MOLECULAR AND CELLULAR BIOLOGY VOLUME 4 - DECEMBER 1984 C NUMBER 12

Aaron J. Shatkin, Editor in Chief(1985) Louis Siminovitch, Editor (1985) Roche Institute of Molecular Biology Hospital for Sick Children Nutley, N.J. Toronto, Canada Harvey F. Lodish, Editor (1986) Paul S. Sypherd, Editor (1985) Whitehead Institute for Biomedical University of California Research Irvine, Calif. Cambridge, Mass. Harold E. Varmus, Editor (1989) David J. L. Luck, Editor (1987) University of California Rockefeller University San Francisco New York, N.Y.

EDITORIAL BOARD Renato Baserga (1985) Ari Helenius (1984) Steven McKnight (1986) Milton J. Schlesinger (1986) Alan Bernstein (1984) Susan A. Henry (1985) Robert L. Metzenberg (1985) Phillip A. Sharp (1985) J. Michael Bishop (1984) Ira Herskowitz (1984) Robert K. Mortimer (1985) Fred Sherman (1985) Joan Brugge (1985) James B. Hicks (1986) Paul Neiman (1986) Anna Marie Skalka (1986) Breck Byers (1985) John A. Carbon (1984) Tony Hunter (1986) Harvey L. Ozer (1985) Pamela Stanley (1985) Lawrence A. Chasin (1985) Larry Kedes (1985) Mary Lou Pardue (1985) Joan A. Steitz (1985) Nam-Hai Chua (1985) Barbara Knowles (1986) Mark Pearson (1985) James L. Van Etten (1985) Terrance G. Cooper (1984) Marilyn Kozak (1985) Jeremy Pickett-Heaps (1985) Jonathan R. Warner (1984) James E. Darnell, Jr. (1985) Monty Krieger (1986) Robert E. Pollack (1985) Robert A. Weinberg (1984) Gary Felsenfeld (1985) Elias Lazarides (1985) Keith R. Porter (1985) I. Bernard Weinstein (1985) Norton B. Gilula (1985) John B. Little (1985) John R. Pringle (1985) Harold Weintraub (1985) James E. Haber (1984) William F. Loomis, Jr. (1985) Daniel B. Rifkin (1985) Reed B. Wickner (1985) Benjamin Hall (1985) Paul T. Magee (1985) Robert G. Roeder (1985) Leslie Wilson (1985) Hidesaburo Hanafusa (1986) James Manley (1986) James E. Rothman (1984) Edward Ziff (1985)

Helen R. Whiteley, Chairman, Publications Board Walter G. Peter III, Director of Publications Linda M. Illig, Managing Editor, Journals Linda M. Illig, Production Editor Molecular and Cellular Biology (ISSN 0270-7306) is devoted to the advancement and dissemination offundamental knowledge concerning the molecular biology of eucaryotic cells, of both microbial and higher organisms. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The journal is published monthly, one volume per year. The nonmember subscription price is $92 per year; single copies are $21. The member subscription price is $27 (foreign $35 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Molecular and Cellular Biology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the United States of America. Copyright © 1984, American Society for Microbiology. Ea* rfr{U4, (III All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the arti- cle may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Adzuma, Kenji, 2735 DePinho, Ronald, 2905 Kruger, Kelly, 2905 Salzman, Norman P., 2911 Ahlquist, Paul, 2876 Diggelmann, Heidi, 2929 Krzywicki, Karen A., 2837 Sanders, Marilyn M., 2676 Alt, Frederick W., 2905 Drummond, Robert J., 2745 Sarokin, Laura, 2750 Andrews, Nancy, 2905 Lai, Bai-Tang, 2802 Schaack, Jerome, 2714 El-Sherbeini, Mohamed, 2818 Lanks, Karl W., 2802 Schloss, Jeffery A., 2686 Baltimore, David, 2905 Evan, G. I., 2587 Lewis, George K., 2843 Sefton, Bartholomew M., 2697, Basi, Guriqbal S., 2828 Evan, Gerard I., 2843 Leys, Eugene J., 2921 2705 Basilico, Claudio, 2925 Liang, T. Jake, 2774 Seidman, Michael, 2610, 2622 Belfort, Marlene, 2858 Farrell-Towt, James, 2676 Liboi, Elio, 2925 Shulman, Marc J., 2565 Benjamin, Thomas L., 2774 Firtel, Richard A., 2890 Longmire, Jonathan L., 2932 Silan, Colleen, 2890 Bishop, J. M., 2587 Forbes, Douglass J., 2580 Lund, Elsebet, 2580 Silflow, Carolyn D., 2686 Bishop, J. Michael, 2843 Frayne, Elizabeth G., 2921 Lutzker, Stuart, 2905 Sive, Hazel L., 2723 Blochlinger, Karen, 2929 SoIl, Dieter, 2714 Blose, Stephen H., 2865 Gorman, Cornelia M., 2622 Macklin, Michael D., 2643 Stallings, Raymond L., 2932 Boardman, Mark, 2828 Gottesman, Michael M., 2639 Magasanik, Boris, 2758, 2767 Stanek, Albert E., 2802 Bostian, Keith A., 2818 Greenwood, Michael T., 2858 Mes-Masson, Anne-Marie, 2594 Stark, Benjamin C., 2643 Bouvier, Montserrat, 2594 Mirdamadi, Behzad, 2858 Stein, Roland, 2792 Brady, John N., 2911 Haguenauer-Tsapis, Rosine, 2668 Mishoe, Helena, 2911 Stillman, Bruce W., 2865 Brandriss, Marjorie C., 2837 Hamada, Hiroshi, 2610, 2622 Mitchell, Aaron P., 2758, 2767 Stollar, B. David, 2610 Brazzell, Cheryl, 2573 Hassell, John A., 2594 Mitchell, Diane J., 2818 Storms, Reginald K., 2858 Burke, Deborah Johnson, 2714 Hawley, Robert G., 2565 Mueller, Christopher R., 2594 Storti, Robert V., 2828 Bums, Daniel K., 2643 Heintz, Nathaniel, 2723 Munk, A. Christine, 2932 Sugino, Akio, 2811 Buss, Janice E., 2697, 2705 Herrick, Glenn, 2661 Symonds, G., 2587 Hildebrand, Carl E., 2932 Nellen, Wolfgang, 2890 Carlson, Marian, 2750 Hinnen, Albert, 2668 Nitiss, John, 2811 Tarpley, W. Gary, 2653 Carmichael, Gordon G., 2774 Hoffman, Eric P., 2883 Tegtmeyer, Peter, 2631 Caruso, Maurizia, 2925 Hook, Amy G., 2921 Ogawa, Hideyuki, 2735 Temin, Howard M., 2653 Chin, Nena W., 2802 Howard, Bruce H., 2622 Ogawa, Tomoko, 2735 Thomas, Barbara, 2714 Chooi, W. Yean, 2643 Hozumi, Nobumichi, 2565 Ord, Robin W., 2858 Tipper, Donald J., 2818 Chow, Terry, 2811 Hunter, Tony, 2705 O'Rourke, Edward C., 2745 Chu, Frederick K., 2858 Hutchison, Keith W., 2899 Cooley, Lynn, 2714 Pastan, Ira, 2639 Vlahakis, George, 2639 Copeland, Neal G., 2899 Ingolia, Thomas D., 2573 Patschinsky, Tilo, 2705 Voronova, Anna F., 2705 Corces, Victor G., 2883 Petrino, Marianne G., 2610 Crawford, Brian D., 2932 Janda, Michael, 2876 Podgorski, Gregory, 2784 Creasey, Abla A., 2745 Jenkins, Nancy A., 2899 Pruitt, Steven C., 2851 White, Eileen, 2865 Crouse, Gray F., 2921 Wright, Peter J., 2631 Kakunaga, Takeo, 2610 Radonovich, Michael, 2911 Dahlberg, James E., 2580 Kamps, Mark P., 2697 Reeder, Ronald H., 2851 Dawson, Dean, 2661 Keh, William, 2802 Resnick, Michael A., 2811 Youngblom, James, 2686 Deering, Reginald A., 2784 Kellems, Rodney E., 2921 Roeder, Robert G., 2723 DeLucia, Angelo L., 2631 Klempnauer, K.-H., 2587 Roth, Charles, 2639 Ziff, Edward B., 2792 ACKNOWLEDGMENT The following have served as invited special reviewers for the joumnal during 1984, and their help is greatly appreciated.

Stuart Aaronson Nicholas Cowan Anita K. Hopper R. B. Needleman Art Skoultchi Bruce G. Adams Elizabeth Craig J. E. Hopper Joseph Nevins Clifford L. Slayman Eileen Adamson Thomas Curran Marshall Horwitz Carol Newlon James Smiley M. Aguet James Dahlberg David Housman Maynard Olson Martin Snider Vincent G. Allfrey Kathleen J. Danna Peter Howley Yasuji Oshima Dieter Soll Frederick Alt Channing Der Richard 0. Hynes Dale Oxender Barbara Sollner-Webb Irene Andrulis Randy Dimond James Ingles Brad Ozanne Patricia Spear Gilbert Ashwell Robert Dottin Gilbert Jay Richard Palmiter Dennis W. Stacey K. D. Atkinson Ian Dube Warren Jelinek Arthur Pardee Frank Stahl Corrado Baglioni Donald Dubin Gerald C. Johnston R. E. Pearlman E. Richard Stanley Andrew L. Ball Gregg Duester Nicholas Jones Thoru Pederson George Stark Amiya K. Banerjee Primal de Lanerolle Grace Ju Hugh R. B. Pelham J. E. Stefano A. Richard Bellamy William C. Earnshaw Robert Kamen D. Perlman Nat Sternberg Robert M. Benbow Robert Edgar Jack Keene P. S. Perlman Rolf Sternglanz Welcome Bender Melanie Ehrlich Rodney E. Kellems Robert Perry Bruce Stillman Thomas Benjamin Robert Elder Robert Kerbel Sidney Pestka Sidney Strickland Patricia E. Berg Sarah Elgin George Khoury Thomas D. Petes Kevin Struhl John Bergmann Ellis Englesberg Marc W. Kirschner Linda Pike Bill Sugden Arnold Berk Raymond Erickson David Knipe Gianni Piperno William C. Summers Kenneth Berns Michael S. Esposito Gunther Kohlhaw Rudi J. Planta Olaf Sundin Barbara Birshtein Steven Farmer Robert Kramer W. J. Pledger P. S. Sunkara Elizabeth Blackburn Ray Fenwick Michael Kuehl Louise Prakash Betsy Sutherland Gunter Blobel James Feramisco Elizabeth Lacy David M. Prescott Jack Szostak H. Boedtker John Fessler Karl G. Lark Carol Prives Widmar Tanner David Boettiger John R. S. Fincham Ronald A. Laskey Cary Queen Linda S. Thomashow Dan Bogenhagen Gerald R. Fink Robert Lazzarini Uttam RajBhandary Larry Thompson Lawrence Bogorad David B. Finkelstein I. R. Lehman Peter Ray Jeremy W. Thorner K. A. Bostian Donald A. Fischman Michael J. Leibowitz Charles Redding Shirley M. Tilghman Michael R. Botchan Richard B. Flavell Ihor Lemiska Steven Reed William E. Timberlake David Botstein Jane Flint Peter Lengyel Ronald H. Reeder Donald Tipper Martin Breitman Wayne Flintoff Robert L. Lester M. A. Resnick Robert Tjian B. R. Brinkley Victoria Foe Wallace Le Strougeon Alexander Rich William Topp J. R. Broach William A. Fonzi Arnold Levine Richard Rifkind Chris Town Leon W. Browder Gordon Foulkes Myron Levine Jack Riordan Jocinda A. Traugh Donald D. Brown Thomas Fox Susan Lindquist Phillips W. Robbins Lap-Chee Tsui Jeremy Bruenn D. W. Francis Vic Ling Larry Rohrschneider B.-K. Tye Karen J. Brunke Bill Frazier Peter Linsley Bernard Roizman Buddy Ullman Manuel Buchwald Errol Freidberg David Livingstone Ora M. Rosen Richard B. Vallee Howard Bussey E. Gattlub Peter Lomedico Joel L. Rosenbaum Harold E. Varmus Ronald Butow Malcolm Gefter Joseph J. Maio Naomi E. Rosenberg Inder Verma Katharine Calame Ray Gesteland Robert E. Malone Russell Ross Sam Wadsworth Judith L. Campbell Mary Jane Gething Thomas Maniatis John R. Roth Geoff Wahl Mario R. Capecchi Nicholas W. Gillham Richard Mann Robert M. Roth Alan Weiner Arnold I. Caplan Yaacov Gluzman Thomas E. Manney Rodney Rothstein Gordon Carmichael Arthur Weissbach Alan R. Goldberg Julius Marmur Frank Ruddle Rosanna Mary E. Case Mitchell Goldfarb Steve Martin Suzanne B. Sandmeyer Weksberg C. Thomas Caskey Julian Gordon Michael Mathews Robert Sauer Peter Wensink Benoit Chabot Max E. Gottesman Lee McAlister-Henn Anatonio Scarpa Heiner Westphal Roger Chalkley Michael M. Gottesman Wes McBride Pamela Schaffer Jean-Marie Wiame Mark Challberg Frank Graham Michael McBurney Brian Schaffhausen Hunt Willard Michael Chamberlin Steve Grant B. J. McCarthy Randy Scheckman Dyann Wirth R. K. Chan Jay Greenberg Kenneth S. McCarthy, Jr. Robert Schimke Owen N. Witte Verne Chapman Jack Griffith Roderick McInnis Jeffrey A. Schloss John L. Woolford J. R. Christensen Leonard Guarente James A. McKanna Thomas Schmid Ronald L. Cihlar Ronald Worton Rao Gupta Anthony R. Means Bartholomew Sefton Keith Yamamoto James Cleaver Gordon Hager William C. Merrick Pravinkumar B. Sehgal Don Cleveland Mary Lou Harsa-King Janet Mertz Janice A. Sharp R. Rogers Yocum Philip Coffino Leland Hartwell Mark Meuth Stephen J. Sharp Elton T. Young Amos Cohen R. H. Haynes Elliot Meyerowitz Thomas Shenk Michael Young Stanley Cohen Lynna Hereford Carlo Moscovici Michael I. Sherman Virginia Zakian Michael Cole Larry Hightower Douglas B. Murphy Mark Shotwell R. S. Zitomer Christopher Coleclough David Hirsch David Nathan Carolyn Silflow Jonathan A. Cooper Michael J. Holland Daniel W. Nebert Robert T. Simpson AUTHOR INDEX VOLUME 4

