MOLECULAR AND CELLULAR BIOLOGY VOLUME 3 * NUMBER 12 * DECEMBER 1983 Aaron J. Shatkin, Editor in Chief (1985) Roche Institute of Molecular Biology Nutley, N.J. Harvey F. Lodish, Editor (1986) Louis Siminovitch, Editor (1985) Massachusetts Institute of Technology Hospital for Sick Children Cambridge, Mass. Toronto, Canada David J. L. Luck, Editor (1987) Paul S. Sypherd, Editor (1985) Rockefeller University University of California New York, N.Y. Irvine, Calif.

EDITORIAL BOARD Renato Baserga (1985) Ira Herskowitz (1984) Daniel B. Rifkin (1985) Alan Bernstein (1984) Larry Kedes (1985) Robert G. Roeder (1985) J. Michael Bishop (1984) Marilyn Kozak (1985) James E. Rothman (1984) Joan Brugge (1985) Elias Lazarides (1985) Phillip A. Sharp (1985) Breck Byers (1985) John B. Little (1985) Fred Sherman (1985) John A. Carbon (1984) William F. Loomis, Jr. (1985) Pamela Stanley (1985) Lawrence A. Chasin (1985) Paul T. Magee (1985) Joan A. Steitz (1985) Nam-Hai Chua (1985) Robert L. Metzenberg (1985) James L. Van Etten (1985) Terrance G. Cooper (1984) Robert K. Mortimer (1985) Jonathan R. Warner (1984) James E. Darneil, Jr. (1985) Harvey L. Ozer (1985) Robert A. Weinberg (1984) Gary Felsenfeld (1985) Mary Lou Pardue (1985) I. Bernard Weinstein (1985) Norton B. Gilula (1985) Mark Pearson (1985) Harold Weintraub (1985) James E. Haber (1984) Jeremy Pickett-Heaps (1985) Reed B. Wickner (1985) Benjamin Hall (1985) Robert E. Pollack (1985) Leslie Wilson (1985) Ari Helenius (1984) Keith R. Porter (1985) Edward Ziff (1985) Susan A. Henry (1985) John R. Pringle (1985)

Helen R. Whiteley, Chairman, Publications Board Walter G. Peter Ill, Director, Publications Linda M. Illig, Managing Editor, Journals Eleanor S. Tupper, Production Editor

Molecular and Cellular Biology (ISSN 0270-7306) is devoted to the advancement and dissemination of fundamental knowledge concerning the molecular biology of eucaryotic cells, of both microbial and higher organisms. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Office. The journal is published monthly, one volume per year. The nonmember subscription price is $84 per year; single copies are $9. The member subscription price is $22 (foreign $26 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publication Office, 1913 1 St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues "missing from files' will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Molecular and Cellular Biology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the United States of America. Copyright © 1983, American Society for Microbiology. i*: A lt(1' All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Antequera, Francisco, 2287 Harris, John F., 2271, 2280 Parada, Luis F., 2298 Held, William A., 2232 Hodgson, Clague P., 2221 Barclay, Stephen L., 2117 Reich, Nancy C., 2143 Benham, F. J., 2259 Richter, J. D., 2131 Innis, Jeffrey W., 2203 Robertson, M., 2211 Bernstein, Alan, 2180, 2191 Rogers, J., 2166 Bostock, C., 2211 Rudnicki, Michael A., 2271 Jones, N. C., 2131 Christie, S., 2211 Jones-Villeneuve, Elizabeth Santos, Tomas, 2287 M. V., 2271 Sanwal, B. D., 2166 Joyner, Alexandra L., 2180, 2191 Scott, Walter A., 2203 Dahlberg, J. E., 2211 Shatkin, Aaron J., 2172 Simonsen, Christian C., 2250 Knopf, John L., 2232 Smith, Gale E., 2156 Edwards, Mary K. S., 2280 Smith, James H., 2151 Elder, Paula K., 2221 Smith, L. D., 2131 Eliceiri, George L., 2151 Levine, Arnold J., 2143 Summers, Max D., 2156 Ernst, Heinrich, 2172 Levinson, Arthur D., 2250 Lund, E., 2211 Tamame, Mercedes, 2287 Temin, Howard M., 2241 Filipowicz, Witold, 2172 Foster, Douglas N., 2221 McBurney, Michael W., 2271, Fraser, M. J., 2156 2280 Villanueva, Julio R., 2287 Melier, Erna, 2117 Mitchen, J. L., 2211 Gallagher, John F., 2232 Watanabe, Shinichi, 2241 Getz, Michael J., 2221 Weeks, D. L., 2131 Gilfix, B., 2166 Ono, Tetsuya, 2221 Weinberg, Robert A., 2298 Goodfellow, P. N., 2259 Oren, Moshe, 2143 Wiles, M. V., 2259 ACKNOWLEDGMENT The following have served as invited special reviewers for the journal during 1983, and their help is greatly appreciated. George Acs Herbert Ennis George Khoury Bruce Adams Ronald Evans David Knipe Eileen Adamson Phillip Feigelson Barbara Knowles Irene Andrulis James Feramisco Monty Krieger Herbert N. Arst, Jr. John Fessler F. Lacroute Susan Astrin David Finkelstein C. J. Lai Corrado Baglioni Jane Flint Alan Lambowitz Andrew Ball Wayne Flintoff Gayle Lamppa David Baltimore William Frazier Ronald Laskey Amiya Banerjee Karl Freeman Robert Lawther Heinz Baumann Robert Friedman Paul Lefebvre Robert Benbow Alice Fulton Michael Leibowitz Thomas Benjamin Joseph Gall Peter Lengyel Marian Beremand Alan Garen Arnold Levine Susan Berget J. I. Garrels Susan Lindquist Merton Bernfield Patricia Gearhart Vic Ling Kenneth Berns Peter Geiduschek Stuart Linn Elizabeth Blackburn Raymond Gesteland Elwood Linney Peter Blumberg Eli Gilboa Peter Linsley Keith Bostian Harold Ginsburg David Livingstone Michael Botchan Yakov Gluzman Paul Lizardi David Botstein Steve Goff Peter Lomedico Ted Bradley Allan Goldberg Vivian Mackay M. Breitenbach E. G. Gollub Robert Malone Martin Breitman Martin Gorovsky James Manley J. R. Broach Michael Gottesman Thomas Manney Thomas Broker Frank Graham Kenneth Marcu Jeremy Bruenn Steve Grant Steve Martin Joseph Bryan Mark Groudine George Marzluf Manuel Buchwald Leonard Guarente Michael Matthews Howard Bussey Rad Gupta Michael McBurney Ron Butow Dean Hamer Roderick McInnes Judith Campbell Hidesaburo Hanafusa Steve McKnight Mario Capecchi Roger Hand Janet Mertz Mary Case Leland Hartwell Mathew Meselson Francis Castellino Vincent Hascall, Jr. Mark Meuth Sewell Champe William Haywood Malcolm Moore Clarence Chan Joyce Heckman Steve Mount Lan Bo Chen T. L. Helser Richard Mulligan Rex Chisholm Ellen Henderson Paul Neiman Albert Chung David Henner Yale Nemerson Stanley Cohen James Hicks Walter Neupert Christopher Coleclough David Hirsch Joseph Nevins Jonathan Cooper M. J. Holland Carol Newlon Nicholas Cowan Anita Hopper Maynard Olson Brian Cox J. E. Hopper Yasuji Oshima William Crane Stephen Howell Brad Ozanne George Cross Peter Howley Richard Palmiter Lloyd Culp Ann Hubbard Thoru Pederson Samuel Dales Joel Huberman Hugh Pelham Kathleen Danna Tony Hunter Sheldon Penman Ronald Davis Marcello Jacobs-Lorena D. Perlman Rowland Davis Alan Jacobson P. S. Perlman Carol Dieckmann Warren Jelinek Sidney Pestka Robert Dottin Edward Johnson Thomas Petes Gideon Dreyfuss Grace Ju Magnus Pfahl Thomas Easton Robert Kamen James Pipas Argiris Efstratiadis Kathleen Karrer David Prescott Ellis Englesberg Randy Kaufman Murray Rabinowitz Uttam Rajbhandary Mark Shotwell Robert Tjian Peter Ray Mohammed Siddiqui Paul Torrence Steve Reed Carolyn Silflow La-Chee Tsui Richard Rifkind Samuel Silverstein George vandeWoude Jasper Rine Richard Singer Harold Varmus G. S. Roeder Anna Skalka Alexander Varshavsky Bernard Roizman Arthur Skoultchi Inder Verma Michael Rosbash Martin Snider Jan Vilcek Jack Rose Davor Solter Robert Wagner Naomi Rosenberg Patricia Spear Eugenia Wang M. Rosentraus George Stark David Ward Jeffrey Ross Nat Stemnberg Donald Weeks Joan Ruderman Bernard Strauss Martin Weigert Frank Ruddle Sidney Strickland Eric Weinberg H. Ruis Kiranur Subramanian Alan Weiner David Sabatini Ako Sugino Irving Weissman Robert Schimke Jack Szostak Sherman Weissman Milton Schlesinger Igor Tamm Curtis Wilkerson David Schlessinger John Taylor Fred Winston Bartholomew Sefton Peter Tegtmeyer Dyann Wirth Pravinkumar Sehgal Larry Thompson Ronald Worton Ganes Sen Jeremy Thorner Keith Yamamoto Thomas Shenk W. Timberlake Men-Chao Yao Michael Sherman D. J. Tipper Michael Young INDEX TO DATE OF ISSUE

