Yearbook 2004 Yearbook 2004
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
All'ombra Delle Querce Di Monte Sole
UNIVERSITA’ DEGLI STUDI DI FERRARA FACOLTA’ DI LETTERE E FILOSOFIA Corso di laurea in Filosofia ALL’OMBRA DELLE QUERCE DI MONTE SOLE riflessioni sulla kenosi del monaco Giuseppe Dossetti al cospetto della storia e del mistero di Israele laureando Giambattista Zampieri relatore correlatore prof. Piero Stefani prof. Mario Miegge Anno Accademico 2006-2007 Indice INTRODUZIONE AL COSPETTO DELLA STORIA p. 1 Premessa 1 Vita 5 Piano di lavoro 25 CAPITOLO I DA MONTE SOLE A SIGHET (l’idolatria e la città) 29 Le querce testimoni del martirio 30 La Shoah come unicum 34 Un delitto castale 41 Gemeinschaft e città 49 CAPITOLO II IL MISTERO DI ISRAELE (il silenzio e l’elezione) 67 Dopo Auschwitz, dopo Cristo 68 Chi è come Te fra i muti? 73 Scrutando il mistero della Chiesa 78 L’impossibile antisemitismo 94 L’elezione del popolo mediatore 102 CAPITOLO III LA KENOSI DEL MEDIATORE (la croce e la Chiesa) 128 Questo è Dio 129 Fino alla morte e alla morte di croce 140 La kenosi della Chiesa 148 Già e non ancora: un confronto con Sergio Quinzio 157 CONCLUSIONE L’OMBRA DELLE QUERCE 175 Memoria sapienziale 176 L’azione preveniente dello Spirito 182 BIBLIOGRAFIA 187 Scritti e discorsi di Giuseppe Dossetti (ordine cronologico) 187 Nota bibliografica (ordine alfabetico per autore) 199 INTRODUZIONE AL COSPETTO DELLA STORIA Premessa Questo lavoro si propone di enucleare alcuni aspetti del pensiero sviluppato da Giuseppe Dossetti soprattutto nella seconda parte della sua esistenza, quando assecondò l’improcrastinabile chiamata a realizzare nella vita monastica quanto sentiva impellente già dagli anni giovanili. Nel 1939 scriveva: “In che cosa la mia vita si caratterizza per quella di un’anima consacrata al Signore, più precisamente consacrata a Cristo Re, nel mondo? Per il fatto che scrivo così dei libri? No, certo. -
Frank Press 1924–2020
perspectives KEN FULTON AND MARCIA MCNUTT Remembering Frank Press 1924–2020 Frank Press, portrait by Jon Friedman, 1995 rogress in the authoritative use of scientific evidence Press was born on December 4, 1924, and grew up in New to guide wise government policy is a story of people, York City, the son of Russian Jewish immigrants. He recalled ideas, and institutions. As an example, Frank Press being a poorly performing student in the public school Plaunched Issues in Science and Technology as a vehicle to system until sixth grade, when a pair of glasses allowed him provide a forum in which a community of experts could to read the blackboard. Early on, he developed an interest share their experiences, opinions, and proposals for in science from reading periodicals such as Popular Science advancing science in the public interest under the banner and Popular Mechanics, but it was a high school geology of a trusted, nonpartisan science policy institution. It is teacher who ignited his interest in the geosciences. While therefore most fitting that we highlight here Press’s many conducting an assigned magnetic survey of Van Cortland contributions to science policy through his ideas and the Park in the Bronx, he realized that with geophysics he could institutions he built. apply his aptitude for physics to explore the unknown. 20 ISSUES IN SCIENCE AND TECHNOLOGY perspectives Press completed a physics major at City College of New excitation of Earth’s free oscillations for the very first time, York in 1944 in just two and a half years, studying year- thus deriving new information about the structure of Earth’s round as was common during the war years. -
