Programme 2017 (Chemistry)
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CRISPR-Cas9 a New Tool for Genome Editing.Pdf
CRICRICRISSPSPEPERERRCCCaasas9s99 AA ANe Ne Neww wT To Toool olf olf orf orGe rGe Gennonomomem eE eEd Editdiitinitngingg ByB JyBen Jyen Jneninferinfer iDofer Do uDodunduand,a nK, aeK,v eKivnei nvDi noD xoDzxoezxnez,n ea,n a,d na dMn dMa rMatirnati rnJti nJie nJkienkek A AK eAKy eK yEe xEyp xEepxrepimreimenriment enpt rpto rpdorudocudecudec dbe ydb Tyb hTye hT eEh xeEp xElpoxlrpoelrore’srre ’Gsr ’uGs iuGdieud ietdo et oB t ioBo ilBooilgooylgoygy 2 The Explorer’s Guide to Biology https://explorebiology.org/ CRISPR-Cas9 A New Tool for Genome Editing Jennifer Doudna, Kevin Doxzen, and Martin Jinek Jennifer Doudna Jennifer Doudna is a professor in the Departments of Molecular and Cell Biology and the Chemistry and Chemical Engineering at the University of California, Berkeley. For her studies on CRISPR-Cas9, Dr. Doudna has received several awards including the Breakthrough Prize in the Life Sciences, the Japan Prize, and the Canada Gairdner Award. She has been leading efforts to discuss ethical uses of genome editing technologies. Doudna teaches in Bio 1A, an introductory biology class at UC Berkeley. Kevin Doxzen Kevin Doxzen, a former graduate student with Jennifer Doudna, is a sci- ence communications specialist at the Innovative Genomics Institute, which is advancing genome engineering using CRISPR technologies. 3 Martin Jinek Martin Jinek, born in Czechoslovakia and a former postdoctoral fellow with Jennifer Doudna, is now an associate professor in the Department of Biochemistry at the University of Zurich. Jinek received the EMBL John Kendrew Young Scientist Award and the Friedrich Miescher Award of the Swiss Society for Molecular and Cellular Biosciences. -
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MICHAEL GERRARD ‘72 COLLEGE HONORS FIVE IS THE GURU OF DISTINGUISHED ALUMNI CLIMATE CHANGE LAW WITH JOHN JAY AWARDS Page 26 Page 18 Columbia College May/June 2011 TODAY Nobel Prize-winner Martin Chalfie works with College students in his laboratory. APassion for Science Members of the College’s science community discuss their groundbreaking research ’ll meet you for a I drink at the club...” Meet. Dine. Play. Take a seat at the newly renovated bar grill or fine dining room. See how membership in the Columbia Club could fit into your life. For more information or to apply, visit www.columbiaclub.org or call (212) 719-0380. The Columbia University Club of New York 15 West 43 St. New York, N Y 10036 Columbia’s SocialIntellectualCulturalRecreationalProfessional Resource in Midtown. Columbia College Today Contents 26 20 30 18 73 16 COVER STORY ALUMNI NEWS DEPARTMENTS 2 20 A PA SSION FOR SCIENCE 38 B OOKSHELF LETTERS TO THE Members of the College’s scientific community share Featured: N.C. Christopher EDITOR Couch ’76 takes a serious look their groundbreaking work; also, a look at “Frontiers at The Joker and his creator in 3 WITHIN THE FA MILY of Science,” the Core’s newest component. Jerry Robinson: Ambassador of By Ethan Rouen ’04J, ’11 Business Comics. 4 AROUND THE QU A DS 4 Reunion, Dean’s FEATURES 40 O BITU A RIES Day 2011 6 Class Day, 43 C L A SS NOTES JOHN JA Y AW A RDS DINNER FETES FIVE Commencement 2011 18 The College honored five alumni for their distinguished A LUMNI PROFILES 8 Senate Votes on ROTC professional achievements at a gala dinner in March. -
Peter Agre, 2003 Nobel Prize Winner in Chemistry
SPECIAL COMMENTARY J Am Soc Nephrol 15: 1093–1095, 2004 Peter Agre, 2003 Nobel Prize Winner in Chemistry MARK A. KNEPPER,* and SOREN NIELSEN† National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and †Water and Salt Research Center, University of Aarhus, Aarhus, Denmark. Abstract. Peter C. Agre, an American Society of Nephrology somes after the incorporation of the purified protein. These member, is the recipient of the 2003 Nobel Prize in Chemistry findings sparked a veritable explosion of work that affects for his discovery of the aquaporin water channels. The function several long-standing areas of investigation such as the bio- of many cells requires that water move rapidly into and out of physics of water permeation across cell membranes, the struc- them. There was only indirect evidence that proteinaceous tural biology of integral