Table S5. IRF6 and Related Proteins Have Different Protein Domains

Home , CAMK2B, CAMK2G, CISH, FCGR3A, FOXG1, HCK

Table S5. IRF6 and related proteins have different protein domains

List Pop Pop Fold Term Count % P-Value Genes Bonferroni Benjamini FDR Total Hits Total Enrichment

SPSB1, SOCS3, SPSB2, SOCS1, ASB12,

SPSB4, ASB11, ASB14, ASB16, ASB15, CISH, IPR001496:SOCS protein, C-terminal 24 0.443705 2.05E-26 479 38 16659 21.9654983 1.37E-23 1.37E-23 3.07E-23 ASB18, ASB17, WSB1, ASB9, ASB8, ASB10,

ASB1, ASB3, ASB2, ASB5, ASB4, ASB7, ASB6

PVR, CD8A, NFKB1, NFKB2, HLA-DMB,

HLA-DMA, PDCD1, TAPBP, CD96, LILRA1,

IL1RAP, FCGR3A, CRTAM, ICAM4, RELA,

RELB, ICAM3, HLA-DQA2, HLA-DQA1,

PDCD1LG2, NCAM1, LILRB2, LILRB5,

ROR2, HLA-DPA1, MADCAM1, CD226,

IPR013783:Immunoglobulin-like fold 57 1.053799 1.16E-16 ICOSLG, KIR3DL1, HLA-DRA, KIR3DL2, 479 553 16659 3.58478521 7.46E-14 3.73E-14 1.67E-13

HLA-DQB1, FGFR2, IL1R2, FGFR1, IL1R1,

HLA-DRB1, HLA-DRB3, KIT, VCAM1, REL,

PVRL1, ICOS, HLA-DRB4, HLA-DRB5,

HLA-DPB1, HLA-DOA, HLA-DOB, CD28,

NFATC1, KIR2DS2, CTLA4, KIR2DS1,

MALT1, AGER, BTLA, FCGR2B, CD274

IRF9, IRF5, IRF6, IRF7, IRF8, SMAD5,

IPR017855:SMAD domain-like 12 0.221852 1.19E-14 SMAD4, SMAD3, IRF3, SMAD2, IRF4, 479 15 16659 27.82296451 7.98E-12 2.66E-12 1.78E-11

SMAD1

IPR019817:Interferon regulatory factor, IRF9, IRF5, IRF6, IRF7, IRF8, IRF1, IRF2, 9 0.166389 3.81E-12 479 9 16659 34.77870564 2.56E-09 6.40E-10 5.71E-09 conserved site IRF3, IRF4

IPR001346:Interferon regulatory factor 9 0.166389 3.81E-12 IRF9, IRF5, IRF6, IRF7, IRF8, IRF1, IRF2, 479 9 16659 34.77870564 2.56E-09 6.40E-10 5.71E-09 IRF3, IRF4

HLA-DQB1, HLA-DRB1, HLA-DRB3,

HLA-DMB, HLA-DMA, HLA-DQA2, IPR014745:MHC class II, alpha/beta 12 0.221852 5.14E-12 HLA-DQA1, HLA-DRB4, HLA-DRB5, 479 22 16659 18.97020307 3.45E-09 6.90E-10 7.71E-09 chain, N-terminal HLA-DPA1, HLA-DPB1, HLA-DOB,

HLA-DRA

IL1R1, TLR10, MYD88, IL1RAP, TLR1, TLR2, IPR000157:Toll-Interleukin receptor 12 0.221852 9.59E-12 479 23 16659 18.14541164 6.45E-09 1.07E-09 1.44E-08 TLR3, TLR4, TLR5, TLR7, TLR8, TLR9

HLA-DQB1, PVR, FGFR2, FGFR1, IL1R2,

IL1R1, HLA-DRB1, CD8A, HLA-DRB3, KIT,

HLA-DMB, HLA-DMA, PDCD1, TAPBP,

VCAM1, CD96, LILRA1, PVRL1, IL1RAP,

HLA-DRB4, HLA-DRB5, HLA-DPB1,

IPR007110:Immunoglobulin-like 45 0.831947 4.12E-11 FCGR3A, HLA-DOA, HLA-DOB, CRTAM, 479 501 16659 3.123835836 2.77E-08 3.95E-09 6.17E-08

ICAM3, MALT1, HLA-DQA2, AGER,

HLA-DQA1, PDCD1LG2, BTLA, NCAM1,

LILRB2, CD19, LILRB5, FCGR2B, CD274,

ROR2, HLA-DPA1, MADCAM1, CD226,

CD200, ICOSLG, HLA-DRA

TRAF2, DZIP3, PML, TRIM11, RNF125,

RNF123, MGRN1, TRIM9, RBCK1, RCHY1,

TRAF6, TRAF3, RNF144B, LRSAM1, RNF220, IPR017907:Zinc finger, RING-type, 32 0.591607 1.27E-10 DTX3L, CBL, UBR2, UBR1, UBOX5, PARK2, 479 280 16659 3.974709216 8.55E-08 1.07E-08 1.91E-07 conserved site TRIM63, TRIM21, PJA2, TRIM37, PJA1,

