October 25, 2016 u vol. 113 u no. 43

From the Cover

12006 Mechanism of seabird plunge-dives E6639 Antigen availability and antibody response 12071 Flood frequency and hurricanes 12120 Resource scarcity and aggression in hunter-gatherers 12168 Model of chromosome structure

Contents

THIS WEEK IN PNAS Cover image: Pictured is a high-speed 11979 In This Issue image of a northern gannet diving into water. Brian Chang et al. studied how seabirds, especially gannets, can LETTERS (ONLINE ONLY) plunge-dive into water at high speeds E6548 Psychologically authentic versus inauthentic replication attempts without sustaining neck injuries. The Christopher J. Bryan, Gregory M. Walton, and Carol S. Dweck authors analyzed morphological features E6549 Reply to Bryan et al.: Variation in context unlikely explanation of nonrobustness from a gannet specimen and data from of noun versus verb results controlled experimental dives, and Alan S. Gerber, Gregory A. Huber, Daniel R. Biggers, and David J. Hendry found that hydrodynamic drag on the heads of diving seabirds might induce E6551 Weak support for disappearance and restricted emergence/persistence of buckling in the birds’ necks, and that highly pathogenic influenza A in North American waterfowl strong neck muscles allow the birds to Andrew M. Ramey, Erica Spackman, Mia Kim-Torchetti, and Thomas J. DeLiberto survive the compression forces. See the E6553 Reply to Ramey et al.: Let time be the arbiter article by Chang et al. on pages 12006– Scott Krauss, David E. Stallknecht, Richard D. Slemons, Andrew S. Bowman, Rebecca L. 12011. Image courtesy of Brian Chang Poulson, Jacqueline M. Nolting, James P. Knowles, and Robert G. Webster and Sunghwan Jung. SCIENCE AND CULTURE—How science intersects with culture 11982 Avant-garde outreach, with science rigor Amber Dance

CORE CONCEPTS—A brief introduction to emerging topics in science 11984 Chimeras keep courting controversy Elie Dolgin

COMMENTARIES 11986 Magnetite in the human body: Biogenic vs. anthropogenic Reto Giere´ See companion article on page 10797 in issue 39 of volume 113 11988 How essential fats affect bird performance and link aquatic ecosystems and terrestrial consumers Carlos Martinez del Rio and Scott R. McWilliams See companion article on page 10920 in issue 39 of volume 113 11991 Three-dimensional chromosome structures from energy landscape Gamze Gu¨rsoy and Jie Liang See companion article on page 12168

