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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Fotonica Ed Elettronica Quantistica
Fotonica ed elettronica quantistica http://www.dsf.unica.it/~fotonica/teaching/fotonica.html Fotonica ed elettronica quantistica Quantum optics - Quantization of electromagnetic field - Statistics of light, photon counting and noise; - HBT and correlation; g1 e g2 coherence; antibunching; single photons - Squeezing - Quantum cryptography - Quantum computer, entanglement and teleportation Light-matter Interaction - Two-level atom - Laser physics - Spectroscopy - Electronics and photonics at the nanometer scale - Cold atoms - Photodetectors - Solar cells http://www.dsf.unica.it/~fotonica/teaching/fotonica.html Energy Temperature LHC at CERN, Higgs, SUSY, ??? TeV 15 q q particle accelerators 10 K q GeV proton rest mass - quarks 1012K MeV electron rest mass / gamma rays 109K keV Nuclear Fusion, x rays, Sun center 106K Atoms ionize - visible light eV Sun surface fundamental components components fundamental room temperature 103K meV Liquid He, superconductors, space 1K dilution refrigerators, quantum Hall µeV laser-cooled atoms 10-3K neV Bose-Einstein condensates 10-6K peV low T record 480 picokelvin 10-9K -12 complexity, organization organization complexity, 10 K Nobel Prizes in Physics 2010 - Andre Geims, Konstantin Novoselov 2009 - Charles K. Kao, Willard S. Boyle, George E. Smith 2007 - Albert Fert, Peter Gruenberg 2005 - Roy J. Glauber, John L. Hall, Theodor W. Hänsch 2001 - Eric A. Cornell, Wolfgang Ketterle, Carl E. Wieman 1997 - Steven Chu, Claude Cohen-Tannoudji, William D. Phillips 1989 - Norman F. Ramsey, Hans G. Dehmelt, Wolfgang Paul 1981 - Nicolaas Bloembergen, Arthur L. Schawlow, Kai M. Siegbahn 1966 - Alfred Kastler 1964 - Charles H. Townes, Nicolay G. Basov, Aleksandr M. Prokhorov 1944 - Isidor Isaac Rabi 1930 - Venkata Raman 1921 - Albert Einstein 1907 - Albert A. -
Laboratoire Kastler Brossel, LKB, ENS PARIS, Sorbonne Université, COLL DE FRANCE, CNRS, Mr Antoine HEIDMANN
Research evaluation REPORT ON THE RESEARCH UNIT: Kastler Brossel Laboratory LKB UNDER THE SUPERVISION OF THE FOLLOWING INSTITUTIONS AND RESEARCH BODIES: École Normale Supérieure Sorbonne Université Collège de France Centre National de la Recherche Scientifique - CNRS EVALUATION CAMPAIGN 2017-2018 GROUP D In the name of Hcéres1 : In the name of the expert committee2 : Michel Cosnard, President Vahid Sandoghdar, Chairman of the committee Under the decree No.2014-1365 dated 14 November 2014, 1 The president of HCERES "countersigns the evaluation reports set up by the expert committees and signed by their chairman." (Article 8, paragraph 5); 2 The evaluation reports "are signed by the chairman of the expert committee". (Article 11, paragraph 2). Laboratoire Kastler Brossel, LKB, ENS PARIS, Sorbonne Université, COLL DE FRANCE, CNRS, Mr Antoine HEIDMANN This report is the sole result of the unit’s evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee. UNIT PRESENTATION Unit name: Laboratoire Kastler-Brossel Unit acronym: LKB Requested label: UMR Application type: Renewal Current number: UMR 8552 Head of the unit Mr Antoine HEIDMANN (2017-2018): Project leader Mr Antoine HEIDMANN (2019-2023): Number of teams: 12 COMMITTEE MEMBERS Chair: Mr Vahid SANDOGHDAR, Max Planck Institute, Germany Experts: Mr Jean-Claude BERNARD, CNRS (supporting personnel) Mr Benoît BOULANGER, Université Grenoble Alpes (representative -
Unesco High Panel on Science for Development