CBLB, TRIM36, TRIM32, RNF25, RNF111,

RNF41 HLA-DQB1, HLA-DRB1, HLA-DRB3,

HLA-DMB, HLA-DQA2, HLA-DMA, AGER, IPR003006:Immunoglobulin/major 18 0.332779 3.55E-10 HLA-DQA1, TAPBP, RAET1E, TPP2, ULBP2, 479 87 16659 7.19559427 2.38E-07 2.65E-08 5.32E-07 histocompatibility complex, conserved site HLA-DRB4, HLA-DRB5, HLA-DPA1,

HLA-DPB1, HLA-DOA, HLA-DOB, HLA-DRA

IRAK2, BCL10, NFKB1, NFKB2, AIM2,

NLRP1, IRAK3, TNFRSF1A, MYD88, IPR011029:DEATH-like 16 0.295803 5.20E-10 479 67 16659 8.30536254 3.49E-07 3.49E-08 7.80E-07 TNFRSF10B, MEFV, RIPK1, PYCARD, RIPK2,

NGFR, FAS

IPR019471:Interferon regulatory factor-3 7 0.129414 3.70E-09 IRF9, IRF5, IRF6, IRF7, IRF8, IRF3, IRF4 479 7 16659 34.77870564 2.48E-06 2.26E-07 5.54E-06

CSH1, IL3, CSF2, IL6, CSH2, IL5, KITLG, IPR012351:Four-helical cytokine, core 13 0.24034 4.35E-09 479 46 16659 9.828764636 2.93E-06 2.44E-07 6.53E-06 IL10, GH2, GH1, IFNG, PRL, IL2

RNASEL, NFKBIE, NFKBIB, ASB12, ASB11,

NFKBIA, ASB14, NFKB1, NFKB2, ASB16,

IPR002110:Ankyrin 27 0.499168 5.41E-09 ASB15, ASB18, ASB17, CDKN2A, ASB10, 479 238 16659 3.945483413 3.64E-06 2.80E-07 8.12E-06

ILK, NFKBIZ, ASB9, ASB8, NOTCH1, ASB1,

ASB3, ASB2, ASB5, ASB4, ASB7, ASB6

UBE2A, UBE2Z, UBE2G2, UBE2J1, UBE2J2, IPR016135:Ubiquitin-conjugating 13 0.24034 7.40E-09 CDC34, UBE2Q1, UBE2B, UBE2R2, UBE2N, 479 48 16659 9.419232777 4.97E-06 3.55E-07 1.11E-05 enzyme/RWD-like UBE2O, RNF25, UBE2E2

TRAF2, DZIP3, PML, TRIM11, RNF125,

RNF123, MGRN1, TRIM9, RBCK1, RCHY1,

TRAF6, TRAF3, RNF144B, LRSAM1, RNF220, IPR001841:Zinc finger, RING-type 30 0.554631 8.66E-09 479 296 16659 3.524868815 5.82E-06 3.88E-07 1.30E-05 DTX3L, CBL, UBR2, UBOX5, TRIM63,

TRIM21, PJA2, TRIM37, PJA1, CBLB,

TRIM36, TRIM32, RNF25, RNF111, RNF41 UBE2N, UBE2O, UBE2A, UBE2Z, UBE2G2, IPR000608:Ubiquitin-conjugating enzyme, 12 0.221852 1.40E-08 UBE2J1, CDC34, UBE2J2, UBE2B, UBE2Q1, 479 41 16659 10.17913336 9.44E-06 5.90E-07 2.11E-05 E2 UBE2E2, UBE2R2

IRAK2, TNFRSF1A, IRAK1, IRAK3,

IPR000488:Death 11 0.203365 2.43E-08 TNFRSF10B, MYD88, RIPK1, NFKB1, 479 34 16659 11.25193418 1.64E-05 9.62E-07 3.65E-05

NFKB2, FAS, NGFR

HLA-DQB1, HLA-DRB1, HLA-DRB3,

HLA-DMB, HLA-DMA, HLA-DQA2,

IPR003597:Immunoglobulin C1-set 14 0.258828 5.65E-08 HLA-DQA1, TAPBP, HLA-DRB4, HLA-DRB5, 479 68 16659 7.160321749 3.80E-05 2.11E-06 8.47E-05

HLA-DPA1, HLA-DPB1, HLA-DOA,

HLA-DOB, HLA-DRA

PVR, FGFR2, IL1R2, FGFR1, IL1R1, ICAM3,

KIR2DS2, KIR2DS1, MALT1, KIT, AGER,

IPR013151:Immunoglobulin 23 0.425217 8.68E-08 NCAM1, VCAM1, LILRB2, LILRA1, LILRB5, 479 202 16659 3.959951632 5.83E-05 3.07E-06 1.30E-04

PVRL1, FCGR2B, CD274, FCGR3A, CD200,

KIR3DL1, KIR3DL2

PTPN6, INPPL1, SOCS3, HCK, STAT5B,

IPR000980:SH2 motif 17 0.314291 1.09E-07 SOCS1, STAT1, CISH, STAT3, STAT2, CBLB, 479 111 16659 5.326468431 7.35E-05 3.68E-06 1.64E-04

