July 24, 1990 Vol. XLLI No- 15 "The Second U.S. Depanment of Health Best Thing and Human Services About Payday"

National Institutes of Health e Recori How're We Doing? Whose Genome Is it, Anyway? NIH Claims Ten Percent of Decade's By Leslie Fink Hundred Most-Cited Scientists A quick glance around any public gathering By Carla Garnett will attest to the physical diversity of che human population. In most groups of people, Intramural NIH has distinguished itself in The JO NIH researchers found in the top some will be call, ochers may be hefty; some one of the most competitive areas of biomedi­ 100 most-cited scientists of the decade are will have brown eyes, and ochers blue. Physi­ cal science-publication of research. According Iiseed below. cal arcribuces such as height, complexion, and to a recent issue of The Scientiit, 10 NIH Dr. Robert Gallo, chief of NCI's Laboratory hair and eye color are largely determined by researchers are among the cop 100 most-cited of Tumor Cell Biology and codiscoverer of the genes-packets of the genetic material DNA, scientists of the 1980's. The list was compiled HIV virus, is the world's most-cited scientist which are located on chromosomes. from the files of Science Citation index, a pub­ of che lase decade, collecting more than The complete set of human genes, collec­ lication of the Philadelphia-based Institute for 23,000 citations of his articles. His most cited tively called che human genome, is made up Scientific Information (ISI). paper was published in Science in 1984, had of about 3 billion chemical subunits called "We're very proud that a number of our been cited almost 1,500 times by December nucleotides. A research initiative called the prominent scientists have been recognized by 1988 and is che 10th mosc-ciced article of the human genome project is now under way to their publications," said Dr. Philip Chen, decade. map all the genes on human chromosomes and NIH associate director for intramural affairs. NIAID director Dr. Anthony S. Fauci, who to determine the order, or sequence, of the 3 Chen's work was recently lauded as well in is also NIH associate director for AIDS billion nucleotides. So as scientists begin to another ISI publication, Current Contents: His research, and chief of NIAID's Laboratory of map and analyze the molecular details of the L956 methodology paper on microdececcion of lmmunoregulacion, is the eighth mosc-ciced complete sec of human genes, whose will it phosphorus has drawn more than 5,400 cita­ scientist during 1980 to 1988. He is also be? tions, making it one of the most-cited articles author of che most-cited paper in medicine in In many ways, describing the anatomy of of all time. the last 2 years; his review, "The human che human genome will be similar co studying Another NIH'er made the all-time list­ immunodeficiency virus: Iofecciviry and che human heart, for example, or the human Dr. Martin Rodbell of NIEHS. His 1964 arti­ mechanisms of pathogenesis," published in a brain. While there are small differences from cle on the metabolism of isolated fat cells has February 1988 Science, has already garnered person co person in the size and shape of these collected more than 2,800 citations over 40 more than 300 citations. organs, most of the key characteristics are the years. The ISi index covered citarions of pub­ Dr. Ira Pascan, chief of the Laboratory of same. "Although human beings are distinct lications back co 1945. Molecular Biology at NCI, has been among from one another, they are really very similar "There are various measures of a scientist's the top 50 most-cited researchers since 1965. (See GENOME, Page 7J impact," Chen continued_ "There are prizes For the period covering 1980 to 1988, he won, awards conferred and citations. That ranks 33rd. His most cited paper during chat Never Too Late To Learn NIH, by virtue of having 10 highly cited time is "Journey co the center of the cell: Role sciencists--and actually many more--has had of,he recepcosome," which was published in Training Offered to Veteran chis great an impact on the science of ocher Administrators researchers is very important."