Abovich. Nadja. 1871 Benjamin, Thomas L., 2774 Camper, Sally A.. 538 Covey. Lori. 1384 Abrahams, P. J., 2341 Bennett, Karen L.. 1561 Campisi. Judith. 1807 Coward. James K., 538 Acheson, Nicholas H.. 722 Bensaude. O.. 730 Cancedda. Ranieri. 1163 Cowell. Henry R.. 2010 Adam, Stephen A., 415, 1104 Ben-Tzvi. Bat-Sheva. 188 Candido. E. Peter M.. 1785 Cox. George N.. 2389 Adams, Sherrill L., 1843 Ben-Ze'ev. Avri, 1880 Cano. Cheryl L.. 1521 Craig. Elizabeth A.. 1454 Admon, Smadar, 552 Berg, Patricia E.. 368, 1664 Capasso. Olga. 1163 Crain. William R.. Jr.. 840 Adrian, Gwendolyn S., 1712 Berg, Paul, 1900, 1915 Cappello. Joe. 591. 2207. 2332 Crawford. Brian D.. 2932 Adzuma, Kenji, 2735 Bergsma, Derk J., 2498 Caputo. Antonella. 1551 Crawford. Dana R.. 1483 Aghion, Joel, 317 Berk, Arnold J., 966. 1293 Cardillo, Thomas S.. 1393 Crawford, L. V.. 1657 Ahiquist. Paul, 2876 Berns. Kenneth I., 1416 Carlson. Marian. 49. 54. 2750 Creasey. Abla A.. 2745 Ahmed, Asad. 195 Bestor, Timothy H.. 1800 Carmichael. Gordon G.. 2774 Crittenden. Sarah L.. 1252 Akusjarvi, Goran, 736 Bestwick, Richard K., 908 Carroll. Dana. 254 Croce. Carlo. 1306 Albers, Robert J., 538 Bienz, Brigitta. 1638 Carter. Barrie J.. 2072 Cross. Frederick R.. 1834 Alt, Frederick W., 2905 Bingham. Judy M.. 1152 Carter. Timothy H.. 563 Crouse. Gray F.. 2921 Alterman, Rhea-Beth M., 123 Birkenmeyer. Larry G., 583 Cartinhour. Samuel W., 931 Cryer. Byron L.. 604 Alwine, James C., 1460 Birnbaum, Daniel, 1695 Caruso. Maurizia. 2925 Culbertson. Michael R.. 2052 Amara, Susan G., 2151 Birshtein. Barbara K.. 1270 Caruthers. Marvin H.. 966 Cutting. Ann E.. 1730 Anderson. W. French. 17. 368. Bishop, J. M.. 2587 Celenza. John L.. 49. 54 Czosnek. Henryk H.. 1638 1664 Bishop. J. Michael. 1260, 1627. Celniker. S. E.. 2455 Czyzyk. Linda. 1689 Andrews, Nancy. 2905 2843 Cervera, Margarita M.. 2231 Anehus. Siw, 915 Biswas. Susweta. 1035 Chakrabarti. Sekhar. 435 Dahlberg. James E.. 2580 Antell. Elizabeth A.. 1951 Blanck. George. 559. 666 Chang. Caren. 1864 Dandolo. Luisa. 317 Anthony, James G.. 1115 Blangy. Daniel, 317 Chang. Kun Sang. 2498 Danielsen. Mark. 449 Arai. Ken-ichi, 407 Blatt, Cila. 978 Chatterjee. Pradeep K.. 2231 Danley. Dennis E.. 642 Arai. Naoko, 407 Blau. Helen. 1449 Chen. Cathy. 1326 Danna. Kathleen J.. 625. 1661 Araki, Hiroyuki. 203 Blochlinger. Karen. 2929 Chen. Suzie. 559. 666 Darnell. James E.. Jr.. 1929 Ariga, Hiroyoshi, 1476 Block. Timothy, 2091 Chen-Kiang. Selina. 2031 Darnell. Robert B.. 829 Arnheim, Norman, 221, 1306 Blose, Stephen H.. 2865 Chien. Yueh-Hsiu. 507 Das. G.. 133 Artishevsky, Alexander, 2364 Boardman. Mark, 2828 Chikaraishi. Dona M.. 1935. Dasgupta. Uma B.. 2227 Arvidson, Dennis N., 1293 Bock, Hans G. O.. 1978 2187 David. John R.. 1372 Arya, Suresh K., 2540 Boedtker. Helga. 1483 Chin, Nena W., 2802 Davide. Joseph P.. 38 Asche, Wolfgang, 923 Boettiger. David. 1420 Chin, Steven S.-M.. 454 Davidson. Norman. 358. 956, Ashman, Charles R., 2266 Bond, Julian F., 1313 Chisholm. George. 947 1343 Asselin. Claude, 755 Bonner. William M.. 1186 Chlebowicz-Sledziewska. Ewa. Davidson. Richard L.. 2266 Astrin, Susan M., 1096 Borde, Janine, 1141 2529 Davie. James R.. 985 Attardi, Giuseppe, 1605 Bostian, Keith A., 2818 Cho. Myung-Sam. 2214 Davis. Ronald L.. 358 Avignolo, Carlo, 276 Bouck, Noel, 1231 Choi. Yang Do. 415. 1104 Davis. Ronald W., 1440 Bouvier, Montserrat, 2594 Choi. Youngsook. 1278 Davison. Barry L.. 1221 Bowman, Lewis H.. 822 Chooi, W. Yean. 2535. 2643 Dawes, Ian W., 695 Babinet, C., 730 Bradshaw, Harvey D.. Jr., 2316 Chow. Terry. 2811 Dawid, Igor B.. 507 Babiss, Lee E., 563 Brady, John, 133 Christy. Barbara A.. 611 Dawson. Dean. 2661 Bailey, J. E., 2455 Brady, John N., 2911 Chu. Frederick K., 2858 Decker, Stuart. 1718 Bains, William, 1449 Brandriss, Marjorie C., 2837 Ciriacy. Michael. 61 Decker. Stuart J.. 571 Baker, Steven M., 2062 Brandt, Curtis R., 1270 Cirullo, Ronald E.. 1939 Deering. Reginald A., 2784 Bakken. Aimee H., 576 Branton, Philip E., 755, 1003 Clarke, Margaret. 1035 DeFeo-Jones. Deborah. 2298 Baldetorp, Bo, 915 Brazzell, Cheryl, 2573 Clarke, Michael F.. 890 Defeo-Jones. Deborah, 23 Baltimore, David, 2905 Breckenridge, Bruce M., 2091 Clayton. David F.. 1929 Deininger. Prescott L.. 2316 Bandyopadhyay, Pradip K., 743, Breugnot, Claude, 1141 Cleghon. Vaughn. 1354 Delegeane. Angelo M.. 2364 749 Brewer, Bonita J.. 2529 Clinton, Gail M.. 973 Delers. Anne. 809 Banerji, Sunandita S., 2437 Brilliant. Murray H., 2187 Coffino. Philip. 2082 DeLucia, Angelo L., 2631 Bank, Arthur, 2553 Broach, James, 1278 Cohen. Edward H.. 1515 Dennis, Douglas, 544 Banville, Denis. 2413 Brough, Douglas E.. 1354 Cohen, Stephen M.. 2207. 2332 DePinho. Ronald, 2905 Barbanti-Brodano, Giuseppe, Brown, Peter C., 1050 Cole. Georgette, 2306 Deppert. Wolfgang. 1542 Bargmann. Cornelia I., 1577 Brugge, Joan, 1738 Coleclough, Christopher, 2017 Derman, E.. 2259 Barkan, Alice, 813 Brugge, Joan S.. 1420 Coleman, Annette W.. 618 DesGroseillers, Luc, 151 Barnekow, Angelika, 1179 Brunel, Claude, 1890 Collett, Marc S.. 1213 de Souza. Comlan Aristide, 2413 Barnes, Georjana, 2381 Brunke, Karen J., 1115 Colletta. Giulia. 923 Dickinson. Douglas P., 2321 Baserga, Renato, 276 Bryant, Debra L.. 862 Colombo, Mauro M., 1725 Dickson. Clive, 375 Basi, Guriqbal S., 2828 Buchman, Andrew R.. 1900, Cook-Deegan. Robert. 1935 Dickson. Elizabeth, 310 Basilico, Claudio, 2925 1915 Cooley. Lynn. 2714 Dieckmann, Barbara, 166 Bastin, Marcel, 755 Burgess. Wilson H., 2224 Cooper. Geoffrey M.. 2247 Diehl, Ronald E., 1096 Battula, Narayana. 1073 Burke, Deborah Johnson, 2714 Cooper, Jonathan A.. 30 Diggelmann. Heidi, 1057, 2929 Beall, Clifford J., 1669 Burns, Daniel K., 2643 Cooper, Terrance, 947 DiMaio, Daniel, 340 Beaudet, Arthur L., 1978 Buss, Janice E., 2697. 2705 Copeland, Neal G.. 2899 Dinsart. Christiane, 324 Becker, Dorothea, 2247 Byrd, Philip J.. 110 Corallini. Alfredo. 1551 Diu. A.. 730 Belfort, Marlene, 2858 Corbin, Victoria, 340 Dixon. Kathleen, 1286 Belsham, Graham J., 1334 Corces, Victor G., 2883 Dobkin, Carl. 2553 Belzer, Susan K., 1213 Calos, Michele P., 1951 Cornelis, Jan J.. 324 Dodgson, Jerry B., 2498 Bendig, Mary M., 567, 2109 Campbell. J. L., 2455 Costlow. Nancy. 1853 Donegan, James, 1815 ii AUTHOR INDEX MOL. CELL. BIOL.

Donini, Pierluigi, 1725 Friedberg, Errol C., 290, 2161 Harashima, Satoshi, 203, 771 Jha, Krishna K., 2549 Donovan-Peluso, Maryann, 2553 Fromm, Michael. 1900 Harland, Richard M., 1769 Joffe, Sandor, 435 Doty, Paul, 1483 Funanage, Vicky L., 2010 Harper. Mary E., 978 Johnston, John, 1864 Dove, William F., 1706 Harter, M. L., 1427 Johnston, Mark, 1440 Dowds, Barbara C. A., 2273 Gaber, Richard F., 2052 Harvey, Robert, 1334 Jolicoeur, Paul, 151 Dreyfuss, Gideon, 415, 1104 Gaines, George, 1605 Hassell, John A., 2406, 2594 Jones, Donald, 1785 Driscoll, Robert, 26 Gallimore, Phillip H., 110 Hastie. Nicholas D., 1561 Jones, Peter A., 2098 Drobetsky, Elliot, 1792 Gallo, Robert C., 2540 Hattman, Stanley, 599, 985 Jongens, Tom, 514 Drummond, Robert J., 2745 Ganesan, Ann K., 1169 Hauschka, Stephen D.. 1777 DuBridge, Robert B., 1951 Ganguly, Subinay, 123 Hawley, Robert G., 2565 Kaback, H. Ronald, 199 Duff, Catherine, 69 Garber, Ellen A., 454, 1834 Hayward, Gary S., 2214 Kabat, David, 908 Dumas, Lawrence B., 583 Garcia, Rurico, 840 Heard, Jean Michel, 216 Kakunaga, Takeo, 1073, 2610 Dunsworth-Browne, Marguerite, Gardinier, Minnetta, 1206 Heath, I. Brent, 1198 Kamiryo, Tatsuyuki, 2136 1293 Garrett, James E., 254 Heath, John K., 1561 Kamps, Mark P., 2697 Durnam, Diane M., 484 Gattoni-Celli, Sebastiano, 634 Heby, Olle. 915 Kan, Yuet Wai, 1469 Gelinas, Celine, 755 Heintz, Nathaniel, 2723 Kane-Haas, Colleen, 1561 Eckhart, Walter, 282, 817 Gerstenfeld, Louis C., 1483 Helinski, Donald R., 173 Kao, Hung-Teh, 867 Edlund, Louise, 1695 Gesteland, Raymond F., 260, 268 Hellewell, Susan B., 1800 Katze, Michael G., 2198 Eiden, Maribeth, 890 Ghosh, Prahlad C., 1320 Hendricks, Marvin, 1823 Kaufman, Elliot R., 2449 Eisenman, Robert N., 2486 Gilboa, Eli, 2289 Henikoff, Steven, 1515 Kaufman, Randal J., 1970 Eisenstadt, Jerome M., 618 Gillett, Peter, 1334 Henry, Susan A., 2479 Kaur, Kiran, 1013 Ellinger, Mark S., 2298 Gilmer, Tona M., 846 Herrick, Glenn, 2661 Kawai, Sadaaki, 1172 Ellis, Ronald W., 989 Ginsberg, Harold, 1528 Herrick. Glenn A., 931 Kayman, Samuel C., 1035 Ellwood, Marian S., 1454 Givol, David, 1638 Herskowitz, Ira, 2420 Kedes, Larry, 1449, 1961 El-Sherbeini, Mohamed, 2818 Gluzman, Yakov, 302, 1125, Hession, Catherine A., 38 Keh, William, 2802 Emr, Scott D.. 2347 1653 Hicks, James, 1278 Kellems, Rodney E., 2921 Englesberg, Ellis, 799 Goldberg, Alfred L., 442 Hightower, Lawrence E., 1534 Kemper, Wayne M., 17 Enrietto, Paula J., 1508 Goldberg, Allan R., 454 Hildebrand, Carl E., 2932 Kim, Young-June, 468 Epstein, Lloyd M., 1583 Goncalves, Otelinda, 1792 Hill, John C., 583 King, Robert M., 923 Erdman, Valerie D., 1730 Gonzales, Felicidad A., 2098 Hill. Robert E., 1561 Kingston, Robert E., 1970 Erikson, Eleanor, 77 Goodfellow, P., 1657 Hiller, Ruth, 199 Kinsey, John A., 117, 2041 Erikson, R. L., 77, 1631 Gorman, Cornelia M., 2622 Hinnebusch, Alan G., 1326 Kinsley, Stephen, 529 Erisman, Michael D., 1096 Gottesman, Michael M., 2639 Hinnen, Albert, 2668 Kirschmeier, Paul, 634 Ernst, Susan G., 840 Goyette, Michele, 1493 Hirsh, David, 2389 Kitani, Takako, 1591 Errede, Beverly, 1393 Grabowy, Constance, 2103 Hirsh, Jay, 1669 Klar, Amar, 1278 Esmon, Pam, 2347 Grand, Roger, J. A., 110 Hoffman, Eric P., 2883 Klass, Michael R., 529 Evan, G. I., 2587 Granger, Bruce L.. 1943 Hogan, Aileen, 2239 Klein, Binie, 324 Evan, Gerard I., 2843 Grant, David M., 2041 Holcomb, Cherie L.. 2381 Klein, Hannah L., 329 Evans, Ronald 2151 Graves, Reed A.. 351 M., Green, H., 228 Holland, Lene J., 2543 Klempnauer, K.-H., 2587 Green, 1706 Hollenberg, Cornelis P., 1191 Klessig, Daniel F., 1354 Fahey, Dale, 1754 Larry L., Hook, Amy G., 2921 Kletzien, Rolf F., 1079 Falkenthal, Scott, 956 Greenwood, Michael T.. 2858 Hoosein, Mansoor A., 247 Klockmann, Ulrich, 1542 Fangman, Walton L., 1618, 2529 Greer, Helen, 520 Hopper, James E., 1238, 1521 Ko, Jone-Long, 1427 Faras, Anthony J., 203 Greisen, Kay S., 1951 Horowitz, Heidi, 2509 Koch, Gebhard, 199 Farmer, Stephen R., 1313 Gronostajski, Richard M., 442 Houston, Joanna M., 1561 Koch, Tamar, 2128 Farrell-Towt, James, 2676 Groppi, Vincent E., Jr., 2082 Howard, Bruce H., 2622 Kokkinakis, Demetri, 1231 Fasano, Ottavio, 1695 Gross, Kenneth W., 2321 Howe, Chin C., 1. 2428 Koltin, Y., 188 Faust, Emanuel A., 2239 Grossi, Maria P., 1551 Howles, Philip N., 2321 Kon, Christine. 2091 Fausto, Nelson, 1493 Groudine, Mark, 1769 Hozumi, Nobumichi, 2565 Kopchick, John J., 240 Feldman, Lawrence T., 867 Grzeschik, Karl-Heinz, 989 Hsiao, Wen-Luan W., 634 Kosik, Elaine, 1738 Fewell, Joseph W., 2128 Gudas, Lorraine J., 2142 Hsie, Abraham W., 1411 Kothary, Rashmikant K., 1785 Fichelson, Serge, 216 Gudewicz, Tom, 387 Huang, Paul L., 1372 Kozak, Christine, 375 Field, Loren J., 2321 Gull, K., 779, 1182 Hughes, Stephen, 1738 Kozak, Christine A., 997 Fiers, Walter, 232 Gunning, Peter, 1961 Huitema, B. A., 2341 Kramer, James M., 2389 Findly, R. Craig, 2170 Gupta, Radhey S., 1761 Hunter, Tony, 30, 2705 Kraus, Kevin W., 2170 Fink, Gerald R., 1246, 1326 Guyaux, Michel, 1627 Hutchison, Keith W., 2899 Kreuger, James G., 454 Firtel, Richard A., 671, 2890 Haber, James E., 2509 Hutton, John J., 1712 Krug, Robert M., 2198 Firzlaff, Juliane M., 1057 Haguenauer-Tsapis, Rosine, 2668 Hwang, Lih-Hwa Sherry, 2289 Kruger, Kelly, 2905 Fisher, Eric F., 966 Hallberg, Richard L., 2170 Krzywicki, Karen A., 2837 Fisher, Paul B., 563, 1572 Halvorson, H. O., 1682 Imperiale, Michael J., 867, 875 Kuff, Edward L., 2128 FitzGerald, David, 1528 Hamada, Hiroshi, 1073, 2610, Ingolia, Thomas D., 2573 Flatau, Edith, 2098 2622 Ingram. Vernon M., 1800 Lai, Bai-Tang, 2802 Flatgaard, Jeffrey E., 2306 Hamilton, Robert W., 1238, 1521 Innis. Jeffrey W., 1499 Lai, C.-J., 8 Flint, S. J., 1363 Hanafusa, Hidesaburo, 454, 1834 Innis. Michael, 166 Lam, Brenda S., 254 Flintoff, Wayne F.. 69 Hanahan, Douglas, 302 Innis. Michael A., 2306 Lambie, Eric J., 703 Focht, Richard J., 1843 Hanawalt, Philip C., 1169 lovannisci, David M., 1013 Lambowitz, Alan M., 2041 Fogh, Jorgen, 1695 Hand, Roger, 1815 Ismail, Sajida, 1278 Lane, Mary-Ann, 2247 Forbes, Douglass J., 2580 Handa, Hiroshi, 791 Laingstrom, Eva, 915 Forney, James D., 1583 Hankinson, Oliver, 1597 Jaehning, Judith A.. 2062 Lanks, Karl W., 2802 Franchini, Genoveffa, 978 Hanley, Susan, 1985 Janda. Michael, 2876 LaRosa, Gregory J., 2142 Francoeur, A. Michele. 1134 Hann, Stephen R., 2486 Jeang. Kuan-Teh. 2214 Last. Robert L., 2396 Fransen, Lucie, 232 Hannig, Ernest M., 92, 101 Jeanteur, Philippe, 1890 Lau, Alan F.. 203 Frayne, Elizabeth G., 2921 Hansen, William. 2347 Jefferson. Douglas M.. 1929 Lau, Yun-Fai, 1469 Freytag, Svend O.. 1978 Hansen, William J., 2381 Jenkins. Nancy A.. 2899 Laughon, Allen, 260 VOL. 4. 1984 AUTHOR INDEX ii