CRKL, SH2B1, INPP5D, JAK3, SYK, BLNK

IL1R2, IL1R1, CD8A, KIT, VCAM1, CD96,

LILRA1, PVRL1, IL1RAP, FCGR3A, CRTAM,

ICAM3, CD160, KIR2DS2, KIR2DS1, MALT1, IPR003599:Immunoglobulin subtype 29 0.536143 3.28E-07 479 330 16659 3.056310495 2.20E-04 1.05E-05 4.92E-04 AGER, PDCD1LG2, BTLA, LILRB2, CD19,

FCGR2B, LILRB5, CD274, MADCAM1,

CD200, KIR3DL1, ICOSLG, KIR3DL2

IPR018957:Zinc finger, C3HC4 23 0.425217 7.17E-07 TRAF2, DZIP3, DTX3L, PML, TRIM63, 479 228 16659 3.5083782 4.82E-04 2.19E-05 0.001076 RING-type TRIM21, TRIM11, PJA2, RNF125, PJA1,

CBLB, RNF123, TRIM36, MGRN1, TRIM9,

TRIM32, RNF25, RBCK1, RCHY1, TRAF6,

RNF41, RNF111, TRAF3

E2F1, FOXA2, PAX6, PAX3, FOXP3, CUL3,

IPR011991:Winged helix repressor IRF9, PAX9, IRF5, IRF6, IRF7, IRF8, FOXG1, 20 0.369754 1.90E-06 479 187 16659 3.719647662 0.001279295 5.57E-05 0.002857 DNA-binding IRF1, IRF2, IRF3, RAPGEF4, RAPGEF3, IRF4,

ADAR

TNFRSF1A, TNFRSF1B, TNFRSF11A, IPR001368:TNFR/CD27/30/40/95 9 0.166389 3.20E-06 TNFRSF10B, TNFRSF12A, TNFRSF10D, FAS, 479 33 16659 9.485101537 0.002147118 8.96E-05 0.004797 cysteine-rich region NGFR, CD40

IPR011539:Rel homology 6 0.110926 4.26E-06 REL, RELA, RELB, NFKB1, NFKB2, NFATC1 479 10 16659 20.86722338 0.002859209 1.15E-04 0.00639

IPR000451:NF-kappa-B/Rel/dorsal 6 0.110926 4.26E-06 REL, RELA, RELB, NFKB1, NFKB2, NFATC1 479 10 16659 20.86722338 0.002859209 1.15E-04 0.00639

HLA-DQB1, HLA-DRB1, HLA-DRB3, IPR000353:MHC class II, beta chain, 7 0.129414 5.11E-06 HLA-DRB4, HLA-DRB5, HLA-DPB1, 479 17 16659 14.3206435 0.003430664 1.32E-04 0.00767 N-terminal HLA-DMB, HLA-DOB

EGFR, FGFR2, FGFR1, HCK, ERBB2, KIT,

IPR001245:Tyrosine protein kinase 15 0.277316 7.23E-06 IRAK4, MAP3K7, IGF1R, PTK2B, RIPK1, ILK, 479 118 16659 4.421021903 0.00484952 1.80E-04 0.010849

ROR2, JAK3, SYK

FGFR2, FGFR1, RNASEL, STK11, TBK1,

ERBB2, CAMK2G, KIT, PRKG1, MAP3K7,

IRAK4, IGF1R, IRAK3, MAP3K3, PTK2B,

IPR000719:Protein kinase, core 33 0.610094 7.74E-06 ILK, CAMK2D, CAMK2B, CAMK2A, CHUK, 479 476 16659 2.411128752 0.005188681 1.86E-04 0.01161

SYK, IRAK2, EGFR, IRAK1, HCK, IKBKE,

RIPK1, RIPK2, ROR2, JAK3, IKBKB,

MAP3K14, EIF2AK2 FGFR2, FGFR1, RNASEL, STK11, TBK1,

ERBB2, CAMK2G, KIT, PRKG1, MAP3K7,

IRAK4, IGF1R, IRAK3, MAP3K3, PTK2B, IPR017441:Protein kinase, ATP binding 32 0.591607 8.27E-06 ILK, CAMK2D, CAMK2B, CAMK2A, CHUK, 479 455 16659 2.445974902 0.0055419 1.92E-04 0.012402 site SYK, IRAK2, EGFR, IRAK1, HCK, IKBKE,

RIPK2, ROR2, JAK3, MAP3K14, EIF2AK2,

IKBKB

IPR001400:Somatotropin hormone 5 0.092439 9.59E-06 CSH1, GH2, GH1, CSH2, PRL 479 6 16659 28.9822547 0.006425042 2.15E-04 0.014385

IPR007397:F-box associated region 5 0.092439 9.59E-06 FBXO17, FBXO27, FBXO2, FBXO6, FBXO44 479 6 16659 28.9822547 0.006425042 2.15E-04 0.014385

IPR001003:MHC class II, alpha chain, HLA-DPA1, HLA-DOA, HLA-DQA2, 6 0.110926 1.28E-05 479 12 16659 17.38935282 0.008542846 2.77E-04 0.019147 N-terminal HLA-DMA, HLA-DQA1, HLA-DRA