TOP PAPERS decade-NCI Surgery Branch chief Dr. Steven Rosenberg, who wrote the 1982 Journal of (Continued from Page 1. ) Experimental Medicine paper, "lymphokine-acri­ vated killer-cell phenomenon: Lysis of natural­ Scienre in L98 L and collected close to 400 killer resistant fresh solid tumor cells by citations. interleukin-2 activated autologous human NCI Metabolism Branch chief Dr. Thomas peripheral-blood lymphocytes," chat was cited Waldmann is number 34 of the top 100 most­ more than 680 times through 1988. cited scientists. His most cited paper during Rosenberg's crue ranking could nor be the 1980's is "A monoclonal antibody (anti­ ascertained by 1S1 because another S.A. Tac) reactive with accivaced and functionally Rosenberg-Saul A., who conducts oncology mature human T cells," which was published research at Stanford University-was also in the Journal of Immunology in 1981 and had highly cited. The Rosenbergs' papers are com­ collecced 843 citations by the end of 1988. mingled in ISI data files. The Scientist Waldmann collected almost 6,800 citations estimated chat articles wrircen by NIH's S.A. overall from 1980 co L988. Rosenberg have heen cited more than 5,000 Dr. Stuart Aaronson, chief of the laboratory times through the 1980's. of Cellular and Molecular Biology at NCI A final interesting point noted by The Scien­ University of Toronto officials have named NJNDS since 1977, is the 46th most-cited scientist in tist-all 10 of these highly cited scientists are sciemist Dr. Milton \11/. Brightman as the first the lase decade. According to ISi , his 1982 career NIH'ers with 27 years average length of recipient of the new international Cragie Scholar PNAS-Biology article, "Translocation of the service. 0 Award, given biennially "to recognize classic work c-myc gene into the immunoglobulin heavy­ in the field of brain capillaries." Brightman. chief chain locus in human Burkitt lymphoma and of the brain structural plasticity seaion, Laborat&ry murine plasmacytoma cells,·• amassed more of Neurobiology, discussed NINDS research on ways than 560 citations through 1988. of bypassing the btood-brai11 barrier during the NCI Laboratory of Chemoprevencion chief keynote address at the first C ragie Conference on Dr. Michael Sporn was cited almost 370 times Brain Capillaries on June 24. Dr. E. Horne for his paper, "Transforming growth factor-b Cragie, who died last year, was one of Brightman's in human platelets: Identification of a major professors at the University of Toronto while storage site, purification, and characteriza­ Brightman was st11dyi11g for his master's degree. tion," published in 1983 in thejournal of Biological Chemis11y. He is the 51st most-cited scientist of 1980 co 1988. Dr. William Paul, chief of the laboratory of Immunology at NIAlD, was the 53rd most-cited scientist during the 1980's, collect­ ing close to 5,680 citations by 1988. His The NIH Record mosr-cited paper, "Identification of a T-cell Published biweekly at Bethesda, Md., by the Editorial derived B-cell growth factor distinct from Operacions Branch, Division of Public Information, for rhe intedeukin-2," was published in a 1982 information of employees of the National lnsrirutes of Journal of Experi1nental Therapeutics. That paper Dr. L-Ouise E. Ramm has been appointed dil-ecto1· of Health, Department of Health and Human Services, and collected more than 5 30 citations by 1989. the Biological Models and Materials Program at circulated to nonemployees by subscription only through NHLBI Pulmonary Bra~ch chief Dr. the Natio11al Center for Research Resources. Ra1llm rhe Government Priming Office. The conrenr is reprintable Ronald Crystal, whose 198 L American J 011rnal began her career at N 1H as a health scientist without permission. Pictures may be available on request. of Medicine paper, "Interstitial lung disease: administrator with the biological models and Use of funds for printing this periodical has been approved current concepts of pathogenesis, staging, and materials seaion of the Animal Resources Program by the directOr of the Office of Management and Budget through September 30, 1990. therapy, .. collected about 300 citations, is and became acting diroctor when the section became 59th among the 100 highJy cited researchers a program in 1989. Prior 10 coming Jo N IH, she N IH Record Office Staff Correspondents: through 1988. served on the faculty of the mo/ocular biology and Bldg. 31, Room 2B-03 CC, Ellyn Pollack Phone 496-2125 DCRT, Anica S. Ferguson Dr. John Daly, chief of the Laboratory of genetics department at Johns Hopkins University Bioorganic Chemistry at NIDDK and collector fAX 496-0019 DRG, Sue Meadows school of medicine for 5 years. Ramm received her F(C, Louise Williams of more than 5,220 citations overall, ranks Ph.D. in microbiology from the University of Editor NCI, Patricia A. Newman 62nd among the top-cited scientists. Virginia. Richard McManus NCNR, Gerry Pollen According to The Scientist, his total citation NCRR, Polly Onderak Assis1ant Edi1or NEI, Claudia Feldman count "reflects numerous high-impact papers Anne Barber NHLBI, June Wyman rather than one or two blockbusters." lSI IMPAC Data Base Course Offered NlA. Margo Warren reports that at least 10 of Daly's papers have Staff Writer NI.AID, Ann C. London been cited more than 300 rimes each. His DRG will be teaching a course on che Carla Garnett NIAMS, Barbara Weldon most cited paper during the 1980's was "Adc­ Inquiry and Reporting System, which is a pro­ N(CHD, Carol Florance Edi1orial Assistam NIDCD, Karen L. Jackson nosine receptors in rhe central nervous system: gramming language used co query che IMPAC Marilyn Berman N IDOK. Eileen Corrigan Relationship to che central actions of merhyl­ data base. The course will be given on Aug. Th, NIH R""d reserves che right NIDR · Mary Daum xanchines," published in a 1981 issue of Life I, 2, 3, 8, 9 and 10 in Bldg. 12A, Rm. to make c:orrcccions, changes, or N1EHS, Hugh J· Lee Sciences. B45. A knowledge of Wylbur is required. For delmons ,n '"bmiired copy in NIGMS, Wanda Warddell One other NIH researcher was recognized m further information, contact Carol Bleakley, conformity with the po1icits of che NINOS1 Carol Rowan p•per and HHS. NLM, Roger L. Giikeson ]Si's cop 100 top-cited scientists of the last 496-7217 or Brenda Grimes, 496-7864. D page ' The Record July 24 , 1990

Dental Researchers Link Smokeless Tobacco to Oral Lesions

A study of professional baseball players tobacco use in the general population ranges indicates that using smokeless tobacco from about 4 percent to 11 percent among increases the risk of developing oral lesions males who are anywhere between their late and gum problems, according to dental teens and 39 years of age. researchers at the University of California, San ln the baseball study, about three times as Francisco. many players used snuff as used chewing Study results appear in two separate articles tobacco. Only 4 percent of the players were in J uly----one in the journal of the American cigarette smokers. Medical A.uociarion and another in the journal Of those classified as within-week users, 46 of the American Dental Association. percent had oral leukoplakia lesions, a leath­ "This is the most comprehensive study of ery-appearing white or yellowish patch inside its kind," said Dr. Ha.raid Ll:ie, director of the the cheek. Snuff users had a much higher National Institute of Deneal Research, which prevalence of oral leukoplakia (55.6 percent) supported the study. "These findings show us than did tobacco chewers (17.2 percent). chat smokeless tobacco is harmful to the oral The researchers believe that snuff might be tissues and chat further research in this area is more dangerous to oral health because it is warranced." held in one place in rhe mouth (a "pinch"), The study focused on 1, 109 baseball players unlike chewing tobacco, which is held loosely in the cheek (a "chew") and may move during spring training in 1988. Members of Dr. Susar, M. Pilch recently was appointed deputy around. Also, snuff generally has higher levels seven major league teams and their associated director of the Division of Nutrition Research minor league teams participated: the San Fran­ of nicmine and ocher carcinogenic substances Coordination (DNRC), Office of Disease cisco Giants, California Angels, Cleveland than does chewing tobacco. Prevention, OD. The DNRC coordinates the NIH Indians, Milwaukee Brewers, Oakland Ath­ Snuff users were more likely than nonusers nutrition research artd training activities supported letics, Seattle Mariners, and Chicago Cubs. to have separation of gums from teeth at the by its !CDs; a major component of the DNRC iJ The researchers examined basebalJ players sire where the tobacco is usually held. The the NIH nutrition coordinating committee. Pilch because of their high rates of smokeless researchers stressed that such periodontal dis­ received her B.A. from the University of Virginia tobacco use and because they are role models ease would probably nor be reversible, even if and her Ph.D. fro111 Cornell University , She was for young men. They assessed the effects of smokeless tobacco use was stopped. fonnerly on the staff of the Life Sciences Research snuff--a finely ground or shredded tobacco-­ Despite the fact that baseball and smokeless Office, FASEB, where she was project leader for a and chewing tobacco--a more coarsely cut tobacco have been seen as partners for a long variety of studies on nutritional status assessment, tobacco packed in loose or plug form. rime, things are beginning to change. Many nlllrition monitoring, and other topics, and served Thirty-nine percent of the players had used reams such as the San Francisco Giants have as an assiJtant editor for the American Journal of smokeless tobacco during the previous week, a banned the availability of free smokeless Clinical Nutrition. much higher rate than that found in the gen­ tobacco products in their clubhouses and now eral population. According to recent national provide information to players on the health survey data, the prevalence of smokeless effects of smokeless tobacco. 0

