The Newsletter of the NIH Alumni Association

Spring 1996 Vol. 8, No.1 date Furlough, Snow Bollix Report Plots Future of Campus Routine Clinical Center

When many NIH employees flocked By Sara Byars back to campus on Thursday. Jan. 11, after nearly 3 weeks of furlough and The Clinical Center should change nearly a week of snow-forced govern­ tJ1e way it's governed. funded. and ment closure, it was with the blinking, managed in order to provide a stable befogged status of refugees returning foundation for clinical research into the from forced ex ile. They staggered into next century, according to recommen­ work concerned that an evening snow dations contained in an extensive repon forecast would materialize into another to HHS Secretary Donna ShaJala delay because of the long weekend released Feb. 9. capped by the Martin Luther King. Jr. The repon summarized findings of holiday. an option team that had a mandate to It did snow that night, and NIH evaluate how best to structure the didn't fully reopen until Tuesday, Jan. Florence S. Mah oney Clinical Center and its operati ons. ''The 16. when the entire workforce returned recommendations contained in this to face bli zzards of traffic and paper­ Florence Mahoney report will allow the Clinical Center 10 work. lndeed, many were too snowed Chosen 1996 Public remain in the forefront of biomedical under with work to answer calls from research into the new century,·• said Dr. reporters and grantees, but around the Service Awardee John Uall in, CC dire~tor and a member water cooler. the stories were shared: of the team that examined and evaluat­ some colleagues used to advantage The NIH Alumni Association·s ed CC operations for nearly a year. He almost 4 weeks of paid leave-at no board of directors has chosen Florence said that ·'the recommendations in no charge to their leave balances-at the Stephenson Mahoney as the recipient way suggesr thar Clinical Center jobs best possible time of the year-the hol­ of its Public Service Award for 1996. are in jeopardy or that CC services will iday season. She will receive the award at tJ1e group's universally be contracted out" The budget crisis shocked NIH . annual meeting on Saturday, June 15, (See CC Update p. 19) Investigators ran out of supplies mid­ 1996. This is the fourth year that this experiment and weren ' t allowed to pro­ honor has been presented. The previ­ cure new materials. Grant money to ous awardees were the late Congress­ In This Issue Page universities was held up (see accompa­ man William H. Natcher, Dr. P. Roy NIH recefres budget increase J nying sidebar). Paychecks were cut in Vagelos, and Dr. Maxine F. Singer. Research Festfral ·95 lreld half. putting many workers in crisis Florence Mahoney has been a nation­ at Natclrer 4 when bills, especially for housing, ally influential supponer of medical Calendar 5 came due. Commissioned Corps mem­ research since pre-World War Il years. News from and a/10111 NIHAA members 6 bers were plunged into tunnoil when A former newspaper woman, she was A ll'ller from NlliAA presidem II their furlough-exempted status as emer­ appalled at the furtive attitudes among Memorial e1·c111s far A11fi11se11 arrd gency workers played havoc with long­ well-read people about mental health Ste11e11 12 standing vacation plans. And Clinical problems and by the high rate of rejec­ NIDDK 1111d Pimo l11dia11scelebrate Center employees worked through both tion among military draftees because of 30-yeor study 15 snow and furlough. poor health. She expanded on an early Science Research Updates 17 The campus was surprisingly busy realizarion that the development and /\ closer look at CC elel'Otor arlll'ork 10 during the long layoff, as anyone who application of new knowledge derived NIN Nous 22 visited the NrH Federal Credit Union from medical research is a key factor Mail·i11 ho/lot for board 29 during that period can testify. As the for improvements in human health. At NII/ Retrospectil'es J I (See Furlouglt/Snow p. 18) (See Mahoney p. 2) N I H A A U P D A T E

Mahoney (co11ti1111ed from p. 1) i.cal leaders to discuss research issues that rime, the nature and potential of and possible legislation to advance the medical research was largely unknown cause of NIH, were well recognized for and unappreciated by the public and irs their effectiveness. political representatives. Through her Although publicly less weJJ known The NIHAA Update is the news/euer ofthe newspaper and personal connecrions, than Lasker, the talents ofF lorence NIH Alumni Association. Tile NIHAA office she was well !mown in the Washington Mahoney melded well with the attribut­ is a1 9101 Old Georgetown Rd., Bethesda. scene, especially in Democratic poli­ es of her associare, making them a for­ MD 20814, (301) 530-0567. tics. She began a lifetime effort to per­ midable team. She was a person of her EdiJor's Note suade those individuals with polfrical own mind, however, differing with power of the value of a strong naLional Lasker on occasion and pursuing her The N/HAA Update welcomes letters and news from readers. We wish not only ro medical research endeavor, especially own convictions. [n her own right, she bring al11mni news aho11t NIH, b111 also to through an expanded mission and fund­ was undoubtedly the most influential serve as a means for reporring i11formario11 ing for NIH. backer of the legislation that Jed to the abow alunmi-lheir concerns. i11formario11 on recem appoimments, honors, books pub­ Working closely over the years with establishmenr of the National Institute lished and other developme111s of i111eresr to her colleague, Mary Woodard Lasker. on Aging. She served on the advisory Their colleagues. If you have news abo111 she was highl y i.nstrumental in the pas­ councils of the National Jnstitute of yourself or about other alumni. or com­ menrs on and suggesrions for rhe NIHAA sage of both enabling legislation and Arthri tis and Metabolic Diseases and Update, please drop a note ro rhe ediror. We appropriation biJJ s related ro the com­ NIA and on other national committees. reserve r/1e righr ro edir mareria/s. ponents ofNIH. Her invaluable access Jn 1987, NIA established in her honor to leaders in both executive and legisla­ the annual Florence Mahoney Lecture Editor: Harriet R. Greenwald tive branches of the federal govern­ on Aging, with Dr. Lewis Thomas as NJHAA Newsletter Editorial Advisory ment, her dogged persistence and her the first lecturer. Committee shrewd and well-prepared arguments Florence Mahoney will be honored at on behalf of bener health through sup­ the annual meeting of the Nlli Alumni Jerome G. Green. Chairman Linda J. Brown port of medical research eventually Association at the Mary Woodard Michael M. Gouesman overcame opposition from a variety of Lasker Center (the Cloister). Harriet R. Greenwald sectors. Her low-key dinner parties. Invitations with details about the meet­ \lictoria A. Harden Colleen Henrichsen which brought together top medical ing. which will feature other speakers, Harvey Klein scientists and strategically placed polir­ will be mailed to members in May. Robert G. Marrin Abner Louis Notkins Lois A. Salzman Philip E. Schambrt1 Elizaberh H. Singer SAVE THE DATE! Srorm Whaley Richard G. Wyarr

The Annual Meeting of the NIH Alumni Association NIHAA Newsletter Board of Contributing Editors

Saturday, June 15, 1996 Giorgio Bernardi H. Franklin Bunn Roger 0. Egeberg at the Mary Woodard Lasker Center (the Cloister) Hem)·k Eisenberg Donald S. Fredrickson Bldg. 60, NIH, Bethesda, Md. Lars A. Hanson Walter W. Holland Watch for invitations with details of the program. George Klein Richard M. Krause Robert Q. Marston Thank you and see you in June. Carlos Monge Roger Monier Seymour Perry Michael Sela

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NIH Receives Generous 1996 Budget Increase Those may as well have been dollars the FY 1995 spending level. Even worse, that recently fell across the campus as NIH had been anticipating a I percent snowflakes-top NIH staff were cut from the 1995 level in 1996. and a 3 NIHAA Board ofDirectors a11d Officers delighted when a 5.7 percent increase percent cut from the 1995 level in 1997. over the fiscal year 1995 budget pushed The new budget increases NIH's purse Cah 1ir1 B. Baldwin, Jr.. Presidenr \Villiam I. Gay, Vice Preside/II the agency's FY 1996 budget to a $ 175 million over President Clinton's Joseph Perpich, Vice President shade less than $ 12 billion. own request for the agency-an out­ Storm Whaley. Secreta1y ·'We're real pleased," said Francine come wholly unanticipated during last Harley G. Sheffield. Treasurer Thomas./. Kenned\I, Jr. President 1993­ Little, director of the NlH Office of fa ll 's budget battles on Capitol Hill. 1995 . Financial Management. "With 4 Despite the excellent turnout of the .foe R. field, President 1991 -1993 months of the fiscal year already gone. FY 1996 budget. NLH officials are Gordon D. Wallace. Preside1111990-1991 it's just fantastic news. Everybody reluctant to crow 100 loudly-only Margaret A. Badger around here worked hard for it It·s parts of the HHS empire received fund­ Carl G. Baker grear news for NIH." ing, not all. Noted NIH deputy director William R. Carroll Belia L. Ceja NIH is getting 12 months' worth of Dr. Ruth Kirschstein, "We are pleased Peter Condliffe funding to spend with only 8 months of that the Congress appreciates the impor­ John L. Decker the year left. In some instances, this tance of biomedical research supported Vemh·e Ferguson M11rr<1r Goldstein may result in more generous support of by NIH to the nation's health. but are Williain Goldll'ater research grants. On Jan. 6, 1996. the concerned that other programs re lated Mary Calley Harrmtm budget-good through the end of the to the welfare and public health of the Joseph Keyes, Jr. Tern• L. Lierman fiscal year next Sept. 30-was signed Ameri can people have not yet obtained .lane Leitch by President Clinton. Before that NIH funds for the entire fiscal year.'' Thomas E. Malone had been operating under a Continuing The new budget of $ 11.94 billion Marjorie Melton Charles Miller, II Resolution that limited the operating increases NIH funding some $655 mil­ Bayard Morrison, Ill budget to a few percentage points under lion over the amount spent in FY 1995. Pa11/ Parkman Sey111011r Peny Pa11/ Q. Peterson FY 1995 Mar11in Schneider111a11 ACTUAL FY 1996 PERCENT Randy Schools . BUDGET AUTH. ESTIMATE CA ANGE Helen R. Schroeder ICD TOTAL TOTAL TOTAL Da11id Sco ff Mary E. Sears NCI $ 2. 132.538 s 2.251.084 5.6% John F. Sherman NHLBI 1.295.934 1.355.866 4.6% John P. Ut2 NIDR 174.984 183.196 4.7<;f Eugene Weinbach NIDDK 736.347 771.252 4.7% Bernhard Witkop NINDS 651.523 68153-1 4.6% NIAID 1.095.164 1.169.628 6.8% NIGMS 904.817 946,97 1 4.7% NICHD 568, 136 595.162 4.8% Thank you to the following companjes N'EI 300.318 314. 185 4.6% and individuals who supported NlHAA in NIEHS 272.3 11 288.898 6.1 % 1995: NIA 434.248 453.917 4.5% Boehringer Mannheim Pharmaceuticals NIAMS 231.196 241.828 4.6% Drew Dawn Enterprises. Inc. NIDCD 168.832 176502 4.5% Capitol Associates. Inc. (Terry Liennan) NIMH 630.402 661.328 4.9'k R. 0. W. Sciences. Inc. NIDA 437.176 458.441 4.9% The Institute of Genomic Research NIAAA 189.961 198.607 4.6% NINR 52.74 1 55.831 5.991­ NCRR 349.323 390.339 11.7% We would like to th nnk Glaxo WeUcome NCHGR 152.528 170.041 11 .5% Inc., Sandoz Research l nstiiute and Wyeth­ FIC 23.754 25,313 6.6% Ayerst for underwriting 1hc printing of NLM 127.997 141.439 10.5% NIHAA Update. OD 239.812 261.488 9.0% B&F I 14.120 146.151 28.1~ Thanks also to our members who have TOTAL SI 1.284.162 SI 1.939.00 1 5.8% contributed donations beyond their dues Source: OFM, NIH payment. 3 N I H A A U P D A T E

Research Festival Events Consolidated at Natcher By Carla Garnell

Observing a 9-year rradition. hun­ dreds of NIH 'ers seized the opportunity to check out intramural science at the 1995 NIH Research Festival, held last Sept. 18-22. The venue and format both changed slightly for the annual research event: Symposia, workshops and poster sessions were all held under one roof. Employing the campus's new state-of-the-art meeting facilities, the festi val adopted more of a "mall" con­ cept so attendees could optimize their time and not traverse the campus, hith­ er and yon. "This year, following Dr. Yarmus's suggestion, we tried to consolidate the research ~tctiviLy by bringing the entire scientific program to one location- the Natcher Bldg.," explained Dr. James Battey, director of intramural research at N IDCD and chair of the 1995 research festival advisory committee. Michelle Adams of NIMH and an unidentified colleague discuss the project she worked on This change allowed participants in the with first-time research presenter Matthew Rogel!. festival to observe symposia, multiple workshop presentations, and posters at Clinical Center. tise, talent, and energy that can be the same time, in the same location, for Rookie poster presenter Matthew found in the intramural research pro­ 2 consecutive days. Rogel! of NIMH said participating in grams," he concluded. "It is an oppor­ "In addition," he continued, "plans the festival is just another factor that tunity for all scientists on the NIH cam­ for the workshops, posters, and sym­ helped him define his future in medi­ pus to become reacquainted with ongo­ posia came directly from the inter-insti­ cine. "I plan on entering medical ing research in areas related to and dis­ rute research interest groups, which school next year," he said, "and I came tant from their own work. Perhaps, assured the highest quality in the scien­ to NIH to work in the lab and get some most importantly, it is a reminder that tific presentations at the Research experience in research. There's a great with all its problems and frustrations. Festival. The interest groups, and in diversity of information here and I' ve the NTH campus provides a research particular the interest group chairpeo­ enjoyed the experience. Now I defi­ environment that is most conducive to ple, were extremely cooperative and ni tely want to add some component of the unfettered pursuit of new scientific helpful , and were the principal reason research to my career as a doctor." knowledge." that this year's festival was successful." The fomrnt may evolve and the loca­ The 1996 Research Festi val is sched­ Two scientific symposia, 28 work­ tion may migrate, but for first-year pre­ uled for the week of Sept. 16-20 and shops. more than 300 posters in four senters and veterans alike, the Research will be organized by the National sessions, a picnic and a scientific Festival is a welcome constant, accord­ Instirute of Dental Research. A NIDR equipment show by the Technical Sales ing to Baney. Distinguished Alumni Symposium is Association constituted the 1995 festi­ "The NIH Research Festival is an planned. Details about the program val, which kicked off with a 2-day open annual opportuniry to showcase the will be in the next issue of NTHAA house featuring guided tours of the breadth and depth of scientific exper­ Update.