BCL10, CARD11, IFIH1, NOD1, CARD9, IPR001315:Caspase Recruitment 8 0.147902 1.38E-05 479 29 16659 9.594125693 0.009247237 2.90E-04 0.020733 PYCARD, RIPK2, NLRP1

IPR003191:Guanylate-binding protein, 5 0.092439 2.19E-05 GBP7, GBP5, GBP4, GBP3, GBP2 479 7 16659 24.8419326 0.014590929 4.45E-04 0.0328 C-terminal

IPR018116:Somatotropin hormone, 5 0.092439 2.19E-05 CSH1, GH2, GH1, CSH2, PRL 479 7 16659 24.8419326 0.014590929 4.45E-04 0.0328 conserved site

IPR013790:Dwarfin 5 0.092439 4.28E-05 SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 479 8 16659 21.73669102 0.028320927 8.45E-04 0.064101

IPR001132:SMAD domain, Dwarfin-type 5 0.092439 4.28E-05 SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 479 8 16659 21.73669102 0.028320927 8.45E-04 0.064101

IPR013019:MAD homology, MH1 5 0.092439 4.28E-05 SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 479 8 16659 21.73669102 0.028320927 8.45E-04 0.064101

IPR015742:Calcium/calmodulin-dependent 4 0.073951 9.19E-05 CAMK2G, CAMK2D, CAMK2B, CAMK2A 479 4 16659 34.77870564 0.059896437 0.001763165 0.137757 protein kinase II isoform

IPR013543:Calcium/calmodulin dependent 4 0.073951 9.19E-05 CAMK2G, CAMK2D, CAMK2B, CAMK2A 479 4 16659 34.77870564 0.059896437 0.001763165 0.137757 protein kinase II, association-domain

IPR015894:Guanylate-binding protein, 5 0.092439 1.88E-04 GBP7, GBP5, GBP4, GBP3, GBP2 479 11 16659 15.80850256 0.118780311 0.003506292 0.281819 N-terminal IPR002366:Defensin propeptide 4 0.073951 2.25E-04 DEFA1B, DEFA5, DEFA4, DEFA3, DEFA1 479 5 16659 27.82296451 0.140259862 0.004076132 0.336724

IPR017241:Toll-like receptor 4 0.073951 2.25E-04 TLR10, TLR1, TLR2, TLR4 479 5 16659 27.82296451 0.140259862 0.004076132 0.336724

IPR016327:Alpha-defensin 4 0.073951 2.25E-04 DEFA1B, DEFA5, DEFA4, DEFA3, DEFA1 479 5 16659 27.82296451 0.140259862 0.004076132 0.336724

IPR006081:Alpha defensin 4 0.073951 2.25E-04 DEFA1B, DEFA5, DEFA4, DEFA3, DEFA1 479 5 16659 27.82296451 0.140259862 0.004076132 0.336724

IPR003619:MAD homology 1, 5 0.092439 2.76E-04 SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 479 12 16659 14.49112735 0.169220168 0.004866815 0.412913 Dwarfin-type

IPR002083:MATH 5 0.092439 2.76E-04 TRAF1, TRIM37, TRAF2, TRAF6, TRAF3 479 12 16659 14.49112735 0.169220168 0.004866815 0.412913

IPR004075:Interleukin-1 receptor, type 5 0.092439 3.89E-04 IL1R1, IL1RAP, TLR1, TLR2, TLR8 479 13 16659 13.37642524 0.230296532 0.006689065 0.58249 I/Toll precursor

IPR012990:Sec23/Sec24 beta-sandwich 4 0.073951 4.40E-04 SEC23A, SEC24B, SEC24C, SEC24D 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093

IPR012227:TNF receptor-associated factor 4 0.073951 4.40E-04 TRAF1, TRAF2, TRAF6, TRAF3 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093 TRAF

IPR006900:Sec23/Sec24 helical region 4 0.073951 4.40E-04 SEC23A, SEC24B, SEC24C, SEC24D 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093

IPR012346:p53 and RUNT-type 4 0.073951 4.40E-04 TP53, TP63, RUNX2, TP73 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093 transcription factor, DNA-binding

IPR006896:Sec23/Sec24 trunk region 4 0.073951 4.40E-04 SEC23A, SEC24B, SEC24C, SEC24D 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093

IPR006895:Zinc finger, Sec23/Sec24-type 4 0.073951 4.40E-04 SEC23A, SEC24B, SEC24C, SEC24D 479 6 16659 23.18580376 0.256090272 0.007368607 0.658093

IPR008266:Tyrosine protein kinase, active EGFR, FGFR2, IGF1R, FGFR1, PTK2B, 11 0.203365 4.65E-04 479 97 16659 3.943976928 0.268385202 0.007593005 0.695037 site ERBB2, HCK, ROR2, JAK3, KIT, SYK

IPR013799:STAT transcription factor, 4 0.073951 7.54E-04 STAT5B, STAT1, STAT3, STAT2 479 7 16659 19.87354608 0.397559076 0.011993349 1.124665 protein interaction

IPR001217:STAT transcription factor, core 4 0.073951 7.54E-04 STAT5B, STAT1, STAT3, STAT2 479 7 16659 19.87354608 0.397559076 0.011993349 1.124665