UNESCO Kalinga Prize Winner - 1999 Prof
Glossary on Kalinga Prize Laureates UNESCO Kalinga Prize Winner - 1999 Prof. Marian EWURAMA ADDY An Eminent Bio-Chemist & Science Popularizer from Ghana [Born : Marian Cole, February 7, 1942... ] Public Understanding of Science is crucial for development. If people do not understand science, they may not accept its product. ...Prof. Marian Addy Science is buit of facts the way a house is built of bricks; but an accumulation of facts is no more science than a Pile of bricks is a house. ...Henri Poincare / Marian Addy Scientists are made, not born. ...Marian Addy 1 Glossary on Kalinga Prize Laureates KALINGA PRIZE FOR THE POPULARIZATION OF SCIENCE A Brief Profile of Prof. Marian Addy The 1999 Kalinga Prize for the Popularization of Science was awarded ex aequo to Professors Marian Ewurama Addy from Ghana and Emil Gabrielian from Armenia at a ceremony organized in UNESCO’s Paris Headquarters in November 1999. Professor Marian Addy (born 1942) is Professor to study science and helping the general public to of Biochemistry at the University of Ghana, where accept and understand science. The questions are she specializes in teaching and researching the designed to be of relevance to people’s daily lives. clinical aspects of biochemistry. Among other The programme is sponsored by industry. In research projects, she has led the departmental recognition of her accomplishments in ‘marketing’ research group on medicinal plants and is currenly science to the public, the Chartered Institute of using the hepatic isozyme induced by pollutants Marketing in Ghana nominated Professor Addy as a means of monitoring pollution in the aquatic ‘Marketing Woman of the Year’ in 1995, a departure environment. -
The Royal Society Medals and Awards
The Royal Society Medals and Awards Table of contents Overview and timeline – Page 1 Eligibility – Page 2 Medals open for nominations – Page 8 Nomination process – Page 9 Guidance notes for submitting nominations – Page 10 Enquiries – Page 20 Overview The Royal Society has a broad range of medals including the Premier Awards, subject specific awards and medals celebrating the communication and promotion of science. All of these are awarded to recognise and celebrate excellence in science. The following document provides guidance on the timeline and eligibility criteria for the awards, the nomination process and our online nomination system Flexi-Grant. Timeline • Call for nominations opens 30 November 2020 • Call for nominations closes on 15 February 2021 • Royal Society contacts suggested referees from February to March if required. • Premier Awards, Physical and Biological Committees shortlist and seek independent referees from March to May • All other Committees score and recommend winners to the Premier Awards Committee by April • Premier Awards, Physical and Biological Committees score shortlisted nominations, review recommended winners from other Committees and recommend final winners of all awards by June • Council reviews and approves winners from Committees in July • Winners announced by August Eligibility Full details of eligibility can be found in the table. Nominees cannot be members of the Royal Society Council, Premier Awards Committee, or selection Committees overseeing the medal in question. More information about the selection committees for individual medals can be found in the table below. If the award is externally funded, nominees cannot be employed by the organisation funding the medal. Self-nominations are not accepted. -