Law. Martha L., 989 McCabe. Peter. 2306 Nunberg. Jack H.. 2306 Pruitt. Steven C.. 2851 Lawyer. Frances C., 2306 McCairns. Eric. 1754 Nur. Uzi. 599 Przybyla. Alan. 468 Lazarides. Elias, 1943 McClanahan. T.. 2356 Nusse. Roel. 2532 Ptashne. Mark. 1985. 2467 Leavitt. John. 1961 McClung. J. Keith. 1079 Purchio. A. F.. 1213 Lebkowski, Jane S., 1951 McCormick. Frank. 166 O'Brien. William E.. 1978 Lee, Amy S.. 2364 McCoy. Melissa S.. 1577 Ogawa. Hideyuki. 2735 Queen. Cary. 1042 Lee, Douglas, 1551 McEntee. K.. 2356 Ogawa. Tomoko. 2735 LeFebvre, Rance B.. 1416 McGowan. Ross A.. 2321 Oishi. Karen K.. 2556 Radonovich. M.. 133 Leibovitz. Noemi. 982 McKnight. Steven L.. 1769. 1777 Oishi. Michio. 1159 Radonovich. Michael, 2911 Leibowitz, Michael J.. 92. 101 Meade. James H.. 2306 Okazaki. Koei. 2136 Rambosek. John A.. 117. 2041 Lelay-Taha, Marie-Noelle. 1890 Melera. Peter W., 38. 2370 Okazaki. Tuneko. 1591 Raney. P.. 1682 Lesley. Jayne F.. 1675 Mellstrom. Karin. 1738 Okkema. Peter G.. 2062 Razzaque. Abdur. 435 Leuders. Kira K.. 2128 Mercer. W. Edward. 276 Olson. Maynard V.. 657 Reeder. Ronald H.. 576, 2851 Lev, Ze'ev, 982 Merrill. Gary F., 1769. 1777 Oostra. Ben A.. 1334 Reid. Lola M., 1929 Levine. Roy A.. 2142 Mertz. Janet E.. 813 Oppermann. Herman. 1260 Reitz. Marvin S.. Jr., 890 Levy. Jean Paul, 216 Mes-Masson. Anne-Marie. 2594 Ord. Robin W., 2858 Resche-Rigon. Michelle. 1141 Lewin, Alfred S.. 247 Meuth. Mark. 1792 Oren. Moshe. 552. 1638. 2180 Resnick. Michael A.. 2811 Lewis. George K.. 2843 Mevarech. M.. 188 O'Rourke. Edward C.. 2745 Rettenmier. Carl W., 1999 Lewis. U. J.. 228 Michalowsky. Lesley A.. 2098 Osborne. lTimothy F.. 1293 Reveillaud. Isabelle. 1890 Leys, Eugene J., 2921 Michitsch, Richard W.. 2370 Oshima. Takehiro. 203 Ricciardi. Robert P.. 1551 Liang. T. Jake. 2774 Miesfeld. Roger. 221 Oshima. Yasuji. 203. 771 Richter. Andrea. 151 Liboi. Elio. 2925 Miesfield. Roger. 1306 Ostertag. Wolfram. 923 Ridley. Susan Porter. 761 Lin, B.-C.. 8 Milanesi. Gabriele. 1551 Ostrowsky. Julie. 1231 Rine. Jasper. 2381 Lin. C. C.. 1469 Milcarek. Christine. 1270 Otaka. E.. 2535 Ringold. Gordon. 166 Lin. Ching-Shwun. 1961 Miller. D.. 779 Overton. G. Christian. 2428 Riva. Silvano. 1416 Lin, Fwu-L,ai. 852. 1020 Miller. Jacqueline S.. 1372 Oxender. Dale L.. 475 Roberts. Bryan E.. 1372 Linder. Stig. 618 Miller. Lois K.. 399 Ozer. Harvey L.. 151. 1815. 2549 Robertson. Hugh D.. 310 Ling. Victor, 500 Milman. G.. 1641 Robertson, Scott M.. 500 Lingrel. Jerry B.. 2120 Milman. Gregory. 1644 Palmiter. Richard D.. 484. 1221 Robinson. Gregory S.. 1313 Lipsich. Leah. 1420 Milovanovic. Zahra Zakeri. 563 Pantazis. Panagiotis. 1186 Robinson. Patricia, 23 Lis. John T.. 1853 Mirdamadi. Behzad. 2858 Papageorge, Alex G.. 23 Roeder. G. Shirleen. 703 Litzkas. Philippe. 2549 Mishoe. FHelena. 2911 Pardee. Arthur B.. 442. 1807 Roeder, Robert G.. 2723 Liu. H.-Y.. 160 Mitchell. Aaron P.. 2758. 2767 Park. Jongsang. 2289 Roff. Calvin F.. 1252 Livingston. Elizabeth. 69 Mitchell. Diane J.. 2818 Parker. Vann P.. 956 Rommelaere. Jean, 324 Lobaton. Carmen D.. 475 Miyajima. Atsushi. 407 Parsons. J. Thomas. 862 Rosbash. Michael. 1871 Lodish. Harvey F., 591. 2207. Miyajima. Ikuko. 407 Pastan. Ira. 1528. 2639 Rosenbaum. Joel L.. 424 2332 Moehring. Joan M.. 642 Patschinsky. Tilo. 2705 Rosenfeld. Michael C.. 2151 Loewy. Brenda S.. 2479 Moehring. Thomas J.. 642 Paz-Aliaga. Benjamin. 840 Roskoski. Robert. Jr.. 973 Longmire. Jonathan L.. 2932 Moffett. John. 799 Pekkala. David. 1198 Roth. Charles. 2639 Look. A. Thomas. 1999 Mok. Minsen. 2031 Pellman. David. 1834 Rothberg. Paul G.. 1096 Loomis. William F.. 514. 2273 Montell. Craig. 966 Penman. Sheldon. 2231 Rotheim. Minna B.. 681 Lopez. Linda C.. 529 Montgomery. Donna L.. 939 Penn. Monica Driscoll. 520 Rotter. Varda, 383, 552. 1402 Lord, Susan T.. 1635 Montgomery. Kate T.. 2370 Pennie. Sheila. 923 Rottman. Fritz M.. 538 Love. Bruce. 681 Morange. M.. 730 Pennock. Gregory D.. 399 Roussel. Martine F., 1999 Lucchini, Giovanna. 1326 Moreno. Alfredo. 475 Percival-Smith Anthony. 142 Rovigatti. Ugo G.. 1096 Luciw. Paul A.. 1260 Morikawa. M.. 228 Perlman. D.. 1682 Rowe. Peter B.. 1754 Lugg, David K.. 2428 Morimoto. Richard 1.. 2437 Perry. Robert P.. 2518 Rubnitz. Jeffrey, 2253 Lund. Elsebet, 2580 Morrison. Sherie L.. 1270 Peters. Gordon. 375 Ruddle. Frank H.. 383. 1638 Lutzker, Stuart. 2905 Mortimer, Robert K., 1864 Petes, Thomas D., 329 Russell. D. G.. 779. 1182 Lycan. Deborah E., 625 Moses. Priscilla A.. 2010 Petrino. Marianne G.. 2610 Rymond. Brian C.. 1191 Mueller. Christopher R.. 2594 Petropoulos. Christos J.. 1493 Machanoff, Richard, 1411 Muller. William J.. 2406 Philbrick. William M.. 2321 Sachdeva. Meena. 296 Machida, Curtis A., 908 Munk, A. Christine, 2932 Pietras. Dennis F.. 1561 Sadofsky, Moshe, 1460 Macinnes, Mark A., 1152 Murray. Ben A.. 514 Pinhasi. Orit. 2180 Safer. Brian. 17 Macklin, Michael D., 2643 Murray, Maryanne, 1754 Platt, Terry. 994 Sager, Ruth. 2103 Maderious, Alan, 2031 Muscat. George E. O.. 1754 Plumb. M. A.. 1363 Saggioro, Daniela. 809 Magasanik, Boris, 2758, 2767 Myoda, T. Timothy. 2010 Podgorski. Gregory. 2784 Sakaguchi, Alan Y., 989 Maine, Gregory T., 86 Pohjanpelto. Pirkko. 915 Sakaguchi. Junko, 651 Major, Eugene O.. 379 Naujokas. Monica A.. 2406 Pollack. Robert. 559. 666. 1572 Sakai. Kazuhisa. 651 Maller, James L., 1631 Naumovski. Louie. 290 Polonoff. Ethel. 908 Salzman, N. P.. 133 Maltzman. Warren, 1689 Nawrocki. John F.. 203 Ponte. Phyllis. 1449 Salzman. Norman P.. 2911 Mangel. W. F., 160 Naylor, Susan L.. 989 Poole. Stephen J.. 671 Sandbank, Tracey. 2072 Maniatis. Tom, 340 Negrini. Massimo. 1551 Popovic. Zvezdana. 1664 Sanders. Marilyn M., 2676 Mann, Dean L., 890 Nellen. Wolfgang, 2890 Porreca, Patricia. 1961 Sano, Hiroshi, 2103 Manos, M. Michele, 1,25 Nelson. Robert L.. 1003 Porter. Tom. 387 Sarkar, Saumyendra. 2227 Markoff. L., 8 Nesbitt. Muriel N., 978 Post-Beittenmiller. Martha A.. Sarokin. Laura, 2750 Maroney. Patricia A., 2235 Nevins. Joseph R.. 867, 875 1238 Scangos. George A.. 611 Martial, Marie Antoinette, 216 Ng. Sun-Yu, 1961 Powers. Scott. 1572 Scarbrough. Kathryn, 599 Marzluff, William F., 123, 351 Nilsen, Timothy W.. 2235 Pratt. Diane McMahon, 1372 Scarpulla. Richard C., 2279 Mathews, Michael B., 1063, 1134 Nishizawa, Makoto. 1172 Pravtcheva. Dimitrina. 383 Schaack. Jerome. 2714 Matsumura, Philip. 379 Nitiss, John, 2811 Pravtcheva. Dmitrina D.. 1638 Schaefer, Andras, 199 Mattox. William W., 956. 1343 Nobis. Peter. 923 Prescott. David M.. 1725 Schartl. Manfred, 1179 May, Evelyne, 1141 Nomura, Shintaro, 1159 Prives. Carol. 1278 Schauer. Irene, 2347 May, Pierre. 1141 Norstedt, Gunnar. 1221 Proffitt. John H.. 985 Schekman. Randy. 2347 iv AUTHOR INDEX MOL. CELL. BIOL.

Schild, David, 1864 Stafford, Jeannine, 1042 Theodorakis, Nicholas G., 2437 Weir-Thompson, Elizabeth M., Schildkraut, Carl L., 123 Stallcup, Michael R., 449 Thiele, Dennis J., 92, 101 695 Schimke, Robert T., 1050 Stallings, Raymond L., 2932 Thireos, George, 520 Wellner, Robert B., 1320 Schlesinger, Milton J., 688 Stanek, Albert E., 2802 Thirion, Jean-Paul, 2413 Wen, Duanzhi, 688 Schloss, Jeffery A., 424, 2686 Stanfield, Sharon W., 173 Thomas, Barbara, 2714 Wesolowski, Micheline, 181 Schulman, Howard, 1175 Stankowski, Leon F., Jr., 1411 Thomas, G. Paul, 1063 West, Michael H. P., 1186, 2072 Schulte, Roberta J., 1675 Stanners, Clifford P., 500 Thompson, E. Aubrey, Jr., 822 West, Robert, 1985 Schulze, Dan H., 123 Stark, Benjamin C., 2643 Thompson, Larry H., 1152 West, Robert W., Jr., 2467 Schwartz, Robert J., 2498 Staufenbiel, Matthias, 1542 Thorburn, Patricia, 2509 Wheeler, Steve, 514 Schweickart, Vicki, 2306 Stavenhagen, Jeffrey B., 2396 Thoren, M., 133 White, Allen, 387 Sclafani, Robert A., 1618 Steele, Robert E., 576 Tilghman, Shirley M., 898 White, Carol N., 1534 Scolnick, Edward M., 23, 989, Stein, G. S., 1363 Tindall, Kenneth R., 1411 White, Eileen, 2865 2298 Stein, J. L., 1363 Tipper, Donald J., 2818 White, James H., 1286 Scott, Walter A., 604, 1499 Stein, Roland, 2792 Tlsty, Thea D., 1050 Whiteway, Malcolm S., 195 Scotto, Kathleen W., 38 Steinberg, Robert A., 1086 Tobey, Robert A., 2243 Whittaker, Joanne L., 110 Seagrave, JeanClare, 2243 Sternberg, Edmund J., 1115 Toledo, D. L., 160 Wickner, Reed B., 181, 761, Searle, Peter F., 1221 Sternberg, Nat, 852, 1020 Tolunay, H. Eser, 17 1747 Sefton, Bartholomew M., 30, Stillman, Bruce W., 2865 Tomasiewicz, Henry G., 77, Wiedemann, Leanne M., 2518 2697, 2705 Stimac, Eva, 2082 1935 Wiginton, Dan A., 1712 Segall, Jacqueline, 142 Stoker, Andrew W., 1508 Torchia, Timothy E., 1521 Wigler, Michael, 1695 Segev, Orit, 982 Stollar, B. David, 2610 Trahey, Meg, 166 Wilkie, Thomas M., 1221 Seidman, Michael, 435, 2610, Storms, Reginald K., 2858 Trainor, Cecelia D., 890 Williams, Jeffrey G., 567, 2109 2622 Storrie, Brian, 296 Tratschin, Jon-Duri, 2072 Willingham, Mark, 1528 Seth, Prem, 1528 Storti, Robert V., 2828 Tsichlis, Philip N., 997 Wills, Norma, 268 Sette, Margaret, 468 Strathern, Jeffrey, 1278 Tunnacliffe, A., 1657 Wilson, John H., 387 Shahan, K., 2259 Strauss, P. Gunter, 997 Tyau, Edward S., 1293 Wilson, Katherine L., 2420 Shank, Peter R., 1493 Strickland, Sidney, 867 Tye, Bik-Kwoon, 86 Wittman, Vaughan P., 2306 Shapiro, Daniel R., 2556 Strniste, Gary F., 1152 Wolf, David, 383, 552, 1402 Shapiro, Steven G., 2120 Stuart, Gary W., 1221 Ueyama, Hisao, 1073 Wong-Staal, Flossie, 2540 Sharp, Phillip A., 791, 1970 Stubblefield, Elton, 1627 Ullman, Buddy, 1013 Wood, Debra, 2017 Shaw, Karen J., 657 Subramani, Suresh, 2253 Ulsh, Linda S., 1647 Wood, Karen M., 822 Sheiness, Diana, 1206 Sueoka, Noboru, 2187 Woodworth-Gutai, Mary, 1561 Sherman, Fred, 1393 Sugino, Akio, 2811 Woolford, John L., Jr., 2396 Sherr, Charles J., 1999 Summers, William C., 2227 Van Arsdell, Scott W., 492 Worton, Ronald G., 69 Shih, Thomas Y., 1647 Surosky, Richard T., 86 van der Eb, A. J., 2341 Wright, Cynthia F., 2023 Shilo, Ben-Zion, 982 Sussman, D. J., 1641 van der Eb, Alex J., 324 Wright, Dowain, 1730 Shoemaker, Charles, 399 Sveda, M. M., 8 Van Doren, Kevin, 1653 Wright, Peter J., 2631 Shulman, Marc J., 2565 Svensson, Catharina, 736 Van Eldik, Linda J., 883, 2224 Wu, Henry C., 1320 Shuman, Jon, 468 Swanton, Marshal T., 1725 Van Gurp, John R., 1597 Wyke, John A., 1508 Sibley, Eric, 340 Sweder, K., 2455 van Heerikhuizen, Harm, 2532 Silan, Colleen, 2890 Swinton, David, 985 van Kessel, Ad Geurts, 2532 Yamamoto, Masayuki, 651 Silflow, Carolyn D., 424, 2686 Symonds, G., 2587 van Ooyen, Albert, 2532 Yang, Elizabeth, 2161 Silver, Julie C., 1198 Symonds, Geoff, 1627 Van Roy, Frans, 232 Yang, Linda, 17 Silverman, Sanford J., 1246 Szekeley, Elizabeth, 939 van 't Veer, Laura J., 2532 Yang, P. P., 160 Simon, Melvin I., 978 Szpirer, Claude, 809 Varet, Bruno, 216 Yang, Ueng-Cheng, 1363 Singer, Maxine F., 1635 Szpirer, Josiane, 809 Varmus, Harold E., 1260 Yasumoto, Shigeru, 712 Sive, Hazel L., 2723 Viers, Virginia S., 296 Yocum, R. Rogers, 1985, 2467 Skoultchi, Arthur I., 123 Taguchi, Aileen K. W., 61 Vlahakis, George, 2639 Yoda, Kin-ya, 1591 Smiley, James R., 544 Tajana, Gianfranco, 1163 Voronova, Anna, 282 Young, Elton T., 61 Smith, Alan E., 1334 Takagi, Atsuko, 771 Voronova, Anna F., 2705 Young, Katherine, 2553 Smith, Michael, 703 Tal, Rony, 2306 Young, Leo, 1013 Sola, Brigitte, 216 Talbot, Brian, 2413 Wake, Claire T., 387 Young, Peter R., 898 Soll, Dieter, 2714 Tamanoi, Fuyuhiko, 1738 Waldman, Alan S., 1644 Youngblom, James, 2686 Sollner-Webb, Barbara, 1306 Tamarkin, A., 188 Walter, Charles F., 604 Solomon, Frank, 371 Tanaka, Kazuma, 203 Walthall, Deborah A., 1191 Zabel, Bernhard U., 989 Sommer, Steve S., 1747 Tarpley, W. Gary, 2653 Wang, John L., 1252 Zakut-Houri, Rina, 1638 Sommer, Steven S., 761 Tatchell, Kelly, 2298 Wangh, Lawrence J., 2543 Zendegui, Joseph G., 883 Sompayrac, Lauren, 1661 Teague, Michael A., 1393 Wamnecke, Gunther, 923 Zeng, Gui-Chao, 1815 Sorge, Joe, 1730 Tegtmeyer, Peter, 2631 Wasmuth, John J., 1939 Zibirre, Richard, 199 Sperle, Karen, 1020 Temeles, Gretchen, 23 Watterson, D. Martin, 883, 2224 Zielinski, Raymond E., 883 Spivack, Jordan G., 1631 Temeles, Gretchen L., 2298 Weeks, Donald P., 1115 Zieve, Gary, 371 Spivak, Graciela, 1169 Temin, Howard M., 743, 749, Weinberg, Robert A., 1577 Ziff, Edward B., 2792 Srienc, F., 2455 2653 Weiner, Alan M., 492 Zimmer, Warren E., Jr., 2498 Sri-Widada, Joannes, 1890 Templeton, Dennis, 282, 817 Weinstein, I. Bernard, 634 Zitomer, Richard S., 1191, 2023 Stacey, Dennis W., 240 Tewari, Krishna K., 2556 Weintraub, Harold, 1823 Zuker, Charles, 591 SUBJECT INDEX VOLUME 4

