Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8881

Gene expression, histocompatibility Gene rearrangement Reactivation by a trans-acting factor of human major histocompatibility Rearrangement and transcription of a T-cell receptor a-chain gene in complex Ia gene expression in interspecies hybrids between an different T-cell subsets, 531 Ia-negative human B-cell variant and an Ia-positive mouse B-cell Double recombination of a single immunoglobulin K-chain allele: lymphoma, 5145 Implications for the mechanism of rearrangement, 4793 Immunoglobulin gene rearrangements and deletions in human Gene expression, histone Epstein-Barr virus-transformed cell lines producing different IgG and Biphasic pattern of histone gene expression during Drosophila IgA subclasses, 5495 oogenesis, 3316 Organization and sequences of the diversity, joining, and constant region Quantitative and qualitative changes in histone gene expression during genes of the human T-cell receptor P chain, 8624 early mouse embryo development, 5685 Gene regulation Gene expression, mammary One hundred base pairs of 5' flanking sequence of a vaccinia virus late Interaction of mouse mammary epithelial cells with collagen substrata: gene are sufficient to temporally regulate late transcription, 2096 Regulation of casein gene expression and secretion, 1419 Adenovirus infection elevates levels of cellular topoisomerase I, 2247 A dimer of AraC protein contacts three adjacent major groove regions of Gene expression maximization the DNA 3129 Maximizing gene expression from plasmid vectors containing the X PL aral site, promoter: Strategies for overproducing transcription termination factor Gene, regulatory p, 88 Deletions near the albino locus on chromosome 7 of the mouse affect the Gene expression, myoglobin level of tyrosine aminotransferase mRNA, 2866 Cloning, expression in Escherichia col, and reconstitution of human 5681 Gene replacement therapy myoglobin, Glial cells metabolically cooperate: A potential requirement for gene Gene expression, plant replacement therapy, 6662 Expression of genes transferred into monocot and dicot plant cells by electroporation, 5824 Gene, single-copy Efficient cloning of single-copy genes using specialized cosmid vectors: Gene expression, plasmid Isolation of mutant dihydrofolate reductase genes, 1189 Structural and functional organization of the colicin El operon, 8389 Gene structure Gene expression, receptor Complete nucleotide sequences of three VH genes in Caiman, a Interleukin 2 receptor gene expression in normal human T phylogenetically ancient reptile: Evolutionary diversification in coding lymphocytes, 6281 segments and variation in the structure and organization of recombination elements, 844 Gene expression system Structure of a for the human 67-kDa 18% Eukaryotic transient expression system dependent on transcription gene epidermal keratin, 19 Coding sequences for vasoactive intestinal peptide and PHM-27 peptide factors and regulatory DNA sequences of vaccinia virus, are located on two adjacent exons in the human genome, 3548 Gene expression, tissue-specific Complete structure of the aB-crystallin gene: Conservation of the Expression of the a1-proteinase inhibitor gene in human monocytes and exon-intron distribution in the two nonlinked a-crystallin genes, 5819 macrophages, 795 Molecular structure of the human cytoplasmic P-actin gene: Interspecies Independent control elements that determine yolk protein gene homology of sequences in the introns, 6133 expression in alternative Drosophila tissues, 13% Conserved features of eukaryotic hsp7O genes revealed by comparison Differential expression of the mouse cholecystokinin gene during brain with the nucleotide sequence of human hsp70, 6455 5593 and gut development, Gene transfer Gene expression, transferin The presence of a copper/zinc superoxide dismutase in the bacterium Transferrmn gene expression visualized in oligodendrocytes of the rat Photobacterium leiognathi: A likely case of gene transfer from brain by using in situ hybridization and immunohistochemistry, 6706 eukaryotes to prokaryotes, 149 Transfer of genes into hematopoietic cells using recombinant DNA Gene expression, trp viruses, 158 Electron microscopic visualization of trp operon expression in Recombination in mouse L cells between DNA introduced into cells and Salmonella typhimurium, 4638 homologous chromosomal sequences, 1391 Intra- and interspecies transfer and expression of Rhizobium japonicum Gene expression, viral and 3232 a model for gene hydrogen uptake genes autotrophic growth capability, Nucleotide sequence of bean golden mosaic virus and Expression of a second Epstein-Barr virus-determined nuclear antigen in regulation in geminiviruses, 3572 mouse cells after gene transfer with a cloned fragment of the viral Gene expression, yeast genome, 3435 Transposable element sequences involved in the enhancement of yeast Factors affecting the efficiency of introducing foreign DNA into mice by gene expression, 5428 microinjecting eggs, 4438 Efficient insertion of genes into the mouse germ line via retrovial Gene family vectors, 6148 See Multigene family Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector, 8587 Gene family, dispersed Chromosomal assignments of the genes coding for human types II, III, Generation time and IV collagen: A dispersed gene family, 3330 Evidence for higher rates of nucleotide substitution in rodents than in man, 1741 Gene fusion The gene coding for carbamoyl-phosphate synthetase I was formed by Genetic code fusion of an ancestral glutaminase gene and a synthetase gene, 2244 An unusual genetic code in nuclear genes of Tetrahymena, 2452 TnphoA: A transposon probe for protein export signals, 8129 Initiator tRNA may recognize more than the initiation codon in mRNA: A model for translational initiation, 4587 Gene gating Gene gating: A hypothesis, 8527 Genetic drift Expected time for random genetic drift of a population between stable Gene, housekeeping phenotypic states, 7641 Tissue-specific levels of human glucose-6phosphate dehydrogenase Homozygosity, effective number of alleles, and interdeme differentiation correlate with methylation of specific sites at the 3' end of the in subdivided populations, 8611 gene, 1465 Genetic linkage Gene library of in The telomeric region of the human X chromosome long arm: Presence Base composition-independent hybridization tetramethylammonium a highly polymorphic DNA marker and analysis of recombination chloride: A method for oligonucleotide screening of highly complex 2824 gene libraries, 1585 frequency, Gene mapping Genetic restriction Precise localization of genes on large animal virus genomes: Use of Xgtll Suppressor T-cell factor(s) display an altered pattern of Igh and monoclonal antibodies to map the gene for a cytomegalovirus (immunoglobulin heavy chain locus) genetic restriction when developed protein family, 1266 in an Igh-congeneic host, 2133 Assignment of the gene for human DNA polymerase a to the X chromosome, 5270 Genetic risk estimation A highly polymorphic locus in human DNA revealed by cosmid-derived Evidence for linear response for the induction of mutations in human probes, 6206 cells by x-ray exposures below 10 rads, 2092 Gene Genome evolution organlzation murine sarcoma Organization of the human transferrin gene: Direct evidence that it Rates of evolution of the retroviral oncogene of Moloney originated by gene duplication, 3149 virus and of its cellular homologues, 4198 Isolation and characterization of mouse Thy-i genomic clones, 3819 Genome organization Gene probe, synthetic Genes specifying degradation of 3-chlorobenzoic acid in plasmids pAC27 Molecular cloning of the human cholecystokinin gene by use of a and pJP4, 1638 synthetic probe containing deoxyinosine, 1931 Structure and sequence divergence of two archaebacterial genes, 4207 8882 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Genome sructure Cloning and chromosomal location of the a- and 0-globin genes from a Genomic structure of the cottontail rabbit (Shope) papillomavirus, 1580 marsupial, 8105 Gene gating: A hypothesis, 8527 Nonconsensus branch-site sequences in the in vitro splicing of transcripts Geographic Isolation of mutant rabbit 0-globin genes, 8349 Structures of defective P transposable elements prevalent in natural Q y-Globin gene and Q-derived M strains of Drosophila melanogaster, 6236 Nucleotide sequence, evolution, and expression of the fetal globin gene Geographical variation of the spider monkey Ateles geoffroyi, 6985 Homozygosity, effective number of alleles, and interdeme differentiation Globia gene, fetal in subdivided populations, 8611 Adult and fetal human globin genes are expressed following chromosomal Geometry transfer into MEL cells, 780 Pad6 approximations and diophantine geometry, 2212 f-Globin RNA Geometry and topology of isoparametric submanifolds in euclidean Specific regions of the intervening sequences of ,-globin RNA are spaces, 4863 resistant to nuclease in 50S heterogeneous nuclear RNA-protein Gerbil complexes, 8414 Benzodiazepine/y-aminobutyric acid receptor deficit in the midbrain of Globule-bl transformation the seizure-susceptible gerbil, 6701 An unusual bovine pancreatic protein exhibiting pH-dependent Germ-line integration globule-fibril transformation and unique amino acid sequence, 5627 Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection, 6927 a2.,-Globulin gene Developmental and hormonal regulation of a2u-globulin gene Giant axonal neuropathy transcription, 2579 Giant axonal neuropathy: Acceleration of neurofilament transport in optic axons, 920 Glomerulosclerosis Inhibition of thromboxane synthesis ameliorates the progressive kidney Gibberellic acid disease of rats with subtotal renal ablation, 193 Aleurain: A barley thiol protease closely related to mammalian cathepsin H, 6512 Glomerulus Basement membrane heparan sulfate proteoglycans are concentrated in Glass the laminae rarae and in podocytes of the rat renal glomerulus, 3296 A model of protein conformational substates, 3670 Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy, 5963 Glass-like structure Localization of sialic acid in kidney glomeruli: Regionalization in the Protein states and proteinquakes, 5000 podocyte plasma membrane and loss in experimental nephrosis, 8508 gid mutation Glomus cell Immunologic abnormalities of mice bearing the gid mutation suggest a Oxygen chemoreception by carotid body cells in culture, 1448 common pathway for murine nonmalignant lymphoproliferative disorders with autoimmunity, 1219 Glucagon Direct cross-linking of 125I-labeled glucagon to its membrane receptor by Glia UV irradiation, 325 Cytotactin, an extracellular matrix protein of neural and non-neural Correction of hyperglycemia with phloridzin restores the glucagon tissues that mediates glia-neuron interaction, 8075 response to glucose in insulin-deficient dogs: Implications for human Glia-promoting factor diabetes, 1544 Peptides from regenerating central nervous system promote specific Identification of distinct receptor complexes that account for high- and populations of macroglia, 4287 low-affinity glucagon binding to hepatic plasma membranes, 6835 Glial cell (3-Glucan receptor Establishment of a line of human fetal glial cells that supports JC virus Generation of leukotrienes by human monocytes upon stimulation of multiplication, 1257 their P-glucan receptor during phagocytosis, 2751 Glial cells metabolically cooperate: A potential requirement for gene Glucocerebrosidase replacement therapy, 6662 Heterogeneity in type I Gaucher disease demonstrated by restriction Glial fibrillary acidic protein mapping of the gene, 5442 Ontogeny of electncally excitable cells in cultured olfactory Gene mapping and leader polypeptide sequence of human epithelium, 7782 glucocerebrosidase: Implications for Gaucher disease, 7101 Molecular cloning and nucleotide sequence of human glucocerebrosidase Glial growth-promoting factor cDNA, 7289 Purification and characterization of a human T-lymphocyte-derived glial growth-promoting factor, 3930 Glucocorticoid Hormonal response region in the mouse mammary tumor virus long Glioblastoma cell terminal repeat can be dissociated from the proviral promoter and has Synthesis and secretion of proteins resembling platelet-derived growth enhancer properties, 1020 factor by human glioblastoma and fibrosarcoma cells in culture, 2404 Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice, 5880 gin gene Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction Transcription of glnA by purified Escherichia coli components: Core during development and in response to glucocorticoids and RNA polymerase and the products of glnF, gInG, and glnL, 8453 insulin, 8242 glnA gene Glucocorticold-biad lg protein Expression of glnA in Escherichia coli is regulated at tandem Identification of Yb-glutathione-S-transferase as a major rat liver protein promoters, 1979 labeled with dexamethasone 21-methanesulfonate, 7165 Regulation of expression from the glnA promoter of Bacillus subtilis requires the ginA gene product, 3375 Glucocorticold receptor Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria The first intron of the human growth hormone gene contains a binding activate ginA transcription in vitro: Evidence that the ntrA product is a site for glucocorticoid receptor, 699 a factor, 7525 Assignment of the human gene for the glucocorticoid receptor to chromosome 5, 3751 y-Globin Protein kinase activity associated with the purified rat hepatic Common haplotype dependency of high y-tglobin gene expression and glucocorticoid receptor, 4003 high Hb F levels in P-thalassemia and sickle cell anemia patients, 2111 Gluconeogenesis Globin gene RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth Adult and fetal human globin genes are expressed following chromosomal and proper response to nutrient limitation, 3785 transfer into MEL cells, 780 Adrenergic regulation of gluconeogenesis: Possible involvement of two mRNA precursor splicing in vivo: Sequence requirements determined by mechanisms of signal transduction in a1-adrenergic action, 6727 deletion analysis of an intervening sequence, 2885 Gene expression during terminal differentiation: Dexamethasone Glucosamine olosaccharlde suppression of inducer-mediated al- and P"W-globin gene Complete amino acid sequence of human hemopexin, the heme-binding expression, 5020 protein of serum, 73 a-Globin gene Glucose Cloning and chromosomal location of the a- and P-globin genes from a Glucose increases the synthesis of lipoxygenase-mediated metabolites of marsupial, 8105 arachidonic acid in intact rat islets, 198 Correction of hyperglycemia with phloridzin restores the glucagon 3-Globin gene response to glucose in insulin-deficient dogs: Implications for human A method for mapping intranuclear protein-DNA interactions and its diabetes, 1544 application to a nuclease hypersensitive site, 22% High glucose concentrations partially release hexokinase from inhibition A mutation in the ,-globin gene detected in the progeny of a female by glucose 6-phosphate, 1552 mouse treated with ethylnitrosourea, 5829 Protonmotive force-driven active transport of D-glucose and L-proline in The ",-like-globin" gene domain in human erythroid cells, 6384 the protozoan parasite Leishmania donovani, 1716 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8883

Mutations in the phosphoglucose isomerase gene can lead to marked Isolation and characterization of leukotriene C4 synthetase of rat alterations in cellular ATP levels in cultured fibroblasts exposed to basophilic leukemia cells, 8399 simple nutrient shifts, 2761 Glucostatic regulation of (+)-[3H]amphetamine binding in the Glutathione transferase hypothalamus: Correlation with Na4,K4-ATPase activity, 6320 Purification, induction, and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat Glucose cycle chemical hepatocarcinogenesis, 3964 Increased activity of the glucose cycle in the liver: Early characteristic of Identification of Yb-glutathione-S-transferase as a major rat liver protein type 2 diabetes, 2965 labeled with dexamethasone 21-methanesulfonate, 7165 Identification of three classes of cytosolic glutathione transferase Glucose metabolism common to several mammalian species: Correlation between structural Growth hormone and insulin-like growth factors I and II produce distinct data and enzymatic properties, 7202 alterations in glucose metabolism in 3T3-F442A adipocytes, 8724 Glyceraldehyde-3-phosphate dehydrogenase gene Glucose-modified protein Complete sequence of the chicken glyceraldehyde-3-phosphate High-affinity-receptor-mediated uptake and degradation of dehydrogenase gene, 1628 glucose-modified proteins: A potential mechanism for the removal of senescent macromolecules, 5588 Glycine ma High-affinity-receptor-mediated uptake and degradation of DNA sequence and transcript mapping of a soybean gene encoding a glucose-modified proteins: A potential mechanism for the removal of small heat shock protein, 3726 senescent macromolecules (Correction), 8274 Isolation and properties of soybean [Glycine max (L.) Merr.] mutants that nodulate in the presence of high nitrate concentrations, 4162 Glucose 6-phosphate High glucose concentrations partially release hexokinase from inhibition Glycogen by glucose 6-phosphate, 1552 Castanospermine inhibits a-glucosidase activities and alters glycogen Modification of DNA by glucose 6-phosphate induces DNA distribution in animals, 93 rearrangements in an Escherichia coli plasmid, 8439 Prenatal expression of a lethal genetic defect in carbohydrate metabolism in mice, 2101 Glucose-6-phosphate dehydrogenase On ras gene function in yeast, 4740 Tissue-specific levels of human glucose-6phosphate dehydrogenase correlate with methylation of specific sites at the 3' end of the Glycogen storage disease gene, 1465 Characterization of the enzymatic lesion in inherited phosphofructokinase Incomplete X chromosome dosage compensation in chorionic villi of deficiency in the dog: An animal analogue of human glycogen storage human placenta, 3390 disease type VII, 8109 Glucose-6-phosphate dehydrogenase deficiency Glycogen synthase 6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme Epidermal growth factor stimulates glycogen synthase activity in cultured deficiency: Possible interaction with glucose-6phosphate cells, 4563 dehydrogenase deficiency, 3876 Inhibition of the Mg(II)-ATP-dependent phosphoprotein phosphatase by the regulatory subunit of cAMP-dependent protein kinase, 7565 Glucose transport protein Glucose transport protein is structurally and immunologically related to Glycolate oxidase band 3 and senescent cell antigen, 1731 Structure of glycolate oxidase from spinach, 6855 Glucose uptake Glycolipid Stimulation of glucose uptake by transforming growth factor P: Evidence Repetitive A epitope (type 3 chain A) defined by blood group Al-specific for the requirement of epidermal growth factor-receptor monoclonal antibody TH-1: Chemical basis of qualitative Al and A2 activation, 1346 distinction, 1199 Insulin-stimulated glucose uptake in rat diaphragm during postnatal Fucose-containing glycolipids are stage- and region-specific antigens in development: Lack of correlation with the number of insulin receptors developing embryonic brain of rodents, 3045 and of intracellular glucose transporters, 3621 Repetitive A epitope (type 3 chain A) defined by blood group Al-specific and Glucose utilization monoclonal antibody TH-1: Chemical basis of qualitative Al A2 Prenatal expression of a lethal genetic defect in carbohydrate metabolism distinction (Correction), 3948 in mice, 2101 Glycoipid antigen Differential effects of electrical stimulation of sciatic nerve on metabolic A glycolipid antigen specific to Mycobacterium paratuberculosis: activity in spinal cord and dorsal root ganglion in the rat, 6010 Structure and antigenicity, 3068 a-Glucosidase Glycolipid, sulfated Castanospermine inhibits a-glucosidase activities and alters glycogen Lanunin binds specifically to sulfated glycolipids, 1306 distribution in animals, 93 Glycolipid, surface Glucuronidation Rapid processing of the carboxyl terminus of a trypanosome variant Distribution of UDPglucuronosyltransferase in rat tissue, 2990 surface glycoprotein, 3207 Glued locus Glywolysis Molecular genetics of a transposon-induced dominant mutation in the 3C NMR studies of carbon metabolism in the hyphal fungus Aspergillus Drosophila locus Glued, 1751 nidulans, 14 Inhibition by 2,5-anhydromannitol of glycolysis in isolated rat L-Glutamate hepatocytes and in Ehrlich ascites cells, 78 Primary structure of rat thymus prothymosin a, 343 Stimulation of glycolysis and amino acid uptake in NRK-49F cells by 1H-Observe/13C-decouple spectroscopic measurements of lactate and transforming growth factor and epidermal growth factor, 1350 glutamate in the rat brain in vivo, 1633 Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to with ras or myc oncogenes, 3535 kainate, 1837 Phorbol 12-myristate 13-acetate and insulin increase the concentration of N-Acetylaspartylglutamate: Possible role as the neurotransmitter of the fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo lateral olfactory tract, 3897 fibroblasts, 6440 -Glutamate Methionine-sensitive glycolysis in transformed cells, 6750 )-Fluoromethotrexate: Synthesis and biological activity of a potent Glycoprotein inhibitor of dihydrofolate reductase with greatly diminished ability to From monoclonal antibody to gene for a neuron-specific glycoprotein in form poly--glutamates, 2598 Drosophila, 1855 Glutamnase gene Multiply drug-resistant human KB carcinoma cells have decreased The gene coding for carbamoyl-phosphate synthetase I was formed by amounts of a 75-kDa and a 72-kDa glycoprotein, 2330 fusion of an ancestral glutaminase gene and a synthetase gene, 2244 Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein, 3207 Glutamine synthetase Nucleotide sequence of the G protein gene of human respiratory Expression of ginA in Escherichia coli is regulated at tandem syncytial virus reveals an unusual type of viral membrane protein, 4075 promoters, 1979 A glycoprotein associated with the non-A, non-B hepatitis agent(s): Regulation of expression from the glnA promoter of Bacillus subtilis Isolation and immunoreactivity, 4934 requires the ginA gene product, 3375 Synthesis of analogs of human platelet membrane glycoprotein IIb-Ila Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria complex by chicken peripheral blood thrombocytes, 7319 activate ginA transcription in vitro: Evidence that the ntrA product is a Interaction of purified type IIB von Willebrand factor with the platelet of factor, 7525 membrane glycoprotein lb induces fibrinogen binding to the glycoprotein IIb/Ma complex and initiates aggregation, 7424 Glutaric acidemia Deficiency of electron transfer flavoprotein or electron transfer a2-Glycoprotein flavoprotein:ubiquinone oxidoreductase in glutaric acidemia type II Penodicity of leucine and tandem repetition of a 24-amino acid segment fibroblasts, 4517 in the primary structure of leucine-rich a2-glycoprotein of human serum, 1906 Glutathione Origin and turnover of mitochondrial glutathione, 4668 Glycoproteln D Modification of chromium (VI)-induced DNA damage by glutathione and Human T-lymphocyte response in vitro to synthetic peptides of herpes cytochrome P450 in chicken embryo hepatocytes, 6755 simplex virus glycoprotein D, 3425 8884 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Glycosaminoglycan Granulocyte/macrophage colony-mulatin factor Differences between two fractions of glycosaminoglycans of the corneal Cloning, sequence, and expression of a uman granulocyte/macrophage stroma in their structural relation to collagen, 760 colony-stimulating factor, 6250 Type IX collagen from sternal cartilage of chicken embryo contains covalently bound glycosaminoglycans, 2608 Granulomonocytic stem cell Animal cell mutants defective in glycosaminoglycan biosynthesis, 3197 Generation of functional clonal cell lines from human bone marrow stroma, 3477 Glycosphingolipid Granulosa cell Phylogenetic dichotomy of nerve glycosphingolipids, 6779 Inhibition of gonadotropin-induced granulosa cell differentiation by of 8518 Glycosph ngolipid metabolism activation protein kinase C, Fabry disease: Isolation of a cDNA clone encoding human Gray tremor a-galactosidase A, 7364 Transmissible spongiform encephalopathy in the gray tremor mutant Glycosylation mouse, 253 Influenza viral (A/WSN/33) hemagglutinin is expressed and glycosylated Group action in the yeast Saccharomyces cerevisiae, 2019 Group actions and higher signatures, 1297 Glycyl-L-glutamine GroupzpedMc component Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a Human group-specific component (Gc) is a member of the albumin neurotrophic factor for maintenance of acetylcholinesterase and family, 7994 butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo, 5213 Growth cone Dispersion of growing axons within the optic nerve of the embryonic GM2 gangiosldosls monkey, 3906 Isolation of cDNA clones coding for the , subunit of human Differentiation of neuronal growth cones: Specialization of filopodial tips ,-hexosaminidase, 1184 for adhesive interactions, 8256 Gold Growth factor Immunophotoelectron microscopy: The electron optical analog of Heparin affinity of anionic and cationic capillary endothelial cell growth immunofluorescence microscopy, 109 factors: Analysis of hypothalamus-derived growth factors and Immunophotoelectron microscopy: The electron optical analog of fibroblast growth factors, 805 immunofluorescence microscopy (Correction), 3062 Purification of hemopoietin 1: A multilineage hemopoietic growth factor, 2764 Golgi apparatus A high-efficiency cloning system for single hapten-specific B lymphocytes Transport to cell surface of intestinal sucrase-isomaltase is blocked in the that is suitable for assay of putative growth and differentiation Golgi apparatus in a patient with congenital sucrase-isomaltase factors, 3395 deficiency, 4423 Induction of ornithine decarboxylase activity by insulin and growth Localization of galactosyl- and sialyltransferase by immunofluorescence: factors is mediated by amino acids, 4365 Evidence for different sites, 4736 Induction of ornithine decarboxylase activity by insulin and growth Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at factors is mediated by amino acids (Correction), 8274 the trans pole in polypeptide hormone-secreting cells, 5385 (Glu 62,Ala3o,Tyr8),, serves as high-affinity substrate for tyrosylprotein Growth hormone sulfotransferase: A Golgi enzyme, 6143 Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats, 561 Gonadotropin Inhibition of growth of a prolactin and growth hormone-secreting Expression of biologically active bovine luteinizing hormone in Chinese pituitary tumor in rats by D-tryptophan-6 analog of luteinizing hamster ovary cells, 7280 hormone-releasing hormone, 1252 Biosynthetic 20-kilodalton methionyl-human growth hormone has Gonadotropin-releasmng hormone diabetogenic and insulin-like activities, 4250 Bioeffective monoclonal antibody against the decapeptide Cloning and expression of cDNA for salmon growth hormone in gonadotropin-releasing hormone: Reacting determinant and action on Escherichia coli, 4306 ovulation and estrus suppression, 1228 Growth hormone and insulin-like growth factors I and II produce distinct Characterization of pituitary calcium-activated, phospholipid-dependent alterations in glucose metabolism in 3T3-F442A adipocytes, 8724 protein kinase: Redistribution by gonadotropin-releasing hormone, 8203 Growth hormone gene, human Gonococcus The first intron of the human growth hormone gene contains a binding Antibodies to peptides corresponding to a conserved sequence of site for glucocorticoid receptor, 699 gonococcal pilins block bacterial adhesion, 915 Growth hormone-releasing factor Gorilla Gene encoding human growth hormone-releasing factor precursor: A truncated immunoglobulin E pseudogene is found in gorilla and man Structure, sequence, and chromosomal assignment, 63 but not in chimpanzee, 3712 Levels of human and rat hypothalamic growth hormone-releasing factor as determined by specific radioimmunoassay systems, 2970 gp52 envelope glycoprotein Growth inhibition Characterization of a protein, released by the T47D cell line, inhibition of human immunologically related to the major envelope protein of mouse In vitro screening assay for teratogens using growth mammary tumor virus, 1531 embryonic cells, 5791 Growth Inhibitor gpl40 Type P transforming growth factor/growth inhibitor stimulates entry of gpl40, the C3d receptor of human B lymphocytes, is also the monolayer cultures of AKR-2B cells into S phase after a prolonged Epstein-Barr virus receptor, 1490 prereplicative interval, 4147 gpt gene Growth medium Insertion of the bacterial gpt gene into the germ line of mice by retroviral Maintenance of differentiated rat hepatocytes in primary culture, 3252 infection, 6927 Characterization of cultured rat oligodendrocytes proliferating in a 3509 Gramicidin serum-free, chemically defined medium, Peptide mixture sequencing by tandem Fourier-transform mass Growth rglatIon spectrometry, 6367 Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2, 6932 Granulation tissue Evidence that intracellular magnesium is present in cells at a regulatory Sustained release of epidermal growth factor accelerates wound concentration for 7324 repair, 7340 protein synthesis, GTP a-Granule Phase-change kinetics for a microtubule with two free ends, 431 Platelet-derived collagenase inhibitor: Characterization and subcellular Antibodies specific for amino acid 12 of the ras oncogene product inhibit localization, 2779 GTP binding, 5280 Identification of distinct receptor complexes that account for high- and Granule membrane low-affinity glucagon binding to hepatic plasma membranes, 6835 Selective internalization of granule membrane after secretion in mast cells, 1711 GTP-bhlnlg protein Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils Granulocyte with a GTP-binding protein sensitive to pertussis toxin, 869 Purification and partial amino acid sequence of asialo murine Catalytic unit of adenylate cyclase: Purification and identification by granulocyte-macrophage colony stimulating factor, 292 affinity crosslinking, 3086 Isolation of cDNA for a human granulocyte-macrophage Pertussis toxin inhibits chemotactic peptide-stimulated generation of colony-stimulating factor by functional expression in mammalian inositol phosphates and lysosomal enzyme secretion in human cells, 4360 leukemic (HL-60) cells, 3277 Amino acid sequence of the a subunit of transducin deduced from the Granulocyte functional antigen cDNA sequence, 4311 Selective enhancement of the expression of granulocyte functional GTP-binding membrane protein of Escherichia coli with sequence antigens 1 and 2 on human neutrophils, 2503 homology to initiation factor 2 and elongation factors Tu and G, 7500 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8885