[ 1980 ] Appendices
Roster of the United Nations 1347 Appendix I Roster of the United Nations (As at 31 December 1980) DATE OF DATE OF DATE OF MEMBER ADMISSION MEMBER ADMISSION MEMBER ADMISSION Afghanistan 19 Nov. 1946 Greece 25 Oct. 1945 Poland 24 Oct. 1945 Albania 14 Dec. 1955 Grenada 17 Sep. 1974 Portugal 14 Dec. 1955 Algeria 8 Oct. 1962 Guatemala 21 Nov. 1945 Qatar 21 Sep. 1971 Angola 1 Dec. 1976 Guinea 12 Dec. 1958 Romania 14 Dec. 1955 Argentina 24 Oct. 1945 Guinea-Bissau 17 Sep. 1974 Rwanda 18 Sep. 1962 Australia 1 Nov. 1945 Guyana 20 Sep. 1966 Saint Lucia 18 Sep. 1979 Austria 14 Dec. 1955 Haiti 24 Oct. 1945 Saint Vincent and Bahamas 18 Sep. 1973 Honduras 17 Dec. 1945 the Grenadines 16 Sep. 1980 Bahrain 21 Sep. 1971 Hungary 14 Dec. 1955 Samoa 15 Dec. 1976 Bangladesh 17 Sep. 1974 Iceland 19 Nov. 1946 Sao Tome and Barbados 9 Dec. 1966 India 30 Oct. 1945 Principe 16 Sep. 1975 Belgium 27 Dec. 1945 Indonesia2 28 Sep. 1950 Saudi Arabia 24 Oct. 1945 Benin 20 Sep. 1960 Iran 24 Oct. 1945 Senegal 28 Sep. 1960 Bhutan 21 Sep. 1971 Iraq 21 Dec. 1945 Seychelles 21 Sep. 1976 Bolivia 14 Nov. 1945 Ireland 14 Dec. 1955 Sierra Leone 27 Sep. 1961 Botswana 17 Oct. 1966 Israel 11 May 1949 Singapore3 21 Sep. 1965 Brazil 24 Oct. 1945 Italy 14 Dec. 1955 Solomon Islands 19 Sep. 1978 Bulgaria 14 Dec. 1955 Ivory Coast 20 Sep. 1960 Somalia 20 Sep. 1960 Burma 19 Apr. 1948 Jamaica 18 Sep. 1962 South Africa 7 Nov. -
Hans Urs Von Balthasar - Ein Grosser Churer Diözesan SCHRIFTENREIHE DER THEOLOGISCHEN HOCHSCHULE CHUR
Peter HENR1c1 (Hrsg.) Hans Urs von Balthasar - ein grosser Churer Diözesan SCHRIFTENREIHE DER THEOLOGISCHEN HOCHSCHULE CHUR Im Auftragder Theologischen Hochschule Chur herausgegeben von Michael DURST und Michael FIEGER Band7 Peter HENRICI (Hrsg.) Hans Urs von Balthasar - ein grosser Churer Diözesan Mit Beiträgen von Urban FINK Alois M. HAAS Peter HENRICI KurtKocH ManfredLOCHBRUNNER sowie einer Botschaft von Papst BENEDIKT XVI. AcademicPress Fribourg BibliografischeInformation Der Deutschen Bibliothek Die Deutsche Bibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; detaillierte bibliografischeDaten sind im Internetüber http://dnb.ddb.de abrufbar. Die Druckvorlagen der Textseiten wurden vom Herausgeber der Reihe als PDF-Datei zur Verfügunggestellt. © 2006 by Academic Press Fribourg / Paulusverlag Freiburg Schweiz Herstellung: Paulusdruckerei Freiburg Schweiz ISBN-13: 978-3-7278-1542-3 ISBN-10: 3-7278-1542-6 Inhaltsverzeichnis Vorwort . 7 Abkürzungsverzeichnis . 9 Bischof Kurt KOCH Von der Schönheit Gottes Zeugnis geben . 11 Alois M. HAAS Evangelisierung der Kultur . 19 Weihbischof Peter HENRICI Das Gleiche auf zwei Wegen: Karl Rahner und Hans Urs von Balthasar . 39 Manfred LOCHBRUNNER Hans Urs von Balthasar und seine Verbindung mit dem Bistum Chur . 55 Urban FINK „Ihr stets im Herrn ergebener Hans Balthasar“. Hans Urs von Balthasar und der Basler Bischof Franziskus von Streng . 93 Botschaft von Papst BENEDIKT XVI. an die Teilnehmer der Internationalen Tagung in Rom (Lateran-Universität) anlässlich des 100. Geburtstages des Schweizer Theologen Hans Urs von Balthasar . 131 Die Autoren . 135 5 Vorwort Hans Urs VON BALTHASAR ist wohl der weltweit bekannteste katholische Theologe der Deutschschweiz im 20. Jahrhundert. Dass der gebürtige Luzerner und „Basler Theologe“ Churer Diözesanpriester war, ist weit weniger bekannt. Sein 100. -
