INTERNATIONAL CHEMISTRY OLYMPIAD / SLOVAKIA & CZECH REPUBLIC, 2018 Table of Contents Instructions ...................................................................................................................................... 2 Physical constants and equations ................................................................................................... 3 Problem 1. DNA .............................................................................................................................. 5 Problem 2. Repatriation of remains in the middle ages .................................................................. 14 Problem 3. Emerging electro-mobility ............................................................................................ 22 Problem 4. Column chromatography of radioactive copper ........................................................... 30 Problem 5. Bohemian garnet ......................................................................................................... 34 Problem 6. Let’s go mushrooming ................................................................................................. 41 Problem 7. Cidofovir ...................................................................................................................... 47
  • (12) United States Patent (10) Patent No.: US 9,394,315 B2 Aicher Et Al

    (12) United States Patent (10) Patent No.: US 9,394,315 B2 Aicher Et Al

    USOO93943 15B2 (12) United States Patent (10) Patent No.: US 9,394,315 B2 Aicher et al. (45) Date of Patent: Jul.19, 2016 (54) TETRAHYDROI18NAPHTHYRIDINE 6,605,634 B2 8, 2003 Zablocki et al. SULFONAMIDE AND RELATED 6,638,960 B2 10/2003 Assmann et al. 6,683,091 B2 1/2004 Asberomet al. COMPOUNDS FOR USEAS AGONSTS OF 6,828,344 B1 12/2004 Seehra et al. RORY AND THE TREATMENT OF DISEASE 7,084, 176 B2 8, 2006 Morie et al. 7,138.401 B2 11/2006 Kasibhatla et al. (71) Applicant: Lycera Corporation, Ann Arbor, MI 7,329,675 B2 2/2008 Cox et al. 7,420,059 B2 9, 2008 O'Connor et al. (US) 7,482.342 B2 1/2009 D’Orchymont et al. 7,569,571 B2 8/2009 Dong et al. (72) Inventors: Thomas D. Aicher, Ann Arbor, MI (US); 7,696,200 B2 4/2010 Ackermann et al. Peter L. Toogood, Ann Arbor, MI (US); 7,713.996 B2 5/2010 Ackermann et al. Xiao Hu, Northville, MI (US) 7,741,495 B2 6, 2010 Liou et al. 7,799,933 B2 9/2010 Ceccarelli et al. (73) Assignee: Lycera Corporation, Ann Arbor, MI 2006,0004000 A1 1/2006 D'Orchymont et al. 2006/010O230 A1 5, 2006 Bischoff et al. (US) 2007/0010537 A1 1/2007 Hamamura et al. 2007/OO 10670 A1 1/2007 Hirata et al. (*) Notice: Subject to any disclaimer, the term of this 2007/0049556 A1 3/2007 Zhang et al. patent is extended or adjusted under 35 2007/0060567 A1 3/2007 Ackermann et al.
  • Effect of Theophylline and Enprofylline on Bronchial Hyperresponsiveness

    Effect of Theophylline and Enprofylline on Bronchial Hyperresponsiveness

    Thorax: first published as 10.1136/thx.44.12.1022 on 1 December 1989. Downloaded from Thorax 1989;44:1022-1026 Effect of theophylline and enprofylline on bronchial hyperresponsiveness G H KOETER, J KRAAN, M BOORSMA, J H G JONKMAN, TH W VAN DER MARK From the Department ofPulmonology and Lung Function, University Hospital, Groningen; Pharma Bio Research, Assen; and Astra Pharmaceutica, Rijswijk, The Netherlands ABSTRACT The effect of increasing intravenous doses of theophylline and enprofylline, a new xanthine derivative, on bronchial responsiveness to methacholine was studied in eight asthmatic patients. Methacholine provocations were carried out on three days before and after increasing doses of theophylline, enprofylline, and placebo, a double blind study design being used. Methacholine responsiveness was determined as the provocative concentration of methacholine causing a fall of 20% in FEV, (PC20). The patients were characterised pharmacokinetically before the main study to provide an individual dosage scheme for each patient that would provide rapid steady state plasma concentration plateaus of 5, 10, and 15 mg/l for theophylline and 1 25, 2 5, and 3-75 mg/l for enprofylline. Dose increments in the main study were given at 90 minute intervals. FEV, showed a small progressive decrease after placebo; it remained high in relation to placebo after both drugs and this effect was dose related. Methacholine PC20 values decreased after placebo; mean values were (maximum difference 2-0 and 1 7 higher after theophylline and enprofylline than after placebo copyright. doubling doses of methacholine); the effect of both drugs was dose related. Thus enprofylline and theophylline when given intravenously cause a small dose related increase in FEV1 and methacholine PC20 when compared with placebo.
  • Synthesis of Optically Pure Macroheterocycles with 2,6-Pyridinedicarboxylic and Adipic Acid Fragments from ∆3-Carene

    Synthesis of Optically Pure Macroheterocycles with 2,6-Pyridinedicarboxylic and Adipic Acid Fragments from ∆3-Carene