4 SPRING 1 9 9 6

Calendar of Exhibits and Upcoming Events

SPRING Jr.. Museum of Medical Research in Thursday, June 20 with a program on collaboration with NCHGR. NlAlD, "Fifty Years of Peer Review." It will "Death and Disease in the NCJ, NHLBI. and NlGMS will be dis­ be held at the William H. Natcher Neighborhood: Medical Maps of played in June. The show wi ll be in the Conference Center from 8:30 a.m. to 5 Washington. D.C., 1878-1909." is a new Clinical Center on the first noor near p.m. A reception will follow. For exhibit on display until the end of April the Dental Clinic. more infom1ation call (30 I) 435-0691. in lhc front lobby of NLM (Bldg. 38. In conjunction with the exhibit, on Also on Thursday, June 20. the 8600 Rockville Pike). The exhibit Sarurday, June 8, there will be an all­ General Motors Cancer Foundation traces the evolution and publication of day symposium, "Revolution in Laureate Lectures will be held in Masur epidemiological maps of the U.S. capitol Progress," co-sponsored by the Auditorium, Bldg. I 0, from 2 to 4 p.m. city until 1909, when the public health Smithsonian Re ident Associates lntroduction by Dr. Joseph G. Fonner. officer ofthe District of Columbia dis­ Program and the DeWitt Stetten, Jr., president. GM Cancer Research continued their use in his annual report Museum of Medical Research. Contact Foundat ion. The lectures are by win­ to the city commissioners. This show Smithsonian Resident Associates pro­ ners ofGM's Sloan. Kettering. and will be followed by one highlighting gram (202) 357-3030 for information Mott Prizes for Cancer Research. acquisitions from the Collection of the about cost. Dr. Victoria A. Harden, History of Medicine Division. For more Steuen Museum director, will chair the There is a series at NIH called the information call (30 I) 496-5405. symposium. Speakers and their topics Wednesday Afternoon Lectures, held at will be the fo llowing: 3 p.m. in Masur Auditorium, Bldg. I 0. ·'Mapping our Genes," Dr. Robert For more information call Hilda MAY Nussbaum. chief. Laboratory of Madine at (30 I) 594-5595. Genetic Disease Research. NCHGR; For more information about various On Saturday, May 18. a second NLH ·'Genes Aren't Necessarily Destiny:· lectures and events at NIH. call (30 I) Community Forum is scheduled for the Dr. Peter Greenwald, director, Division 496-1766. For more information about William H. Natcher Conference Center. of Cancer Prevention and Control. NCI; NlHAA call (301) 530-0567. For more infonnation call Barbarn "Gene Therapy: lts Challenges and McDonald, Office of Community Promise." Dr. Cynthia E. Dunbar, Liaison at (30 I) 496-393 1 or 402-25 19. senior clinical investigaror in the ****** Hematology Branch, NHLB I; Coming up in the Fall "Treating Pa6ents with Genetic JUNE Diseases:· Dr. Harry Malech, deputy SEPTEMBER chief. Laboratory of Host Defenses, The NIH Director's Cultural Lecture NlAID:and Research Festival '96 will be on Thursday, June 6 at 3 p.m. in ·'Ethics and Genes." Dr. Robert Sept. I6 and 17 - Symposia. Poster Masur Auditorium. Bldg. 10. The Murray, professor of pediatric medicine Sessions. Workshops in William H. speaker is Dr. Murray Gell-Mann. pro­ and ethics. Howard University School Natcher Conference Center. fessor and co-chairman of Science of Medicine. Sept. 19 and 20 - Technical Sales Board. Santa Fe Institute and Roben Association Scientific Equipment Show The annual meeLing of NTHAA will Andrews Millikan professor emeritus in tents ou1 side the Clinical Center. be Saturday, June 15 al the Mary of theoretical physics, California Insti­ Woodard Lasker Center (the Cloister). tute ofTechnology. The title of his talk For more information call (30 I) 496­ Bldg. 60, on the grounds of the N 11-1 is "From Simplicity to Complexity." 1776 or e-mail: [email protected]. campus. Invitations with details will be mailed to NlHAA members in May. "Revolution in Progress: Human OCTOBER Genetics and Medical Research." an The Division of Research Grants exhibit prepared by the DeWin Stetten. will celebrate its 50th anniversary on The first James A. Shannon Lecture.

5 N I H A A U P D A T E

News From and About NIHAA Members and Foreign Chapters

Dr. Habeeb Bacchus, who was wi th L988, lastly as chief, Laboratory of Dr. Bruce Chabner, with NCIfor 23 the NCI Metabolism Service from L957 Immunobiology, received in 1987 the years, lastly as director of the Division to 1959, writes, "I retired from my Senior U.S. Scientist Award from the of Cancer Treatment, is now chief of position as chief of medicine and chief Alexander von Humboldt Foundati on the clivision of hematology and oncolo­ of endocrinology and metabolism at of the Federal Republic of Germany. gy and director of the clinical cancer Riverside General Hospital in Califor­ The award included time for research at center at Massachusetts General nia. I retain my position as professor of the University of Mainz. Borsos reports Hospital. He has recently joined the medicine. Loma Linda Universiry that be also "was honored at a 3-day scientific advisory board at ONCORx, School of Mecli cine. ln the latter Festschrift on 'Structure-Functi on inc. based in New Haven, Ct. capacity, I was visiting professor of Relationship of C.l Q and Collecti ons, medicine at SiJ Run Run Shaw Hospital C l Esterases: C ir, C ls, and Cl in Hangzhou, China. This hospital is Inhibitor in Health and Diseases'." Dr. Barry S. Coller, who was in the affiliated wi th the Zhejiang Medical hematology service in the CC's pathol­ Uni versity. The residency training pro­ ogy department from July 1972 to June grams in internal medicine, surgery and Dr. Stefan Bracha, a fellow in the 1976, is now direcror and chiefof med­ emergency medicine are conducted Neuropsychiarry Branch, NlMH, from icine at Mr. Sinai Hospira!, New York. under a contract with Loma Linda L983 to J 985, bas moved to H onoJulu, Recently he was elected vice president Uni versity Medical Center. I spent six Hawaii from the Little Rock Veteran's of the American Society of Hematol­ weeks at SRRS hospital in Hangzhou Administration Medical Center and the ogy, Washington D.C., during its annu­ earlier this year ( 1995) and plan to Univers.ity of Arkansas ChiJdJen's al meeting in Seattle. The group has return for another six weeks in 1996 to Hospital. He wri tes, "l have been about 7 .000 members from over 50 present lectures on internal medicine appointed associate director for countries. (emphasis endocrinology-diabetes) and researcb at the Pacific Cenrer for Post­ conduct teaching rounds." Traumatic Stress Disorders as well as clinical professor of psychiatry at the Dr. George J . Cosmides retired on University of Hawaii. Twas also Apr. I, 1995, as associate director for Dr. David A. Blake, a research associ­ appointed chief psychiatrist for World NLM's Speciali zed Informati on ate in the Pharmacology-Toxicology Health Organization field psychiatric Services, where he had worked since Program (N lGMS) in the Laboratory of behavioral disorders and adult attention Chemical Pharmacology, NHLBI, wi th deficit disorders." Dr. F. R. Gillett e from 1966 to 1967, wi ll leave his position as executive vice dean and vice dean for research at Dr. Paul Bunn, Jr., a section head in Johns Hopkins Uni versity School of NCJ's Division of Cancer Treatment Medicine on July 1. He will join the from 1973 to 1984, is now director of Association of American Medical the Uni versity of Co.lorado Cancer Colleges as senior vice president for Center in Denver. He is president of research to head AAMC's efforts to rJ1e Association of American Cancer bolster research at the nation's medical institutes for 1995-96. Newly elected schools and teaching hospitals. He also AACI board members include the fol­ will evaluate job opportunities for the lowing NII-I AA members: Richard biomedical-Ph.D. communi ty. Schilsky, Uni versity of Chicago 1974. Prior to that he worked as direc­ Cancer Research Center; Robert tor of the Phannacology-Toxkology Young, Fox Chase Cancer Cenrer; and Program at NIGMS since 1963. He I. Bernard Weinstein, Columbia­ had started at NIH as a senior scientist Dr. Tibor Borsos. at NCI from 1962­ Presbyterian Cancer Center. (psychopharmacologist) at the psy­

6 SPRING 1 9 9 6

chopharmacology service center, choline at the neuromuscular junction, years and is widely renowned for his N1MH, from 1959 to 1963. He writes. Fischbach is a past president of the work on HI V and AJDS. "I enjoy reading the newsletter very Society for Neuroscience. much and I look forward to actively participating in the activities of Dr. Joseph L. Goldstein, Nobel NIH AA.'' Dr. William T. Friedewald, who was laureate and chainnan of molecular at NIH from 1965 to 1989 in NIAID, genetics at the University of Texas NHLBI, and OD/N IH associate director Southwestern Medical Cenrer. Dallas, Dr. Rita Colwell, a member of a for prevention, is now senior vice presi­ has been chosen chainnan of Lhe Alben micro-biology Iraining committee al dent and chief medical director ai Lasker Medical Research Awards jury. NIGMS from 1970 until 1973 , as well Metropolitan Life in New York. He is He won the 1985 Lasker Award in as other NIH advisory councils, is now a member of the NIH director's panel Basic Research and the 1985 Nobel president or the Maryland on clinical research. Prize in Physiology or Medicine (with Biotechnology Institute at the Michael S. Brown). Uni versity of Maryland. As president of the American Association for the Dr. Robert Gallo, who retired from Advancement of Science, she delivered NCI as chief of the tumor cell biology Dr. I. David Goldman, who was in the President's Lecture at the 1996 laboratory. has been named director of NCr s Laboratory of Chemical annual meeting and science innovation the Institute for Human Virology, Phannacology from 1966 to 1969. has exposition in February 1996. She which will be housed within the left as director of the Massey Cancer addressed the issue of global environ­ Uni versity of Maryland system in Center at Virginia Commonwealth mental chunge and its influence on the Baltimore. Gallo worked at NIH for 30 Comi11 11ed on p. 8 emergence of infectious disease. Colwell's lecture, "Global Change: Emerging Diseases and New Epi­ demics," examined how changes in cli­ mate impact and enhance the develop­ ment and spread of newly emerging diseases.

Dr. David A. DeBoer, who was at NHLB I from 1987 to 1989, writes, "J have completed my fellowship in car­ diothoracic surgery and have entered private practi ce with a group in the nonhem suburbs of Chicago.'·

Dr. Gerald D. Fischbach, who was in the Laboratory of Neurophysiology from 1966 10 1973, is now Nathan March Pusey professor of neurobiology and chairman, department of neurobiol­ ogy, Harvard Medical School. He has been appointed to the advisory panel of This NCI group, composed mostly of alumni {some are still gainfully employed), meets for the National Institute of Neurological lunch throughout the year on an irregular and irreverent basis. Members of the group are Disorders and Stroke. An expen on the (bottom row, from I) Bill Walter, Bud Morrison and Phil Waakles and (top row, from I) Jack function of the neurotransmitter acetyl­ Kalberer, Cal Baldwin, and Carl Baker.