Abelson murine leukemia virus-trans- plasmid pKHAO. 1427 a2 product formed cells plasmid pKHBO, 1427 S. cerevisiae, 2420 aberrant p53 mRNA, 552 Adenovirus 5 STE6 expression. 2420 Abelson virus-transformed B-lymphoid E2 transcription unit A protein cell line ElA-inducible promoter with an ele- binding to DNA, 2631 heavy-chain class switching, 2905 ment that functions independent- SV40, 2631 switch region deletion, 2905 ly of position or orientation, 875 aprt locus abl rescue of functional replication origins, alterations induced by deoxyribonucleo- Drosophila homolog, 982 302 side triphosphate pool imbalances Achlya ambisexualis transcription in infected HeLa cells in CHO cells, 1792 heat shock treated with 12-O-tetradecanoyl- Argininosuccinate synthetase gene. hu- chromatin, 1198 phorbol-13-acetate, 563 man nuclear protein phosphorylation, 1198 Adenovirus 5 Ela alternative mRNA splicing, 1978 Acid phosphatase secretion HeLa cell 1-tubulin gene transcription. ARSI sequence S. cerevisiae, 2668 2792 S. cerev'isiae. 2455 Actin gene fusion Adenovirus E I B Aryl hydrocarbon hydroxylase-deficient D. discoideum. 2890 mRNA synthesis Hepa-l mutants transformation, 2890 control by shift in RNA splice sites. revertants, 1597 Actin genes 966 Asparagine-linked glycosylation chicken, 2498 Adenovirus Ell promoter S. cerevisiae. 2381 constitutive expression, 840 transcription regulation by Ela gene Asparaginyl-tRNA synthetase embryo-specific expression, 840 products, 1970 CHO cells. 1939 human smooth muscle, 1073 Adenovirus-simian virus 40 recombinant Aspergillius awvamori mouse skeletal muscle cell differentia- human fibroblast transformation. 1653 glucoamylase gene, 2306 tion, 1449 Adenovirus 12-transformed HEK cell A system muscle-specific expression, 840 lines, 110 CHO mutants sea urchin, 840 Adipose conversion amino acid transport. 799 P-Actin genes, human, 1961 human growth hormone. 228 gene regulation, 799 Actin mRNA levels mouse cells. 3T3, 228 AUG codon of herpes simplex thymidine lectin activation of lymphocytes. 1754 African green monkey cells kinase gene Adeno-associated virus SV40 induction by cell fusion, 1159 retrovirus vector. 743 DNA replication UV irradiation, 1159 Aitographa (alifornica nuclear polyhe- conformation, 1416 A431 human epidermoid carcinoma cells drosis virus sequence, 1416 epidermal growth factor. 571 E. coli ,B-galactosidase expressed in in- Adeno-associated virus as a eucaryotic Alpha gene expression sect cells. 399 vector HeLa cells Autonomously replicating activity transient expression and encapsidation sodium butyrate, 829 micronuclear DNA of 0. nova contains of the procaryotic gene for chlor- Alpha tubulin sequences with autonomously rep- amphenicol acetyltransferase, 2072 C. fasciculata licating activity in S. cerev'isiae, Adenosine deaminase mRNA flagellar regeneration. 1182 1725 human cell lines, 1712 Alu family sequences Avian erythroblastosis virus Adenovirus hnRNAs of HeLa. KB, and L cells. 310 transduction of cellular oncogenes. 1627 DNA-binding protein, 1354 replication during cell extract-promot- Avian macrophages early genes ing SV40 DNA synthesis. 1476 src from RSV, 1420 EIA-like activity, 867 am Avian myb products human histone genes, 1363 N. crassa transformation, 117 monoclonal antibodies, 2843 La antigen recognizes and binds to the Amino acid Avian myeloblastosis virus-transformed 3'-oligouridylate tail of a small alterations in pp60,r( myeloblasts RNA, 1134 tyrosine protein kinase activity, 862 induced differentiation, 2587 lysis receptosomes analogs Avian retrovirus penton base, 1528 HeLa cell exposure. 1063 DNA ligation major late transcriptional unit transcription, 1063 microinjection, 240 premature termination by human translation, 1063 transfection, 240 RNA polymerase II, 2031 biosynthesis 5-Azacytidine Pseudomonas exotoxin toxicity, 1528 mRNA derepression, 520 BHK cells, 1231 toxic gene introduced into a human cell, S. cerevisiae, 520 carcinogenesis induction, 1231 1354 temporal analysis, 520 DNA sequences in C3H IOTI/2 cells, transcription transport 634 early region IV, 791 A system, 799 hepatoma cells transcription control region, 1293 CHO mutants, 799 ornithine carbamoyl transferase. 809 tumor antigen Aminopterin resistance 5-Aza-2'-deoxycytidine-resistant variants nuclear envelope localization and in- CHO mutant cells, 1152 of C3H IOT1/2 C18 cells tegrity of cellular DNA, 2865 Amphotropic retrovirus vector system DNA methylation, 2098 VA RNA, human cell gene transfer, 1730 mRNA translation, 736 Amplification of hypoxanthine-guanine Baby hamster kidney cells Adenovirus 2 phosphoribosyltransferase genes, 618 5-azacytidine, 1231 EIA protein synthesis, in E. coli, 1427 Amplified domain cAMP-dependent protein kinase E1B protein synthesis in E. coli, 1427 human neuroblastoma cells, 2370 catalytic subunit, 1079

v vi SUBJECT INDEX MOL. CELL. BIOL.

carcinogenesis induction, 1231 cAMP-dependent protein kinase, 1079 Chinese hamster cells growth kinetics, 1079 CDC8 2-deoxygalactose-resistant, galactokin- protein kinase activities, 973 S. cerevisiae, 583 ase-deficient mutants, 2413 RSV infected, 973 cDNA galK structural mutations, 2413 Bacillus subtilis CHL cells, 38 gene expression ribosomal protein S6 homology, 2535 clone complementary to sequences for enhancing sequence, 368 Baculovirus vector a 34-kilodalton protein that is a metallothionein I and II genes, 2932 A. californica nuclear polyhedrosis vi- pp60v-src substrate, 1935 metallothionein inducibility, 2243 rus D. discoideum spore coat protein gene, mutation frequency in shuttle vector se- E. coli ,-3galactosidase expressed in 2273 quences, 2266 insect cells, 399 dihydrofolate reductase sequence het- transformation frequency Bal31 digestion erogeneity, 38 enhancing sequence, 368 barriers in SV40 chromatin, 604 E. coli, 38 Chinese hamster-human hybrid cell line Beadex genes exhibiting reduced expression af- leucine transport, 475 D. melanogaster, 1343 ter teratocarcinoma differentiation, Chinese hamster lung cells heldup-a gene. 1343 2142 cDNAs encoding dihydrofolate reduc- Beta interferon genes, amplified Cell cycle phases tases expression in CHO cells, 166 S. cerevisiae mother/daughter cell cy- E. coli, expression in, 38 BK virus-plasmid expression vector cles, 2529 nucleotide sequence, 38 E. coli, shuttle into, 1551 Cell cycle progression Chinese hamster ovary episomal persistence in human cells, HeLa cells asparaginyl-tRNA synthetase, 1939 1551 sodium butyrate, 829 Chinese hamster ovary cells B-lymphoid cell line, Abelson virus-trans- Cell proliferation aminopterin resistance, 1152 formed p53 protein, 276 aprt locus alterations, 1792 heavy-chain class switching, 2905 Swiss 3T3 cells, 276 A system switch region deletion, 2905 Cell surface P-glycoprotein amino acid transport in mutants, 799 Bovine papillomavirus DNA-mediated transformants of mouse gene regulation in mutants, 799 HLA gene, 340 cells, 500 deoxyribonucleoside triphosphate pool Brome mosaic virus Centromere V imbalances, 1792 cDNA cloning, 2876 S. cerevisiae, 86 dihydrofolate reductase gene amplifica- transcription, 2876 c-erb-A, c-erb-B tion, 69 Bromodeoxyuridine mutagenesis locations on different chicken chromo- diphthamide biosynthesis in mutant Syrian hamster cells, 2449 somes, 1627 cells, 642 c-fes excision repair capacity, 1152 mouse cells, 978 griseofulvin resistance mutation that af- c-fps fects the apparent molecular weight Caenorhabditis elegans location on a chicken microchromo- of a =200,000-dalton protein, 1761 Ceenorhabditis elegans some, 1627 human c-globin gene expression, 1469 collagen genes, 2389 Chicken actin genes, 2498 human beta interferon gene expression, sperm-specific gene family, 529 Chicken cells 166 Calcitonin/calcitonin gene-related peptide myosin alkali light chains lysosomes transcription unit D. melanogaster myosin alkali light- terminal endocytic compartment, 296 tissue-specific expression chain gene, 956 polyamine starvation prolongs S and G2 polyadenylation sites, 2151 Chicken c-src gene expression in COS phases, 915 Calcium-calmodulin cells, 846 pSV2gpt transformed, 1411 MAP-2 phosphorylation, 1175 Chicken embryo cells ricin internalization in mutant cells, Calmodulin biosynthesis canavanine treatment, 1534 1320 CEF phosphorylation of 42,000-dalton pro- RSV transformed normal, 883 teins on tyrosine in quiescent cells, tumorigenicity, 2639 virus transformed, 883 30 small circular DNA, 173 Calmodulin genes stress mRNA metabolism, 1534 translocations associated with dihydro- X. laevis, 507 Chicken embryo fibroblasts folate reductase gene amplification, Canavanine-treated chicken embryo cells calmodulin biosynthesis, 883 69 stress mRNA metabolism, 1534 influenza virus-infected cells Chlamydomonas reinhardi Candida tropicalis RNA polymerase II transcripts, 2198 chloroplast DNA methylation, 2103 peroxisomal proteins myosin light-chain kinase tubulin genes cloning of genes, 2136 immunoreactive levels, 2224 consensus sequence, 1115 Carbohydrate-binding protein 35 phosphotyrosine-specific protein phos- pseudopromoters, 1115 galactose-specific lectin, 1252 phatases, 1003 Chlamydomonas reinhardtii mouse tissues, 1252 tropomyosin polypeptides, multiple Chlamydomonas reinhardtii Carcinogenesis differential repression of transcription flagellar regeneration BHK cells, 1231 by RSV transformation, 1823 mRNA, 424 induction of a step normally associated Chicken embryo tibiae P-tubulin genes, 2686 with mutagenesis by nonmutagenic 64K collagen producer chondrocytes, Chloramphenicol acetyltransferase gene concentrations of 5-azacytidine, 1163 expression and encapsidation 1231 Chicken lens synemin, 1943 adeno-associated virus as a eucaryot- Cardiac actin Chicken myoblasts ic vector, 2072 mouse skeletal muscle cell differentia- collagen gene expression, 1483 Chloroplast DNA methylation tion, 1449 Chicken reticulocytes C. reinhardi gamete dedifferentiation, C4A4 repeats translational control 2103 0. fallax micronuclear genome, 2661 globin synthesis, 2437 Cholera toxin treatment Catalytic subunit HSP70 synthesis, 2437 RSV-transformed cells BHK cells, 1079 Chicken tk gene, 1769 tumorigenicity, 2639 VOL. 4, 1984 SUBJECT INDEX vii

Chondrocytes c-src Dihydrofolate reductase chicken embryo tibiae, 1163 mouse cells, 978 amplification, 69 64K collagen producer, 1163 c-src expression in COS cells, 846 Chinese hamster ovary cells, 69 Chromatin CYC7 gene expression sequence heterogeneity in CHL cells, 38 A. ambisexualis, 1198 S. cerevisiae, 2023 Dilute-coat-color locus of mice Bal3l digestion, 604 Cyclic AMP sequence analysis of d+u and d+Ha heat shock, 1198 MAP-2 phosphorylation, 1175 revertant alleles, 2899 structure mutant PC12 cells, 2091 Dimethyl sulfoxide SV40 insertion mutants, 1499 Cyclic AMP-dependent protein kinase DNA transfection, 1172 SV40, 604 BHK cells, 1079 Diphthamide biosynthesis CH1 splicing defect BHK cells that express v-src, 973 CHO cells resistant to diphtheria toxin, consensus splice signal in a mutant catalytic subunit, 1079 642 immunoglobulin gene, 1270 mouse S49 lymphoma cell system, 1086 DIRS-1 mouse myeloma mutants, 1270 regulatory subunit D. discoideum, 2207, 2332 C3H lOTI/2 cells charge-shift mutations, 1086 Discoidin I DNA sequences Cytochrome c pseudogenes D. discoideum mutant, 1035 5-azacytidine, 634 alternate mRNAs, 2279 Discoidin I genes Ciliary membrane vesicles Cytomegalovirus 94K protein D. discoideum, 671 T. thermophila conjugation, 681 expression in a DNA-transfected mouse genomic instability, 671 cis-Dominant mutations cell line, 2214 mobile elements, 671 S. cerevisiae DURI,2 gene expression, Cytoskeletal mRNAs d+' and d+Ha, 2899 947 lymphocyte activation, 1754 DNA Citrate synthase 5-methylcytosine, 985 derepression mouse cells transformed by RSV DNA, transcription, 247 1260 S. cerevisiae, 247 Dash RSV DNA used for transfection of Cloning Drosophila, 982 mouse cells, 1260 brome mosaic virus cDNA, 2876 Ddc S. cerevisiae, 985 human thymidine kinase gene, 2316 Drosophila, 1669 small circular c-myb intron-containing RNAs, 1669 CHO cells, 173 hemopoietic tissues of mice, 1206 2-Deoxygalactose DNA-binding protein location on an intermediate-size chicken S. cerevisiae synthesizing galactose-me- adenovirus, 1354 chromosome, 1627 tabolizing enzymes, 994 DNA damage c-myc 2-Deoxygalactose-resistant, galactokin- S. cerevisiae, 2356 leukemia/lymphoma, 1096 ase-deficient mutants of Chinese ham- transcript levels, 2356 cMyc or mRNA ster cells DNA-dependent mutagenesis translational efficiency in Burkitt lym- galK structural mutations, 2413 bromodeoxyuridine, 2449 phoma cells, 2235 Deoxyribonucleases Syrian hamster cells, 2449 2811 DNA families c-myc proteins, human, 2486 S. cerevisiae meiosis, Deoxyribonucleoside triphosphate pool mouse genome, 1561 Codon recognition imbalances DNA ligation S. frameshift cerevisiae suppression, aprt locus alterations, 1792 avian retrovirus, 240 2052 CHO cells, 1792 microinjection, 240 Cold sensitivity Dexamethasone transfection, 240 S. cerevisiae killer mutants, 761 MMTV, 1057 DNA-mediated drug-resistant mouse cell Collagen RNA polymerase II loading, 1057 transformants chondrocytes dhfr cell surface P-glycoprotein, 500 chicken embryo tibiae, 1163 amplification, 1050 double minute chromosomes, 500 gene expression mouse 3T6 cells, 1050 multiple drug resistance, 500 chicken myoblasts, 1483 UV radiation, 1050 DNA methylation genes DHFR gene, human 5-aza-2'-deoxycytidine-resistant vari- C. elegans, 2389 assignment to the qll -q22 region of ants of C3H lOTl/2 C18 cells, 2098 synthesis chromosome 5, 2010 cellular differentiation, 1800 control, 1843 Dictyostelium discoideum C. reinhardi chloroplasts, 2103 Conjugation Dictyostelium discoideum F9 teratocarcinoma cells cell surface interactions, 681 actin gene fusion, 2890 a-fetoprotein synthesis, 898 Tetrahymena ciliary membrane vesi- DIRS-1, 2332 heterochromatin, 599 cles, 681 discoidin I gene region HLA-DRo expression, 890 Copolymerization instability, 671 mealybugs, 599 cotransformation, 651 mobile elements, 671 thymidine kinase gene cluster, 611 plasmids in S. pombe, 651 discoidin I overproduction in mutant, DNA, micronuclear COS cells 1035 0. nova, 1725 chicken c-src gene expression, 846 gp80 glycoprotein sequences with autonomously replicat- Cotransformation mutations affecting, 514 ing activity in S. cerevisiae, 1725 plasmid copolymerization in S. pombe, spore coat protein gene DNA polymerases 651 DNA, 2273 S. cerevisiae meiosis, 2811 c-rasH p21 protein of EJ bladder carcino- thymidine requirement of mutants, 2784 DNA production ma transformation, 2890 MuLV, 151 metabolic turnover, 1647 Dictyostelium heat-shock promoter func- X-linked gene of mice, 151 Crithidia fasciculata tions in Saccharomyces cerevisiae, DNA replication alpha tubulin, 1182 591 adeno-associated virus, 1416 flagellar regeneration, 1182 Dictyostelium transposable element Alu family sequence replication tubulin heterogeneity, 779 DIRS-1, 2207 SV40 DNA synthesis, 1476 viii SUBJECT INDEX MOL. CELL. BIOL.