Month Date of Issue Pages January 6 January 1983 1-147 February 4 February 1983 149-296 March 3 March 1983 297-494 April 30 March 1983 495-756 May 3 May 1983 757-965 June 2 June 1983 967-1162 July 28 June 1983 1163-1332 August 5 August 1983 1333-1543 September 2 September 1983 1545-1685 October 10 October 1983 1687-1887 November 2 November 1983 1889-2115 December 2 December 1983 2117-2301

STATEMENT OF OWNERSHIP MANAGEMENT AND CIRCULATION IA TITLE OF PUBLICATION IS. PUUCAlTON NO. 2. OATE OF FILING Molecular and Cellular Biology I i i i i i 30 September 1983 3. FREQUENCY OF ISUE 3A. NO.OF ISSUNSP LISHEO 25. ANNUAL SUSCRWPTIOFI LI.Y PtIClE Monthly 12 $22 abr, $84 nonabr 4. COMPLETE MAILING ADORES Of INOt OFfCEOF PtLICATION (et, CSy. aMety,Syawe.eZScZok f'oatPAneJ 1913 I Street, N.W., Washington, D.C. 20006 5 COMPLETE MAILING ADORES Of THE HEADOUANTEtS OF GENERAL WEINE#D OFFICES OF THE PUBLISHER (NeotePte, 1913 I Street, N.W., Washington, D.C. 20006 6. FULL NAMES ANO COMPLETE MAILING ADOREO OF PUBLISHER. EOITOR. ANDMANAGING EDITOR (NIi mUSrI TNorDb.E.Mk PUNLISHER (N... ACet*_ .p AeEA Amlerican Society for Microbiology. 1913 I Street, N.W., Washington, D.C. 20006 EDITOR N_..WtCap_ I's Adew Director of Publications W lter G. Peter III 1913 I Street, 11-W. shingtoD,D. C 20006 MANAGING EDITOR It_.. _ C--k_tt AO_ AIIIIIsr Walter G. Peter III, amE Os above 7. 01g@^ _ {t_ _ k _ ofs__ktAt$

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F. (See instruction on reverse MY ISO 352 1#2 AUTHOR INDEX VOLUME 3

Abelson, Leslie, 903 Brandriss, Marjorie C., 1846 Courtneidge, Sara A., 1077 Abulafia, Rivka, 684 Brawerman, George, 1197 Covey, Lori, 1958 Adair, Gerald M., 1967 Breter, Hans-Joachim, 881 Cowan, N. J., 854, 1738 Adamson, Eileen D., 1062 Brison, Olivier, 2076 Cox, David, 20 Alitalo, Kari, 340 Brown, Anne, 1371 Crawford, Brian D., 931 Al-Ubaidi, Muayyed, 819 Brown, Peter C., 1097 Creasey, Abla A., 780 Anderson, Nancy, 562 Brugge, Joan, 9 Crerar, Michael M., 946 Anderson, W. French, 1246 Brugge, Joan S., 1157 Crouse, Gray F., 257 Andrulis, Irene L., 391 Bruno, John, 1866 Crowley, Craig W., 44 Antequera, Francisco, 2287 Bruns, Peter J., 1857 Crowley, Thomas E., 623 Ardeshir, Feroza, 2076, 2089 Buck, Gregory, 410 Curran, Tom, 914 Ares, Manuel, Jr., 1537 Buckholz, Richard G., 1889 Arfin, Stuart M., 1937 Bussey, H., 1362 Ascione, R., 305 Butow, Ronald A., 1615 Asselin, Claude, 1451 Byrne, Janet C., 2110 Dahlberg, J. E., 2211 Avvedimento, Vittorio E., 2099 Dallman, Thomas, 1537 Axelrod, David E., 1163 Dana, Sharon, 892 Azizkhan, J. C., 1266, 1274 Cabib, Enrico, 922 Danielsen, Mark, 1310 Caliguiri, Lawrence A., 1656 Danna, Kathleen J., 290, 484 Campbell, Judith L., 1730 Danell, James E., Jr., 1212, 1552 Babich, Alexander, 1212 Caplan, Shari, 1975 Darrow, Diane, 9 Baglioni, Corrado, 64 Carlson, Marian, 351, 439 David, Emina, 946 Baker, Ellen J., 974 Carroll, Dana, 720 Delihas, Neva C., 172 Bakhanashvili, Mary, 1759 Casadaban, Malcolm J., 580 DeLisle, Alice J., 1920 Baltimore, David, 773 Caskey, C. Thomas, 1086 Deng, Jau-Shyong, 1235 Baltz, Dominique, 399, 410 Castiglia, C. L., 662 Denis, Clyde L., 360 Baltz, Th6o, 399, 410 Cathala, Guy, 1353 Dennis, James W., 523 Barclay, Stephen L., 2117 Celeste, Anthony, 1930 Deutscher, Murray P., 1711 Barrett, J. Carl, 931 Cereghini, Silvia, 1197 Di Fiore, Pier Paolo, 2099 Baserga, Renato, 214 Chang, Chungming, 1133 Dick, Ronald L., 70 Bastin, Marcel, 1451 Chang, Stephen, 429, 761 Didsbury, John R., 1283 Beck, Anton K., 1609 Chapman, Alger B., 1421 Dion, L. David, 1527 Bedows, Elliott, 712 Cheetham, Brina F., 480 Dixon, Kathleen, 1403 Benham, F. J., 2259 Chen, Ling-Chun, 1077 Dobner, P. R., 854, 1738 Ben-Ze'Ev, Avri, 684 Chen, Ting-Yao, 1133 Doehmer, Johannes, 1032 Ben-Ze'ev, Avri, 182 Chisholm, Rex L., 1511 Dolecki, Gregory J., 1021 Berard, Diana S., 2045 Chou, Chen-Kung, 1133 Donaghue, Terrence P., 523 Berg, Leslie, 1108 Chou, Janice Yang, 1013 Drobetsky, Elliot, 1882 Berg, Patricia E., 1246 Christie, S., 2211 Drum, Cynthia C., 1718 Berg, Paul, 280, 991, 1040 Cirullo, Ronald E., 892 Dudley, L., 854 Berget, Susan M., 819 Clark, Robin, 220 Duff, Catherine, 391 Bernstein, Alan, 2180, 2191 Clayton, Christine E., 2089 Dutcher, Susan K., 1255 Bhat, Ramesh A., 1996 Clayton, David F., 1552 Bishop, J. Michael, 340, 1077 Cleveland, D. W., 1738 Bjerknes, Clara A., 172 Cline, Martin J., 1062 Edgell, Marshall H., 1163 Blanton, Harriet M., 1898 Coffin, John M., 1746 Edwards, Mary K. S., 2280 Blau, Helen, 787, 1783, 1985 Coffino, Philip, 250 Eisen, Harvey, 399, 410 Bodnar, John W., 1567 Colburn, Nancy H., 1182, 1527 Eisen, Herman N., 1343 Boettiger, D., 113 Cole, Charles N., 267, 643 Eissenberg, Joel C., 1724 Boettiger, David, 1518 Cole, Kenneth W., 1609 Elder, Paula K., 2221 Bond, Julian F., 1333 Collett, Marc S., 1589 Elgin, Sarah C. R., 1724 Bond, Martha W., 623 Colletta, Giulia, 2099 Eliceiri, George L., 2151 Bostian, K. A., 1362 Colfins, Mark L., 1792 Engel, Joanne, 787 Bostian, Keith A., 570, 839 Conrad, Michael N., 1000, 1665 Ennis, Herbert L., 1943 Bostock, C., 2211 Coombs, David H., 1567 Eppstein, Deborah A., 780 Botchan, Michael, 325, 1108 Cooper, Jonathan A., 56 Epstein, Lloyd M., 466 Botstein, David, 351, 439 Cooper, Terrance G., 1889 Ernst, Heinrich, 2172 Boutelet, Francoise, 415 Corrick, Catherine M., 1430 Evans-Blackler, Susan, 391 Bowers, Blair, 922 Costello, Maureen A., 1421 Bowman, Lewis H., 1488, 1501 Cotton, Patricia C., 1157 Bradley, W. E. C., 1172, 1703 Courchesne, William E., 672 Falk, Heinz, 693 Brake, Anthony J., 1440 Courtneidge, Sara, 340 Farmer, Stephen R., 182, 1333