7 N I H A A U P D A T E

Continued from p. 7 Dr. Jack D. Keene, a staff fellow in University to become director of the the Laboratory of Molecular Genetics Albert Einstein Cancer Center, an affil­ at NINCDS from 1974 to 1978, is pro­ iate of Montefiore Medical Center. fessor and chairman. department of microbiology at Duke University Medical Center. He is also co-chair­ Dr. William J. Goodwin, at NCRR as man of the Diversity Biotechnology director of the Primate Research Cen­ Consortium in Santa Fe. New Mexico, ters Program from 1963 to 1975, reports, chairman of the molecular biology "Jn May l995 I retired as associate sci­ study section at NTH and a member of entific director from the Southwest the Pew Scholars national selection and Foundation for Biomedical Research in advisory board. San Antonio, Texas. l moved to Port­ land, Oregon and have organized a con­ sulting organization known as Senior Dr. Henry Kingdon reports, "After I Biomedical Research Consultants." was a clinical associate at the Hean Institute (Laboratory of Biochemistry with Earl Stadtman), I went to the Dr. Alan I. Greenfield, a clinical fel­ Dr. R onald B. Herberman, at NCI University of Chicago. 1967-73. and low in NCI's Division of Cancer from l 966 to 1985. was honored by the University of North Carolina, Treatment from 1970 to 1972, writes, Pittsburgh business and community Chapel Hill from 1973 to 1981. I 'Tm currently chief of cardjovascular leaders in February as man of the year joined Baxter Healthcare in 1981 and and interventional radiology at New in science and medicine. Vectors/Pitts­ currently am vice president. Clinical England Medical Center in Boston, burgh. a volunteer organization of and Regulatory Affairs, Gene Therapy specializing in the management of end­ young professionals. presented the Unit at Baxter." stage portal hypertension, and professor award to hjm on Feb. 3. Recently, he of radiology at Tufts University School was named associate vice chancellor of Medicine." for research at the university's health Dr. Lloyd Law writes,·· I retired as science center. Herberman, who was chief, Laboratory of CelJ Biology at the founding director of the l 0-year-old NCl in December 1990 and am now Ophelia Harding, who recently retired University of Pittsburgh Cancer scientist emeritus in the Laboratory of after 40 years of service with NIH, last­ Institute, which he will continue to Genetics in Bldg. 37. Recently, I was ly as housing manager for the Division head. also became Hillman professor of elected an honorary member in the of Space and Facility Management, OD, oncology at Pitt in 1993. American Association for Cancer has moved out of the NIH apartment Research and the European Association house at 20 Center Drive to Grosvenor for Cancer Research. I am now in a Lane apartments in Rockville. Dr. Suza nne T. lldstad, who was at position to help you in the association." NCI from 1982 to 1985, is now at the University of Pirtsburgh. She and her Dr. Edward Henderson, at NCI in the colleagues designed the treatment that Dr. Michael J. Leibowitz, fonne rly a Division of Cancer Treatment from AIDS patient Jeff Getty received in the postdoctoral fellow in the Laboratory 1961 to 1973, is now a medical officer baboon bone marrow transplant. They of Dr. Reed Wickner (Laboratory of at the FDA. He was recently named to added special facilitator cells to baboon Biochemical Pharmacology, NlAMDD, the nationa1 board of trustees of the bone marrow stem cells in hopes ir from 1974 to 1977), is currently a pro­ Leukemia Socie ty of America. This would help the cells engraft into fessor of molecular genetics and micro­ honor was announced at the society's Getty's system and begin producing biology at UMDNJ-Robert Wood annual leadership conference held in disease-fighting baboon immune sys­ Johnson Medical School, where he is Pittsburgh. tem cells. also associate dean of the Graduate

8 SPRING 1 9 9 6

School of Biomedical Sciences. His Laboratory of Biochemical Generics, now chair of the National Cancer research interests include continui ng NHLBI, from 1975 to 1977 and a mem­ Advisory Board, a presidentially studies on the molecular genetics of ber of NEI from 1980 to 1985, was appointed group that serves as council killer virus of yeast, which began while recently named a Research to Prevent for NCI. She also is director he was at NIH . Blindness Senior Scientific of cancer prevention. detection and lnvestigaror. He is currently a profes­ control research at the Duke sor of ophthalmology and physiology at Comprehensive Cancer Center and pro­ Dr. Roger P. Maickel, who was a sec­ the University of Michigan. He writes, fessor and senior fellow ar the Center tion head in the Laboratory of "I enjoy the newsletter." for Health Po li cy Research and Chemical Pharmacology, National Education, Duke Uni versity Medical Heart Institute, from JuJ y 1955 to Center. May 1965. reports, "I am presently Dr. Barbara Rimer, who was at Continued 011 p. JO ·wearing two hats.· In addition to my NlH from 1974-76 in NCl's lJCPC, is academic post as professor of pharma­ cology and toxicology in the School of Pharmacy and Pharmacal Sciences at Purdue, I also serve half-time as direc­ tor of the University Laboratory Animal Program under the vice-presi­ dent for research."

Dr. Seymour Perry, a member of the NlHAA board of directors who was at NCI from 1961 to 1974 and then in the OD/NIH (first as a special assistant before becoming an associate director in 1978). where in 1977 he was instru­ mental in the initiation of the NTH Consensus Development program and its first director, has a new title. He was recen tl y named director of a newly designated WHO Collaborating Center for Health Technology Assessment at the Medical Technology and Practice Pattern Institute, a nonprofit heahh pol­ At a well-attended meeting on Thursday, Oct. 12, 1995, Dr. John F. Sherman, chairman of icy research group in Washjngton, D.C. the awards committee, presents to Dr. Maxine F. Singer the 1995 NIHAA Public Service The mission of the center is to work Award , an etched desk plaque depicting the Shannon building. The accompanying citation wi th nati onal and internati onal organi­ states, "The National Institutes of Health Alumni Association 1995 Public Service Award zations and individuals. especiall y in presented to Maxine F. Singer, Ph.D. in recognition of her individual accomplishments as a developing countries, on "all aspects of distinguished scientist; her effective advocacy of the optimum role of science In society; and the development, evaluation and use of the sensitivity to the effect on society of emergent issues in science. She has brought these essenti al technologies for health." qualities to bear at critical times In the march of science helping greatly in bringing public understanding and acceptance of the use of beneficial new and powerful techniques such as recombinant DNA. Now she Is launching a movement to stimulate an early interest in sci· ence on the part of ail children . For more than three decades Maxine Singer was at the Dr. Donald Puro, an NTGMS Pharma­ forefront of intramural science at NIH. She has continued as an NIH scientist emeritus since cology Research Associate in the 1988 while serving the Carnegie Institution of Washington as its president. Her many hon­ ors include the Nation's highest scientific award , the National Medal of Science ."

9 N I H A A U P D A T E

Co11ri1111ed from p. 9 support. The progress and future of Dr. Donald B. Tower, former director research depends on NIH. Keep up the of the National Institute of great work!" Neurological Disorders and Stroke from 1973 to 1981, has moved with his wife from tJ1eir home of 35 years in Dr. Lawrence E. Shulman, NIH emis­ Chevy Chase to Asbury Methodist sary for clinical research to the academ­ Village villas in Gaithersburg. ic health centers, and director emeritus of NTAMS, was the recipient of the Gold Medal A ward from the American Drs. P. Roy Vagelos, NIHAA 1994 College of Rheumatology (ACR) at its Public Service A ward winner, and recent national meeting in San Vincent T. De Vita, Jr., fom1er NCI Francisco. The Gold Medal, the high­ director, both received the Durham, est award the ACR bestows, was given N.C. 1995 City of Medicine A wards to Shulman "in recognition of his major last October. The City of Medicine contributions to rheumatology in the A wards were established in 1988 to United States." He is an expert in the honor those whose discoveries or research and treatment of lupus, and developments serve the public interest. discoverer of eosinophilic fascitis, also The award includes an honorarium and Dr. J ohn C. Ruckdeschel, a staff asso­ known as Shulman's disease. a Baccarat sculpture. ciate at NCI from 1972 to 1975, and a visiting scientist 1983-84 at the NCI­ Navy Medical Oncology Branch, is Dr. Gordon Wallace, who was associ­ now director of the 1-1 . Lee Moffitt ate director for intramural research, Cancer Center and Research Institute, NIAID, 1960-86, and former NlHAA University of South Florida, Tampa. He president from 1990-1991, reports that was recently appointed by Florida Gov. Bio-Brite, Inc., the company he found­ Lawton Chiles as chair of the Florida ed in 1989, continues to grow. cancer control and research advisory "Revenues tripled in 1994 and doubled committee, which advises state govern­ in 1995. The company whose mono is ment on cancer-related issues and pro­ 'light for health,' was founded as a motes cancer control programs. technology transfer activity with N!MH to develop a portable light dosage sys­ tem for the treatment of seasonal affec­ Dr. Paul Shapshak, a staff fellow at tive disorder. Bio-Brite's products NlCHD, 1974-1976, writes, "I am include the Light Visor, the SunRise happy to report that since I was at NIH, Alarm Clock-a dawn simulator that 20 years ago, l have reached fu ll pro­ has been featured in several major cata­ fessor in three departments, psychiatry, logues, and a Jet Lag Kit" neurology, and pathology. My research is supported by NIDA, NJMH, and Dr. Samuel O. Thier, clinical associ­ NINOS and focuses on drug abuse and ate, NIAMD, 1962-64. nnd now presi­ Dr. Catharine Wingate, who retired AIDS. ram doing research on the fol­ dent of the Massachusens General recently as scientific review administra­ lowing topics: inactivation of HIV, Hospital and professor of medicine at tor of the diagnostic radiology study HIV sequence molecular epidemiology. Harvard Medical school, received the section, Referral and Review Branch, and determining mechanisms of neu­ 1995 Distinguished Alumnus award Division of Research Grants, after 17 ropathogenesis. I wish to communjcate from the SUNY Health Science Center years of federal service, plans to con­ to colleagues and staff how lucky I am in Syracuse, N.Y. He graduated from sult and perhaps teach. Other retire­ to have been at NIH and to receive NTH the Upstate Medical Center in 1960.

10 SPRING 1 9 9 6

menL pursuits will include sailing and gardening. AMessage from the NIHAA President

By Calvin B. Baldwin, Jr. You will read in this issue of Updare Dr. H. Rodney Withers, who is pro­ Lhat NIH continues to receive favored fessor and chair of the department of Jexpect that most of our membership treatment from Congress with a 5.7 radiation oncology at the UCLA School would agree with me that our most im­ percent increase in FY 1996, a year in of Medicine portant activity is publishing our news­ which many federal agencies are being and the letter, the NJHAA Update. Because it cut. Much of the credit for the NIH Jonsson is no longer possible for alumni to sub­ budget increase goes to Rep. John Compre­ scribe to the NIH Record, the Update Porter, current chairman of the House hensive becomes our main source of informa­ Appropriations subcommittee, that is Cancer tion about past, present and future NIH responsible for the NIH budget. Our Center, was activities, including news about NIH past president, Tom Kennedy, testified recently staff and alumni. Our goal is to publish as a citizen witness, recommending an awarded the the Updare at least three times a year. increase in the NTH budgetfor 1996. International However, budget considerations have We are preparing testimony to be pre­ Association limited publication to twice a year for sented to the House and Senate for the for Radiation Research (!ARR) Gray the past two years. To reduce the ex­ FY 1997 NfH budget. Medal, one of the most prestigious pense, this issue of the Updare is being Finally, let me highlight four other awards in the field of radiation printed on less expensive paper. We activities of the NTH AA: research. Withers was interim director are initiating an effort to increase our • The board voted in favor of of the UCLA Cancer Center last year. membership by inviting former NIH preparing a membership directory of He also presented the Seventh Gray advisory committee members to join paid-up NIHAA members for distribu­ Lecture at the Congress of the !ARR in NlHAA. Members of the Montgomery tion to the membership. We hope it Germany last August. The County Chamber of Commerce also will be ready for distribution at our lmemcuional Commission ofRadiation will be solicited to join the association ann ual meeting. Units and Measurements News recently as "friends." A larger membership wi ll • The NTH AA was awarded a con­ called Withers "a scholar and teacher of enable us to publish the Update more tract by NIH to identify, label and pro­ the highest distinction." It added that often. Also please renew if you have 1ect objects of historic importance to the in the world of transnational research not done so (look ac your mailing label NI H. Many of our members are work­ between radiation biology and radiation to see if you are up-to-date) and pay ing with the institutes on this projecl. oncology, "he stands as perhaps the promptly when your 1996-1997 renew­ • Dr. Gordon Wallace, NLHAA 's most preeminent role model in the al notice arrives in May. first president. is again act ive as chair­ world today." Our annual meeting is scheduled for man of the science education support June 15, 1996. We will honor Mrs. committee. This committee is assisting Florence Mahoney as the fourth recipi­ NIH fellows and associates with six Dr. John W. Yarbro, who was at NCI ent of tl1e N[HAA Public Service seminars on "New Careers for Young from 1972 to 1975 as director of the Award. Please put that date on your Scientists." cancer centers program, has been re­ calendar. President Harry Truman once • The board has approved the pro­ elected chair of the United States described Florence Mahoney and Mary posal of the science policy forum com­ Pharmacopeial Panel on Hematologic Lasker as ''the most tireless, consistent, miuee to sponsor an annual James A. and Neoplastic Diseases and elected and effective crusaders [for biomedical Shannon lecture. The first lecture is vice-chairman of the American Joint researchl that I had ever known." We scheduled for Fall 1996. Committee on Cancer. He is also edi­ are working on a program that we hope Please note that it is once again tor of Seminars in Oncology and pro­ will match our very successful annual time Lo elect new NIHAA board mem­ fessor emeritus at the University of meeting last year at which Rep. Connie bers. You will find your ballot on p. 29 Missouri. Morella, Bob Butler and Wendy ol' this issue. Please vote! Baldwin spoke.