IPR012345:STAT transcription factor, 4 0.073951 7.54E-04 STAT5B, STAT1, STAT3, STAT2 479 7 16659 19.87354608 0.397559076 0.011993349 1.124665 DNA-binding, subdomain

IPR013801:STAT transcription factor, 4 0.073951 7.54E-04 STAT5B, STAT1, STAT3, STAT2 479 7 16659 19.87354608 0.397559076 0.011993349 1.124665 DNA-binding IPR013800:STAT transcription factor, 4 0.073951 7.54E-04 STAT5B, STAT1, STAT3, STAT2 479 7 16659 19.87354608 0.397559076 0.011993349 1.124665 all-alpha

RNF123, TRIM36, MEFV, SPSB1, TRIM9, IPR001870:B302 (SPRY)-like 10 0.184877 8.64E-04 479 87 16659 3.997552372 0.44044136 0.013411738 1.287482 SPSB2, RYR1, SPSB4, TRIM21, TRIM11

IL7R, IFNAR1, NCAM1, IGF1R, IFNAR2,

IPR008957:Fibronectin, type III-like fold 15 0.277316 8.77E-04 TRIM36, PRLR, TRIM9, IL2RG, IL5RA, 479 184 16659 2.835220568 0.445464633 0.013311173 1.307347

IFNGR2, CSF2RA, IFNGR1, IL3RA, GHR

IPR018355:SPla/RYanodine receptor RNF123, MEFV, SPSB1, SPSB2, RYR1, SPSB4, 8 0.147902 9.45E-04 479 55 16659 5.05872082 0.470278629 0.014020871 1.408134 subgroup TRIM21, TRIM11

TRIM37, TRIM36, MEFV, TRIM9, TRIM32, IPR000315:Zinc finger, B-box 9 0.166389 0.001037302 479 72 16659 4.347338205 0.502136208 0.015047138 1.544522 PML, TRIM63, TRIM21, TRIM11

UBE3B, NEDD4, HECTD3, NEDD4L, UBE3C, IPR000569:HECT 6 0.110926 0.001083989 479 28 16659 7.452579779 0.51752954 0.015387523 1.613511 TRIP12

IPR006080:Mammalian defensin 4 0.073951 0.001180479 DEFA1B, DEFA5, DEFA4, DEFA3, DEFA1 479 8 16659 17.38935282 0.54785419 0.016400493 1.755952

IPR006052:Tumor Necrosis Factor 5 0.092439 0.001183304 TNFSF11, TNF, CD40LG, TNFSF12, EDA 479 17 16659 10.22903107 0.548712656 0.016106654 1.760119

IPR001628:Zinc finger, nuclear hormone VDR, RARG, THRA, NR1D1, RXRA, RARA, 7 0.129414 0.001914016 479 46 16659 5.292411727 0.724026716 0.025420345 2.832539 receptor-type ESR2

VDR, RARG, THRA, NR1D1, RXRA, RARA, IPR001723:Steroid hormone receptor 7 0.129414 0.002141917 479 47 16659 5.179807222 0.763288216 0.027857787 3.164774 ESR2

IPR013162:CD80-like, immunoglobulin PVR, CRTAM, PVRL1, CD274, AGER, 6 0.110926 0.002327086 479 33 16659 6.323401025 0.791042425 0.029659419 3.433932 C2-set PDCD1LG2

IPR000536:Nuclear hormone receptor, VDR, RARG, THRA, NR1D1, RXRA, RARA, 7 0.129414 0.002389703 479 48 16659 5.071894572 0.799672601 0.029880376 3.524793 ligand-binding, core ESR2

IPR008946:Nuclear hormone receptor, VDR, RARG, THRA, NR1D1, RXRA, RARA, 7 0.129414 0.002389703 479 48 16659 5.071894572 0.799672601 0.029880376 3.524793 ligand-binding ESR2

IPR010991:p53, tetramerisation 3 0.055463 0.002417921 TP53, TP63, TP73 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713 IPR003175:Cyclin-dependent kinase 3 0.055463 0.002417921 CDKN1C, CDKN1A, CDKN1B 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713 inhibitor

IPR015551:Cellular tumour antigen p53 3 0.055463 0.002417921 TP53, TP63, TP73 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713

IPR011615:p53, DNA-binding 3 0.055463 0.002417921 TP53, TP63, TP73 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713

IPR002117:p53 tumour antigen 3 0.055463 0.002417921 TP53, TP63, TP73 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713

IPR003911:Transforming growth factor 3 0.055463 0.002417921 TGFB3, TGFB1, TGFB2 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713 beta TGFb

IPR016319:Transforming growth 3 0.055463 0.002417921 TGFB3, TGFB1, TGFB2 479 3 16659 34.77870564 0.803444535 0.029676854 3.565713 factor-beta

IPR000594:UBA/THIF-type NAD/FAD 4 0.073951 0.002423376 UBA1, ATG7, UBA3, UBA6 479 10 16659 13.91148225 0.804165505 0.029210081 3.573622 binding fold

IPR000975:Interleukin-1 4 0.073951 0.002423376 IL18, IL1RN, IL1B, IL1A 479 10 16659 13.91148225 0.804165505 0.029210081 3.573622