D. melanogaster, 1591 histone synthesis (noncoordinate) in Erythroleukemia (K562) cells octaribonucleotide primer, 1591 heat-shocked cells, 2676 3-globin gene, 2553 polyomavirus, 317 myosin alkali light-chain gene, 956 Escherichia coli SV40 insertion mutants, 1499 ribosomal protein genes, 2643 Ad2 ElA and EIB protein synthesis, SV40 irradiated with UV, 1286 ribosomal protein S14 homology, 2535 1427 SV40 large T-antigen point mutants, transcription factor binding, 2714 CHL cell cDNAs 1125 tropomyosin gene splicing dihydrofolate reductases, 38 T-antigen independence, 317 muscle tropomyosin isoforms, 2828 expression vector pBK TK-1, 1551 DNase I-hypersensitive sites Drug resistance ribosomal protein S6 homology, 2535 Drosophila heat shock genes CHO mutant cells supF gene D. melanogaster, 1853 DNA-mediated cotransfer of capacity error-prone mutagenesis detected in S. cerevisiae, 1853 into, 1152 mammalian cells, 2227 monkey genomic segment homologous DNA-mediated transformants of mouse E2 transcription unit to the regulatory region of SV40, cells, 500 adenovirus 5, 875 1635 Dsrc ElA-inducible promoter with an ele- DNase I sensitivity Drosophila, 982 ment that functions independently SV40 DNA, integrated, 559 DURI,2 of position or orientation, 875 DNA sequences expression, enhanced Excision repair altered 5'-flanking cis-dominant mutations, 947 CHO mutant cells S. cerevisiae tRNATYr gene expres- S. cerevisiae, 947 DNA-mediated cotransfer of capacity sion, 657 into, 1152 5-azacytidine, 634 Expression vector pBK TK-1 C3H 10T1/2 cells, 634 85K heat shock protein (hsp85), 2802 episomal persistence in human cells, homologous recombination in mammali- EIA genes 1551 an cells, 2253 adenovirus transcription control, 1293 S. cerevisiae sporulation, 142 ElA-inducible promoter Fatty acid-acylated proteins SV40 late RNA expression, 133 adenovirus 5 E2 transcription unit, 875 S. cerevisiae sec mutants, 688 X. laevis, 254 element that functions independently of Fatty acid acylation DNA synthesis position or orientation, 875 SV40 large T-angtigen control by insulin-like growth factor, ElA-like activity membrane interactions, 1542 1807 adenovirus genes, early, 867 a-Fetoprotein synthesis DNA transfection heat shock gene, control of, 867 DNA methylation, 898 dimethyl sulfoxide, 1172 Early gene expression F9 teratocarcinoma cells, 898 polycations, 1172 polyomavirus, 2594 induction, 898 DNA transfer Early region reacquisition Fibrinogen homologous recombination, 1020 mouse transformant containing defec- X. laevis, 2543 hygromycin B phosphotransferase as a tive SV40 DNA, 666 Fibroblasts, human marker, 2929 EIA synthesis in Escherichia coli transformation by adenovirus-SV40 re- mouse L cells, 1020 Ad2, 1427 combinants, 1653 dnc region plasmid pKHAO, 1427 Flagellar regeneration D. melanogaster, 358 EIB synthesis in Escherichia coli alpha tubulin, 1182 Double minute chromosomes Ad2, 1427 C. fasciculata, 1182 DNA-mediated transformants of mouse plasmid pKHBO, 1427 C. reinhardtii, 424 cells, 500 Ela gene products mRNA, 424 Double-stranded RNA adenovirus ElI promoter 5'-Flanking regions limit factor binding by heat inducibility, 181 transcription regulation, 1970 tRNA genes, 2714 killer toxins, 1747 EJ bladder carcinoma Fork progression M dsRNA human c-rasH p21 protein SV40 DNA replication unstable size, 1747 metabolic turnover, 1647 UV damaged, 1286 M2 replication EL2 cell line Friend leukemia virus inhibition by M1, 1747 transformation by oncogenes, 2925 leukemogenesis non-Mendelian inheritance, 181 Embryonal carcinoma cells myeloblastic malignant process, 216 replication by displacement of progeny heat shock proteins, 730 Friend x teratocarcinoma cell hybrids single strands, 1618 Endogenous intracisternal A-particle gene retrovirus gene expression, 923 S. cerevisiae, 92, 101, 181, 1618, 1747 long terminal repeat functions as a pro- F9 teratocarcinoma cells Drosophila moter, 2128 DNA methylation, 898 Dash, 982 Enhancer activity a-fetoprotein synthesis, 898 Dsrc, 982 Harvey sarcoma virus, 1664 Drosophila DOPA decarboxylase gene promoter dependence, 1664 intron-containing RNAs, 1669 SV40, 1664 GAL4 Drosophila melanogaster Enhancing sequence proteins coded for 268 Beadex, 1343 gene expression, 368 S. cerevisiae, 260 chicken myosin alkali light chains, 956 transformation frequency, 368 structure, 260 DNA replication env mRNA formation GAL7 octaribonucleotide primer, 1591 intron-contained sequences, 2289 expression on autonomous plasmids, DNase I-hypersensitive sites of heat M-MuLV, 2289 2062 shock genes, 1853 Epidermal growth factor S. cerevisiae, 2062 dnc region, 358 epidermal growth factor receptor me- Galactose/melibiose pathway genes 5'-flanking regions of a tRNAHiS gene tabolism in human fibroblasts, 1718 carbon-controlled regulation, 1521 and a tRNAHis pseudogene, 2714 Epidermal growth factor receptor GAL80, 1521 heat shock gene transformed into the A431 human epidermoid carcinoma S. cerevisiae, 1521 germ line, 2883 cells, 571 Galactose-metabolizing enzyme heldup-a gene, 1343 metabolism, 571 2-deoxygalactose toxicity, 994 VOL. 4, 1984 SUBJECT INDEX ix

S. cerevisiae, 994 Glucose-repressible genes cell cycle progression, 829 Galactose-specific lectin S. cerevisiae, 49, 54 histone gene expression, 2723 carbohydrate-binding protein 35, 1252 SNFI, 49, 54 hnRNA mouse tissues, 1252 Glutamate dehydrogenase (am) gene Ala sequences, 310 P-Galactosidase from Escherichia coli N. crassa transformation, 117 mitochondria expression in insect cells Glutamine-repressible gene products RNA-synthesizing system, 1605 A. californica nuclear polyhedrosis S. cerevisiae GLN3 function, 2758 mRNA metabolism, 538 virus vector, 399 Glutamine synthetase rDNA transcription, 221 GAL80 disruption S. cerevisiae, 2767 sodium butyrate, 829 galactose/melibiose pathway genes Glycoprotein G stress response, 1063 carbon-controlled regulation, 1521 recombinant middle T antigen, 282 12-O-tetradecanoyl-phorbol-13-acetate, S. cerevisiae, 1521 Glycoprotein gp8O 563 GALI-GALIO divergent promoter region D. discoideum, 514 tetraphenylphosphonium cation accu- S. cerevisiae, 2467 mutations affecting, 514 mulation, 199 USSG, 2467 Glycosylation, asparagine-linked transcription, 1063 GALI-GALIO promoter S. cerevisiae, 2381 transcription in AdV-infected cells lacZ fusions used to delimit regulatory Goat embryonic ,-globin pseudogene, treated with 12-O-tetradecanoyl- elements, 1985 2120 phorbol-13-acetate, 563 S. cerevisiae, 1440, 1985 gp8O glycoprotein translation, 1063 sequences that regulate, 1440 D. discoideum, 514 S-tubercidinylhomocysteine, 538 galK structural mutations mutations affecting, 514 p-tubulin gene transcription Chinese hamster cells, 2413 Griseofulvin resistance mutation stimulation by adenovirus S EIA, Gap filling apparent molecular weight of a 2792 SV40 DNA replication =200,000-dalton protein, 1761 heldup-a gene UV damaged, 1286 CHO cells, 1761 Beadex, 1343 Gene amplification Growth hormone, human D. melanogaster, 1343 CHO cells, methotrexate-resistant, 69 3T3 mouse cells Hematopoietic malignancies chromosomal translocations, 69 adipose conversion, 228 c-myc, 1096 dihydrofolate reductase gene, 69 Hemopoietic tissues Gene expression mice, 1206 Chinese hamster cells, 368 Harvey sarcoma virus proto-myb, 1206 cis-dominant mutations, 947 enhancer activity Hepatoma cells enhancing sequence, 368 promoter dependence, 1664 ornithine carbamoyl transferase human a-globin genes in CHO cells, Heat shock 5-azacytidine induced, 809 1469 A. ambisexualis, 1198 spontaneous, 809 rat hepatocytes, 1929 chromatin, 1198 Herpes simplex virus S. cerevisiae DURI,2 gene, 947 nuclear protein phosphorylation, 1198 AUG codon of thymidine kinase gene sea urchin actin genes Heat shock genes inserted in a retrovirus vector, 743 constitutive, 840 control enhanced reactivation and mutagenesis embryo specific, 840 ElA-like activity, 867 in normal human and xeroderma muscle specific, 840 D. melanogaster, 1853 pigmentosum cells, 2341 transformation frequency, 368 fused to 3-galactosidase late promoter Gene reconstruction S. cerevisiae, 2573 transactivation, 544 homologous recombination between hypersensitivity, 1853 thymidine kinase synthesized in bacte- thymidine kinase gene fragments S. cerevisiae, 1853 ria inserted into a mouse cell genome, 70K transfer to tissue culture cells, 1644 852 regulation, 1454 Heterochromatin Globin cell-free transcription S. cerevisiae, 1454 DNA methylation level, 599 mouse erythroleukemia cells, 17 transformed mealybugs, 599 ,3-Globin gene Drosophila germ line, 2883 Heterogeneous nuclear RNA erythroleukemia (K562) cells, 2553 Heat shock polypeptides, 70-kilodalton Alu family sequences, 310 1-Globin genes cDNA sequences, 1785 HeLa cells, 310 X. Iaevis rainbow trout, 1785 KB cells, 310 tadpole and adult genes injected into Heat-shock promoter functions L cells, 310 eggs, 567 Dictyostelium, 591 Heterogeneous nuclear RNA-protein com- a-Globin genes, human S. cerevisiae, 591 plexes CHO cells, 1469 Heat shock proteins monoclonal antibodies, 1104 Globin gene transcription embryonal carcinoma cells, 730 Hexanucleotide AAUAAA X. laevis oocytes and unfertilized eggs, mouse early embryonic cells, 730 polyadenylation site cleavage, 1460 2109 Heat shock response sequences on 3' side, 1460 P-Globin pseudogene, goat embryonic, rRNA degradation, 2170 H3 histone mRNA metabolism 2120 T. thermophila, starved, 2170 cell cycle regulation, 123 Globin synthesis Heavy-chain class switching HIS4 chicken reticulocytes, 2437 Abelson virus-transformed B-lymphoid S. cerevisiae, 1326 Glucoamylase gene cell line, 2905 Histone gene A. awamori, 2306 Heavy metals regulation Glucocorticoid receptors metallothionein-I mRNA induction translation, 2723 down-regulation, 449 mouse hepatocyte cell line, 484 transcription mouse lymphoma cell variants, 449 HeLa cells mouse myeloma cells, 351 Glucose alpha gene expression, 829 rate changes, 351 transcription of S. cerevisiae nuclear amino acid analog exposure Histone mRNA genes that encode mitochondrial transcription, 1063 level changes, 351 components, 939 translation, 1063 mammalian cell cycle, 2364 x SUBJECT INDEX MOL. CELL. BIOL.