membrane proteins, the physiology of channels provide this vital activity until Agre and colleagues fluid transport in the kidney and other organs, and the patho- purified aquaporin-1 from human erythrocytes and reported its physiological basis of inherited and acquired disorders of water cDNA sequence. They proved that aquaporin-1 is a specific balance. Agre’s discovery of the first water channel has water channel by cRNA expression studies in Xenopus oocytes spurred a revolution in animal and plant physiology and in and by functional reconstitution of transport activity in lipo- medicine. American Society of Nephrology member, Peter Agre of ing duct, revealed that the increase in water permeability was Johns Hopkins University, received the 2003 Nobel Prize in associated with the appearance of membrane particle aggre- Chemistry for his discovery of the aquaporins, a family of gates in the apical plasma membrane. -
DNA Repair Systems Guardians of the Genome
GENERAL ARTICLE DNA Repair Systems Guardians of the Genome D N Rao and Yedu Prasad The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar to honour their accomplishments in the field of DNA repair. Ever since the discovery of DNA structure and their importance in the storage of genetic information, questions about their stability became pertinent. A molecule which is crucial for the de- velopment and propagation of an organism must be closely D N Rao is a professor at the monitored so that the genetic information is not corrupted. Department of Biochemistry, Thanks to the pioneering research work of Lindahl, Sancar, Indian Institute of Science, Modrich and their colleagues, we now have an holistic aware- Bengaluru. His research ness of how DNA damage occurs and how the damage is rec- work primarily focuses on DNA interacting proteins in tified in bacteria as well as in higher organisms including hu- prokaryotes. This includes man beings. A comprehensive understanding of DNA repair restriction-modification has proven crucial in the fight against cancer and other debil- systems, DNA repair proteins itating diseases. from pathogenic bacteria and and proteins involved in The genetic information that guides the development, metabolism horizontal gene transfer and and reproduction of all living organisms and many viruses resides DNA recombination. in the DNA. This biological information is stored in the DNA Yedu Prasad is a graduate molecule as combinations of sequences that are formed by purine student working on his PhD and pyrimidine bases attached to the deoxyribose sugar (Figure under the guidance of D N 1). -
Channel Hoppers Land Chemistry Nobel Jim Giles Two Structural Biologists Credited With
news Channel hoppers land chemistry Nobel Jim Giles Two structural biologists credited with A. ABBOTT transforming our understanding of how cells work have been awarded the 2003 R. BOREA/AP Nobel Prize in Chemistry. Peter Agre of Johns Hopkins University in Baltimore and Roderick MacKinnon of the Rockefeller University in New York share the prize for experiments that revealed the intri- cate workings of the channels that allow ions and water to enter and leave cells. MacKinnon is perhaps the most widely tipped Nobel winner of recent years.In a land- mark 1998 paper (D. A. Doyle et al. Science 280, 69–77; 1998), he and his colleagues pro- vided the first detailed three-dimensional Roderick MacKinnon (left) and Peter Agre’s work on cell-membrane proteins has won them recognition. picture of a protein that acts as a channel to control the flow of potassium ions across cell deserved a Nobel.“His work is a tour de force,” Kuhajda and P. Agre J. Biol. Chem. 263, membranes. This channel is immensely says John Walker, a structural biologist at the 15634–15642; 1988). “No one had seen it important to neuroscientists, as the flow of University of Cambridge, UK. “The award is before,but we found that it was the fifth most potassium ions helps to generate the voltage absolutely spot on and richly deserved.” abundant protein in the cell,” says Agre. pulses that brain cells use to communicate. MacKinnon was on holiday when the “That’s like coming across a big town that’s Before MacKinnon’s paper, many biolo- prize was announced, and couldn’t be not on the map.It gets your attention.” gists had questioned whether the technique informed directly by the Nobel prize com- The protein, now known as aquaporin 1, he used — X-ray crystallography — could be mittee. -
Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. -
Dear Colleague, This Invitation Is Being Sent on Behalf of Prof
Dear colleague, On behalf of Prof. Fernand Marquis (San Diego State U., USA), Prof. Soteris Kalogirou (Cyprus U. of Technology, Cyprus), and Prof. Bernard Raveau (U. of Caen, France), co-chairs of the 2nd International Symposium on Solid State Chemistry for Applications and Sustainable Development in my capacity as President of SIPS 2020/2021, I am personally inviting you to participate as an author/speaker. This major symposium focuses on solid-state chemistry corresponds to the relationships occurring between the synthesis, structure, and physical-chemical properties of solid inorganic compounds (in most cases), leading to a final compound with optimized properties such as advances in the synthesis routes, design of materials for sustainable energy production, advanced characterization techniques and applications, etc. These and many others are among the topics of the symposium. This symposium will be held as part of the combined SIPS 2020/2021, an annual multidisciplinary summit, organized by the not-for-profit corporation FLOGEN Stars Outreach (www.flogen.org), which is dedicated to achieving sustainability through science and technology applied in various fields. It incorporates summit plenary lectures from well-known speakers that address the link between various domains in the pursuit of sustainable development, as well as specific scientific symposia featuring specialized presentations in a specific domain, with the same goals in mind. The symposium and overall summit are planned to be held in Phuket, Thailand from November 28th – December 2nd 2021. We have confirmed until now the participation of the following 9 Nobel Laureates: Prof. Dan Shechtman, Prof. Didier Queloz, Prof. M. Stanley Whittingham, Sir Konstantin Novoselov, Prof. -
N E W S I N B R I
N E W S I N B R I E F NOBEL PRIZE IN MEDICINE The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for elucidating At the height of the Vietnamese war, the common enemy of three different mechanisms by which errors occur in our DNA soldiers on either side of the battle lines was chloroquine- and the various mechanisms of DNA repair. In the 1970’s, resistant malaria. In 1964, the North Vietnamese Government Lindahl discovered that DNA undergoes regular decay and approached the Chinese leader Mao Tse Tung to find a damage. For example, cytosine loses an amino group to become solution to this deadly scourge. Mao immediately established uracil resulting in a mutation. Subsequently, he discovered an a military mission Project 523 with a main aim to discover a enzyme system called uracil-DNA glycosylase which corrects drug for resistant malaria. Youyou Tu was a phytochemist who this error. This process was called base excision repair. Aziz was in charge of the project. She and her team combed through Sancar discovered and cloned the gene for an enzyme called hundreds of old Chinese traditional medicine texts. Around photolyase which is critical in correcting DNA mutations caused 2000 chemicals extracted from various plants were evaluated. by high doses of UV exposure. He further went on to identify the Finally, they zeroed on to an extract of Artemesia annua L. exact chemical processes involved in this nucleotide excision also called Quinhao which was found to have excellent repair. Paul Modrich discovered the mechanism by which DNA antimalarial efficacy in a mouse model. -
Nobel Week Stockholm 2018 – Detailed Information for the Media
Nobel Week Stockholm • 2018 Detailed information for the media December 5, 2018 Content The 2018 Nobel Laureates 3 The 2018 Nobel Week 6 Press Conferences 6 Nobel Lectures 8 Nobel Prize Concert 9 Nobel Day at the Nobel Museum 9 Nobel Week Dialogue – Water Matters 10 The Nobel Prize Award Ceremony in Stockholm 12 Presentation Speeches 12 Musical Interludes 13 This Year’s Floral Decorations, Concert Hall 13 The Nobel Banquet in Stockholm 14 Divertissement 16 This Year’s Floral Decorations, City Hall 20 Speeches of Thanks 20 End of the Evening 20 Nobel Diplomas and Medals 21 Previous Nobel Laureates 21 The Nobel Week Concludes 22 Follow the Nobel Prize 24 