Day Care Subcommittees Need Volunteers

Day care surveys were distributed to the the current day care services at NIH and make NIH community in early January. At that recommendations for additions and changes; time the NIH day care committee received • Fund raising subcommittee to search out names of employees interested in volunceering methods of raising money needed co subsidize and is now extending the invitation again. As tuition and equipment costs; a result of the survey, a need for five subcom­ • Family day care network subcommittee mittees has been defined co further explore ro explore the desirability and feasibility of and evaluate day care needs and options at maintaining a network of NIH-sponsored NIH. family day care homes used to care for NIH Subcommittees are as follows: employees' children. • Central oversight subcommittee to If you are interested in participating in any develop policies and procedures for monitoring of these subcommittees, please use an inter­ NIH day care services; office envelope to send your name, NIH Dr. Norka Ruiz Bravo has been appointed • Day care referral subcommittee to inves­ address, telephone number and subcommittee executive secretary of the Minority Accers to Research tigate options for creating and implementing a that interests you co: Paul R. Horton, Direc­ Careers review subcormnittee i'rt the National resource service that would make information tor, Division of Space Management, Suire lwtitllfe of General Medical Sciences. Bravo, a about day care (tuition subsidies, sick child 200, Executive Plaza South. native of Peru, received her Ph.D. from Yale care, elder care, etc.) avai !able ro NIH Send in your responses by Aug. 16 so that University. She comes to NIH from Baylor College employees; the subcommittees may be organized and con­ of Medicine where she had been an assistant • Current NIH day care services subcom­ vened. If there are any further questions, call professor doing research in the lkpartments of mittee to work with a consultant to evaluate Horton, 496-3172. 0 urology and cell biology sirtce 1987. page 4 The Record July 24, 1990

HSA TRAINING "A PDA," he continued, "would be a good opportunity to go across NIH and the depart­ (Continued from Page J ) ment to assemble a broad view of an issue." "It's basically an invent-it-yourself pro­ Kale's last assignment---discovering how gram," he explained. "It's for people who have issues develop across government agencies­ been around long enough to know what they involved formal course work at the Federal don't know." Executive Institute and the Office of Personnel Open co HSAs with at least 3 years of expe­ Management, plus interviews with top-level rience, the PDA offers 4-12 weeks of training managers in Bldg. 1, including Dr. William spread out over 2 years. Kale signed on in lace Raub, now acting N1H director. 1988 following conversations wirh A. Robert Kale acknowledges that his present position "Tony" Polcari (see sidebar) and just recently ac the Senior Executive Service level in NCI finished his training. owes, in pare, co a PDA assignment in that "I wanted co gee broader experience," he institute. said. "It turned our co be a golden "h 's just a coincidence that I did a rocarion opportunity." in rhe institute chat eventually hired me," he Trained in cellular, developmental and said. "But chat assignment gave me a tremen­ dous advantage in learning the specifics of my reproductive biology, Kalt came co NIA in Dr. Marvin Kalt 1980 as an executive secretary. He had been job. There are 2,000 people in NCI, so any assistant professor of anatomy at the Univer­ they're doing but haven't had che breadth of a advantage is important co have." sity of Connecticut Health Center where his few jobs at NIH," he said. "Jc gives you the Kale says he has a Joe more cime these days work on germ cell development and differen­ license to walk in virtually anywhere relevant to devote to policy issues rather than co review tiation had been supported by NICHD and co your goals and get training." of specific applicarions. "Being able co do chat the National Science Foundation. Prior to chat Kale's goals were shaped in pare by the pre­ was really the goal of my PDA experience. he had done an N IGMS-sponsored postdoc­ ceptor to whom he was assigned-Dr. Ernest This is the kind of job I thought I'd be most toral fellowship at Yale. Johnson, a former GA who now directs inceresced in." ''Ac the university, I was interacting with NIDDK's Division of Diabetes, Endocrinology Admitting rhac he misses research "a lit­ scientist administrators all the time," he and Metabolic Diseases. The two planned a tle," Kalt says, "l have never felt that l made recalls. "Realizing that grant money would be PDA chat included: the wrong decision. One of the things NIH harder, not easier, co gee made me consider Five weeks learning program planning and teaches you is what the difference is between careers ocher than straight research. NIH gives evaluation with Dr. Barbara Packard, being good in a field and being the best. I'm out al! the grant money and seemed like a NHLBl's planning director. "That caught me glad to be a scientist administrator and not a how broad goals ac NIH are sec," said Kalt, bench scientist." "One of the best parts of the program is who wrote a report on the effectiveness of Employees who chink an HSA training pro­ NHLBI training programs while on assign­ gram might be broadening may call che Office that it gives you a rearon to talk to the ment there. of Health Scientist Administrator Develop­ experts. Just listening to them for an hour or "Very often there is a specific product asso­ ment Programs, 496-1736. two about what their day-to-day life was ciated with these rotations," he related. like ... gave me imights." Six weeks (spread out over 3 months) with Polcari Plays Matchmaker Role Dr. Faye Austin, acting associate director for There may be no more capable a match­ the extramural research program at NCl's goo

Metropolitan Mental Health Problems. ln "It's a very selective program," he says. FAES Offering Stipends 197 4, he returned co NIH as assistant to the "We gee 100 new applications for the GA chief of the Office for Protection from Program every year. Seventy percent are raced Research Risks. Polcari became executive sec­ eligible, but only half of those gee high FAES is administering special funds known retary of the Granes Associate (GA) Program enough priority scores ro be reviewed by the as Wellcome Stipends co augment the stipends in 1975 and today oversees the four HSA GA board. Of them, one third are inter­ of posrdoccoral level guest workers at NIH. training programs-GA, newly hired, HSA viewed, then only one third are selected. At Depending on the total funds chat are avail­ trainee and professional development the end of their year, however, they are ready able and the number of eligible applicants, a assignment. for any HSA assignment." maximum of $3,600/year ($300/month) may So much for his history on paper. What he Only five GAs are accepted for training be granted ro each approved individual as an really has co offer appears on no resume. each year. The other HSA training programs income supplement co a maximum rocal "When someone comes into our program, I currently enroll about 20 people. family income of $15,000/year plus $-1,000 cry to gee under their skin and see what the "A couple of times a week J hear from for each dependent including spouse. problems are," says Polcari, crediting his years interested members of intramural NIH," says The selection committee will consider the of social work with preparing him for this job. Polcari. "Calls from extramural NJH come in scientific meric of the research co be conducted "I cry co learn what dicks and what helps get daily." as well as need and professional qualifications Though many credit him with rejuvenating of the applicant. their careers, Pokari is modest and low-key Awards will be made twice a year, Mar. 3 1 about his talent: "If you're around long and Sept. 30 for the 12-monch period begin­ enough, you learn a few things. NIH is just a ning Apr. land Oct. 1, respectively. special agency and I've been with it for years. Applications for 1990 must be received in the Age and experience are the key." FAES office on or before Aug. 24 for the Reconsidering, he gives all the credit co his September awards. Applications are now being assistant Roberta Light, who has been with accepted. him since 1976. "Roberta really runs the pro­ Additional application forms are available gram, not me. She's just fantastic." D from the FAES business office, Bldg. 10, Rm. BIC18 or by calling 496-7976. 0

