In conjunction with the Global Young Scientists Summit@one-north (GYSS@one-north) 2014, NUS is hosting a panel discussion on “Science and Society”. We are privileged to have 3 eminent scientists on the panel and Prof Barry Halliwell, Deputy President (Research and Technology) will be the moderator for this panel discussion.

Date Monday, 20 January 2014 Time 6:30pm (Light refreshments will be served from 6pm) Lecture Theatre 35 Level 1, MD6, Centre for Translational Medicine Venue National University of Singapore

14 Medical Drive Singapore 117599

3 Eminent scientists on the panel:

Prof Hartmut Michel Prof Stephen Smale Dr John Robin Warren

A biochemist by training, Prof Michel One of the best known American Dr Warren is an Australian pathologist received the 1988 Nobel Prize in mathematicians, Prof Smale was who is credited, together with Barry Chemistry for unravelling how a awarded the Fields Medal in 1966 for Marshall, with the 1979 re-discovery of membrane-bound protein active in his work on topology in higher the bacterium Helicobacter pylori, photosynthesis is built up. dimensions. which they proved is the cause of stomach ulcers. In 2005, he was awarded the Nobel Prize in Medicine.

Refer to annex for the profiles of the eminent panelists and panel moderator.

This panel discussion is open to the public and admission is free. Registration is requested at www.pdsns.eventbrite.sg for catering purposes.

Sir Andre Geim Regius and Royal Society Research Professor The University of Manchester Nobel Prize in Physics (2010) ------

------Sir Andre Geim is the Regius and Royal Society Research Professor at the University of Manchester. He was awarded the 2010 Nobel Prize for his groundbreaking work on graphene, a one-atom-thick material made of carbon. He has also received numerous international awards and distinctions, including medals from the US National Academy of Sciences and the UK Royal Society, and holds honorary doctorates and professorships from many countries.

Andre Geim was born in Russia to German parents and holds dual Dutch and British citizenship. He started his academic career in Moscow, spent several years as a postdoctoral researcher at the universities of Nottingham, Bath and Copenhagen and then moved to the Netherlands as a tenured professor, before coming to Manchester in 2001.

Thomson-Reuters repeatedly named him among the world’s most active scientists and attributed to him three new research fronts – diamagnetic levitation, gecko tape and graphene. He was also awarded the IgNobel prize in 2000 for his work on levitation, becoming the first and only recipient of both Nobel and IgNobel Prizes. He has also received both Dutch and British knighthoods.

*Extracted from http://www.condmat.physics.manchester.ac.uk/people/academic/geim/ Hartmut Michel Director, Max Planck Institute of Biophysics & Adjunct Professor University of Frankfurt, Germany Nobel Prize in Chemistry (1988)

German biochemists Hartmut Michel, Robert Huber, and Johann Deisenhofer received the 1988 chemistry award for unravelling how a membrane-bound protein active in photosynthesis is built up. At the time the trio all worked at the Max-Planck Institute in Munich. Plants use the energy of light to build orgai atter, reatig the ost asi foodstuff i the world’s food hai - vegetation. Furthermore, the plants produce oxygen, which allows bodies to burn the organic matter. Photosynthesis, says the official Nobel press release of the 1988 chemistry award, is "the most important chemical reaction on earth". The conversion of energy in photosynthesis and cellular respiration takes place through the transport of electrons via a series of proteins, which are bound in special membranes. These proteins are difficult to obtain in a crystalline form, but in 1981 Michel succeeded, allowing him, with Deisenhofer and Huber, to study their structure.

Michel was born in Ludwigsburg, Germany, in 1948. He was an active, outdoors child and a good pupil and joined a circulating library, reading several educational books per week. After military service he entered the University of Tübingen in 1969 to study biochemistry, graduating in 1974, and working under Dieter Oesterhelt at the Max-Planck-Gesellschaft in Tübingen and the University of Würzburg, where he gained his PhD in 1977. While exploring ways to produce light-driven amino acid uptake Michel found that a sample of delipidatedbacteriorhodopsin yielded solid, glass-like aggregates when stored in a freezer. Thus he was convinced that it should be possible to crystallise membrane proteins, whih was osidered ipossile at the tie. With Oesterhelt’s help Michel soon produced a two- dimensional membrane crystal of bacteriorhodopsin, and the first real three-dimensional crystals in April 1979. The pair joined the Max-Planck-InstitutfürBiochemie near Munich, where Michel worked with Hans Deisenhofer, a member of Robert Huber's department, an expert in X-ray crystallographic protein structure analysis.