mouse myeloma cells, 351 Human epidermoid carcinoma cells (A431) Insect cells protein synthesis inhibition, 2082 epidermal growth factor, 571 E. coli ,B-galactosidase expression Histones Human fibroblasts A. californica nuclear polyhedrosis phosphorylation, 1186 epidermal growth factor receptor me- virus vector, 399 Histone synthesis, noncoordinate tabolism Insulin-like growth factor Drosophila cells, 2676 epidermal growth factor, 1718 DNA synthesis HIS4 transcription 12-O-tetradecanoylphorbol- 13-ace- post-transcriptional control, 1807 S. cerevisiae, 1246 tate, 1718 int-l Ty insertions, 1246 transformation by adenovirus-SV40 re- cloning and chromosomal assignment of HLA-DRa expression combinants, 1653 human homolog, 2532 DNA methylation, 890 Human genes for U2 small nuclear RNA Intercalating agents HLA gene expression tandem repeats, 492 RNA polymerase I promoter selection, bovine papillomavirus vector, 340 Human growth hormone 2851 mouse cells, 340 mouse cells, 3T3 X. laevis, 2851 HMLa adipose conversion, 228 Intermediate filaments mating type control, 203 Human histone genes disruption in SV40-infected monkey S. cerevisiae, 203 adenovirus, 1363 kidney cells, 1880 Homologous recombination Human homolog of int-1 Internal AUG codon of herpes simplex DNA transfer into mouse L cells, 1020 chromosomal assignment, 2532 thymidine kinase gene gene reconstruction, 852 cloning, 2532 retrovirus vector, 743 homology required, 2253 Human lymphocytes int-1, int-2 rat cells, 1141 mitogen-inducible gene, 2540 mouse mammary tumor virus, 375 SV40 T-antigen genes, 1141 tumor promoter, 2540 Intracisternal A particle elements thymidine kinase gene fragments insert- Human mitochondria transposition into immunoglobulin kap- ed into a mouse cell genome, 852 RNA-synthesizing system, 1605 pa-chain gene, 2565 Hormonal regulation of transformation Human neuroblastoma cells Intron-contained sequences phenotype amplified domain, 2370 M-MuLV env mRNA formation, 2289 SV40-transformed rat embryonic pre- Human oncogenes Intron-containing RNAs adipose cell lines, 712 mcf2, 1695 Drosophila DOPA decarboxylase gene, Horseradish peroxidase, pinocytized mcf3, 1695 1669 CHO lysosomes, 296 N-ras, 1695 Introns excised from immunoglobulin pre- hsp85 tumorigenicity assay, 1695 mRNAs, 2017 quantitation and localization, 2802 Human papovavirus replication Intron site hsp7o cDNAs from trout cells, 1785 transformed human embryonic kidney human smooth muscle actin gene, 1073 HSP70 synthesis cells, 379 Invertase 3-galactosidase hybrid protein chicken reticulocytes, 2437 Human RNA polymerase II transport Human adenosine deaminase mRNAs, premature termination in the adenovirus C. cerevisiae endoplasmic reticulum, 1712 major late transcriptional unit, 2031 2347 Human a-globin genes Human smooth muscle actin gene with a Invertase mRNAs CHO cells, 1469 unique intron site, 1073 regulation, 1682 Human argininosuccinate synthetase gene Human thymidine kinase gene S. cerevisiae, 1682 alternative mRNA splicing, 1978 cloning, 2316 Iodoacetate Human 1-actin genes, 1961 nucleotide sequence, 2316 metallothionein-I mRNA induction Human beta interferon genes, amplified Hygromycin B phosphotransferase mouse hepatocyte cell line, 484 CHO cells, 166 selectable marker for DNA transfer ex- Iso-2-cytochrome c Human cell gene transfer periments, 2929 S. cerevisiae CYC7-H2 mutants amphotropic retrovirus vector system, Hypoxanthine-guanine phosphoribosyl- Tyl, 1393 1730 transferase Human cells gene amplification in chromosome-me- adenovirus gene, 1354 diated gene transferents, 618 K-activating element enhanced reactivation and mutagenesis mapping, 1042 of HSV, 2341 Kappa-chain gene IFN-1 Serl7 binding, 2745 insertional mutagenesis by intracisternal mutator phenotype toward parvovirus IFN-p Serl binding to human cells, 2745 A particle elements, 2565 H-1, 324 Immunoglobulin gene activator KB cells transfected DNA is mutated, 1951 mapping, 1042 hnRNA transformation by UV-irradiated pSV2 Immunoglobulin kappa-chain gene Ala sequences, 310 plasmids, 1169 intracisternal A particle element, 2565 Kinase mutations Human cellular Kirsten ras genes Immunoglobulin pre-mRNAs mouse S49 lymphoma cell system, 1086 localization on chromosomes 6 and 12, introns, 2017 Ki-ras2 oncogene 989 Immunoglobulin RNA splicing mutants, proto-oncogene, 1577 Human-Chinese hamster hybrid cell line 1270 Kirsten ras genes (human cellular) leucine transport, 475 Influenza virus-infected cells localization on chromosomes 6 and 12, Human c-myc proteins RNA polymerase II transcripts, 2198 989 expression in neoplastic cells, 2486 Influenza virus neuraminidase Human colon carcinoma Ki-ras2 onco- glycosylation, 8 La antigen gene N-terminal hydrophobic region, 8 3'-oligouridylate tail of a small RNA, proto-oncogene, 1577 surface expression, 8 1134 Human embryo kidney cell lines Initiation codons, non-AUG L-A-HN adenovirus type 12 transformed, 110 S. cerevisiae, 1191 M2 dsRNA exclusion in S. cerevisiae Human embryonic kidney cells IN02, IN04 superkiller mutants, 761 papovavirus replication, 379 pleiotropic regulatory genes, 2479 Laminin carbohydrate transformation, 379 S. cerevisiae, 2479 functional role, 1 VOL. 4, 1984 SUBJECT INDEX xi Large T antigen coli, 2227 thymic lymphomas, 997 expressed in mouse embryonal carcino- MAP-2 phosphorylation Moloney murine leukemia virus ma cell hybrids, 1657 calcium-calmodulin, 1175 env mRNA formation Large T-antigen-coding sequence cAMP, 1175 intron-contained sequences, 2289 SV40, 1661 Mating type control p53 gene expression, 1402 transformation, 1661 mutation at X of HMLcx, 203 Monkey cells Large T antigen-producing mouse cell S. cerevisiae, 203 mouse p53 cellular tumor antigen lines mcf2, mcf3 expression in, 2180 replication of polyomavirus-plasmid re- detection by tumorigenicity assay, 1695 SV40 T antigen in nuclear matrix, 1384 combinants, 2406 M double-stranded killer plasmids transfected DNA is mutated, 1951 Late herpes simplex virus promoter S. cerevisiae, 2818 Monkey genomic segment homologous to transactivation, 544 virus-like particle capsid proteins, 2818 the regulator region of simian virus 40 Late polyomavirus nuclear RNA M double-stranded RNA DNase I-hypersensitive sites, 1635 polyadenylation, 722 S. cerevisiae, 1747 Monkey kidney cells Late 16S mRNA unstable size, 1747 SV40 infection ribosome number, 813 M2 double-stranded RNA exclusion by intermediate filaments, 1880 SV40, 813 L-A-HN vimentin synthesis, 1880 L cells S. cerevisiae killer mutants, 761 Monoclonal antibodies hnRNA Mealybugs avian myb products, 2843 Ala sequences, 310 DNA methylation level, 599 hnRNA-protein complexes, 1104 L double-stranded RNAs, multiple heterochromatin, 599 Mouse cells encapsidation, 92 Meiosis actin gene S. cerevisiae, 92 S. cerevisiae mRNA, 695 skeletal muscle cell differentiation, Lectin MEL] transcript 1449 carbohydrate-binding protein 35, 1252 S. cerevisiae, 1238 bovine papillomavirus-linked HLA mouse tissues, 1252 Membrane interactions gene, 340 Lectin activation of lymphocytes fatty acid acylation, 1542 cAMP-dependent protein kinase actin mRNA levels, 1754 protein sequences, 1542 regulatory subunit mutations, 1086 tubulin mRNA levels, 1754 SV40 large T-antigen, 1542 cardiac actin Leishmania donovani Messenger ribonucleoproteins skeletal muscle cell differentiation, nucleoside transport, 1013 transcriptional inhibitors, 415 1449 Leishmania tropica Metallothionein I and II genes c-fes, 978 ,-tubulin genes, 1372 Chinese hamster chromosome 3, 2932 chromosome 15 Leucine transport mouse, 1221 cellular DNA region involved in in- Chinese hamster-human hybrid cell line, Metallothionein-I mRNA induction duction of thymic lymphomas, 475 gratuitous inducers, 484 997 Leukemia/lymphoma heavy metals, 484 c-src, 978 c-myc, 1096 iodoacetate, 484 cytomegalovirus 94K protein, 2214 Leukemogenesis mouse hepatocyte cell line, 484 dhfr gene amplification, 1050 myeloblastic malignant process, 216 Metallothionein inducibility differentiation Ligation of DNA Chinese hamster cell cycle, 2243 DNA methylation, 1800 avian retrovirus, 240 Methotrexate resistance DNA methylation in 5-aza-2'-deoxycyti- microinjection, 240 mouse cells, 1050 dine-resistant variants of C3H transfection, 240 UV radiation, 1050 lOTl/2 C18 cells, 2098 Long terminal repeat functioning as a pro- 5-Methylcytosine DNA synthesis moter S. cerevisiae DNA, 985 control by insulin-like growth factor, endogenous intracisternal A-particle Mg2+ 1807 gene, 2128 U1 and U2 snRNPs, 1890 early-region reacquisition by transform- LSTRA cells Microinjection ant containing defective SV40 tyrosine protein kinase activity avian retrovirus, 240 DNA, 666 protein p56, 2705 DNA ligation embryonal carcinoma cell hybrids Lymphocytes Micronuclear DNA of Oxytricha nova SV40 large T antigen expression, 1657 lectin activation sequences with autonomously replicat- homologous recombination between tk actin mRNA levels, 1754 ing activity in S. cerevisiae, 1725 gene fragments, 852 tubulin mRNA levels, 1754 Micronuclear genome of Oxytricha fallax methotrexate resistance, 1050 Lysis receptosomes C4A4 repeats, 2661 mutant ts2O adenovirus, 1528 Middle-T antigen characterization, 1815 penton base, 1528 polyomavirus, 1334 correction of defect, 1815 Pseudomonas exotoxin toxicity, 1528 tyrosine phosphorylation sites, 1334 p53, 383 Lysosomes Middle T antigen, recombinant p53 cellular tumor antigen CHO cells, 2% carboxyl terminus of VSV glycoprotein UV stimulation, 1689 terminal endocytic compartment, 2% G, 282 retroviral DNA synthesis, 151 Minute virus of mice RSV DNA, 1260 Macronuclear DNAs high-frequency deletions in DNA medi- S49 0. fallax, 931 ated by short direct repeats, 2239 protein synthesis inhibition stabilizes sequence block, 931 Mitochondria, human histone mRNA, 2082 Major urinary protein genes expression RNA-synthesizing system, 1605 teratocarcinoma differentiation mRNAs, 2259 Mitochondrial components gene regulation, 2142 Mammalian cell cycle glucose, 939 thymic lymphomas, 997 histone mRNA levels, 2364 S. cerevisiae, 939 thymidine kinase transferred to Ltk- Mammalian cells transcription of genes that encode, 939 cells by PEG-mediated fusion with error-prone mutagenesis detected by a Mlvi-2 protoplasts prepared from bacteria shuttle vector containing supF ofE. mouse chromosome 15, 997 containing induced levels of Tk, xii SUBJECT INDEX MOL . CELL . BIOL .

1644 1572 influenza virus, 8 transfected DNA expression in Ltk Mouse tissues N-terminal hydrophobic region, 8 cells, 1641 carbohydrate-binding protein 35, 1252 surface expression, 8 transfected DNA is mutated, 1951 lectin, 1252 Neuroblastoma cells transfection, 1260 M2 replication amplified domain, 2370 UV radiation, 1050 M1 inhibition, 1747 human, 2370 Mouse cells, 3T3 S. cerevisiae, 1747 Neuronal microtubule skeletons adipose conversion mRNA direct isolation, 371 human growth hormone, 228 ,B-tubulin Neurospora crassa Mouse cell transformants, DNA-mediated rat brain development, 1313 Neurospora crassa cell surface P-glycoprotein, 500 C. reinhardtii flagellar regeneration, 424 am, 117 double minute chromosomes, 500 major urinary protein genes in mice, transformation, 117 multiple drug resistance, 500 2259 transformation with recombinant plas- Mouse dihydrofolate reductase gene S. cerevisiae mids containing am, 2041 transcription termination, 2921 meiosis, 695 NIH 3T3 cells Mouse early embryonic cells sporulation, 695 transformation heat shock proteins, 730 X. laevis fibrinogen, 2543 endogenous murine leukemia pro- Mouse erythroleukemia cells mRNA derepression virus, 2247 globin cell-free transcription, 17 S. cerevisiae amino acid biosynthesis, MCF-7 DNA, 2247 Mouse genome 520 N-ras DNA families, most highly repeated dis- mRNA metabolism detection by tumorigenicity assay, 1695 persed, 1561 chicken embryo cells, canavanine-treat- Nuclear proteins Mouse hemopoietic tissue ed, 1534 A. ambisexualis, 1198 proto-myb, 1206 HeLa cells, 538 heat shock, 1198 Mouse Hepa-l cells S-tubercidinylhomocysteine, 538 phosphorylation, 1198 aryl hydrocarbon hydroxylase-deficient undermethylation, 538 Nuclease Bal3l digestion mutants mRNA synthesis barriers in SV40 chromatin, 604 revertants, 1597 adenovirus EIB, 966 Nucleolar dominance Mouse hepatocyte cell line control by shift in RNA splice sites, 966 mouse > human hybrid cells, 1306 metallothionein-I mRNA induction mRNA translation rDNA transcription factor, 1306 gratuitous inducers, 484 adenovirus VA RNA&, 736 Nucleoside transport heavy metals, 484 Murine embryonal carcinoma cells L. donovani, 1013 iodoacetate, 484 polyomavirus DNA replication Nucleotide sequence Mouse H3 histone mRNA metabolism T-antigen independence, 317 SV40 late 16S mRNA, 813 cell cycle regulation, 123 Murine leukemia provirus Mouse L cells NIH 3T3 transformation, 2247 Octaribonucleotide primer DNA transfer, 1020 Murine leukemia virus D. melanogaster DNA repilcation, 1591 homologous recombination, 1020 DNA production, 151 Oncogenes rDNA transcription, 221 X-linked gene of mice, 151 mcJ2, 1695 Mouse lymphoma cell lines Murine renin genes, 2321 mcf3, 1695 transferrin receptor mutation, 1675 Murine retrovirus gene expression N-ras, 1695 Mouse lymphoma cell variants shutdown in murine cell lines, 908 tumorigenicity assay, 1695 glucocorticoid receptors Muscle tropomyosin isoforms Oncogenes c-erb-A and c-erb-B located on down-regulation, 449 D. melanogaster, 2828 different chicken chromosomes Mouse mammary tumorigenesis tropomyosin gene splicing, 2828 transduction into the same retroviral human homolog of int-i, 2532 Mutagenesis genome, 1627 Mouse mammary tumor virus indirect induction, 324 Oncogene transcription dexamethasone, 1057 Myeloblast differentiation, 2587 rat liver, regeneration, 1493 integration regions int-I and int-2, 375 Myeloblastic malignant process Oncogenic transformation RNA polymerase II loading, 1057 leukemogenesis, 216 SV40 large T-antigen point mutants, Mouse metallothionein I and II genes, model that specifies three steps, 216 1125 1221 Myosin alkali light-chain gene Ornithine carbamoyl transferase Mouse myeloma cells chicken myosin alkali light chains, 956 hepatoma cells, 809 histone gene transcription rate, 351 D. melanogaster, 956 reexpression histone mRNA levels, 351 Myosin light-chain kinase 5-azacytidine induced, 809 Mouse myeloma mutants immunoreactive levels in CEF, 2224 spontaneous, 809 immunoglobulin RNA splicing, 1270 Myristic acid Oxytricha fallax Mouse p53 cellular tumor antigen attachment to RSV transforming pro- Oxytricha fallax gene, location of, 1638 tein, 2697 C4A4 repeats in micronuclear genome, pseudogene, location of, 1638 Myxamoeba-flagellate transformation of 2661 Mouse p53 cellular tumor antigen ex- Physarum polycephalum macronuclear DNAs pressed in monkey cells, 2180 RNA, 1706 931 Mouse rDNA spacer tubulin proteins, 1706 sequence block, transcription, 822 Mouse rDNA transfection, 576 p94 Mouse ribosomal protein L30 gene family Nascent transcripts of simian virus 40 gene expression expressed gene, 2518 S1 mapping, 625 teratocarcinoma-derived stem cells processed pseudogenes, 2518 Neoplastic cells versus differentiated cells, 2428 Mouse 3T3 cells human c-myc proteins, 2486 Papovavirus replication p53 degradation Neural cell-specific P-tubulin mRNAs transformed human embryonic kidney energy requirement, 442 rat brain development, 1313 cells, 379 SV40 transformed Neuraminidase Paramecium tetraurelia reduced growth factor dependency, glycosylation, 8 surface antigen expression VOL. 4, 1984 SUBJECT INDEX xiii