Free online through the PNAS open access option. PNAS u October 25, 2016 u vol. 113 u no. 43 u iii–vii Downloaded by guest on September 24, 2021 12162 Graded activation and free energy landscapes of PNAS PLUS a muscarinic G-protein–coupled receptor 11994 Significance Statements Yinglong Miao and J. Andrew McCammon Brief statements written by the authors about the significance of their papers. EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 12053 Reduced anthropogenic aerosol radiative forcing INAUGURAL ARTICLE caused by biogenic new particle formation Hamish Gordon, Kamalika Sengupta, Alexandru Rap, Jonathan 11998 Tilting the balance between RNA interference and Leishmania Duplissy, Carla Frege, Christina Williamson, Martin Heinritzi, replication eradicates RNA virus 1 Mario Simon, Chao Yan, Joa˜o Almeida, Jasmin Tro¨stl, Tuomo and mitigates the inflammatory response Nieminen, Ismael K. Ortega, Robert Wagner, Eimear M. Dunne, Erin A. Brettmann, Jahangheer S. Shaik, Haroun Zangger, Alexey Adamov, Antonio Amorim, Anne-Kathrin Bernhammer, Lon-Fye Lye, F. Matthew Kuhlmann, Natalia S. Akopyants, Federico Bianchi, Martin Breitenlechner, Sophia Brilke, Dayna M. Oschwald, Katherine L. Owens, Suzanne M. Xuemeng Chen, Jill S. Craven, Antonio Dias, Sebastian Ehrhart, Hickerson, Catherine Ronet, Nicolas Fasel, Lukas Fischer, Richard C. Flagan, Alessandro Franchin, Claudia and Stephen M. Beverley Fuchs, Roberto Guida, Jani Hakala, Christopher R. Hoyle, Tuija Jokinen, Heikki Junninen, Juha Kangasluoma, Jaeseok Kim, Jasper Kirkby, Manuel Krapf, Andreas Ku¨rten, Ari Laaksonen, PHYSICAL SCIENCES Katrianne Lehtipalo, Vladimir Makhmutov, Serge Mathot, Ugo Molteni, Sarah A. Monks, Antti Onnela, Otso Pera¨kyla¨, Felix APPLIED MATHEMATICS Piel, Tuukka Peta¨ja¨, Arnaud P. Praplan, Kirsty J. Pringle, E6630 Architecture of a minimal signaling pathway explains Nigel A. D. Richards, Matti P. Rissanen, Linda Rondo, Nina the T-cell response to a 1 million-fold variation in Sarnela, Siegfried Schobesberger, Catherine E. Scott, John H. antigen affinity and dose Seinfeld, Sangeeta Sharma, Mikko Sipila¨, Gerhard Steiner, Yuri Stozhkov, Frank Stratmann, Antonio Tome´, Annele Virtanen, Melissa Lever, Hong-Sheng Lim, Philipp Kruger, John Nguyen, Alexander Lucas Vogel, Andrea C. Wagner, Paul E. Wagner, Nicola Trendel, Enas Abu-Shah, Philip Kumar Maini, Philip Anton Ernest Weingartner, Daniela Wimmer, Paul M. Winkler, Penglin van der Merwe, and Omer Dushek Ye, Xuan Zhang, Armin Hansel, Josef Dommen, Neil M. Donahue, Douglas R. Worsnop, Urs Baltensperger, Markku APPLIED PHYSICAL SCIENCES Kulmala, Joachim Curtius, and Kenneth S. Carslaw 12006 How seabirds plunge-dive without injuries 12059 Thermogenic methane release as a cause for the long Brian Chang, Matthew Croson, Lorian Straker, Sean Gart, Carla duration of the PETM Dove, John Gerwin, and Sunghwan Jung Joost Frieling, Henrik H. Svensen, Sverre Planke, Margot J. 12012 Breaking the icosahedra in boron carbide Cramwinckel, Haavard Selnes, and Appy Sluijs Kelvin Y. Xie, Qi An, Takanori Sato, Andrew J. Breen, Simon P. 12065 Approaching a realistic force balance in Ringer, William A. Goddard III, Julie M. Cairney, and Kevin J. Hemker geodynamo simulations Rakesh K. Yadav, Thomas Gastine, Ulrich R. Christensen, Scott J. 12017 Controlling the mode of operation of organic Wolk, and Katja Poppenhaeger transistors through side-chain engineering 12071 Hurricane Sandy’s flood frequency increasing from Alexander Giovannitti, Dan-Tiberiu Sbircea, Sahika Inal, year 1800 to 2100 Christian B. Nielsen, Enrico Bandiello, David A. Hanifi, Michele Sessolo, George G. Malliaras, Iain McCulloch, Ning Lin, Robert E. Kopp, Benjamin P. Horton, and Jeffrey P. Donnelly and Jonathan Rivnay ENGINEERING ASTRONOMY 12076 Controlling uncertainty in aptamer selection 12023 A Population of planetary systems characterized by Fabian Spill, Zohar B. Weinstein, Atena Irani Shemirani, Nga Ho, short-period, Earth-sized planets Darash Desai, and Muhammad H. Zaman Jason H. Steffen and Jeffrey L. Coughlin 12082 Spatiotemporal periodicity of dislocation dynamics in a two-dimensional microfluidic crystal flowing in CHEMISTRY a tapered channel E6555 Rippling ultrafast dynamics of suspended 2D Ya Gai, Chia Min Leong, Wei Cai, and Sindy K. Y. Tang monolayers, graphene 12088 Directional amorphization of boron carbide subjected Jianbo Hu, Giovanni M. Vanacore, Andrea Cepellotti, Nicola to laser shock compression Marzari, and Ahmed H. Zewail Shiteng Zhao, Bimal Kad, Bruce A. Remington, Jerry C. LaSalvia, 12029 Theory of single-molecule controlled rotation Christopher E. Wehrenberg, Kristopher D. Behler, and Marc A. Meyers experiments, predictions, tests, and comparison 12126 Extracellular matrix stiffness causes systematic with stalling experiments in F1-ATPase variations in proliferation and chemosensitivity Sa´ndor Volka´n-Kacso´ and Rudolph A. Marcus in myeloid leukemias