A pertussis toxin-sensitive GTP-binding protein in the human neutrophil Ha-ns protein regulates multiple receptors, calcium mobilization, and lectin-induced Ha-ras proteins exhibit GTPase activity: Point mutations that activate capping, 8643 Ha-ras gene products result in decreased GTPase activity, 376 GTP cap Haar e Monte Carlo study on the GTP cap in a five-start helix model of a The Markoff-Duffin-Schaeffer inequalities abstracted, 955 microtubule, 1131 Theoretical treatment of microtubules disappearing in Haemophilus usfluenm solution, 4127 Processing of donor DNA during Haemophilus influenzae transformation: GTP hydrolysis Analysis using a model plasmid system, 3731 Directed elongation model for microtubule GTP hydrolysis, 3267 A population genetic framework for the study of invasive diseases caused Directed elongation model for microtubule GTP hydrolysis by serotype b strains of Haemophilus influenzae, 5078 (Correction), 7474 Genes from plasmid pKM101 in Haemophilus influenzae: Separation of functions of mucA and mucE, 7753 GTPase Ha-ras proteins exhibit GTPase activity: Point mutations that activate Hafenteng Ha-ras gene products result in decreased GTPase activity, 376 Characterization of a platelet-activating factor receptor antagonist cDNA-derived amino acid sequence of the y subunit of GTPase from isolated from haifenteng (Piperfutokadsura): Specific inhibition of in bovine rod outer segments, 1936 vitro and in vivo platelet-activating factor-induced effects, 672 GTPase of bovine rod outer segments: The amino acid sequence of the a Hair cell subunit as derived from the cDNA sequence, 4316 Perpetual production of hair cells and maturational changes in hair cell Light-activated guanosinetriphosphatase in Musca eye membranes ultrastructure resembles the prolonged depolarizing afterpotential in photoreceptor accompany postembryonic growth in an amphibian cells, 7116 ear, 3911 Halobacteria Guanine n ie binding protein Eubacteria, halobacteria, and the origin of photosynthesis: The Genetic analysis of P-adrenergic receptor internalization and photocytes, 3716 down-regulation, 129 Eubactena, halobacteria, and the origin of photosynthesis: The Antisera against a guanine nucleotide binding protein from retina photocytes (Correction), 7154 cross-react with the 8 subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, N, and Ni, 727 Halobacterinm halobium Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a A neutron diffraction study on the location of the polyene chain of retinal membrane protein in a human.-mouse hybrid cell line, 2637 in bacteriorhodopsin, 3227 Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: Role of G proteins in excitation response Haloperidol coupling, 2708 Neuroleptic drugs attenuate calcium influx and tension development in Antibodies against the carboxyl-terminal 5-kDa peptide of the a subunit rabbit thoracic aorta: Effects of pimozide, penfluridol, chlorpromazine, of transducin crossreact with the 40-kDa but not the 39-kDa guanine and haloperidol, 1237 nucleotide binding protein from brain, 4095 Hamster GTPase of bovine rod outer segments: The amino acid sequence of the a Ontogeny of hamster hemoglobins in yolk-sac erythroid cells in vivo and subunit as derived from the cDNA sequence, 4316 in culture, Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by 2794 Escherichia coli-synthesized Ha-ras encoded p21, 8310 Hamster cell Identification of a single chromosome in the normal human genome Guanine node exchange essential for suppression of hamster cell transformation, 570 Translational control by adenovirus: Lack of virus-associated RNA, during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis, 1959 HaelotypCommon haplotype dependency of high gene expression and high Hb F levels in and Gyglobinsickle cell anemia patients, 2111 Guanosine tetraphosphate P-thalassemia Feedback regulation of rRNA and tRNA synthesis and accumulation of Hapten-gelatin frationation free ribosomes after conditional expression of rRNA genes, 1069 A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation Guilln-Barrd syndrome factors, 3395 Anti-peripheral myelin antibody in patients with demyelinating neuropathy: Quantitative and kinetic determination of serum antibody by complement 1 Electronegativity and hardness as coordinates in structure stability component fixation, 905 diagrams, 264 Gyrase Hardness, softness, and the fukui function in the electronic theory of Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid; metals and catalysis, 6723 The target of the drugs is DNA, 307 Harmonic sequence H-2 antigen Harmonic maps of S2 into a complex Grassmann manifold, 2217 Expression of histocompatibility antigens H-2K, -D, and -L is reduced in Hawaii adenovirus-12-transformed mouse cells and is restored by interferon Ancient origin for Hawaiian Drosophilinae inferred from protein 5,5525 comparisons, 4753 H-2 class I antigen hdv locus Molecular characterization of novel H-2 class I molecules expressed by a Identification of pTiC58 plasmid-encoded proteins for virulence in C3H UV-induced fibrosarcoma, 5485 Agrobacterium tumefaciens, 2669 H-2 region Heart Characterization of a Q subregion gene in the murine major Muscarinic cholinergic receptor in the human heart evidenced under histocompatibility complex, 1503 physiological conditions by positron emission tomography, 584 Multiple duplications of complement C4 gene correlate with Biochemical rationale and myocardial tissue data on the effective therapy H-2-controlled testosterone-independent expression of its sex-limited of cardiomyopathy with coenzyme Qio, 901 isoform, C4-Slp, 1746 Optical measurement of voltage-dependent Ca2+ influx in frog heart, 1864 Expression in L cells of transfected class I genes from the mouse major Preferential orientation of centrioles toward the heart in endothelial cells histocompatibility complex, 5505 of major blood vessels is reestablished after reversal of a Distinct H-2-linked regulation of T-cell responses to the pre-S and S segment, 3272 regions of the same hepatitis B surface antigen polypeptide allows Noninvasive detection and monitoring of regional myocardial ischemia in circumvention of nonresponsiveness to the S region, 8168 situ using depth-resolved 31P NMR spectroscopy, 8747 H-2Db antigen Heart cell Molecular analysis of an EL4 cell line that expresses H-2Db but not Enkephalins have a direct positive inotropic effect on cultured cardiac H-2Kb or P2-microglobulin, 2950 myocytes, 5930 H2-Dd gene Heart disease, viral DNA sequence of the mouse H-2Dd transplantation antigen gene, 1175 Molecular cloning of the genome of a cardiotropic Coxsackie B3 virus: Full-length reverse-transcribed recombinant cDNA generates infectious I.-2kW mutation virus in mammalian cells, 4818 Evidence that polymorphism in the murine major histocompatibility Heat resistance complex may be generated by the assortment of subgene Hear-resistant variants of Chinese hamster fibroblasts altered in sequences, 2890 expression of heat shock protein, 8029 H-2S region Heat shpck gene Liver mRNA probes disclose two cytochrome P450 genes duplicated in Consensus sequence for Escherichia coli heat shock gene tandem with the complement C4 loci of the mouse H-2S region, 4453 promoters, 2679 Ha-ns gene Heat shock protein Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Axonal transport of a heat shock protein in the rabbit visual system, 1281 Escherichia coli-synthesized Ha-ras encoded p21, 8310 Altered gene expression during cold acclimation of spinach, 3673 8886 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

DNA sequence and transcript mapping of a soybean gene encoding a Colony formation by primitive hemopoietic progenitor cells in serum-free small heat shock protein, 3726 medium, 775 Induction of heat shock and stress proteins in promastigotes of three Identification of B cells in multilineage hematopoietic colonies derived Leishmania species, 4414 from cells of patients with lymphocytic lymphoma, 883 Isolation and functional analysis of a human 70,000-dalton heat shock Purification and biochemical characterization of human pluripotent protein gene segment, 4949 hematopoietic colony-stimulating factor, 1526 Self-degradation of heat shock proteins, 4969 Generation of functional clonal cell lines from human bone marrow Transcription of the human hsp7O gene is induced by serum stroma, 3477 stimulation, 6070 Failure to demonstrate pluripotential hemopoietic stem cells in mouse Conserved features of eukaryotic hsp7O genes revealed by comparison brains, 4268 with the nucleotide sequence of human hsp70, 6455 Differentiation of pormal marrow and HL60 cells induced by Heat shock increases the synthesis of the poly(A)-binding protein in antithymocyte globulin, 4823 HeLa cells, 6884 Long terminal repeat sequences impart hematopoietic transformation Heat-resistant variants of Chinese hamster fibroblasts altered in properties to the myeloproliferative sarcoma virus, 5746 expression of heat shock protein, 8029 Developmental regulation of c-myb in normal myeloid progenitor cells, 6937 Heat shock protein gene Cloning of Ly-5 cDNA, 7360 Transcription of Drosophila small hsp-tk hybrid genes is induced by heat Enrichment of hematopoietic precursor cells and cloning of multipotential shock and by ecdysterone in transfected Drosophila cells, 5865 B-lymphocyte precursors, 7414 Hebb synapse Heme Model of cortical organization embodying a basis for a theory of The liver excretes large amounts of heme in bile when heme oxygenase is information processing and memory recall, 2364 inhibited competitively by Sn-protoporphyrin, 8% HeLa cell Molecular dynamics simulation of photodissociation of carbon monoxide Cell-cycle dependence and properties of the HeLa cell DNA polymerase from hemoglobin, 2034 system, 2220 Mechanism of activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid, 3119 Helicase II The 90-kDa component of reticulocyte heme-regulated eIF-2a (initiation Involvement of helicase II (uvrD gene product) and DNA polymerase I in factor 2 a-subunit) kinase is derived from the , subunit of excision mediated by the uvrABC protein complex, 4925 spectrin, 5332 Heliobacterium chlorum Heme biosynthesis Excited states and primary photochemical reactions in the photosynthetic Isolation of recombinant cDNAs encoding chicken erythroid bacterium Heliobacterium chlorum, 6865 8-aminolevulinate synthase, 3702 Helisoma tnvolvis Heme oxygenase Peptidergic modulation of patterned motor activity in identified neurons The liver excretes large amounts of heme in bile when heme oxygenase is of Helisoma, 7140 inhibited competitively by Sn-protoporphyrin, 8% Cloning and expression of cDNA for rat heme oxygenase, 7865 a-Helix Effect of side chain-backbone electrostatic interactions on the stability of Heme transport a-helices, 5585 Complete amino acid sequence of human hemopexin, the heme-binding protein of serum, 73 Helix-destabilizing protein Identification of a nucleic acid helix-destabilizing protein from rat liver as Hemerythrin lactate dehydrogenase-5, 5260 Active site structures of deoxyhemerythrin and oxyhemerythrin, 713 Influence of solvent accessibility and intermolecular contacts on atomic Helix pomatia mobilities in Biochemical and immunological evidence for a cardiodilatin-like hemerythrins, 1104 substance in the snail neurocardiac axis, 7762 Hemin Helix stability Heemin inhibits internalization of transferrin by reticulocytes and Nature of the charged-group effect on the stability of the C-peptide promotes phosphorylation of the membrane transferrin receptor, 5170 helix, 2349 Hemocyanin Helix-turn-helix Centipedal hemocyanin: Its structure and its implications for arthropod Mutational studies with the trp repressor of Escherichia coli support the phylogeny, 3721 helix-turn-helix model of repressor recognition of operator DNA, 483 Hemoglobin Dominant negative mutations in the TnlO tet repressor: Evidence for the Reexamination of the evidence for paramagnetism in oxy- and use of the conserved helix-turn-helix motif in DNA binding, 6226 carbonmonoxyhemoglobins, 102 Molecular dynamics simulation of photodissociation of carbon monoxide Helinth infection from hemoglobin, 2034 Depletion of mucosal mast cell protease by corticosteroids: Effect on Carbonic anhydrase is aberrantly and constitutively expressed in both intestinal anaphylaxis in the rat, 1214 human and murine erythroleukemia cells, 5175 Helper factor Experimental resolution of cooperative free energies for the ten ligation Xenogeneic antiserum to soluble products from activated lymphoid cells states of human hemoglobin, 5347 inhibits interleukin 1-mediated functions in the helper pathway of A mutation in the P-globin gene detected in the progeny of a female cytolytic-effector-cell differentiation, 1513 mouse treated with ethylnitrosourea, 5829 Immunological detection of hemoglobin in bones of ancient Roman times Helper T lymphocyte and of Iron and Eneolithic Ages, 7170 Use of a cDNA expression vector for isolation of mouse interleukin 2 Oxygen binding properties of human mutant hemoglobins synthesized in cDNA clones: Expression of T-cell growth-factor activity after Escherichia coli, 7252 transfection of monkey cells, 68 Two separate functions of class II (Ia) molecules: T-cell stimulation and Hemoglobin F B-cell excitation, 516 Common haplotype dependency of high Gyglobin gene expression and Rearrangement and transcription of a T-cell receptor A-chain gene in high Hb F levels in P-thalassemia and sickle cell anemia patients, 2111 different T-cell 531 subsets, Hemoglobin Long Island The 1 domain of the mouse Ep chain is important for restricted antigen presentation to helper T-cell hybridomas, 1678 Hb Long Island: A hemoglobin variant with a methionyl extension at the NH2 terminus and a prolyl substitution for the normal histidyl residue Hemagglutinin 2 of the , chain, 4602 Reovirus hemagglutinin mRNA codes for two polypeptides in overlapping reading frames, 48 Hemoglobin ontogeny Isolation and biochemical characterization of the mammalian reovirus Ontogeny of hamster hemoglobins in yolk-sac erythroid cells in vivo and type 3 cell-surface receptor, 1494 in culture, 2794 Structure of proteins with single-site mutations: A minimum perturbation approach, 1697 Hemoglobin S Influenza viral (A/WSN/33) hemagglutinin is expressed and glycosylated Visualization of oriented hemoglobin S in individual erythrocytes by in the yeast Saccharomyces cerevisiae, 2019 differential extinction of polarized light, 6527 General method for the rapid solid-phase synthesis of large numbers of Hemoglobin South filorida peptides: Specificity of antigen-antibody interaction at the level of Amino-terminal processing of proteins: Hemoglobin South Florida, a individual amino acids, 5131 variant with retention of initiator methionine and Na-acetylation, 8448 Hemagglutinin/neuraminl se protein Hemoglobin variant Expression at the cell surface of biologically active fusion and Detection of neutral amino acid substitutions in proteins, 7646 hemagglutinin/neuraminidase proteins of the paramyxovirus simian virus 5 from cloned cDNA, 7520 Hemoglobinuria, paroxysmal nocturnal Amelioration of lytic abnormalities of paroxysmal nocturnal Hematopolesis hemoglobinuria with decay-accelerating factor, 2980 Transfer of genes into hematopoietic cells using recombinant DNA viruses, 158 Hemolymph binding protein Interferon is a mediator of hematopoietic suppression in aplastic anemia High specific activity enantiomerically enriched juvenile hormones: in vitro and possibly in vivo, 188 Synthesis and binding assay, 5290 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8887

Hemolysis Hepatocellular carcinoma Proteolytic modification of human complement protein C9: Loss of Inversely repeating integrated hepatitis B virus DNA and cellular flanking poly(C9) and circular lesion formation without impairment of sequences in the human hepatoma-derived cell line huSP, 208 function, 2128 Duck hepatitis B virus DNA in liver and serum of Chinese ducks: 6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme Integration of viral DNA in a hepatocellular carcinoma, 5180 deficiency: Possible interaction with glucose-6phosphate dehydrogenase deficiency, 3876 Hepatocyte Enhanced complement-mediated lysis of type m paroxysmal nocturnal Isolation and partial characterization of a fatty acid binding protein in rat hemoglobinuria erythrocytes involves increased C9 binding and liver plasma membranes, 4 polymerization, 5520 Direct cross-linking of U¶I-labeled glucagon to its membrane receptor by UV irradiation, 325 Hemolytic anemia Reduction of gap junctional conductance by microinjection of antibodies Characterization of the enzymatic lesion in inherited phosphofructokinase against the 27-kDa liver gap junction polypeptide, 2412 deficiency in the dog: An animal analogue of human glycogen storage Maintenance of differentiated rat hepatocytes in primary culture, 3252 disease type VII, 8109 Hepatocyte-stimulating factor Hemopexin Identification and partial characterization of hepatocyte-stimulating factor Complete amino acid sequence of human hemopexin, the heme-binding from leukemia cell lines: Comparison with interleukin 1, 1443 protein of serum, 73 Hepatoma Hemophilia Hepatitis B virus integration in hepatocellular carcinoma DNA: Polymorphism of normal factor IX detected by mouse monoclonal Duplication of cellular flanking sequences at the integration site, 4458 antibodies, 3839 Localization of human factor FVIII inhibitor epitopes to two polypeptide Hepatoma cell fragments, 7728 Expression of the mouse serum albumin gene introduced into Purified human factor VIII procoagulant protein: Comparative hemostatic differentiated and dedifferentiated rat hepatoma cells, 765 response after infusions into hemophilic and von Willebrand disease dogs, 8752 Herb, Chinese Characterization of a platelet-activating factor receptor antagonist Hemopoletin 1 isolated from haifenteng (Piperfutokadsura): Specific inhibition of in Purification of hemopoietin 1: A multilineage hemopoietic growth vitro and in vivo platelet-activating factor-induced effects, 672 factor, 2764 Herpes simplex virus Henderson Iland The herpes simplex virus amplicon: Analyses of cis-acting replication Bird remains from an archaeological site on Henderson Island, South functions, 694 Pacific: Man-caused extinctions on an "uninhabited" island, 6191 Human T-lymphocyte response in vitro to synthetic peptides of herpes simplex virus glycoprotein D, 3425 Henny feathering trait Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase 5-Azacytidine and sodium butyrate induce expression of aromatase in involves improved nucleotide selection, 3889 fibroblasts from chickens carrying the henny feathering trait but not Potentiation of antiherpetic activity of acyclovir by ribonucleotide from wild-type chickens, 3005 reductase inhibition, 4254 Heparan sulfate Application of the mini-Mu-phage for target-sequence-specific insertional Animal cell mutants defective in glycosaminoglycan biosynthesis, 3197 mutagenesis of the herpes simplex virus genome, 4773 Basement membrane heparan sulfate proteoglycans are concentrated in Identification of immediate early genes from herpes simplex virus that the laminae rarae and in of the rat renal 32% transactivate the virus thymidine kinase gene, 5265 podocytes glomerulus, Nucleotide sequence and predicted amino acid sequence of a protein Heparin encoded in a small herpes simplex virus DNA fragment capable of Heparin affinity of anionic and cationic capillary endothelial cell growth trans-inducing a genes, 5870 factors: Analysis of hypothalamus-derived growth factors and Sequence and mapping analyses of the herpes simplex virus DNA fibroblast growth factors, 805 polymerase gene predict a C-terminal substrate binding domain, 7969 Interaction of endothelial cell growth factor with heparin: Multistep transformation by defined fragments of herpes simplex virus Characterization by receptor and antibody recognition, 6138 type 2 DNA: Oncogenic region and its gene product, 8493 Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography, 8044 Heterodontu francisci Immunoglobulin VH gene structure and diversity in Heterodontus, a Heparin cofactor II phylogenetically primitive shark, 2082 Inhibition of chymotrypsin by heparin cofactor II, 6431 Heterogeneous nuclear RNA-protein complex Hepatitis A virus Specific regions of the intervening sequences of P-globin RNA are Sequence analysis of hepatitis A virus cDNA coding for capsid proteins resistant to nuclease in 50S heterogeneous nuclear RNA-protein and RNA polymerase, 2143 complexes, 8414 Primary structure and gene organization of human hepatitis A virus, 2627 2,5-Hexanedione Hepatitis B surface antigen Giant axonal neuropathy: Acceleration of neurofilament transport in optic A frameshift mutation of the pre-S region of the human hepatitis B virus axons, 920 genome allows production of surface antigen particles but eliminates binding to polymerized albumin, 3440 Hexokinase Multiple chemical forms of hepatitis B surface antigen produced in High glucose concentrations partially release hexokinase from inhibition yeast, 6830 by glucose 6-phosphate, 1552 Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows 3-Hexosamlnidase circumvention of nonresponsiveness to the S region, 8168 Isolation of cDNA clones coding for the .8 subunit of human P-hexosaminidase, 1184 Heanstits B virus Human 3-hexosaminidase a chain: Coding sequence and homology with Hybrid hepatitis B virus-host transcripts in a human hepatoma cell, 83 the 8 chain, 7830 Infectious hepatis B virus from cloned DNA of known nucleotide sequence, 891 High density lipoprotein A frameshift mutation of the pre-S region of the human hepatitis B virus Proapolipoprotein A-I conversion kinetics in vivo in human and in genome allows production of surface antigen particles but eliminates rat, 874 binding to polymerized albumin, 3440 Comparative analysis of repeated sequences in rat apolipoproteins A-I, Hepatitis B virus integration in hepatocellular carcinoma DNA: A-IV and E, 992 Duplication of cellular flanking sequences at the integration site, 4458 Expression in Escherichia coli of a cloned DNA sequence encoding the High density lipoprotein receptor pre-S2 region of hepatitis B virus, 7540 Tangier disease: A disorder of intracellular membrane traffic, 6305 Hepatitis B virus DNA Hinge-bending mode inversely repeating integrated hepatitis B virus DNA and cellular flanking Normal modes for specific motions of macromolecules: Application to sequences in the human hepatoma-derived cell line huSP, 208 the hinge-bending mode of lysozyme, 4995 Duck hepatitis B virus DNA in liver and serum of Chinese ducks: Integration of viral DNA in a hepatocellular carcinoma, 5180 Hinge region Deletions within a hinge region of a specific DNA-binding protein, 2301 Hepatitis B virus surface antigen Expression in Escherichia coli of a cloned DNA sequence encoding the Hippocampus pre-S2 region of hepatitis B virus, 7540 GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal Expression of hepatitis B surface antigen with a recombinant cells in hippocampal cultures, 1558 adenovirus, 7560 Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: Electrophysiological effects of phorbol esters, 2538 Hepatitis, non-A, non-B Production of antibody associated with non-A, non-B hepatitis in a HIS4 gene chimpanzee lymphoblastoid cell line established by in vitro A synthetic HIS4 regulatory element confers general amino acid control transformation with Epstein-Barr virus, 2138 on the cytochrome c gene (CYCI) of yeast, 498 A glycoprotein associated with the non-A, non-B hepatitis agent(s): The relationship between the "TATA" sequence and transcription Isolation and immunoreactivity, 4934 initiation sites at the HIS4 gene of Saccharomyces cerevisiae, 8557 8888 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) hisA gene HLA-DQ subregion Structure and sequence divergence of two archaebacterial genes, 4207 Allelic polymorphism and transassociation of molecules encoded by the HLA-DQ subregion, 1776 Hlistidine Site-specific mutagenesis of histidine residues in the lac permease of HLA-DR antigen Escherichia coli, 6765 Structural organization of the DR subregion of the human major Histocompatibility antigen histocompatibility complex, 5165 A systematic study of HLA class II-P DNA restriction fragments in HLA-DR A-chain ene insulin-dependent diabetes mellitus, 3335 Linkage map of three HLA-DR P-chain genes: Evidence for a recent Three-dimensional structure of P2-microglobulin, 4225 duplication event, 7197 Recognition of interspecies hybrid class I histocompatibility antigens by antigen-specific cytolytic T lymphocytes, 6276 HLA-DRa gene Alloreactive cytolytic T-cell clones preferentially recognize Polymorphic restriction endonuclease sites linked to the HLA-DRa gene: conformational determinants on histocompatibility antigens: Analysis Localization and use as genetic markers of insulin-dependent with genetically engineered hybrid antigens, 7030 diabetes, 8100 Histone HLA region Deposition-related histone acetylation in micronucleus of conjugating Mapping of steroid 21-hydroxylase genes adjacent to complement Tetrahymena, 8048 component C4 genes in HLA, the major histocompatibility complex in man, 521 Histone 2A Two genes encoding steroid 21-hydroxylase are located near the genes Preparations of homeostatic thymus hormone consist predominantly of encoding the fourth component of complement in man, 1089 histones 2A and 2B and suggest additional histone functions, 4871 Deletion mapping of HLA and chromosome 6p genes, 3741 Histone gene Holliday junction Structure of a human histone cDNA: Evidence that basally expressed Cleavage of cruciform DNA structures by an activity from histone genes have intervening sequences and encode polyadenylylated Saccharomyces cerevisiae, 6445 mRNAs, 2834 Partial Biphasic pattern of histone gene expression during Drosophila purification of an enzyme from Saccharomyces cerevisiae that oogenesis, 3316 cleaves Holliday junctions, 7247 Histone H4 Homeostatic thymus hormone A unique subspecies of histone H4 mRNA from rat myoblasts contains Preparations of homeostatic thymus hormone consist predominantly of poly(A), 6760 histones 2A and 2B and suggest additional histone functions, 4871 Histone H4 gene Homogeneously staining region Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is N-myc amplification in multiple homogeneously staining regions in two controlled by sequences in the 3'-terminal part of the gene, 4389 human neuroblastomas, 3736 Regulated expression of mammalian histone H4 genes in vivo requires a Homology trans-acting transcription factor, 5622 Prediction of homology and divergence in the secondary structure of Replication timing of the H4 histone genes in Physarum polypeptides, 366 polycephalum, 6475 Presence of two distinct regions in the coiled-coil structure of the A human histone H4 gene exhibits cell cycle-dependent changes in streptococcal Pep MS protein: Relationship to mammalian coiled-coil chromatin structure that correlate with its expression, 7535 proteins and implications to its biological properties, 1064 Histone mRNA Mouse-Torpedo hybrid acetylcholine receptors: Functional homology Synthesis of sperm and late histone cDNAs of the sea urchin with a does not equal sequence homology, 4852 primer complementary to the conserved 3' terminal palindrome: Evidence for tissue-specific and more general histone gene Homozygosity variants, 5676 Homozygosity, effective number of alleles, and interdeme differentiation Quantitative and qualitative changes in histone gene expression during in subdivided populations, 8611 early mouse embryo development, 5685 Horizontal cell Histone RNA Dopamine decreases conductance of the electrical junctions between Polyadenylylation of sea urchin histone RNA sequences in transfected cultured retinal horizontal cells, 3025 COS cells, 1094 Hormone, controlled release "Hit-and-run", tumorienesis Radioimmunoassay for 6-D-tryptophan analog of luteinizing Plasmid-induced "hit-and-run" tumorgenesis in Chinese hamster embryo hormone-releasing hormone: Measurement of serum levels after fibroblast (CHEF) cells, 2839 administration of long-acting microcapsule formulations, 1547 HLA antigen Hormone receptor See also Class I antigen and Class II antigen Interleukin 2 regulates its own receptors, 864 Human major histocompatibility complex class I antigens: Residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site, 539 Hormone-secreting cell Characterization of an HLA DRB pseudogene, 1475 Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at Nucleotide sequence of an HLA-DQ a chain derived from a DRw9 cell the trans pole in polypeptide hormone-secreting cells, 5385 line: Genetic and evolutionary implications, 3420 Human cytotoxic T-lymphocyte recognition of an HLA-A3 gene product hsp7O gene expressed on murine L cells: The only human gene product required Isolation and functional analysis of a human 70,000-dalton heat shock on the target cells for lysis is the class I heavy chain, 4490 protein gene segment, 4949 Structural analysis of an HLA-B27 functional variant: Identification of Transcription of the human hsp7O gene is induced by serum residues that contribute to the specificity of recognition by cytolytic T stimulation, 6070 lymphocytes, 7394 Conserved features of eukaryotic hsp7O genes revealed by comparison Mutations that impair a posttranscriptional step in expression of HLA-A with the nucleotide sequence of human hsp7o, 6455 and -B antigens, 8183 Human T-cell leukemia virus HLA antigen, cla II Identification of new gene products coded from X regions of human A systematic study of HLA class II-, DNA restriction fragments in T-cell leukemia viruses, 302 insulin-dependent diabetes mellitus, 3335 Complete nucleotide sequence of the genome of bovine leukemia virus: DNA sequence and characterization of human class II major Its evolutionary relationship to other retroviruses, 677 histocompatibility complex n chains from the DR] haplotype, 3405 Influence of the human T-lymphotropic virus/lymphadenopathy- Gene organization of DC and DX subregions of the human major associated virus on functions of human lymphocytes: Evidence for histocompatibility complex, 3410 immunosuppressive effects and polyclonal B-cell activation by banded Intracellular class II HLA antigens are accessible to transferrin- viral preparations, 8198 neuraminidase conjugates internalized by receptor-mediated Human T-cell growth factor (interleukin 2) and v-interferon genes: endocytosis, 8188 Expression in human T-lymphotropic virus type III- and type I-infected cells, 8691 HLA-B locus HLA-B locus polymorphism: Studies with a specific hybridization Human T-cell leukemia virus type I probe, 8614 Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor, 2277 HLA clasm locus Location of cis-acting regulatory sequences in the human T-cell leukemia Use of pooled DNA samples to detect linkage disequilibrium of virus type I long terminal repeat, 6502 polymorphic restriction fragments and human disease: Studies of the p27x-m and p21-x, proteins encoded by the pX sequence of human HLA class II loci, 6970 T-cell leukemia virus type I, 8359 HLA-DQ andt Human T-cel ukemia *rus type H Identification of a polymorphic variant associated with HLA-DQw3 and Complete nucleotide sequence of an infectious clone of human T-cell characterized by specific restriction sites within the DQ a9-chain luekemia virus type II: An open reading frame for the proteasn gene, 8139 gene, 3101 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8889