UNESCO HIGH PANEL ON SCIENCE AND TECHNOLOGY FOR DEVELOPMENT ** Attendees 15-16 September 2011 **Dr Atta-ur-Rahman President, Network of Academies of Science of Islamic Countries Distinguished National Professor of Chemistry, Karachi University Karachi, Pakistan **Dr Susan Avery President and Director, Woods Hole Oceanographic Institution Woods Hole, MA, USA **Dr Vijay Chandru Chief Executive Officer, Strand Life Sciences Bangalore, India Sir Partha Dasgupta Frank Ramsey Professor of Economics, University of Cambridge Cambridge, UK HRH Princess Sumaya bint El Hassan of Jordan President of the Royal Scientific Society Hashemite Kingdom of Jordan **HRH exceptionally to be replaced by Prof. Odeh Al-Jayyousi Vice-President of the Royal Scientific Society Hashemite Kingdom of Jordan Dr Rolf Heuer Director-General, CERN Geneva, Switzerland **Dr Sergei Kapitza Vice President, Academy of Natural Sciences, Russia Professor, Institute of Physics Moscow, Russia Dr Gong Ke President, Nankai University Tianjin, China **Prof. Dr Javier de Lucas Director, Cité internationale universitaire de Paris Paris, France **Prof. Dr Wolfram Mauser Dean of the Faculty of Geosciences Munich Ludwig Maximilian University 1 Munich, Germany **Prof. Gordon McBean Department of Geography, Social Science Centre The University of Western Ontario London, ON, Canada **Prof. Ahmadou Lamine N’Diaye President, African Academy of Sciences & President, National Academy of Science and Technology of Senegal Dakar, Senegal Prof. Tebello Nyokong Department of Chemistry Rhodes University -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
AHMED H. ZEWAIL 26 February 1946 . 2 August 2016
AHMED H. ZEWAIL 26 february 1946 . 2 august 2016 PROCEEDINGS OF THE AMERICAN PHILOSOPHICAL SOCIETY VOL. 162, NO. 2, JUNE 2018 biographical memoirs t is often proclaimed that a stylist is someone who does and says things in memorable ways. From an analysis of his experimental Iprowess, his written contributions, his lectures, and even from the details of the illustrations he used in his published papers or during his lectures to scientific and other audiences, Ahmed Zewail, by this or any other definition, was a stylist par excellence. For more than a quarter of a century, I interacted with Ahmed (and members of his family) very regularly. Sometimes he and I spoke several times a week during long-distance calls. Despite our totally different backgrounds we became the strongest of friends, and we got on with one another like the proverbial house on fire. We collaborated scientifi- cally and we adjudicated one another’s work, as well as that of others. We frequently exchanged culturally interesting stories. We each relished the challenge of delivering popular lectures. In common with very many others, I deem him to be unforgettable, for a variety of different reasons. He was one of the intellectually ablest persons that I have ever met. He possessed elemental energy. He executed a succession of brilliant experiments. And, almost single-handedly, he created the subject of femtochemistry, with all its magnificent manifestations and ramifications. From the time we first began to exchange ideas, I felt a growing affinity for his personality and attitude. This was reinforced when I told him that, ever since I was a teenager, I had developed a deep interest in Egyptology and a love for modern Egypt. -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
Antony Hewish
PULSARS AND HIGH DENSITY PHYSICS Nobel Lecture, December 12, 1974 by A NTONY H E W I S H University of Cambridge, Cavendish Laboratory, Cambridge, England D ISCOVERY OF P U L S A R S The trail which ultimately led to the first pulsar began in 1948 when I joined Ryle’s small research team and became interested in the general problem of the propagation of radiation through irregular transparent media. We are all familiar with the twinkling of visible stars and my task was to understand why radio stars also twinkled. I was fortunate to have been taught by Ratcliffe, who first showed me the power of Fourier techniques in dealing