11 N I H A A UPDATE

Memorial Events Honor Anfinsen and Stetten In Israel At NIH Association. The first Anfinsen lecture Drs. Sara Fuchs and Yadin Dudai was delivered by Dr. Ira Pastan in On Apr. 22, 1996, a memorial ser­ reported the following from Israel: November 1993 on the occasion of the vice to celebrate the Li fe and work of "On Nov. 16, 1995, the Israe li chapter establishment of the Israeli chapter of Dr. Christian B. Anfinsen was held in of tbe NIH Alumni Association held its the Nlli Alumni Association, in Wilson Hall. The service was foUowed second meeting on the grounds of the Rehovot. Following the death of by an International Conference on Weizmann Institute of Science, Anfinsen on May 14, 1995, the lecture Protein Folding and Design, held Apr. Rehovot. About 250 alumni participat­ series was renamed 'The Christian B. 23-26 at the William H. Natcher ed. The main event was the First Anfi nsen Memorial Lecture.' On Nov. Center, also in Anfinsen's honor. Christian B. Anfinsen Memori al 16, 1995, during the annual meeting of Dr. AJan N. Schechter, chief of the Lecture, delivered by Dr. Harold E. the board of governors of the Laboratory of Chemical Biology, Yarmus, NIH director and Nobel laure­ Weizmann Institute, another event was NIDDK, organized the service. ate. Yarmus spoke on 'Genes, Mice, held to commemorate Chris: Schechter, Anfi nsen 's successor as and Cancer.' He was introduced by Inauguration of the Christian B. laborarory chief, wrote the following Prof. Michael Sela, a former student Anfinsen Garden at the Weizmann tribute in the preface to the conference and close friend of Chris's. The series Institute campus. Many of Chris's stu­ program: was established in 1992 by Anfinsen's denrs and friends, as well as his wife, former students with the help of tl1e attended both the memorial lecture and "Chris Anfinsen's deatl1 ended a Foundation for Advanced Education in the inauguration of the Anfinsen half-century scientific odyssey that the Sciences and tl1 e NIH Alumni Garden." encompasses much of the birth and maturation of protein chemistry as we know it roday. After his move to 1he NIH in l 950, he focused his bio­ chemical studies on understanding the chemical structure ofenzymes with the Long-term goal of being able to synthesize proteins. "He immediately recognized the gen­ eral significance of his early protein refolding experiments done during this work, because he always saw resLLlts in the context of the whole picture, with mi.nimal intellectual baggage from then current theories or experimental minuti­ ae. This perspective enabled him to fom1ulate the thermodynamic hypothe­ sis of protein fold ing, which still sup­ plies much of the paradigm for tl1e field ... It also fueled the courage that allowed him, in his work with many inrernational organizati ons, to help change the world for the bener. We conti nue in many endeavors under the The memorial tablet in place at the Christian B. Anfin sen Garden Inauguration on Nov. 16, compass headings he defined." 1995, at th eWeizmann Institute campus in Rehovot, Israel

12 SPRING 1 9 9 6

Sletten Memorial Cruise

"Medicine Now and in the 21st Century," was the theme of a fundrais­ ing study cruise held Feb. 17-24, 1996, to the Eastern Caribbean aboard the MS Westerdam. Proceeds wiU benefit the DeWitt Stetten, Jr., Memorial Fellow­ ship in the History ofTwentieth­ Century Biomedical Sciences and Technology. Sponsored by the Friends of the Stetten Museum, which is coordinated The speakers in the " Medicine Now and in the 21st Century" gather for a group portrait by Jane Lazarow Stetten, and also by before disembarking. They are (from I) Dr. Peter Greenwald, Jane Sletten, Dr. William the University of South Florida College Sanslone, Dr. C. Everett Koop, Dr. Robert Butler, Dr. Seymour Kety, and Dr. Victoria Harden . of Medicine, the cruise featured lec­ tures by speakers distinguished in med­ l nstitute at Dartmouth was exploring adopted individuals. he discussed icine, medical research, and the eco­ ways to improve post-graduace medical genetic factors chat contribute to the nomics of medical care. education and how a new venture he development ofschizophrenia and Dr. Victoria A. Harden, NIH histori­ has launched with Time-Life-Warner other mental disorders. an and director of the DeWitt Stetten, will provide patients with videos to help In speaking about "Genes and Jr., Museum of Medical Research. pro them understand their disease and formu­ Cancer:· Dr. Peter Greenwald, director vided an historical background for the late meaningful questions in preparation of NCr's Division of Cancer Prevention museum and fellowship. The fellow­ for their next physician visic. He also and Control. noted that although genes ship supports a year in residence at the noted his advocacy for a "Shape Up, may affect cancer risk. there is a com­ Stetten Museum for a pre- or postdoc­ America!" program that urges Ameri­ plex interaction between genes, toral fellow. Harden described the cans co lose weight and get some regu­ lifestyle and environmenL He empha­ importance and noticeable lack of lar exercise in order to stay healthier. sized that lifestyle is of major impor­ research documenting the numerous Dr. Seymour S. Kety, Fonner scien­ tance to the prevention of cancer: contributions of biomedical research ti.fic director of N1MH, presented tobacco use, diet and alcohol abuse are toward improving human health during "Genes and Mental Functi on." among the most important factors asso­ the twentieth cenrury. Drawing on studies of family trees ciated wirh cancer development. The keynote speaker was former (pedigrees), concordanr illness rates in Greenwald also showed some examples Surgeon General C. Everett Koop, who twins, and similar comparisons in Co111in11ed 011 p. 14 described the sweeping changes and the challenges in health care. He identified Among the America's incompatible demands NlHAA group between health care needs and technol­ enjoying the cruise are ogy and health financing reform. He (from I) emphasized the need for the President Harriet to appoint a Surgeon General who can Greenwald, speak out as "America's doctor." Koop Jane Sletten, reviewed current stresses on the doctor­ Wilho patient relationship in HMOs. the need Tommila, to refonn post-graduate medical educa­ Mary Calley tion to take advantage of the communi­ Hartman, Cal cations revolution, and the need to Baldwin, and emphasize prevention in health care. Betty He discussed how the C. Everett Koop Baldwin.

13 N I H A A UPDATE

Co111i11ued from p. 13 Attention of how modem biology is being used to NIHAA wantsto hear from its members . Please type or print your note for a future design new foods, which could have a issue and mail it to Update at 9101 Old Georgetown Rd ., Bethesda , Md 20814-1616 secondary effect on world health and future disease risk. Name Dr. P. Roy Vagelos used examples from M erck & Co. to show how the Home Phone pharmaceutical industry can build upon Home address knowledge of speci fic enzymes in criti­ cal biochemical pathways to make drugs effective against coronary heart News, including dates/position at NIH and photo if po ssible disease, benign prostatic enlargement. river blindness,

NIDDK, Pima Indians Celebrate 30 Years of Cooperation By Jane DeM011y

When I I-year-old Christopher Johns crossed the finish line at Sacaton. Arizona's HuHuKam Memorial Hospital, he was a winner twice over. As a first-place finisher in one of sever­ al 3.5-mile races that highli ghted the celebration of "30 Years of Cooperation for Better Health" between the Pima Indians and NIDDK researchers. he carried home a T-shirt and a ribbon. By exercising hard, Christopher and a hun­ dred other runners also were claiming continued health for their own bodies. Nearly 1,000 members of the Gila River Indian Community marked the anniversary with open house tours of the NIH Clinic, balloons and races. good food. good music and a spirit of gratitude shared by NIH scientists and Pima volunteers. Members of the tribe's Youth Council painted children's faces while Dr. Peter Bennett, chief of the Phoenix Epidemiology and Clinical Research Branch of NIDDK, "Three Feathers," a Pima-Papago band, acknowledges the vital work done by Pima recruiter Rechanda Allison at the celebration. not only played country music but also music for the "chicken scratch," a pop­ and transport volunteers to the clinic, The Pima, Zuni. and Navaho tribes will ular dance that is a part of many Pima and honored retired recruiters Bertha participate in the OPP. celebrations. The 1995 festival-goers Evans and Rechanda Allison with cor­ The multicenter study will recruit took home a memorial poster by Pima sages and hugs. 4,000 volunteers, and stress Lifestyle artist Michael Chiago, featuring an ear­ Gov. Mary Thomas expressed thanks changes such as choosing a high-fiber, lier generation of Pima basket dancers. to Bennett and NIH scientists for low-fat diet and regular exercise to ln a mid-morning ceremony, Dr. research that will help prevent diabetes maintain healthy weight. Eighty per­ Peter Bennett, chief of the Phoenix in Pima children now and in future gen­ cent ofpeople with diabetes are obese. Epidemiology and Clinical Research erations. Earl Laurence, deputy director The 6-year OPP wiU also test the use of Branch of NIDDK, voiced his thanks of NIDDK. presented the Secretary's oral medications to prevent the onset of for the crucial role Pima volunteers A ward for Distinguished Service to Dr. noninsulin-dependenr diabetes (NIDDM). continue to play in NIDDK diabetes Clifton Bogardus, chief of NIDDK's Volunteers must have impaired glucose and obesity research. He presented clinical diabetes and nutrition section. tolerance, a condition which often leads plaques expressing appreciation to "We need to think of the present and to NIDDM. Half the volunteers will be Mary Thomas, governor of the Gila the future as well as the past," Bennett minorities at high risk for diabetes. River Indian Community; to Yi said. "Significant advances are taking NTDDK began to work with Pima Johnson, director of HuHuKam place. and we're very optimistic." He volunteers and the Indian Health Memorial Hospital; and to Anna was speaking of the fu ll-scale Diabetes Service in the mid L960's. after a health Alben, director of the Phoenix Indian Prevention Program (OPP), beginning survey revealed an astonishing rate of Medical Center. Bennett noted the in 1996. following a successful I -year NIDDM in the tribe. Half ofPima important effort of those who recruit pilot study among the Pima Indians. Co111i1111ed 011 p. 16

15 N I H A A U P D A T E

Cominuedfrom p. 15 Other work among the Pima Indians among people with NIDDM. Before lnd.ians 35 and older have diabetes, and led to a new understanding of the this work, ESRD was thought to be pri­ they develop NIDDM much younger mechanisms of glycogen regulation and marily a complication of insulin-depen­ than other populations. NIDDK its role in insulin resistance. When glu­ dent diabetes. researchers wanted to know why. cose is not needed for immediate ener­ Now, says Bennett, hope for the The colJaboration bas provi.ded gy, it is converted to glycogen and future is high: Phoenix researchers are insights into the d.isease that would stored in skeletal muscle, but in people focused on deciphering the genetics of have been impossible without the long­ with insulin resistance and NIDDM, diabetes; preventing the disease term cooperation of thousands of Pima glycogen synthesis through this path­ through behavioral and pharmacologi­ Indians. These insights have improved way is reduced. cal interventions; and altering the medical knowledge and health care for Clinical practice has also changed course of diabetic complications. In people with diabetes around the world. because of NIDDK-Pima studies. Dr. their attempts to discover what makes "The Pima Indians are giving a great WjJJiam Knowler and colleagues estab­ native Americans so terribly suscepti­ gift to the world by volunteering for lished that high blood pressure predicts ble to diabetes, NIDDK researchers and research studies," said Bennen. "We the complications of diabetes. Lower­ the Pima Indians have changed the way are all in their debt." ing blood pressure may slow the onset diabetes and obesity are understood and NIDDK research established that the of complications and the progress of treated, well beyond the environs of Pima Indians had I 0 times the preva­ already existing kidney disease, one of Atizona's Gila River. lence of NIDDM found in Caucasian the most lethal complications of dia­ A publication detailing the study, populations, and developed a formal betes. Clinicians now understand the entitled "The Pima Indians­ definition of diabetes and diagnostic value of detecting hypertension in peo­ Pathfinders for Health" is available. 1t criteria now used by the World Health ple with diabetes and treating it early. is NIH Publication #95-3821 and may Organization. Dr. David Pettitt and colleagues, be obtained from the National Diabetes Longitudinal studies showed that studying pregnant diabetic Pima Information Clearinghouse (NDIC), obesity and high levels of insulin in the women, found that their children are at lnfonuation Way, Bethesda, MD blood were strong risk factors for dia­ higher risk for obesity and diabetes, 20892-3560. betes, and that this hyperinsulinemia apart from any genetic tendency a child resulted from insulin resistance, a hall­ may have inherited. When a fetus is mark ofNTDDM. overfed by high levels of glucose in the These studies have also iUustrated mother's blood, premature birth, birth that diabetes and obesity run in fami­ defects, toxemia, and other problems If you are not a life mem­ lies, developing from genetic, prenatal, may result. Pettitt's work has also and environmental influences. NIDDK made it clear that the effects of an ber, you wiJl receive a dues research has highlighted the genetic uncontrolled diabetic intrauterine envi­ notice from NlliAA in May. complexity and the physiology of obe­ ronment do not end at birth. A moth­ sity, and clarified bow metabolic rate er's high blood sugar can lead to abnor­ Dues are an important source contributes to unhealthy weight. mal glucose tolerance and diabetes in of our income and we need An important piece of current rhe next generation. research among the Pima Indians is the Because of this knowledge, every your continued support. Also search for genes that predispose indi­ pregnant woman is now routinely gjven check your address label. [fit viduals to obesity, insulin resistance a glucose tolerance test, so that high and diabetes. Identifying these genes blood sugar can be strictly controlled says "membership expired" would allow doctors to identify individ­ pri.or to her child's birth. please renew promptly or this uals at high risk for NrDDM. These NIDDK researchers documented individuals could then prevent or delay end-stage renal disease (ESRD) among wiJI be your last newsletter. the onset of diabetes by choosing a the Pima Indians, leading to a better low-fat diet and exercise, or medica­ understanding of the kidney disease of tions, if the DPP illustrates their benefit. diabetes and the prevalence ofESRD