i ii AUTHOR INDEX MOL. CELL. BIOL. Farrelly, Frances, 1615 Hager, Gordon L., 2045 Karrer, Kathleen M., 1909 Feldman, Lawrence T., 829, 1212 Hager, Lisa J., 1898 Kassir, Yona, 871 Fenwick, Raymond G., Jr., 1086 Haimovich, Joseph, 1317 Kaufman, Randal J., 32, 699, 1598 Ferguson, Jill, 881 Hall, J. L., 854 Kaur, Kiran, 1187 Ferrentino, Maria, 2099 Hallberg, Elizabeth M., 503 Kedes, Larry, 787, 1783, 1985 Ferris, Patrick J., 635 Hallberg, Richard L., 503 Kellems, Rodney E., 819 Fessl, Friederike, 1545 Halvorson, Harlyn O., 839 Keller, Elizabeth B., 448 Filipowicz, Witold, 2172 Hamlin, J. L., 1266, 1274 Kelly, Linda J., 1943 Finkelstein, David B., 1625 Hardies, Stephen C., 1163 Kelly, Rosemarie, 1943, 1949 Firestone, Gary L., 149, 551 Harris, John F., 2271, 2280 Kerbel, Robert S., 523 Fishmann, P. H., 91 Harris, Morgan, 1937 Khan, Zevi, 780 Flint, S. J., 662 Hartwell, Leland H., 1255 Khandjian, Edouard W., 1 Fogel, Seymour, 1353 Hassell, John A., 1670, 1680 Kim, Chung H., 457 Foran, David R., 1824 Hatfield, G. Wesley, 1687 Kim, Kwan Hee, 495 Forney, James D., 466 Hayward, Gary S., 1389 King, Julie A., 1430 Foster, Douglas N., 2221 Hebert, M. Brenda, 1501 Kirschimeier, Paul T., 1123 Frackelton, A. Raymond, Jr., 1343 Heintz, Nathaniel, 539 Klar, Amar J. S., 803 Frahm, Michelle, 190, 198 Held, William A., 2232 Klein, William H., 466 Fraser, M. J., 2156 Hendrickson, Sidney L., 1478, Knipe, David M., 315 Fregien, Nevis, 1021 1792 Knopf, John L., 2232 Fromm, Michael, 991 Herskowitz, Ira, 871 Kramer, Richard A., 562, 570 Frontali, L., 371 Hibner, Urszula, 399, 410 Kriegler, Michael, 325 Fuchs, E. V., 1738 Hicks, James B., 803, 871 Krowczynska, Anna, 1197 Fuchs, Elaine V., 495 Hilger, Francois, 415 Kuo, Chia-Lam, 1730 Fukuhara, H., 371 Hodgson, Clague P., 2221 Kustu, Sydney, 439 Fulford, Wilder D., 1540 Hofschneider, Peter H., 1032 Furmanski, Philip, 982 Holland, Louis E., 2028 Fusco, Alfredo, 2099 Holloman, William K., 605 Fuscoe, James C., 1086 Holtzer, H., 113 Holtzer, Howard, 1518 LaGarde, Alain E., 523 Hook, Amy G., 819 Landfear, Scott M., 1070 Gaertner, Frank H., 1609 Horwich, Arthur L., 511 Lansman, Robert A., 1694 Galanti, Norbel, 214 Howell, Stephen H., 1537 Larimer, Frank W., 1609 Gallagher, John F., 2232 Howley, Peter M., 233, 2110 Latt, Samuel A., 32, 699 Ganesan, A. T., 956 Hu, Cheng-Po, 1133 Laub, Orgad, 1766, 1774 Garber, Ellen A., 1656 Huang, Alice S., 1580 Law, Ming-Fan, 2110 Gattoni-Celli, Sebastiano, 1123 Huang, Ru Chih C., 1371 Lazarides, Elias, 1412 Gelinas, Celine, 1451 Hudspeth, Michael E. S., 1615 Leather, Richard, 946 Getz, Michael J., 2221 Huei-Yuh Guo, Wade, 1580 Ledbetter, David H., 1086 Giese, Gunter, 693 Humphreys, Tom, 1021 Lee, Frank, 1421 Gilfix, B., 2166 Hunter, Tony, 56 Lee, Tian-shing, 1133 Gilmartin, Gregory M., 1834 Hutchison, Clyde A., III, 1163 Lemire, Joan M., 839 Gindhart, Thomas D., 1182 Hynes, Michael J., 1430 Lerman, Michael I., 960 Giroud, Christine, 399, 410 Levine, Arnold J., 2143 Giulotto, Elena, 2076, 2089 Levine, Myron, 2028 Glorioso, Joseph C., 2028 Ikuta, Satoshi, 750 Levinson, Arthur D., 44, 2250 Gluzman, Yakov, 1958 Infante, Anthony A., 974 Levy, Barcey T., 102, 1718 Godman, Gabriel C., 132 Innis, Jeffrey W., 2203 Lewis, John A., 1815 Goldberg, Allan R., 1656 Ivarie, Robert D., 1460 Lewis, S. A., 854 Goldberg, Gregory, 1488 Lewis, William H., 1053 Goldberg, Gregory I., 1501 Jeang, Kuan-Teh, 1389 Leys, Eugene J., 819 Goldin, Alan L., 2028 Jhappan, C., 305 Liao, Warren S. L., 2076 Goldman, William E., 1488, 1501 Johansen, Hanne, 1246 Lifshitz, Ruth, 903 Gonatas, J., 91 Johnson, Lee F., 1792, 1920 Lin, Stanley L., 1656 Gonatas, Nicholas K., 91 Johnson, Patricia J., 1824 Lin, Yuehming, 1133 Goodfellow, P. N., 2259 Jolicoeur, Paul, 1675 Liu, Chung-Cheng, 44 Graves, Reed A., 1920 Jonak, Gerald J., 214 Liu, Tse-Jia, 1133 Greene, D., 1362 Jones, Carol J., 1567 Lo, Cecilia W., 1803 Greenspan, Jeffrey, 1967 Jones, N. C., 1222, 2131 Locatell, Kathryn L., 70 Greisen, K. S., 1266 Jones-Villeneuve, Elizabeth Lodish, Harvey F., 1511 Grossman, Lawrence I., 1615 M. V., 2271 Longacre, Shirley, 399, 410 Grund, Stephen H., 1634 Joyner, Alexandra L., 2180, 2191 Longley, Clifford, 982 Gunning, Peter, 787, 1783, 1985 Julius, David J., 1440 Loomis, William F., 863 Guntaka, Ramareddy V., 811, Lowe, David G., 1540 1975 Lucas, Joseph J., 1866 Gupta, Radhey S., 1468 Kao, Hung-Teh, 2058 Lund, E., 2211 Gurney, Elizabeth G., 290 Karin, Michael, 1353 Lusky, Monika, 1108 VOL. 3, 1983 AUTHOR INDEX iii

Madjar, Jean-Jacques, 190 Neumann, D., 1648 Quinlan, Margaret P., 315 Magasanik, Boris, 672 Nevins, Joseph R., 829, 1212, 2058 Malamy, Michael, 1746 Newlon, Carol S., 1000, 1665 Mandel, Morton, 1021 Nielsen-Smith, Kathryn, 198 Maness, Patricia F., 102, 1718 Nilsen, Timothy W., 64 Raibaud, Anna, 399, 410 Mangiarotti, Giorgio, 1511 Niman, Henry L., 863 Rall, Leslie B., 1766, 1774 Manley, James L., 811 Nomura, Shintaro, 757 Ralston, Robert, 340 Manos, M. Michele, 490 Nover, L., 1648 Rao, K. M. K., 712 Marks, Paul A., 229 Nyiresy, Paul, 903 Rassart, Eric, 1675 Maroney, Patricia A., 64 Reed, Steven I., 881 Maroteaux, Luc, 233 Reich, Nancy C., 2143 Marsh, Y. Vivienne, 780 Reuben, Roberta C., 229 Martin, Robert G., 421 Revel, Michel, 233 Martindale, Duane W., 1857 Obata, Yuichi, 750 Reyes, Antonio A., 750 Martinez, Ricardo, 380 Oberman, Froma, 1759 Rheinwald, James G., 495 Martinez-Arias, Alfonso E., 580 O'Farrell, Patrick H., 1460 Richard-Foy, Helene, 2045 Marzluff, William F., 1920 Oishi, K. K., 587 Richter, J. D., 2131 Mayrand, Sandra, 161 Oishi, Michio, 757 Rifkind, Richard A., 229 Mays-Hoopes, Laura L., 1371 Okayama, Hiroto, 280, 787 Ringold, Gordon M., 1421 McBurney, Michael W., 2271, O-Lee, Tsia-Wei, 1133 Robberson, Barbara L., 819 2280 Olsen, Anne S., 2017 Roberts, Rowena L., 922 McEwan, Robert N., 257 Ono, Tetsuya, 2221 Robertson, M., 2211 McGeady, M. L., 305 Oren, Moshe, 2143 Roeder, Robert G., 539 McGill, Shirley, 190, 198 O'Rourke, Edward J., 1580 Rogers, J., 2166 McKercher, Scott, 214 Orr-Weaver, Terry L., 747 Rohrschneider, Larry, 731 McMahon-Pratt, Diane, 1070 Ostrowski, Michael C., 2045 Rohrschneider, Larry R., 475 McOsker, Paul, 448 Rosenberg, Martin, 1246, 1687 McReynolds, Larry A., 490 Rosok, Mae J., 475, 731 Mehta, Kamal Deep, 1468 Pacifici, Maurizio, 1518 Ross, Alonzo H., 1343 Meller, Erna, 2117 Palleschi, C., 371 Roth, Gunther E., 1898 Menko, A. S., 113 Panet, Amos, 1759 Roufa, Donald J., 190, 198 Merigan, Thomas C., 780 Parada, Luis F., 2298 Rowe, Lucy B., 241 Mermer, Brion, 1746 Park, Colin, 982 Rubnitz, Jeffrey, 2066 Mertz, Janet E., 126 Parsons, J. Thomas, 1834 Ruddle, Frank H., 511 Metz, Beth, 1996 Patil, Shiva R., 1634 Rudikoff, Stuart, 903 Meuth, Mark, 1882 Pauw, Peter G., 1634 Rudman, Bertina M., 466 Meyerowitz, Elliot M., 623 Pearson, George D., 1567 Rudnicki, Michael A., 2271 Michels, Corinne, 7% Pearson, Mark L., 257, 946 Ruis, Helmut, 1545 Milbrandt, J. D., 1266, 1274 Pease, Larry R., 750 Rusche, James R., 605 Miller, Timothy J., 126 Peden, Keith, 220 Russell, David W., 20 Mitchen, J. L., 2211 Peden, Keith W. C., 203, 214 Rutter, William J., 1766, 1774 Mitrani-Rosenbaum, Stella, 233 Pederson, Thoru, 161 Rytka, Joanna, 1545 Mitsialis, S. Alex, 811, 1975 P'Eng, Fang-Ku, 1133 Moehring, Joan M., 1283 Penman, Sheldon, 182 Moehring, Thomas J., 1283 Perkins, Archibald S., 1123 Saffer, Jeffrey D., 960 Mommol, T., 91 Perry, Robert P., 1317 Salzberg, Samuel, 1759 Moore, Gordon P., 1824 Peterson, David O., 1310 Sanders, Marilyn M., 2017 Moran, Larry A., 1540 Peterson, Thomas A., 881 Sandri-Goldin, Rozanne M., 2028 Morse, C. C., 1609 Petes, Thomas D., 1204 Sankar-Mistry, Perin, 1675 Mortimer, Robert K., 1886 Phillips, Stephen L., 1949 Santangelo, George M., 267, 643 Mory, Yves, 233 Pinto, Antonio, 2099 Santiago, Carlos L., 1792 Muller, Dagmar, 1062 Pipas, James M., 203, 214, 220 Santos, Tomas, 2287 Muller, Rolf, 1062 Pizer, Lewis I., 1235 Sanwal, B. D., 2166 Muller, William J., 1670 Plagemann, Peter G. W., 82 Satz, M. Leonardo, 2006 Munroe, Scot D., 490 Plancke, Yves D., 1412 Saville, D., 1362 Murray, Ben A., 863 Pomerantz, Betsy J., 1680 Schacter, Beth S., 1460 Murray, Mark J., 32 Ponte, Phyllis, 787, 1783, 1985 Schaefer-Ridder, Maria, 1032 Murti, K. G., 1562 Popovic, Zvezdana, 1246 Scharf, K.