12035 Mechanism of O2 activation and substrate Jae-Won Shin and David J. Mooney hydroxylation in noncoupled binuclear copper monooxygenases PHYSICS Ryan E. Cowley, Li Tian, and Edward I. Solomon 12094 Site-specific colloidal crystal nucleation by 12041 Evidence from mixed hydrate nucleation for a funnel template-enhanced particle transport model of crystallization Chandan K. Mishra, A. K. Sood, and Rajesh Ganapathy Kyle Wm. Hall, Sheelagh Carpendale, and Peter G. Kusalik 12168 Transferable model for chromosome architecture 12047 Molecular insight into the nanoconfined Michele Di Pierro, Bin Zhang, Erez Lieberman Aiden, Peter G. calcite–solution interface Wolynes, and Jose´ N. Onuchic Yijue Diao and Rosa M. Espinosa-Marzal See Commentary on page 11991

iv u www.pnas.org Contents Downloaded by guest on September 24, 2021 12144 Bicarbonate-induced redox tuning in Photosystem II SOCIAL SCIENCES for regulation and protection ANTHROPOLOGY Katharina Brinkert, Sven De Causmaecker, Anja Krieger-Liszkay, Andrea Fantuzzi, and A. William Rutherford 12120 Resource scarcity drives lethal aggression among prehistoric hunter-gatherers in central California 12150 Context-specific inhibition of translation by ribosomal Mark W. Allen, Robert Lawrence Bettinger, Brian F. Codding, antibiotics targeting the peptidyl transferase center Terry L. Jones, and Al W. Schwitalla James Marks, Krishna Kannan, Emily J. Roncase, Dorota Klepacki, Amira Kefi, Ce´dric Orelle, Nora Va´zquez-Laslop, and Alexander S. Mankin ECONOMIC SCIENCES 12099 Expert Game experiment predicts emergence of trust 12156 Recognition of enzymes lacking bound cofactor by in professional communication networks protein quality control Kristian Moss Bendtsen, Florian Uekermann, and Jan O. Haerter Adria´n Martı´nez-Limo´n, Marion Alriquet, Wei-Han Lang, Giulia Calloni, Ilka Wittig, and R. Martin Vabulas