16 SPRING 1 9 9 6

Science Research Sarcopenia Explored as New Player in Human Genome Pro ject Completes Updates Frailty Research Genetic Map of Mouse DNA Frailty is a critical national health Human Genome Project researchers problem. lt affects people's physical have completed a dense "genetic map'' Clue to Cell Death in Alzheimer's Seen performance and ability to live inde­ of the DNA of the laboratory mouse. Scientists invest igating the genes that pendently. Some 25 million older The lab mouse is one of the best­ regulate programmed cell death-the Americans are frail. Most are in their studied animals in genetics, and its normal process by which old or unwant­ eighties-the fastest growing segment genetic information is about 75 percent ed cells die on schedule so the body can of the population. Their care costs the similar to that of the human. The reshape developing tissues-have dis­ nation as much as $80 billion a year. pub I ication of the mouse linkage map covered a gene fragment that is nearly Researchers are looking closely at a in the Mar. 14 issue of the journal identical to a piece of one gene recently new clue to the puzzle of frai lty among Na111re, along with a separate linkage linked to Alzheimer's disease. The the elderly. The clue is sarcopenia, or map of the human genome, marks the finding, published Jan. 26 in Science by muscle atrophy in old age. Like Joss of completion of the Human Genome a group from NlAID. is the first direct bone (osteoporosis). loss of muscle can Project's large-scale genetic mapping evidence that disregulation of the natur­ lead to weakness, faJls. and a loss of effons. al process may play a critical role in the mobiliry. And, like osteoporosis. sar­ ··Dense genetic maps make possible development of Alzheimer's disease. copenia will assume a major role in the identification of genes for single­ "We were taken by surprise." said frailry research. The National Lns1itute gene disorders and the dissection of immunologist and senior author Dr. on Aging will spend an estimated S 1.5 [multi-gene] traits," said officials of the Luciano D' Adamio, chief of the T-cell million on sarcopenia-related research Narional Center for Human Genome and molecular biology unit in the projects in fiscal 1996. Research in an accompanying editorial. Laboratory of Cellular and Molecular To gain a better understanding, NIA According to NCHGR Director Francis Immunology. "Our work suggests how organized t11e first international work­ Coll ins, and Deputy Director Elke an inherited form of Alzheimer's dis­ shop on sarcopenia. Twenty-nine Jordan, '·... these two maps have already ease could arise from the uncomrolled abstracts were presented covering four changed the face of human and mouse and premature death of neurons." areas: epidemiological studies; func­ biology." It is the first objective piece of evi­ tional and metabolic consequences; ori­ The Human Genome Project effort to dence that some part of the program­ gins, causes and functional changes; map the mouse genome began five years med cell-deat:h pathway is involved in and possible interventions for treatment ago. The final map was constructed by Alzheimer's disease. Human popula­ of sarcopenia. The workshop proceed­ Eric Lander at the Whitehead Institute tion data had suggested this, but the ings and summary of the research rec­ for Biomedical Research and the current finding provides a mechanism ommendations have been published in Massachusens Institute of Technology, to explain previous observations. a special issue of the Journals of and colleagues. This map contains Alzheimer's disease (AD) affects Geromology: Biological and Medical 7 .377 markers scattered along the chro­ more than 4 million Americans. Famil­ Sciences (Vol. 50A). mosomes-I every 400,000 nucleotide ial or early-onset AD is an extremely Because sarcopenia research is in its bases on average. Although the mouse aggressive inherited form of the illness infancy, very little information is avail­ genome is about the same size as that that strikes people between 30 and 60. able. The workshop raised questions of the human. it is packaged in 20 chro­ It accounts for up to 20 percent of all about the potential consequences of mosome pairs in tead of23. The new cases of AD. It progresses faster than sarcopenia: Do the metabolic effects of map provides dense marker coverage of the more common sporadic, late-onset muscle loss mean accelerated bone all 20 chromosomes. A full spelling form of the disease, which generally Joss, less tolerance for temperature out of all the markers would require develops after age 65. Otherwise, how­ extremes, impaired glucose homeosta­ over 500 journal pages, the report says. ever, the two types of the illness are sis, and obesity? And what about the so the complete marker information is indistinguishable, characterized by neu­ interaction between muscle and bone? being made available on the Internet at ronal degeneration and the development Researchers are addressing these and the Whitehead Institute (hnp://www­ of plaques and tangles in the brain. many other questions. gcnome. wi.mit.edu).

17 N I H A A U P D A T E

F11rlough/S11o w (comi1111edfrom p. I) furlough drew to a close on Jan. 5, some 7,300 workers were on duty in emergency slots (versus 8,400 NIH'ers who were idled). Many parking lots were packed. and to all appearances the campus seemed to be business-as­ usual. But the impact of the layoff was felt particularly hard in some quarters, notably the Clinical Center. "No new pati ents were admitted to protocols during the furl ough and the snow emergency. Patient care for those already enrolled in protocols continued as normal, although wi th a reduced Snow damage to Bldg. 10 Included a collapsed canvas roof over th e main south entrance staff,'' said Dr. David Henderson, CC and the uprooting of a larg e umbrella on the nearby sundeck. deputy director for clinical care. "Staff pitched in to provide seamless service. "Patients were consolidated on unit snow stonn with little damage. We appreciate their exceptional efforts where possible. Staff took on extra Some 77 volunteers with all-wheel­ and extraordinary dedication." assignments and made the best of a bad drive vehicles ferried some 200 patients Nursing department members rotated situation. They demonstrated that the and employees between the CC and on and off furlough for the duration of team can pull t0gether, whether the cri­ home during the blizzard's worst. and both shutdowns and showed remark­ sis is a political one or a weather one ... 580 employees spent at least one night able dedication in efforts to be at work Accumulating snow brought down at the hospital. Admissions personnel during the snow emergency. "The the canopy at the CC library entrance fielded close to 1.000 phone calJs a nurses stayed focused on the priority of and heavy winds toppled one of the day, many from patients around the patient care," said Kathy Montgomery, gianr umbre llas on the sun deck, but coun try whose pending hospitaJ visits associate CC director for nursing. otherwise the building weathered the coincided with the blizzard.

Furlough, Blizzard Delay Grants Issuing, Processing

T he 3-weck federal furlough and due in February, March and beyond." one national advisory council meeting I -week bli zzard of 1996 had a major There were rwo regular application faced the same fate for the same reason. impact on NIH's extramural community deadlines during the furlough for which "There just isn't sufficient time 10 distrib­ 1hat employees. grantees and potential applications were actually delivered 10 ute materials to members in order to grantees nationwide will still be reeling can1pus by mail, Fedex, etc. . but staff ensure a fair review of applications;• well into spring. were not here to do any of the basic Grant said. Approximately 2,000 grant awards were receipt processing or entry of the infor­ There are many other consequences of no1 issued that ordinarily would have been mation in lhe NIH database. Staff will the furlough and lhe blizzard with respect made during the momhs of December and now have 10 work doubly hard 10 catch 10 the conduct of research contracts. January, according to Geoffrey Grant. up on these applications and others 1ha1 announcements of research interests that director of the Office of Policy for Extra­ had been in-house. They faced another were not issued, and meetings lhat were mural Research Administratfon in NJ H's deadline on Feb. I. one of the major I H canceled. Office of Extramural Research. "Those receipt deadlines of the year. "II will take 6 to 9 months 10 dig out awards," he explained, "both new and ln addition. some review meetings from this backlog of work lhat snowballed continuation support or highly meritorious were canceled. either because the meet­ during the furlough." Grant concluded. and important research. will now have to ing would have occurred during the fur­ "'We may be linished digging out from be made in the next month or so as staff lough period or because materials could the blizzard. but the real digging out hns deal with the additional awards that are not be sent out in sufficient time. Al least just begun."

18 SPR IN G 1 9 9 6

CC Update (conti1111edfrom p. 1) Major recommendations contained in che options team report include the fol­ lowing: • Develop a "clear and logical gov­ ernance structure" to draw on the expertise or leaders from outside orga­ nizations and reflect the interests of CC clients-the institutes of NJH. • Secure a clearly defined, separate budget for the CC. one that is as stable as the NIH budget as a whole. • Develop a strategic plan with clear and measurable objectives. • Establish the CC as a "reinven­ tion laboratory'' to explore options to enhance efficiency and effectiveness. especially concerning procurement, This model of how the new Cllnlcal Research Center might look was prepared by the win­ ning design team-Zimmer Gunsul Fra sca Partnership. It shows an H-shaped low-rise wing personnel management, and use of added on to the front of th e clinic portion of the hospital. Much must be accomplished operational savings. before su ch a vision Is ever realized. Tht: revi1::w was pan of Vice President Gore's Reinventing to participate in a design-concept com­ posed, and NIH approved, hiring a pri­ Government IT initiative, designed to petition to demonstrate creativity and vate-sector developer to oversee con­ find ways to lower costs and improve technical ability. The candidates· mod­ struction and identify funding sources lhe efficiency of government programs. els for the proposed facility were dis­ for this project. That's never been done Gallin distributed copies of the CC played in the Visitor Information at NTH before.,. reinvention plan and discussed the Cencer in December 1995. Boston Properties. lnc .. was selected options team recommendations during "We sought commentS on the designs last August to oversee the project. ·'We his annual address and awards ceremo­ from throughout the Clinical Center tell the developer what we want and ny on Feb. 29. and NlH," said Gallin, "and more than need in a facility and they will coordi­ An Oregon finn has already been 300 written comments were received nate all phases of design, construction, selected to design and spearhead plan­ from the NIH community. The selec­ and project management·· Gall in ning for the CC's new clinical research tion team, and the N1H family both explained. facility-a new wing that NIH would came to the same conclusion in choos­ Also working with the Zimmer l'ike to add to the northwest facade of ing the Oregon firm . They were select­ Gunsul Frasca Partnership will be Bldg. 10. Zimmer Gunsul Frasca ed based on flexibility of design, inte­ NBBJ, a Seattle architecture firm with Partnership is a 180-person architectur­ gration of the faci li ty with the campus specialists in planning health-care facil­ al, planning, and interior design firm landscape, and adaptability for the ities; Earl Walls Associates and based in Portland, with a diverse port­ future." McLellan and Copenhagen. Inc., folio of public and private projects in The finn's design team will devote a California firms with expertise in lab settings ranging from urban centers to year to determining exactly what CC planning; and Metcalf Tobey Davis of university and res1::arch campuses. users want and need in their new facili­ Reston, Va., which will provide local The selection committee is composed ty, added Gall in. ''Staff in all depart­ coordination. of representatives from NIH; Boston ments and at all levels will be exten­ A display on CC renewal plans Properties, the project's developer; and sively consulted." showing the model and several archi­ expertS from the government and the Innovati on of design will be only one tectural drawings is located in an area private sector. As part of the selecti on hallmark of the project, he noted. "The near the first floor patient admission process, six design teams were invited CC renewal steering committee pro- desk.

19

SPRING 1 9 9 6

Dorothea Dix pioneered improved ca re for the mentally ill, was instru· mental in estab· lishing 32 mod· ern hospitals for mental patients, and organized women nurses during the Civil War. Here, she teaches a stu· dent nurse how to care for a child .

Dr. Crawford long was the first to adminis­ ter anesthesia to a patient undergoing surgery. He gave ether to a patient in Georgia in 1842. Here, an anesthetized patient has his pulse checked.

Major Walter Reed discovered that a mos­ quito was the vector of yellow fever in the Panama Canal Zone. He headed an Army Wilhelm Konrad Roentgen announced his board sent to Cuba in 1900 to study yellow discovery of the x-ray to the scientific fever. Their findings made possible con­ world in 1896. Here, a patient is x-rayed. tinuation of work on the canal.