-D., 1648 Preer, John R., Jr., 466 Schellekens, Huub, 1656 Preer, Louise B., 466 Scheller, Arno, 1958 Nakamura, Kenji D., 380 Prescott, David M., 1562 Scher, Charles D., 70, 1478 Nathans, Daniel, 203, 220 Prives, Carol, 1958 Schimke, Robert T., 1097 Nathenson, Stanley G., 750 Profous-Juchelka, Helen R., 229 Schlessinger, David, 1488, 1501 Naujokas, Monica A., 1670, 1680 Prudente, Doris, 803 Schuler, Mary A., 448 Needleman, Richard B., 796 Przybytkowska, Ewa, 490 Schulze, Dan H., 750 Nelson, Kathleen J., 1317 Purchio, A. F., 1589 Schumperli, Daniel, 1246 Nelson, W. James, 1146 Puziss, Marla B., 82 Schwarz, Richard I., 241 iv AUTHOR INDEX MOL. CELL. BIOL. Sclair, Morton, 1930 Talmadge, Catherine B., 1182 Watanabe, Shinichi, 2241 Scott, Richard W., 1295 Tamame, Mercedes, 2287 Watts, Teresa, 1187 Scott, Walter A., 2203 Tamm, Igor, 1656 Wawra, Edgar, 297 Sefton, Bartholomew M., 56 Tan, Eng M., 1235 Weber, Michael J., 380 Seif, Isabelle, 1138 Tannenbaum, Janet, 132 Weeks, D. L., 1222, 2131 Seif, Roland, 1138 Taussig, Ronald, 439 Weiher, Hans, 1108 Shade, Rosemary O., 1694 Taylor, Milton W., 1703 Weinberg, Robert A., 32, 2298 Shah, Harshad O., 1634 Temin, Howard M., 2241 Weinberger, Cary, 1212 Sharp, Janice A., 1687 Tewari, K. K., 587 Weinstein, I. Bernard, 1123 Sharp, Phillip A., 699, 1598 Thayer, Ronald E., 967 Welch, Juliet W., 1353 Shatkin, Aaron J., 2172 Thill, Gregory P., 562, 570 Wells, Susan K., 1589 Sheflin, Lowell, 1930 Thimmappaya, Bayar, 1996 Welsh, Michael J., 712 Shimizu, Kenji, 1815 Thorner, Jeremy, 1440 Wesolowski, M., 371 Shobu, Naoyuki, 757 Tilghman, Shirley M., 1295 Whipple, Andrew P., 70 Siciliano, Jeanette, 1967 Tipper, D. J., 1362 Whitaker-Dowling, Patricia A., Siciliano, Michael J., 1967 Tjian, Robert, 220 1533 Siddiqui, Aleem, 143 Tlsty, Thea D., 1097 White, James H., 1403 Siminovitch, Louis, 391 Toyama, Y., 113 White, Jeffrey D., 1866 Simon, Anne E., 1703 Traczyk, Aleksandra, 1545 White, R. Tyler, 1381 Simonsen, Christian C., 2250 Traub, Peter, 1146 Whitlock, Cheryl A., 596 Singer, Dinah S., 903, 2006 Tremblay, Joanne M., 1062 Wickner, Reed B., 415, 654 Singer, Maxine F., 967 Triemer, Dona F., 2017 Widmayer, Dorothea J., 466 Sive, Hazel L., 539 Truitt, Christine L., 635 Widnell, Christopher C., 1533 Skoneczny, Marek, 1545 Ts'o, Paul 0. P., 931 Wilcox, David K., 1533 Slamon, Dennis J., 1062 Tsuchida, Nobuo, 2099 Wiles, M. V., 2259 Slater, Martin L., 922 Turler, Hans, 1 Williamson, Valerie M., 20 Slott, Edwin F., Jr., 1694 Turner, Katherine J., 570 Wintersberger, Erhard, 297 Smith, Gale E., 2156 Wirth, Dyann F., 1070 Smith, James H., 2151 Witte, Owen N., 596 Smith, L. D., 2131 Ucker, David S., 551 Wohlhueter, Robert M., 82 Smith, Michael, 20 Uliman, Buddy, 1187 Wolford, Ronald G., 2045 Smolik-Utlaut, Sarah, 1204 Woodworth-Gutal, Mary, 1930 Sobel, Mark E., 1527 Worton, Ronald, 391 Solari, Aldo, 1711 van Daalen Wetters, Theodoor, Wreschner, Daniel H., 1759 Soltesz, Ron, 1518 250 Wu, Jin-Shyun R., 1792 Sompayrac, Lauren, 484 van Straaten, Flip, 914 Wunderlich, Frank, 693 Sompayrac, Lauren M., 290 Vande Woude, G. F., 305 Soprano, Kenneth J., 214 Van'T Hof, Jack, 172 Yamaizumi, Masaru, 511 Sorge, Laurie K., 1718 Vecchio, Giancarlo, 2099 Yamamoto, Keith R., 149, 551 Spevak, Walter, 1545 Verma, Inder M., 914, 1062 Yang, Ning-Sun, 982 Srinivasan, Parithychery R., 1053 Villanueva, Julio R., 2287 Yenofsky, Richard, 1197 Stacks, Pamela C., 1403 Villarreal, Luis P., 1381 Yeung, Cho-Yau, 819 Stadler, Joan K., 1634 Vitto, Louise, 2066 Yoder, John I., 956 Stallcup, Michael R., 1310 Vogt, Volker M., 635 Yoder, Sharon S., 819 Stallings, Raymond L., 1967 Vuust, Jens, 1527 Yonemoto, Wes, 9 Standring, David N., 1766, 1774 Young, Dallan, 720 Stark, George R., 2076, 2089 Young, Elton T., 20, 360 Steinmetz, Dennis, 1488 Wahl, Geoffrey M., 2066 Youngner, Julius S., 1533 Stenberg, Richard M., 1235 Wallace, R. Bruce, 750 Yu, Jian-Kang, 1246 Stieber, Anna, 91 Wan, Katherine M., 182 Strathern, Jeffrey N., 803 Wang, Eugenia, 1656 Stratowa, Christian, 1032 Wang, Jean Yin Jen, 773 Zakian, Virginia A., 1898 Strausberg, Susan, 1625 Wang, Yuan, 1032 Zannis-Hadjopoulos, Maria, 421 Subramani, Suresh, 1040 Wantyghem, Josiane, 1138 Zassenhaus, H. Peter, 1615 Sugiyama, Ruth H., 1937 Ward, David C., 1567 Zieg, Janine, 2076, 2089 Summers, Max D., 2156 Warner, Jonathan R., 457 Ziegler, Steven F., 596 Swyryd, Elizabeth A., 2089 Wasmuth, John J., 429, 761, 892 Zipser, David, 1815 Szostak, Jack W., 747 Wasternack, Claus H., 613 Zuker, Charles, 1511 SUBJECT INDEX VOLUME 3 Abelson murine leukemia virus AROI homologous cellular RNA, 773 cluster gene in S. cerevisiae, 1609 monoclonal antibodies to transformed cell phospho- ARS sequences tyrosine, 1343 mouse chromosomal DNA, in yeasts, 1898 transformed cell lines lacking a phosphoprotein, 56 a-Satellite array Abelson virus interruption by monkey KpnI DNA, 967 infected lymphocytes, 596 Asparagine phototrophs Acid phosphatase 5-azacytidine induced, 1937 physiological control in S. cerevisiae, 839 Asparagine synthetase Actin CHO cell overproducers, isolated with albizziin, 391 human types, genes, 1783 in 5-azacytidine-induced Jensen rat sarcoma cells, linked genes in sea urchin, 448 1937 mRNA levels affected by changes in cell configura- Aspergillus nidulans tion, 182 amdS gene, 1430 mRNA production in rat brain, regulation, 1333 Aspergillus spp. mRNAs for human, cDNA clones, 787 5-azacytidine effects, 2287 sea urchin, genes, organization and evolution, 1824 fluffy phenotype conversion, 2287 synthesis in cytochalasin D-treated cells, 132 Autographa californica nuclear polyhedrosis virus Adenine expression vector for human beta interferon, 2156 in adenine phosphoribosyltransferase-deficient cells, Avian leukosis virus 82 lymphomas, immunological phenotype, 1077 kinetics in L929 and CHO cells, 82 Avian reticuloendotheliosis virus Adenine phosphoribosyltransferase cloning vectors, helper cell line, 2241 deficient mammalian cells, adenine transport in, 82 Avian sarcoma virus Adenovirus type 2 regulatory elements in long terminal repeat, 1975 cellular gene expression, control during infection, RNA polymerase II promoters in long terminal 819 repeat, 811 effect on host mRNA metabolism, 1212 5-Azacytidine VAI RNA gene promoter components, 1996 asparagine-independent Jensen rat sarcoma cell var- Adenovirus type 5 iants, 1937 ElAa protein, localization, 829 fluffy phenotype in treated Aspergillus spp., 2287 EIA control of gene expression, 1222 Ela control of transcription in X. laevis oocytes, 2131 Baculovirus infection, effects on HeLa cell rRNA, 662 expression vector for human beta interferon, 2156 SS-B/La nuclear antigen, phosphoprotein, 1235 P-Globin ADRI gene promoter, enhancer effects in mouse cells, 1246 regulatory, S. cerevisiae, 360 Bovine