Five Great Ideas of Biology
GREATGREAT IDEASIDEAS OFOF BIOLOGYBIOLOGY Paul Nurse KITP Public Lecture, Feb 24, 2010 THETHE CELLCELL The basic unit of life ROBERTROBERT HOOKEHOOKE’’SS MICROSCOPEMICROSCOPE Cork Image: Past Present STEMSTEM IMAGES:IMAGES: PASTPAST ANDAND PRESENTPRESENT Nehemiah Grew (1682) ANTONIANTONI VANVAN LEEUWENHOEKLEEUWENHOEK MICROORGANISMSMICROORGANISMS VANVAN LEEUWENHOEK?LEEUWENHOEK? THEODORTHEODOR SCHWANNSCHWANN “We have seen that all organisms are composed of essentially like parts, namely, of cells.” (1839) RUDOLFRUDOLF VIRCHOWVIRCHOW “Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life.” (1858) CELLCELL Rockefeller Nobel Prize Winners in Cell Biology George E. Palade (1974) Christian de Duve (1974) Albert Claude (1974) Günter Blobel (1999) MAMMALIANMAMMALIAN EMBRYOEMBRYO SPERMSPERM ANDAND EGGEGG THETHE CELLCELL The basic unit of life Underpins all reproduction and development Stem cells THETHE GENEGENE Basis of heredity GREGORGREGOR MENDELMENDEL MENDELMENDEL’’SS GARDENGARDEN PEASPEAS PEASPEAS 1919TH CENTURYCENTURY CHROMOSOMESCHROMOSOMES EDOUARDEDOUARD VANVAN BENEDENBENEDEN’’SS NEMATODENEMATODE CHROMOSOMESCHROMOSOMES PNEUMOCOCCUSPNEUMOCOCCUS Avery, MacLeod and McCarty, Rockefeller University (1944) DNADNA MOLECULEMOLECULE CENTRALCENTRAL DOGMADOGMA THETHE GENEGENE Basis of heredity Genotype to phenotype Implications for what we are EVOLUTIONEVOLUTION BYBY NATURALNATURAL SELECTIONSELECTION Life evolves Mechanism of natural selection ERASMUSERASMUS ANDAND CHARLESCHARLES DARWINDARWIN -
Department of Chemistry
Department of Chemistry In the 2005–2006 academic year, the Department of Chemistry continued its strong programs in undergraduate and graduate education. Currently there are 245 graduate students, 93 postdoctoral researchers, and 92 undergraduate chemistry majors. As of July 1, 2006, the Department faculty will comprise 32 full-time faculty members including 5 assistant, 4 associate, and 23 full professors, one an Institute Professor. In the fall, Professor Joseph P. Sadighi was promoted to associate professor without tenure, effective July 1, 2006; in the spring, Professor Timothy F. Jamison was promoted to associate professor with tenure, also effective July 1, 2006. In September 2005, Professor Arup K. Chakraborty took up a joint senior appointment as the Robert T. Haslam professor of chemical engineering, professor of chemistry, and professor of biological engineering. Professor Chakraborty obtained his PhD in chemical engineering at the University of Delaware. He came to MIT from the University of California at Berkeley, where he served as the Warren and Katherine Schlinger distinguished professor and chair of chemical engineering, and professor of chemistry from 2001 to 2005. Highlights The Department of Chemistry had a wonderful year. On October 2, 2005, we learned that Professor Richard R. Schrock, Frederick G. Keyes professor of chemistry, had won the 2005 Nobel Prize in chemistry for the development of a chemical reaction now used daily in the chemical industry for the efficient and more environmentally friendly production of important pharmaceuticals, fuels, synthetic fibers, and many other products. Schrock Professor Richard R. Schrock speaking at a press shared the prize with Yves Chauvin of the conference at MIT on October 5, 2005. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
National Academy of Sciences July 1, 1979 Officers