mutations affecting, 1583 Plasminogen activator activity injection into Xenopus oocytes Parvovirus H-I modulation by cocultivation, 160 progesterone-induced meiotic matu- transfection Platelet-derived growth factor ration, 1631 human cells, 324 SV40-transformed 3T3 cells, 1572 ribosomal protein S6 phosphorylation, rat cells, 324 Pleiotropic regulatory genes 1631 PC12 cAMP mutant cells, 2091 IN02, IN04, 2479 RSV-transformed cell lysates, 1213 p53 cellular tumor antigen S. cerevisiae, 2479 S. lacustris, 1179 UV stimulation, 1689 p53 mRNA, aberrant 34K substrate, 77 p53 cellular tumor antigen, mouse Abelson murine leukemia virus-trans- Progesterone-induced meiotic maturation gene, location of, 1638 formed cells, 552 Xenopus oocytes pseudogene, location of, 1638 Polyadenylate pp60v-src injected into, 1637 p53 gene S. cerevisiae, 101 Promoter dependence of enhancer activi- expression inactivated by insertion of Polyadenylation ty, 1664 Mo-MuLV-like DNA sequences, cleavage Promoter region 1402 hexanucleotide AAUAAA, 1460 C. reinhardi tubulin genes, 1115 Pea chloroplast DNA polyomavirus nuclear RNA, late, 722 Promoter-specific binding factors PGII gene, 2556 Polyadenylation sites rDNA transcription, 221 Penton base calcitonin/calcitonin gene-related pep- Protein adenovirus lysis receptosomes, 1528 tide transcription unit 42,000 dalton Pseudomonas exotoxin toxicity, 1528 tissue-specific expression, 2151 phosphorylation, 30 Peroxisomal proteins Polyamine starvation pp6 v-src cloning of genes, 2136 CHO cells substrate of, 77 C. tropicalis, 2136 S and G2 phases, 915 6K, 77 PGII gene Polycations 34K, 77 pea chloroplast DNA, 2556 DNA transfection, 1172 Protein kinase Phosphorylation Poly(dT-dG) * poly(dC-dA) sequence BHK cells, 1079 calcium-calmodulin, 1175 characterization, 2610 BHK cells infected with RSV, 973 cAMP, 1175 enhanced gene expression, 2622 cAMP dependent 42,000-dalton proteins on tyrosine in Polyoma middle T antigen catalytic subunit, 1079 quiescent chick cells, 30 Polyoma middle-T antigen regulatory subunit charge-shift muta- histones in cells treated with hypertonic malignant phenotype expression, 755 tions, 1086 and acidic media, 1186 N-terminal amino acid sequences mouse S49 lymphoma cell system, 1086 MAP-2, 1175 cell transformation, 817 polyoma middle-T antigen nuclear proteins protein kinase activity, 817 N-terminal amino acid sequences, 817 A. ambisexualis, 1198 Polyoma small T antigen Protein kinase activity heat shock, 1198 cell surface uncoupling, 2774 immune complexes of SV40 large T- polyomavirus middle-T antigen, 1334 cytoskeletal changes, 2774 antigen and transformation-associ- ribosomal protein S6 Polyoma virus ated cellular p53 protein, 232 pp6O-src injected into Xenopus oo- Polyomavirus Protein p56 cytes, 1631 DNA replication tyrosine protein kinase activity in SV40 tumor antigens, 232 murine embryonal carcinoma cells LSTRA cells, 2705 34K protein, 212 317 Protein phosphatases Phosphotyrosine-specific protein phos- T-antigen independence, 317 CEF, 1003 phatases early gene expression, 2594 phosphotyrosine specific, 1003 CEF, 1003 middle-T phosphorylation sites, 1334 Proteins Photoreactivation tumorigenicity, 755 S. cerevisiae GAL4 coding for, 268 S. cerevisiae PHRI gene, 1864 Polyomavirus nuclear RNA, late Protein sequences PHR1 polyadenylation, 722 SV40 large T antigen S. cerevisiae, 1864 Polyomavirus-plasmid recombinants membrane interactions, 1542 Physarum polycephalum large T antigen-producing cell lines, Protein synthesis myxamoeba-flagellate transformation 2406 histone mRNA stabilization, 2082 RNA, 1706 p21 protein S49 mouse lymphoma cells, 2082 tubulin proteins, 1706 S. cerevisiae related proteins, 23 Proto-myb Plasmid pKHAO p53 protein hemopoietic tissues of mice, 1206 Ad2 cell proliferation, 276 Protoplast fusion EIA synthesis in E. coli, 1427 energy requirement for degradation, 442 cloned DNA transferred into human Plasmid pKHBO mouse cells, 383 diploid cells, 2549 Ad2 protein kinase activities in SV40 large T- SV40 T antigen, 2549 EIB synthesis in E. coli, 1427 antigen immune complexes, 232 Pseudomonas exotoxin Plasmid pSV2 pp6(Src toxicity human cell transformation, 1169 amino acid alterations, 862 penton base of adenovirus, 1528 UV irradiation, 1169 tyrosine protein kinase activity, 862 Plasmid pSV2gpt pp60src-associated kinase activity cell transformation, 1834 deletion mutations in transformed CHO phosphorylation of the 34K protein, 212 membrane association, 1834 cells, 1411 tumorigenicity in vole cells, 212 myristylation, 1834 Plasmid recombination pp60Src proteins, size-variant N terminus, 1834 S. cerevisiae, 195 adhesion plaque interaction, 454 PUT2 Plasmid R388-encoded type II dihydrofo- cell transformation, 454 S. cerevisiae, 2837 late reductase marker in S. cerevisiae, recovered ASVs, 454 407 subcellular localization, 454 Rabbit liver Plasmid TLC-I pp6ov-src ribosomal protein S12 homology, 2535 recombinational instability, 195 functional domains as revealed by anal- RAD2 S. cerevisiae, 195 ysis of ts RSV mutants, 1508 S. cerevisiae, 290 xiv SUBJECT INDEX MOL. CELL. BIOL.

RAD52 shutdown in murine cell lines, 908 transformed cell lysates S. cerevisiae, 2735 vector modified pp60v-src, 1213 RAD1 gene v-src location, 2653 tropomyosin polypeptides in CEF cloning, 2161 Ribosomal DNA transcription factor differential repression of transcrip- nucleotide sequence analysis, 2161 nucleolar dominance in mouse>human tion, 1823 S. cerevisiae, 2161 hybrid cells, 1306 RPSIA Rare transcripts of rat brain Ribosomal protein S. cerevisiae, 1871 cloning of DNA corresponding to, 2187 genes RPSIB ras (human cellular Kirsten) genes D. melanogaster, 2643 S. cerevisiae, 1871 localization on chromosomes 6 and 12, homology rRNA degradation 989 B. subtilis (S6), 2535 T. thermophila, starved, 2170 ras mRNA D. melanogaster (S14), 2535 S. cerevisiae, 2298 E. coli (S6), 2535 ras-related proteins rabbit liver (S12), 2535 S. cerevisiae, 23 S. cerevisiae (S25), 2535 Rat brain protein 51 Saccharomyces cerevisiae rare transcripts, 2187 S. cerevisiae RPSJB and RP51A Saccharomyces cerevisiae 1-tubulin mRNA, 1313 genes, 1871 acid phosphatase secretion, 2668 Rat cells protein S6 amino acid biosynthesis homologous recombination phosphorylation, 1631 mRNA derepression, 520 SV40 T antigen genes, 1141 pp60v-src injected into Xenopus oo- temporal analysis, 520 mutator phenotype toward parvovirus cytes, 1631 a2 product, 2420 H-1, 324 Ribosomes ARS activity in 0. nova micronuclear PC12 cAMP mutant cells, 2091 initiation codons, non-AUG, 1191 DNA, 1725 Rat cell line EL2 S. cerevisiae, 1191 ARSI sequence, 2455 transformation by oncogenes, 2925 Ricin internalization asparagine-linked glycosylation, 2381 Rat cytochrome c pseudogenes CHO mutant cells, 1320 carbon source and Ty-associated gene alternate mRNAs, 2279 RNA activation, 61 Rat embryonic preadipose cell lines, simi- adenovirus, 1134 CDC8, 583 an virus 40-transformed La antigen binding site, 1134 cell cycle phases in unequal mother/ hormonal regulation of transformation myxamoeba-flagellate transformation of daughter cell cycles, 2529 phenotype, 712 P. polycephalum, 1706 cell fusion, 771 Rat hepatocytes P. polycephalum myxamoeba-flagellate centromere V, 86 posttranscription modulation of gene transformation, 1706 citrate synthase derepression expression, 1929 RNA polymerase transcription, 247 Rat liver U. maydis virions, 188 codon recognition during frameshift oncogene transcription, 1493 RNA polymerase I promoter selection suppression, 2052 Rat stress proteins intercalating agents, 2851 cold sensitivity, 761 nuclear localization, 468 X. laevis, 2851 CYC7 gene expression, 2023 phosphorylation, 468 RNA polymerase I transcription CYC7-H2 mutant R * dhfr HeLa cells, 221 iso-2-cytochrome c production, 1393 S. cerevisiae, 407 mouse L cells, 221 Tyl, 1393 rDNA spacer promoter-specific binding factors, 221 2-deoxygalactose toxicity, 994 mouse, 822 RNA polymerase II Dictyostelium heat-shock promoter transcription, 822 dexamethasone, 1057 functions, 591 rDNA transcription loading on MMTV, 1057 DNA HeLa cells, 221 RNA polymerase II transcripts 5-methylcytosine, 985 mouse L cells, 221 influenza virus-infected cells, 2198 DNA damage promoter-specific binding factors, 221 RNA2, RNA3, RNAII transcript levels, 2356 rDNA transfection, mouse, 576 S. cerevisiae, 2396 DNase I-hypersensitive sites of heat Recombinant middle T antigen RNA splicing shock genes, 1853 carboxyl terminus of VSV glycoprotein adenovirus EIB mRNA synthesis, 966 dsRNA G, 282 RNA-synthesizing system heat inducibility, 181 Recombination human mitochondria, 1605 killer toxins, 1747 DNA transfer into mouse L cells, 1020 Rouse sarcoma virus-transformed cells non-Mendelian inheritance, 181 S. cerevisiae meiosis, 2811 cholera toxin treatment, 2639 replication, 1618 Recovered avian sarcoma viruses Rous sarcoma cells DUR1,2 expression pp60rc proteins, size-variant BHK cells cis-dominant mutations, 947 localization, 454 protein kinase activities, 973 endoplasmic reticulum Ren-1, Ren-2 expression Rous sarcoma virus invertase ,B-galactosidase hybrid pro- 5'-proximal flanking regions, 2321 molecular forms of DNA used for trans- tein, 2347 Replication origins fection of mouse cells, 1260 fatty acid-acylated proteins in sec mu- Ad5, 302 mouse cell transfection, 1260 tants, 688 rescue, 302 mutation of a termination codon affects GAL4 Retroviral DNA synthesis src termination, 1738 proteins coded for, 268 ts mouse cells, 151 myristic acid attachment to transform- structure, 260 Retrovirus ing protein, 2697 galactose/melibiose pathway genes AUG codon of an HSV thymidine ki- pp6OSrc carbon-controlled regulation, 1521 nase gene inserted into, 743 amino acid alterations, 862 galactose-metabolizing enzyme, 994 chicken tk gene inserted into, 743 tyrosine protein kinase activity, 862 GAL80 disruption, 1521 gene expression pp60v-src functional domains, 1508 GALI-GALJO divergent promoter re- Friend x teratocarcinoma cell hy- src expression in avian macrophages, gion brids, 923 1420 UASG, 2467 VOL. 4, 1984 SUBJECT INDEX xv

GAL1-GAL10 promoter RP51A, 1871 late promoter, major lacZ fusions used to delimit regula- RPSIB, 1871 transcription, 133 tory elements of, 1985 SAD, 1278 upstream DNA sequence, 133 GALJ-GALJO promoter regulation, 1440 sec mutants, 688 late 16S mRNA ribosome number, 813 GAL7 gene expression on autonomous SNFI, 49, 54 monkey genomic segment homologous plasmids, 2062 sporulation, 695 to the regulatory region, 1635 GLN3 function, 2758 DNA sequences, 142 monkey kidney cells glutamine-repressible gene products, STE6 expression, 2420 intermediate filaments, 1880 2758 SUC2 derepression, 2750 vimentin synthesis, 1880 glutamine synthetase, 2767 superkiller mutations, 761 mouse 3T3 cells, transformed heat shock gene fused to ,B-galacto- thymidylate synthase, 2858 reduced growth factor dependency, sidase, 2573 transcription termination, 1515 1572 heat shock gene (70K) transformation, 771 mouse transformant, 666 regulation, 1454 transposable element-associated gene nascent transcripts HIS4, 1326 activation S mapping, 625 HIS4 transcription, 1246 carbon source, 61 rat cells, 1141 HMLa tRNATYr gene expression T antigen mutation at X. 203 altered 5'-flanking sequences, 657 transfer of cloned DNA into human initiation codons, non-AUG, 1191 Ty, 61, 329, 1246 diploid cells, 2549 IN02, IN04 Tyl, 1393 T antigen in nuclear matrix of monkey pleiotropic regulatory genes, 2479 Ty movement by gene conversion, 703 cells, 1384 invertase mRNAs virus-like particle capsid proteins, 2818 Simian virus 40-adenovirus recombinant cytoplasmic, 1682 SAD human fibroblast transformation, 1653 regulation, 1682 S. cerevisiae, 1278 Simian virus 40 DNA, integrated secreted, 1682 Schizosaccharomyces pombe DNase I sensitivity, 559 iso-2-cytochrome c production, 1393 cotransformation by copolymerization Simian virus 40-transformed rat embryon- killer virus transcripts of plasmids, 651 ic preadipose cell lines polyadenylate tracts, 101 Sea urchin actin genes transformation phenotype L dsRNAs, multiple constitutive expression, 840 hormonal regulation, 712 encapsidation, 92 embryo-specific expression, 840 Small nuclear RNA mating type control, 203 muscle-specific expression, 840 U2 RNA M double-stranded killer plasmids, 2818 sea urchin, 840 tandem repeats, 492 M dsRNA sec mutants Small polydisperse DNA transcriptionally encoded polyadenyl- fatty acid-acylated proteins, 688 CHO cells, 173 ate, 101 S. cerevisiae, 688 Sl mapping unstable size, 1747 Shuttle vector plasmid nascent transcripts of SV40, 625 M2 dsRNA exclusion, 761 mutagenesis in mammalian cells, 435 SNFI meiosis, 695 Shuttle vector sequences glucose-repressible genes, 49, 54 deoxyribonucleases, 2811 mutation frequency, 2266 S. cerevisiae, 49, 54 DNA polymerases, 2811 Simian virus 40 Sodium butyrate recombination, 2811 African green monkey cells, 1159 HeLa cells M2 replication Alu family sequence replication, 1476 alpha gene expression, 829 inhibition by M1, 1747 A protein binding to DNA, 2631 cell cycle progression, 829 MEL] transcript, 1238 Bal3l digestion, 604 Sperm-specific gene family mitochondrial components chromatin C. elegans, 529 glucose, 939 barriers to Bal3l digestion, 604 Spongilla lacustris transcription of genes that encode, chromatin structure, 1499 src gene product, 1179 939 DNA replication, 1499 Spore coat protein gene mRNA gap filling, 1286 cDNA, 2273 meiosis, 695 replication fork progression, 1286 D. discoideum, 2273 sporulation, 695 UV damage, 1286 Sporulation photoreactivation, 1864 early-region reacquisition by defective S. cerevisiae mRNA, 695 PHRI, 1864 DNA, 666 Sporulation-specific genes plasmid TLC-1 early-region transcription, 1900, 1915 S. cerevisiae, 142 recombinational instability, 195 enhancer activity src polyadenylate, transcriptionally en- promoter dependence, 1664 src coded, 101 homologous recombination Drosophila homolog, 982 proplasted cells, 771 T antigen genes. 1141 gene product detected in S. lacustris, PUT2, 2837 human embryonic kidney cell transfor- 1179 RADI, 2161 mation, 379 RSV src expression in avian macro- RAD2, 290 immune complex kinase assays, 232 phages, 1420 RAD52, 2735 induction by cell fusion, 1159 src initiation ras mRNA, 2298 insertion mutants, 1499 mutation of a termination codon, 1738 ras-related proteins, 23 large T-antigen src proteins with N-terminal deletions, R * dhfr as selective marker, 407 membrane interactions, 1542 1834 rearrangements near telomeres, 2509 large T-antigen-coding sequence is re- STE6 expression ribosomal protein 51, 1871 quired for transformation, 1661 negative regulation by a2 product, 2420 ribosomal protein S25 homology, 2535 large T antigen expressed in embryonal S. cerevisiae, 2420 ribosomes recognize non-AUG initia- carcinoma cell hybrids, 1657 Stress mRNA metabolism tion codons, 1191 large T-antigen point mutants chicken embryo cells, canavanine-treat- RNA2, 23% oncogenic transformation, 1125 ed, 1534 RNA3, 2396 viral DNA replication, 1125 Stress proteins, rat myoblast RNAII, 2396 late promoter, 2911 nuclear localization, 468 xvi SUBJECT INDEX MOL. CELL. BIOL.