Office Supply Show Planned NIMH Seeks Volunteers NLM will sponsor an office produce show A. Robert Polcari featuring free samples and demonstrations by NIMH seeks volunteers co participate in a the 3M Company on July 27, 1.1 a.m.-2 p.m. study using an innovative treatment for people off the ground. I try to hear between in Bldg. 31, Conf. Rm. 10. For more depression. All services and medications are the lines and read between the lines. Also, 1 information, contact Rob Morrison, free. For more information call 496-6981 or keep close contact with people." 1-800-241-3669. 0 496-2141. 0 "Tony is the kind of person who instills self-esteem," says Tommie Sue Tralka, one of his trainees. 'Tve seen people go into his GA program who appear beaten and they srarc out with this wounded look. But after a year in the GA Program they come out with their chests out, feeling good about themselves. They' re prepared. "Ir scares me for when he retires," Tralka continues. "It's terrible co chink that one per­ son could have so much impact. I'm not sure what it is about Tony but he gives you the sense chat you can do anything. I can't imag­ ine how he could be replaced." Says Polcari, "You gee a feel for peoples' strengths after knowing chem for a few months. l try not to push." If there is any secret co his skill, Polcari says it is that he "gees ro know (trainees) as people. l try to support where their real motivations lie. These people aren't leaving science or their research careers at all. By managing portfolios of grants, they are expanding their research, not narrowing it." There are some 700 HSAs working at NIH. Jennifer Price, the 1990 Asthma and Allergy Foundation of America pouer child, displa)'S a Camp NIAID Roughly 10-15 percent of them are graduates T-shirt presented to her at the recent dedication of the NJAJD Asthma and Allergic Diseases Center located of either GA, newly hired, or HSA trainee in the Clinical Center d11ring Natio11£1l Asthma and Allergy Awareness Week, Looking on are (from I) programs--all voluntary- run by Polcari. The Dr. J ohn Gal/in, director of the Division of Intramural Research, NJAID; Dr. Anthony S. Fauci, GAs get most of his attention, as he is their NJA ID director; Dr. Michael A. Kaliner, head of the allergic diseases section of the NlAID Laboratory of prime supervisor and career counselor. Clinical Investigation; and Dr, Dean D. Metcalf, head of the mast cell physiology section of the LCJ. page 6 'Ire Record July 24, 1990

Introducing Science to the Young Singer Starts Science Program for Carnegie Institution

By Carol R. Cronjn

To most kids their age, jeans are found in department scores. But to the students of che Carnegie Institution of Washington·s "'First Light" science program, genes are found on chromosomes and involve an entirely different process of selection. First Light's recent visit co NIH was pare of a special program currencly being developed by the NIH Visitor Information Center's (VIC) Learning Laboratory. The First Light program got under way in 1989, after a year of planning by Carnegie's president Dr. Maxine Singer (formerly chief of NCI's Laboratory of Biochemistry and now NCI scientist emeritus), with the help and enthusiastic support of many ochers. "We went to neighborhood schools and churches and told people about the program," said Singer, who became frustrated with the more traditional selection procedure. Students are accepted for the program on a first-come, first-served basis. Students in the program range ·in age from Volunteer teacher Dr. Julie McMillan of NCI demonstrates DNA electrophoresis for First Light students (from I) Nick, Asha, Janine, Tai, Janelle and Rashard.

Photos: Ernie Branson

StudentJ (from /) Janelle, Asha and Rashard get the feel of a scie11ti1t's white coat.

8 to 10 and attend area elementary schools such as Garrison or Ross within the neighbor­ hood of che Carnegie Institution, located at 16th & P Scs., NW. The students meet every Saturday to focus on a program chat begins, first, in their laboratory. "We emptied our an old shipping room," said Singer. The lab session is followed by a field trip designed to heighten the awareness of the students, perhaps helping chem to choose science as a career path. Trips have included such places as the National Aquar­ ium in Baltimore, the Naval Observatory, and ✓ the Smithsonian's "Dinamation" exhibit featuring 18 robotic dinosaurs. Dfrect()I' of First Light Charles James and Dr. Maxine Singer demonstrate the automatic blood pressure First Light has become informally connected machine to students Rashard and Brandon ( 2nd from r ). to NIH, utilizing the strengths and volunteer page 7 TheRerord July 24, 1990