SOCIAL SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY 12105 Moderating attitudes in times of violence through paradoxical thinking intervention E6582 Working stroke of the kinesin-14, ncd, comprises two substeps of different direction Boaz Hameiri, Roni Porat, Daniel Bar-Tal, and Eran Halperin Bert Nitzsche, Elzbieta Dudek, Lukasz Hajdo, Andrzej A. 12111 Reading intervention with a growth mindset approach Kasprzak, Andrej Vilfan, and Stefan Diez improves children’s skills 12029 Theory of single-molecule controlled rotation Simon Calmar Andersen and Helena Skyt Nielsen experiments, predictions, tests, and comparison 12114 Formation of raiding parties for intergroup violence is with stalling experiments in F1-ATPase mediated by social network structure Sa´ndor Volka´n-Kacso´ and Rudolph A. Marcus Luke Glowacki, Alexander Isakov, Richard W. Wrangham, Rose 12076 Controlling uncertainty in aptamer selection McDermott, James H. Fowler, and Nicholas A. Christakis Fabian Spill, Zohar B. Weinstein, Atena Irani Shemirani, Nga Ho, Darash Desai, and Muhammad H. Zaman 12162 Graded activation and free energy landscapes of BIOLOGICAL SCIENCES a muscarinic G-protein–coupled receptor Yinglong Miao and J. Andrew McCammon ANTHROPOLOGY 12168 Transferable model for chromosome architecture 12120 Resource scarcity drives lethal aggression among Michele Di Pierro, Bin Zhang, Erez Lieberman Aiden, Peter G. prehistoric hunter-gatherers in central California Wolynes, and Jose´ N. Onuchic Mark W. Allen, Robert Lawrence Bettinger, Brian F. Codding, See Commentary on page 11991 Terry L. Jones, and Al W. Schwitalla 12174 Structure and assembly model for the Trypanosoma cruzi APPLIED BIOLOGICAL SCIENCES 60S ribosomal subunit 12006 How seabirds plunge-dive without injuries Zheng Liu, Cristina Gutierrez-Vargas, Jia Wei, Robert A. Grassucci, Madhumitha Ramesh, Noel Espina, Ming Sun, Beril Brian Chang, Matthew Croson, Lorian Straker, Sean Gart, Carla Tutuncuoglu, Susan Madison-Antenucci, John L. Woolford Jr., Dove, John Gerwin, and Sunghwan Jung Liang Tong, and Joachim Frank 12126 Extracellular matrix stiffness causes systematic 12180 Inferring interaction partners from protein sequences variations in proliferation and chemosensitivity Anne-Florence Bitbol, Robert S. Dwyer, Lucy J. Colwell, in myeloid leukemias and Ned S. Wingreen Jae-Won Shin and David J. Mooney 12186 Simultaneous identification of specifically interacting paralogs and interprotein contacts by direct BIOCHEMISTRY coupling analysis E6562 Backtracked and paused transcription initiation Thomas Gueudre´, Carlo Baldassi, Marco Zamparo, Martin intermediate of Escherichia coli RNA polymerase Weigt, and Andrea Pagnani Eitan Lerner, SangYoon Chung, Benjamin L. Allen, Shuang Wang, Jookyung Lee, Shijia W. Lu, Logan W. Grimaud, Antonino CELL BIOLOGY Ingargiola, Xavier Michalet, Yazan Alhadid, Sergei Borukhov, Terence R. Strick, Dylan J. Taatjes, and Shimon Weiss E6590 Mitotic Golgi disassembly is required for bipolar spindle formation and mitotic progression E6572 Crystal structure of the DNA binding domain of the Gianni Guizzunti and Joachim Seemann transcription factor T-bet suggests simultaneous recognition of distant genome sites E6600 FOXA1 overexpression mediates endocrine resistance Ce Feng Liu, Gabriel S. Brandt, Quyen Q. Hoang, Natalia by altering the ER transcriptome and IL-8 expression Naumova, Vanja Lazarevic, Eun Sook Hwang, Job Dekker, in ER-positive breast cancer Laurie H. Glimcher, Dagmar Ringe, and Gregory A. Petsko Xiaoyong Fu, Rinath Jeselsohn, Resel Pereira, Emporia F. Hollingsworth, Chad J. Creighton, Fugen Li, Martin Shea, 12132 Terpene synthase genes in eukaryotes beyond plants Agostina Nardone, Carmine De Angelis, Laura M. Heiser, and fungi: Occurrence in social amoebae Pavana Anur, Nicholas Wang, Catherine S. Grasso, Paul T. Xinlu Chen, Tobias G. Ko¨llner, Qidong Jia, Ayla Norris, Balaji Spellman, Obi L. Griffith, Anna Tsimelzon, Carolina Gutierrez, Shixia Santhanam, Patrick Rabe, Jeroen S. Dickschat, Gad Shaulsky, Huang, Dean P. Edwards, Meghana V. Trivedi, Mothaffar F. Rimawi, Jonathan Gershenzon, and Feng Chen Dolores Lopez-Terrada, Susan G. Hilsenbeck, Joe W. Gray, Myles 12138 Radical new paradigm for heme degradation in Brown, C. Kent Osborne, and Rachel Schiff Escherichia coli O157:H7 E6610 V-1 regulates capping protein activity in vivo Joseph W. LaMattina, David B. Nix, and William Goeh Jung, Christopher J. Alexander, Xufeng S. Wu, Grzegorz Nicholas Lanzilotta Piszczek, Bi-Chang Chen, Eric Betzig, and John A. Hammer