21 N I H A A U P D A T E

NIH Notes from August received the PHS Commendation Medal elected a fellow of the American Statistical 1995 to March 1996 and certificate of the Commissioned Corps. Association, a distinction achieved by less The citation read. ·' ... for pioneering research than 5 percent of the membership. She was in the molecular biological aspects of cited for her "influential contributions and AWARDS AND HONORS autoimmune disease" ... Or. Gunther L. statistical leadership in AIDS. cancer and Eichhorn, NlA scien1ist emeritus, was hon­ neurologic research, and for outstanding Dr. J. Carl Barrett, NlEHS scientific ored recently with a symposium, "Metals, service to the statistical profession ... Dr. director. has been awarded by the DNA, Transcription and Aging," which is Harold S. Ginsberg ofNlAID's Collegium Ramazzini. an international his field of research. Colleagues and fellow Laboratory of infectious Diseases was group of scientists interested in the study of scientists spoke about their c~urre111 research selected for the 1995 Outstanding Alumnus environmental and occupational health. its and his involvement and interest ... Dr. Award at Tulane Universiry School of 1995 Ramazzini A ward. He was honored Roselyn Payne Epps, who is in NCl" s Medicine: it was presented al the universi­ for '"distinguished scientific contributions to Division of Cancer Prevention and Control, ty"s homecoming festivities in New the understanding of the causes and mecha­ was honored with a symposium at the Orleans. His current research at IH focus­ nism or cancer'' ... Or. John E. Bennett of National Medical Association's annual es on pathogenesis or adenovirus. HIV and NlA ID has been elected vice president of meeting in Atlanta. She has developed anti­ SIV. Over the past 40 years, his work has the 5.000-membcr Infectious Diseases tobacco programs and the symposium was helped to shape the thinking of a generation Society of America. One of the nation·s titled: ··Tue Roselyn Payne Epps, M.D. of virologists and to introduce modem leading experts on systemic fungal infec­ Symposium: Prevention of Alcohol, research approaches to the field of virology. tions. Benneu is chief of t11e clinical mycol­ Tobacco, and Other Drug-Related Violence Ginsberg earned his medical degree from ogy section in the Laboratory of Clinical in African American Youth" ... Dr. Tulane in 1941 ... Dr. Mark Hallett, Investigation and direcL~ the infectious dis­ Anthony S. Fauci, director of NJAID. NINOS clinical director and chief of the ease clinical trnining program for NlAID ... recently accepted three distinguished honors Medical Neurology Branch, recently Dr. John D. Doice, Jr., chief or the for his contributions to biomedical research. received honors from the Benign Essential Radiation Epidemiology Branch. 1c1. Indiana Universiry School of Medicine pre­ Blepharospasm Research Foundation, Inc. recently received from the College of sented him with the Steven C. Beering (BEBRF). He was honored for the ouc­ Science at the University of Texas, El Paso Award: it honors recipients for their interna­ standing contributions. suppon. and advice its 1995 Gold Nugget Award. His research ti onally recognized contributions to the he has given the foundation for many years has contributed 10 knowledge of radiation­ advancement of biomedical or clinical sci­ and inducted imo BEBRF's Hall of Fame induced cancer ... Frances Bergling ence. He also delivered the 199th Lilly and given tlle Pylon. BEBRF's award for Cannon recently received a Distinguished Award Lectureship at the Lilly Research excellence. Pylon is the Greek word for Alumna Leadership Award from her alma Laboratories. Also, the Shipley Institute of gateway and his ''dedication and suppon mater. Seton Hill College in Greensburg. Medicine and Harvard Medical School have helped the BEBRF forge a gateway to Pa. She was honored for her achievement in invited Fauci to present a lecture at the the world for sufferers of blepharospasm science and for ''being an example of faith Eleventh Shipley Symposium on the /meige and hemifacial spasm"' ... Dr. Curt i~1 action'" ... Or. William Castelli, long­ Molecular Basis of Microbial Pathogenesis Harris, chief of the Laboratory of Human ume director of NHLBr s Framingham ... Or. Joseph F. Fraumeni, Jr., now direc­ Carcinogenesis in NCl's Di vision of Basic Hean Study, was honored with a sympo­ tor of NCrs Division of Cancer Sciences. recemly received several awards siu m that looked back at the study's Epidemiology and Genetics. recently including the most prestigious award of the groundbreaking research 47 years ago and received the John Snow Award from the International Union or Toxicology. the ahead to its future research. He is still stay­ American Public Health Association·s epi­ Deichmann Award, at the VII International ing with the srudy as a senior investigator. demiology section. The award was given Congress of Toxicology: the CllT Founders but he has also taken two new posts­ for "distinguished service to the public Award of the Chemical Industry lnsticuce of director of a new Cardiovascular Wellness health through outstanding contributions to Toxicology, and the Don Coffey Award of Clinic at the Metro West Medical Center in epidemiology"" ... Dr. Loretta Finnegan, L11e Society of Basic Urologic Research. Framingham and professor emeriLUs at the director of the Women's Health initiative Harris was honored for his ··outstanding Boston Universiry School or Medicine ... (WHI). was recently a distinguished speaker contributions to the field of molecular car­ Or. Robert M. C hanock, chi ef of NlAID's and visiting professor at the Uni versity of cinogenesis, including functional and struc­ Laboratory of Infectious Diseases. recently Texas Health Science Center, San Antonio. tural studies of the p53 tumor suppressor received another honor, the Alben B. Sabin She gave three lectures during the visit. and gene, and to tbe field of molecular epidemi­ Gold Medal. The award was given for his was presented with keys 10 the city. ology or cancer risk" ... Dr. Peler Kador, exemplary research in the field or vaccinol­ Finnegan related details of the 15-year, chief of NErs Laboratory of Ocular ogy. particularly the control of respiratory S628 milJjon WH J, which hopes to enroll Therapeutics. was recently honored with the diseases ... Dr. Charles E. Egwuagu, com­ more than 164,000 women at 40 medical Jin Kinoshita Lectureship award at the U.S.­ mander in the Public Health Service and centers across the country ... Dr. Mary A. Japan Cooperative Cataract Research Group senior research scientist in NEl's Foulkes, chief of the Biostatistics Research Meeting in Kona, Hawaii. Kador presented Laboratory of immunology. recently Branch in the Division of AIDS. has been a lecLUre. "Sugar Cataracts Revisited." This

22 SPRIN G 1 9 9 6

award is sponsored by the National American Medical Women's Association. annual scientific symposi um. He received Foundat ion for Eye Research and was Named for the fi rst woman physician the award for his progressive research that established in 199 1 to honor Dr. Jin 1-1. 1rained in !he U.S., the award ''honors a uses molecular techniques to demonstrate Kinoshita. fonner NEI scientific director, woman physician who has made the most the role of amino ac ids such as glutamate and a world-renowned cataract researcher. outstanding contribution to the cause of and glycine as neurotransmi11ers in the inner The award is presented every 2 years, with women in the field of medicine'' ... Dr. ear and in the brain's auditory pathways. recipients receiving a plaq ue and a $ 15,000 Clifton Poodry, director of the NIGMS honorarium ... Dr. Albert z. Kapikian, Division of Mi nority Opportunit ies in assistant chief of the Laboratory of Research. has been awarded the American APPOINTMENTS AND In fectious Diseases and head of the epi­ Indian Science and Engi neering Society's demiology section. NIAID. has been elected Ely S. Parker Award. The award recog­ PERSONNEL CHANGES presiden1 of !he American Epidemiological nizes American Indian scientists and engi­ Socieiy ... Or. William C. Knowlcr, chief, neers who have demonstrated outstanding Dr. Lynn M. Amende has been named diabe1es and anhritjs epidemiology sec1i on, li fetime achievements though professional director, Division of Extramural Programs, NIDDK. is the 1995 recipient of the work and service to the Indian community. of the National Institute of Nursing American Diabetes Association's Kell y He was presented the award and a tradition­ Research ... Dr. J. Carl Barrell, acting sci­ Wes1Award for outsttmding research in dia­ al Indian Pendleton blanket duri ng the soci­ enti fic director of NIEHS since December betes epidemiology. The award was pre­ ety's annu al meeting in Detroit ... Or. 1994 and since 1987 chief of the Laboratory sented al the association's annual scientific Christopher J. Portier, acti ng chief of the of Mole::ul ar Carcinogenesis. has been meeting. Knowler spoke on '·Epidemiology. Laboratory of Quantitative and Computa­ named scicntj fic director of the NIEHS Genetics. and Prevention: The Pima Indian tional Biology, NlEHS, has been named the Di vision of lntramurnl Research. Last year, Cont rib u1 ion" ... Dr. Thomas A. Kunkel, 1995 recipient of the Monimer Spiegelman hi s Laboratory of Molecular Ca rcinogenesis research geneticist in the Laboratory of Award by 1he American Public Health generated two landmark achievements in Molecul ar Ge netics. NIE HS, delivered the Association. The award is made to a stati s­ NIEHS history. Scientists there we re mem­ G. Burroughs Mider Lecture, on "DNA tician under age 40 for outstanding contri ­ bers of the team that isolated the breast can­ Replication Fidelity, Mismatch Repair, and butions to the field of health statistics, and cer suscepti bility gene, and in May. Barrell Genome Stability." on Nov. I, 1995 ... Or. was presemed to him on Oct. 31, 1995, at

23

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... Dr. Lewis K. Schrager has been named the Office of Ex tramural Research ... Dr. Special Recognition Award for outstanding chief of the Epidemiology Branch in the Stephen L. Gordon, the first chief of the and effecti ve efforts in launching the "Back Basic Science Program of NLAID 's Muscul oskeletal Diseases Branch. NJAMS, to Sleep" media campaign in the public Division of AIDS ... Dr. Lana R. Skirboll, recently retired after 30 years of govern­ health battle against Sudden Infant Death fonncrly with the National Institute of ment service. He came to NIH in 1978 as a Syndrome ... Dr. Da\lid Rodbard, DCRT Mental Health. has been named associate grants associate and developed fields of director for the past 5 years, whose clinical director for science and technology transfer research in the musculosketaJ arena such as and basic research career spanned two insti­ policy. OD ... Dr. Sharilyn K. Stanley has low back pain, osteoporosis, osteoanhritis. tutes and the study of endocrinology. math­ been named special assistan t for science spons medicine, and repetiti ve motion dis­ ematics, stati stics, and computer science, policy in the Office of NIAID director Dr. orders. He is looking forward 10 a second retired Apr. I after 30 years of service co Anthony S. Fauci, and liaison to the NIH career in the private sector. working in Lhe NlH. He will join the Association of Office of AJDS Research. biomedical fields of injury prevention and American Medical Colleges in Washington, onhopaedic treatments ... Dr. Lee Van D.C .. as director of information resources Lenten has retired after 24 years with the outreach and liaison activities ... Raymond RETIREMENTS Public Health Service. 19 of them with T. "Ray" Rusten, Sr., laboratory t~hni­ NIGMS. At the time of his retirement, he cian at the NfNDS Electron Microscopy Or. Ronald Dubner, chi ef ofNIDR's was serving as acting chi ef of t11e Facility, has retired. He began his career as Neurobiology and Anesthesiology Branch Phannacological and Physiological a nu rsing aide at the Clinical Center in and head of the NIH/N lDR Pain Research Sciences Branch. NlGMS, where he admin­ 1960. Fi ve ye11rs later, he became a biologi­ Clini c, retired in June 1995, ending a 36- istered a ponfolio of research grants in the cal laboratory aide al NIAID. In 1970. he year career in the PHS Commissioned area of physiology and tmuma and bum moved to Cl where he specialized in elec­ Corps that included 33 years at NIDR. He injury. He also administered the NIGMS tron microscopy. He spent the last 17 years has joined the University of Maryland Medical Scientist Training Program grants working in the Laboratory of Viral and School of Dentistry as head of oral and ... Wanda "Claudie"' Pifer, who recently Molecular Pathogenesis and at the NI OS craniofacial biological sciences. retired from NLH after 38 years of govern­ faciliry. In his rctiremcl)L. Rusten says he lntemntionally recognized as a pioneer and ment service. has served since 1988 as will "enjoy a life of leisure," which will leader in the field of puin research, Dubner immigration coordinator at FJC's include fislting, traveling, "puttering around is accla imed for building a world-renowned International Services Branch and officer the yard '' and volunteering ... William pain program at NTH and for his many con­ for NLH's JI Exchange Visitor Program. Stancliff. visual information specialist for tributions to the understanding of the neuro­ She came to NIH in 1957 and was responsi­ DRG's Grants Information Office. recently biological mechanisms of pain ... Dr. ble for reservations for NlH conference retired after 38 years of government service. James R. Fouts, senior scient ific advisor to facilities. In 1960, she joined the Clinical He started his federal service with the the director of NIE HS, has retired after Center special events office and handled National Bureau of Standards in 1959 as an more than 25 years as a scientist with the international visitors to the campus. She engineering draftsman. Ln 1969. he left to government. and more than 40 years in sci­ was appointed chief of the International join DRG's Statistics and Analysis Branch. ence. I-le has been in the fronti er of the Visitors Center in 1980 and when the FIC In retirement. he plans to continue doing his development of toxicology and environ­ Foreign Scientist Assisiance Branch was volunteer work with the Clinical Center and mental health sciences as developing disci­ established in 1982. she was appointed the R& W and spend time fishing ... plines for his entire career. He also has a chief. She plans to travel and spend more Elizabeth Tully, an accounting technician second career as an ordained Episcopal time with her family. especially her grand­ with the National Institute of General priest. Holder of a master's of diviniry son ... James M. Pike, executive officer in Medical Sciences, retired recently after 32 degree, summa cum laude. from Duke the Office of the Director, Division of years of government service. 23 of them University, completed in 1984, he has been Research Grants, retired recently after 36 wit11 NIGMS. Prior to joining NlGMS. she priest associate at Chapel of the Cross. years of federa l service. He started out al spent 8 years wi th the Internal Revenue Chapel Hill, N.C .. since 1989. He and his DRG and returned there in 1986. He also Service and I yellf with the New York State wife will continue to reside in Chapel Hill, worked at NHLBI. Both at NHLBI and Social Security Administration. She plans to N.C .... Dr. George Galasso has retired DRG. Pike was supervised by Dr. Jerome enjoy retirement with her husband and four after 30 years of federal service. His NLH Green, former director of DRG, who grandchildren ... Wanda WarddeJI recently career hns included bolh scientific achieve­ praised Pike's management skill. loyalty. retired after 13 year: at NIH. She beg:m her metlls and administrati ve end eavors, espe­ and allegiance to N.IH ... Michaela career in 1962 with the Division of cially in program management. In 1969, he Richardson, infornrntion officer for the Research Faci lit ies and Resources. She was responsible for the initiation of the Nati onal Institute of Child Health and trans ferred to NIGMS in 1965. At the time Antiviral Substances Program and also was Human Development. has retired after near­ of her retirement. she was a public affairs named in 197 1, chief of NIAI D's Infectious ly 25 years of government service. specialist and Freedom of Information and Diseases Branch. In 1983, he was appointed Seventeen of those years were spent at Privacy Act coordinator in the lGMS to dual positions as NIH associate director NICHD. which she joined in 1978. Office of Research Repons. for exLramural affairs and deputy director of Richardson recemly received t11e PHS