efforts of NIH postdocs, some of whom work GENOME with Singer at NCI laboracories. "The kids are exposed co real scientiscs," said Singer. (C4Jntinued from Page JJ But science does not live by scientists alone. As First Light's operating expenses have in mosc biologically important respects," says are caused by malfunctioning genes located on grown, so have contributions, which have Dr. Mark Guyer, National Center for Human the X chromosome. come from local foundations and other scien­ Genome Research's assistant director for pro­ To get cells chat contain only che chromo­ tists in the Washington area. Funding has gram coordination. "Thar's whac makes us some piece they are interested in, scientists included personal grants from Dr. Roberc human. So the map of che human genome can have developed ways co fuse human cells with Gallo of NCI and Dr. James Watson, director really be based on information collected from rodent cells in culture dishes. Growing these of che National Center for Human Genome many different people. And most of the infor­ human-rodent "hybrid" cells in special Research. mation in that map will pertain co everyone." nutrients selects out specific human chromo­ Geneticists estimate, for example, that any somes, while the ochers are gradually knocked two people are about 99 percent similar in ouc. Hybrid cells containing human chromo­ their genetic makeup. The tiny differences somes have now been developed for nearly all between any rwo people rest in only 2 to 10 of the 24 different human chromosomes. Mose million (out of che 3 billion total) nucleotides, of these cell lines are scored in commercial cell an amount thac computes to about 1 percent repositories where they are disrribuced co any or less of their total DNA. "Because these scientist who wanes co study chem. small differences vary from person co person," For several decades, geneticisrs searching for says Guyer, " it doesn't matter whose genome disease genes have studied human cells main­ it is. For some studies, the differences will be cained in the laboratory. These cells originally the focus of interest. In other cases it will be came from people who have an inherited dis­ che similarities." ease, from their healthy relacives who are Eventually, scientists will "map," or estab­ carriers, or from ocher unrelated healthy peo­ lish distinctive genetic landmarks, from one ple. Bue because human cells do nor ordinarily end of a chromosome to the other and add survive long under laboratory conditions, sci­ First Light student Lindsay examines cells through chat information co the genetic map of the enciscs have had to invent ways co keep the a microscope during a visir to NIH. entire human genome. This complete map cells alive long enough to perform detailed will become rhe "reference" co which studies of DNA inside the cells. Asked why she started che program, Singer researchers will compare DNA caken from a Since almost all cells in the body contain responded, ''I've served on a lot of commit­ variety of people as scientists look for disease the same genetic information, nearly any type tees. Through chem all, I came to the same genes and other imponanc generic regions of cell can be used as a source of DNA. A conclusion. Instead of wasting my rime, I'll located on chromosomes. A parcicular region type of white blood cell called a lymphocyte is stare a school for small children." on a chromosome, for example, may be found commonly used because it is easy to obtain Singer credirs many people with the success to contain information about height. Although from a blood sample. To gee the cells co last of First Light. Among rhem is Charles James, che genetic content of that specific site may longer in the laboratory, scientists infect lym­ its director and primary science teacher. change slightly from person to person, the phocytes in the test cube with a common virus "I interviewed many people," said Singer, location of che sire will be the same in each known as EBV. This virus, che cause of mono­ "but he understood what science is all about. person's genome. nucleosis, incerrupcs the cell's normal life cycle He almost never answers a question bur leads Because studying the entire 6-foot screech of so it literally doesn't know when co die. Cells the kids to an answer." human DNA is a huge project, scientists are "immortalized" by EBY chen grow and divide For further information about arranging a tackling the genome one chromosome at a indefinitely in laboracory cultures, providing program in the VIC Learning Laboratory, con­ time. Even chen, analyzing the generic con­ researchers with unlimjced amounts of human tact the Visitor Information Center, cent of jusc one chromosome is an enormous DNA for genome studies. 496-1776. 0 cask for a single research group, so many sci­ "The ultimate goal of the genome projecc is entists are studying only portions of a co have the technology and ability to check Sailing Club Lessons, Open House chromosome. The complete map for a single pares or all of many genomes," says Dr. David chromosome then will be derived from sam­ Schlessinger, direcmr of the Center for The R&W Sailing Club will hold a picnic ples collected from several unrelated people by Genetics in Medicine at Washington Univer­ and open house on Saturday, July 28 (rain researchers in many different laboratories. sicy in Sc. Louis. "We will analyze one dace July 29) from lO a.m. to dusk at Selby Dr. David Ledbetter and his colleagues at genome relative co another, and chat's pare of Bay Sailing Center in Edgewater, Md. The the Baylor College of Medicine, for example, the interest in chis project. There are so many club also will hold a 6-week training session are mapping the sex chromosome X and chro­ different scientific interests in the human for new members on the South River in mosome 17. "We collect DNA from patients genome, whether it's about disease causation August and September. who come inco our clinic for genetic resting,'' or variation in human populations." Applications for club membership are avail­ says Ledbetter. "So each sample is from a dif­ Schlessinger and his group keep copies of able at the R&W Activities Desk; sign-up ferent and unrelated person. Our cell culcure the X chromosome region they are studying in begins July 25 and ends on Aug. 8. You must collection contains a number of different hybrid cell cultures in their laboratory. "The be an R&W member co join. D human genomes." identity of the donor is locked away," he says. Defective genes responsible for a type of "We know ic's a male, but otherwise that Male Volunteers Wanted neurofibromacosis and chat play a role in some individual is the generic equivalent of the NIMH seeks recovering male alcoholic forms of cancer are located on chromosome 17. unknown soldier. "D volunteers. Please call 496-6981 or Hemophilia and Duchenne muscular dystrophy 496-2141. □ p~ge 8 TheRecord July 24, 1990

GUIDELINES lS-page document that is scheduled to be distributed this week to every NIH lab (Continued from Page 1 ) through its scientific director's office. About 8,000 copies of G11ideli11es were printed. intended to encourage the free exchange ·of "After reading che other documents, which information, protect privileged information, ranged from very brief co rather long, the facilitate scientific investigation and enhance committee agreed on about six to eight topics the professional training of fellows. They that we would cover in our own middle length provide goals cowards which scientists might draft," said Schechter. "We have tried to strive." make it encouraging and supportive co veteran Begun abour a year ago by the late Dr. scientists as well as young researchers new to John Eberhart, compilation of the guidelines the bench or co NJH. was reassigned after Eberhart's

First Dentist Scientist Awardees Visit NIDR

Members of the first graduating class of the new Dentist Scientist Award program sponsored by the National Institute of Deneal Research visited the institute recently co report on their experiences in the 5-year pro­ gram. Through the new program, the insti­ tute supports students with dental degrees as they work wward their doctorates and gain valuable clinical and basic research experience. The 2-day visit co NIDR allowed awardees to meet with each other and some of the top researchers in the field. On the first day, grad­ uates presented their research to dental The first dentist scientist awardees ,neet-with NIDR director Dr. Harald Life (seated, 4rh fro,n I) and his scientists and discussed their personal experi­ deputy director, Dr. Preston A. Littleton Jr. (seated, 2nd from I). ences in the program. The following day, awardees were invited tO attend and cake part that never would have opened before." horizons. "The DSA has greatly increased the in a meeting of the insticute's National "The Dentist Scientist Award is rhe pre­ caliber of research I was personally able co Advisory Dental Research Council-the scien­ miere program for training future dental do," said Mallery. "You can present your own tific body that makes final recommendations researchers," said NIDR director Dr. Harald ideas and work on your own projects as on NJDR grant awards and considers policy Loe. "By supporting doctoral training and opposed to working wirh Ph.D.'s who have issues related to the support of dental research. research protocols for these demists we are already established what you need co do for "The Dentist Scientist Award allowed me to ensuring that there wiU be enough dental sci­ chem." create my own job description and become the entists capable of moving from basic to Says Mallery, "It's really given me a great expert that 1 think NIDR envisioned­ clinical research in the 21st century." deal of freedom. Being awarded the DSA was clinician, teacher and researcher," said Dr. Dr. Susan Mallery, a Ph.D. candidate in an overwhelmingly positive experience." Martha Ann Keels, a Ph.D. candidate at the experimental pathology at Ohio State, says she The NIDR plans to follow the careers of the University of North Carolina. Keels, who spe­ never thought about research while she was in graduates for the next 10 years co see if the cializes in the epidemiology of craniofacial dental school. Bue after a year and a half in goal of increasing rhe number of dentists in birth defects, says, "Doors have opened for me general practice she decided co expand her research is being fulfilled. 0