Human T-cell leukemia virus type M 9-{[2-Hydrozy-1-(hydroxymethyIlethoxv1methylJguanlne Immunological properties of the Gag protein p24 of the acquired Metabolic activation of the nucleoside analog 9-{[2-hydroxy-1- immunodeficiency syndrome retrovirus (human T-cell leukemia virus (hydroxymethyl)ethoxy]methyl}guanine in human diploid fibroblasts type III), 3481 infected with human cytomegalovirus, 2473 Genomic diversity of the acquired immune deficiency syndrome virus HTLV-llI: Different viruses exhibit greatest divergence in their 4-Hydroxy-3-methoxyphenyl glycol envelope genes, 4813 Human class I alcohol dehydrogenases catalyze the oxidation of glycols A glycoprotein associated with the non-A, non-B hepatitis agent(s): in the metabolism of norepinephrine, 4979 Isolation and immunoreactivity, 4934 3-Hydroxy-2-methyl-3-phytyl-2,3-dhydronaphthoquInone Monoclonal antibodies specific or p24, the major core protein of human Purification of a vitamin K epoxide reductase that catalyzes conversion T-cell leukemia virus type III, 5199 of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3- Isolation of infectious human T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome dihydronaphthoquinone, 2713 (AIDS) or AIDS-related complex (ARC) and from healthy carriers: A 3-Hydroxy-3-methylglutaryl-oeenzyme A reductase study of risk groups and tissue sources, 5530 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in 3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits peroxisomes in normal rat liver cells, 770 the infectivity and cytopathic effect of human T-lymphotropic virus Characterization and sequence of the promoter region of the human type IHl/lymphadenopathy-associated virus in vitro, 7096 epidermal growth factor receptor gene, 4920 Human genes involved in cholesterol metabolism: Chromosomal mapping Human T-lymphotropic virus of the loci for the low density lipoprotein receptor and See Human T-cell leukemia virus 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA hup gene probes, 8567 Intra- and interspecies transfer and expression of Rhizobium japonicum 3-Hydroxy-3-methy4gutaryl-coenzyme A synthase hydrogen uptake genes and autotrophic growth capability, 3232 Defective macromolecule biosynthesis and cell-cycle progression in a Hyaloh cecropia mammalian cell starved for mevalonate, 3257 Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin 12-Hydroxyicosatetraenoic acid B from Hyalophora cecropia, 2240 Glucose increases the synthesis of lipoxygenase-mediated metabolites of Hybrid dysgenesis arachidonic acid in intact rat islets, 198 P-element distribution in Eurasian populations of Drosophila Circulating hydroxy fatty acids in familial Mediterranean fever, 1232 melanogaster: A genetic and molecular analysis, 5418 21-Hydroxylase P-element distribution in Eurasian populations of Drosophila Expression of murine 21-hydroxylase in mouse adrenal glands and in melanogaster: A genetic and molecular analysis (Correction), 7802 Y1 adrenocortical tumor cells, 7860 Transposase titration in Drosophila melanogaster: A model of cytotype transfected in the P-M system of hybrid dysgenesis, 8119 19-Hydroxylation Hybridization in situ 19-Hydroxylation of androgens in the rat brain, 2728 Identification of individual interferon-producing cells by in situ Hydroxylation, aromatic hybridization, 1136 Catabolism of premercapturic acid pathway metabolites of naphthalene to 668 Hybridization tomography naphthols and methylthio-containing metabolites in rats, Natural history of restricted synthesis and expression of measles virus Hydroxylysine genes in subacute sclerosing panencephalitis, 3020 Processing of an anglerfish somatostatin precursor to a hydroxylysine-containing somatostatin 28, 277 Hybridoma Phosphorylation of hydroxylysine residues in collagen synthesized by Monoclonal human thyroid cell line GEJ expressing human thyrotropin cultured aortic muscle cells, 3091 receptors, 2120 smooth Isolation of cDNA clones encoding a T-cell receptor a-chain from a beef (1)-lla-Hydroxyprogste insulin-specific hybridoma, 8163 Total synthesis of (±)lla-hydroxyprogesterone by cyclization of a epoxide, 1879 Hydration polyunsaturated Protonic conductivity of hydrated lysozyme powders at megahertz Hydroxyproline-rich glycoprotein frequencies, 5342 Accumulation of hydroxyproline-rich glycoprotein mRNAs in response to elicitor and infection, 6551 Hydrocarbon, polycyclic aromatic fungal Oxidant-dependent metabolic activation of polycyclic aromatic Hypercholesterolemia, heterozygous familial hydrocarbons by phorbol ester-stimulated human polymorphonuclear The influence of mevinolin on the adrenal cortical response to leukocytes: Possible link between inflammation and cancer, 5194 corticotropin in heterozygous familial hypercholesterolemia, 6291 Hydrogen bond Hyperglycemia Modification of pK values caused by change in H-bond geometry, 2741 Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: Implications for human Hydrogen ion diabetes, 1544 See Proton Hyperglycemia-induced teratogenesis is mediated by a functional Hydrogen ion concentration deficiency of arachidonic acid, 8227 See pH Hypermutation Hydrogen ion gradient Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell Active auxin uptake by zucchini membrane vesicles: Quantitation using line, 479 ESR volume and ApH determinations, 6541 Hyperplastic nodule Electron transfer-driven ATP synthesis in Methanococcus voltae is not Purification, induction, and distribution of placental glutathione dependent on a proton electrochemical gradient, 6793 transferase: A new marker enzyme for preneoplastic cells in the rat Hydrogen peroxide chemical hepatocarcinogenesis, 3964 The production of DNA strand breaks in human leukocytes by Hypertension superoxide anion may involve a metabolic process, 6820 Inhibition of thromboxane synthesis ameliorates the progressive kidney Administration of recombinant interferon to cancer patients enhances disease of rats with subtotal renal ablation, 193 monocyte secretion of hydrogen peroxide, 8686 Increased angiotensin II binding affinity in the nucleus tractus solitarius Hydrogen uptake gene of spontaneously hypertensive rats, 7721 Intra- and interspecies transfer and expression of Rhizobium japonicum Hyprtrophy, renal hydrogen uptake genes and autotrophic growth capability, 3232 BSC-1 growth inhibitor transforms a mitogenic stimulus into a hypertrophic stimulus for renal proximal tubular cells: Relation to Hydrogenase 6163 Stereochemical studies of a selenium-containing hydrogenase from Na+/H+ antiport activity, Methanococcus vannielii: Determination of the absolute configuration Hypothalamus of C-5 chirally labeled dihydro-8-hydroxy-5-deazaflavin cofactor, 1364 Gene encoding human growth hormone-releasing factor precursor: Intra- and interspecies transfer and expression of Rhizobium japonicum Structure, sequence, and chromosomal assignment, 63 hydrogen uptake genes and autotrophic growth capability, 3232 Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats, 561 5-Hydroperoxylcosatetraenolc add Electroconvulsive shock increases preproenkephalin messenger RNA On the nature of the 5-lipoxygenase reaction in human leukocytes: abundance in rat hypothalamus, 589 Enzyme purification and requirement for multiple stimulatory Levels of human and rat hypothalamic growth hormone-releasing factor factors, 6040 as determined by specific radioimmunoassay systems, 2970 Hydrophobicity Neuropeptide Y injected in the paraventricular hypothalamus: A Nasal absorption of insulin: Enhancement by hydrophobic bile salts, 7419 powerful stimulant of feeding behavior, 3940 Vasopressin mRNA in situ hybridization: Localization and regulation Hydroxide studied with oligonucleotide cDNA probes in normal and Brattleboro Stabilization of higher-valent states of iron porphyrin by hydroxide and rat hypothalamus, 5555 methoxide ligands: Electrochemical generation of iron(IV)-oxo Isolation and amino acid sequence of corticotropin-releasing factor from porphyrins, 4301 pig hypothalami, 8762 8890 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Hypothalamus-derived growth factor Insertion of long interspersed repeated elements at the Igh Heparin affinity of anionic and cationic capillary endothelial cell growth (immunogiobulin heavy chain) and Mlvi-2 (Moloney leukemia virus factors: Analysis of hypothalamus-derived growth factors and integration 2) loci of rats, 2857 fibroblast growth factors, 805 Imidazole ring Hypoxanthine In situ enzymatic reclosure of opened imidazole rings of purines in DNA Hypoxanthine is the principal inhibitor of murine oocyte maturation in a damaged by y-irradiation, 633 low molecular weight fraction of porcine follicular fluid, 454 Immob~ilization Hypoxanthine phosphorlbosyltansferae Evidence for a role of endogenous corticotropin-releasing factor in cold, Ghal cells metabolically cooperate: A potential requirement for gene ether, immobilization, and traumatic stress, 1247 replacement therapy, 6662 Immortalization Hypoxia Avian myelocytomatosis virus immortalizes differentiated quail Oxygen chemoreception by carotid body cells in culture, 1448 chondrocytes, 2756 Friend murine leukemia virus-immortalized myeloid cells are converted I-A polypeptide into tumorigenic cell lines by Abelson leukemia virus, 3306 'Ixon-shuffling" maps control of antibody- and T-cell-recognition sites to Identification and expression of a nuclear antigen from the genomic the NH2-terminal domain of the class II major histocompatibility region of the Jijoye strain of Epstein-Barr virus that is missing in its polypeptide Aft 2940 deletion mutant, 7429 "Exon-shuffling' maps control of antibody- and T-cell-recognition sites to nonimmortalizing P3HR-1, the NH2-terminal domain of the class II major histocompatibility Immune complex polypeptide An (Correction), 5236 The Clq subunit of the first component of complement binds to laminin: A mechanism for the deposition and retention of immune complexes in basement redicted protein sequence of the murine I-Ep' polypeptide chain from membrane, 3824 cDNA and genomic clones, 2910 Immune recognition Identical short peptide sequences in unrelated proteins can have different I-J determinant conformations: A testing ground for theories of immune Use of anti-idiotypic antibodies to identify a receptor for the T-cell I-J recognition, 5255 determinant, 7399 Immune response I-J epitope Predicted protein sequence of the murine polypeptide chain from Involvement of I-J epitopes in the self- and allo-recognition sites of T cDNA and genomic clones, 2910 I-Ep' cells: Blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti-I-J antibodies, 2905 Immune response gene The murine bml2 gene conversion provides evidence that T cells reglon recognize predominantly Ia conformation, 7058 The I region of the C57BL/10 mouse: Characterization and physical linkage to H-2K of an SBP-like class II pseudogene, i*Af3, 5500 Immune system, normal Natural effector T in normal 7691 I region restriction lymphocytes mice, Bone marrow-derived thymic antigen-presenting cells determine Immunocytochemistry self-recognition of Ia-restricted T lymphocytes, 5900 Microtubule distribution in cultured cells and intact tissues: Improved immunolabeling resolution through the use of reversible embedment la antigen 6889 A molecular basis for the Ia.2 and Ia.19 antigenic determinants, 2930 cytochemistry, DNA sequence and characterization of human class II major Immunodefilency histocompatibility complex P chains from the DRi haplotype, 3405 Expression of human adenosine deaminase using a transmissable murine Nucleotide sequence of an HLA-DQ a chain derived from a DRw9 cell retrovirus vector system, 703 line: Genetic and evolutionary implications, 3420 Cells from an immunodeficient patient (46BR) with a defect in DNA Reactivation by a trans-acting factor of human major histocompatibility ligation are hypomutable but hypersensitive to the induction of sister complex Ia gene expression in interspecies hybrids between an chromatid exchanges, 2044 Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma, 5145 Immunofluorescence T-cell activation by peptide antigen: Effect of peptide sequence and Expression of a second Epstein-Barr virus-determined nuclear antigen in method of antigen presentation, 5480 mouse cells after gene transfer with a cloned fragment of the viral la-transfected L-cell fibroblasts present a lysozyme peptide but not a genome, 3435 native protein to lysozyme-specific T cells, 5885 Monoclonal antibodies against human Ia antigens stimulate monocytes to Immunofluorescence assay secrete interleukin 1, 6652 High prevalence of antibodies to acquired immune deficiency syndrome The murine bml2 gene conversion provides evidence that T cells (AIDS)-associated retrovirus (ARV) in AIDS and related conditions but recognize predominantly Ia conformation, 7058 not in other disease states, 5535 Immunofiorescence micrscopy Icosanoid Immunophotoelectron microscopy: The electron optical analog of Circulating hydroxy fatty acids in familial Mediterranean fever, 1232 immunofluorescence microscopy, 109 Femtomole analysis of prostaglandin pharmaceuticals, 8315 Immunophotoelectron microscopy: The electron optical analog of Icosapentaenoic acid immunofluorescence microscopy (Correction), 3062 Leukotriene B5 is formed in human neutrophils after dietary Imuogenl supplementation with icosapentaenoic acid, 1540 Interspersed blocks of repetitive and charged amino acids in a dominant Identity coefficient immunogen of Plasmodiumfalciparum, 543 Variances and covariances of identity coefficients of a multigene Analysis of an evolutionarily conserved antigenic site on mammalian family, 829 cytochrome c using synthetic peptides, 1508 Idiotope Immunogenicity Gene repertoire of the anti-poly(Glu60Ala-0Tyr10) (GAT) immune Carboxyl-terminal domain of the Epstein-Barr virus nuclear antigen is response: Comparison of VH, V,,, and D regions used by anti-GAT highly immunogenic in man, 6300 antibodies and monoclonal antibodies produced after anti-idiotypic Immungobun immunization, 4788 Analysis of cDNA clones specific for human T cells and the a and - a T-cell Idiotype chains of the T-cell receptor heterodimer from human Cross-reactive idiotypes and common antigen binding specificities line, 3430 expressed by a senes of murine B-cell lymphomas: Etiological Preferential rearrangement of the immunoglobulin K chain joining region implications, 3799 Jhi and JK2 segments in mouse spleen DNA, 6399 Shared idiotopes among antibodies encoded by heavy-chain variable Immumoglobula A region (VH) gene members of the J558 VH family as basis for Immunoglobulin gene rearrangements and deletions in human cross-reactive regulation of clones with different antigen Epstein-Ban virus-transformed cell lines producing different IgG and specificity, 7696 IgA subclasses, 5495 Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised Immunogiobu dassswitchi_ g against a private rabbit idiotype, 8149 Immunoglobulin JH, C, and Cy gene rearrangements in human B lymphocytes clonally transformed by Epstein-Barr virus, 556 Idiotype suppression Antigen induces chronic idiotype suppression, 4217 Immunoglobulln diversity region Gene repertoire of the anti-poly(Glu6sAla0Tyrl) (GAT) immune IgG Fc receptor response: Comparison of VH, VK, and D regions used by anti-GAT Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG antibodies and monoclonal antibodies produced after anti-idiotypic Fc receptor, 7706 immunization, 4788 Igh gene Immunoglobuln E Suppressor T-cell factor(s) display an altered pattern of Igh B cells that simultaneously express surface IgM and IgE in (immunoglobulin heavy chain locus) genetic restriction when developed Nippostrongylus brasiliensis-infected SJA/9 mice do not provide in an Igh-congeneic host, 2133 evidence for isotype switching without gene deletion, 511 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8891

cDNA clones encoding IgE-binding factors from a rat-mouse T-cell Immunoglobuhin light chain hybridoma, 2460 cDNA of the imiunoglobulin K chain of an Epstein-Barr Suppression of IgE secretion from hybridoma cells in allotype cogenic virus-transformed human lymphoid cell line: Partial sequence mice: Suppression of allotype 7a by T cells in allotype b mice, 8134 determination and bacterial expression, 7025 Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells, 8193 mmunoglobulin light chain gene Alternative splicing patterns in an aberrantly rearranged immunoglobulin Immunoglobulin E binding protebp K-light-chain gene, 4045 cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma, 2460 Immunoglobulin M Identification of an IgE-binding protein by molecular cloning, 4100 B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA/9 mice do not provide lImmunoglobulin E receptor evidence for isotype switching without gene deletion, 511 The receptor for immunoglobulin E on rat basophilic leukemia cells: Protection against Gram-negative bacteremia and endotoxemia with Effect of ligand binding on receptor expression, 1522 human monoclonal IgM antibodies, 1790 Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently Immunoglobulin E antigens for IgM paraproteins, 6697 A truncated immunoglobulin E pseudogene is found in gorilla and man IgM RNA switch from membrane to secretory form is prevented by but not in chimpanzee, 3712 adding antireceptor antibody to bacterial lipopolysaccharide-stimulhted Immunoglobulin evolution murine primary B-cell cultures, 7384 Immunoglobulin VH gene structure and diversity in Heterodontus, a Immunoglobulln M mRNA phylogenetically primitive shark, 2082 Role of an RNA cleavage/poly(A) addition site in the production of mmunoglobulln G membrane-bound and secreted IgM mRNA, 8658 NZB mouse system for production of monoclonal antibodies to weak Immunogobuin -ain gene bacterial antigens: Isolation of an IgG antibody to the polysaccharide Specific 5' and 3' regions of the A-chain gene are undermethylated at capsules of Escherichia coli K1 and group B meningococci, 1194 distinct stages of B-cell differentiation, 3809 Immunoglobulin gene Immunoglobulln production Complete nucleotide sequences of three VH genes in Caiman, a Purification to homogeneity and characterization of human B-cell phylogenetically ancient reptile: Evolutionary diversification in coding differentiation factor (BCDF or BSFp-2), 5490 segments and variation in the structure and organization of recombination elements, 844 Immunoglobulin structure Human X light-chain constant region gene C)Mr: The primary structure Structural invariants of antigen binding: Comparison of immunoglobulin of XVI Bence Jones protein Mor, 3415 VL-VH and VL-VL domain dimers, 4592 Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and Immunoglobulin, surface IgA subclasses, 5495 Cross-reactive idiotypes and common antigen binding specificities Deletions of K chain constant region genes in mouse X chain-producing B expressed by a senes of murine B-cell lymphomas: Etiological cells involve intrachromosomal DNA recombinations similar to V-J implications, 3799 joining, 6211 Anti-immunogiobulin augments the B-cell antigen-presentation function independently of internalization of receptor-antigen complex, 5890 Immunoglobulin gene re nge t Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular Immunogiobuhin variable region lymphoma and demonstration of a breakpoint-cluster region near a Gene repertoire of the anti-poly(Glu6WAla3aTyriO) (GAT) immune transcriptionally active locus on chromosome 18, 7439 response: Comparison of VH, Vil, and D regions used by anti-GAT antibodies and monoclonal antibodies produced after anti-idiotypic Immunoglobulin heavy chain locus immunization, 4788 Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of line, 479 mouse T lymphocytes: Molecular homology to its human counterpart, Immunoglobulin JH, C,, and Cy gene rearrangements in human B Leu-2/T8, and to immunoglobulin variable regions, 5126 lymphocytes clonally transformed by Epstein-Barr virus, 556 Suppressor T-cell factor(s) display an altered pattern of Igh Immunoglobulin VH gene (immunoglobulin heavy chain locus) genetic restriction when developed Immunoglobulin VH gene structure and diversity in Heterodontus, a in an Igh-congeneic host, 2133 - phylogenetically primitive shark, 2082 Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome Immunological memory rearrangements in a murine plasmacytoma, 3746 Antigen induces chronic idiotype suppression, 4217 The c-myc oncogene is translocated to the involved chromosome 12 in Immunological tolerance mouse plasmacytoma, 4212 Acquired immunological tolerance of foreign cells is impaired by Deletion of a B-cell-specific enhancer affects transfected, but not recombinant interleukin 2 or vitamin A 536 endogenous, immunoglobulin heavy-chain gene expression, 5088 acetate, Gene localization on sorted chromosomes: Definitive evidence on the Immunomodulator relative positioning of genes participating in the mouse Parathymosin a: A peptide for rat tissues with structural homology to plasmacytoma-associated typical translocation, 6975 prothymosin a, 1050 Shared idiotopes among antibodies encoded by heavy-chain variable Cellular receptor for 125I-labeled tumor necrosis factor: Specific binding, region (VH) gene members of the J558 VH family as basis for affimity labeling, and relationship to sensitivity, 5756 cross-reactive regulation of clones with different antigen specificity, 7696 Immunophotoelectron microscopy Immunophotoelectron microscopy: The electron optical analog of Immunoglobuhin heavy chain variable region immunofluorescence microscopy, 109 Antigen-binding specificities of antibodies are primarily determined by Immunophotoelectron microscopy: The electron optical analog of seven residues of VH, 2945 immunofluorescence microscopy (Correction), 3062 Inmunoglobulin J chain Immunosuppression Secondary structure of the immunoglobulin J chain, 5905 Influence of the human T-lymphotropic virus/lymphadenopathy- associated virus on functions of human lymphocytes: Evidence for Immunoglobulin w chain immunosuppressive effects and polyclonal B-cell activation by banded Possible involvement of human D minigenes in the first viral preparations, 8198 complementarity-determining region of K light chains, 2125 Inducible transcription of the unrearranged K constant region locus is a Immunosurveillance common feature of pre-B cells and does not require DNA or protein Natural killer cell recognition of target cells expressing different antigens synthesis, 5305 of vesicular stomatitis virus, 2456 Preferential rearrangement of the immunoglobulin K chain joining region Molecular characterization of novel H-2 class I molecules expressed by a JK1 and JK2 segments in mouse spleen DNA, 6399 C3H UV-induced fibrosarcoma, 5485 cDNA of the immunoglobulin K chain of an Epstein-Barr virus-transformed human lymphoid cell line: Partial sequence Immunotherapy determination and bacterial expression, 7025 Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: A phase I Multiple-alphabet amino acid sequence comparisons of the trial in patients with malignant melanoma, 1242 immunoglobulin K-chain constant domain, 8597 Indoleaceic acid gene Immunoglohulin Kchain gene Nucleotide sequences of the Pseudomonas savastanoi indoleacetic acid Double recombination of a single immunoglobulin K-chain allele: genes show homology with Agrobacterium tumefaciens T-DNA, 6522 Implications for the mechanism of rearrangement, 4793 Deletions of K chain constant region genes in mouse X chain-producing B Infant cells involve intrachromosomal DNA recombinations similar to V-J How infant and mother jointly contribute to developing cognitive joining, 6211 competence in the child, 7470 Immunoglobulin X-chain Infection, viral Deletions of K chain constant region genes in mouse X chain-producing B An alternative route of infection for viruses: Entry by means of the cells involve intrachromosomal DNA recombinations similar to V-J asialoglycoprotein receptor of a Sendai virus mutant lacking its joining, 6211 attachment protein, 978 8892 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Inflammation Insertion element Chemical synthesis of a gene encoding the human complement fragment Highly structured sequence homology between an insertion element and C5a and its expression in Escherichia coli, 3543 the gene in which it resides, 493 Oxidant-dependent metabolic activation of polycyclic aromatic Nodulin-24 gene of soybean codes for a peptide of the peribacteroid hydrocarbons by phorbol ester-stimulated human polymorphonuclear membrane and was generated by tandem duplication of a sequence leukocytes: Possible link between inflammation and cancer, 5194 resembling an insertion element, 4157 Nodulin-24 gene of soybean codes for a peptide of the peribacteroid Influenza virus membrane and was generated by tanden duplication of a sequence Influenza A virus nucleoprotein is a major target antigen for resembling an insertion element (Correction), 6366 cross-reactive anti-influenza A virus cytotoxic T lymphocytes, 1785 Influenza viral (A/WSN/33) hemagglutinin is expressed and glycosylated Insertion in the yeast Saccharomyces cerevisiae, 2019 Two-codonmutapenesisinsertion mutagenesis of plasmid genes by using Expression of a functional influenza viral cap-recognizing protein by single-stranded hexameric oligonucleotides, 4202 using a bovine papilloma virus vector, 4326 Fusion of influenza virus membranes with liposomes at pH 7.5, 4611 Insulin Glucose increases the synthesis of lipoxygenase-mediated metabolites of Information processing arachidonic acid in intact rat islets, 198 Model of cortical organization embodying a basis for a theory of Evidence that a 90-kDa phosphoprotein, an associated kinase, and a information processing and memory recall, 2364 specific phosphatase are involved in the regulation of Cloudman Inhibin melanoma cell proliferation by insulin, 1007 Human seminal a inhibins: Isolation, characterization, and Hybrid molecules containing the B-domain of insulin-like growth factor I structure, 4041 are recognized by carrier proteins of the growth factor, 3010 Isolation and partial characterization of a Mr 32,000 protein with inhibin Insulin-stimulated glucose uptake in rat diaphragm during postnatal activity from porcine follicular fluid, 7217 development: Lack of correlation with the number of insulin receptors and of intracellular glucose transporters, 3621 Initiation Insulin-related genes expressed in human placenta from normal and Initiation of DNA replication on single-stranded DNA templates diabetic pregnancies, 3868 catalyzed by purified replication proteins of bacteriophage X and Induction of ornithine decarboxylase activity by insulin and growth Escherichia coli, 3988 factors is mediated by amino acids, 4365 Initiator tRNA may recognize more than the initiation codon in mRNA: Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol A model for translational initiation, 4587 ester, 4369 Epidermal growth factor stimulates glycogen synthase activity in cultured Initiation codon cells, 4563 Direct mapping of adeno-associated virus capsid proteins B and C: A Phorbol 12-myristate 13-acetate and insulin increase the concentration of possible ACG initiation codon, 7919 fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts, 6440 Initiation factor 2 Insulin, insulin-like growth factor II, and nerve growth factor effects on GTP-binding membrane protein of Escherichia coli with sequence tubulin mRNA levels and neurite formation, 7126 homology to initiation factor 2 and elongation factors Tu and G, 7500 Targeting of loaded Sendai virus envelopes by covalently attached insulin Initiation factor 2, eukaryotic molecules to virus receptor-depleted cells: Fusion-mediated Translational control by adenovirus: Lack of virus-associated RNA, microinjection of ricin A and simian virus 40 DNA, 7309 during adenovirus infection results in phosphorylation of initiation Mechanism of insulin action on membrane protein recycling: A selective factor eIF-2 and inhibition of protein synthesis, 1959 decrease in the phosphorylation state of insulin-like growth factor TI Adenovirus VAI RNA prevents phosphorylation of the eukaryotic receptors in the cell surface membrane, 7314 initiation factor 2 a subunit subsequent to infection, 4321 Nasal absorption of insulin: Enhancement by hydrophobic bile salts, 7419 Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction Initiation-promotion sequence during development and in response to glucocorticoids and Focal smooth muscle proliferation in the aortic intima produced by an insulin, 8242 initiation-promotion sequence, 3450 Induction of ornithine decarboxylase activity by insulin and growth Initiator protein factors is mediated by amino acids (Correction), 8274 Mutations in direct repeat sequences and in a conserved sequence Insulin gene adjacent to the repeats result in a defective replication origin in plasmid R6K, 1480 Homology requirements for recombination in Escherichia coli, 4768 Replication initiator protein of plasmid R6K autoregulates its own Isolation-of the human insulin-like growth factor genes: Insulin-like synthesis at the transcriptional step, 2574 growth factor II and insulin genes are contiguous, 6450 Innervation Insulin-like activity The all-or-none role of innervation in expression of apamin receptor and Biosynthetic 20-kilodalton methionyl-human growth hormone has of apamin-sensitive Ca2+-activated K+ channel in mammalian skeletal diabetogenic and insulin-like activities, 4250 muscle, 2188 Insulin-like growth factor Inositol cyclic phosphate Insulin-like growth factor II (TGF II) in human brain: Regional Inositol cyclic phosphates are produced by cleavage of distribution of IGF II and of higher molecular mass forms, 2153 phosphatidylphosphoinositols (polyphosphoinositides) with purified Hybrid molecules containing the B-domain of insulin-like growth factor I sheep seminal vesicle phospholipase C enzymes, 4013 are recognized by carrier proteins of the growth factor, 3010 Amino acid sequence of a variant pro-form of insulin-like growth factor Inositol phosphate II, 3169 Lithium induces corticotropin secretion and desensitization in cultured Linkage map of the short arm of human chromosome 11: Location of the anterior pituitary cells, 1286 genes for catalase, calcitonin, and insulin-like growth factor II, 5064 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of Heparin-treated, v-myc-transformed chicken heart mesenchymal cells inositol phosphates in human platelets: Possible implications for assume a normal morphology but are hypersensitive to epidermal negative feedback regulation of inositol phospholipid hydrolysis, 2623 growth factor (EGF) and brain fibroblast growth factor (bFGF); cells Pertussis toxin inhibits chemotactic peptide-stimulated generation of transformed by the v-Ha-ras oncogene are refractory to EGF and inositol phosphates and lysosomal enzyme secretion in human bFGF but are hypersensitive to insulin-like growth factors, 5781 leukemic (HL-60) cells, 3277 Insulin, insulin-like growth factor II, and nerve growth factor effects on 4iositol phospholipid tubulin mRNA levels and neurite formation, 7126 Phorbol esters promote a1-adrenergic receptor phosphorylation and Growth hormone and insulin-like growth factors I and HI produce distinct receptor uncoupling from inositol phospholipid metabolism, 5651 alterations in glucose metabolism in 3T3-F442A adipocytes, 8724 Inositol trisphosphate Insulin-like growth factor gene Inositol trisphosphate modification of ion transport in rough endoplasmic Isolation of the human insulin-like growth factor genes: Insulin-like reticulum, 4433 growth factor II and insulin genes are contiguous, 6450 Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle, 5231 Insulin-like growth factor U receptor Inositol 1,4,5-trisphosphate: A possible chemical link in Mechanism of insulin action on membrane protein recycling: A selective excitation-contraction coupling in muscle, 6352 decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane, 7314 Insect Characterization of octopamine-sensitive adenylate cyclase: Elucidation Insulin receptor of a class of potent and selective octopamine-2 receptor agonists with The monomeric a.8 form of the insulin receptor exhibits much higher toxic effects in insects, 599 insulin-dependent tyrosine-specific protein kinase activity than the Developmental expression of nuclear genes that encode mitochondrial intact a~A$ form of the receptor, 6095 proteins: Insect cytochromes c, 1964 An antipeptide antibody that specifically inhibits insulin receptor Insect cell autophosphorylation and protein kinase activity, 7899 Modification and secretion of human interleukin 2 produced in insect Expression of a functional human insulin receptor from a cloned cDNA cells by a baculovirus expression vector, 8404 in Chinese hamster ovary cells, 8014 Identification of a novel receptor in Drosophila for both epidermal Insect immunity growth factor and insulin, 8443 Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin Molecular association between major histocompatibility complex class I B from Hyalophora cecropia, 2240 antigens and insulin receptors in mouse liver membranes, 8634 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8893

