Sponsorship

FRAXA is joining hands with communities around the world to Prospectus raise Fragile X awareness while accelerating progress toward effective treatments and ultimately a cure for those living with Fragile X. July 22, 2021

Global Initiative of FRAXA Research Foundation World Fragile X Day 2021

World Fragile X World Fragile X Day began with FRAXA Research Foundation’s vision of joining hands with communities around the world to raise Fragile X awareness while accelerating progress toward effective treatments and ultimately a cure.

This global event is a day to celebrate families impacted by Fragile X syndrome and the progress of research to find a cure. On Fragile X World Day, we shine a light on this disorder by illuminating monuments and landmarks around the world.

What is Fragile X? Fragile X is the most common known cause of inherited intellectual disability and the leading known single gene cause of autism. Fragile X occurs when a single gene shuts down -- a gene vital to normal brain function.

Light It Up! In 2018, the Niagara Falls Illumination Board agreed to light up Niagara Falls in FRAXA’s signature teal to celebrate Fragile X awareness. A year later, 22 landmarks were illuminated, and in 2020, the total rose to 67 in the U.S.! Throughout the U.S. and Canada and across the pond in Dublin, Ireland, FRAXA brought awareness to Fragile X by lighting up the sky teal. Our friends in Australia lit up 64 landmarks across their continent in 2020.

This year, 200 landmarks world-wide have already confirmed their participation, and this is just the beginning!

" W o r l d F r a g i l e X D a y i s i m p o r t a n t t o m e b e c a u s e i t g i v e s t h e F r a g i l e X c o m m u n i t y a n o p p o r t u n i t y t o h a v e a v o i c e i n u n i s o n . T h e F r a g i l e X c o m m u n i t y i s k n o w n t o h a v e f i e r c e a d v o c a t e s a n d a n i n c r e d i b l e b o n d t h a t i s u n l i k e a n y o t h e r s y n d r o m e . W o r l d F r a g i l e X D a y g i v e s u s h o p e o f r a i s i n g a w a r e n e s s a n d f i n d i n g a n e f f e c t i v e t r e a t m e n t a n d u l t i m a t e l y a c u r e f o r F r a g i l e X a n d r e l a t e d c o n d i t i o n s . " K e l l y M e n k e R a n d e l s C o l e m a n , p a r e n t Funding the Cure with Our Partners

Since 1994, FRAXA has funded more than $30 million in biomedical research around the globe, yielding discoveries What FRAXA does goes far beyond that are changing the lives of families coping with Fragile X. what most people think of as In addition to funding university-based researchers, FRAXA “research.” We are running a massive partners with pharmaceutical and biotech companies large engineering project. We are and small to enable Fragile X development programs. constantly troubleshooting this complex project and making A Few Examples adjustments.

The FRAXA Drug Validation Initiative (FRAXA-DVI) in We have now validated dozens of Santiago, Chile, provides speedy, cost-effective pre- potential therapeutic strategies clinical testing of potential Fragile X treatments. which are ready for clinical trials. Through FRAXA-DVI we partner with pharmaceutical companies to test their compounds in Fragile X. Over 100 compounds have been validated to date, leading to FRAXA RESEARCH many clinical trials. 3 Areas of Focus FRAXA contracted with Healx, a UK-based drug repurposing company, to use artificial intelligence to 1.Gene Therapy and Protein generate a list of promising available drugs, singly and in Replacement Reversing Fragile X combinations, to tackle Fragile X. Based on this study at its core, by reactivating or with FRAXA, Healx was able to launch their global global repairing the silenced gene Rare Treatment Accelerator program which aims to 2.Translational Research repurpose drugs for 100 rare diseases. Repurposing available When Tetra Pharmaceuticals developed a promising medications for Fragile X PDE4D inhibitor with potential to treat Fragile X, 3.Clinical Trials FRAXA provided preclinical testing and funded a Funding treatment trials of new successful phase 2 clinical trial. A phase 3 trial is and available drugs for people expected to begin within months. who have Fragile X SPONSORSHIP OPPORTUNITIES