NATIONAL ACADEMY OF SCIENCES JULY 1, 1979 OFFICERS Term expires President-PHILIP HANDLER June 30, 1981 Vice-President-SAUNDERS MAC LANE June 30, 1981 Home Secretary-BRYCE CRAWFORD,JR. June 30, 1983 Foreign Secretary-THOMAS F. MALONE June 30, 1982 Treasurer-E. R. PIORE June 30, 1980 Executive Officer Comptroller Robert M. White David Williams COUNCIL Abelson, Philip H. (1981) Markert,C. L. (1980) Berg, Paul (1982) Nierenberg,William A. (1982) Berliner, Robert W. (1981) Piore, E. R. (1980) Bing, R. H. (1980) Ranney, H. M. (1980) Crawford,Bryce, Jr. (1983) Simon, Herbert A. (1981) Friedman, Herbert (1982) Solow, R. M. (1980) Handler, Philip (1981) Thomas, Lewis (1982) Mac Lane, Saunders (1981) Townes, Charles H. (1981) Malone, Thomas F. (1982) Downloaded by guest on September 30, 2021 SECTIONS The Academyis divided into the followingSections, to which membersare assigned at their own choice: (11) Mathematics (31) Engineering (12) Astronomy (32) Applied Biology (13) Physics (33) Applied Physical and (14) Chemistry Mathematical Sciences (15) Geology (41) Medical Genetics Hema- (16) Geophysics tology, and Oncology (21) Biochemistry (42) Medical Physiology, En- (22) Cellularand Develop- docrinology,and Me- mental Biology tabolism (23) Physiological and Phar- (43) Medical Microbiology macologicalSciences and Immunology (24) Neurobiology (51) Anthropology (25) Botany (52) Psychology (26) Genetics (53) Social and Political Sci- (27) Population Biology, Evo- ences lution, and Ecology (54) Economic Sciences In the alphabetical list of members,the numbersin parentheses, followingyear of election, indicate the respective Class and Section of the member. CLASSES The members of Sections are grouped in the following Classes: I. Physical and Mathematical Sciences (Sections 11, 12, 13, 14, 15, 16). -
Presidential Files; Folder: 11/22/77; Container 52
11/22/77 Folder Citation: Collection: Office of Staff Secretary; Series: Presidential Files; Folder: 11/22/77; Container 52 To See Complete Finding Aid: http://www.jimmycarterlibrary.gov/library/findingaids/Staff_Secretary.pdf TIIE PRESIDENT'S SCHEDULE Tuesday - November 22,1977 8:15 Dr. Zbigniew Brz.ezinski The Oval Office . 8:45 .Hr . Frank Moore The Oval Office. 10:00 Medal of Science Awards. (Dr. Frank Press). ·Room 450, EOB. I \ 10:30 Mr. Jody Powell The Oval Office. 11:00 Presentation of Diplomatic Credentials. (Dr. Zbigniew Brzezinski} - The Oval Office. 11:45 Vice President Walter F. Mondale, Admiral Stansfield Turner, and Dr. Zbigniew Brzezinski. The Oval Office. 12:30 Lunch \..,-::_ th Hrs. Rosalynn Carter ·- The Ovctl Office. 2:00 Budget Review Meeting. (Mr. James Mcintyre). ( 2 hrs.) The Cabinet Room. THE WHITE HOUSE WASHINGTON \"~ Date: November 22, 1977 l\ vo\ \'~ MEMORANDUM t)lDifll FOR ACTION: '" FOR INFORMATION: Stu Eizenstat ~t""'"' Frank Moore (Les Francis)~ The Vice President Jack Watson Bob Lipshutz Jim Mcintyre FROM: Rick Hutcheson, Staff Secretary SUBJECT: Adams memo dated 11/22/77 re Response to the Boston Plan and Location of Rail Maintenance Facilit.y in the Northeast Corridor YOUR RESPONSE MUST BE DELIVERED TO THE STAFF SECRETARY BY: TIME: 11:00 AM DAY: Monday DATE: November 28, 1977 ACTION REQUESTED: _x_ Your comments Other: STAFF RESPONSE: __ I concur. __ No comment: Please note other comments below: PLEASE ATTACH THIS COPY TO MATERIAL SUBMITTED. If you have any questions or if you anticipate a delay in submitting the required material, please telephone the Staff Secretary immediately.