Interferon A viral long terminal repeat in the interleukin 2 gene of a cell line that Interferon is a mediator of hematopoietic suppression in aplastic anemia constitutively produces interleukin 2, 7284 in vitro and possibly in vivo, 188 Regulation of expression of the human interferon y gene, 8173 Identification of individual interferon-producing cells by in situ Modification and secretion of human interleukin 2 produced in insect hybridization, 1136 cells by a baculovirus expression vector, 8404 Interferon stimulates cholesterol and phosphatidylcholine synthesis but Induction and upregulation by interleukin 2 of high-affinity interleukin 2 inhibits cholesterol ester synthesis in HeLa-S3 cells, 2417 receptors on thymocytes and T cells, 8663 Mouse major histocompatibility class I gene expression begins at Human T-cell growth factor (interleukin 2) and y-interferon genes: midsomite stage and is inducible in earlier-stage embryos by Expression in human T-lymphotropic virus type III- and type I-infected interferon, 2427 cells, 8691 Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein Interleukin 2 receptor kinase in human cells, 4341 Interleukin 2 receptor gene expression in normal human T Close linkage of a and P interferons and infrequent duplication of is lymphocytes, 6281 interferon in humans, 4473 Increased rate of degradation of c-myc mRNA in interferon-treated Daudi Interleukin 3 cells, 4896 Structure of the chromosomal gene for murine interleukin 3, 316 Production and characterization of a monoclonal antibody to a human Interleukin 3 promotes erythroid burst formation in "serum-free" cultures interferon-induced double-stranded RNA-binding Mr 68,000 protein without detectable erythropoietin, 3291 kinase, 4959 Correlation of cell-surface phenotype with the establishment of Unusual apparently constitutive interferons and antagonists in human interleukin 3-dependent cell lines from wild-mouse murine leukemia placental blood, 5010 virus-induced neoplasms, 6687 Mechanism of calcium ionophore A23187-induced priming of bone Interleukin 2-dependent release of interleukin 3 activity by T41 human marrow-derived macrophages for tumor cell killing: Relationship to T-cell clones, 7020 priming by interferon, 5959 Enrichment of hematopoietic precursor cells and cloning of multipotential Inhibitory effects of interferon on the expression of genes regulated by B-lymphocyte precursors, 7414 platelet-derived growth factor, 7608 Intermediate filament Interferon antagonist Isolation of the non-glycosylated proteins of desmosomes and in human immunolocalization of a third plaque protein: Desmoplakin III, 810 Unusual apparently constitutive interferons and antagonists Complete sequence of a gene encoding a human type I keratin: placental blood, 5010 Sequences homologous to enhancer elements in the regulatory region Interferon jS of the gene, 1609 Interferon regulates c-myc gene expression in Daudi cells at the Structure of a gene for the human epidermal 67-kDa keratin, 1896 post-transcriptional level, 1151 Differential expression of intermediate filament proteins distinguishes Significance of similarities in patterns: An application to , classic from variant small-cell lung cancer cell lines, 4409 interferon-related DNA on human chromosome 2, 4090 The sequence of a type II keratin gene expressed in human skin: Conservation of structure among all intermediate filament genes, 4683 Interferon-j3 receptor Identification of a distinct soluble subunit of an intermediate filament Murine interferon-a8 receptor-mediated endocytosis and nuclear protein: Tetrameric vimentin from living cells, 7929 membrane binding, 3281 Intermolecular contact Interferon y Influence of solvent accessibility and intermolecular contacts on atomic Biological activity of liposome-encapsulated murine interferon y is mobilities in hemerythrins, 1104 mediated by a cell membrane receptor, 3688 Expression of histocompatibility antigens H-2K, -D, and -L is reduced in Intertidal zone adenovirus-12-transformed mouse cells and is restored by interferon Larval settlement rate: A leading determinant of structure in an y, 5525 ecological community of the marine intertidal zone, 3707 Requirement of endogenous interferon-y production for resolution of Listeria monocytogenes infection, 7404 Intervening sequence Administration of recombinant interferon y to cancer patients enhances See also Intron monocyte secretion of hydrogen peroxide, 8686 Secondary structure of the circular form of the Tetrahymena rRNA Human T-cell growth factor (interleukin 2) and -interferon genes: intervening sequence: A technique for RNA structure analysis using virus III- and I-infected chemical probes and reverse transcriptase, 648 Expression in human T-lymphotropic type type Structure of a- human histone cDNA: Evidence that basally expressed cells, 8691 histone genes have intervening sequences and encode polyadenylylated Interferon y gene mRNAs, 2834 Regulation of expression of the human interferon y gene, 8173 Insertion of an unstable element in an intervening sequence of maize Adhl affects transcription but not processing, 2875 a-Interferon gene mRNA precursor splicing in vivo: Sequence requirements determined by Sequence directed mutagenesis: Evidence from a phylogenetic history of deletion analysis of an intervening sequence, 2885 human a-interferon genes, 8577 Specific regions of the intervening sequences of P-globin RNA are resistant to nuclease in 50S heterogeneous nuclear RNA-protein Interferon-producing cell complexes, 8414 Identification of individual interferon-producing cells by in situ hybridization, 1136 Intestine Depletion of mucosal mast cell protease by corticosteroids: Effect on Interleukin 1 intestinal anaphylaxis in the rat, 1214 Identification of a membrane-associated interleukin 1 in Cell-specific immunohistochemical localization of a cellular macrophages, 1204 retinol-binding protein (type two) in the small intestine of rat, 4707 Identification and partial characterization of hepatocyte-stimulating factor Human placental alkaline phosphatase in liver and intestine, 6080 from leukemia cell lines: Comparison with interleukin 1, 1443 Xenogeneic antiserum to soluble products from activated lymphoid cells Intracisternal A particle inhibits interleukin 1-mediated functions in the helper pathway of Expression of a mouse long terminal repeat is cell cycle-linked, 1946 cytolytic-effector-cell differentiation, 1513 Pure brain-derived acidic fibroblast growth factor is a potent angiogenic Intron vascular endothelial cell mitogen with sequence homology to See also Intervening sequence interleukin 1, 6409 Nucleotide sequence of the satellite of peanut stunt virus reveals Monoclonal antibodies against human Ia antigens stimulate monocytes to structural homologies with viroids and certain nuclear and secrete interleukin 1, 6652 mitochondrial intro'ns, 3110 Interleukin 1 can act as a B-cell growth and differentiation factor, 8153 Organization of the human transferrin gene: Direct evidence that it originated by gene duplication, 3149 Interleukin 2 Intron sequences reveal evolutionary relationships among major See also T-cell growth factor histocompatibility complex class I genes, 5860 Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: Expression of T-cell growth-factor activity after Intron boundary transfection of monkey cells, 68 Tobacco chloroplast tRNALYS(UUU) gene contains a 2.5-kilobase-pair Acquired immunological tolerance of foreign cells is impaired by intron: An open reading frame and a conserved boundary sequence in recombinant interleukin 2 or vitamin A acetate, 536 the intron, 3557 Interleukin 2 regulates its own receptors, 864 Affinity-purified interleukin 2 induces proliferation of large but not small Intron-exon junction B cells, 1518 Complete sequence of the chicken glyceraldehyde-3-phosphate Human T-lymphocyte response in vitro to synthetic peptides of herpes dehydrogenase gene, 1628 simplex virus glycoprotein D, 3425 Intron/exon arrangement Interleukin 2 (IL-2) augments transcription of the IL-2 receptor Nucleotide sequence and organization of the mouse adenine gene, 4230 phosphoribosyltransferase gene: Presence of a coding region common Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- to animal and bacterial phosphoribosyltransferases that has a variable thymocytes, 6268 intron/exon arrangement, 2731 Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2, 6932 Invasiveness Interleukin 2-dependent release of interleukin 3 activity by T4' human Invasiveness and ploidy of human mammary carcinomas in short-term T-cell clones, 7020 culture, 1805 8894 Subject Index Pr(oc. Nati. Acad. Sci. USA 82 (1985)

Inverted repeat Iron(IV)-oxo porphyrin Inversely epeating integrated hepatitis B virus DNA and cellular flanking Stabilization of higher-valent states of iron porphyrin by hydroxide and sequences in the human hepatoma-derived cell line huSP, 208 methoxide ligands: Electrochemical generation of iron(IV)-oxo Cleavage of cruciform DNA structures by an activity from porphyrins, 4301 Saccharomyces cerevisiae, 6445 IS' Invertible element Transposable element IS] intrinsically generates target duplications of An invertible element of DNA controls phase variation of type 1 fimbriae variable length, 839 of Escherichia coli, 5724 Ischemia Iodide Coronary thrombolysis with facilitated absorption of intramuscularly Thyrotropin upregulates a,-adrenergic receptors in rat FRTL-5 thyroid injected tissue-type plasminogen activator, 4258 cells, 8677 Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy, 8747 Iodlne-125 Scintillation proximity radioimmunoassay utilizing 125I-labeled Islets of Langerhans ligands, 8672 Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets, 198 Iodopindolol Processing of an anglerfish somatostatin precursor to a Rat Sertoli cells acquire a P-adrenergic response during primary hydroxylysine-containing somatostatin 28, 277 culture, 2049 Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: Implications for human Ion channel diabetes, 1544 Topological mapping of acetylcholine receptor: Evidence for a model Plasma and cellular retinoid-binding proteins and transthyretin with live transmembrane segments and a cytoplasmic COOH-terminal (prealbumin) are all localized in the islets of Langerhans in the peptide, 626 rat, 2488 Anomalous interaction of the acetylcholine receptor protein with the nonionic detergent Triton X-114, 958 2-Isobutyl-3-methoxypyrazine y-Aminobutyric acid receptor channels in adrenal chromaffin cells: A Isolation and characterization of an olfactory receptor protein for odorant patch-clamp study, 2168 pyrazines, 3050 Myasthenic serum selectively blocks acetylcholine receptors with long channel open times at developing rat endplates, 2533 Isoelectric focusing, immobilized gradient Single anion-selective channels in basolateral membrane of a mammalian Detection of neutral amino acid substitutions in proteins, 7646 tight e ithelium, 7791 Purified Iens junctional protein forms channels in planar lipid films, 8468 Isoform Interaction of hydrolysis-resistant analogs of cyclic GMP with the Cloning of Ly-5 cDNA, 7360 phosphodiesterase and light-sensitive channel of retinal rod outer Isopentenyladenosine segments, 8813 Presence and source of free isopentenyladenosine in yeasts, 1113 Ion etching Isoreceptor Ion etching of bacteriophage T4: Support for a spiral-fold model of Molecular comparison of a,- and a2-adrenergic receptors suggests that packaged DNA, 7960 these proteins are structurally related "isoreceptors", 4842 Ion movement Isotype-switch variant Correlation of ouabain-sensitive ion movements with cell-cycle Isolation and characterization of anti-monosialoganglioside monoclonal activation, 1599 antibody 19-9 class-switch variants, 8653 Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: Role of G proteins in excitation response Isotype switching coupling, 2708 B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA/9 mice do not provide Ion pump evidence for isotype switching without gene deletion, 511 Incorporation of membrane potential into theoretical analysis of Immunoglobulin gene rearrangements and deletions in human electrogenic ion pumps, 6869 Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses, 5495 Ion selectivity The Ca channel in skeletal muscle is a large pore, 7149 Isovaleric acidemia Molecular heterogeneity of variant isovaleryl-CoA dehydrogenase from Ion transport cultured isovaleric acidemia fibroblasts, 7081 23Na and 39K NMR studies of ion transport in human erythrocytes, 1099 Application of the principle of linked functions to ATP-driven ion pumps: Isovaleryl-CoA dehydrogenase Kinetics of activation by ATP, 3658 Molecular heterogeneity of variant isovaleryl-CoA dehydrogenase from Inositol trisphosphate modification of ion transport in rough endoplasmic cultured isovaleric acidemia fibroblasts, 7081 reticulum, 4433 Variable stoichiometry in active ion transport: Theoretical analysis of Isozyme physiological consequences, 5352 Two tissue-specific isozymes of creatine kinase have closely matched amino acid sequences, 2310 Ir gene Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2, 3771 Analysis of antigen presentation by metabolically inactive accessory cells Identification of three classes of cytosolic glutathione transferase and their isolated membranes, 6647 common to several mammalian species: Correlation between structural data and enzymatic properties, 7202 Iron r-ADH is the sole alcohol dehydrogenase isozyme of mammalian brains: Nonenzymatic sequence-specific cleavage of single-stranded DNA, 963 Implications and inferences, 8369 Sequence-specific cleavage of single-stranded DNA: Oligodeoxy- Cloning, sequencing, and chromosomal localization of human term nucleotide-EDTA.Fe(II), 968 placental alkaline phosphatase cDNA, 8715 Sequence-specific cleavage of single-stranded DNA: Oligo- deoxynucleotide-EDTA.Fe(II) (Correction), 3532 j-modulatlon Reduction of mammalian ferritin, 3640 1H homonuclear editing of rat brain using semiselective pulses, 3115 Transferrin receptors in rat brain: Neuropeptide-like pattern and Jaundice relationship to iron distribution, 4553 The liver excretes large amounts of heme in bile when heme oxygenase is Iron-molybdenum cofactor inhibited competitively by Sn-protoporphyrin, 896 Azotobacter vinelandii nfD- and n#E-encoded polypeptides share JC virus structural homology, 5720 Establishment of a line of human fetal glial cells that supports JC virus Iron-nickelm-carbon complex multiplication, 1257 Evidence that an iron-nickel-carbon complex is formed by reaction of Jigsaw-puzzle analogy CO with the CO dehydrogenase from Clostridium thermo- 4028 aceticum, 6811 Is there a single pathway for the folding of a polypeptide chain?, Johne disease Iron, nonheme A glycolipid antigen specific to Mycobacterium paratuberculosis: Active site structures of deoxyhemerythrin and oxyhemerythrin, 713 Structure and antigenicity, 3068 Iron protein, nitrogenase Joining region Covalent modification of the iron protein of nitrogenase from Pre erential rearrangement of the immunoglobulin K chain joining region Rhodospirillum rubrum by adenosine diphosphoribosylation of a Jhi and Jazz segments in mouse spleen DNA, 6399 specific arginine residue, 3173 cDNA of the immunoglobulin K chain of an Epstein-Barr virus-transformed human lymphoid cell line: Partial sequence Iron-sulfur protein determination and bacterial expression, 7025 Cloning and nucleotide sequence determination of the Clostridium pasteurianum ferredoxin gene, 1653 Juvenile hormone [4Fe-4S]-cluster-depleted Azotobacter vinelandii ferredoxin I: A new 3Fe High specific activity enantiomerically enriched juvenile hormones: iron-sulfur protein, 5661 Synthesis and binding assay, 5290 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8895

Juxtaglomerular cell Kluyveromyces lacis Isolation of renin-producing human cells by transfection with three Construction of strains of Saccharomyces cerevisiae that grow on simian virus 40 mutants, 8503 lactose, 7909 Kadomtsev-Petviashvili equation Knot Constants and pseudo-constants of the Kadomtsev-Petviashvili Genetic rearrangement of DNA induces knots with a unique topology: equation, 5242 Implications for the mechanism of synapsis and crossing-over, 3124 Kadsurenone korA gene Characterization of a platelet-activating factor receptor antagonist korA function of promiscuous plasmid RK2: An autorepressor that isolated from haifenteng (Piperfutokadsura): Specific inhibition of in inhibits expression of host-lethal gene kilA gene and replication gene vitro and in vivo platelet-activating factor-induced effects, 672 trfA, 7374 Kainate Kpn I family Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to "Retroposon" insertion into the cellular oncogene c-myc in canine kainate, 1837 transmissible venereal tumor, 1054 Kallikrein Krakt Human plasma kallikrein and CT inhibitor form a complex possessing an Sex determination: A hypothesis based epitope thai is not detectable on the parent molecules: Demonstration on noncoding DNA, 1165 using a monoclonal antibody, 5190 Kuru The 200- and 150-kDa neurofilament proteins react with IgG Karyotype autoantibodies from patients with kuru, Creutzfeldt-Jakob disease, and An electrophoretic karyotype for yeast, 3756 other neurologic diseases, 3485 Kaurene glycoside The 200- and 150-kDa neurofilament proteins react with IgG activated the autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob Metabolically steviol, aglycone of stevioside, is disease; A 62-kDa neurofilament-assqciated protein reacts with sera mutagenic, 2478 from sheep with natural scrapie, 3894 KB carcinoma cell Multiply drug-resistant human KB carcinoma cells have decreased L function amounts of a 75-kDa and a 72-kDa glycoprotein, 2330 Maass cusp forms, 3533 Keloid LI repeated sequences Altered steady-state ratio of type I/III procollagen mRNAs correlates LI sequences in HeLa extrachromosomal circular DNA: Evidence for with selectively increased type I procollagen biosynthesis in cultured circularization by homologous recombination, 1989 keloid fibroblasts, 5935 La antigen Keratin Isolation and analysis of cDNA clones expressing human lupus La Complete sequence of a gene encoding a human type I keratin: antigen, 2115 Sequences homologous to enhancer elements in the regulatory region of the gene, 1609 lac promoter Structure of a gene for the human epidermal 67-kDa keratin, 18% Rapid "footprinting" on supercoiled DNA, 3078 Mutagenesis of the lac promoter region in M13 mplO phage DNA by Keratin gene 4'-hydroxymethyl-4,5',8-trimethylpsoralen, 7355 The sequence of a type II keratin gene expressed in human skin: Conservation of structure among all intermediate filament genes, 4683 lacA gene Epidermal keratin gene expressed in embryos of Xenopus laevis, 5413 DNA sequence of the lactose operon: The lacA gene and the Keratin gene expression in simian virus 40-transformed human transcriptional termination region, 6414 keratinocytes, 8498 Laccase Keratinocyte Low-temperature magnetic circular dichroism studies of native laccase: Cell size as a determinant of the clone-forming ability of human Spectroscopic evidence for exogenous ligand bridging at a trinuclear keratinocytes, 5390 copper active site, 3063 Kidney lad shuttle Thyroid hormones increase Na'-H+ exchange activity in renal brush The lacI shuttle: Rapid analysis of the mutagenic specificity of ultraviolet border membranes, 3606 light in human cells, 8606 Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy, 5963 Ren-J and Ren-2 loci are expressed in mouse kidney, 6196 Two-codon insertion mutagenesis of plasmid genes by using Intravenous cyclosporine activates afferent and efferent renal nerves and single-stranded hexameric oligonucleotides, 4202 causes sodium retention in innervated kidneys in rats, 8222 Regulatory components in Citrobacterfreundii ampC P-lactamase induction, 4620 Kidney disease Inhibition of thromboxane synthesis ameliorates the progressive kidney Lactate disease of rats with subtotal renal ablation, 193 'H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo, 1633 kiU gene 'H homonuclear editing of rat brain using semiselective pulses, 3115 korA function of promiscuous plasmid RK2: An autorepressor that A 1H NMR technique for observing metabolite signals in the spectrum of inhibits expression of host-lethal gene kilA gene and replication gene perfused liver, 5246 trfA, 7374 Adrenergic regulation of gluconeogenesis: Possible involvement of two mechanisms of signal transduction in a,-adrenergic action, 6727 Kilham rat virus Proteins tightly associated with the termini of replicative form DNA of Lactate dehydrogenase Kilham rat virus, an autonomous parvovirus, 8335 Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5, 5260 Kin discrimination Kin discrimination by worker honey bees in genetically mixed Lactose groups, 3058 Construction of strains of Saccharomyces cerevisiae that grow on Kin recognition lactose, 7909 Preimaginal learning as a basis of colony-brood recognition in the ant Lactose operon Cataglyphis cursor, 8545 DNA sequence of the lactose operon: The lacA gene and the Kin selection transcriptional termination region, 6414 Gene-culture coevolution: Models for the evolution of altruism with Lactose permease cultural transmission, 5814 Isolation and nucleotide sequencing of lactose carrier mutants that Kinetoplast transport maltose, 3959 A minimal ribosomal RNA: Sequence and secondary structure of the 9S kinetoplast ribosomal RNA from Leishmania 1401 lacY gene tarentolae, Site-specific mutagenesis of histidine residues in the lac permease of Kinetoplast DNA Escherichia coli, 6765 Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei, 3380 Lamin Nuclear lamins and peripheral nuclear antigens during fertilization and Kinsnse embryogenesis in mice and sea urchins, 4727 Novel activity of human angiotensin I converting enzyme: Release of the Change of karyoskeleton during spermatogenesis of Xenopus: Expression NH2- and COOH-terminal tripeptides from the luteinizing of lamin Liv, a nuclear lamina protein specific for the male germ hormone-releasing hormone, 1025 line, 6176 Kirromycin Lamina rara A second tRNA binding site on elongation factor Tu is induced while the Basement membrane heparan sulfate proteoglycans are concentrated in factor is bound to the ribosome, 3212 the laminae rarae and in podocytes of the rat renal glomerulus, 3296 8896 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Laminectomy Lethal mutation Membrane lipid changes in laminectomized and traumatized cat spinal A lethal deletion on mouse chromosome 7 affects regulation of cord, 7071 liver-cell-specific functions: Posttranscriptional control of serum B 2442 !Lmminin protein and transcriptional control of aldolase synthesis, Laminin binds specifically to sulfated glycolipids, 1306 Leu-2 antigen Laminin is associated with the "neurite outgrowth-promoting factors" Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of found in conditioned media, 2183 mouse T lymphocytes: Molecular homology to its human counterpart, The Clq subunit of the first component of complement binds to laminin: Leu-2/T8, and to immunoglobulin variable regions, 5126 A mechanism for the deposition and retention of immune complexes in basement membrane, 3824 Leucine Metabolism of retinoic acid and retinol during differentiation of F9 Periodicity of leucine and tandem repetition of a 24-amino acid segment embryonal carcinoma cells, 4658 in the primary structure of leucine-rich a2-giycoprotein of human serum, 1906 Lanthanum Cation binding by bacteriorhodopsin, 396 Leucine metabolism Molecular heterogeneity of variant isovaleryl-CoA dehydrogenase from Lariat RNA cultured isovaleric acidemia fibroblasts, 7081 Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit genes, 8349 L-Leucine methyl ester P-globin Regulation of cellular function by products of lysosomal enzyme activity: Larval hemolymph protein Elimination of human natural killer cells by a dipeptide methyl ester Ancient origin for Hawaiian Drosophilinae inferred from protein generated from L-leucine methyl ester by monocytes or comparisons, 4753 polymorphonuclear leukocytes, 2468 Latency Leukemia Activation of expression of latent Epstein-Barr herpesvirus after gene Cell-cycle-specific genes differentially expressed in human transfer with a small cloned subfragment of heterogeneous viral leukemias, 4463 DNA, 4085 Leukemia, acute myeloblastic Lateral flow Activation of an N-ras gene in acute myeloblastic leukemia through Electron microscopic observation of domain movement in reconstituted somatic mutation in the first exon, 879 erythrocyte membranes, 7304 Leukemia, acute myelogenous Leader peptide Isolation and analysis of the 21q+ chromosome in the acute myelogenous Arginine in the leader peptide is required for both import and proteolytic leukemia 8;21 translocation: Evidence that c-mos is not cleavage of a mitochondrial precursor, 4930 translocated, 464 Leader, mu Leukemia, acute nonlymphocytic Antitermination by both the promoter and the leader regions of an c-src is consistently conserved in the chromosomal deletion (20q) Escherichia coli ribosomal RNA operon, 5073 observed in myeloid disorders, 6692 Leader sequence Chromosomal localization and characterization of c-abl in the t(6;9) of A 5' spliced leader is added in trans to both a- and P-tubulin transcripts acute nonlymphocytic leukemia, 8742 in Trypanosoma brucei, 5695 Leukemia cell Human leukemia cell maturation induced by a T-cell lymphokine isolated Learning from medium conditioned by normal lymphocytes, 1209 Preimaginal learning as a basis of colony-brood recognition in the ant Identification and partial characterization of hepatocyte-stimulating factor Cataglyphis cursor, 8545 from leukemia cell lines: Comparison with interleukin 1, 1443 Learning mutant The receptor for immunoglobulin E on rat basophilic leukemia cells: Genetic dissection of Drosophila adenylate cyclase, 5992 Effect of ligand binding on receptor expression, 1522 Isolation and characterization of leukotriene C4 synthetase of rat Ledin basophilic leukemia cells, 8399 An alternative route of infection for viruses: Entry by means of the asialoglycoprotein receptor of a Sendai virus mutant lacking its Leukemia, chronic myelogenous attachment protein, 978 Cell lines and clinical isolates derived from Ph'-positive chronic myelogenous leukemia patients express c-abl proteins with a common Leech structural alteration, 1810 Inhibition of Ca2' conductance in identified leech neurons by benzodiazepines, 3935 Leukemia, myelomonocytic Specific expression of the human cellularfps/fes-encoded protein NCP92 Leishmania in normal and leukemic myeloid cells, 2379 Induction of heat shock and stress proteins in promastigotes of three Leishmania species, 4414 Leulkemia, T-cell Somatic rearrangement of T-cell antigen receptor gene in human T-cell Leishmania donovani malignancies, 1224 Protonmotive force-driven active transport of 1-glucose and L-proline in the protozoan parasite Leishmania donovani, 1716 Leukemi, thymus Structural analysis of TL genes of the mouse, 5475 Leishmania major Immunization with Leishmania receptor for macrophages protects mice Leukemia virus against cutaneous leishmaniasis, 5910 Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus, 3306 Leishmania tarentolae A minimal ribosomal RNA: Sequence and secondary structure of the 9S Leukemogenesis kinetoplast ribosomal RNA from Leishmania tarentolae, 1401 Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus, 3306 Leishmania tropica Limited proteolysis of the bifunctional thymidylate synthase- Leukocyte dihydrofolate reductase from Leishmania tropica, 7188 Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines, 859 Lens, eye On the nature of the 5-lipoxygenase reaction in human leukocytes: cAMP-dependent phosphorylation of bovine lens a-crystallin, 4712 Enzyme purification and requirement for multiple stimulatory The role of ascorbic acid in senile cataract, 7193 factors, 6040 On the nature of the 5-lipoxygenase reaction in human leukocytes: Lens fiber Characterization of a membrane-associated 7505 Phosphorylation of lens fiber cell membrane proteins, 653 stimulatory factor, Leukocyte, polymorphonuclear Lens junctional protein Identification and functional characterization of leukotriene B4 Purified lens junctional protein forms channels in planar lipid films, 8468 20-hydroxylase of human polymorphonuclear leukocytes, 2292 Lentivirus Regulation of cellular function by products of lysosomal enzyme activity: Slow, persistent replication of lentiviruses: Role of tissue macrophages Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or and macrophage precursors in bone marrow, 7086 polymorphonuclear leukocytes, 2468 LepA protein Oxidant-dependent metabolic activation of polycyclic aromatic GTP-binding membrane protein of Escherichia coli with sequence hydrocarbons by phorbol ester-stimulated human polymorphonuclear homology to initiation factor 2 and elongation factors Tu and G, 7500 leukocytes: Possible link between inflammation and cancer, 5194 Lesch-Nyhan syndrome Leukotriene Glial cells metabolically cooperate: A potential requirement for gene Leukotriene B5 is formed in human neutrophils after dietary replacement therapy, 6662 supplementation with icosapentaenoic acid, 1540 Generation of leukotrienes by human monocytes upon stimulation of Lethal load their ,8-glucan receptor during phagocytosis, 2751 Rapid change in mutation rate in a local population of Drosophila Leukotriene C4 as a mediator of luteinizing hormone release from rat melanogaster, 7671 anterior pituitary cells, 3834 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8897