papilloma virus S. cerevisiae, isolation and characterization, 360 gene activator, 1108 a-Fetoprotein stable hybrid plasmid for dominant selective trait, mouse minigenes, 1295 2110 African green monkey DNA vector bearing human interferon B, gene, 233 library substituting for signals in thymidine kinase vector enhancing hepatitis B surface antigen pro- gene, 643 duction, 1032 polyadenylation signals, 643 Brain, rat Albizziin cytoskeletal mRNAs in development, 1333 isolation of CHO cell asparagine synthetase over- producers, 391 resistance in CHO cells linked to gene amplification, Calcium 391 deprivation for arrest of polyamine synthesis, 480 Alcohol dehydrogenase Calmodulin transposable element-associated mutations in S. phosphorylated form, 1412 cerevisiae, 20 Catalase T Alu sequences S. cerevisiae structural gene, 1545 Z-DNA sequence in, 960 Catenation amdS DNA, in vivo, 126 Aspergillus nidulans, 1430 CDC8 gene Ammonia S. cerevisiae, cloning, 1730 regulation of amino acid permeases in S. cerevisiae, cDNA 672 Dictyostelium germination-specific clones, 1943 aprt full-length human actin, clones, 787 CHO cell locus, mechanism of mutation at, 1703 sequences from sea urchin embryos, 1021

v vi SUBJECT INDEX MOL. CELL. BIOL. Cell configuration Cycloheximide role in regulating actin mRNA, 182 resistant T. thermophila mutant with altered growth c-fms oncogene properties, 503 transcription during mouse development, 1062 Cytochalasin B c-fos gene altered cell spreading, 113 FBJ murine osteosarcoma virus v-fos homolog, 914 Cytochalasin D Chicken embryo limb bud cells actin synthesis in HEp-2 cells, 132 viral infection of chondroblasts, 1518 Chinese hamster ovary cells, unstable resistance, Chimeric plasmids 1634 simian virus 40-hepatitis B virus, 2250 Cytomegalovirus Chinese hamster cells DNA sequence hybridizing with mammalian ele- albizziin selection ofasparagine synthetase overpro- ments, 1389 ducers, 391 repetitive cell DNA sequence in, 1389 amplification of dihydrofolate reductase gene in Cytoskeleton DHFR- cells, 1274 glycoconjugates association with, 684 amplified dihydrofolate reductase sequences, 699 mRNAs and brain development, 1333 aprt locus, mechanism of mutation, 1703 Cytoskeleton, cellular autosomal loci, mutation, 1172 herpesvirus proteins, localization, 315 chromosomal assignment of CHO cell enzyme loci, 1967 chromosomal rearrangements in CHO cells, 1967 dihydrofolate reductase gene, phenotypic rescue, 1266 Deletion mutants diphtheria toxin, fate in resistant cells, 1283 F8dl, in study of simian virus 40 transformation, 290 emetine-resistant mutants, proteins in, 190 simian virus 40 A gene, proteins encoded, 220 EmtA EmtB double mutants, 761 Desmin emtA, emtB, emtC mutants, distinction, 429 degradation by specific protease, 1146 formycin B-resistant CHO mutant cells, 1468 Dibutyryl cyclic AMP HGPRT locus, deletion, amplification, 1086 resistant mutants from cAMP-dependent mutants, increased mutation in serially selected ovary cells, 250 1882 Dictyostelium discoideum multiple independent emetine resistance genes, 198 membrane glycoprotein gp80, monoclonal antibody, ribosomal protein S14, 190 863 thymidine kinase gene, 1815 nuclear transit times for different mRNAs, 1511 transfer of human genes into CHO cell mutants, 892 spore germination-regulated DNA sequences, 1943 unstable multidrug cross-resistance, 1634 transformation, TI Chitin Dihydrofolate reductase deposition in S. cerevisiae cdc mutants, 922 chimera, constructed, 32 Chlamydomonas reinhardi engineered mouse minigenes, 257 toluenized, cell cycle transcription, 1537 gene amplified by transfer to DHFR- cells, 1274 Cholera toxin gene expression, adenovirus type 2 control, 819 endocytosis by neuroblastoma cells, 91 gene identified by phenotypic rescue, organization, Chondroblasts, presumptive 1266 chick limb bud, viral infection, 1518 genes from DHFR cDNA segment, 1598 Chromatin Harvey sarcoma virus long terminal repeat, marker structure formed by simian virus 40-pBR322 plas- constructed, 32 mids, 2203 mRNA, growth-dependent expression, 1598 Chromosome mRNA, processing in mouse fibroblasts, 1792 mediating transfer of hydroxyurea resistance, 1053 transfected and amplified sequences in CHO cells, new one for S. cerevisiae, 415 699 Cleavage Diphtheria toxin mouse pre-rRNA, 1501 fate in toxin-resistant hamster and mouse cells, 1283 Collagen DNA inhibition of synthesis by phorbol esters, 1527 African green monkey, library, 643 Core histone mRNA amplified in N-(phosphonacetyl)-L-aspartate-resist- accumulation in sea urchin embryos, 974 ant hamster cells, 2076 COS-1 cells binding properties of simian virus 40 replication- chromatin structure formed by plasmids, 2203 defective mutants, 1958 Cos-l cells binding protein in Ustilago maydis, 605 polyadenylation, processing analyzed with tk gene, catenation, decatenation in vivo, 126 267 cytomegalovirus, repetitive cell sequence in, 1389 c-rasKi oncogene D. melanogaster, organization at cuticle locus, 1724 transcription during mouse development, 1062 extrachromosomal, of pea, 172 CUP] region germ line-specific in Tetrahymena, 1909 tandem gene iteration in industrial yeasts, 1353 hybridization with mouse intracisternal A particle Cyclic AMP genes, 1371 dependent protein kinase mutant, reversion, 250 mitochondrial, and oligomycin resistance, 1694 VOL. 3, 1983 SUBJECT INDEX vii Moloney sarcoma virus proviral, transforming activ- hepatitis B virus gene with recombinant plasmid ity, 305 vectors, 143 mouse chromosomal sequences, ARS function in human histone gene, regulation, 539 yeasts, 1898 human interferon B, gene, bovine papilloma virus porcine major histocompatibility sequences, expres- vector, 233 sion, 2006 S. cerevisiae mitochondrial tRNA gene, 371 procaryotic, inhibits mammalian cell transforma- thymidine kinase gene in TK- mouse cells, 511 tion, 956 rearrangements in Trypanosoma antigenic variation, 399, 410 FBJ murine leukemia virus repetitive, associated with major histocompatibility genome structure, 914 genes, 903 helper virus, 914 replication forms in hypotrichous ciliates, 1562 Fibroblasts replication, inhibition by hydroxyurea in mouse Abelson murine leukemia virus-transformed, lack- cells, 297 ing phosphoprotein, 56 S. cerevisiae cdc2 mutant, stably denatured regions, altered cell spreading in cytochalasin B, 113 1665 antibody modulation of proteins in virus-infected, simian virus 40, UV-damaged, pyrimidine in, 1403 1580 tightly bound to protein in HeLa cells, 1567 chick, mitogen stimulation of phosphotyrosine in, transfected, homologous recombination between, 380 1680 Filaments Double-stranded RNA intermediate, in fibroblasts in cytochalasin B, 113 M2, exclusion in S. cerevisiae killer systems, 654 Formycin B Drosophila melanogaster Chinese hamster ovary cells, resistant mutants, 1468 glue protein genes, location, 623 Friend spleen focus-forming virus heat shock alters ribonucleoproteins, 161 viral transforming function in thymidine kinase vec- highly conserved heat shock protein genes, 1540 tors, 2191 larval cuticle locus, DNA structure, 1724 Fusion polytene chromosome puff, glue protein genes, 623 spontaneous, normal host and tumor cells, 523 S6 protein, dephosphorylation in heat shock, 2017