with such diffraction phenomena. By a modest extension of existing theory I was able to show that our radio stars twinkled because of plasma clouds in the ionosphere at heights around 300 km, and I was also able to measure the speed of ionospheric winds in this region (1) . My fascination in using extra-terrestrial radio sources for studying the intervening plasma next brought me to the solar corona. From observations of the angular scattering of radiation passing through the corona, using simple radio interferometers, I was eventually able to trace the solar atmo- sphere out to one half the radius of the Earth’s orbit (2). In my notebook for 1954 there is a comment that, if radio sources were of small enough angular size, they would illuminate the solar atmosphere with sufficient coherence to produce interference patterns at the Earth which would be detectable as a very rapid fluctuation of intensity. -
The Nobel Prize in Chemistry 2013 the Royal Swedish Academy of Sciences Has Decided to Award the Nobel Prize in Chemistry for 2013 To
PRESSMEDDELANDE Press release 9 October 2013 The Nobel Prize in Chemistry 2013 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2013 to Martin Karplus Michael Levitt Arieh Warshel Université de Strasbourg, France and Stanford University School of Medicine, University of Southern California, Harvard University, Cambridge, MA, USA Stanford, CA, USA Los Angeles, CA, USA “for the development of multiscale models for complex chemical systems” The computer — your Virgil in the world of atoms Chemists used to create models of molecules This year’s Nobel Laureates in chemistry took the best using plastic balls and sticks. Today, the modelling from both worlds and devised methods that use both is carried out in computers. In the 1970s, Martin classical and quantum physics. For instance, in simu- Karplus, Michael Levitt and Arieh Warshel laid the lations of how a drug couples to its target protein in foundation for the powerful programs that are used the body, the computer performs quantum theoretical to understand and predict chemical processes. calculations on those atoms in the target protein that Computer models mirroring real life have become interact with the drug. The rest of the large protein is crucial for most advances made in chemistry today. simulated using less demanding classical physics. Chemical reactions occur at lightning speed. In a fraction Today the computer is just as important a tool for of a millisecond, electrons jump from one atomic nucleus chemists as the test tube. Simulations are so realistic to the other. Classical chemistry has a hard time keeping that they predict the outcome of traditional experiments. -
Dear Colleague, This Invitation Is Being Sent on Behalf of Prof
Dear colleague, On behalf of Prof. Fernand Marquis (San Diego State U., USA), Prof. Soteris Kalogirou (Cyprus U. of Technology, Cyprus), and Prof. Bernard Raveau (U. of Caen, France), co-chairs of the 2nd International Symposium on Solid State Chemistry for Applications and Sustainable Development in my capacity as President of SIPS 2020/2021, I am personally inviting you to participate as an author/speaker. This major symposium focuses on solid-state chemistry corresponds to the relationships occurring between the synthesis, structure, and physical-chemical properties of solid inorganic compounds (in most cases), leading to a final compound with optimized properties such as advances in the synthesis routes, design of materials for sustainable energy production, advanced characterization techniques and applications, etc. These and many others are among the topics of the symposium. This symposium will be held as part of the combined SIPS 2020/2021, an annual multidisciplinary summit, organized by the not-for-profit