25 N I H A A U P D A T E

DEATHS Lebanon N.H. of prostate cancer. He was than 20 years before retiring in 1976. died past president of the Mt. Sinai School of of congestive heart failure Jan. 14 at Hattie D. Arnold, 96. died July 23, 1995. Medicine and an expen on randomized clin­ Suburban Hospital ... Carol Aon Evans, a Following World War Tl. she joined the ical rrials to detennine the best course of librarian at the National Library of newly fonned research grants program for medical treaonent. From 1970 to 1973, Medicine. died on Sept. 27. She had multi­ mental health at NIH. where she worked Chalmers was director of the Clinical ple myeloma. At NLM, she helped manage unti l her reti rcmcnl in 1969 ... Dr. Kathrvn Center and deputy director for clinical care the National Network of Li braries of Ballard, 65, a scient ific review officer fo~ ... Hazel Johnson Chambliss, 89, a grams Medicine. During her career she received a NHLBl's research 1raining review commi l­ officer who retired in the late 1960's after number of awards, includjng the NIH Merit tee in th e Division or Ex1ramural Affairs, 15 years with NlH, died of cardiopul ­ Award ... Dr. Aaron Ganz, 72. a pham1a­ died of cancer on Aug. 15 at Dea1on monary arrest Feb. 14 at the Cherrydale cologist who retired in 1986 as special Hospital in Ba ll imore. In 1987, she joined Retirement and Health Center in Arlington assistant for centers and mhcr programs at NHLB I and no1on ly did she run the insti­ ... Michael Anthony Chirigos, Jr., 36. a NIDR, died of stomach cancer Mar. 4 ai a tute's training commiuee. bu1 was uc1 ive in medical srudent and a mo lecular biologist. hospital in Encinitas, Calif. When he first overall training efforts, including !raining died of a blood disorder and renal and liver joined NTH he worked in Lhe Office of the gra nts and student training awards ... failure Aug. 15 at Fairfax Hospiial. He had Director. At NLDR. he was chief of the J ames B. Black, 81. a safety engineer who become i II after a heart transplant in General Oral Sciences Program. the Pain retired in 1973 after 25 years at NIH. died October 1994. He had worked in the pcdi­ Control and Behavioral Studies Program of congestive heart failure Oct. 22 at a nurs­ :uric branch of the National Cancer Institute and the Office of Program Planning~and ing home in Vero Beach. Fla. He moved to before entering medical school ... Evaluation ... Margaret S. Geiger, 64. a Vero Beach in 1974 ... Virginia "Ginny" Genevieve P. Daggett, who worked for nurse epidemiologist. died after a hean Berger Brenner, 47. died of complications NlAID in the Division of Microbiology and attack Feb. 12 at her home in Silver Spring. related to pneumonia on Jan. 27 at Bethesda Infectious Diseases, died Jan. 28 after an She moved to this area in the 1950's and Naval Medical Center. From 1970 until accident at her home. When she first joined began working at the f[H's branch of 1986. she was an office assistant at IH. NlH. she worked in the Division of infectious diseases. After she left 1 IH. she After she left NIH. she earned a master's Legislative Analysis ... Barbara W. worked at Sibley Memorial Hospital for 25 degree in educational guidance and counsel­ Danforth died on Jan. 17. She worked as a years where she helped establish the Gift of ing from Howard University and worked as supervisory clearance assistant at the Peace Home for AIDS Patients in a foster care specialist and substitute teacher Journal of the National Cancer l11stit11te ... Washington ... Anne Mudd Gibson, 79. ... Dr. John B. Calhoun, 78. died on Sept. Dr. Allen T. Dittman. 74. a NIMH psy­ who retired in 1975 as an assistant adminis­ 7 while on vacation in Hanover, N.H. I-le chologist who later worked at the trative officer at the National Institute of had a s1roke after a mi ld heart attack. A sci­ Department of Education. died Oct. 3 at Mental Health. died of cancer Feb. 22 al the entis1at NIMH starting in 1954. he had con­ Suburban Hospital of a stroke after renal home of her daughter in Odum. Ga. She duc1ed experiments wit h laboratory mice bypass surgery. rn 1954, he joined the staff joined NlMH as a secretary in 1954. Later. and ra ts demonstrating th lll exireme crowd­ at NIM H after having worked as n clinical as an assistant admini~trative officer, she ing led to social isolation nnd eventual psychologist at the University of Michigan. received the Superior Service Award of the extincti on. In 1963. he organized !he un it He was the author of l111erperso11a/ Department of Health. Ed ucation and for research on behavioral systems al 1he Messages of Emotions, which he wrote Welfare ... Dr. Peter L. Golway. chief of Laboratory of Brain Evolution and whi le on sabbatical at the Institute of NIAID's Animal Care Branch. was killed Behavior at NIMH. He continued as chief Fi lrnology in Milan ... Robert Charles on Oct. 12 in an au tomobile accident near of the unit until his retirement in 1986 ... Dutky, 53, an engineer who worked in his home in Hedgesville, W.Va. ln 1980. J ohan Widding Heiberg "J an'' mass spectrometry at the Laboratory of he joined NIAID and proceeded to organize Cammer mcyer, 85, a neuropnthologist Biophysical Chemistry. NTI I. died after a one of the lnrgcs1 animal units at NIH . Not who retired in 1980 from NIH, died Feb. 15 hean attack on Oct. 27 at Suburban only did he provide clinical and diagnostic at a hospital in Montevideo. Uruguay. after Hospital. He joined tJ1e laboratory in 1990 services to approximately 137 .000 animals intestinal surgery. He was visiting a son in and his research focused on the analysis of per year. he also managed all ofNIAID' Uruguay when he died. He joined NIH in the spectra of substances ... Estalla K. laboratory facilities on the NIH campus and 1956 and had published extensively in med­ "Kepie" E ngel, 74. a retired associate pro­ oversaw the instilute·s four off-campus ical journals ... Ruth R. Ceccarelli, 80. gram director at the ational Science facilities. He was one of the major authors died on Jan. 10 after a stroke. She first Foundation. who also worked at NIH. died of animal care and use guidelines used by came to work at NIH in the J960's for the of cancer Mar. 2 at Carriage Hill Nursing all of IH ... Irving Goldberg, 77. died in PHS's Division of Finance and then moved home in Bethesda. She began working at January 1996 in New York. He had joined over to NICHD. In 1972. she worked at NIH in the early I950's as a biologist and NIH in 1970 after having worked in DHEW DR R and then from 1975 to 1986. when she left in 1960 to join the NSF. She retired in for 20 years. He was one of the founders of retired. she was at NIA as secretary 10 the 1989 as associate program director in bio­ the ''Ad Hoc Players." Tn 1980, he retired executive officer ... Or. Thomas C. logical and medical science ... Evangeline as the director of public infonnation at NIH Chalmers, 78, died on Dec. 28 at Z. "Evelyn" Ellison, 85. a personnel ... .J erome L. "J erry" Gordon, 78. a Dartmou1h 1-lilchcock Medicul Center in administrator who worked for NIH for more retired NIH editor and fonner Muzak man·

26 SPRING 1 9 9 6

ager, died on Mar. 29 of cancer at Fairfax to the NIH Division of Zoology in 1937, medicinal chemistry ... Edwin MacKelsey Nursing Home. In 1971. after worki ng for beginning an NlH career that spanned Lamphere, 7 1, a sanitary engineer and pub­ Muzak, Gordon joined NIH as a science almost 42 years. During that time. except lic heal th oflicer who retired in 1973 from writer in the Office of Health and Science for service in World War II and 2 years as NIH, d.ied of a lung ailment Dec. 2 at Repons. He became editor of the NIH secretary for science in the Department of Bethesda Naval Hospital. When he retired Record in 1981 and retired in JQ82 ... Health. Education and Welfurc from 1967 from NIH. he was dc.:pu1y director of the Selma Greenhouse, 75, a fonner secretary to 1969, he served NIH wit h disti11c1i on in bureau of community environmenial man­ at 1he National Institute of Mental Health, numerous positions. He was very active in agement at NfH and director of the Public died of lung cancer and respiratory failure the formation of the NIH Alumni Health Service's area human ecology cen­ on Jan. I at her home in Silver Spring. In Association and was a founding member of ters ... Virginia Sharon Larkin, 46, a com­ 1988, she retired from NIMH after 15 years the board and chairman of the historical puter assistant at NIH for about IS years, of service. Once retired, she worked as a co111111i1tee ... Dr. .J ohn Ka llos, 70, a mole­ died Jan. 19 at Suburban Hospital after a volunteer at the Holocaust Museum ... Mel cular biologist who founded the Sustainable heart attack ... Robert Allen MacLean, 7 1, Harding, 71, who managed NIDR's Development Initiative, a forum at the a retired medical records clerk at NIH, died Animal Care Uni t until his retirement in Columbia University Graduate School of of congestive heart failure Jan. 29 at his 1992, died on June 6 at his home in Business for environmentalists, academics home in Falls Church. He had retired in Rockville, Md .. fo ll owing a massive heart and business people, died Feb. 25 of a heart 1989 having worked at NIH for four years anack. He first joined the government in auack in New York. Jn the I 970's, he ... Dr. Dorothea Starbuck Miller, 86. who 1945 as a laboratory technician with what worked at NIH in the Molecular Biology served as program director of grant s a1 NIH was then the National Institute of Health. Laboratory ... Howard Kettl, 76, who f'rom 1964 to l 986, died Oct. 17 of a heart In 1953, he came to NIDR as an animal care retired as executi ve officer of the Clinical ailment at her home in Bethesda. Before technician and went on to help establish the Center at NIH in 1981. died of cancer Sept. moving to the Washingion area and joining institute's germ-free animal unit. Harding 25 at his home in Rockville. He began his the staff at NfH in 1964, she served for 20 was cred ited by the in vesti gators who career at NIH in 1952 as a linancial nnalyst years on the faculty of the Un iversity of worked wi th him for changing the insti­ at the Clinical Center. In 1953, he left the Chicago where she was dean or the division tute's perception of animal care and for hospital to become NIH systems accountant of biological sciences ... Or. Moreshwar V. helping guide NIDR into the modem era of in the Office of Financial Management. Nadkarni, 78, fom1er chief of 1he laboratory animal science ... Freddie Then as a deputy associate director of Extramural Research and Resources Harris, 56, an administrati ve technician administration, he helped create the NIH Branch, Developmental Therapeutics with NIC I-ID, died Feb. 8 at Georgetown Oflice of International Health and the Program, NCI. died Aug. 2 at Fernwood Un iversity Hospital after a brief illness. He Office of Grants and Contracts. During his Nursing home from complications of a began hi s career wi th NLH in August 1970 five-year ten ure as CC executive officer, he stroke. Nadkami, who retired in 1986. as a messenger in the Office of the Director. oversaw the construction of the Ambulatory worked at NCI for 30 years. initially as a A year later. he joined NfCHD. where he Care Research Facility. He was a member researcher in chemotherapeutic agents. remained ... Bowen Isaac Hosford, 78. a of the NTH Alumni Association board of Much of his NIH career was spent in grants retired Air Force major and a retired NIH directors and chninnan of the budget com­ admi nistrati on, supervising and managing public in formation offl cer who had also mittee ... Dr. Norman Krctchmer, 72, for­ grants and comracts dealing with 1he phar­ practiced law in Vienna since 1986. died of mer director of the National Institute of macology of newly developed anticancer cardiopulmonary failure Nov. 13 at Fairfax Child Health and Human Development agents. At 1hc time of his retirement, the Hospital. He came to NIH in 1966 to work from 1974 to 198 1, died Dec. 20 in the Ex tramural Research and Resources Branch at the CC and then in 1969, he moved to the Moffeu Hosp i111l of the Uni versity of had overseen more than 450 research pro­ Oflice of Comm unications to administer the California at San Francisco from kidney jects ... Celia E. Pappano Paine, 89. who Freedom of Information Act. He left in the failure due to myeloid metaplasia. An worked for NrH from 1941 until retiring in late I980's ... Phili p .Janus, 78, a retired expert on infant nutrition, he was professor 1970 as a senior supervisory auditor, died of NIH program planning offi cer, died of pan­ emeritus of nutrition at the University of a heart ni lment Sept. 16 at her home in creatic cancer Sept. 13 at his home in California at Berkeley and professor emeri­ Kensington ... Dr. Margaret Pittman, 94. Bethesda. Before joining NIH in 1948, he tus of obstetrics and pediatrics at the San a retired NIH scientist who worked on the had worked at the U.S. Census Bureau and Francisco campus. At his death he was ed i­ development of vaccines 10 prevent typhoid. the Office of Price Administration. He tor in chief of' the AmeriC"a11 Jo11mal nf cholera and whooping cough. died Aug. 19 retired in 198 1. Foll owing his retirement, Cli11ical N11tritio11 ... Dr. Carl A. Kuether, at Prince George's Hospital Center in he tutored students in several languages and 80, former NIGMS program director. died Cheverly. Md. She had kidney failure and volunteered with Meals on Wheels ... Dr. on Feb. 2 1 after suffering a heart auack. He congesti ve hea rt fai lure. Piuman joined Leon Jacobs, 80, director of the Fogarty retired in 1994 artcr 32 years of government NIH in 1936 as a bacteri ologist. In 1958, lnternuti onal Center from 1978 to 1979. and service, 28 of which he spent with NI GMS. she was appointed chief of the Laboratory an internationally recognized parasitologist During his career there. Kuether adminis­ of Bacterial Products, thus becoming the known for his work in toxoplasmosis-relat­ tered grants in 1hc areas of natu ral products lirst woman to head a major lab at NIH. ed blindness. died of cancer at his home in chemistry, syn1hctic organi c chemistry, She remained in th at job until retiring in Washington. D.C .. on Oct. 3. Jacobs came chemical reac tions and mechanisms. and 1971. bu t she continued working in retire-