Genetic map distances E1Aa protein equation to determine from tetrad data, 1886 localization in adenovirus-infected cells, 829 Gene transfer EIA gene, adenovirus human into CHO, efficient procedure, 892 gene expression control, mediation of, 1222 Globin, a and a Eco gpt regulation of mRNA, 229 glucocorticoid regulation, 1421 Glucocorticoid hormones mouse mammary tumor virus fusion plasmid, 1421 dependent adult liver cell line, 1013 Embryonal carcinoma cells modulate murine mammary tumor virus transcrip- human-mouse teratocarcinoma hybrids, 2259 tion, 551 muscle differentiation, 2280 regulation of gene expression, 149 neural differentiation, 2271 regulation of mouse mammary tumor virus expres- Emetine sion, 2045 multiple resistance genes in Chinese hamster cells, response variants, immunological selection, 1310 198 Glue proteins resistant CHO cells, ribosomal protein S14, 190 Drosophila, chromosome location, 623 EmtA EmtB double mutants Glycoconjugates Chinese hamster cells, construction, 761 association with cytoskeletal framework, 684 emtA, emtB, emtC GM, ganglioside Chinese hamster cells, distinction, 429 exogenous, endocytosis by neuroblastoma cells, 91 Epithelial keratins Growth regulation tissue specificity, 495 melanoma cells, by interferon, 780 Erythroleukemia cells, mouse differentiating, mRNA regulation in, 1197 Escherichia coli Harvey murine sarcoma virus f-galactosidase produced in S. cerevisiae, 1625 long terminal repeat in simian virus 40 recombinant, lacZ fused to S. cerevisiae HSP9O, 1625 325 lacZ fused to S. cerevisiae leu2, 580 Harvey sarcoma virus retrovirus gag gene expression, 1746 dominant, selectable marker constructed, 32 Euglena gracilis long terminal repeat chimera, 32 uracil compartmentation, 613 Heat shock Euplotes eurystomus gene, human, during adenovirus infection, 2058 DNA replication forms, 1562 regulated production ofE. coli protein in S. cerevisi- Expression ae, 1625 cDNA inserts, new cDNA cloning vector, 280 response in Drosophila, 2017 viii SUBJECT INDEX MOL. CELL. BIOL. ribonucleoprotein assembly altered in Drosophila, Insect cells 161 human beta interferon, baculovirus vector, 2156 Heat shock proteins Interferon cytoplasmic granules in tomato cells, 1648 ,B gene, inducible expression, 233 highly conserved mouse and Drosophila genes, 1540 growth regulation of melanoma cells, 780 simian virus 40-induced, 1 human, baculovirus vector, in insect cells, 2156 HeLa cells inhibition of pinocytosis, 1533 histone mRNAs, synthesis and accumulation, 539 mRNA breakdown in treated HeLa cells, 64 protein synthesis despite mRNA breakdown from pp6OSrc synthesis in virus-transformed rat cells, re- interferon, 64 duced, 1656 tightly bound DNA-protein complexes, 1567 resistant cell line, 1759 Helper cell line Intracisternal A particles avian reticuloendotheliosis virus cloning vectors, methylation, rearrangement of mouse genes, 1371 2241 Invertase construction, 2241 S. cerevisiae, SUC2 mRNAs, 439 Hepatitis B virus lontophoresis RNA polymerase II transcript encoded, 1774 microinjection of DNA, 1803 transcription by RNA polymerase II, 1766 Isozyme Hepatitis B virus surface antigen plasminogen activator, effect of extracellular ma- enhanced production with bovine papilloma virus trix, 982 vector, 1032 gene expression studied with new host-vector sys- tem, 143 gene, processing and polyadenylation signals, 2250 Karyoplasts plasmid-directed synthesis in monkey cells, 44 macromolecular synthesis, 1866 Killer toxin Herpes simplex virus S. cerevisiae, secretion, 1362 a and fy gene expression, 2028 effect on Vero cell microfilaments, 712 Kirsten murine sarcoma virus nuclear localization of proteins, 315 ras in 3-methylcholanthrene-transformed cells, 2298 Heterogeneous nuclear RNA ts mutant, transformation of rat thyroid cells, 2099 dihydrofolate reductase, delayed processing, 1792 KpnI DNA Histone mRNA interruption of a cloned monkey a-satellite array, serum-stimulated mouse fibroblasts, 1920 %7 H-2Kb antigen gene identified by hybridization with oligonucleo- tides, 750 Lectins HI mRNA resistant rat skeletal myoblast mutants, 2166 accumulation in sea urchin embryos, 974 Leishmania enrietii HTC cells tubulin gene arrangement, 1070 mutants defective in glucocorticoid-regulated gene Liver expression, 149 regulation of mouse major urinary protein gene, Human a-tubulin 2232 gene expression, 1738 Liver cells, adult Human P-tubulin glucocorticoid-dependent cell line, 1013 isotypes identified, 854 Liver hepatoma cells, rat Human epithelial cells rat growth hormone gene, inactivity, 1460 tissue specificity of keratins, 495 Long terminal repeats Human hepatoma cell line mouse VL30 gengs, 2221 plasma protein secretion in new cell line, 1133 L6 rat myoblasts Hybrids myogenesis and RNA polymerase II mutations, 946 human-mouse teratocarcinoma lines, 2259 Lymphocytes Hydroxyurea Abelson virus-infected, 5% chromosome transfer of resistance, 1053 Lymphomas enhancement of resistance and gene amplification, avian leukosis virus-induced, immunoglobulin, 1077 1097 mechanisms of DNA replication inhibition in mouse cells, 297 Hypoxanthine-guanine phosphoribosyltransferase Macromolecular synthesis HGPRT locus in Chinese hamster cells, 1086 regenerating karyoplasts, 1866 Major histocompatibility genes repetitive DNA associated with, 903 Major urinary protein genes, mouse regulation in liver, 2232 Immunoglobulin heavy-chain locus MAL gene family productive and sterile transcripts, 1317 maltose fermentation in S. carlsbergensis, 7% Industrial yeasts Measles virus tandem gene iteration at CUP] region, 1353 effect on Vero cell microfilaments, 712 VOL. 3, 1983 SUBJECT INDEX ix Metastasis sea urchin, Hl and core histone, 974 spontaneous fusion of normal host and tumor cells, sea urchin, pluteus, sequences cloned, 1021 523 translatable, modulated by platelet-derived growth Methylation factor, 1478 inhibits transforming activity of cloned Moloney tubulin, actin in rat brain, 1333 sarcoma virus DNA, 305 utilization in differentiating erythroleukemia cells, 3-Methylcholanthrene 1197 transformed cells, presence of ras oncogene, 2298 Murine erythroleukemia cells Microfilaments a- and 0-globin gene regulation, 229 Vero cell, effects of virus infection, 712 Murine leukemia virus Microinjection provirus in radiation-induced mouse thymoma cells, iontophoretic, for DNA transformation, 1803 1675 purified pp6fsrc, 102 Muscle TK gene-polyomavirus DNA plasmids in mouse differentiation in embryonal carcinoma cells, 2280 cells, 511 Mutagenesis Minigenes simian virus 40, unrelated to transformation, 421 mouse, a-fetoprotein, expression, 1295 Myogenesis mouse, dihydrofolate reductase, 257 effects of RNA polymerase II mutations, 946 Mitochondria S. cerevisiae, gene expression, 371 Mitochondrial DNA Neuroblastoma cells analyzed in oligomycin-resistant mouse cells, 1694 endocytosis of cholera toxin and GM, ganglioside, Mitochondrial RNA 91 