NICHD Holds Awards Ceremony Fauci Receives Honorary Degrees Dr. Duane Alexander, direccor of the Dr. Anthony S. Fauci, director of NJAID, National Institute of Child Health and recently received honorary degrees from four Human Development, recently honored educational institutions. The degree of doctor NICHD employees at the Director's Award of science, honoris causa, was conferred on Ceremony. Sponsored by the institute's equal him during graduation ceremonies at Mount employment opportunity committee, the cere­ Sinai Medical Center, New York City; mony recognizes outstanding accomplishments Georgetown University school of medicine; and achievements by employees in carrying Neumann College, Ascon, Pa; and our the mission of NICHD. Hahnemann University, Philadelphia, where Equal Employment Special Achievement he also delivered the. commencement address Awards were presented co Dr. Douglas E. to the graduate school and school of medicine. Father Leo O'Donovan, SJ. ·(/), president of Brenneman, Dr. Leslie D.C. Cooper, Dr. In addition, he delivered the commencement Georgetown Uni11ersity, confers a doctor ofscience David B. Gray and Baldwin M. Wong. address to the Harvard Medical School class of degree, honoris causa, to NIAID director Dr. Receiving Merit Awards were Dr. Scott F. 1990. Anthony S. Fauci. Three other schools honored Andres, Hallie K. Boone, Richard Green­ Fauci was honored for his many contribu­ Fauci at com,nencements last spring. awalt, Catherine A. O'Connor, Michael H. tions to understanding the function of the Rosenthal and Lydia C. Yuan. human immune system and the pathogenesis cantly, he developed effective therapies· for PHS Commendation Medals were presented and treatment of immune-mediated diseases. formerly fatal diseases such as polyarteritis co Drs. Jose G. Rigau and Leslie D.C. He is recognized worldwide for his current nodosa, Wegener's granulomacosis, and lym­ Cooper. Drs. Ephraim Y. Levin and William research on HIV infection and AIDS. He has phomacoid graoulomatosis. S. Stokes received PHS Citations. delineated the immunopathogenic mechanisms As chief, Laboratory of Immunoregulation, Quality Step Increases were awarded to of HIV infection and has been instrumental in NIAID, a position he has held since 1980, Mary Ellen Colvin, Sandra Fitzgerald, Linda developing strategies for the therapy and Fauci continues his basic and clinical research · Frew, Richard Greenawalt, Martha Guice, immune reconstitution of patients with AIDS. on rhe immune system and continues to rrain Belinda Jackson, Dr. Eric Lee, Sandra Ott, In rhe 1970's, Fauci firsr became interna­ postdoctoral fellows. Fernande Rakes, Rosemary Riggs, Arline tionally recognized for his basic research in In 1987, Fauci received an honorary degree Sanchez, Sieghild Sloan, Genevieve Sotak, human immunology as well as for srudies on from his alma mater, Holy Cross College in Shirley Sutphin, Dr. Richard Tasca, Diane disorders of the immune system. Mose signifi- Worcester, Mass. D Wetherill and Evelyn Witt. D page 10 The Record July 24, 1990

New Bulletin Board System Developed by DCRT DRG Ties Into BBS System

The Computer Center is now offering a new files available for downloading co personaJ The Division of Research Grants electronic NIH Centralized BuUecin Board System computers. These three components (con­ bulletin board is now available for use by NIH (BBS). Does your group, office, or organiza­ ferences, bulletins, and files) all relate co the employees and ochers with valid DCRT tion need to discuss AIDS research, lab "topic" of the bulletin board. How the three account numbers. le can be accessed by log­ techniques, scheduling problems, or ocher components of a bulletin board are used is ging on to WYLBUR and typing the professional interests with your peers- world under che complete control of the individual command ENTER BBS. Select ORGLINE as wide? Do you need co publish public notices, who is che moderator of the board. This the board you wish to enter and follow the agendas, seminar proceedings, safety proce­ person escablishes the overall topic of rhe indi­ instructions and prompts given by the pro­ dures, or parent announcements? Do you need vidual bulletin board and che "subtopics" of gram to locate the information of interest co co share and access information about grams ics various components. you. guidelines, meeting schedules, housing avail­ ENTER BBS makes many bulletin boards DRGLINE (NIH GRANT LINE) is part of ability, or computers at NIH? Anyone can use (about a variety of topics) available with a the NIH Bulletin Board System chat was ENTER BBS co access a variety of bullerin single telephone call and logon. To reach these announced in the July issue of Interface. For boards or co create and be the moderator of an bulletin boards, simply use a personal com­ users in the extramural research community, electronic bulletin board of their own. puter or terminal co logon to WYLBUR, then the bulletin board is known as the NJH The design of ENTER BBS was a collabora­ type ENTER BBS. You will then obtain a list GRANT LINE. lt consists of bulletins, files, tive effort of the NIH Computer Utility and of che bulletin boards ava.ilable and will be and an opportunity to make comments for use che Computer Center staff. Potential users of able to choose the one chat seems mosc inter­ in evaluation of chis method of disseminating ENTER BBS were used as resr evaluators esting. Switching co other bulletin boards NIH extramural program information to the during its design phase. without exiting the ENTER BBS facility is research community. ENTER BBS is not a bulletin board; ic is a quite simple. Best of all, each bulletin board This new electronic information service can second generation bulletin board system chat uses the same command syntax and help be used to download wcekJy issues of the NIH provides a collection of independent boards, facility. Since ENTER BBS is an integrated Guide for Grants and Contram, the latest created by any Computer Utility user. One system, it is not necessary to learn different revisions of program announcements and does not have co be a "computer professional" commands and procedures for accessing guidelines, the extramural green pages (abbre­ co sec up, run, or access an electronic bulletin multiple bulletin boards. viated NJH Telephone Directory), and ocher board. No special equipment is required. Even though ENTER BBS is easy to learn items such as monthly or quarterly indexes co Wich ENTER BBS, you onJy need co have a just by using it, the Computer Center has the NIH Guide. For more information about desire co communicate. announced a series of overview seminars. For DRGLINE, try signing on co the NIH Each bulletin board within the system can individual assistance or to request a presenta­ Bulletin Board Sysrem--or send a message provide electronic conferencing, direct display tion for your own group, contact the Training via WYLBUR mail co JQJ. 0 of online information, and notices, as well as Unit, 496-2339. 0