IPR002909:Cell surface receptor IPT/TIG 6 0.110926 0.002664983 REL, RELA, RELB, NFKB1, NFKB2, NFATC1 479 34 16659 6.137418642 0.833583054 0.03151519 3.923294

IPR001111:Transforming growth factor 5 0.092439 0.002717285 BMP4, BMP2, TGFB3, TGFB1, TGFB2 479 21 16659 8.280644199 0.839345733 0.031569887 3.998833 beta (TGFb), N-terminal

IPR003877:SPla/RYanodine receptor RNF123, MEFV, SPSB1, TRIM9, SPSB2, 9 0.166389 0.00280449 479 84 16659 3.72628989 0.848514458 0.032015354 4.124661 SPRY RYR1, SPSB4, TRIM21, TRIM11

IRAK2, IRAK1, STK11, TBK1, CAMK2G,

PRKG1, IRAK4, MAP3K7, IKBKE, IRAK3, IPR008271:Serine/threonine protein 21 0.388242 0.003225954 MAP3K3, RIPK1, ILK, CAMK2D, RIPK2, 479 354 16659 2.063143555 0.885975901 0.036133486 4.730618 kinase, active site CAMK2B, EIF2AK2, MAP3K14, IKBKB,

CAMK2A, CHUK

IPR007111:NACHT nucleoside 5 0.092439 0.003842342 CIITA, NLRC5, NOD1, NLRX1, NLRP1 479 23 16659 7.560588182 0.924756622 0.042200797 5.610393 triphosphatase

FBXW7, FBXW8, FBXO17, FBXO27, FBXO2, IPR001810:Cyclin-like F-box 8 0.147902 0.003866279 479 70 16659 3.974709216 0.925961887 0.041777242 5.644405 FBXO6, FBXO44, FBXO4 IPR001293:Zinc finger, TRAF-type 4 0.073951 0.004256835 TRAF2, XAF1, TRAF6, TRAF3 479 12 16659 11.59290188 0.943113607 0.045184435 6.19773

IPR013322:TRAF-type 4 0.073951 0.004256835 TRAF1, TRAF2, TRAF6, TRAF3 479 12 16659 11.59290188 0.943113607 0.045184435 6.19773

IPR018952:2'-5'-oligoadenylate synthetase 3 0.055463 0.004743934 OASL, OAS3, OAS2 479 4 16659 26.08402923 0.959054338 0.049457468 6.883591 1, domain 2/C-terminal

IPR006117:2-5-oligoadenylate synthetase, 3 0.055463 0.004743934 OASL, OAS3, OAS2 479 4 16659 26.08402923 0.959054338 0.049457468 6.883591 conserved site

IPR007123:Gelsolin region 4 0.073951 0.006749099 SEC23A, SEC24B, SEC24C, SEC24D 479 14 16659 9.936773039 0.989440914 0.068636613 9.657976

IPR018074:Ubiquitin-activating enzyme, 3 0.055463 0.007756648 UBA1, UBA3, UBA6 479 5 16659 20.86722338 0.994661381 0.077349189 11.02273 E1, active site

IPR006116:2-5-oligoadenylate synthetase, 3 0.055463 0.007756648 OASL, OAS3, OAS2 479 5 16659 20.86722338 0.994661381 0.077349189 11.02273 ubiquitin-like region

IPR000127:Ubiquitin-activating enzyme 3 0.055463 0.007756648 UBA1, UBA3, UBA6 479 5 16659 20.86722338 0.994661381 0.077349189 11.02273 repeat

IPR003532:Short hematopoietin receptor, 3 0.055463 0.007756648 IL5RA, CSF2RA, IL3RA 479 5 16659 20.86722338 0.994661381 0.077349189 11.02273 family 2, conserved site

IRAK2, IRAK1, STK11, TBK1, CAMK2G,

PRKG1, MAP3K7, IRAK4, IKBKE, IRAK3, IPR017442:Serine/threonine protein 20 0.369754 0.00789361 MAP3K3, RIPK1, CAMK2D, RIPK2, 479 359 16659 1.937532347 0.995134338 0.077520558 11.20676 kinase-related CAMK2B, EIF2AK2, MAP3K14, IKBKB,

CAMK2A, CHUK

CIITA, TLR10, LRSAM1, TLR1, TLR2, TLR3,

IPR001611:Leucine-rich repeat 14 0.258828 0.008622236 TLR4, TLR5, TLR7, TLR8, NLRP1, TLR9, 479 213 16659 2.285924314 0.997030216 0.083189717 12.17981

NLRC5, CD14

IPR003987:Intercellular adhesion molecule/vascular cell adhesion molecule, 3 0.055463 0.011414905 VCAM1, ICAM4, ICAM3 479 6 16659 17.38935282 0.999553885 0.107255538 15.81788

N-terminal IPR004074:Interleukin-1 receptor, type I 3 0.055463 0.011414905 IL1R2, IL1R1, IL1RAP 479 6 16659 17.38935282 0.999553885 0.107255538 15.81788 and type II