S. cerevisiae varl, 1615 Nucleoside transport function Mitogen purine biosynthesis and salvage in murine cells, stimulated chick fibroblasts, tyrosine phosphoryla- 1187 tion in, 380 Nucleosomes Moloney sarcoma virus regular arrangement on Xenopus 5S rRNA genes, transforming ability inhibited by methylation, 305 720 Monoclonal antibody D. discoideum membrane glycoprotein gp8O, 863 phosphotyrosyl proteins, 1343 Oligonucleotides Mouse-human hybrid cells hybridization with H-2Kb gene, 750 expression of human Ul small nuclear RNA, 2211 Oxalurate Mouse lymphoid cells induction of multiple URA3 transcripts in S. cerevi- selection, glucocorticoid responsiveness, 1310 siae, 1889 Mouse mammary tumor virus Eco gpt fusion plasmid, Eco gpt expression, 1421 gene product expression for immunological selec- Paramecium tion, 1310 surface protein genes, 466 glucocorticoid regulation of promoter, 2045 pBR322 Mouse VL30 genes simian virus 40 recombinant plasmids, chromatin structure, expression, 2221 structure, 2203 mRNA p53 cellular antigen decay in interferon-treated, virus-infected HeLa regulatory mechanisms, 2143 cells, 64 Pea (Pisum sativum) dihydrofolate reductase, delayed processing, 1792 extrachromosomal DNA, 172 dihydrofolate reductase, from cDNA genes, 1598 mRNA for ribulose-1,5-bisphosphate carboxylase, encoding S. cerevisiae invertases, 439 587 heat shock-induced mouse, conserved, 1540 Permease histone, accumulation during HeLa cell cycle, 539 S. cerevisiae, amino acid specific, ammonia regula- histone, in serum-stimulated fibroblasts, 1920 tion, 672 host, adenovirus effect on, 1212 Phosphocalmodulin human actins, cDNA clones, 787 chicken brain and muscle, 1412 human heat shock, during adenovirus infection, N-(Phosphonacetyl)-L-aspartate 2058 amplified DNA in resistant Syrian hamster cells, keratin, two families in human epithelial cells, 495 2076 liver-specific, transcription in hepatocytes, 1552 CAD genes in resistant Syrian hamster cells, 2066 major urinary protein, mouse, levels in liver, 2232 single-step mutants of resistant Syrian hamster meiosis-specific in Tetrahymena, 1857 cells, 2089 nuclear transit times in D. discoideum, 1511 Phosphotransferase p53, mechanisms regulating, 2143 specific activity of pp6fl-src, 1589 precursors encoding A chain forms, 1317 Physarum polycephalum procollagen, in procollagen synthesis, 241 extrachromosomal rDNA, inheritance, 635 ribulose-1,5-bisphosphate carboxylase in pea plants, Phytohemagglutinin A 587 resistant rat skeletal myoblast mutants, 2166 x SUBJECT INDEX MOL. CELL. BIOL. Pinocytosis PUN inhibition by interferon, 1533 S. cerevisiae, proline utilization, 1846 Plasma proteins Pyrimidine induction in new hepatoma cell line, 1133 dimers in UV-damaged SV40 DNA, 1403 Plasmids cDNA cloning vector in mammalian cells, 280 mouse mammary tumor virus-Eco gpt, mouse cells, Rat growth hormone gene 1421 inactivity in liver tumor cells, 1460 multiple, tandem integration in S. cerevisiae, 747 Rat skeletal myoblasts polyomavirus recombinants with transforming po- lectin-resistant mutants, 2166 tential, 1670 rDNA simian virus 40-based, hepatitis B surface antigen mouse, sequences, 1488 gene, 44 Recombination stable, bovine papilloma virus, 2110 monkey cells, homologous and nonhomologous, thymidine kinase gene-polyomavirus DNA, in 1040 mouse cells, 511 Retinoic acid to express hepatitis B surface antigen gene, 143 induced muscle differentiation, 2280 Plasminogen activator induced neural differentiation, 2271 isozyme activities, effect ofextracellular matrix, 982 Retrovirus Platelet-derived growth factor transduction studies, 2180, 2191 cell proteins modulated by, 70 Reversion translatable mRNAs, modulated, 1478 S49 cell cAMP-dependent protein kinase mutant, Polyadenylation 250 signal in tk substituted by monkey DNA library, 643 Ribonucleoproteins signals in Cos-1 cells analyzed with tk gene deriva- ribosomal, nuclear transport in Tetrahymena, 693 tives, 267 structure altered by heat shock in Drosophila, 161 Polyamine Ribosomal proteins synthesis, arrest, 480 ribonucleoprotein export from Tetrahymena nuclei, Polyomavirus 693 DNA effects on thymidine kinase gene expression in S. cerevisiae, effects of mild temperature shock, 457 TK- mouse cells, 511 Ribosomal ribonucleoproteins DNA-thymidine kinase gene recombinant plasmids, temperature effects on transport in Tetrahymena, 511 693 early proteins in tumorigenesis, 1451 Ribulose-l,5-bisphosphate carboxylase heat shock protein synthesis in permissive cells, I gene and mRNA, pea plants, 587 plasmid recombinants with transforming potential, RNA 1670 simian virus 40 splicejunction deletion mutant, 1381 Porcine major histocompatibility DNA splicing, adenylation, transport, 1381 expression in mouse L cells, 2006 RNA polymerase II ppr60csrc a-amanitin resistance mutations, effects on myogen- high levels in neural tissues, 1157 esis, 946 P1P4-di(adenosine-5')tetraphosphate hepatitis B virus transcription, 1766 inhibition of pp6OSrc kinase, 1718 initiation of runoff transcripts, 2172 pp60Src pausing and termination of transcription, 1687 adhesion plaque location on transformed cells, 731 promoters in avian sarcoma virus long terminal association with pp9O and pp5O in transformed repeat, 811 chicken cells, 9 transcript encoded by hepatitis B virus, 1774 cytoskeletal proteins phosphorylated, 102 RNase kinase, inhibited by P',P4-di(adenosine-5')tetra- multiple types in X. laevis oocytes, 1711 phosphate, 1718 Rous sarcoma virus microinjected, induces actin transformation, 102 gag gene expression in E. coli, 1746 synthesis in virus-transformed rat cells reduced by pp60's, association with chicken cellular proteins, 9 interferon, 1656 pp6Osrc localization in transformed cells, 731 pp6Ov-src pp60v-s7c specific activity increased, 1589 phosphotransferase specific activity increased, 1589 transcriptional elements within long terminal repeat, Prepro-a-factor pheromone 1834 different yeasts, 1440 transformed rat cells, reduced pp60Orc in, 1656 Pre-rRNA, mouse rRNA cleavage sites, 1501 co-amplification with CAD genes in Syrian hamster Procollagen cells, 2066 mRNA control of synthesis, 241 extrachromosomal, inheritance in Physarum poly- Protein kinase cephalum, 635 S49 cell cAMP-dependent mutant, reversion, 250 HeLa cells, adenovirus infection effects, 662 substrate for tyrosine-specific, 340 mitochondrial in glucose-repressed S. cerevisiae, Protein synthesis 1949 in spite of mRNA breakdown, 64 5S genes in Xenopus, nucleosome arrangement, 720 VOL. 3, 1983 SUBJECT INDEX xi