The Nobel Prize Digital Channels 24 Nobelprize org 24 Broadcasts on SVT 25 International Distribution of the Programmes 25 The Nobel Museum and the Nobel Center 25 Historical Background 27 Preliminary Timetable for the 2018 Nobel Prize Award Ceremony 30 Seating Plan on the Stage, 2018 Nobel Prize Award Ceremony 32 Preliminary Time Schedule for the 2018 Nobel Banquet 34 Seating Plan for the 2018 Nobel Banquet, City Hall 35 Contact Details 36 the nobel prize 2 press MeMo 2018 The 2018 Nobel Laureates The 2018 Laureates are 12 in number, including Denis Mukwege and Nadia Murad, who have been awarded the Nobel Peace Prize Since 1901, the Nobel Prize has been awarded 590 times to 935 Laureates Because some have been awarded the prize twice, a total of 904 individuals and 24 organisations have received a Nobel Prize or the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel -
The Nobel Foundation Annual Review 2018
THE NOBEL FOUNDATION ANNUAL REVIEW • 2018 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 1 1901 WILHELM CONRAD RÖNTGEN The first Nobel Prize in Physics was awarded to Wilhelm Conrad Röntgen for his discovery of X-radiation. The X-ray tube pictured on the cover is on display at the Nobel Prize Museum. Photo: Alexander Mahmoud 2018 BERNICE A. KING “I wish to commend the Nobel Museum for (…) this new exhibition. I believe that my parents’ message of social justice and equality is as important today as ever before.” The exhibition A Right to Freedom - Martin Luther King, Jr. was inaugurated by King’s daughter Bernice A. King at the Nobel Prize Museum on 28 September 2018. Photo: Alexander Mahmoud 2 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 3 For the greatest beneft to humankind ALFRED NOBEL 4 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 “I can tell you how. It is very easy. The first thing you must do is to have great teachers.” Paul A. Samuelson, 1970 Laureate in Economic Sciences, on how to earn a Nobel Prize. obel Laureates often Luther King, Jr., and with a Nobel Prize attest to how crucial Teacher Summit on the theme Teach their teachers have been. Love and Understanding, with 350 Teachers, researchers and teachers from 15 countries attending. others who contribute Al Gore, the 2007 Peace Prize Lars Heikensten, Executive Director Nto increased knowledge are the heroes Laureate, addressed How to Solve the of the Nobel Foundation since 2011. and heroines of our age. When the very Climate Crisis when he spoke at the 2018 Photo: Kari Kohvakka idea of science is being questioned, our Nobel Peace Prize Forum in Oslo. -
Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A. -
Aziz SANCAR WINS Nobel Prize
Advancing SCIENCE Aziz Sancar, 2015 Nobel laureate in chemistry extremely proud that he is a member of TWAS, and we offer him heartfelt congratulations.” Sharing the prize with Sancar are two other chemists who have made pioneering discoveries in gene repair: Swedish native Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in Hertfordshire, UK, and American Paul Modrich of the Howard Hughes Medical Institute and Duke University School of Medicine in North Carolina. “Systematic work” by the three researchers “has made a decisive contribution to the understanding of how the living cell functions, as well as providing knowledge about the AZIZ SANCAR molecular causes of several hereditary diseases and about mechanisms behind both cancer development and WINS NOBEL PRIZE aging,” the Royal Swedish Academy of Sciences said in announcing the prizes. by Edward W. Lempinen Sancar, 69, was born in Savur, a small town in southeastern Turkey. The Turkish-born DNA to remove the damaged genetic He was the seventh of eight children. code. His initial discoveries at Yale “My parents were both illiterate,” he scientist, elected to TWAS University in the United States focused said in a 2005 profile published in the in 1994, shares the 2015 on E. coli bacteria; more recently, at Proceedings of the National Academy the University of North Carolina in the of Sciences (USA), “but they valued the Nobel Prize in chemistry United States, he detailed the workings importance of education and did their of this DNA repair in humans. best to ensure that all of their children for research into DNA Sancar is the first native of Turkey to would receive some education.” repair.