IPR015615:Transforming growth 5 0.092439 0.012742527 BMP4, BMP2, TGFB3, TGFB1, TGFB2 479 32 16659 5.434172756 0.999819179 0.1174136 17.49762 factor-beta-related

IPR000483:Cysteine-rich flanking region, TLR10, TLR1, TLR2, TLR3, TLR4, TLR5, 8 0.147902 0.013222342 479 88 16659 3.161700512 0.999869571 0.119954038 18.09696 C-terminal TLR7, TLR8

IPR013088:Zinc finger, NHR/GATA-type 6 0.110926 0.015135489 VDR, RARG, THRA, NR1D1, GATA3, ESR2 479 51 16659 4.091612428 0.9999646 0.134414728 20.44651

IPR006211:Furin-like cysteine rich region 3 0.055463 0.015679334 EGFR, IGF1R, ERBB2 479 7 16659 14.90515956 0.999975577 0.137137431 21.10283

IPR000494:EGF receptor, L domain 3 0.055463 0.015679334 EGFR, IGF1R, ERBB2 479 7 16659 14.90515956 0.999975577 0.137137431 21.10283

IPR003126:Zinc finger, N-recognin 3 0.055463 0.015679334 UBR4, UBR2, UBR1 479 7 16659 14.90515956 0.999975577 0.137137431 21.10283

MRC1, KLRG1, CD207, CD44, MRC2, KLRK1, IPR016186:C-type lectin-like 8 0.147902 0.019438416 479 95 16659 2.928733106 0.999998133 0.16531591 25.50305 KLRD1, KLRC1

IPR017948:Transforming growth factor 5 0.092439 0.020930336 BMP4, BMP2, TGFB3, TGFB1, TGFB2 479 37 16659 4.699825086 0.999999329 0.174765257 27.18506 beta, conserved site

IPR001839:Transforming growth factor 5 0.092439 0.020930336 BMP4, BMP2, TGFB3, TGFB1, TGFB2 479 37 16659 4.699825086 0.999999329 0.174765257 27.18506 beta

KLHL9, KLHL13, KLHL21, KEAP1, GAN, IPR011705:BTB/Kelch-associated 6 0.110926 0.021926774 479 56 16659 3.72628989 0.999999661 0.180163061 28.28865 KLHL20

IPR004020:Pyrin 4 0.073951 0.024107629 MEFV, PYCARD, AIM2, NLRP1 479 22 16659 6.323401025 0.999999924 0.194082312 30.64976

IPR001523:Paired box protein, N-terminal 3 0.055463 0.025877763 PAX9, PAX6, PAX3 479 9 16659 11.59290188 0.999999978 0.204524998 32.51265

IPR000651:Guanine nucleotide exchange 4 0.073951 0.027147422 RASGRP1, RAPGEF4, RAPGEF3, RAPGEF1 479 23 16659 6.048470546 0.999999991 0.211102459 33.81996 factor for Ras-like GTPases, N-terminal

IPR017096:Kelch-like protein, gigaxonin 5 0.092439 0.029364011 KLHL9, KLHL13, KEAP1, GAN, KLHL20 479 41 16659 4.241305565 0.999999998 0.223936262 36.04579

MRC1, KLRG1, CD207, MRC2, KLRK1, IPR001304:C-type lectin 7 0.129414 0.030362482 479 82 16659 2.968913896 0.999999999 0.228174619 37.02542 KLRD1, KLRC1

IPR018378:C-type lectin, conserved site 7 0.129414 0.030362482 MRC1, KLRG1, CD207, MRC2, KLRK1, 479 82 16659 2.968913896 0.999999999 0.228174619 37.02542 KLRD1, KLRC1

IPR002348:Interleukin 1/heparin-binding 4 0.073951 0.030381659 FGF8, FGF9, IL1B, FGF10 479 24 16659 5.796450939 0.999999999 0.225829803 37.04409 growth factor

IPR008937:Ras guanine nucleotide 4 0.073951 0.03742834 RASGRP1, RAPGEF4, RAPGEF3, RAPGEF1 479 26 16659 5.350570098 1 0.268470246 43.56794 exchange factor

IPR000331:Rap/ran-GAP 3 0.055463 0.038070199 RAP1GAP, SIPA1, RAP1GAP2 479 11 16659 9.485101537 1 0.269664681 44.12969

IPR008983:Tumour necrosis factor-like 5 0.092439 0.039544345 TNFSF11, TNF, CD40LG, TNFSF12, EDA 479 45 16659 3.864300626 1 0.275866657 45.40016

IPR019804:Ras guanine-nucleotide 4 0.073951 0.041237139 RASGRP1, RAPGEF4, RAPGEF3, RAPGEF1 479 27 16659 5.152400835 1 0.283178672 46.8258 exchange factor, conserved site

IPR001930:Peptidase M1, membrane 3 0.055463 0.044832871 LNPEP, ERAP1, ERAP2 479 12 16659 8.694676409 1 0.301218966 49.73954 alanine aminopeptidase

IPR015621:Interleukin-1 receptor 3 0.055463 0.044832871 IL1R2, IL1R1, IL1RAP 479 12 16659 8.694676409 1 0.301218966 49.73954