Contents PNAS u October 25, 2016 u vol. 113 u no. 43 u v Downloaded by guest on September 24, 2021 12192 Single cell lineage tracing reveals a role for TgfβR2 in E6659 miRNA92a targets KLF2 and the phosphatase PTEN intestinal stem cell dynamics and differentiation signaling to promote human T follicular helper Jared M. Fischer, Peter P. Calabrese, Ashleigh J. Miller, Nina M. precursors in T1D islet autoimmunity Mun˜oz, William M. Grady, Darryl Shibata, and R. Michael Liskay Isabelle Serr, Rainer W. Fu¨rst, Verena B. Ott, Martin G. Scherm, 12198 Human mitochondrial ribosomes can switch their Alexei Nikolaev, Fu¨sun Go¨kmen, Stefanie Ka¨lin, Stephanie structural RNA composition Zillmer, Melanie Bunk, Benno Weigmann, Nicole Kunschke, Brigitta Loretz, Claus-Michael Lehr, Benedikt Kirchner, Bettina Joanna Rorbach, Fei Gao, Christopher A. Powell, Aaron Haase, Michael Pfaffl, Ari Waisman, Richard A. Willis, Anette-G. D’Souza, Robert N. Lightowlers, Michal Minczuk, Ziegler, and Carolin Daniel and Zofia M. Chrzanowska-Lightowlers 12232 Maresin conjugates in tissue regeneration biosynthesis DEVELOPMENTAL BIOLOGY enzymes in human macrophages Jesmond Dalli, Iliyan Vlasakov, Ian R. Riley, Ana R. 12202 Retinol and ascorbate drive erasure of epigenetic Rodriguez, Bernd W. Spur, Nicos A. Petasis, Nan Chiang, memory and enhance reprogramming to naïve and Charles N. Serhan pluripotency by complementary mechanisms Timothy Alexander Hore, Ferdinand von Meyenn, Mirunalini Ravichandran, Martin Bachman, Gabriella Ficz, David Oxley, MEDICAL SCIENCES Fa´tima Santos, Shankar Balasubramanian, Tomasz P. Jurkowski, E6669 ATM/G6PD-driven redox metabolism promotes FLT3 and Wolf Reik inhibitor resistance in acute myeloid leukemia Mark A. Gregory, Angelo D’Alessandro, Francesca ENVIRONMENTAL SCIENCES Alvarez-Calderon, Jihye Kim, Travis Nemkov, Biniam Adane, 12208 Cryptophyte farming by symbiotic ciliate host Andrii I. Rozhok, Amit Kumar, Vijay Kumar, Daniel A. Pollyea, detected in situ Michael F. Wempe, Craig T. Jordan, Natalie J. Serkova, Aik Choon Tan, Kirk C. Hansen, and James DeGregori Dajun Qiu, Liangmin Huang, and Senjie Lin 12238 Mutational landscape of uterine and ovarian EVOLUTION carcinosarcomas implicates histone genes in epithelial–mesenchymal transition 12214 Gene transfers from diverse bacteria compensate for Siming Zhao, Stefania Bellone, Salvatore Lopez, Durga reductive genome evolution in the chromatophore Paulinella chromatophora Thakral, Carlton Schwab, Diana P. English, Jonathan Black, of Emiliano Cocco, Jungmin Choi, Luca Zammataro, Federica Eva C. M. Nowack, Dana C. Price, Debashish Bhattacharya, Anna Predolini, Elena Bonazzoli, Mark Bi, Natalia Buza, Pei Hui, Singer, Michael Melkonian, and Arthur R. Grossman Serena Wong, Maysa Abu-Khalaf, Antonella Ravaggi, Eliana Bignotti, Elisabetta Bandiera, Chiara Romani, Paola GENETICS Todeschini, Renata Tassi, Laura Zanotti, Franco Odicino, E6620 Genetic architecture of natural variation in visual Sergio Pecorelli, Carla Donzelli, Laura