He also spent four months at the Medical Research Council in Cambridge, England, performing X-ray experiments and improving the crystallisation method. Back at Munich Michel crystallised several other membrane proteins, mainly photosynthetic ones, gaining his first success with the reaction centre from the purple bacterium Rhodopseudomonasviridis in 1981. The following year Michel was joined by Johann (Hans) Deisenhofer in the reaction centre project, and the pair became fast friends and colleagues. In 1987 Michel became a department head and director at the Max-Planck- InstitutfürBiophysik in Frankfurt am Main.

He has received various prizes and awards, several with Deisenhofer and Huber. Michel is married to Elena Olkhova.

Stephen Smale Fields Medal (1966)

Stephen Smale (born July 15, 1930) is an American mathematician from Flint, Michigan. He was awarded the Fields Medal in 1966, and spent more than three decades on the mathematics faculty of the University of California, Berkeley (1960-61 and 1964-1995).

Education and career

Smale entered the University of Michigan in 1948. Initially, he was a good student, placing into an honors calculus sequence taught by Bob Thrall and earning himself A's. However, his sophomore and junior years were marred with mediocre grades, mostly Bs, Cs and even an F in nuclear physics. However, with some luck, Smale was accepted as a graduate student at the University of Michigan's mathematics department. Yet again, Smale performed poorly his first years, earning a C average as a graduate student. It was only when the department chair, Hildebrandt, threatened to kick out Smale, that he began to work hard. Smale finally earned his Ph.D. in 1957, under Raoul Bott.

Smale began his career as an instructor at the college at the University of Chicago. In 1958, he astounded the mathematical world with a proof of asphere eversion. He then cemented his reputation with a proof of the Poincaré conjecture for all dimensions greater than or equal to 5, published in 1961; in 1962 he generalized the ideas in a 107 page paper that established the h-cobordism theorem.

After having made great strides in topology, he then turned to the study of dynamical systems, where he made significant advances as well. His first contribution is the Smale horseshoe that jumpstarted significant research in dynamical systems. He also outlined a research program carried out by many others. Smale is also known for injecting Morse theory into mathematical economics, as well as recent explorations of various theories of computation.

In 1998 he compiled a list of 18 problems in mathematics to be solved in the 21st century, known as Smale's problems. This list was compiled in the spirit of Hilbert's famous list of problems produced in 1900. In fact, Smale's list contains some of the original Hilbert problems, including theRiemann hypothesis and the second half of Hilbert's sixteenth problem, both of which are still unsolved. Other famous problems on his list include the Poincaré conjecture, the P = NP problem, and the Navier–Stokes equations, all of which have been designated Millennium Prize Problems by the Clay Mathematics Institute.

Earlier in his career, Smale was involved in controversy over remarks he made regarding his work habits while proving the higher dimensional Poincaré conjecture. He said that his best work had been done "on the beaches of Rio". This led to the withholding of his grant money from theNSF. He has been politically active in various movements in the past, such as the Free Speech movement. At one time he was subpoenaed by theHouse Un-American Activities Committee.

In 1960 Smale was appointed an associate professor of mathematics at the University of California, Berkeley, moving to a professorship atColumbia University the following year. In 1964 he returned to a professorship at UC Berkeley where he has spent the main part of his career. He retired from UC Berkeley in 1995 and took up a post as professor at the City University of Hong Kong. He also amassed over the years one of the finest private mineral collections in existence. Many of Smale's mineral specimens can be seen in the book - The Smale Collection: Beauty in Natural Crystals.