Carcinoma Conference Planned

The National Cancer Institute, the National lnsticuce of Allergy and Infectious Diseases, and the National lnsricuce of Diabetes and Digestive and Kidney Diseases are sponsoring a conference on "Hepacocellular Carcinoma in North America, " which will be held Sept. 26 an.d 27 in the Lister Hill Auditorium, Bldg. 38A. The purpose of chis conference is co d.e.fine che scientific questions concerning hepacocellu­ lar carcinoma as ic occurs in North American patients and co collect and publish data from studies of these patients. The program will cover epidemiology, etiology (viral and chemi­ cal), pathogenesis, diagnosis and screening, and therapy. Searing will be limited; chose interested in attending are encouraged co reg­ ister now. Four new members were recently appointed to 4-year temu on the National AdviJory Allergy and InfectiotlJ For further information concaet conference Diseases Co11ncil. Shrnvn with NIAID director Dr. Anthony Fa11ci (I), they are (from/) Dr. J. Wayne consultant Beery Rollins, Crosspachs Manage­ Streilein, professor and chairman of the departl!lent of microbiology and immunology at the University of ment Systems, Inc., telephone: Miami school of medicine; Dr. Janet L. Mitchell, director of perinatology at Harlem Hospital Center in l-800-527-2847. 0 New York; Dr. Arnold S. Manto, profeuor of epidemiology and international health at the University of Michigan Hhool ofp11blic hea/Jh; and Dr. Lawrence M. Lichtenstein. director of the j ohns Hopki,u Asthma and Allergy Center. page 11 The Record July 24, 1990

Calvin Waddell Retires After 40 Years in Government =TRAINING TIPS The N IH Training Center of the Division Calvin Waddell, a computer clerk in rhe of Personnel Management offers the following: NIGMS Office of Dara Management, retired recently after 40 years of government service, Starting 23 of them at NIGMS. Courses and Pro1vams DateJ During chose years, Waddell witnessed tre­ Management and S11perviJory 496-6371 mendous growth and change in the insriruce. Recognition Secrets: Innovations NIGMS data management officer Thomas for Rewarding Today's Workers 9/9 Mitchell said, "You might say that NIGMS Managing Srrc-ss, Maximizing grew up around Mr. Waddell." Effectiveness 9/ I I Effewvc Communications 9/ 11 Waddell began his government career in Managing Oumanding Performers 9/20 1943 as a messenger with the Government Hands-On Animal Techniques Accounting Office. He was only 16 when he Workshop: Rodent Techniqlles 9/26 scarred his service, bur World War II was in Office Operatiom Training 496-62 l l progress, and it was an opportunity for him co work while attending high school at night. Delegated Acquisition 8/20 Basic Time and Anendance 8/2 He recalled char at chat rime, "government lnrrodunion ro Working at NIH employees worked a 5 '/,-day week." for New Support Scaff 8113 In 1950, he spent the year with the U.S. Calvin Waddell is co11grat11lated 011 his 40 years of Census Bureau. From 1951 co 1960, Waddell Per.ronal Computer Training 496-6211 government service by Dr. R11th L. Kirschstein, was a clerk with the Federal Aviation Agency. NIGMS director. Advanced Microsoft Word 8/1 During the following 2 years, he worked in Mac Draw II 8/2 the Department of the Navy, the U.S. Marine Introduction to CrickctGraph 8/3 Improving Keyboarding Skills 8/3 Corps, and rhe U.S. Postal Service. Harvard Graphics 8/6 In 1962, Waddell decided ro leave rhe gov­ A native Washingtonian, he devoted his Welcome rn Macimosh 8/6 ernment and worked ar a variety of jobs in adult life co caring for his handicapped Excel Level 2 819 private industry. He returned, however, in brother, Richard, who passed away several Advanced WordPerfect (Macintosh) 8110 Introduction ro Power Poinc 8/13 1967 and was hired by NIH as a nursing months ago. Although from a family of eight Hypercard 8114 assistant in the Clinical Center for what was siblings, Waddell has only cwo sisters and rwo 3Com Necwork Administrator 8115 then the National Institute of Arrhriris and brothers remaining, bur he also has "abouc 40 Welcome to Macintosh 8120 Metabolic Diseases. nieces and nephews." Locus 1-2-3 Advanced Topics 8/27 Intro to WordPerfect 5.0 9/1 I The following year, Waddell joined NIGMS Waddell takes great pride in the home that Word Perfect 5.0 Advanced Topics 9/17 as a clerk in the Administrative Office. He bas he purchased in Washington, where he plans Intro to dBasc Ill Plus 9/ 18 been in rhe NIGMS Office of Dara Manage­ co spend his retirement working with senior cicizens.-Wanda WarddeU T,·ai11i11g and Dewlopment Services 496-6211 ment since 1971. D Personal Computer craining is available through User Resources Cenrer (URC) self Study courses. There is no cost to NIH employees for these hands-on sessions. The VRC hours are: DCRT Summer Term in Computer Training Under Way Mon .-Thurs. 8:30 a,m. - 7 p.m, Friday 8:30 a.m. - 4:30 p.m. The summer term of the OCRT Computer senced by Dr. Ralph Nossa!, Physical Sciences 9 a.m. - I p.m. Satu.rday Training Program is well under way. A num­ Laboratory, DCRT . Training Center, DCRT, and ocher training ber of new courses and seminars of inreresr ro The summer program also offers experienced information is available on WYLBUR. Logon scientists will be offered in August. As users of the IBM 370 mainframe a rare oppor­ ro WYLBUR and type ENTER TRAINING always, there is no charge co students or their tunity co delve into the complexities of Job organizations. Control Language. A senior computer special­ New offerings in UNIX include "Editing ist will present "Advanced JCL at NIH" New, Used Uniforms Sought with Emacs" on Aug. 7 and "Advanced beginning Aug. 2. Topics covered will include Emacs," Aug. 16-17. Emacs, in addition co how co create and maintain private libraries, The DC Branch , Mcrropolican Arca COA, being the most popular screen-oriented editor how co identify and correct JCL errors, and Inc. is operating a Uniform Service Center ro on UNIX systems, is also a complete and how co create catalogued procedures. provide for the sale of new and high-quality integrated environment including facilities for The summer 1990 program includes 35 used PHS uniforms and uniform-related programming, mail, network access and docu­ seminars and courses on copies ranging from apparel items. Officers are encouraged ro ment processing, electronic mail co personal computing. To donate or consign surplus uniform items to On J uly 30, a seminar on "Object Oriented sign up for a course or seminar, call the Com­ rhe center. To dace, chis activity has generaced Programming with C + +" will offer an over­ puter Center Training Unit, 496-2339. Copies $1,200. All proceeds are contribuced co a view of che language features of C + + char of the summer 1990 computer training courses charitable organization. This year monies were support object oriented programming. and seminars brochure describing all of che given co the Children's Inn at NIH. The pro­ Biophysicists and cell biologists interested offerings and listing their dares, times and gram is temporarily housed in the Parklawn in problems relating co cell motility may be locations are available from the Computer Bldg., Rm. 7 A32, until appropriate space can interested in attending a brief seminar, Center's Technical Information Office, Bldg. be identified. For further information, contact "Analyzing the Viscoelastic Properties of 12A, Rm. 1015, 496-543L. 0 Capt. Amy Barkin, 443-8113. D Cytoplasm" on Aug. 2, which will be pre- page 12 The Record July 24, 1990