Ardighieri, Fabio Drosophila Facchetti, Marcella Falchetti, Dan-Arin Silasi, Elena Ratner, senescence in Masoud Azodi, Peter E. Schwartz, Shrikant Mane, Roberto Mary Anna Carbone, Akihiko Yamamoto, Wen Huang, Rachel A. Angioli, Corrado Terranova, Charles Matthew Quick, Babak Lyman, Tess Brune Meadors, Ryoan Yamamoto, Robert R. H. Edraki, Kaya Bilgu¨var, Moses Lee, Murim Choi, Amy L. Anholt, and Trudy F. C. Mackay Stiegler, Titus J. Boggon, Joseph Schlessinger, Richard P. 12220 Differential roles of the RNases H in preventing Lifton, and Alessandro D. Santin chromosome instability 12244 Data-driven identification of prognostic tumor Anjali D. Zimmer and Douglas Koshland subpopulations using spatially mapped t-SNE 12226 Germline replications and somatic mutation accumulation of mass spectrometry imaging data are independent of vegetative life span Walid M. Abdelmoula, Benjamin Balluff, Sonja Englert, Jouke in Arabidopsis Dijkstra, Marcel J. T. Reinders, Axel Walch, Liam A. McDonnell, J. Matthew Watson, Alexander Platzer, Anita Kazda, Svetlana and Boudewijn P. F. Lelieveldt Akimcheva, Sona Valuchova, Viktoria Nizhynska, Magnus 12250 Notch3 drives development and progression Nordborg, and Karel Riha of cholangiocarcinoma Rachel V. Guest, Luke Boulter, Benjamin J. Dwyer, Timothy J. IMMUNOLOGY AND INFLAMMATION Kendall, Tak-Yung Man, Sarah E. Minnis-Lyons, Wei-Yu Lu, E6630 Architecture of a minimal signaling pathway explains Andrew J. Robson, Sofia Ferreira Gonzalez, Alexander Raven, the T-cell response to a 1 million-fold variation in Davina Wojtacha, Jennifer P. Morton, Mina Komuta, Tania Roskams, Stephen J. Wigmore, Owen J. Sansom, antigen affinity and dose and Stuart J. Forbes Melissa Lever, Hong-Sheng Lim, Philipp Kruger, John Nguyen, Nicola Trendel, Enas Abu-Shah, Philip Kumar Maini, Philip Anton van der Merwe, and Omer Dushek MICROBIOLOGY E6639 Sustained antigen availability during germinal center 11998 Tilting the balance between RNA interference and initiation enhances antibody responses to vaccination replication eradicates Leishmania RNA virus 1 Hok Hei Tam, Mariane B. Melo, Myungsun Kang, Jeisa M. Pelet, and mitigates the inflammatory response Vera M. Ruda, Maria H. Foley, Joyce K. Hu, Sudha Kumari, Erin A. Brettmann, Jahangheer S. Shaik, Haroun Zangger, Jordan Crampton, Alexis D. Baldeon, Rogier W. Sanders, Lon-Fye Lye, F. Matthew Kuhlmann, Natalia S. Akopyants, John P. Moore, Shane Crotty, Robert Langer, Daniel G. Dayna M. Oschwald, Katherine L. Owens, Suzanne M. Anderson, Arup K. Chakraborty, and Darrell J. Irvine Hickerson, Catherine Ronet, Nicolas Fasel, E6649 A conserved αβ transmembrane interface forms the and Stephen M. Beverley core of a compact T-cell receptor–CD3 structure 12256 Herpes simplex virus ICP27 regulates alternative within the membrane pre-mRNA polyadenylation and splicing in a Logesvaran Krshnan, Soohyung Park, Wonpil Im, Melissa J. Call, sequence-dependent manner and Matthew E. Call Shuang Tang, Amita Patel, and Philip R. Krause