M R E U 0 D 0 I 0 N 0 E 0 0 0 I 0 T L M T I ,0 ,0 ,5 ,0 SPONSORSHIP O E A L 0 G 1 R 2 5 E 1 $ $ L $ BENEFITS P P $ Inclusion In Official World Fragile X Day Promotions

Social Media Campaign Recognition

Recognition On World Fragile X Day And FRAXA Websites

Logo On Event T-Shirt For Purchase By The Community

Volunteer Opportunities

Inclusion In Event Recaps On Social Media, Website, And Email Blasts

Invitation To Virtual Gathering Of Researchers And Industry Leaders

1:1 Access To Top Experts In The Fragile X Field

Logo On Promotional Email Blasts

Named FRAXA Research Award

Generously Featured In Official World Fragile X Day Promotions

Feature 1:1 Interview With FRAXA

Custom Opportunities - Talk To Us! Landmarks Confirmed For 2021 UNITED STATES Philadelphia's Ben Franklin Bridge, PA Franklin Square Fountain, TAS RSA Battle House Tower, AL Philadelphia's FMC Tower, PA Lake Wendouree Fountain, VIC Trustmark Bank Building, AL Trenton Makes The World Takes, PA Eureka Memorial Park Fountain, VIC Van Antwerp Building, AL Gulf Tower, PA Wodonga Water Tower, VIC RSA Plaza & Tower, AL Koppers Building, PA Monash Park Tree, VIC RSA Dexter Avenue Building, AL Sakonnet River Bridge, RI Council Offices, VIC Union Plaza, AR Korean Veterans Memorial Bridge, TN The Warrnambool Art Gallery, VIC Lighthouse Theatre, VIC Tucson's Historic 4th Avenue Underpass,AZ Metro Nashville Courthouse, TN Archie Graham Community Centre, VIC M on Box Springs Mountain, CA Houston City Hall, TX Melbourne Star, VIC Los Angeles US Bank Tower, CA Montrose Bridges over Highway 59, TX Flinders Street Railway Station, VIC 140 New Montgomery, CA TX: Alamo Quarry Smokestacks, TX McNichols Civic Center Building, CO Melbourne Town Hall, VIC Clark Nexsen Building, VA Delaware State Capitol Building, DE Old Treasury Building, VIC Two Union Square, WA The Wheel at ICON Park, FL Bolte Bridge, VIC Seattle's Evergreen Point Floating Bridge, King and Queen Towers, GA Bendigo Conservatory Building, VIC Aloha Tower, HI WA Ballarat Town Hall Clock Face, VIC 875 North Michigan Avenue, IL Columbia Center, WA Mooroopna Water Tower, VIC Wrigley Building, IL The Pfister Hotel, WI Catanary Lights, Geelong, VIC Regions Tower, IN West Gippsland Arts Centre, VIC Martin Luther King, Jr. Memorial Bridge, IN The Bell Tower, WA Shawnee City Hall, KS AUSTRALIA Matagarup Bridge, WA Flint Hills Discovery Center, KS Telstra Tower, ACT Perth Concert Hall, WA Council House, WA Mercedes-Benz Superdome, LA National Carrillon. ACT His Majesty Theatre, WA Leonard P. Zakim Bunker Hill Memorial Old Parliament House, ACT Queens Park Theatre, WA Bridge, MA Manly Town Hall, NSW Sky Ribbon Bridge, WA Kenneth F. Burns Memorial Bridge, MA Newcastle City Hall Clock Tower, NSW Medford City Hall, MA Mounts Bay Bridge, WA Fragile X Association of AUS HQ, NSW Longfellow Bridge, MA Yagan Square, WA Albury Entertainment Centre, NSW Fore River Bridge, MA Elizabeth Quay Bridge, WA Gateway Bridge, QLD Baltimore City Hall Dome, MD Mandurah Bridge, WA Baltimore Center Stage, MD Victoria Bridge, QLD Northbridge Tunnel, WA Portland