On the nature of the 5-lipoxygenase reaction in human leukocytes: Linker-scanning mutant Enzyme purification and requirement for multiple stimulatory Adenovirus EIIA early promoter: Transcriptional control elements and factors, 6040 induction by the viral pre-early EIA gene, which appears to be Leukotriene C4 production by murine mast cells: Evidence of a role for sequence independent, 2230 extracellular leukotriene A4, 6632 Alteration of leukotriene release by macrophages ingesting Toxoplasma Lipase gondii, 6922 Enzyme-catalyzed processes in organic solvents, 3192 On the nature of the 5-lipoxygenase reaction in human leukocytes: Lipid A Characterization of a membrane-associated stimulatory factor, 7505 Macrophage activation by monosaccharide precursors of Escherichia coli Leukotriene B4 20-hydroxylase lipid A, 282 Identification and functional characterization of leukotriene B4 Protection against Gram-negative bacteremia and endotoxemia with 20-hydroxylase of human polymorphonuclear leukocytes, 2292 human monoclonal IgM antibodies, 1790 Lipid bilayer Leukotriene C4 synthetase Functional reconstitution of the purified brain sodium channel in planar Isolation and characterization of leukotriene C4 synthetase of rat lipid bilayers, 240 basophilic leukemia cells, 8399 Channels formed by botulinum, tetanus, and diphtheria toxins in planar Leutelnizing hormone-releasing hormone lipid bilayers: Relevance to translocation of proteins across Radioimmunoassay for 6-D>tryptophan analog of luteinizing membranes, 1692 hormone-releasing hormone: Measurement of serum levels after Direct measurement of the electrogenic activity of o-type cytochrome administration of long-acting microcapsule formulations, 1547 oxidase from Escherichia coli reconstituted into planar lipid bilayers, 2570 Lewis antigen Molecular packing and area compressibility of lipid bilayers, 6532 Characterization of Lewis antigens in normal colon and gastrointestinal Lipid fluctuation adenocarcinomas, 3552 Fast and slow orientational fluctuations in membranes, 2029 lexA gene Lipid monolayer Deletions within a hinge region of a specific DNA-binding protein, 2301 Evidence for conduction of protons along the interface between water Structural analysis of the umu operon required for inducible mutagenesis and a polar lipid monolayer, in Escherichia coli, 4336 3217 Lipid peroxide LexA protein Endothelial cell-derived chemotactic activity for mouse peritoneal Dual role for Escherichia coli RecA protein in SOS mutagenesis, 3325 macrophages and the effects of modified forms of low density lipoprotein, 5949 Lexitropsin The molecular origin of DNA-drug specificity in netropsin and Lipid phase transition distamycin, 1376 Intrinsic curvature hypothesis for biomembrane lipid composition: A role for nonbilayer lipids, 3665 Lie algebra Calculus of twisted vertex operators, 8295 Lipocyte Hepatic lipocytes: The principal collagen-producing cells of normal rat Ligand binding liver, 8681 The receptor for immunoglobulin E on rat basophilic leukemia cells: Effect of ligand binding on receptor expression, 1522 Lipoperoxide Thermodynamic and kinetic cooperativity in ligand binding to multiple Mechanism of activation of the heme-stabilized translational inhibitor of sites on a protein: Ca2+ activation of an ATP-driven Ca pump, 4688 reticulocyte lysates by calcium ions and phospholipid, 3119 Kinetics of carbon monoxide binding to phenobarbital-induced cytochrome P450 from rat liver microsomes: A simple bimolecular Lipopolysaccharide process, 4900 Macrophage activation by monosaccharide precursors of Escherichia coli lipid A, 282 Ligand bridging Protection against Gram-negative bacteremia and endotoxemia with Low-temperature magnetic circular dichroism studies of native laccase: human monoclonal IgM antibodies, 1790 Spectroscopic evidence for exogenous ligand bridging at a trinuclear IgM RNA switch from membrane to secretory form is prevented by copper active site, 3063 adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures, 7384 Ligation Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and Experimental resolution of cooperative free energies for the ten ligation nitrate in response to Escherichia coli lipopolysaccharide, 7738 states of human hemoglobin, 5347 Lipoprotein Light Isolation and characterization of an RNA-proteolipid complex associated Light regulation of the synthesis of the large subunit of with the malignant state in humans, 3455 ribulose-1,5-bisphosphate carboxylase in peas: Evidence for Human apolipoprotein B cDNA clone isolation and demonstration that translational control, 5690 liver apolipoprotein B mRNA is 22 kilobases in length, 6825 Mode of coaction between blue/UV light and light absorbed by A defect in cholesterol esterification in Niemann-Pick disease (type C) phytochrome in light-mediated anthocyanin formation in the milo patients, 8247 (Sorghum vulgare Pers.) seedling, 6124 Liposome Light, blue Biological activity of liposome-encapsulated murine interferon y is Kinetic properties of the blue-light response of stomata, 8019 mediated by a cell membrane receptor, 3688 Fusion of influenza virus membranes with liposomes at pH 7.5, 4611 Light-chain gene On the correlation between Hu phase and the contact-induced Human X light-chain constant region gene CxMor: The primary structure destabilization of phosphatidylethanolamine-containing of XVI Bence Jones protein Mor, 3415 membranes, 5742 Corticotropin releasing-factor-induced adrenocorticotropin hormone Light, circularly polarized release and synthesis is blocked by incorporation of the inhibitor of Imaging of optically active biological structures by use of circularly cyclic AMP-dependent protein kinase into anterior pituitary tumor cells polarized light, 401 by liposomes, 8261 Light-harvesting complex Lipoxin Light-harvesting II (B800-B850 complex) structural genes from On the nature of the 5-lipoxygenase reaction in human leukocytes: Rhodopseudomonas capsulata, 58 Enzyme purification and requirement for multiple stimulatory Light-harvesting chlorophyll a/a-protein: Three-dimensional structure of factors, 6040 a reconstituted membrane lattice in negative stain, 386 Lipoxygenase Limb bud Glucose increases the synthesis of lipoxygenase-mediated metabolites of Morphogenetic rearrangement of injected collagen in developing chicken arachidonic acid in intact rat islets, 198 limb buds, 2804 Inhibitors of the cytochrome P450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor Limulus cells, 1012 Statistical test of linearity of photoreceptor transduction process: Limulus Predominant generation of 15-lipoxygenase metabolites of arachidonic passes, others fail, 232 acid by epithelial cells from human trachea, 4633 On the nature of the 5-lipoxygenase reaction in human leukocytes: LINE-1 family Enzyme purification and requirement for multiple stimulatory Expression of a cytoplasmic LINE-1 transcript is regulated in a human factors, 6040 teratocarcinoma cell line, 6050 Leukotriene C4 production by murine mast cells: Evidence of a role for extracellular leukotriene A4, 6632 Linkage disequilibrium On the nature of the 5-lipoxygenase reaction in human leukocytes: Nucleotide sequence of an HLA-DQ a chain derived from a DRw9 cell Characterization of a membrane-associated stimulatory factor, 7505 line: Genetic and evolutionary implications, 3420 Use of pooled DNA samples to detect linkage disequilibrium of Listeria monocytogenes polymorphic restriction fragments and human disease: Studies of the Requirement of endogenous interferon-y production for resolution of HLA class II loci, 6970 Listeria monocytogenes infection, 7404 8898 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Lithium Lupus erythematosus Lithium induces corticotropin secretion and desensitization in cultured Isolation and analysis of cDNA clones expressing human lupus La anterior pituitary cells, 1286 antigen, 2115 Lithium perhydroantamanide complex (2:1): Exposure of the peptide Immunization of rabbits with purified RNA polymerase I induces a backbone in the analog of antamanide with antitoxic impotency, 7155 distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic Liver lupus erythematosus, 6797 Apolipoprotein E mRNA is abundant in the brain and adrenals, as well cDNA cloning of a human autoimmune nuclear ribonucleoprotein as in the liver, and is present in other peripheral tissues of rats and 7914 marmosets, 203 antigen, Inversely repeating integrated hepatitis B virus DNA and cellular flanking Luteinizing hormone sequences in the human hepatoma-derived cell line huSP, 208 Neuropeptide Y affects secretion of luteinizing hormone and growth The liver excretes large amounts of heme in bile when heme oxygenase is hormone in ovariectomized rats, 561 inhibited competitively by Sn-protoporphyrin, 896 Leukotriene C4 as a mediator of luteinizing hormone release from rat Dissociation from albumin: A potentially rate-limiting step in the anterior pituitary cells, 3834 clearance of substances by the liver, 1563 Expression of biologically active bovine luteinizing hormone in Chinese A lethal deletion on mouse chromosome 7 affects regulation of hamster ovary cells, 7280 liver-cell-specific functions: Posttranscriptional control of serum Cyclical secretion of prorenin during the menstrual cycle: protein and transcriptional control of aldolase B synthesis, 2442 Synchronization with luteinizing hormone and progesterone, 8705 Bone marrow engraftment efficiency is enhanced by competitive inhibition of the hepatic asialoglycoprotein receptor, 2508 Luteining hormone receptor A 1H NMR technique for observing metabolite signals in the spectrum of Inhibition of gonadotropin-induced granulosa cell differentiation by perfused liver, 5246 activation of protein kinase C, 8518 Human placental alkaline phosphatase in liver and intestine, 6080 Luteinizing hormone-releasing hormone Identification of an inducible form of cytochrome PA450 in human Novel activity of human angiotensin I converting enzyme: Release of the liver, 6310 NH2- and COOH-terminal tripeptides from the luteinizing Liver cell hormone-releasing hormone, 1025 Hepatic lipocytes: The principal collagen-producing cells of normal rat Inhibition of growth of a prolactin and growth hormone-secreting pituitary tumor in rats by D-tryptophan-6 analog of luteinizing liver, 8681 hormone-releasing hormone, 1252 Long interspersed repeated element Combination of long-acting microcapsules of the D-tryptophan-6 analog of Insertion of long interspersed repeated elements at the Igh luteinizing hormone-releasing hormone with chemotherapy: (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus Investigation in the rat prostate cancer model, 2498 integration 2) loci of rats, 2857 Luteinizing hormone-releasing hormone, D-tryptophan-6 analog Long terminal repeat D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a Hormonal response region in the mouse mammary tumor virus long protective agent against testicular damage caused by cyclophosphamide terminal repeat can be dissociated from the proviral promoter and has in baboons, 2975 enhancer properties, 1020 Luteotropin Expression of a mouse long terminal repeat is cell cycle-linked, 1946 Identification and partial characterization of a prolactin-like hormone Spatial distribution of transcripts of the long repeated ETn sequence produced by rat decidual tissue, 217 during early mouse embryogenesis, 2054 Functional activation of the long terminal repeat of human T-cell Lutropin leukemia virus type I by a trans-acting factor, 2277 Structural requirements for sulfation of asparagine-linked Isolation of embryonal carcinoma cell lines that express integrated oligosaccharides of lutropin, 7850 recombinant genes flanked by the Moloney murine leukemia virus long terminal repeat, 2422 Ly antigen Long terminal repeat sequences impart hematopoietic transformation The Ly-15 alloantigenic system: A genetically determined polymorphism properties to the myeloproliferative sarcoma virus, 5746 of the murine lymphocyte function-associated antigen-1 molecule, 526 Location of cis-acting regulatory sequences in the human T-cell leukemia Cloning of Ly-5 cDNA, 7360 virus type I long terminal repeat, 6502 Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG A viral long terminal repeat in the interleukin 2 gene of a cell line that Fc receptor, 7706 constitutively produces interleukin 2, 7284 Retrovirus-induced spongiform encephalopathy: The 3'-end long terminal Lycopersicon periwlnum repeat-containing viral sequences influence the incidence of the disease Gametophytic self-incompatibility is controlled by a single major locus on and the specificity of the neurological syndrome, 8818 chromosome 1 in Lycopersicon peruvianum, 5093 Longevity Lymnaea stagnalis Peroxide-producing potential of tissues: Inverse correlation with Purification and amino acid sequence of the ovulation neurohormone of longevity of mammalian species, 4798 Lymnaea stagnalis, 7767 Lymphadenopathy Loric Rationale for bone marrow transplantation in the treatment of A cosmid vector that facilitates restriction enzyme mapping, 3159 autoimmune diseases, 2483 Low density lipoprotein Lymphadenopathy-associated virus Unmodified low density lipoprotein causes cholesteryl ester accumulation See Human T-cell leukemia virus in J774 macrophages, 416 Interferon stimulates cholesterol and phosphatidylcholine synthesis but Lymphoblast inhibits cholesterol ester synthesis in HeLa-S3 cells, 2417 A third viral nuclear protein in lymphoblasts immortalized by Essential role of phospholipase A2 activity in endothelial cell-induced Epstein-Barr virus, 5944 modification of low density lipoprotein, 3000 Cloning and expression of apolipoprotein B, the major protein of low and Lymphoblastoid ceil line very low density lipoproteins, 4597 Production of antibody associated with non-A, non-B hepatitis in a Endothelial cell-derived chemotactic activity for mouse peritoneal chimpanzee lymphoblastoid cell line established by in vitro macrophages and the effects of modified forms of low density transformation with Epstein-Barr virus, 2138 lipoprotein, 5949 Lymphocyte Human apolipoprotein B-100: Cloning, analysis of liver mRNA, and A retrovirual myc gene induces preneoplastic transformation of assignment of the gene to chromosome 2, 8340 lymphocytes in a bursal transplantation assay, 222 Low density lipoprotein receptor Murine monoclonal antibodies to the myelin-associated glycoprotein react Dietary saturated triacylglycerols suppress hepatic low density with large granular lymphocytes of human blood, 552 lipoprotein receptor activity in the hamster, 4526 Human leukemia cell maturation induced by a T-cell lymphokine isolated Human genes involved in cholesterol metabolism: Chromosomal mapping from medium conditioned by normal lymphocytes, 1209 of the loci for the low density lipoprotein receptor and Characterization of the activation of Na+/H+ exchange in lymphocytes 3-hydroxy-3-methylgiutaryl-coenzyme A reductase with cDNA by phorbol esters: Change in cytoplasmic pH dependence of the probes, 8567 antiport, 1429 Lack of lymphocyte-induced DNA fragmentation in human targets during Low density lipoprotein receptor gene lysis represents a species-specific difference between human and Polymorphism and evolution of Alu sequences in the human low density murine cells, 4482 lipoprotein receptor gene, 7651 The regulation of DNA synthesis in quiescent lymphocytes by cytoplasmic inhibitors, 5160 Luciferase Expression of cell-cycle-dependent genes in phytohemagglutinin- Cloning of firefly luciferase cDNA and the expression of active luciferase stimulated human lymphocytes, 5375 in Escherichia coli, 7870 Complement-dependent cellular cytotoxicity: Lymphoblastoid lines that activate complement component 3 (C3) and express C3 receptors have Lung increased sensitivity to lymphocyte-mediated lysis in the presence of Structure of canine pulmonary surfactant apoprotein: cDNA and fresh human serum, 5470 complete amino acid sequence, 6379 Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: Delineation of antigenic determinants for Lupinus texensis encephalitogenicity, in vitro activation of cellular transfer, and Chloroplast DNA diversity is low in a wild plant, Lupinus texensis, 6950 proliferation of lymphocytes, 5515 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8899

Adenine ribo- and deoxyribonucleotide metabolism in human M protein erythrocytes, B- and T-lymphocyte cell lines, and monocyte- Relationship of M protein genes in group A streptococci, 1822 macrophages, 6682 Influence of the human T-lymphotropic virus/lymphadenopathy- Maas cusp form associated virus on functions of human lymphocytes: Evidence for Maass cusp forms, 3533 immunosuppressive effects and polyclonal B-cell activation by banded Macacafascicudais viral preparations, 8198 monkey cerebellum, 7131 Human monocyte-endothelial cell interaction in vitro, 8208 Diversity among Purkinje cells in the Macace mdata Lymphocyte function-associated antigen-i Dispersion of growing axons within the optic nerve of the embryonic The Ly-15 alloantigenic system: A genetically determined polymorphism monkey, 3906 of the murine lymphocyte function-associated antigen-i molecule, 526 Lymphokine Peptides from regenerating central nervous system promote specific Identification of a unique B-cell-stimulating factor produced by a cloned populations of macroglia, 4287 dendritic cell, 183 Affinity-purified interleukin 2 induces proliferation of large but not small arMacroglobulin B cells, 1518 Common evolutionary origin of a2-macroglobulin and complement B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, components C3 and C4, 9 provisional 1) is a differentiation factor for resting B cells and may not Nucleotide sequence of cDNA encoding human a2-macroglobulin and induce cell growth, 2465 assignment of the chromosomal locus, 2282 B-cell stimulatory factor 1 activates resting B cells, 2935 Model of a2-macroglobulin structure and function, 5700 Use of monoclonal antibodies to a human cytotoxin for its isolation and for examining the self-induction of resistance to this protein, 3814 Macromolecule motion Purification and characterization of a human T-lymphocyte-derived glial Normal modes for specific motions of macromolecules: Application to growth-promoting factor, 3930 the hinge-bending mode of lysozyme, 4995 Inhibition of soluble immune response suppressor activity by growth Mac age factors, 6260 Macrophage activation by monosaccharide precursors of Escherichia coli Requirement of endogenous interferon-y production for resolution of lipid A, 282 Listeria monocytogenes infection, 7404 Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor, 292 Lymphoma Unmodified low density lipoprotein causes cholesteryl ester accumulation Formation of a transformed follicle is necessary but not sufficient for in 1774 macrophages, 416 development of an avian leukosis virus-induced lymphoma, 213 Expression of the a1-proteinase inhibitor gene in human monocytes and Comparison of chemically induced and spontaneous murine thymic macrophages, 795 lymphomas in RF and AKR mice: Differential expression of c-myc and Identification of a membrane-associated interleukin 1 in c-myb, 565 macrophages, 1204 Identification of B cells in multilineage hematopoietic colonies derived Scavenger receptor-mediated recognition of maleyl bovine plasma from cells of patients with lymphocytic lymphoma, 883 albumin and the demaleylated protein in human monocyte Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular macrophages, 2693 lymphoma and demonstration of a breakpoint-cluster region near a Isolation of cDNA for a human granulocyte-macrophage transcriptionally active locus on chromosome 18, 7439 colony-stimulating factor by functional expression in mammalian Loss of the normal N-ras allele in a mouse thymic lymphoma induced by cells, 4360 a chemical carcinogen, 7810 Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: Evidence for the Lymphoma cell existence of a second mannose 6-phosphate receptor, 4428 Transcription of three c-myc exons is enhanced in chicken bursal Amino-terminal amino acid sequence of murine colony-stimulating factor lymphoma cell lines, 53 1, 4486 The translocated c-myc oncogene of Raji Burkitt lymphoma cells is not High-affinity-receptor-mediated uptake and degradation of expressed in human lymphoblastoid cells, 2900 glucose-modified proteins: A potential mechanism for the removal of senescent macromolecules, 5588 Lymphoprolferation Immunization with Leishmania receptor for macrophages protects mice Immunologic abnormalities of mice bearing the gid mutation suggest a against cutaneous leishmaniasis, 5910 common pathway for murine nonmalignant lymphoproliferative Eidothelial cell-derived chemotactic activity for mouse peritoneal disorders with autoimmunity, 1219 macrophages and the effects of modified forms of low density D-Lysergic acid diethylamide lipoprotein, 5949 a shock in the rabbit visual system, 1281 Mechanism of calcium ionophore A23187-induced priming of bone Axonal transport of heat protein marrow-derived macrophages for tumor cell killing: Relationship to Lysine priming by interferon, 5959 Lysine residue 121 in the proposed ATP-binding site of the v-mos protein Alteration of leukotriene release by macrophages ingesting Toxoplasma is required for transformation, 7894 gondii, 6922 Developmental regulation of c-myb in normal myeloid progenitor Lysosome cells, 6937 Castanospermine inhibits a-glucosidase activities and alters glycogen Slow, persistent replication of lentiviruses: Role of tissue macrophages distribution in animals, 93 and macrophage precursors in bone marrow, 7086 Isolation of cDNA clones coding for the 0 subunit of human Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and P-hexosaminidase, 1184 nitrate in response to Escherichia coli lipopolysaccharide, 7738 Identification of cDNA clones encoding a precursor of rat liver cathepsin Amino-terminal amino acid sequence of murine colony-stimulating factor B, 2320 1 (Correction), 7801 Lysosomotropic agents selectively potentiate thrombin-induced acid High-affinity-receptor-mediated uptake and degradation of hydrolase secretion from platelets, 2374 glucose-modified proteins: A potential mechanism for the removal of Regulation of cellular function by products of lysosomal enzyme activity: senescent macromolecules (Correction), 8274 Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or Macrophage cytotoxin polymorphonuclear leukocytes, 2468 Cellular receptor for 125I-labeled tumor necrosis factor: Specific binding, Pertussis toxin inhibits chemotactic peptide-stimulated generation of affinity labeling, and relationship to sensitivity, 5756 inositol phosphates and lysosomal enzyme secretion in human Macula adhaerens leukemic (HL-60) cells, 3277 Isolation of the non-glycosylated Proteins of desmosomes and Lysosomal enzyme binding to mouse P388D1 macrophage membranes immunolocalization of a third plaque protein: Desmoplakin III, 810 lacking the 215-kDa mannose 6-phosphate receptor: Evidence for the existence of a second mannose 6-phosphate receptor, 4428 --gesium Tumor necrosis factor: Specific bind and internalization in sensitive ation binding by bacteriorhodopsin, 396 and resistant cells, 7626 Importance of bound divalent cations to the tyrosine deprotonation Properties of the Syrian hamster phosphomannosyl receptor: An during the photocycle of bacteriorhodopsin, 3662 aggregate of low molecular weight proteins, 8379 Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis, 7324 Lysozyme A genetic screen for mutations that increase the thermal stability of Magnetic field phage T4 lysozyme, 747 Effect of magnetic fields on the triplet state lifetime in photosynthetic Normal modes for specific motions of macromolecules: Application to reaction centers: Evidence for thermal repopulation of the initial the hinge-bending mode of lysozyme, 4995 radical pair, 6850 Protonic conductivity of hydrated lysozyme powders at megahertz Magnetic moment frequencies, 5342 Comparison of the theoretical and experimental values of the number of Ia-transfected L-cell fibroblasts present a lysozyme peptide but not a metallic orbitals per atom in hypoelectronic and hyperelectronic native protein to lysozyme-specific T cells, 5885 metals, 8286 Lyt-2 antigen Maize Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of Nucleotide sequence of F0-ATPase proteolipid (subunit 9) gene of maize mouse T lymphocytes: Molecular homology to its human counterpart, mitochondria, 1015 Leu-2/T8, and to immunoglobulin variable regions, 5126 Maize mitochondria synthesize organ-specific polypeptides, 6879 8900 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Major histocompatibility antigen Maleness factor Molecular characterization of MT3 antigens by two-dimensional gel Sex determination: A hypothesis based on noncoding DNA, 1165 electrophoresis, NH2-terminal amino acid sequence analysis, and Is human X chromosome inactivation a sex-determining device?, 6947 Southern blot analysis, 3794 Human cytotoxic T-lymphocyte recognition of an HLA-A3 gene product Malondlaldelsyde low density lipoprotein expressed on murine L cells: The only human gene product required Scavenger receptor-mediated recognition of maleyl bovine plasma on the target cells for lysis is the class I heavy chain, 4490 albumin and the demaleylated protein in human monocyte macrophages, 2693 Major histocompatibility complex Characterization of an HLA DRP pseudogene, 1475 Maltose Characterization of a Q subregion gene in the murine major Isolation and nucleotide sequencing of lactose carrier mutants that histocompatibility complex, 1503 transport maltose, 3959 The PI domain of the mouse Ep chain is important for restricted antigen Mammary C oma presentation to helper T-cell hybridomas, 1678 Invasiveness and ploidy of human mammary carcinomas in short-term Allelic polymorphism and transassociation of molecules encoded by the culture, 1805 HLA-DQ subregion, 1776 Mouse major histocompatibility class I gene expression begins at Mammary gland midsomite stage and is inducible in earlier-stage embryos by Interaction of mouse mammary epithelial cells with collagen substrata: interferon, 2427 Regulation of casein gene expression and secretion, 1419 Evolution of mouse major histocompatibility complex genes borne by t chromosomes, 2819 Mammary tumor Evidence that polymorphism in the murine major histocompatibility Effect of dietary ascorbic acid on the incidence of spontaneous mammary complex may be generated by the assortment of subgene tumors in RIII mice, 5185 sequences, 2890 Evidence for the involvement of the submandibular gland epidermal Predicted protein sequence of the murine I-Els polypeptide chain from growth factor in mouse mammary tumorigenesis, 5940 cDNA and genomic clones, 2910 Man A molecular basis for the Ia.2 and Ia.19 antigenic determinants, 2930 Evidence for higher rates than in "Exon-shuffling" maps control of antibody- and T-cell-recognition sites to of nucleotide substitution in rodents the NH2-terminal domain of the class II major histocompatibility man, 1741 polypeptide 2940 Manduca sexta Molecular analysisAp, of an EL4 zell line that expresses H-2Db but not Developmental expression of nuclear genes that encode mitochondrial H-2Kb or P2-microglobulin, 2950 proteins: Insect cytochromes c, 1964 DNA sequence and characterization of human class II major histocompatibility complex P chains from the DR] haplotype, 3405 Manganese Gene organization of DC and DX subregions of the human major Molecular mechanism of water oxidation in photosynthesis based on the histocompatibility complex, 3410 functioning of manganese in two different environments, 6119 Chemosensory recognition of mouse major histocompatibility types by another species, 4186 Manifold, Grassmann Identification of a unique tumor-specific antigen as a novel class I major Harmonic maps of S2 into a complex Grassmann manifold, 2217 histocompatibility molecule, 5140 Mannitol Reactivation by a trans-acting factor of human major histocompatibility 13C NMR studies of carbon metabolism in the hyphal fungus Aspergillus complex Ia gene expression in interspecies hybrids between an nidulans, 14 Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma, 5145 Mannose Structural organization of the DR subregion of the human major Mutations in the phosphoglucose isomerase gene can lead to marked histocompatibility complex, 5165 alterations in cellular ATP levels in cultured fibroblasts exposed to "Exon-shuffling" maps control of antibody- and T-cell-recognition sites to simple nutrient shifts, 2761 the NH2-terminal domain of the class II major histocompatibility polypeptide An (Correction), 5236 Mannose 6-phosphate Exuberant restriction fragment length polymorphism associated with the Properties of the Syrian hamster phosphomannosyl receptor: An DQ a-chain gene and the DX a-chain gene, 5433 aggregate of low molecular weight proteins, 8379 The I region of the C57BL/10 mouse: Characterization and physical linkage to H-2K of an SB#-like class II pseudogene, D#AUB, 5500 Mannose 6-phosphate receptor Expression in L cells of transfected class I genes from the mouse major Lysosomal enzyme binding to mouse P388D1 macrophage membranes histocompatibility complex, 5505 lacking the 215-kDa mannose 6-phosphate receptor: Evidence for the Intron sequences reveal evolutionary relationships among major existence of a second mannose 6-phosphate receptor, 4428 histocompatibility complex class I genes, 5860 Map, harmonic Structure and expression of genes encoding murine Qa-2 class I of antigens, 5920 Harmonic maps 52 into a complex Grassmann manifold, 2217 Expression of hybrid class I genes of the major histocompatibility Marek disease virus complex in mouse L cells, 6245 The structure of Marek disease virus DNA: The presence of unique Evidence that major histocompatibility complex restriction of foreign expansion in nonpathogenic viral DNA, 751 transplantation antigens occurs when tolerance is induced in neonatal The structure of Marek disease virus DNA: The presence of unique mice and rats, 6265 expansion in nonpathogenic viral DNA (Correction), 5236 In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene Markoff-Duffin-Schaiffer inequality products, 6627 The Markoff-Duffin-Schaeffer inequalities abstracted, 955 Additional products of the Tla locus of the mouse, 7044 Identification of a polymorphic variant associated with HLA-DQw3 and Marmoset characterized by specific restriction sites within the DQ a-chain Apolipoprotein E mRNA is abundant in the brain and adrenals, as well gene, 8139 as in the liver, and is present in other peripheral tissues of rats and Class II major histocompatibility complex molecules regulate the marmosets, 203 development of the T4+T8- inducer phenotype of cultured human thymocytes, 8178 Marsupial Mutations that impair a posttranscriptional step in expression of HLA-A Cloning and chromosomal location of the a- and P-globin genes from a and -B antigens, 8183 marsupial, 8105 HLA-B locus polymorphism: Studies with a specific hybridization Mass spectrometry probe, 8614 Peptide mixture sequencing by tandem Fourier-transform mass Molecular association between major histocompatibility complex class I spectrometry, 6367 antigens and insulin receptors in mouse liver membranes, 8634 Mast cell Major Depletion of mucosal mast cell protease by corticosteroids: Effect on urinary protein intestinal anaphylaxis in the rat, 1214 Evolutionary amplification of a pseudogene, 4182 Selective internalization of granule membrane after secretion in mast cells, 1711 Malaria Homology of the rat basophilic leukemia cell and the rat mucosal mast Interspersed blocks of repetitive and charged amino acids in a dominant cell, 3871 immunogen of Plasmodium falciparum, 543 Antigen-induced increase in protein kinase C activity in plasma Oxidative stress and protective mechanisms in erythrocytes in relation to membrane of mast cells, 8193 Plasomodium vinckei load, 548 Expression of Plasmodium falciparum surface antigens in Escherichia Mast-cell growth factor coli, 2518 Structure of the chromosomal gene for murine interleukin 3, 316 A blood stage antigen of Plasmodium falciparum shares determinants with the sporozoite coat protein, 5121 Master equation Monkey-derived monoclonal antibodies against Plasmodium Anomalous properties of a simple small-volume membrane transport falciparum, 6272 system at steady state, 3654 Mastocytosis Male behavior Transformation of prostaglandin D2 to 9a,11-(15S)-trihydroxyprosta-(5Z, Synthetic pheromones that promote inter-male aggression in mice, 2059 13E)-dien-1-oic acid (9a,11P-prostaglandin F2): A unique biologically Brood care by male bumble bees, 6371 active prostaglandin produced enzymatically in vivo in humans, 6030 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8901