vi u www.pnas.org Contents Downloaded by guest on September 24, 2021 12262 Proteolytic processing of Middle East respiratory 12310 Physical interaction between neurofibromin and syndrome coronavirus spikes expands serotonin 5-HT6 receptor promotes receptor virus tropism constitutive activity Jung-Eun Park, Kun Li, Arlene Barlan, Anthony R. Fehr, Stanley Wissem Deraredj Nadim, Se´verine Chaumont-Dubel, Fahima Perlman, Paul B. McCray Jr., and Tom Gallagher Madouri, Laetitia Cobret, Marie-Ludivine De Tauzia, Pawel Zajdel, 12268 Assembly and transfer of tripartite integrative and He´le`ne Be´ne´detti, Philippe Marin, and Se´verine Morisset-Lopez conjugative genetic elements Timothy L. Haskett, Jason J. Terpolilli, Amanuel Bekuma, PLANT BIOLOGY Graham W. O’Hara, John T. Sullivan, Penghao Wang, E6704 Role of DNA methylation in hybrid vigor in Clive W. Ronson, and Joshua P. Ramsay Arabidopsis thaliana Takahiro Kawanabe, Sonoko Ishikura, Naomi Miyaji, NEUROSCIENCE Taku Sasaki, Li Min Wu, Etsuko Itabashi, Satoko Takada, E6679 Fast fMRI can detect oscillatory neural activity Motoki Shimizu, Takeshi Takasaki-Yasuda, Kenji Osabe, W. James Peacock, Elizabeth S. Dennis, and Ryo Fujimoto in humans Laura D. Lewis, Kawin Setsompop, Bruce R. Rosen, 12316 Nascent RNA sequencing reveals distinct features in and Jonathan R. Polimeni plant transcription E6686 Orthopedic surgery modulates neuropeptides Jonathan Hetzel, Sascha H. Duttke, Christopher Benner, and Joanne Chory and BDNF expression at the spinal and hippocampal levels 12322 Flavodiiron proteins act as safety valve for electrons in Physcomitrella patens Ming-Dong Zhang, Swapnali Barde, Ting Yang, Beilei Lei, Lars I. Eriksson, Joseph P. Mathew, Thomas Andreska, Katerina Caterina Gerotto, Alessandro Alboresi, Andrea Meneghesso, Akassoglou, Tibor Harkany, Tomas G. M. Ho¨kfelt, Martina Jokel, Marjaana Suorsa, Eva-Mari Aro, and Niccolo` Terrando and Tomas Morosinotto 12274 Overdrinking, swallowing inhibition, and regional 12328 Microbial-type terpene synthase genes occur widely in brain responses prior to swallowing nonseed land plants, but not in seed plants Pascal Saker, Michael J. Farrell, Gary F. Egan, Michael J. Qidong Jia, Guanglin Li, Tobias G. Ko¨llner, Jianyu Fu, Xinlu McKinley, and Derek A. Denton Chen, Wangdan Xiong, Barbara J. Crandall-Stotler, John L. Bowman, David J. Weston, Yong Zhang, Li Chen, Yinlong Xie, 12280 Identification of the SNARE complex mediating the Fay-Wei Li, Carl J. Rothfels, Anders Larsson, Sean W. Graham, exocytosis of NMDA receptors Dennis W. Stevenson, Gane Ka-Shu Wong, Jonathan Yi Gu and Richard L. Huganir Gershenzon, and Feng Chen 12286 Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats PSYCHOLOGICAL AND COGNITIVE SCIENCES Jessica A. Ash, Hanbing Lu, Lisa R. Taxier, Jeffrey M. Long, Yihong Yang, Elliot A. Stein, and Peter R. Rapp E6712 Human attention filters for single colors Peng Sun, Charles Chubb, Charles E. Wright, and George Sperling 12292 PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model CORRECTIONS (ONLINE ONLY) Loukia Katsouri, Yau M. Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Amy M. Birch, Nazanin BIOCHEMISTRY Mirzaei, Elaine E. Irvine, Nicholas D. Mazarakis, E6721 Molecular architecture of the Spire–actin nucleus and and Magdalena Sastre its implication for actin filament assembly 12298 Central role for melanocortin-4 receptors in Tomasz Sitar, Julia Gallinger, Anna M. Ducka, Teemu P. offspring hypertension arising from Ikonen, Michael Wohlhoefler, Kurt M. Schmoller, Andreas R. maternal obesity Bausch, Peteranne Joel, Kathleen M. Trybus, Angelika A. Anne-Maj S. Samuelsson, Amandine Mullier, Nuria Noegel, Michael Schleicher, Robert Huber, and Tad A. Holak Maicas, Nynke R. Oosterhuis, Sung Eun Bae, Tatiana V. Novoselova, Li F. Chan, Joaquim M. Pombo, Paul D. IMMUNOLOGY Taylor, Jaap A. Joles, Clive W. Coen, Nina Balthasar, E6722 Structural basis of the C1q/C1s interaction and its and Lucilla Poston central role in assembly of the C1 complex of 12304 Essential protective role of tumor necrosis factor complement activation receptor 2 in neurodegeneration Umakhanth Venkatraman Girija, Alexandre R. Gingras, Jamie E. Yun Dong, Roman Fischer, Petrus J. W. Naude´, Olaf Marshall, Roshni Panchal, Md. Arif Sheikh, Pe´ter Ga´l, Maier, Csaba Nyakas, Mae¨lle Duffey, Eddy A. Van der Zee, Wilhelm J. Schwaeble, Daniel A. Mitchell, Peter C. E. Moody, Doortje Dekens, Wanda Douwenga, Andreas Herrmann, and Russell Wallis Eric Guenzi, Roland E. Kontermann, Klaus Pfizenmaier, and Ulrich L. M. Eisel NEUROSCIENCE E6723 Individual variability in functional connectivity PHARMACOLOGY predicts performance of a perceptual task E6696 Allosteric binding site in a Cys-loop receptor ligand- Antonello Baldassarre, Christopher M. Lewis, Giorgia binding domain unveiled in the crystal structure of Committeri, Abraham Z. Snyder, Gian Luca Romani, ELIC in complex with chlorpromazine and Maurizio Corbetta Mieke Nys, Eveline Wijckmans, Ana Farinha, O¨ zge Yoluk, Magnus Andersson, Marijke Brams, Radovan Spurny, Steve Peigneur, Jan Tytgat, Erik Lindahl, and Chris Ulens ix Subscription Form

Contents PNAS u October 25, 2016 u vol. 113 u no. 43 u vii Downloaded by guest on September 24, 2021