Year 2000 and Beyond lot. Another person stated that parking for contractors was equally difficult and, with all CC Staff Learns Options for Future of Bldg. 10 this new renovation coming up, what could be done to plan for this chaos? By Anne Barber Williams scared that these and ocher significant problems could be worked through The cornerstone for Bldg. 10 was laid in new pipes in the building to provide chilled by communications between employees and 1951 and throughout the years, NIH's warer, hood vents, and, above all, the engineering staff and adequate planning to Division of Engineering Services has electrical capacity in general is insufficient. minimize rhe impact of a major construction maintained, repaired, and added onto the "We are at a stage where patches and effort. "There will be a workforce of between existing facility without replacing the original bandaids can no longer do ir. When we get 200-300 workers when construction starts," he utilities such as air conditioning, electrical into the fixtures, we have co get into the related. wiring and pipes. services provided. lt is not a simple matter. In response ro a question about where we On June 28, Dr. William F. Raub, acting Correction of these deficiences will require a stand now, Raub answered, "We are in the NIH director; George Williams, acting major construction effort in several phases." earliest stages of planning. No binding deputy director, DES; John Jenkins from Raub continued, "But first, we must decision has been made ocher than we have to DES's Facilities Engineering Branch; and identify where we will provide turnaround do ir--even as painful as ir is going to be. representatives from three architectural/ room. Logistically, it is a nightmare. Utilities Sometime within the next few months, the consulting firms that have been working on are oriented vertically with programs oriented renovation alternative should be determined." Bldg. lO's infrastructure modernization and horizontally. We hope to limit relocations, It was pointed out by one of the architects improvement program held an informal but out of necessity, everyone will need to that while we are looking to build something discussion on the renovation of Bldg. 10. relocate ac lease once and, hopefully, nor more that will last long into chc future, there is no In introducing the panel, Raub had chis to than twice, but don't read my lips. way you can design a building chat will be say about the private firms, "They have "The entire Building 10 renovation is responsive ro all needs. Flexibility within the designed similar things-nor identical­ expected to cake 10 to 15 years. At the end of facility system wi ll be the key in meeting because there is nothing like Building 10. rhis long term, the research opportunities will future requirements. "NIH is still number one in the biomedical he different, che patient care will be different Questions were asked about the Bldg. 10 sciences. And if we are to continue to be first, and hospital services will be different. Our clinic tower (formerly the ACRF), which now chose of us in management and administration planning process needs to respond ro these has functional and technical problems. Raub's muse attend co many things- salaries, changes. response: "You are right. When Building lO's parking, safety and maintenance of the "Looking ahead we have multiple points of renovations are over, rhe next step is the buildings we occupy. view. Built-in flexibility will be the key and ACRF. We need co look not only at solving "The Clinical Center is central to che even more cri cical in the oext century to these problems bur also ar anticipating the intramural programs and what NIH stands for respond to future needs. Mosely, we muse ones coming up. to such an extent chat, if we ignore its needs preserve rhe beauty and research of the campus In summation, Raub stated, "We are intent we literally risk the future. We must face up as always." on keeping NIH as the best and co keeping to and deal with its problems. Williams explained, "To renovate a chis building functioning the way it should ." "The Clinical Center was builc in the complex this large presents a lot of problems. The final decisions about Bldg. 10 will be 1950's, with the needs and expectations of We will need to vacate to larger space by made by a steering committee chaired by chat time. le is remarkable how it has stood renting, buying, or conscruccing new space to Raub that includes the following members: with all the advances made in biomedical yield sufficient space to start construction. We Dr. Vida Beaven, NIH assistant director for sciences. It was one of the first centrally air will use an approach similar co the round program coordination; Dr. Saul Rosen, acting conditioned hospitals. However," Raub robin renovations taking place. We will need director, Clinical Center; Dr. Cherie Fisk, continued, "by most measures, chis is not a to identify areas that we could expand, if new special assistant for scientific activities, ORS; hospital. It is a laboratory with a hospital construction is part of any solution. Thus far, Norman Mansfield, director, ORS; Dr. around it. the answer seems to be south, west, and Richard Wyatt, assistant director for "Changes in the populations within the northwest of the building. This is a terribly intramural affairs, OD; Dr. Joseph Rall, NIH building and all the increasing demands bring massive and complex project that causes us a deputy direccor for intramural research; Tony about necessary concerns for safety and health. lot of concern and demands close incegracion Clifford, acring director, DES; Williams; For instance, there is asbestos in places where of programs, utility aod logistical needs." Jenkins; Mike Harrison, DES and Cheryl we rather it not be, along with biohazards ln response co a question regarding the Amarucci, DES. D (viruses) and toxic hazards from chemical and possibility of separating the Jabs from the molecular biological srudies. We need proper clinic and hospital, Williams sa.id, "We would conduits for the hood exhausts. not divorce labs that have critical ries with rhe "We still have in use the original central hospital area. The decision to move those NICHD's Love Tape Honored system in these buildings. It is a credit to the activities off campus will be determined by eogineers that they have continued to keep it economics and the need to remain in close Marsha Love of NICHD's Office of Research going and to the original designers of the proximity to rhe patient care units. This is a Reporting recently won the Silver Screen building. There is , however, potential. for a critical issue and the steering committee will (second place) award from the United Scates catastrophe-where part of the building would make che decision." Festivals Association film and video competi­ have to be closed down, or worse, someone Parking continues co be a major problem of tion for her videorape "Prenatal Care: A would get hurt. concern co employees all across campus. So Window of Opportunity." The same videotape "There was a scudy done in 1988 char much chat, in fact, one employee asked if rhey also won honorable mention from rhe Associa­ estimated ir would cost between $400-800 had considered building a new hospital and tion for the Care of Children's Health. D million ro renovate Building 10. We need gutting Building 10 and building a parking U.S. GOVERNMENT PRINTING OFFICE 1989 201 769/000022