IPR017903:COS domain 3 0.055463 0.044832871 TRIM36, TRIM9, TRIM63 479 12 16659 8.694676409 1 0.301218966 49.73954

NCAM1, IGF1R, TRIM36, PRLR, TRIM9,

IPR003961:Fibronectin, type III 11 0.203365 0.047730711 IL2RG, IL7R, IFNGR2, CSF2RA, IFNAR1, 479 190 16659 2.013504011 1 0.31461026 51.97859

GHR

KLHL9, KLHL13, KLHL21, KEAP1, GAN, IPR006652:Kelch repeat type 1 6 0.110926 0.047889479 479 69 16659 3.024235273 1 0.312537579 52.09853 KLHL20

IPR014782:Peptidase M1, membrane 3 0.055463 0.051999383 LNPEP, ERAP1, ERAP2 479 13 16659 8.025855147 1 0.331822186 55.10778 alanine aminopeptidase, N-terminal

IPR001895:Guanine-nucleotide 4 0.073951 0.053775578 RASGRP1, RAPGEF4, RAPGEF3, RAPGEF1 479 30 16659 4.637160752 1 0.338154923 56.35288 dissociation stimulator CDC25

IPR005293:Antigen peptide transporter 2 2 0.036975 0.056564771 TAP2, TAP1 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR000197:Zinc finger, TAZ-type 2 0.036975 0.056564771 EP300, CREBBP 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR014744:Nuclear receptor coactivator, 2 0.036975 0.056564771 EP300, CREBBP 479 2 16659 34.77870564 1 0.349483218 58.24323 CREB-bp-like, interlocking IPR003101:Coactivator CBP, KIX 2 0.036975 0.056564771 EP300, CREBBP 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR017431:Interferon regulatory factor-1/2 2 0.036975 0.056564771 IRF1, IRF2 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR003502:Interleukin-1 propeptide 2 0.036975 0.056564771 IL1B, IL1A 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR003769:Adaptor protein ClpS, core 2 0.036975 0.056564771 UBR2, UBR1 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR010303:Protein of unknown function 2 0.036975 0.056564771 EP300, CREBBP 479 2 16659 34.77870564 1 0.349483218 58.24323 DUF902, CREBbp

IPR009255:Transcriptional coactivation 2 0.036975 0.056564771 EP300, CREBBP 479 2 16659 34.77870564 1 0.349483218 58.24323

IPR015681:Nuclear Factor kappaB 2 0.036975 0.056564771 NFKBIB, NFKBIA 479 2 16659 34.77870564 1 0.349483218 58.24323 inhibitor

KLHL9, KLHL13, KLHL21, KEAP1, GAN, IPR013069:BTB/POZ 8 0.147902 0.073283274 479 127 16659 2.190784607 1 0.426452486 68.06517 ZBTB16, KLHL20, HIC1

KLHL9, KLHL13, KLHL21, KEAP1, GAN, IPR013089:Kelch related 6 0.110926 0.076554255 479 79 16659 2.641420681 1 0.43756886 69.71462 KLHL20

IPR014741:Adaptor protein Cbl, EF 2 0.036975 0.083638196 CBLB, CBL 479 3 16659 23.18580376 1 0.46442629 73.01807 hand-like

IPR017386:SOX-12/11/4a 2 0.036975 0.083638196 SOX11, SOX4 479 3 16659 23.18580376 1 0.46442629 73.01807

IPR014719:Ribosomal protein L7/L12, 2 0.036975 0.083638196 UBR2, UBR1 479 3 16659 23.18580376 1 0.46442629 73.01807 C-terminal/adaptor protein ClpS-like

IPR013993:Zinc finger, N-recognin, 2 0.036975 0.083638196 UBR2, UBR1 479 3 16659 23.18580376 1 0.46442629 73.01807 metazoa

IPR003078:Retinoic acid receptor 2 0.036975 0.083638196 RARG, RARA 479 3 16659 23.18580376 1 0.46442629 73.01807

IPR018075:Ubiquitin-activating enzyme, 2 0.036975 0.083638196 UBA1, UBA6 479 3 16659 23.18580376 1 0.46442629 73.01807 E1

IPR003153:Adaptor protein Cbl, 2 0.036975 0.083638196 CBLB, CBL 479 3 16659 23.18580376 1 0.46442629 73.01807 N-terminal helical

IPR014742:Adaptor protein Cbl, SH2-like 2 0.036975 0.083638196 CBLB, CBL 479 3 16659 23.18580376 1 0.46442629 73.01807 IPR003294:Interleukin-1, alpha/beta 2 0.036975 0.083638196 IL1B, IL1A 479 3 16659 23.18580376 1 0.46442629 73.01807

IPR018965:Ubiquitin-activating enzyme 2 0.036975 0.083638196 UBA1, UBA6 479 3 16659 23.18580376 1 0.46442629 73.01807 e1, C-terminal

IPR012852:Coiled-coil transcriptional 2 0.036975 0.083638196 CALCOCO2, TAX1BP1 479 3 16659 23.18580376 1 0.46442629 73.01807 coactivator-like

IPR006212:Furin-like repeat 3 0.055463 0.092931846 EGFR, IGF1R, ERBB2 479 18 16659 5.796450939 1 0.49839926 76.84338