corporation FLOGEN Stars Outreach (www.flogen.org), which is dedicated to achieving sustainability through science and technology applied in various fields. It incorporates summit plenary lectures from well-known speakers that address the link between various domains in the pursuit of sustainable development, as well as specific scientific symposia featuring specialized presentations in a specific domain, with the same goals in mind. The symposium and overall summit are planned to be held in Phuket, Thailand from November 28th – December 2nd 2021. We have confirmed until now the participation of the following 9 Nobel Laureates: Prof. Dan Shechtman, Prof. Didier Queloz, Prof. M. Stanley Whittingham, Sir Konstantin Novoselov, Prof. -
Tomaso A. Poggio
BK-SFN-NEUROSCIENCE-131211-09_Poggio.indd 362 16/04/14 5:25 PM Tomaso A. Poggio BORN: Genova, Italy September 11, 1947 EDUCATION: University of Genoa, PhD in Physics, Summa cum laude (1971) APPOINTMENTS: Wissenschaftlicher Assistant, Max Planck Institut für Biologische Kybernetik, Tubingen, Germany (1978) Associate Professor (with tenure), Department of Psychology and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (1981) Uncas and Helen Whitaker Chair, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology (1988) Eugene McDermott Professor, Department of Brain and Cognitive Sciences, Computer Science and Artificial Intelligence Laboratory and McGovern Institute for Brain Research, Massachusetts Institute of Technology (2002) HONORS AND AWARDS (SELECTED): Otto-Hahn-Medaille of the Max Planck Society (1979) Member, Neurosciences Research Program (1979) Columbus Prize of the Istituto Internazionale delle Comunicazioni Genoa, Italy (1982) Corporate Fellow, Thinking Machines Corporation (1984) Founding Fellow, American Association of Artificial Intelligence (1990) Fellow, American Academy of Arts and Sciences (1997) Foreign Member, Istituto Lombardo dell’Accademia di Scienze e Lettere (1998) Laurea Honoris Causa in Ingegneria Informatica, Bicentenario dell’Invezione della Pila, Pavia, Italia, March (2000) Gabor Award, International Neural Network Society (2003) Okawa Prize (2009) Fellow, American Association for the Advancement of Science (2009) Tomaso Poggio began his career in collaboration -
Five Great Ideas of Biology
GREATGREAT IDEASIDEAS OFOF BIOLOGYBIOLOGY Paul Nurse KITP Public Lecture, Feb 24, 2010 THETHE CELLCELL The basic unit of life ROBERTROBERT HOOKEHOOKE’’SS MICROSCOPEMICROSCOPE Cork Image: Past Present STEMSTEM IMAGES:IMAGES: PASTPAST ANDAND PRESENTPRESENT Nehemiah Grew (1682) ANTONIANTONI VANVAN LEEUWENHOEKLEEUWENHOEK MICROORGANISMSMICROORGANISMS VANVAN LEEUWENHOEK?LEEUWENHOEK? THEODORTHEODOR SCHWANNSCHWANN “We have seen that all organisms are composed of essentially like parts, namely, of cells.” (1839) RUDOLFRUDOLF VIRCHOWVIRCHOW “Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life.” (1858) CELLCELL Rockefeller Nobel Prize Winners in Cell Biology George E. Palade (1974) Christian de Duve (1974) Albert Claude (1974) Günter Blobel (1999) MAMMALIANMAMMALIAN EMBRYOEMBRYO SPERMSPERM ANDAND EGGEGG THETHE CELLCELL The basic unit of life Underpins all reproduction and development Stem cells THETHE GENEGENE Basis of heredity GREGORGREGOR MENDELMENDEL MENDELMENDEL’’SS GARDENGARDEN PEASPEAS PEASPEAS 1919TH CENTURYCENTURY CHROMOSOMESCHROMOSOMES EDOUARDEDOUARD VANVAN BENEDENBENEDEN’’SS NEMATODENEMATODE CHROMOSOMESCHROMOSOMES PNEUMOCOCCUSPNEUMOCOCCUS Avery, MacLeod and McCarty, Rockefeller University (1944) DNADNA MOLECULEMOLECULE CENTRALCENTRAL DOGMADOGMA THETHE GENEGENE Basis of heredity Genotype to phenotype Implications for what we are EVOLUTIONEVOLUTION BYBY NATURALNATURAL SELECTIONSELECTION Life evolves Mechanism of natural selection ERASMUSERASMUS ANDAND CHARLESCHARLES DARWINDARWIN