City Hall, ME Story Bridge, QLD Joondalup Drive Bridge, WA Troy City Hall, MI King George Square, QLD Crown Metropol Perth, WA I-35W Saint Anthony Falls Bridge, MN Mount Coot-tha Observatory, QLD Perth Convention and Exhibition Centre, WA Sperry Tower, MN Brisbane Town Hall, QLD Lowry Avenue Bridge, MN Brisbane Treasury Casino, QLD France Ave, MN Brisbane Convention & Exhibition Centre, CANADA Forrest Roots Bar, Grill & Bottle Shop, MO QLD Niagara Falls Strawberry's Mid-Town Recreation Inc., Victoria Park, QLD CN Tower MO Broadbeach Sign, QLD High Level Bridge James S. McDonnell Planetarium, MO Surfers Paradise Sign, QLD RBC Convention Centre Charlotte's NASCAR Hall of Fame, NC Munro Martin Parklands, QLD BC Place Romare Bearden Park, NC Port Moody City Hall The Reef Hotel Casino, QLD Wells Fargo Duke Energy Center, NC Calgary Tower Mackay Council Chambers, QLD Alerus Center, ND Halifax City Hall Rockhampton Riverbank Heritage Façade, Bob Kerrey Pedestrian Bridge, NE Science World Dome Las Vegas City Hall, NV QLD Mid-Hudson Bridge, NY Victoria Street Bridge, QLD The Helmsley Building, NY City Hall Annex, QLD CHILE Tower280, NY Strand Fountain, QLD IEB, University of Chile Legacy Tower, NY Queensland Country Bank Stadium, QLD CABO Building The Penthouse at One East Avenue, NY SkyPoint Observation Deck, QLD The Metropolitan, NY Reddacliff Place sculptures, QLD 3 City Center, NY Townsville Sign, QLD IRELAND Rochester Riverside Convention Center, NY Adelaide Festival Centre, SA Limerick City and County Council Offices Xerox Tower, NY Adelaide Town Hall, SA Mansion House The Electric Tower, NY SA Power Networks Building, SA Tuckahoe Village Hall, NY Riverbank Footbridge, SA Pier 17, NY City of Launceston Town Hall, TAS NEW ZEALAND Library Tower, NY paranaple convention centre, TAS Oamaru Opera House Yonkers City Hall Clock Tower, NY Cardinal Lights, TAS Michael Fowler Centre Terminal Tower, OH University East Building, OH Railway Roundabout Fountain, TAS Skydance Bridge, OK Kennedy Lane, TAS United Kingdom Elizabeth Mall, TAS Union Street Railroad Bridge, OR The Ness Bridge Wrest Point Casino, TAS Philadelphia's Cira Centre, PA Edinburgh - Camera Obscura Philadelphia's One & Two Liberty Place, PA FRAXA Ambassador Kelly Menke Randels Coleman pictured above with her son, Cody Randels who has Fragile X and her late father, John Menke, prior to his passing from FXTAS. OUR IMPACT TO DATE In 1994, parents Katie Clapp, Michael Tranfaglia, MD, and Kathy May founded FRAXA Research Foundation committed to finding a cure for Fragile X. Since that time, FRAXA has become the global leader for funding the cure.

FRAXA has funded more than $30 million in biomedical research globally, yielding discoveries that are changing the lives of families coping with Fragile X.

Learn more about our impact at fraxa.org. $30,692,922 612 19 Direct Investment in Research Grants Countries are Home Fragile X Research Awarded to Research Teams 5 31 4 Ongoing Fragile X Pharmaceutical and Gene Therapy and Clinical Trials and Biomedical Protein Replacement Studies Partners Studies