MAT gene Membrand fusion Control of yeast a-specific genes: Evidence for two blocks to expression On the correlation between Hu phase and the contact-induced in MATa/MATa diploids, 5855 destabilization of phosphatidylethanolamine-containing membranes, 5742 Maternally transmitted antigen Expression at the cell surface of biologically active fusion and Mitochondrial modulation of maternally transmitted antigen: Analysis of hemagglutinin/neuramnmidase proteins of the paramyxovirus simian cell hybrids, 3286 virus 5 from cloned cDNA, 7520 Matn tyPe Membrane glycoprotein Activation regions in a yeast transposon have homology to mating type Characterization of antigens recognized by monoclonal and polyclonal control sequences and to mammalian enhancers, 5423 antibodies directed against uvomorulin, 8067 Control of yeast a-specific genes: Evidence for two blocks to expression Correlation between fusion and the developmental regulation of in MA Ta/MATa diploids, 5855 membrane glycoproteins in L6 myoblasts, 8409 Matrix factorizatlon Membrane, influenza virus Solution of the embedding problem and decomposition of symmetric Fusion of influenza virus matrices, 2197 membranes with liposomes at pH 7.5, 4611 Membrane Internalization MC25 antigen Selective internalization of granule membrane after secretion in mast Cell surface antigen of human neuroblastomas is related to nuclear 1711 antigen of normal cells, 6894 cells, Membrane knob -t gene Membrane knobs are required for the microcirculatory obstruction Microdissection and microcloning of the mouse X chromosome, 5846 induced by Plasmodium falciparum-infected erythrocytes, 3829 Mean Membrane lattice Linear empirical Bayes estimation of means and variances, 1571 Light-harvesting chlorophyll a/a-protein: Three-dimensional structure of Measles virus a reconstituted membrane lattice in negative stain, 386 Natural history of restricted synthesis and expression of measles virus Membrane lipid genes in subacute sclerosing panencephalitis, 3020 Intrinsic curvature hypothesis for biomembrane lipid composition: A role for nonbilayer lipids, 3665 Mechanoreception Membrane lipid changes in laminectomized and traumatized cat spinal Flower petal microtexture is a tactile cue for bees, 4750 cord, 7071 Median eminence NH2-terminal specificity and axonal localization of adrenocorticotropin Membrane phosphoprotein binding sites in rat median The rate-determining step in cAMP-mediated exocytosis in the rat parotid eminence, 1271 and submandibular glands appears to involve analogous 26-kDa integral Mediterranean fever, familial membrane phosphoproteins, 3237 Circulating hydroxy fatty acids in familial Mediterranean fever, 1232 Membrane potential Medulla Incorporation of membrane potential into theoretical analysis of Serotonin neurons on the ventral brain surface, 7449 electrogenic ion pumps, 6869 Melouis Membrane protein Construction of telocentric chromosomes in Saccharomyces Phosphorylation of lens fiber cell membrane proteins, 653 cerevisiae, 2106 Anomalous interaction of the acetylcholine receptor protein with the Negative control for the initiation of meiosis in Schizosaccharomyces nonionic detergent Triton X-114, 958 pombe, 2447 Proteolytic modification of human complement protein C9: Loss of Repair-defect mutations inhibit rDNA magnification in Drosophila and poly(C9) and circular lesion formation without impairment of discriminate between meiotic and premeiotic magnification, 8095 function, 2128 A 38,000-dalton membrane protein (p38) present in synaptic Melotic recombination vesicles, 4137 High-frequency meiotic gene conversion between repeated genes on nonhomologous chromosomes in yeast, 3350 Membrane protein recycling Mechanism of insulin action on membrane protein recycling: A selective Melanin decrease in the phosphorylation state of insulin-like growth factor II Calcium binding in pigmented and albino eyes, 6716 receptors in the cell surface membrane, 7314 Molecular analysis of the yellow gene (y) region of Drosophila melanogaster, 7369 Membrane protein synthesis Homologies between the Salmonella typhimurium CheY protein and Melanoma proteins involved in the regulation of chemotaxis, membrane protein Strong antitumor activities of IgG3 antibodies to a human synthesis, and sporulation, 7989 melanoma-associated ganglioside, 1499 Disialoganglioside GD3 on human melanoma serves as a relevant target Membrane, purple antigen for monoclonal antibody-mediated tumor cytolysis, 5155 A neutron diffraction study on the location of the polyene chain of retinal in bacteriorhodopsin, 3227 Melanoma cell Evidence that a 90-kDa phosphoprotein, an associated kinase, and a Membrane receptor specific phosphatase are involved in the regulation of Cloudman Direct cross-Linking of i25I-labeled glucagon to its membrane receptor by melanoma cell proliferation by insulin, 1007 UV irradiation, 325 Ectopic peptides released by a human melanoma cell line that modulate the transformed phenotype, 5015 Membrane recnstituton Electron microscopic observation of domain movement in reconstituted Melanoma, t erythrocyte membranes, 7304 Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: A phase I trial in patients with malignant melanoma, 1242 Membrane synthesis Loss of polymorphic restriction fragments in malignant melanoma: Tunicamycin blocks the incorporation of opsin into retinal rod outer Implications for tumor heterogeneity, 1470 segment membranes, 1116 In vitro studies of 2,4-dihydroxyphenylaianine, a prodrug targeted against malignant melanoma cells, 2960 Membrane traffic In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against Tangier disease: A disorder of intracellular membrane traffic, 6305 malignant melanoma cells (Correction), 6020 Membrane transport system Membrane Anomalous properties of a simple small-volume membrane transport Fast and slow orientatiohal fluctuations in membranes, 2029 system at steady state, 3654 Direct measurement of lateral transport in membranes by using Membrane vesicle time-resolved spatial photometry, 4122 Acidic pH requirement for insertion of colicin El into artificial membrane vesicles: Relevance to the mechanism of action of colicins and certain Membrane-assocated enzyme toxins, 1386 Cloning, sequencing, and chromosomal localization of human term ATP is essential for protein translocation into Escherichia coil membrane placental alkaline phosphatase cDNA, 8715 vesicles, 4384 Membrane, blue Incorporation of beef heart cytochrome c oxidase as a proton-motive Importance of bound divalent cations to the tyrosine deprotonation force-generating mechanism in bacterial membrane vesicles, 7555 during the photocycle of bacteriorhodopsin, 3662 Memory Membrane channel Interaction of synaptic modification rules within populations of Acidic pH requirement for insertion of colicin El into artificial membrane neurons, 1291 vesicles: Relevance to the mechanism of action of colicins and certain The molecular electronic device and the biochip computer: Present toxins, 1386 status, 1874 Signal enhancement in distal cortical dendrites by means of interactions Membrane, excitable between active dendritic spines, 2192 Functional reconstitution of the purified brain sodium channel in planar Model of cortical organization embodying a basis for a theory of lipid bilayers, 240 information processing and memory recall, 2364 8902 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

A mechanism for memory storage insensitive to molecular turnover: A Methanol bistable autophosphorylating kinase, 3055 Role of hepatic tetrahydrofolate in the species difference in methanol Cholinergic ventral forebrain grafts into the neocortex improve passive toxicity, 3854 avoidance memory in a rat model of Alzheimer disease, 5227 Blockade of P- but not of P2-adrenergic receptors replicates Methionine propranolol's suppression of the cerebral spread of an engram in Stimulation of glycolysis and amino acid uptake in NRK-49F cells by mice, 7458 transforming growth factor P and epidermal growth factor, 1350 Monosynaptic connections made by the sensory neurons of the gill- and Methionine-sensitive glycolysis in transformed cells, 6750 siphon-withdrawal reflex in Aplysia participate in the storage of Met ynn bosynthsi long-term memory for sensitization, 8266 Regulation of methionine synthesis in Escherichia coli: Effect of metJ Meningococcus group B gene product and S-adenosylmethionine on the expression of the metF NZB mouse system for production of monoclonal antibodies to weak gene, 3601 bacterial antigens: Isolation of an IgG antibody to the polysaccharide Isolation and characterization of the product of the methionine-regulatory capsules of Escherichia coli K1 and group B meningococci, 1194 gene med of Escherichia coli K-12, 6104 Menstrual cycle Methiolne, initiator Cyclical secretion of prorenin during the menstrual cycle: Hb Long Island: A hemoglobin variant with a methionyl extension at the Synchronization with luteini7ing hormone and progesterone, 8705 NH2 terminus and aprolyl substitution for the normal histidyl residue 2 of the P chain, 4602 Merones ug das Amino-terminal processing of proteins: Hemoglobin South Florida, a Benzodiazepine/aminobutyric acid receptor deficit in the midbrain of variant with retention of initiator methionine and Na-acetylation, 8448 the seizure-susceptible gerbil, 6701 Methlext Merozoite Ultrastructural features of minute chromosomes in a Expression of Plasmodium falciparum surface antigens in Escherichia methotrexate-resistant mouse 3T3 cell line, 1126 coli, 2518 'y-Fluoromethotrexate: Synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to Mesenchymal cell, palatal form poly--lutamates, 2598 In vitro screening assay for teratogens using growth inhibition of human Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase embryonic cells, 5791 by methotrexate and dihydrofolic acid polyglutamates, 4881 Mesoscale system Metioxamine Nonlinear natural engine: Model for thermodynamic processes in Focal smooth muscle proliferation in the aortic intima produced by an mesoscale systems, 7805 initiation-promotion sequence, 3450 Mesothelial cell Methoilde Asbestos-associated chromosomal changes in human mesothelial Stabilization of higher-valent states of iron porphyrin by hydroxide and cells, 3884 methoxide ligands: Electrochemical generation of iron(IV)-oxo Messenpr ribonucleoprotein porphyrins, 4301 Hybrid selection of messenger ribonucleoprotein for serum albumin: Methyl-acceptlng chenmotaxis protein Analysis of specific message-bound proteins, 7327 Chimeric chemosensory transducers of Escherichia coli, 1326 Messeiger RNA Chimeric chemosensory transducers of Escherichia coli See mRNA (Correction), 6019 met gene Methyl IOde Regulation of methionine synthesis in Escherichia coli: Effect of metd Driving force and nucleophilicity in SN2 displacements, 8288 gene product and S-adenosylmethionine on the expression of the metF N-Methyl-N'-ntro-N-tro n gene, 3601 Quantitative assessment of the role of O6-methylguanine in the initiation Isolation and characterization of the product of the methionine-regulatory of carcinogenesis by methylating agents, 421 gene metJ of Escherichia coli K-12, 6104 N-Methyl-N-altresoures Metabolism Efficient induction and selection of chloroplast-encoded In vivo solvent-suppressed localized hydrogen nuclear magnetic antibiotic-resistant mutants in Nicotiana, 1485 resonance spectroscopy: A window to metabolism?, 2148 Lois of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen, 7810 Metabolite flux Midgestational abnormalities associated with in vitro preim'lantation Characterization of rate-controlling steps in vivo by use of an adjustable N-methyl-N-nitrosourea exposure with subsequent transfer to surrogate expression vector, 3577 mothers, 8757 Metal Hardness, softness, and the fukui function in the electronic theory of N-Methyl4-pheny-1,2,3,6-tetrahydrope metals and catalysis, 6723 Parkinsonism-inducing neurotoxin, N-methy-4-phenyl-1,2,3,6- Extension of the statistical theory of resonating valence bonds to tetrahydropyridine: Uptake of the metabolite N-methyl4- hyperelectronic metals, 8284 phenylpyndine by dopamine neurons explains selective toxicity, 2173 Comparison of the theoretical and experimental values of the number of N-Methyl-4jbenylpyre metallic orbitals per atom in hypoelectronic and hyperelectronic Parkinsonism-lnduciagtneurotoxin, N-methyl-4-phenyl-1,2,3,6- metals, 8286 tetrahydropyridine: Uptake of the metabolite N-methyl4- Metalloprotein phenylpyridine by dopamine neurons explains selective toxicity, 2173 Electrostatic influence on energetics of electron transfer reactions, 3082 Methylamlne Metallthionein Lysosomotropic agents selectively potentiate thrombin-induced acid Sea urchin metallothionein sequence: Key to an evolutionary hydrolase secretion from platelets, 2374 diversity, 4992 Methylamnobutyrate Stimulation of glycolysis and amino acid uptake in NRK-49F cells by Metallothionein gene transforming growth factor P and epidermal growth factor, 1350 Upstream promoter element of the human metallothionein-IIA gene can Glycolysis and methylaminoisobutyrate uptake in rat-i cells transfected act like an enhancer element, 8572 with ras or myc oncogenes, 3535 Metastasis Methylatlon Expression of the metastatic phenotype in cells transfected with human Sequential changes in DNA methylation patterns of the rat metastatic tumor DNA, 1726 phosphoenolpyruvate carboxykinase gene during development, 267 Tumorigenic and metastatic properties of "normal" and ras-transfected Phosphatidylcholine produced in rat synaptosomes by N-methylation is NIH/3T3 cells, 3698 enriched in polyunsaturated fatty acids, 4828 The hemodynamic destruction of intravascular cancer cells in relation to Stoichiometric methylation of calcineurin by protein carboxyl myocardial metastasis, 5737 O-methyltransferase and its effects on calmodulin-stimulated Metazoan phosphatase activity, 5612 Pellet microfossils: Possible evidence for metazoan life in Early Compensatory mutations in receptor function: A reevaluation of the role Proterozoic time, 5809 of methylation in bacterial chemotaxis, 8364 Methanpcoccus 3-Methylcholanthrene Structure and sequence divergence of two archaebacterial genes, 4207 Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: Differential expression of c-myc and Methanococcus vanniei c-myb, 565 Stereochemical studies of a selenium-containing hydrogenase from Methanococcus vannielii: Determination of the absolute configuration S-Methylctosine of C-5 chirally labeled dihydro-8-hydroxy-5-deazaflavin cofactor, 1364 Ethylation of poly(dC-dG)-poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in Methanococcu.s vola vitro, 1045 Electron transfer-driven ATP synthesis in Methanococcus voltae is not One role for DNA methylation in vertebrate cells is strand discrimination dependent on a proton electrochemical gradient, 6793 in mismatch repair, 7350 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8903

5,10-Methylenetetrahydrofolate reductase Microtubule Regulation of methionine synthesis in Escherichia coli: Effect of metd Immunophotoelectron microscopy: The electron optical analog of gene product and S-adenosylmethionine on the expression of the metF immunofluorescence microscopy, 109 gene, 3601 Phase-change kinetics for a microtubule with two free ends, 431 Monte Carlo study on the GTP cap in a five-start helix model of a O'-Methylguanine microtubule, 1131 Quantitative assessment of the role of 06-methylguanine in the initiation Microtubule-associhted proteins (MAPs): A monoclonal antibody to MAP of carcinogenesis by methylating agents, 421 1 decorates mierotubules in vitro but stains stress fibers and not Active site and complete sequence of the suicidal methyltransferase that microtubules in vivo, 1434 counters alkylation mutagenesis, 2688 Immunophotoelectron microscopy: The electron optical analog of 06-Alkylguanine-DNA alkyltransferase activity correlates with the immunofluorescence microscopy (Correction), 3062 therapeutic response of human rhabdomyosarcoma xenografts to Separation of endogenous calmodulin- and cAMP-dependent kinases from 142-chloroethyl)-3-trans-4-methylcyclohexyl)-1-nitrosourea, 2985 microtubule preparations, 3202 Possible depletion of a DNA repair enzyme in human lymphoma cells by Directed elongation modeLfor microtubule GTP hydrolysis, 3267 subversive repair, 5285 Theoretical treatment of microtubules disappearing in solution, 4127 uvrA and recA mutations inhibit a site-specific transition produced by a Microtubule configurations during fertilization, mitosis, and early single 06-methylguanine in gene G of bacteriophage OX174, 7173 development in the mouse and the requirement for egg microtubule-mediated motility during mammalian fertilization, 4152 7-Methylguanosine 5'-trlphosphate Analyzing the components of microtubules: Antibodies against chartins, Isolation and characterization of factors from wheat germ that exhibit associated proteins from cultured cells, 6581 eukaryotic initiation factor 4B activity and overcome Microtubule distribution in cultured cells and intact tissues: Improved 7-methylguanosine 5'-triphosphate inhibition of polypeptide immunolabeling resolution through the use of reversible embedment synthesis, 330 cytochemistry, 6889 Directed elongation model for microtubule GTP hydrolysis N-Methylpyrrolecarboxamide (Correction), 7474 Sequence-specific recognition of B-DNA by oligo(N-methyl Dansylated estramustine, a fluorescent probe for studies of estramustine pyrrolecarboxamide)s, 2565 uptake and identification of intracellular targets, 8483 Methyltransferase Microtubule-associated protein Active site and complete sequence of the suicidal methyltransferase that A widely distributed nuclear protein immunologically related to the counters alkylation mutagenesis, 2688 microtubule-associated protein MAP1 is associated with the mitotic Possible depletion of a DNA repair enzyme in human lymphoma cells by spindle, 1146 subversive repair, 5285 Microtubule-associated proteins (MAPs): A monoclonal antibody to MAP 1 decorates microtubules in vitro but stains stress fibers and not Mevalonate microtubules in vivo,. 1434 Defective macromolecule biosynthesis and cell-cycle progression in a Separation of endogenous calmodulin- and cAMP-dependent kinases from mammalian cell starved for mevalonate, 3257 microtubule preparations, 3202 Mevinolin Microtubule-associated protein 1B: Identification of a major component The influence of mevinolin on the adrenal cortical response to of the neuronal cytoskeleton, 5404 corticotropin in heterozygous familial hypercholesterolemia, 6291 Mr 205,000 sulfoglycoprotein in extracellular matrix of mouse fibroblast cells is immunologically related to high moecular weight Microcapsule microtubule-associated proteins, 5776 Radioimmunoassay for 6-D-tryptophan analog of luteinizing Differential expression of distinct microtubule-associated proteins during hormone-releasing hormone: Measurement of serum levels after brain development, 6006 administration of long-acting microcapsule formulations, 1547 Combination of long-acting microcapsules of the D-tryptophan-6 analog of Milk protein luteinizing hormone-releasing hormone with chemotherapy: Interaction of mouse mammary epithelial cells with collagen substrata: Investigation in the rat prostate cancer model, 2498 Regulation of casein gene expression and secretion, 1419 Milrinone MNicodissection Milrinone and thyroid hormone stimulate myocardial membrane Microdissection and microcloning of the mouse X chromosome, 5846 Ca2+-ATPase activity and share structural homologies, 7974 Microfflament Calmodulin accelerates the rate of polymerization of human platelet actin Mini-Mu and alters the structural characteristics of actin filaments, 1683 DNA sequences at the ends of the genome of bacteriophage Mu essential 3-Deazaadenosine-induced disorganization of macrophage for transposition, 2087 microfilaments, 4060 Miniature endplate potential Is an acetylcholine transport system responsible for nonquantal release of Microflora, intestinal acetylcholine at the rodent myoneural junction?, 3514 Catabolism of premercapturic acid pathway metabolites of naphthalene to naphthols and methylthio-containing metabolites in rats, 668 Mink cell focus-forming virus Friend and Moloney murine leukemia viruses specifically recombine with Mlcrofossil different endogenous retroviral sequences to generate mink cell Pellet microfossils: Possible evidence for metazoan life in Early focus-forming viruses, 459 Proterozoic time, 5809 Minute virus of mice A-Microglobulin Mouse DNA polymerase a-primase terminates and reinitiates DNA Human major histocompatibility complex class I antigens: Residues synthesis 2-14 nucleotides upstream of C2A12(C23/T2) sequences on a 61-83 of the HLA-B7 heavy chain specify an alloreactive site, 539 minute virus of mice DNA template, 4023 Molecular analysis of an EL4 cell line that expresses H-2Db but not H-2Kb or j32-microglobulin, 2950 Msmatch repair Three-dimensional structure of P2-microglobulin, 4225 Repair of defined single base-pair mismatches in Escherichia coli, 503 P2-Microglobulin gene Mitochondria Retroviral insertional mutagenesis of a target allele in a heterozygous Nucleotide sequence of Fo-ATPase proteolipid (subunit 9) gene of maize murine cell line, 6600 mitochondria, 1015 Purified hydrophobic proteins, chargerins, are essential for energy Microinjection, fusion-mediated transduction in oxidative phosphorylation, 1331 Targeting of loaded Sendai virus envelopes by covalently attached insulin Ochromonas mitochondria contain a specific chloroplast protein, 1456 molecules to virus receptor-depleted cells: Fusion-mediated Mechanism of inhibition of mitochondrial adenosine triphosphatase by microinjection of ricin A and simian virus 40 DNA, 7309 dicyclohexylcarbodiimide and oligomycin: Relationship to ATP synthesis, 1589 Micronucleus Characterization of a yeast mitochondrial promoter by deletion Deposition-related histone acetylation in micronucleus of conjugating mutagenesis, 1954 Tetrahymena, 8048 Developmental expression of nuclear genes that encode mitochondrial proteins: Insect cytochromes c, 1964 Mcroscopy Two nonidentical forms of subunit V are functional in yeast cytochrome Immunophotoelectron microscopy: The electron optical analog of c oxidase, 2235 immunofluorescence microscopy, 109 Pattern analysis of 5S rRNA, 2437 Imaging of optically active biological structures by use of circularly Mitochondrial modulation of maternally transmitted antigen: Analysis of polarized light, 401 cell hybrids, 3286 Immunophotoelectron microscopy: The electron optical analog of Genes for respiratory chain proteins and ribosomal RNAs are present on immunofluorescence microscopy (Correction), 3062 a 16-kilobase-pair DNA species from Chlamydomonas reinhardtii mitochondria, 3340 Microsome Mitochondrial origins, 4443 Genetic differences in oxygen toxicity are-correlated with cytochrome Origin and turnover of mitochondrial glutathione, 4668 P-450 inducibility, 6315 Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor, 4930 Microsporidian Molecular cloning and amino acid sequence of the precursor form of Experimental transmission of a microsporidian pathogen from mosquitoes bovine adrenodoxin: Evidence for a previously unidentified to an alternate copepod host, 5574 COOH-terminal peptide, 5705 8904 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Cloning and sequence analysis of a cDNA encoding porcine Strong antitumor activities of IgG3 antibodies to a human mitochondrial aspartate aminotransferase precursor, 6065 melanoma-associated ganglioside, 1499 Maize mitochondria synthesize organ-specific polypeptides, 6879 Role of the Bp3S cell surface polypeptide in human B-cell activation, 1766 Mitochondrial DNA Identification of a surface antigen on Theileria parva sporozoites by Priming of human mitochondrial DNA replication occurs at the monoclonal antibody, 1771 light-strand promoter, 351 From monoclonal antibody to gene for a neuron-specific glycoprotein in Differential expression of mitochondrial genes between life cycle stages Drosophila, 1855 of Trypanosoma brucei, 3380 Evidence for unpredicted transmembrane domains in acetylcholine receptor subunits, 2004 Mitochondrial uncoupling protein Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently Molecular approach to thermogenesis in brown adipose tissue: ctDNA antigens for IgM paraproteins, 6697 cloning of the mitochondrial uncoupling protein, 445 Monoclonal antibody that defines human myoepithelium, 7409 Mitogenesis Monoclonal antibodies to human vitamin D-binding protein, 8429 The product of the protooncogene c-sri is modified during the cellular Monoclonal antibody, anti-idlotypic response to platelet-derived growth factor, 7845 P-Adrenergic agonist activity of a monoclonal anti-idiotypic Stabilized complexes of epidermal growth factor and its receptor on the 1781 cell surface stimulate RNA synthesis but not mitogenesis, 8513 antibody, Mltosls Monoclonal antibody, antiplatelet Intracellular free calcium levels are reduced in mitotic Pt K2 epithelial Thrombus radioimmunoscintigraphy: An approach using monoclonal cells, 800 antiplatelet antibody, 3465 Construction of telocentric chromosomes in Saccharomyces Monoclonal antibody cytotoxicity cerevisiae, 2106 Isolation and characterization of apti-monosialoganglioside monoclonal Fluctuation of the Ca2+-sequestering activity of permeabilized sea urchin antibody 19-9 class-switch variants, 8653 embryos during the cell cycle, 2389 Microtubule configurations during fertilization, mitosis, and early Monoonal antibody, human development in the mouse and the requirement for egg Protection against Gram-negative bacteremia and endotoxemia with microtubule-mediated motility during mammalian fertilization, 4152 human monoclonal IgM antibodies, 1790 Caenorhabditis elegans DNA that directs segregation in yeast cells, 4167 Monoclonal antibody inmunoblot Mitotic spindle Characterization of monoclonal antibodies against Chlamydomonas A widely distributed nuclear protein immunologically related to the flageilar dyneins by high-resolution protein blotting, 4717 microtubule-associated protein MAP1 is associated with the mitotic spindle, 1146 Monoclonal antibody immunotoxin A monoclonal immunotoxin acting on the Na+ channel, with properties Mixed lymphocyte reacton similar to those of a scorpion toxin, 1842 Involvement of I-J epitopes in the self- and allo-recognition sites of T cells: Blocking of syngeneic and allogeneic mixed lymphocyte Monoclonal antibody, monkey reaction-responder cells by monoclonal anti-I-J antibodies, 2905 Monkey-derived monoclonal antibodies against Plasmodium Properties of memory T lymphocytes isolated from the mixed leukocyte falciparum, 6272 reaction, 7686 Monoclonal antibody NCD-1 Mln-2 gene A monoclonal antibody disrupting calcium-dependent cell-cell adhesion Insertion of long interspersed repeated elements at the Igh of brain tissues: Possible role of its target antigen in animal pattern (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus formation, 2789 integration 2) loci of rats, 2857 Monoclonal antibody, neutrlng Molecular assembly Selection of unique antigemic variants of Newcastle disease virus with Supramolecular assemblies of mRNA direct the coordinated synthesis of neutralizing monoclonal antibodies and anti-immunoglobulin, 7106 type I procollagen chains, 3693 Monoclonal antibody, renal cancer Molecular dock Specificity analysis of mouse monoclonal antibodies defining cell surface Superoxide dismutase: An evolutionary puzzle, 824 antigens of human renal cancer, 2955 Evidence for higher rates of nucleotide substitution in rodents than in Specificity analysis of mouse monoclonal antibodies defining cell surface man, 1741 antigens of human renal cancer (Correction), 5236 Molecular drive Monoclonal antibody TH-1 Interaction of selection and biased gene conversion in a multigene Repetitive A epitope (type 3 chain A) defined by blood group Al-specific family, 153 monoclonal antibody TH-1: Chemical basis of qualitative A1 and A2 distinction, 1199 Molecular dynamics simulation Repetitive A epitope (type 3 chain A) defined by blood group Al-specific Molecular dynamics simulations of d(C-G-C-G-A)-d(T-C-G-C-G) with and monoclonal antibody TH-1: Chemical basis of qualitative A1 and A2 without "hydrated" counterions, 755 distinction (Correction), 3948 Molecular dynamics simulation of photodissociation of carbon monoxide from hemoglobin, 2034 Monoclonal antibody therapy A molecular dynamics simulation of double-helical B-DNA including In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat counterions and water, 6537 by antibody to class II major histocompatibility complex gene products, 6627 Molecular electronic device The molecular electronic device and the biochip computer: Present Monoclonal antibody to hormone status, 1874 Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing'hormone: Reacting determinant and action on Molecular orbital ovulation and estrus suppression, 1228 Topology of bonding in ir-electron systems, 1 Monocyte Molybdkte Expression of the a1-proteinase inhibitor gene in human monocytes and Molybdate reduction by Escherichia coli K-12 and its chl mutants, 227 macrophages, 795 Molybdate reduction by Escherichia coli K-12 and its chl mutants Regulation of cellular function by products of lysosomal enzyme activity: (Correction), 3532 Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or Monkey polymorphonuclear leukocytes, 2468 Transcription factor Spl recognizes promoter sequences from the Differentiation-enhanced binding of the amino-terminal fragment of monkey genome that are similar to the simian virus 40 promoter, 4915 human urokinase plasminogen activator to a specific receptor on U937 monocytes, 4939 Monoamine oxidase Differentiation of a human leukemia cell line and expression of N-Nitrosodialkylamines do not function as substrates for liver collagenase inhibitor, 5380 monoamine oxidase, 682 Monoclonal antibodies against human Ia antigens stimulate monocytes to Monoclonal antibody secrete interleukin 1, 6652 Murine monoclonal antibodies to the myelin-associated glycoprotein react Human monocyte-endothelial cell interaction in vitro, 8208 with large granular lymphocytes of human blood, 552 Administration of recombinant interferon y to cancer patients enhances NZB mouse system for production of monoclonal antibodies to weak monocyte secretion of hydrogen peroxide, 8686 bacterial antigens: Isolation of an IgG antibody to the polysaccharide Monode4ihs domest/ca capsules of Escherichia coli K1 and group B meningococci, 1194 Photoreactivation of UV-induced pyrimidine dimers and erythema in the Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: A phase I 2409 trial in patients with malignant melanoma, 1242 marsupial Monodelphis domestica, Precise localization of genes on large animal virus genomes: Use of Xgtll Monooxygenase and monoclonal antibodies to map the gene for a cytomegalovirus Isolation and sequence of a human cytochrome P450 cDNA clone, 983 protein family, 1266 Microtubule-associated proteins (MAPs): A monoclonal antibody to MAP Monte Carlo study 1 decorates microtubules in vitro but stains stress fibers and not Monte Carlo study on the GTP cap in a five-start helix model of a microtubules in vivo, 1434 microtubule, 1131 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8905