    Macrolides Paper Макролиды Статья DOI: 10.6060/mhc190660y Synthesis of Optically Pure Macroheterocycles with 2,6-Pyridinedicarboxylic and Adipic Acid Fragments from ∆3-Carene Marina P. Yakovleva,@ Kseniya S. Denisova, Galina R. Mingaleeva, Valentina A. Vydrina, and Gumer Yu. Ishmuratov Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 450054 Ufa, Russia @Corresponding author E-mail: [email protected] Based on the available natural monoterpene ∆3-carene we have developed the synthesis of four optically pure macroheterocycles with ester and dihydrazide fragments through the intermediate 1-((1S,3R)-3-(2-hydroxyethyl- 2,2-dimethylcyclopropyl)propan-2-one using its [2+1]-interaction with dichloranhydrides of adipic or 2,6-pyridinedicarboxylic acids and [1+1]-condensation of the obtained α,ω-diketodiesters with dihydrazides of adipic or 2,6-pyridinedicarboxylic acids. The structure of new compounds was confirmed by IR and NMR spectroscopy and mass spectrometry. Keywords: 3-Carenes, ozonolysis, sodium hypochlorite, macroheterocycles with ester and dihydrazide fragments, [2+1] and [1+1] condensations, synthesis. Синтез оптически чистых макрогетероциклов со сложноэфирными и дигидразидными фрагментами адипиновой и 2,6-пиридиндикарбоновой кислот из D3-карена М. П. Яковлева,@ К. С. Денисова, Г. Р. Мингалеева, В. А. Выдрина, Г. Ю. Ишмуратов Уфимский Институт химии – обособленное структурное подразделение Федерального бюджетного научного учреждения Уфимского федерального исследовательского центра Российской академии
  • High-Throughput H295R Steroidogenesis Assay: Utility As an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis Derik E

    High-Throughput H295R Steroidogenesis Assay: Utility As an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis Derik E

    High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis Derik E. Haggard ORISE Postdoctoral Fellow National Center for Computational Toxicology Computational Toxicology Communities of Practice Dec. 14th, 2017 The views expressed in this presentation are those of the author and do not necessarily reflect the views or policies of the U.S. EPA Outline • Background • Objectives • Assay Background • Methods and Results 1. Evaluation of the HT-H295R assay 2. Development of a quantitative prioritization metric for the HT-H295R assay data • Summary and Conclusions 2 Steroid Hormone Biosynthesis & Metabolism • Proper steroidogenesis is essential: • In utero for fetal development • In adults for reproductive function • Disruption can result in congenital adrenal hyperplasia, sterility, prenatal virilization, salt wasting, etc. • >90% of steroidogenesis occurs in the gonads • Leydig cells (males) or follicular cells (females) • Adrenal gland (corticosteroids) 3 https://www.pharmacorama.com/en/Sections/Androgen_steroid_hormones.php US EPA Endocrine Disruptor Screening Program (EDSP) • EDSP mandated to screen chemicals for endocrine activity (estrogen, androgen, thyroid) • Initial tiered screen relied on low-throughput assays • Modernization of EDSP (EDSP21) to use high-throughput and computational methods • Prioritize the universe of EDSP chemicals for endocrine bioactivity • Altering hormone levels via disruption of biosynthesis or metabolism can also contribute
  • Pyridoxine in Clinical Toxicology: a Review Philippe Lheureux, Andrea Penaloza and Mireille Gris

    Pyridoxine in Clinical Toxicology: a Review Philippe Lheureux, Andrea Penaloza and Mireille Gris

    78 Review Pyridoxine in clinical toxicology: a review Philippe Lheureux, Andrea Penaloza and Mireille Gris Pyridoxine (vitamin B6) is a co-factor in many enzymatic controversial. This paper reviews the various indications pathways involved in amino acid metabolism: the main of pyridoxine in clinical toxicology and the supporting biologically active form is pyridoxal 5-phosphate. literature. The potential adverse effects of excessive Pyridoxine has been used as an antidote in acute pyridoxine dosage will also be summarized. intoxications, including isoniazid overdose, Gyromitra European Journal of Emergency Medicine 12:78–85 mushroom or false morrel (monomethylhydrazine) c 2005 Lippincott Williams & Wilkins. poisoning and hydrazine exposure. It is also recommended as a co-factor to improve the conversion of glyoxylic acid European Journal of Emergency Medicine 2005, 12:78–85 into glycine in ethylene glycol poisoning. Other indications Keywords: Antidotes, crimidin, drug-induced neuropathy, ethylene glycol, are recommended by some sources (for example crimidine hydrazine, isoniazid, metadoxine, pyridoxine poisoning, zipeprol and theophylline-induced seizures, adjunct to d-penicillamine chelation), without significant Department of Emergency Medicine, Erasme University Hospital, Brussels, Belgium. supporting data. The value of pyridoxine or its congener Correspondence to Philippe Lheureux, Department of Emergency Medicine, metadoxine as an agent for hastening ethanol metabolism Erasme University Hospital, 808 route de Lennik, 1070 Brussels, Belgium. or improving vigilance in acute alcohol intoxication is E-mail: [email protected] Introduction ing. More controversial issues include alcohol intoxication Pyridoxine or vitamin B6 is a highly water-soluble and zipeprol or theophylline-induced seizures. vitamin. Its main biologically active form is a phosphate ester of its aldehyde form, pyridoxal 5-phosphate (P5P).