phosphorylation, 468 Tetraphenylphosphonium cations glucose repression, 939 SUC2 derepression HeLa cells, 199 HeLa cells exposed to amino acid ana- S. cerevisiae, 2750 34K protein logs, 1063 upstream region, 2750 phosphorylation, 212 HIS4, 1246 SUC2-lacZ gene fusions, 2347 pp60srC_associated kinase activity, 212 human-specific rDNA transcription fac- supF of Escherichia coli turonigenicity in vole cells, 212 tor error-prone mutagenesis detected in 34K protein that is a pp6Ov-src substrate nucleolar dominance in mouse>hu- mammalian cells, 2227 cDNA clone complementary to se- man hybrid cells, 1306 Surface antigen quences, 1935 mouse dihydrofolate reductase gene, P. tetraurelia, 1583 34-Kilodalton substrate of pp60vsrc, 77 2921 Swiss 3T3 cells Thymic lymphomas mouse ribosomal spacer region, 822 p53 protein, 276 Mlvi-2 oncogenes proliferation, 276 mouse chromosome 15, 997 rat liver, 1493 Switch region deletion Thymidine kinase premature termination by human RNA Abelson virus-transformed B-lymphoid transfer to mouse Ltk- cells by PEG- polymerase II, 2031 cell line, 2905 mediated fusion with protoplasts promoter-specific binding factors, 221 Synemin prepared from bacteria containing rDNA, species-specific, 221 chicken lens, 1943 induced levels of TK, 1644 S. cerevisiae, 247, 1246 Syrian hamster cells Thymidine kinase expression S. cerevisiae genes that encode mito- DNA-dependent mutagenesis regulation through an internal segment chondrial components, 939 bromodeoxyuridine, 2449 of the cellular tk gene, 1777 SV40 early region, 1900, 1915 Thymidine kinase gene cluster SV40 major late promoter, 133 DNA methylation pattern, 611 termination in S. cerevisiae, 1515 Thymidine requirement X. laevis globin genes, 2109 D. discoideum mutants, 2784 Transcriptional inhibitors Tandem repeats Thymidylate synthase mRNPs, 415 human genes for U2 snRNA, 492 S. cerevisiae, 2858 Transcriptional regulation T-antigen tk gene human lymphocytes homologous recombination, 1141 AUG codon inserted in a retrovirus vec- mitogen-inducible gene, 2540 monkey cells tor, 743 tumor promoter, 2540 nuclear matrix, 1384 chicken, 1769, 1777 Transcription factor binding polyomavirus DNA replication in mu- chicken tk gene inserted in a retrovirus 5'-flanking regions of Drosophila rine embryonal carcinoma cells, vector, 743 tRNAHiS gene and tRNAHiS pseudo- 317 herpesvirus, 1777 gene, 2714 rat cells, 1141 homologous recombination between Transcript levels SV40, 1384, 1141 fragments inserted into a mouse cell DNA damage, 2356 SV40 mutants, 1125 genome, 852 S. cerevisiae, 2356 T17 cells HSV, 743 rransfected DNA DNA methylation, 2098 human, 2316 damage of the biologically active sub- Teleocidin internal segment, 1777 population, 387 phosphorylation of 42,000-dalton pro- regulation, 1777 expression in mouse Ltk- cells, 1641 teins on tyrosine in quiescent chick structure, 1769 human cells, 1951 cells, 30 tk enzyme expression, 1777 monkey cells, 1951 Telomeres 3T3 mouse cells mouse cells, 1951 rearrangements near, 2509 adipose conversion Transfection S. cerevisiae, 2509 human growth hormone, 228 avian retrovirus, 240 Teratocarcinoma-derived stem cells Toxic gene dimethyl sulfoxide, 1172 p94 gene expression, 2428 adenovirus, 1354 DNA ligation, 240 a-tubulin gene expression, 2428 Transactivation human cells Teratocarcinoma differentiation late herpes simplex virus promoter, 544 mutator phenotype toward parvovirus gene regulation, 2142 Transcription H-1, 324 Teratocarcinoma x Friend cell hybrids adenovirus early region IV, 791 mouse cells, 1260 retrovirus gene expression, 923 adenovirus ElI promoter, 1970 plasmids containing mouse rDNA, 576 Termination codon AdV-infected HeLa cells treated with polycations, 1172 Rous sarcoma virus, 1738 12-O-tetradecanoyl-phorbol-13-ac- rat cells src initiation, 1738 etate mutator phenotype toward parvovirus 12-O-Tetradecanoyl-phorbol-13-acetate brome mosaic virus genome, 2876 H-1, 324 epidermal growth factor receptor in hu- calcitonin/calcitonin gene-related pep- RSV DNA man fibroblasts, 1718 tide transcription unit molecular forms, 1260 human lymphocyte cDNA clone, 2540 expression and polyadenylation sites, Transferrin receptor mutation phosphorylation of 42,000-dalton pro- 2151 murine lymphoma cell lines, 1675 teins on tyrosine in quiescent chick citrate synthase Transformation cells, 30 derepression, 247 actin gene fusion, 2890 transcription in AdV-infected HeLa cloning of DNA corresponding to rare am, cloned, 117 cells, 563 transcripts of rat brain, 2187 cell surface expression of v-fms-coded Tetrahymena thermophila control region in protein-coding portion glycoproteins, 1999 Tetrahymena thermophila of adenovirus EIA genes, 1293 Chinese hamster cells, 368 cell surface interactions, 681 D. discoideum transposable element D. discoideum, 2890 ciliary membrane vesicles, 681 DIRS-1, 2332 enhancing sequence, 368 conjugation, 681 Drosophila homologs of the abl and src frequency, 368 starved cells that are unable to mount an cellular oncogenes, 982 gene expression, 368 effective heat shock response selec- Ela gene products, 1970 human cells, 1169 tively degrade their rRNA, 2170 globin, 17 human embryonic kidney cells VOL. 4, 1984 SUBJECT INDEX xvii

origin-defective SV40 DNA, 379 S-Tubercidinylhomocysteine mouse cells papovavirus replication, 379 mRNA metabolism in HeLa cells, 538 dihydrofolate reductase gene amplifi- N. crassa, 117, 2041 Tubulin cation, 1050 NIH 3T3 cells C. fasciculata, 779 methotrexate resistance, 1050 endogenous murine leukemia pro- a-Tubulin p53 cellular tumor antigen in mouse virus, 2247 gene expression cells, 1689 MCF-7 DNA, 2247 teratocarcinoma-derived stem cells plasmid pSV2, 1169 phenotype versus differentiated cells, 2428 SV40 DNA replication hormonal regulation, 712 P-Tubulin fork progression, 1286 SV40-transformed rat embryonic L. tropica, 1372 gap filling, 1286 preadipose cell lines, 712 f-Tubulin genes SV40 induction, 1159 polyoma middle-T antigen C. reinhardtii, 2686 transformation of human cells, 1169 N-terminal amino acid sequences, 817 ,3-Tubulin gene transcription protoplasted yeast cells stimulation by adenovirus 5 Ela, 2792 cell fusion, 771 Tubulin mRNA levels rat cell line EL2, 2925 lectin activation of lymphocytes, 1754 Vesicular stomatitis virus recombinant plasmids containing the 3-Tubulin mRNAs carboxyl terminus of glycoprotein G cloned am gene of N. crassa, 2041 neural cell specific, 1313 recombinant middle T antigen, 282 SV40 large T-antigen-coding sequence, rat brain development, 1313 nucleocapsid formation, 2231 1661 Tubulin genes v-fms-coded glycoproteins UV-irradiated pSV2 plasmids, 1169 consensus sequence, 1115 cell surface expression, 1999 Translation pseudopromoters, 1115 Vimentin synthesis adenovirus VA RNA&, 736 S. reinhardi, 1115 inhibition in SV40-infected monkey kid- HeLa cells exposed to amino acid ana- Tubulin proteins ney cells, 1880 logs, 1063 myxamoeba-flagellate transformation of Virus-like particle capsid proteins human histone gene regulation, 2723 P. polycephalum, 1706 M double-stranded killer plasmids, 2818 Translational control P. polycephalum myxamoeba-flagellate S. cerevisiae, 2818 chicken reticulocytes, 2437 transformation, 1706 Vole cells globin synthesis, 2437 Tumorigenicity assay phosphorylation of the 34K protein, 212 heat shock induction, 2437 human oncogenes pp60src-associated kinase activity, 212 HSP70 synthesis, 2437 mcf2, 1695 tumorigenicity, 212 Translational efficiency of cMyc mRNA in mc]3, 1695 VP5 promoter Burkitt lymphoma cells, 2235 N-ras, 1695 transactivation, 544 Transposable element DIRS-1 Type I collagen gene expression v-src location in a retrovirus vector, 2653 D. discoideum, 2332 tissue specificity is determined at tran- Transposable elements scriptional and post-transcriptional D. discoideum, 671 levels, 1843 Transposable element Ty Tyrosine phosphorylation sites gene activation polyomavirus middle-T antigen, 1334 Xenopus laevis carbon source, 61 Tyrosine protein kinase Xenopus laevis S. cerevisiae, 61 Rouse sarcoma virus calmodulin genes, 507 HIS4 transcription in S. cerevisiae, 1246 amino acid alterations in pp6(Yrc, 862 fibrinogen intrachromosomal movement by gene Tyrosine protein kinase activity mRNA for three subunits, 2543 conversion, 703 LSTRA cells, 2705 3-globin genes from the tadpole and S. cerevisiae, 329, 703 protein p56, 2705 adult injected into fertilized X. lae- Transposable element Tyl Tyrosyl kinase vis eggs, 567 iso-2-cytochrome c production in S. BHK cells that express v-src, 973 paired tandemly repeated sequences, cerevisiae CYC7-H2 mutants, 1393 254 tRNATYF gene expression RNA polymerase I promoter altered 5'-flanking sequences, 657 intercalating agents, 2851 S. cerevisiae, 657 U1 and U2 small nuclear ribonucleoprotein transcription of globin genes Tropomyosine gene splicing configurations oocytes, 2109 D. melanogaster, 2828 Mg2+ induces a transition, 1890 unfertilized eggs, 2109 muscle tropomyosin isoforms, 2828 Upstream activating sequence UASG Ul snRNAs encoded by a major family Tropomyosin polypeptides S. cerevisiae GALI-GALIO divergent of tandemly repeated genes, 2580 CEF, 1823 promoter region, 2467 Xenopus oocytes differential repression of transcription Ul small nuclear RNA pp6&v-src injection into, 1631 by RSV transformation, 1823 encoding by a major family of tandemly progesterone-induced meiotic matura- Trout cells repeated genes, 2580 tion, 1631 hsp70 cDNAs, 1785 X. laevis, 2580 ribosomal protein S6 phosphorylation, Trypsin U2 small nuclear RNA 1631 phosphorylation of 42,000-dalton pro- tandem repeats, 492 Xeroderma pigmentosum cells teins on tyrosine in quiescent chick Ustilago maydis virions enhanced reactivation and mutagenesis cells, 30 RNA polymerase, 188 of HSV, 2341 ts2O UV radiation X-linked gene of mice characterization. 1815 African green monkey cells murine leukemia virus DNA produc- correction of defect, 1815 SV40 induction by cell fusion, 1159 tion, 151 r,- US. 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19. FOR COMPLETION BY NONPROFIT ORGANIZATIONS AUTHORIZED TO MAIL AT SPECIAL RATES (Section 423.12 DMM only) The purpose, function, and nonprofit status of this organization and the exempt status for Federal income tax purposes (Check one) 111 1{2) ! HAS NOT CHANGED DURING j_ HAS CHANGED DURING (If changed, publisher meat submit explanation of PRECEDING 12 MONTHS U PRECEDING 12 MONTHS change with this statement.) 10. AVERAGE NO. COPIES EACH ACTUAL NO. COPIES OP 7 EXTENT AND NATURE OF CIRCULATION ISSUE DURING PRECEDING ISSUE PUBLISHED NEARESTSINGLETO (See instructions on reverse side) 12 MONTHS FILING DATE A. TOTAL NO. COPIES (Net Press Run) 5,268 5,204 B. PAID AND/OR REQUESTED CIRCULATION 1. Sales through dealers and carriers, street vendors and counter sales 2,897 3,270 r 2. Mail Subscription (Paid and/or requested) 749 891 C. TOTAL PAID AND/OR REQUESTED CIRCULATION (Sum of0JOBI and IOB2) 3,646 4,161 0. FREE DISTRIBUTION BY MAIL, CARRIER OR OTHER MEANS SAMPLES, COMPLIMENTARY, AND OTHER FREE COPIES 100 100 8E. TOTAL DISTRIBUTION (Sum ofCandDJ 3,746 4,261 F. COPIES NOT DISTRIBUTED 1. Office use, left over, unaccounted, spoiled after printing 1 ,522 943 2. Return from News Agents

G. TOTAL (Sum of E, Fl and 2-should equal net press run shown In A) 5,268 5,204

..TOTAL. I I._ IcSIGNATUAiwu1^ yn zn~~~~~~~~~uAsNiTITLE5?crEITORaLocvrcw vn, PUBISrv0o|wnrcn,BUSIN4CRDUOiFMr.IOMANAGERxCCe ORuOrWsNERRq-1 I certify that the statemnts made by I f/ Mnz^M^%nr, vn UVVFrwC me above are correct and complete -] PS Form 3526, July 1984 (See instruction on reverse) 1985 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN-SOCIETY FOR MICROBIOLOGY 1913 I Street, NW * Washington, DC 20006 * (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITrANCE IN U.S. FUNDS Eligibility ASM welcomes to full membership anyone who is interested in its objectives and has a minimum of a bachelor's de- gree orequivalent in microbiologyora related field. Initiation Memberships are initiated and renewed in January each year. Unless there are directions to the contrary, membership nominations received prior to November 1 are credited to the current year, and back issues of the selected publications for the current year are furnished, if available. Nominations received after November 1 will become effective the following January. NAM E FIRST INITIAL LAST ADDRESS CITY STATE/PROVINCE ZIP/POSTAL CODE COUNTRY PHONENUMBER( )_YEAROFBIRTH SEX_ HIGHEST DEGREE YEAR EARNED A MAJOR SUBJECT GRANTING INSTITUTION PRESENT POSITION CURRENT SCIENTIFIC AREA SIGNATURE DATE *NOMINATED BY SIGNATURE OF ASM MEMBER *If you are not associated with an ASM nominating member, you can still send in this full member application form and we will contact you. Dues Annual dues for 1985 are $57.00. with $8.00 allocated for ASM News and $8.00 for membership services. Apply the remaining $41.00 to subscriptions for the ASM journals at the special membership rates indicated below. Journals Please check: O Enclosed is my dues payment (in U.S. dollars only) ...... $57 O Please send me the following ASM journal(s) at Member Price(s): U.S. Non-U.S. Amount Antimicrobial Agents and Chemotherapy $31 $41 $. Applied and Environmental Microbiology 32 42 Molecular and Cellular Biology 37 45 Infection and Immunity 37 49 International Journal of Systematic Bacteriology 31 31 Journal of Bacteriology 37 49 Journal of Clinical Microbiology 31 41 Journal of Virology 37 49 Microbiological Reviews 16 26 Total Journal Fees $- Subtract your $41 Member Journals Credit $ 41 Subtotal (if less than zero, enter zero) $- Add your $57 Membership Dues $ +57 Total (Dues plus Journals). If total is less than $57.00, enter$57.00 $- PAYMENT IN U.S. DOLLARS MUST ACCOMPANY APPLICATION A membership card, voting registration form. Placement Committee form and the journal(s) of your choice will be sent within 90 days upon completion of processing. Dues for individual membership in ASM are tax deductible. Rates are for 1985 only. Non-U.S. applicants remit in U.S. dollars by check or draft payable to ASM through a U.S. bank located within the Continental U.S. Applicants from Canada may use check made out in U.S. dollars and drawn on a Canadian bank. U.S. and non-U.S. applicants may choose to pay with VISA or MasterCard. If that is your preference, please fill in the box below.

Z VISA # , MASTERCARD X EXPIRATION DATE TODAYS DATE SIGNATURE Minimum Charge $1 5.00 1985 APPLICATION FOR STUDENT MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1913 1 Street, NW * Washington, DC 20006 0 (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITTANCE IN U.S. FUNDS Eligibility Any matriculated student majoring in microbiology or a related field is eligible for election as a Student Member. Student Members have all the privileges of membership except the right to vote and hold office in the Society. Student Members receive the monthly ASM News and are entitled to subscribe to the Societys scientific journals at member rates. Initiation Memberships are initiated and renewed in January each year. Unless there are directions to the contrary, membership nominations received prior to November 1 are credited to the current year, and back issues of the selected publications for the current year are furnished, if available. Nominations received after November 1 will become effective the following January.

NAME - ADDRESS. CITY .RTATF/PRC)VINrFavI mlcr RTHIYEAR OF BI 71P/P()STAL conp COUNTRYU_1 rnTX PHONE NUMBER ( L YEAR OF B IRTH, SEX HIGHEST DEGREE SCHOOL MAJOR FIELD OF STUDY SIGNATURE OF NOMINEE DATE SIGNATURE OF CHAIRMAN OF MAJOR DEPARTMENT.

-NOMINATED--.- BY (1) SIGNATURE OF ASM MEMBER *If your departmental chairman is a member of the ASM, a nominating signature is not required. If you are not associated with an ASM nominating member, you can still send in this member application form and we will contact you. Be sure to include your dues.

Please check: EO Enclosed is my Membership Fee, includes ASM News (in U.S. dollars only) ...... $10 El Please send me the following ASM journal(s) at Member Price(s): Journals U.S. Non-U.S. Amount Antimicrobial Agents and Chemotherapy $31 $41 $- Applied and Environmental Microbiology 32 42 Molecular and Cellular Biology 37 45 Infection and Immunity 37 49 International Journal of Systematic Bacteriology 31 31 Journal of Bacteriology 37 49 Journal of Clinical Microbiology 31 41 Journal of Virology 37 49 Microbiological Reviews 16 26 Total Joumal Fees $- Add your $10 Membership Fee +10 Total $-

PAYMENT IN U.S. DOLLARS MUST ACCOMPANY APPLICATION Rates are for 1985 only A membership card and the journal(s) of your choice will be sent within 90 days upon completion of processing. Dues for individual membership in ASM are tax deductible. Non-U.S. applicants remit in U.S. dollars by check or draft payable to ASM through a U.S. bank located within the Continental U.S. Applicants from Canada may use check made out in U.S. dollars and drawn on a Canadian bank. U.S. and non-U.S. applicants may choose to pay with VISA or MasterCard. If that is your preference, please fill in the box below.

a VISA # 0 MASTERCARD * EXPIRATION DATE TODAYS DATE SIGNATURE Minimum Charge $1 5.00