Morphine Cloning and characterization of cDNAs encoding 2,3,7,8-tetra- Isolation of morphine from toad skin, 1852 chlorodibenzo- dioxin-inducible rabbit mRNAs for cytochrome P-450 Morphine and other opiates from beef brain and adrenal, 5203 isozymes 4 and 6, 5310 Visualization of 1l opiate receptors in rat brain by using a computerized c-myc mRNA levels in the cell cycle change in mouse erythroleukemia autoradiographic subtraction technique, 6667 cells following inducer treatment, 5323 Isolation, sequencing, synthesis, and pharmacological characterization of Hybrid selection of messenger ribonucleoprotein for serum albumin: two brain neuropeptides that modulate the action of morphine, 7757 Analysis of specific message-bound proteins, 7327 Morphogenesis mRNA abundance See also Development and Differentiation Developmental and hormonal regulation of a2u-globulin gene A monoclonal antibody disrupting calcium-dependent cell-cell adhesion transcription, 2579 of brain tissues: Possible role of its target antigen in animal pattern formation, 2789 mRNA accumulation Morphogenetic rearrangement of injected collagen in developing chicken Activity regulates the levels of acetylcholine receptor a-subunit mRNA in cultured chicken myotubes, 4558 limb buds, 2804 Accumulation of hydroxyproline-rich glycoprotein mRNAs in response to nos gene fungal elicitor and infection, 6551 Genomic structure of the cottontail rabbit (Shope) papillomavirus, 1580 Synthesis of pathogenesis-related proteins in tobacco is regulated at the Epidermal growth factor precursor is related to the translation product of level of mRNA accumulation and occurs on membrane-bound the Moloney sarcoma virus oncogene mos, 1921 polysomes, 7999 Mosquito mRNA, apolipoprotein B Experimental transmission of a microsporidian pathogen from mosquitoes Cloning and expression of apolipoprotein B, the major protein of low and to an alternate copepod host, 5574 very low density lipoproteins, 4597 Enhanced mosquito blood-finding success on parasitemic hosts: Evidence A partial cDNA clone for human apoliprotein B, 4983 for vector-parasite mutualism, 7725 mRNA, apolipoprotein E Mother Apolipoprotem E mRNA is abundant in the brain and adrenals, as well How infant and mother jointly contribute to developing cognitive as in the liver, and is present in other peripheral tissues of rats and competence in the child, 7470 marmosets, 203 Motility, gliding mRNA, biclstronk "Frizzy" genes of Myxococcus xanthus are involved in control of Reovirus hemagglutinin mRNA codes for two polypeptides in overlapping frequency of reversal of gliding motility, 8767 reading frames, 48 MT3antiven mRNA cap Molecular characterization of MT3 antigens by two-dimensional gel Isolation and characterization of factors from wheat germ that exhibit electrophoresis, NH2-terminal amino acid sequence analysis, and eukaryotic initiation factor 4B activity and overcome Southern blot analysis, 3794 7-methylguanosine 5'-triphosphate inhibition of polypeptide synthesis, 330 Mouse Cap-dependent RNA splicing in a HeLa nuclear extract, 7590 Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues, 1451 mRNA, chrolon protein Synthetic pheromones that promote inter-male aggression in mice, 2059 Nucleotide sequence of an unusual regionally expressed silkmoth chorion Cloning and sequencing of cDNA encoding the complete mouse liver RNA: Predicted primary and secondary structures of an architectural alcohol dehydrogenase, 2262 protein, 6035 Evolution of mouse major histocompatibility complex genes borne by t chromosomes, 2819 mRNA dedon Toward an analogue of alcoholism in mice: Criteria for recognition of Increased rate of degradation of c-myc mRNA in interferon-treated Daudi pharmacologically motivated drinking, 3469 cells, 4896 Mouse erythroleukemia cell mRNA, developmentally regulated Adult and fetal human globin genes are expressed following chromosomal A developmentally regulated mRNA from 3T3 adipocytes encodes a transfer into MEL cells, 780 novel serine protease homologue, 6480 Mouse mammary tumor virus mRNA, enkephain Hormonal response region in the mouse mammary tumor virus long Electroconvulsive shock increases preproenkephalin messenger RNA terminal repeat can be dissociated from the proviral promoter and has abundance in rat hypothalamus, 589 enhancer properties, 1020 Expression of preproenkephalin-like mRNA and its peptide products in Characterization of a protein, released by the T47D cell line, mammalian testis and ovary, 7467 immunologically related to the major envelope protein of mouse Depolarization regulates adrenal preproenkephalin mRNA, 8252 mammary tumor virus, 1531 mRNA, enolase Glucocorticoid regulation of mouse mammary tumor virus sequences in Molecular cloning and the nucleotide sequence of cDNA for transgenic mice, 5880 neuron-specific enolase messenger RNA of rat brain, 7453 Mouse, neurological mutant mRNA formation Transmissible spongiform encephalopathy in the gray tremor mutant Calmodulin genes in trypanosomes are tandemly repeated and produce mouse, 253 multiple mRNAs with a common 5' leader sequence, 3998 Mouse, New Zealand mRNA, histone Cortical anomalies in brains of New Zealand mice: A neuropathologic A unique subspecies of histone H4 mRNA from rat myoblasts contains model of dyslexia?, 8072 poly(A), 6760 Mouse, nonobese diabetic mRNA induction Prevention of type I diabetes in nonobese diabetic mice by allogeneic Nerve growth factor rapidly induces ornithne decarboxylase mRNA in bone marrow transplantation, 7743 PC12 rat pheochromocytoma cells, 5761 Rapid transient induction of phenylalanine ammonia-lyase mRNA in Mouse, RhI elicitor-treated bean cells, 6731 Effect of dietary ascorbic acid on the incidence of spontaneous mammary Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction tumors in RIII mice, 5185 during development and in response to glucocorticoids and Mouse, tr ic insulin, 8242 Factors affecting the efficiency of introducing foreign DNA into mice by mRNA injection microinjecting eggs, 4438 6586 Efficient insertion of genes into the mouse germ line via retrovial Growing Xenopus oocytes have spare translational capacity, vectors, 6148 mRNA, maternal Insertion of a bacterial gene into the mouse germ line using an infectious Mobilization of specific maternal RNA species into polysomes after retrovirus vector, 8587 fertilization in Xenopus laevis, 7636 mRNA mRNA, olfactory marker protein See also RNA Olfactory neuron-specific protein is translated from a large poly(A)+ Multiple polymorphic a- and P-tubulin mRNAs are present in sea urchin mRNA, 5218 eggs, 134 Nucleotide sequence of murine ornithine decarboxylase mRNA, 1673 Differential efficiencies of in vitro translation of mouse c-myc transcripts Papillomavirus genomes in human cervical tumors: Analysis of their differing in the 5' untranslated region, 2315 transcriptional activity, 5540 A lethal deletion on mouse chromosome 7 affects regulation of liver-cell-specific functions: Posttranscriptional control of serum mRNA, poy(A)+ protein and transcriptional control of aldolase B synthesis, 2442 Choline acetyltransferase and acetylcholine in Xenopus oocytes injected Structure of human ferritin light subunit messenger RNA: Comparison with mRNA from the electric lobe of Torpedo, 608 with heavy subunit message and functional implications, 3139 Structure of a human histone cDNA: Evidence that basally expressed Supramolecular assemblies of mRNA direct the coordinated synthesis of histone genes have intervening sequences and encode polyadenylylated type I procollagen chains, 3693 mRNAs, 2834 8906 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) mRNA, polycistronic Apolipoprotein multigene family: Tandem organization of human Analysis of the transcript encoding the latent Epstein-Barr virus nuclear apolipoprotein AI, CIII, and AIV genes, 6374 antigen I: A potentially polycistronic message generated by long-range Sequence directed mutagenesis: Evidence from a phylogenetic history of splicing of several exons, 8305 human a-interferon genes, 8577 mRNA processing Multiple sclerosis Gene encoding human growth hormone-releasing factor precursor: Selective loss of a subset of T helper cells in active multiple Structure, sequence, and chromosomal assignment, 63 sclerosis, 7389 Polyadenylylation of sea urchin histone RNA sequences in transfected COS cells, 1094 2-smn plasmid A sequence downstream of A-A-U-A-A-A is required for formation of Two-micrometer circle site-specific recombination: The minimal substrate simian virus 40 late mRNA 3' termini in frog oocytes, 3949 and the possible role of flanking sequences, 5875 Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in The FLP recombinase of the yeast 2-pm plasmid: Characterization of its vivo, 4346 recombination site, 7270 mRNA, proliferin Map gene Identification of proliferin mRNA and protein in mouse placenta, 4356 Evolutionary amplification of a pseudogene, 4182 mRNA reglation Murein synthesis The CaW+-binding protein parvalbumin: Molecular cloning and Penicillin binding proteins: Role in initiation of murein synthesis in developmental regulation of mRNA abundance, 1414 Escherichia coli, 5632 Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation, 4221 Murine leukemia virus Regulation of vitamin D metabolites of ribonucleic acid Friend and Moloney murine leukemia viruses specifically recombine with messenger for different endogenous retroviral sequences to generate mink cell preproparathyroid hormone in isolated bovine parathyroid cells, 4270 focus-forming viruses, 459 mRNA screening Murine leukemia virus protease is encoded by the gag-pol gene and is Identification of cDNA clones encoding a precursor of rat liver cathepsin synthesized through suppression of an amber termination codon, 1618 B, 2320 Retroviral insertional mutagenesis of a target allele in a heterozygous murine cell line, 6600 mRNA spicing Correlation of cell-surface phenotype with the establishment of Developmental variations in the splicing pattern of transcripts from the interleukin 3-dependent cell lines from wild-mouse murine leukemia Drosophila gene encoding myosin alkali light chain result in different virus-induced neoplasms, 6687 carboxyl-terminal amino acid sequences, 449 Retrovirus-induced spongiform encephalopathy: The 3'-end long terminal mRNA precursor splicing in vivo: Sequence requirements determined by repeat-containing viral sequences influence the incidence of the disease deletion analysis of an intervening sequence, 2885 and the specificity of the neurological syndrome, 8818 Alternative splicing patterns in an aberrantly rearranged immunoglobulin K-light-chain gene, 4045 Murine leukemia virus, Abelson Isolation and characterization of two fractions from HeLa cells required Friend murine leukemia virus-immortalized myeloid cells are converted for mRNA splicing in vitro, 4351 into tumorigenic cell lines by Abelson leukemia virus, 3306 A muscle-type tropomyosin in human fibroblasts: Evidence for expression by an alternative RNA 7835 Murine leukemia virus, Friend splicing mechanism, Friend murine leukemia virus-immortalized myeloid cells are converted mRNA stabilization into tumorigenic cell lines by Abelson leukemia virus, 3306 mRNA stabilization controls the expression of a class of developmentally Induction of the early stages of Friend erythroleukemia with helper-free regulated genes in Dictyostelium discoideum, 5786 Friend spleen focus-forming virus, 6913 mRNA translation Murine leukemia virus, Moloney Injected anti-sense RNAs specifically block messenger RNA translation Replication-competent Moloney murine leukemia virus carrying a in vivo, 144 bacterial suppressor tRNA gene: Selective cloning of proviral and Identification of the components necessary for adenovirus translational flanking host sequences, 1141 control and their utilization in cDNA expression vectors, 689 Isolation of embryonal carcinoma cell lines that express integrated Heat shock increases the synthesis of the poly(A)-binding protein in recombinant genes flanked by the Moloney murine leukemia virus long HeLa cells, 6884 terminal repeat, 2422 mRNA, tubulin Murine mammary tumor virus Insulin, insulin-like growth factor II, and nerve growth factor effects on Estradiol 16a-hydroxylation in the mouse correlates with mammary tubulin mRNA levels and neurite formation, 7126 tumor incidence and presence of murine mammary tumor virus: A possible model for the hormonal etiology of breast cancer in mRNA, tyrodne hydroxylase humans, 6295 Complete coding sequence of rat tyrosine hydroxylase mRNA, 617 Murine sarcoma virus, Moloney mRNA, vasopressin Epidermal growth factor precursor is related to the translation product of Vasopressin mRNA in situ hybridization: Localization and regulation the Moloney sarcoma virus oncogene mos, 1921 studied with oligonucleotide cDNA probes in normal and Brattleboro Rates of evolution of the retroviral oncogene of Moloney murine sarcoma rat hypothalamus, 5555 virus and of its cellular homologues, 4198 mac gene Musca domesica Genes from plasmid pKM101 in Haemophilus influenzae: Separation of Light-activated guanosinetriphosphatase in Musca eye membranes functions of mucA and mucB, 7753 resembles the prolonged depolarizing afterpotential in photoreceptor mucAB operon cells, 7116 umuDC and mucAB operons whose products are required for UV light- Muscarinic receptor and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins Different effects of N-ethylmalemide on Ml and M2 muscarine receptors share homology, 4331 in rat brain, 580 Muscarinic cholinergic receptor in the human heart evidenced under MUiler glia cell physiological conditions by positron emission tomography, 584 Antiserum to lens antigens immunostains Maller glia cells in the neural Two types of muscarinic response to acetylcholine in mammalian cortical retina, 5570 neurons, 6344 Multigene family Muscle Interaction of selection and biased gene conversion in a multigene All components required for the eventual activation of muscle-specific family, 153 actin genes are localized in the subequatorial region of an uncleaved Variances and covariances of identity coefficients of a multigene amphibian egg, 139 family, 829 Developmental variations in the splicing pattern of transcripts from the Nitrogenase reductase: A functional multigene family in Rhizobium Drosophila gene encoding myosin alkali light chain result in different phaseoli, 1170 carboxyl-terminal amino acid sequences, 449 Immunoglobulin VH gene structure and diversity in Heterodontus, a ADP dissociation from actomyosin subfiagment 1 is sufficiently slow to phylogenetically primitive shark, 2082 limit the unloaded shortening velocity in vertebrate muscle, 658 Evolution and organization of the fibrinogen locus on chromosome 4: Renaturation of skeletal muscle tropomyosin: Implications for in vivo Gene duplication accompanied by transposition and inversion, 2344 assembly, 2359 Antifreeze protein genes are tandemly linked and clustered in the genome 32-Adrenergic receptors contribute to catecholamine-stimulated of the winter flounder, 2613 shortening of action potential duration in dog atrial muscle, 4521 Silkmoth chorion gene families contain patchwork patterns of sequence Brain and muscle nicotinic acetylcholine receptors are different but homology, 2814 homologous proteins, 5208 Chromosomal assignments of the genes coding for human types II, III, Inositol 1,4,5-trisphosphate: A possible chemical link in and IV collagen: A dispersed gene family, 3330 excitation-contraction coupling in muscle, 6352 Human al(III) and a2(V) procollagen genes are located on the long arm The subsynaptic 43-kDa protein is concentrated at developing of chromosome 2, 3385 nerve-muscle synapses in vitro, 8270 Linkage and homology analysis divides the eight genes for the small subunit of petunia ribulose 1,5-bisphosphate carboxylase into three Muscle, cadic gene families, 4964 Genes for skeletal muscle myosin heavy chains are clustered and are not A 78-kilobase region of mouse chromosome 3 contains salivary and located on the same mouse chromosome as a cardiac myosin heavy pancreatic amylase genes and a pseudogene, 5446 chain gene, 7183 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8907

Complete nucleotide sequence of dog heart creatine kinase mRNA: Mutagenesis, chemical Conservation of amino acid sequence within and among species, 8394 umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins Muscle cell share homology, 4331 Use of a replica technique to isolate muscle cell lines defective in Dose-repetition increases the mutagenic effectiveness of expressing the acetylcholine receptor, 124 N-ethyl-N-nitrosourea in mouse spermatogonia, 6619 Muscle contraction Mutagenesis, deletion Structure of the actin-myosin complex in the presence of ATP, 3247 Characterization of a yeast mitochondrial promoter by deletion Increases in muscle Ca2+ mediate changes in acetylcholinesterase and mutagenesis, 1954 acetylcholine receptors caused by muscle contraction, 7121 Localization of Ca2+ release channels with ryanodine in junctional Mutagenesis, engineered terminal cisternae of sarcoplasmic reticulum of fast skeletal Altered Cro repressors from engineered mutagenesis of a synthetic cro muscle, 7256 gene, 1084 Fraction of myosin cross-bridges bound to actin in active muscle fibers: Mutagenesis is vitro Estimation by fluorescence anisotropy measurements, 8478 Active site of triosephosphate isomerase: In vitro mutagenesis and Muscle development characterization of an altered enzyme, 2272 The Ca2+-binding protein parvalbumin: Molecular cloning and Mutagenesis, Inducible developmental regulation of mRNA abundance, 1414 Structural analysis of the umu operon required for inducible mutagenesis Muscle, skeletal in Escherichia coli, 4336 The all-or-none role of innervation in expression of apamin receptor and Mutagenesis, insertional of apamin-sensitive Ca2+-activated K+ channel in mammalian skeletal Application of the mini-Mu-phage for target-sequence-specific insertional muscle, 2188 mutagenesis of the herpes simplex virus genome, 4773 Developmentally regulated expression of a chicken muscle-specific gene Retroviral insertional mutagenesis of a target allele in a heterozygous in stably transfected rat myogenic cells, 3106 murine cell line, 6600 Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase, 3187 Mutagnes, site-specific Purification and crystallization of the calcium binding protein of Rapid and efficient site-specific mutagenesis without phenotypic sarcoplasmic reticulum from skeletal muscle, 4036 selection, 488 Neural cell adhesion molecule (N-CAM) accumulates in denervated and Structure of proteins with single-site mutations: A minimum perturbation paralyzed skeletal muscles, 4544 approach, 1697 Developmentally regulated expression of a chicken muscle-specific gene Active site of triosephosphate isomerase: In vitro mutagenesis and in stably transfected rat myogenic cells (Correction), 5578 characterization of an altered enzyme, 2272 Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent Two-codon insertion mutagenesis of plasmid genes by using protein kinase from rabbit skeletal muscle, 5732 single-stranded hexamenc oligonucleotides, 4202 The Ca channel in skeletal muscle is a large pore, 7149 Site-specific mutagenesis of histidine residues in the lac permease of Genes for skeletal muscle myosin heavy chains are clustered and are not Escherichia coli, 6765 located on the same mouse chromosome as a cardiac myosin heavy Transition-state stabilization in the mechanism of tyrosyl-tRNA chain gene, 7183 synthetase revealed by protein engineering, 7840 Myogenic growth factor present in skeletal muscle is purified by Sequence directed mutagenesis: Evidence from a phylogenetic history of heparin-affinity chromatography, 8044 human a-interferon genes, 8577 Structure, evolution, and regulation of a fast skeletal muscle troponin I gene, 8080 Mutagne, SOS Control of oxidative metabolism and oxygen delivery in human skeletal Dual role for Escherichia coli RecA protein in SOS mutagenesis, 3325 muscle: A steady-state analysis of the work/energy cost transfer Mutagenesis, ultraviet radiatIon function, 8384 Mutagenic repair in Escherichia coli: Products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced Muscle, smooth mutagenesis, 4193 Phorbol ester effects on neurotransmission: Interaction with umuDC and mucAB Qperons whose products are required for UV light- neurotransmitters and calcium in smooth muscle, 604 and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins Incorporation of cellular and plasma fibronectins into smooth muscle cell share 4331 extracellular matrix in vitro, 2746 homology, Focal smooth muscle proliferation in the aortic intima produced by an Mutation initiation-promotion sequence, 3450 Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell Inositol trisphosphate-induced calcium release and contraction in line, 479 vascular smooth muscle, 5231 Cells from an immunodeficient patient (46BR) with a defect in DNA Activation of tracheal smooth muscle contraction: Synergism between ligation are hypomutable but hypersensitive to the induction of sister Ca2+ and activators of protein kinase C, 8835 chromatid exchanges, 2044 Evidence for linear response for the induction of mutations in human Muscular dystrophy cells by x-ray exposures below 10 rads, 2092 Biochemical rationale and the cardiac response of patients with muscle Generation of single base-pair deletions, insertions, and substitutions by disease to therapy with coenzyme Qio, 4513 a site-specific recombination system, 6990 Specific cloning of DNA fragments absent from the DNA of a male A method to detect and characterize point mutations in transcribed patient with an X chromosome deletion, 4778 genes: Amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells, 7575 Mustare Alkylating agent resistance: In vitro studies with human cell lines, 2158 Mutation, dominant Molecular genetics of a transposon-induced dominant mutation in the Mutagen, dietary Drosophila locus Glued, 1751 Metabolically activated steviol, the aglycone of stevioside, is mutagenic, 2478 Mutation, point Point mutation generates constitutive expression of an inducible Mutagenesis eukaryotic gene, 643 Repair of defined single base-pair mismatches in Escherichia coli, 503 Mutagenic DNA repair in Streptomyces, 1180 Mutation rate Lack of evidence for skeletal abnormalities in offspring of mice exposed Rapid change in mutation rate in a local population of Drosophila to ethylnitrosourea, 2852 melanogaster, 7671 Sequence context effects in DNA replication blocks induced by aflatoxin Mutation screening B1, 3096 Detection of neutral amino acid substitutions in proteins, 7646 Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: Evidence for a possible role in Mutation, sequential mutagenesis, 3182 Identification and order of sequential mutations in P-actin genes isolated Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase from increasingly tumorigenic human fibroblast strains, 6995 involves improved nucleotide selection, 3889 Differences in mutagenic and recombinational DNA repair in Mutation, silent enterobacteria, 4172 Rapid and efficient site-specific mutagenesis without phenotypic UV-induced mutagenesis of phage S13 can occur in the absence of the selection, 488 RecA and UmuC proteins of Escherichia coli, 6614 Mutagenesis of the lac promoter region in M13 mplO phage DNA by Mutation, somatic 4'-hydroxymethyl-4,5',8-trimethylpsoralen, 7355 Activation of an N-ras gene in acute myeloblastic leukemia through Modification of DNA by glucose 6-phosphate induces DNA somatic mutation in the first exon, 879 in an Nucleotide sequence preservation of human mitochondrial DNA, 2895 rearrangements Escherichia coli plasmid, 8439 A contact-insensitive subpopulation in Syrian hamster cell cultures with a The lacI shuttle: Rapid analysis of the mutagenic specificity of ultraviolet greater susceptibility to chemically induced neoplastic light in human cells, 8606 transformation, 5005 Low frequency of somatic mutation in a-chain variable region genes of Mutagenesis, base analogue human T-cell receptors, 7701 A fidelity assay using "dideoxy" DNA sequencing: A measurement of sequence dependence and frequency of forming 5-bromouracil-guanine Mutation, spontaneous base mispairs, 1301 Biological effects of background radiation: Mutagenicity of 'OK, 8602 8908 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Mutation, transition Developmentally regulated expression of a chicken muscle-specific gene DNA methylation at asymmetric sites is associated with numerous in stably transfected rat myogenic cells, 3106 transition mutations, 8114 Developmentally regulated expression of a chicken muscle-specific gene in stably transfected rat myogenic cells (Correction), 5578 Myasthenia gravis, experimental autoimmune Correlation between fusion and the developmental regulation of Region of peptide 125-147 of acetylcholine receptor a subunit is exposed membrane glycoproteins in L6 myoblasts, 8409 at neuromuscular junction and induces experimental autoimmune myasthenia gravis, T-cell immunity, and modulating Myogenic cell autoantibodies, 8805 Ascorbic acid mediates acetylcholine receptor increase induced by brain extract of myogenic cells, 575 Myasthenic serum Myasthenic serum selectively blocks acetylcholine receptors with long Myogenic growth factor channel open times at developing rat endplates, 2533 Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography, 8044 myc gene A retrovirual myc gene induces preneoplastic transformation of Myoglobin lymphocytes in a bursal transplantation assay, 222 Protein states and proteinquakes, 5000 Distinctive effects of the viral oncogenes myc, erb, fps, and src on the Cloning, expression in Escherichia coli, and reconstitution of human differentiation program of quail myogenic cells, 426 myoglobin, 5681 Nucleotide sequence of two overlapping myc-related genes in avian carcinoma virus OK10 and their relation to the myc genes of other Myopathy viruses and the cell, 2718 Biochemical rationale and the cardiac response of patients with muscle Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected disease to therapy with coenzyme Q1o, 4513 with ras or myc oncogenes, 3535 Cell-type-specific pattern of myc protooncogene expression in developing Myosin human embryos, 5050 Identification of an active site peptide of skeletal myosin after Heparin-treated, v-myc-transformed chicken heart mesenchymal cells photoaffinity labeling with N-(4-azido-2-nitrophenyl)-2-aminoethyl assume a normal morphology but are hypersensitive to epidermal diphosphate, 1575 growth factor (EGF) and brain fibroblast growth factor (bFGF); cells Fraction of myosin cross-bridges bound to actin in active muscle fibers: transformed by the v-Ha-ras oncogene are refractory to EGF and Estimation by fluorescence anisotropy measurements, 8478 bFGF but are hypersensitive to insulin-like growth factors, 5781 Myosin heavy chain The specific induction of myc protooncogene expression in normal Cloning and characterization of a nonmuscle myosin heavy chain human B cells is not a sufficient event for acquisition of competence to 6807 proliferate, 6255 cDNA, Myosin heavy chain gene Mycobacterinum paratberculosis Transposition of Tcl in the nematode Caenorhabditis elegans, 1756 A glycolipid antigen specific to Mycobacterium paratuberculosis: Genes for skeletal muscle myosin heavy chains are clustered and are not Structure and antigenicity, 3068 located on the same mouse chromosome as a cardiac myosin heavy Mycobacteriwn tuberculosis chain gene, 7183 Dissection of Mycobacterium tuberculosis antigens using recombinant Myosin light chain DNA, 2583 Developmental variations in the splicing pattern of transcripts from the Arthritis induced by a T-lymphocyte clone that responds to Drosophila gene encoding myosin aikali light chain result in different Mycobacterium tuberculosis and to cartilage proteoglycans, 5117 carboxyl-terminal amino acid sequences, 449 Mycoplasma Myosin light chain kinase Construction of the mycoplasma evolutionary tree from 5S rRNA Identification of the calmodulin-binding domain of skeletal muscle myosin sequence data, 1160 light chain kinase, 3187 Mycoplasma capricolum UGA is read as tryptophan in Mycoplasma capricolum, 2306 Myosin, nonmuscle Cloning and characterization of a nonmuscle myosin heavy chain Mycoside C cDNA, 6807 A glycolipid antigen specific to Mycobacterium paratuberculosis: Structure and antigenicity, 3068 Myosin subfragment 1 Stabilization of a primary loop in myosin subfragment 1 with a Myelin fluorescent crosslinker, 1658 Characterization of cultured rat oligodendrocytes proliferating in a Structure of the actin-myosin complex in the presence of ATP, 3247 serum-free, chemically defined medium, 3509 Phylogenetic dichotomy of nerve glycosphingolipids, 6779 Myotube Activity regulates the levels of acetylcholine receptor a-subunit mRNA in Myelin antibody cultured chicken myotubes, 4558 Anti-peripheral myelin antibody in patients with demyelinating neuropathy: Quantitative and kinetic determination of serum antibody Myristic add by complement component 1 fixation, 905 Fine structural mapping of a critical NH2-terminal region of p60Y'c, 1623 Mutation of NH2-terminal glycine of p60s prevents both myristoylation Myelin-associated glycoprotein and morphological transformation, 4625 Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood, 552 Myxococcus xanthus Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently "Frizzy" genes of Myxococcus xanthus are involved in control of antigens for IgM paraproteins, 6697 frequency of reversal of gliding motility, 8767 Myelin glycoprotein N gene Differentiation-specific regulation of Schwann cell expression of the Evidence that ribosomal protein S10 itself is a cellular component major myelin glycoprotein, 5987 necessary for transcription antitermination by phage X N protein, 4070 Myeloid cell N-myc gene Specific expression of the human cellularfps/fes-encoded protein NCP92 N-myc amplification in multiple homogeneously staining regions in two in normal and leukemic myeloid cells, 2379 human neuroblastomas, 3736 Differential amplification, assembly, and relocation of multiple DNA Myelolymphopoletic progenitor sequences in human neuroblastomas and neuroblastoma cell lines, 3761 Identification of B cells in multilineage hematopoietic colonies derived can with ras to transform normal cells in 5455 from cells of patients with lymphocytic lymphoma, 883 N-myc cooperate culture, N-ras gene Myeloproliferative sarcoma virus Activation of an N-ras gene in acute myeloblastic leukemia through Long terminal repeat sequences impart hematopoietic transformation somatic mutation in the first exon, 879 properties to the myeloproliferative sarcoma virus, 5746 Loss of the normal N-ras allele in a mouse thymic lymphoma induced by Myoblast a chemical carcinogen, 7810 Correlation between fusion and the developmental regulation of NAD membrane glycoproteins in L6 myoblasts, 8409 Inactivation of S-adenosyl-L-homocysteine hydrolase by cAMP results Myocardium from dissociation of enzyme-bound NAD', 4578 The hemodynamic destruction of intravascular cancer cells in relation to Photoaffinity labeling of diphtheria toxin fragment A with NAD: myocardial metastasis, 5737 Structure of the photoproduct at position 148, 7237 Myocyte NADPH Enkephalins have a direct positive inotropic effect on cultured cardiac The NADPH binding site on beef liver catalase, 1604 5930 myocytes, NADPH-ctochrome P450 oxddoreductase cDNA Myoepithelium Coding nucleotide sequence of rat NADPH-cytochrome P-450 Monoclonal antibody that defines human myoepithelium, 7409 oxidoreductase cDNA and identification of flavin-binding domains, 973 Myogenesis Nalidixic add Distinctive effects of the viral oncogenes myc, erb, fps, and src on the Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: differentiation program of quail myogenic cells, 426 The target of the drugs is DNA, 307 Subject Index Proc. Nadl. Acad. Sci. USA 82 (1985) 8909