27 N I H A A UPDATE

ment unti l suffering a stroke in 1993. In A. Taschman, 72, a retired NIMH social retirement, she was a consultant 10 WH O in worker, died Mar. 25 at home in Bethesda. Cairo and Madrid. She had also consulted He had a heart ailment. He worked for 25 for the State Institute for Serum and years at N1MH before retiring around 1980. New Publications Vaccine in Iran and Connaught Following his retirement, he worked in Laboratories Ltd. in Toronto ... community psychiatric clinics in About NIH History Or. David Rosenthal, 77. an expcn on Montgomery County, specializing in the use schizophrenia and the role that genetics play of menta.I heahh therapy programs such as in the disorder, died Feb. 26 at Calven psychodrama ... Dr. Yale Jerome Topper, David G. Nathan, Genes, Manor nurs ing home in Ri sing Sun, Md. 79. a retired research scientist at NIH, died A Boy He had Alzheimer's disease. From 1955 to Oct. 26 at Georgetow n Uni versity Hospita l. Blood, and Courage: 198 1. when he retired. Rosenthal worked He had leukemia. He worked at NIH, con­ Called Immortal Sword. for the Nati onal Institute of Mental Health. ducting research on breast cancer and di a­ Cambridge, Mass.: Belknap It was there that he did his study of li ves or betes. for more than 30 years before retiring Press of Harvard University four siblings known as the Genain in 1987. His work focused on the role of Press, 1995. ix, 276 p., iU. Quadruplets, all of whom suffered from hormones in the development of the mam­ Includes bibliographical schizophrenia. His subsequent studies on mary gland. He also was chairman of $24.95. psychiatric genetics were published in Tire NIH's Experimental Biology Task Force references (p. f2 50l) and index. Tra11smissio11 ofSc/1i:oplrre11ia co-wri11en for Cancer ... Sue M. Valentino, who A first-hand account of Dr. with Dr. Seymour Kety and Genetic Theory worked at NIH in the Office of the Di rector Nathan's research on beta tha­ and Abnormal Behavior. Although he dis­ Board of U.S. Civi l Service Examiners from lassemia. covered evidence of genetic transmission. November 1948 until she reti red in he was always carefu.I 10 note 1ha1 it was not December 1965, died May I, 1995, in Mt. the onl y cau se of schizophrenia ... Michele Airy, Md . ... Dr. Rudolph "Rolf" Wanner, Caroline Hannaway, Victoria Foye Shevitz, 49, head purchHsing ugc11 1 u1 75, who worked u1 DRS in 1hc 1970's, died A. Hurdcn, and John NIH 's neurology and cancer institutes, died of esophageal cancer on July 19, 1995 in Parascandola, Eds., ALEJS and Mar. 8 in a car accident in Howard County. New Smyrna Beach, Fla. He had been rite Public Debate: Historical She began her career al NIH in 1967 ... Dr. associate director for environmental health and Joel Marti n Solomon, 63. former chief and safety in DRS in the l 970's ... Dr. Co111emporaiJ' Perspectives executive officer of the American James Watt, 84, died of prostate cancer on (Amsterdam and Tokyo: IOS Association of Blood Banks, died of com­ Aug. 22 at Sentara Norfolk General Press and Ohmsba, 1995) viii. plications from a brain tumor. on Dec. 27 at Hospital in Norfolk. Va. As a member of 2 16 pp., ill. $70.00. One section the Shady Grove Nursing Center in Shady the Commis-sioned Corps of the PHS, he on the response to AIDS within Grove, Md. In the I950's he worked at served as director of the National Hean the U.S. Public Health Service NIH ... Dr. Nat Sternberg, 53. a molecul ar Institu te from 1952 unlil 1961. For several bi ologist whose scientinc specialties includ­ years prior to hi s appointed as NHl director, and its agencies, including the ed DNA recombinati on and gene regulation. he was in charge of the field laboratory of NIH. and who was a former staff member at NIH, the National Microbiologic:1 l Institute (now died of cancer Sept. 26 at Chester County NIAID) located at Louisiana State Nathaniel I. Berlin, "The Hospital in Pennsylvania. He joined NIH in University Medical School. He directed NHl Metabolism Service," Cancer 1971. From 1976 until L983, he was a labo­ nearly 9 years. until accepting an appoim­ ratory director at the Frederick Cancer ment to head the Office of International lnvesrigarion 1995; 13(6): Research Center. In 1984 he joined Dupont Hea.lth, PHS. In 1967, he became special 637-45. An historical account of in Wihnington and at his death he was a sci­ assistant 10 the surgeon general for program the Metabolism Service wrirten entist with Dupont-Merck Pham1aceu1ical review until he retired in December 1968 ... by one of its leaders. where he directed molecular biology Alline Volpe Weeks, 74. a retired NIH researc h on cancer therapeutics ... Harvey employee. died Dec. 2 111 the Washington Hospital Center after surgery ror a heart ail ­ Comment on Berlin paper by ment. She worked for NIH from 1963 until Thomas A. Waldmann: "The retiring in 1972 tL~ a grnnis administrator ... Metubolism Bmncb: An The NIH Alumni Association Margaret Ridgley Welsh, 74, who retired Exemplar of Patient-Oriented in 1983 after about 14 years as a writer and has received contributions in Research." [editorial; comment! memory of Christian B. editor at NlH. died of cancer Jan. 22 at Holy Cross Hospital ... Anita Valenti ne Cancer Investigation Anfinsen, Leon Jacobs, Wertheim, 72. an anist who had exhibited 1995: 13(6):662-3. Howard Kettle. and Sue M. her paintings at local galleries, died of can­ Valentino. cer Dec. 31 at her home in Silver Spring. She was a secretary 111 NIMH in the I960's .

28 SPRING 1 9 9 6

BALLOT

NATIONAL INSTITUTES OF HEALTH ALUMNI ASSOCIATION

PLEASE TEAR OUT AND RETURN WITH YOUR VOTE

In accordance with the bylaws of the NLHAA, alumni members of the association are to elect one-third of the board of the association. The nominating commiuee, appointed by President Calvin B. Baldwin, has nominated the alumni mem­ bers listed below, each of whom has agreed to serve on the board of directors if elected, to occupy positions on the board left open by expir ing terms of office of presenc members. Each alumnus(a) member may vote for four of these nomi­ nees. Please note that associate members (current NIH employees) are not eligible to vote in this election.

NOMINEES FOR BOARD OF DIRECTORS

Please vote for up to four (4) and return your ballot to the NIHAA office by June 1.

0 DR. WILLIAM R. CARROLL- Scientist, NIAMD*

0 DR. GEORGE COSMIDES - Associate Director, NLM, Consultant

0 MS. JOAN FREDERICKS - Health Scientist. DRG, Consultant

0 DR. LLOYD LAW - Scientist NCI

0 DR. LOIS LIPSEIT - Special Assistant to Director, NIDDK, now at American Diabetes Association

0 DR. SEYMOUR PERRY -Associate Director, NIH*

0 DR. PAUL PETERSON - Associate Director, NIAID*

0 MS. HAZEL REA - Senior Advisor to Director, NTMH

0 DR. MARYE. SEARS-NCI Scientist, Past NIHAA Secretary*

0 DR. EL WOOD TITUS - Scientist, NHLBI, Cons ultant

*CURRENT BOARD MEMBERS ELIGIBLE FOR A SECOND TERM.

29 SPRING 1 9 9 6

NIH Retrospectives with $99 million in 1956 ... The annual Hamster show. .. Life at NIH.'' will be presented on May 24, 25, and 26, 1956. This year's presentat ion comes under the title of"Health's a-Popping'· and includes a cast of over 50. Spring 1976

Spring 1956 A confe rence on a new issue in generics and its potential impact on sci­ A short ceremony was held in ence and society was held Feb. 9- 10. Wilson Hall at 4 p.m. on Jan. 31, 1956. 1976, at NlH. The Ad visory for the unveiling of Dr. Wi lliam H. Comminee to the NIH Director and Sebrell, Jr. 's portrait. The former NIH Spring 1966 other participants considered proposed director's painting. done by Mr. Bjorn guidelines and requirements for NIH Egeli, was fi nanced by contri butions Dr. Roy Hertz, scientific djrector of support of recombinant DNA research from NIH employees ... An increase of the National Institute of Child Health ... A symposium in memory of Dr. 28 percent over the total NIH appropri­ and Human Development, admitted Gordon M. Tomkins was held all da y ations for the current liscal year was NICHD's first pati ent 10 the Clinical on Feb. 2 and 3 in Wilson Hall. recommended by President Eisenhower Center on Jan. 16. 1966. thus marking Tomkins. a pioneer in the field of hor­ when he presented his Health Message another mjlestone in the history of clin­ mone research. died July 1975 follow­ to Congress on January 27. The pro­ ical research at NIH. Hem had also ing brain surgery. He had been with NlH for 14 years and was former chief posed NI H budget for fi scal year 1957 admitted the fi rst patient to the Clinical requested $ 126.5 mi II ion as compared Center 13 years before. of the Laboratory of Molecular Biology. NLAMDD. He left here in 1969 to become professor of biochem­ istry and vice chai rman of that depart­ ment at the University of Californ ia at San Francisco. the position he held at the time of his death.

lheNIH Record

Spring 1986

Dr. G. Burroughs Mider. 78. former depury di rector of the National Li brary of Medicine and director of Labora­ tories and Clinics at NIH , died Dec. 12, 1985, after a brief illness. He was President Clinton visited NIH on Aug. 5, 1995, stopping first at the Children's Inn to meet widely known as a teacher. writer. and patients, famil!e~ and staff and broadcast his weekly radio address. Later he spent nearly 2 science administrator. An NfH lecture hours at the Ch~1cal Cente r whe re he received a science briefing and visited some patients. series, the ··c. Burroughs Mider NIH Above, the president holds 8-month-old Paige Knussman (a visitor, not a patient) of Ea ston, Lectureship.'' was established in his Md., as her parents Kevin and Kim look on. President Clinton is the 7th president to visit honor in 1968 and continues today. NIH . The others were: Presidents Roosevelt, Truman , Johnson, Ford, Reagan and Bush .

31