Since 2002 Smale is a Professor at the Toyota Technological Institute at Chicago; starting August 1, 2009, he is also a Distinguished University Professor at the City University of Hong Kong.[4]

In 2007, Smale was awarded the Wolf Prize in mathematics. John Robin Warren Physiology or Medicine (2005)

Dr. Warren was born in 1937, in Adelaide, South Australia. He graduated M.B., B.S. from the University of Adelaide in 1961. After training at the Royal Melbourne Hospital, he was admitted to the Royal College of Pathologists of Australasia in 1967. Since then, he was a senior consultant pathologist at the Royal Perth Hospital in Western Australia, becoming emeritus consultant pathologist in 1998.

In 1979, Dr. Warren first observed the presence of small curved bacteria, resembling Campylobacter, on a biopsy of the gastric mucosa. During the next two years, Dr Warren found many more examples of the bacteria on gastric biopsies, always on gastric-type epithelium and closely linked to a specific variety of gastritis.

In 1981, Dr. Warren met Dr. Barry Marshall, registrar in the gastroenterology department. A fruitful partnership followed that demonstrated the clinical significance of the bacteria. They cultured the organisms and identified a new species, now called Helicobacter pylori. A clear association was found between H. pylori and peptic ulcers. Healed ulcers remained healed, without further medication after eradicating the bacteria.

Professor Barry Halliwell Deputy President (Research and Technology) and Tan Chin Tuan Centennial Professor ------

------Professor Barry Halliwell is Deputy President (Research and Technology) at the National University of Singapore and is responsible for driving the University's research agenda He is involved in planning and establishing research institutes, centers and programs as well as in helping to formulate policies and agreements relating to intellectual property rights. He oversees the NUS research institutes and centres, the NUS Institutional Review Board (IRB) and NUS Institutional Animal Care & Use Committee (IACUC) and enforcement of the NUS Research Integrity Code. His responsibilities also include overseeing the expansion and allocation of research funding and liaison with granting bodies.

Professor Halliwell graduated from the University of Oxford with BA (1st class) and D.Phil degrees. He holds a D.Sc degree from the University of London. He was a faculty member with the University of London, King’s College from 1974 to 2000 and held a prestigious Lister Institute Research fellowship. From 1995 to 1999, he was a Visiting Research Professor of Internal Medicine and Biochemistry with the University of California, School of Medicine, Divisions of Cardiology and Pulmonary/Critical Care Medicine. Professor Halliwell was a Visiting Professor of Biochemistry to NUS from 1998 to 2000. He was Head of the University’s Department of Biochemistry from 2003 to 2007 and was Deputy Director, Office of Life Sciences from 2001 to 2005. From 2003 to September 2008, he was Executive Director of the NUS Graduate School of Integrative Sciences and Engineering.

An internationally-acclaimed biochemist, Professor Halliwell is known especially for his seminal work on the role of free radicals and antioxidants in biological systems. The Thomson Reuters lists Professor Halliwell as one of the world’s most highly-cited researchers in Neurobiology & Behaviour, Pharmacology & Toxicology, Biology and Biochemistry and his Hirsch Index is 136. http://www.researcherid.com/rid/C-8318-2009 His book Free Radicals in Biology and Medicine published by Oxford University Press, and now in its fourth edition, is regarded worldwide as an authoritative text in the field. He was awarded the “Lifetime Achievement Award” by the Society for Free Radical Biology and Medicine in the USA for overall sustained excellence in the field. He was recently awarded the Ken Bowman Research Award for outstanding achievements in the field of cardiovascular research from the Institute of Cardiovascular Sciences (Canada) and NUS University Award – Outstanding Researcher Award. His laboratory is also ranked number one worldwide by highest citation score in Free Radical Research.

His research focuses on the role of free radicals and antioxidants in human disease, particularly Alzheimer’s disease and other brain disorders, such as strokes, and in the ageing process. His interest in identifying the most important antioxidants in the human diet and in developing novel antioxidants has critical bearing on treating human diseases and understanding how diet might cause or prevent them.

Professor Halliwell is a member of several editorial boards including FEBS Letters, Biochemical Journal and Antioxidants and Redox Signaling. He has been a lead speaker at Gordon Conferences and other prestigious events worldwide and is a member of several expert advisory panels to leading universities, companies and government agencies.

*Extracted from http://nus.edu.sg/about-nus/nus-structure/management/item/3-professor-barry-halliwell NUS - National University of Singapore Page 1 of 2

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