Runoff transcripts deletion mutant F8dl able to transform mouse cells, initiation and formation, 2172 290 deletion mutants that transform with reduced effi- ciency, 484 Saccharomyces carlsbergensis early- and late-region promoter functions enhanced, MAL gene family, 7% 991 Saccharomyces cerevisiae heat shock protein synthesis in permissive cells, I ADRI gene, isolation and characterization, 360 induction stimulated by 12-O-tetradecanoylphorbol alcohol dehydrogenase expression, 20 13-acetate, 757 ammonia regulation of amino acid permeases, 672 pBR322 recombinant plasmids, chromatin structure, AROI cluster gene isolated, 1609 2203 catalase T structural gene, 1545 recombinant virus containing Harvey sarcoma virus CDC8 gene cloned, 1730 LTR, 325 cdc2 mutant, stably denatured chromosomal DNA, regulatory-deficient natural recombinants, 1930 1665 splice junction deletion mutants, RNA structure, chitin deposition in cdc mutants, 922 1381 chromosome III ring derivative, 803 T-antigen gene deletion mutants, 214, 220 E. coli 0-galactosidase produced in, 1625 T-antigen mutants defective in DNA replication, exclusion of M2 double-stranded RNA, 654 1958 gene product function during cell division, 1255 T antigen, mutational analysis, 203, 214 HSP90-E. coli lacZ fused gene, 1625 transformed rat tumor cells, 1138 invertase production and SUC2 mRNA, 439 tumor antigens, related to mutagenesis, 421 killer systems, 654 UV-damaged, pyrimidine dimers in, 1403 killer toxin glycosylated precursor, 1362 Small nuclear RNA killer toxin secretion, 1362 synthesis, sensitivity to UV, 2151 leu2 fused to E. coli 0-galactosidase gene lacZ, 580 Ul, location and expression, 2211 mitochondrial rRNA in glucose repression, 1949 SS-B/La antigen mitochondrial tRNA gene, expression, 371 adenovirus, associated phosphoprotein, 1235 mitochondrial varl gene, transcriptional analysis, Styx sp. 1615 DNA replication forms, 1562 mitotic recombination, 1204 Substrates multiple, tandem plasmid integration, 747 tyrosine-specific protein kinase, location, 340 new chromosome, 415 SUC genes oxalurate induction of multiple organization in Saccharomyces spp., 351 URA3 transcripts, 1889 Syrian hamster cells physiological control of repressible acid phospha- amplified CAD genes, 2066 tase, 839 amplified DNA in N-(phosphonacetyl)-L-aspartate- plasmid recombination reduced by sequence hetero- resistant lines, 2076 geneity, 1204 neoplastic conversion rate, 931 prepro-a-factor gene, 1440 single-step mutants, 2089 PUT2 for protein utilization, 1846 repressible acid phosphatase genes, 5'-end analysis, 570 T antigen, simian virus 40 repressible acid phosphatase genes, mapping, 562 deletion mutant-encoded, activity, 220 ribosomal protein genes in mild temperature shock, deletion mutants, functions, 214 457 DNA replication-defective mutants, 1958 SAD, an extra a cassette, 871 mutational analysis, 203, 214 S-phase-defective cdc2 mutants, 1000 Temperature start genes CDC36, CDC37, CDC39, 881 effects on ribosomal ribonucleoprotein transport in SUC genes, organization, 351 Tetrahymena, 693 SUC2 mRNA, 439 Tetrad data transposable element-associated mutations, 20 equation to determine genetic map distances from, Saccharomyces spp. 1886 maltose fermentation: S. carlsbergensis MAL genes, 12-O-Tetradecanoylphorbol 13-acetate 796 inhibition of collagen synthesis, 1527 prepro-a-factor genes, 1440 stimulation of simian virus 40 induction by DNA SUC genes, 351 damage, 757 Sea urchin Tetrahymena thermophila actin gene family, 1824 conjugation-specific mRNAs, 1857 Hl and core histone mRNAs, 974 cycloheximide-resistant mutant, altered growth, 503 linked actin genes, 448 germ line-specific DNA on micronuclear chromo- pluteus embryo mRNAs cloned, 1021 somes, 1909 Simian virus 40 nuclear transport of ribosomal ribonucleoprotein, A gene deletion mutants, coded proteins, 220 693 72-base-pair repeat, requirement for transcription, ribosome mutant, 503 991 Thymidine kinase gene xii SUBJECT INDEX MOL. CELL. BIOL. Chinese hamster, isolation and characterization, polyomavirus early proteins, 1451 1815 Tumor promoters effects of polyomavirus DNA on expression in TK- sensitivity transferred by DNA transfection, 1182 mouse cells, 511 Tyrosine phosphorylation hypermethylation, 1163 increased in mitogen-stimulated chicken embryo monkey DNA substituted for polyadenylation sig- fibroblasts, 380 nal, 643 of vinculin, timing, 475 plasmids containing, expression in mouse cells, 511 Tyrosine protein kinase substrate retrovirus deletion vectors for transduction studies, lacking in Abelson murine leukemia virus-trans- 2191 formed cells, 56 temperature-sensitive cell lines after transfer, 490 Thymomas, mouse murine leukemia virus provirus, 1675 URA3 Thyroid cells, rat multiple transcripts in S. cerevisiae, 1889 transformed by ts Kirsten murine sarcoma virus, Uracil 2099 compartmentation in Euglena gracilis, 613 tk gene Ustilago maydis monkey DNA substituting for processing/polyaden- DNA-binding protein that prefers uninterrupted du- ylation signal, 643 plex DNA, 605 polyadenylation signals in Cos-I cells analyzed UV radiation with, 267 sensitivity of small nuclear RNA synthesis, 2151 Tomato cell cultures heat shock granules, cytoplasmic, 1648 Transcription VAI RNA, adenovirus adenovirus, regulation by X. laevis Ela gene, 2131 promoter components, 1996 analysis of S. cerevisiae varl, 1615 Vectors chromosomal position, effects, 551 baculovirus, human interferon in insect cells, 2156 glucocorticoids, effect, 551 bovine papilloma virus, hepatitis B surface antigen, heptatitis B surface antigen gene, 2250 1032 liver-specific gene in mouse hepatocytes, 1552 bovine papilloma virus, human interferon B, gene, murine mammary tumor virus, modulated, 551 233 of hepatitis B virus by RNA polymerase II, 1766 for cloning cDNAs in E. coli, 280 regulatory elements in Rous sarcoma virus, 1834 new recombinant, hepatitis B virus gene, 143 RNA polymerase II, termination, 1687 retrovirus, exogenous genes in mammalian cells, toluenized Chlamydomonas reinhardi cells, 1537 1123 Transduction retrovirus-thymidine kinase, transduction studies, deletion and recombination in generated retrovir- 2191 uses, 2180 Vesicular stomatitis virus retrovirus-thymidine kinase vectors, 2191 antibody-induced modulation in infected cells, 1580 Transformation Vimentin by simian virus 40, role of p53 antigen, 290 degradation by specific protease, 1146 D. discoideum, by mammalian-cell plasmid, 2117 Vinculin enhanced, simian virus 40-Harvey sarcoma virus phosphorylation on tyrosine hybrid, 325 mammalian cell, inhibited by procaryotic DNA, 956 Moloney sarcoma virus, inhibited by methylation, 305 Wheat germ agglutinin pp60Sc localization in cells, 731 resistant rat skeletal myoblast mutants, 2166 S. cerevisiae ribosomal protein genes, 457 simian virus 40, reduced-efficiency deletion mu- tants, 484 Xenopus laevis Transposable elements adenovirus transcription regulated by Ela gene, mutations in S. cerevisiae alcohol dehydrogenase, 2131 20 multiple RNases in oocytes, 1711 Trypanosoma equiperdum nucleosomes on 5S rRNA genes, 720 antigenic variation, 399, 410 tRNA-processing enzymes in oocytes, 1711 DNA rearrangements, 399, 410 variant surface glycoprotein gene, 410 Tubulin Yeasts Leishmania enrietii, gene arrangement, 1070 mouse sequences with ARS function, 1898 mRNA regulation in rat brain, 1333 Tumor cells spontaneous fusion with normal host cells, 523 Z-DNA Tumorigenesis potential sequence in Alu, 960 1984 Full Membership American Society for Microbiology 1913 I St., NW, Washington, DC 20006

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