Naphthalene Nerve, renal Catabolism of premercapturic acid pathway metabolites of naphthalene to Intravenous cyclosporine activates afferent and efferent renal nerves and naphthols and methylthio-containing metabolites in rats, 668 causes sodium retention in innervated kidneys in rats, 8222 Naphthol Nerve, sciatic Catabolism of premercapturic acid pathway metabolites of naphthalene to Differential effects of electrical stimulation of sciatic nerve on metabolic naphthols and methylthio-containing metabolites in rats, 668 activity in spinal cord and dorsal root ganglion in the rat, 6010 Nasal spray Nerve,sural Nasal absorption of insulin: Enhancement by hydrophobic bile salts, 7419 Capillary number and percentage closed in human diabetic sural nerve, 2513 Natural killer cell Murine monoclonal antibodies to the myelin-associated glycoprotein react Nerve,trnsected with large granular lymphocytes of human blood, 552 Differentiation-specific regulation of Schwann cell expression of the Natural killer cell recopition of target cells expressing different antigens major myelin glycoprotein, 5987 of vesicular stomatitis virus, 2456 Regulation of cellular function by products of lysosomal enzyme activity: Nervous system, central Elimination of human natural killer cells by a dipeptide methyl ester The postsynaptic density: A possible role in long-lasting effects in the generated from L-leucine methyl ester by monocytes or central nervous system, 3494 polymorphonuclear leukocytes, 2468 Evidence that receptors mediating central synaptic potentials extend Natural killer cell recognition of target cells expressing different antigens beyond the postsynaptic density, 3504 of vesicular stomatitis virus (Correction), 5578 Nervous system, echinoderm Phorbol ester induces a differential effect on the effector function of Nerves in the spine of a sea urchin: A neglected division of the human allospecific cytotoxic T lymphocyte and natural killer echinoderm nervous system, 1555 6642 clones, Netropsin Ncan gene The molecular origin of DNA-drugspecificity in netropsin and Chromosomal location of the gene encoding the neural cell adhesion distamycin, 1376 molecule (N-CAM) in the mouse, 7631 Sequence-specific recognition of B-DNA by oligo(N-methyl- pyrrolecarboxamide)s, 2565 NC pr Specific expression of the human cellularfps/fes-encoded protein NCP92 Network regulation in normal and leukemic myeloid cells, 2379 Antigen induces chronic idiotype suppression, 4217 Nebula NGC 6537 Neural development Spectrum and chemical composition of the remarkable planetary nebula Chromosomal location of the gene encoding the neural cell adhesion NGC 6537, 2202 molecule (N-CAM) in the mouse, 7631 Necrosin Neurite Cloning and expression in Escherichia coli of the cDNA for murine Insulin, insulin-like growth factorII, and nerve growth factor effects on tumor necrosis factor, 6060 tubulin mRNA levels and neurite formation, 7126 Negative selection Neurite extension factor In vivo separation of two classes of T cells as determined by negative Purification and characterization of a neurite extension factor from selection after the injection of UV-treated allogeneic lymphoid bovine brain, 7136 cells, 5136 Neuriteflatlon external Neisseria gonorrhoeac Involvement of the nerve growth factor-inducible large Antibodies to peptides corresponding to a conserved sequence of glycoprotein (NILE) in neurite fasciculation in primary cultures ofrat gonococcal pilins block bacterial adhesion, 915 brain, 1276 Neurit outgowtI Neisseria menivsgidis Peripheral-type benzodiazepines influence ornithine levels NZB mouse system for production of monoclonal antibodies to weak decarboxylase bacterial antigens: Isolation of an IgO antibody to the polysaccharide and neurite outgrowth in PC12 cells, 5223 capsules of Escherichia coli Ki and group B meningococci, 1194 Neuri outowth-promotlng tector Laminin is associated with the "neurite outgrowth-promoting factors" neo gene found in conditioned media, 2183 Isolation of embryonal carcinoma cell lines that express integrated recombinant genes flanked by the Moloney murine leukemia virus long Neurite, sensory terminal repeat, 2422 Nerves in the spine of a sea urchin: A neglected division of the echinoderm nervous system, 1555 Neoantigen Human plasma kallikrein and CT inhibitor form a complex possessing an Neuroblastoma epitope that is not detectable on the parent molecules: Demonstration Differential amplification, assembly, and relocation of multiple DNA using a monoclonal antibody, 5190 sequences in human neuroblastomas and neuroblastoma cell lines, 3761 Cell surface antigen of human neuroblastomas is related to nuclear Neocarzinostatin antigen of normal cells, 6894 Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at Increased pp60>"¢ tyrosyl kinase activity in human neuroblastomas is cytosine residues in DNA: Evidence for a possible role in associated with amino-terminal tyrosine phosphorylation of the src mutagenesis, 3182 gene product, 7275 Neocortes Neuroblastoma cell Anatomical correlates of the distribution of the pathological changes in Neuronal traits of clonal cell lines derived by fusion of dorsal root the neocortex in Alzheimer disease, 4531 ganglia neurons with neuroblastoma cells, 3499 a-Neoendorphin Neuroblastoma-gioma hybrid cell Sequence and expression of the rat prodynorphin gene, 4291 Characterization of 5-D-pjenici lamine]enkephalin binding toa opiate[3HI[2-D-penicillamine,receptors in the rat brain and neuroblastoma-glioma Neoplasm, T-cell hybrid cell line (NG 108-15), 2543 T-cell receptor gene rearrangements as markers of lineage and clonality Purification of the opiate receptor of NG108-15 neuroblastoma-ioma in T-cell neoplasms, 3460 hybrid cells, 4974 Nephrosls Neuroendocrlne Localization of sialic acid in kidney glomeruli: Regionalization in the Biochemical and immunological evidence for a cardiodilatin-like podocyte plasma membrane and loss in experimental nephrosis, 8508 substance in the snail neurocardiac axis, 7762 Nerve growth factor Neurofibrillary tangle Chromosomal locations of the human and mouse genes for precursors of Paired helical filaments from Alzheimer disease patients contain epidermal growth factor and the , subunit of nerve growth factor, 469 cytoskeletal components, 3916 Nerve growth factor rapidly induces ornithne decarboxylase mRNA in Anatomical correlates of the distribution of the pathological changes in PC12 rat pheochromocytoma cells, 5761 the neocortex in Alzheimer disease, 4531 Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles, 7111 Neurofflament Insulin, insulin-like growth factor II, and nerve growth factor effects on Giant axonal neuropathy: Acceleration of neurofilament transport in optic tubulin mRNA levels and neurite formation, 7126 axons, 920 Induction of the proto-oncogene fos by nerve growth factor, 7330 Aberrant neurofilament phosphorylation in Alzheimer disease, 4274 Nerve growth factor promotes cholinergic development in brain striatal Differential expression of intermediate filament proteins distinguishes cultures, 7777 classic from variant small-cell lung cancer cell lines, 4409 Nerve growth factor-indudble large external glycoprotein Neurofilament protein Involvement of the nerve growth factor-inducible large external The 200- and 150-kDa neurofilament proteins react with IgG glycoprotein (NILE) in neurite fasciculation in primary cultures of rat autoantibodies from patients with kuru, Creutzfeldt-Jakob disease, and brain, 1276 other neurologic diseases, 3485 8910 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

The 200- and 150-kDa neurofilament proteins react with IgG Accurate transcription of cloned Neurospora RNA polymerase autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob 11-dependent genes in vitro by homologous soluble extracts, 5450 disease; A 62-kDa neurofilament-associated protein reacts with sera DNA methylation at asymmetric sites is associated with numerous from sheep with natural scrapie, 3894 transition mutations, 8114 Accurate transcription of cloned Neurospora RNA polymerase Neurogenesis II-dependent genes in vitro by homologous soluble extracts Ontogeny of electrically excitable cells in cultured olfactory (Correction), 8274 epithelium, 7782 Neurotransmitter Neurokinin B Phorbol ester effects on neurotransmission: Interaction with Neurokinin B is a preferred agonist for a neuronal substance P receptor neurotransmitters and calcium in smooth muscle, 604 and its action is antagonized by enkephalin, 7444 A& and K opioids inhibit transmitter release by different mechanisms, 1860 Neuroleptic drug N-Acetylaspartylglutamate: Possible role as the neurotransmitter of the Neuroleptic drugs attenuate calcium influx and tension development in lateral olfactory tract, 3897 rabbit thoracic aorta: Effects of pimozide, penfluridol, chlorpromazine, Sympathetic neuron density differentially regulates transmitter and haloperidol, 1237 phenotypic expression in culture, 4296 Neuromodulation Neurotransmitter quanta Long-opening mode of gating of neuronal calcium channels and its Quantal mechanism of long-term synaptic potentiation, 5978 promotion by the dihydropyridine calcium agonist Bay K 8644, 2178 Neurotransmitter release Transmission at voltage-clamped giant synapse of the squid: Evidence for Neuromuscular junction cooperativity of presynaptic calcium action, 622 Is an acetylcholine transport system responsible for nonquantal release of Intraterminal injection of synapsin I or calcium/calmodulin-dependent acetylcholine at the rodent myoneural junction?, 3514 protein kinase II alters neurotransmitter release at the squid giant Neuron synapse, 3035 Vasoactive intestinal peptide-containing neurons in the paraventricular nucleus may participate in regulating prolactin secretion, 245 Neurotrophic factor Interaction of synaptic modification rules within populations of Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurons, 1291 neurotrophic factor for maintenance of acetylcholinesterase and From monoclonal antibody to gene for a neuron-specific glycoprotein in butyrylcholinesterase in the preganglionically denervated superior Drosophila, 1855 cervical ganglion of the cat in vivo, 5213 Neuronal traits of clonal cell lines derived by fusion of dorsal root Neutral mutation theory ganglia neurons with neuroblastoma cells, 3499 Evidence for higher rates of nucleotide substitution in rodents than in Inhibition of Ca2+ conductance in identified leech neurons by man, 1741 benzodiazepines, 3935 Adenosine-activated potassium conductance in cultured striatal Neutron diffraction neurons, 4857 A neutron diffraction study on the location of the polyene chain of retinal Microtubule-associated protein 1B: Identification of a major component in bacteriorhodopsin, 3227 of the neuronal cytoskeleton, 5404 Regional distribution of calcium influx into bursting neurons detected Neutrophil with arsenazo III, 5565 Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils Serotonin neurons on the ventral brain surface, 7449 with a GTP-binding protein sensitive to pertussis toxin, 869 Cytotactin, an extracellular matrix protein of neural and non-neural Circulating hydroxy fatty acids in familial Mediterranean fever, 1232 tissues that mediates glia-neuron interaction, 8075 Leukotriene B5 is formed in human neutrophils after dietary Differentiation of neuronal growth cones: Specialization of filopodial tips supplementation with icosapentaenoic acid, 1540 for adhesive interactions, 8256 Selective enhancement of the expression of granulocyte functional antigens 1 and 2 on human neutrophils, 2503 Neuron, cerebral cortical Respiratory burst oxidase from human neutrophils: Purification and some Vasoactive intestinal polypeptide acts synergistically with norepinephrine properties, 3144 to depress spontaneous discharge rate in cerebral cortical Modes of action of aspirin-like drugs, 7227 neurons, 8810 Human monocyte-endothelial cell interaction in vitro, 8208 Stimulation of the adherence of neutrophils to umbilical vein endothelium Neuron density by human recombinant tumor necrosis factor, 8667 Sympathetic neuron density differentially regulates transmitter Neutral endopeptidase 24.11 in human neutrophils: Cleavage of phenotypic expression in culture, 4296 chemotactic peptide, 8737 Neuron differentiation Newcastle disease virus Monoclonal antibody 18B8 detects gangliosides associated with neuronal Identification of individual interferon-producing cells by in situ differentiation and synapse formation, 4008 hybridization, 1136 Neuron, pyramidal Selection of unique antigenic variants of Newcastle disease virus with Signal enhancement in distal cortical dendrites by means of interactions neutralizing monoclonal antibodies and anti-immunoglobulin, 7106 between active dendritic spines, 2192 Nick-tranatibn Protein kinase C regulates ionic conductance in hippocampal pyramidal Nick-translation of metaphase chromosomes: In vitro labeling of neurons: Electrophysiological effects of phorbol esters, 2538 nuclease-hypersensitive regions in chromosomes, 854 Neuron, sensory Nicotana Associative conditioning analog selectively increases cAMP levels of tail Interspecific chloroplast recombination in a Nicotiana somatic sensory neurons in Aplysia, 2548 hybrid, 6960 Neuronal differentiation factor Nicatian tabacum Purification and partial characterization of a cholinergic neuronal Efficient induction and selection of chloroplast-encoded differentiation factor, 8795 antibiotic-resistant mutants in Nicotiana, 1485 Neuropathy Developmentally regulated expression of the bean P-phaseolin gene in Experimental diabetic neuropathy: Impairment of slow transport with tobacco seed, 3320 changes in axon cross-sectional area, 7716 Nicotinamide Neuropeptide Photoaffinity labeling of diphtheria toxin fragment A with NAD: The small cardioactive peptides A and B of Aplysia are derived from a Structure of the photoproduct at position 148, 7237 common precursor molecule, 3925 Nienann-Pick disease Transferrin receptors in rat brain: Neuropeptide-like pattern and A defect in cholesterol esterification in Niemann-Pick disease (type C) relationship to iron distribution, 4553 patients, 8247 Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzyme, 4745 nsf gene Azotobacter vinelandii n#D- and naE-encoded polypeptides share Neuropeptide biosynthesis structural homology, 5720 Precursor forms of substance P (SP) in nervous tissue: Detection with antisera to SP, SP-Gly, and SP-Gly-Lys, 4832 NqWpostronylus brasiensis Precursor forms of substance P (SP) in nervous tissue: Detection with B cells t-hat simultaneously express surface IgM and IgE in antisera to SP, SP-Gly, and SP-Gly-Lys (Correction), 6722 Nippostrongylus brasiliensis-infected SJA/9 mice do not provide evidence for isotype switching without gene deletion, 511 Neuropeptide Y Depletion of mucosal mast cell protease by corticosteroids: Effect on Neuropeptide Y affects secretion of luteinizing hormone and growth intestinal anaphylaxis in the rat, 1214 hormone in ovariectomized rats, 561 Neuropeptide Y injected in the paraventricular hypothalamus: A Nitrate powerfl stimulant of feeding behavior, 3940 Molybdate reduction by Escherichia coli K-12 and its chl mutants, 227 Molybdate reduction by Escherichia coli K-12 and its chl mutants Neurospora crassa (Correction), 3532 Identification and chromosomal distribution of 5S rRNA genes in Nitrate storage and retrieval in Beta vulgaris: Effects of nitrate and Neurospora crassa, 2067 chloride on proton gradients in tonoplast vesicles, 3683 Distinct roles of putrescine and spermidine in the regulation of ornithine Isolation and properties of soybean [Glycine max (L.) Merr.] mutants decarboxylase in Neurospora crassa, 4105 that nodulate in the presence of high nitrate concentrations, 4162 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8911

Nitrate biosynthesis Norepinephrine Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and Evidence for widespread effects of noradrenaline on axon terminals in nitrate in response to Escherichia coli lipopolysaccharide, 7738 the rat frontal cortex, 945 Human class I alcohol dehydrogenases catalyze the oxidation of glycols Nitrite in the metabolism of norepinephrine, 4979 Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and External Ca-independent release of noradrenaline by sympathomimetics nitrate in response to Escherichia coli lipopolysaccharide, 7738 and its role in negative feedback modulation, 8775 Vasoactive intestinal polypeptide acts synergistically with norepinephrine Nitrogen-15 to rate in Confirmation of the assignment of the low-field proton resonance of depress spontaneous discharge cerebral cortical serine proteases by using specifically nitrogen-15 labeled enzyme, 7948 neurons, 8810 Norfloxacin Nitrogen fixation Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: Nodulin-24 gene of soybean codes for a peptide of the peribacteroid The target of the is 307 membrane and was generated by tandem duplication of a sequence drugs DNA, resembling an insertion element, 4157 Noyikov conjecture Primary structure of the soybean nodulin-35 gene encoding uricase II Group actions and higher 1297 localized in the peroxisomes of uninfected cells of nodules, 5040 signatures, Azotobacter vinelandii njfD- and ntfE-encoded polypeptides share N(3')pp(5')A activated intermediate structural homology, 5720 Cyclization of RNA 3'-terminal phosphate by cyclase from HeLa cells Nodulin-24 gene of soybean codes for a peptide of the peribacteroid proceeds via formation of N(3')pp(5')A activated intermediate, 1316 membrane and was generated by tanden duplication of a sequence resembling an insertion element (Correction), 6366 nth gene Endonuclease III mutants of Escherichia 474 Nitrogen metabolism (nth) coli, Regulation of expression from the glnA promoter of Bacillus subtilis nir gene requires the glnA gene product, 3375 Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria Transcription of glnA by purified Escherichia coli components: Core activate ginA transcription in vitro: Evidence that the ntrA product is a RNA polymerase and the products of glnF, glnG, and glnL, 8453 c factor, 7525 Nitrogenase Nuclear antigen Covalent modification of the iron protein of nitrogenase from Nuclear lamins and peripheral nuclear antigens during fertilization and Rhodospirillum rubrum by adenosine diphosphoribosylation of a embryogenesis in mice and sea urchins, 4727 specific arginine residue, 3173 Cell surface antigen of human neuroblastomas is related to nuclear antigen of normal cells, 6894 Nitrogenase reductase Identification and expression of a nuclear antigen from the genomic Nitrogenase reductase: A functional multigene family in Rhizobium region of the Jijoye strain of Epstein-Barr virus that is missing in its phaseoli, 1170 nonimmortalizing deletion mutant, P3HR-1, 7429 N-Nitrosodialkylamine Nuclear extract N-Nitrosodialkylamines do not function as substrates for liver Accurate initiation of rat ribosomal RNA gene transcription using a monoamine oxidase, 682 fractionated nuclear extract from normal liver and a hepatoma, 1059 NMR See also Nuclear magnetic resonance Nuclear gene 'Na and 39K NMR studies of ion transport in human erythrocytes, 1099 An unusual genetic code in nuclear genes of Tetrahymena, 2452 1H-Observe/13C-decouple spectroscopic measurements of lactate and Nuclear magnetic resonance glutamate in the rat brain in vivo, 1633 See also NMR NMR, iH In vivo solvent-suppressed localized hydrogen nuclear magnetic A iH NMR technique for observing metabolite signals in the spectrum of resonance spectroscopy: A window to metabolism?, 2148 perfused liver, 5246 Confirmation of the assignment of the low-field proton resonance of serine proteases by using specifically nitrogen-15 labeled enzyme, 7948 NMR homonudear editing 1H homonuclear editing of rat brain using semiselective pulses, 3115 Nuclear magnetic resonance, carbon-13 13C NMR studies of carbon metabolism in the hyphal fungus Aspergillus NMR, 31p nidulans, 14 Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy, 8747 Nuclear matrix In situ localization of DNA topoisomerase II, a major polypeptide nod gene component of the Drosophila nuclear matrix fraction, 4142 Induction of Rhizobium meliloti nodC expression by plant exudate requires nodD, 6609 Nudear membrane Murine interferon-p receptor-mediated endocytosis and nuclear Nodulation membrane binding, 3281 Isolation and properties of soybean [Glycine max (L.) Merr.] mutants that nodulate in the presence of high nitrate concentrations, 4162 Nuclear protein Conservation of nodulation genes between Rhizobium meliloti and a A widely distributed nuclear protein immunologically related to the slow-growing Rhizobium strain that nodulates a nonlegume host, 5841 microtubule-associated protein MAPi is associated with the mitotic Exopolysaccharide-deficient mutants of Rhizobium meliloti that form spindle, 1146 ineffective nodules, 6231 Deletion of 43 amino acids in the NH2-terminal half of the large tumor antige. n of simian virus 40 results in a non-karyophilic protein capable Nodulation gene of transforming established cells, 1891 Isolation and characterization of nodulation genes from Bradyrhizobium sp. (Vigna) strain IRc 78, 7379 Nuclease CleaYage of cruciform DNA structures by an activity from Nodulin Saccharomyces cerevisiae, 6445 Nodulin-24 gene of soybean codes for a peptide of the peribacteroid membrane and was generated by tandem duplication of a sequence Nuclease-hypersensitive site resembling an insertion element, 4157 Nick-translation of metaphase chromosomes: In vitro labeling of Primary structure of the soybean nodulin-35 gene encoding uricase H nuclease-hypersensitive regions in chromosomes, 854 localized in the peroxisomes of uninfected cells of nodules, 5040 A method for mapping intranuclear protein-DNA interactions and its Nodulin-24 gene of soybean codes for a peptide of the peribacteroid application to a nuclease hypersensitive site, 2296 membrane and was generated by tanden duplication of a sequence resembling an insertion element (Correction), 6366 Nudease, mung bean Mapping the location of psoralen crosslinks on RNA by mung bean Nondisjunction nuclease sensitivity of RNADNA hybrids, 1381 Analysis of DNA haplotypes suggests a genetic predisposition to trisomy 21 associated with DNA sequences on chromosome 21, 3360 Nudease S1 hypersensitivity Torsional stress induces an S1 nuclease-hypersensitive site within the Nonopoidd binding site promoter of the Xenopus laevis oocyte-type SS RNA gene, 4018 P-Endorphin: Surface binding and internalization in thymoma cells, 5751 Nudeic acid base Nonsteroidal anti-inflammatory drugs Ultraviolet resonance Raman excitation profiles of nucleic acid bases Modes of action of aspirin-like drugs, 7227 with excitation from 200 to 300 nanometers, 2369 Nontranscribed spacer Nucleic acid hybridization DNase I-resistant nontranscribed spacer segments of mouse ribosomal Base composition-independent hybridization in tetramethylammonium DNA contain poly(dG-dT)*poly(dA-dC), 7595 chloride: A method for oligonucleotide screening of highly complex gene libraries, 1585 19-Nor-10-keto-25-hydroxyvltamin P3 Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a Nucleogenesis metabolite that may induce differentiation of the human monoblastic Spectrum and chemical composition of the remarkable planetary nebula cell line U937, 8218 NGC 6537, 2202 8912 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Nucleolar organizer Chemosensory recognition of mouse major histocompatibility types by A stochastic mechanism controls the relative replication of equally another species, 4186 competent ribosomal RNA gene sets in individual dipteran polyploid nuclei, 5045 Olfactory epithelial cell Ontogeny of electrically excitable cells in cultured olfactory Nucleophilic substitution epithelium, 7782 Alternative view of enzyme reactions, 2225 Olfactory marker protein Nudeophilicity Olfactory neuron-specific protein is translated from a large poly(A)+ Driving force and nucleophilicity in SN2 displacements, 8288 mRNA, 5218 Nucleoprotein Olfactory tract Influenza A virus nucleoprotein is a major target antigen for N-Acetylaspartylglutamate: Possible role as the neurotransmitter of the cross-reactive anti-influenza A virus cytotoxic T lymphocytes, 1785 lateral olfactory tract, 3897 Nudeoprotein complex (2'-S')Olgoadenylate synthetase Specific transcription of preformed nucleoprotein complexes, containing Interferon regulates c-myc gene expression in Daudi cells at the the adenovirus major late promoter, with a chromatographic fraction post-transcriptional level, 1151 containing RNA polymerase II, 6769 Oligodendrocyte Nucleoside analog Characterization of cultured rat oligodendrocytes proliferating in a Metabolic activation of the nucleoside analog 9-4[2-hydroxy-1- serum-free, chemically defined medium, 3509 (hydroxymethyl)ethoxy]methyl}guanine in human diploid fibroblasts Transferrin gene expression visualized in oligodendrocytes of the rat infected with human cytomegalovirus, 2473 brain by using in situ hybridization and immunohistochemistry, 6706 Nudeosidetriphosphatase Olgodendroglia Escherichia coli transcription termination factor p has a two-domain Peptides from regenerating central nervous system promote specific structure in its activated form, 1911 populations of macroglia, 4287 Nucleosome Oligodeoxyribonucleotide Differential scanning calorimetry of nuclei reveals the loss of major Site-specifically modified oligodeoxyribonucleotides as templates for structural features in chromatin by brief nuclease treatment, 2642 Escherichia coli DNA polymerase I, 2325 Genetic rearrangement of DNA induces knots with a unique topology: Implications for the mechanism of synapsis and crossing-over, 3124 Oligomycin Nucleosome-core particles suppress the thermal untwisting of core DNA Mechanism of inhibition of mitochondrial adenosine triphosphatase by and adjacent linker DNA, 4653 dicyclohexylcarbodiimide and oligomycin: Relationship to ATP synthesis, 1589 Nucleotlde-bimding domain Structure of the human phosphoglycerate kinase gene and the Oligonucleotide, modified intron-mediated evolution and dispersal of the nucleotide-binding Modified oligonucleotides as alternatives to the synthesis of mixed domain, 6965 probes for the screening of cDNA libraries, 7510 Nucleotide binding site Oligonucleotide probe Investigation of nucleotide binding sites on chloroplast coupling factor 1 Cloning and expression of the human erythropoietin gene, 7580 with 3'-0-(4-benzoy1)benzoyl adenosine 5'-triphosphate, 1950 Oligonudeotide screening Locating a nucleotide-binding site in the thymidine kinase of vaccinia Base composition-independent hybridization in tetramethylammonium virus and of herpes simplex virus by scoring triply aligned protein chloride: A method for oligonucleotide screening of highly complex sequences, 6815 gene libraries, 1585 Nudeotide substitution Oligosaccharide Nucleotide sequence, evolution, and expression of the fetal globin gene Structural requirements for sulfation of asparagine-linked of the spider monkey Ateles geoffroyi, 6985 oligosaccharides of lutropin, 7850 Nucleotide substitution rate Evidence for higher rates of nucleotide substitution in rodents than in Oligosaccharide, O-linked 1741 Nucleotide sequence of the G protein gene of human respiratory man, syncytial virus reveals an unusual type of viral membrane protein, 4075 Nucleus, cell Regulated expression of endonuclease EcoRI and Saccharomyces OmpA protein cerevisiae: Nuclear entry and biological consequences, 1354 ATP is essential for protein translocation into Escherichia coli membrane A method for mapping intranuclear protein-DNA interactions and its vesicles, 4384 application to a nuclease hypersensitive site, 22% Prolactin induces release of a factor from membranes capable of ompR gene stimulating #-casein gene transcription in isolated mammary cell nuclei Deduced product of the stage 0 sporulation gene spoOF shares homology (Retraction), 3062 with the SpoOA, OmpR, and SfrA proteins, 7260 Identification of a nuclear localization signal of a yeast ribosomal Oncofetal antigen protein, 6561 Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder Gene gating: A hypothesis, 8527 tumor antigen induce specific cell-mediated tumor immunity, 6286 nus gene Oncofetal domain Defective antitermination of rRNA transcription and derepression of The oncofetal domain of fibronectin defined by monoclonal antibody rRNA and tRNA synthesis in the nusBS mutant of Escherichia FDC-6: Its presence in fibronectins from fetal and tumor tissues and its coli, 5275 absence in those from normal adult tissues and plasma, 6517 O protein Oncogene Specialized nucleoprotein structures at the origin of replication of Effects of two major activating lesions on the structure and conformation bacteriophage X: Complexes with X 0 protein and with X 0, X P, and of human ras oncogene products, 38 Escherichia coli DnaB proteins, 4678 Transcription of three c-myc exons is enhanced in chicken bursal Ochromonas danica lymphoma cell lines, 53 Ochromonas mitochondria contain a A retrovirual myc gene induces preneoplastic transformation of specific chloroplast protein, 1456 lymphocytes in a bursal transplantation assay, 222 Octo0 Distinctive effects of the viral oncogenes myc, erb, fps, and src on the Characterization of octopamine-sensitive adenylate cyclase: Elucidation differentiation program of quail myogenic cells, 426 of a class of potent and selective octopamine-2 receptor agonists with Comparison of chemically induced and spontaneous murine thymic toxic effects in insects, 599 lymphomas in RF and AKR mice: Differential expression of c-myc and c-myb, 565 Ocular dom ce Activation of an N-ras gene in acute myeloblastic leukemia through Intrinsic projections within visual cortex: Evidence for somatic mutation in the first exon, 879 orientation-specific local connections, 935 Expression of p21 in fresh primary and metastatic human colorectal tumors, 1795 Okazaki fragment Epidermal growth factor precursor is related to the translation product of Accumulation of 10-kilobase DNA replication intermediates in cells the Moloney sarcoma virus oncogene mos, 1921 treated with 3-aminobenzamide, 104 Chromatin structure around the c-myc gene in Burkitt lymphomas with upstream and downstream translocation points, 1984 Oleate Suppression of tumorigenicity in hybrids of normal and Isolation and partial characterization of a fatty acid binding protein in rat oncogene-transformed CHEF cells, 2062 liver plasma membranes, 4 c-erbB activation in avian leukosis virus-induced erythroblastosis: 1-Oleoyl-2-acetlglycerol Clustered integration sites and the arrangement of provirus in the Activators of protein kinase C down-regulate and phosphorylate the c-erbB alleles, 2287 T3/T-cell antigen receptor complex of human T lymphocytes, 8158 Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region, 2315 Olfaction Restriction fragment length polymorphism of the human c-fs gene, 2862 Isolation and characterization of an olfactory receptor protein for odorant Efficient generation of antibodies to oncoproteins by using synthetic pyrazines, 3050 peptide antigens, 3400 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8913

Rates of evolution of the retroviral oncogene of Moloney murine sarcoma Optially active biological structure virus and of its cellular homologues, 4198 Imaging of optically active biological structures by use of circularly Antibodies specific for amino acid 12 of the ras oncogene product inhibit polarized lit, 401 GTP binding, 5280 Molecular cloning of an activated human oncogene, homologous to v-rqf, Orbital from primary stomach cancer, 5641 Comparison of the theoretical and experimental values of the number of Detection of a raf-related and two other transforming DNA sequences in metallic orbitals per atom in hypoelectronic and hyperelectronic human tumors maintained in nude mice, 5954 metals, 8286 Mutagenesis of avian carcinoma virus MH2: Only one of two potential transforming genes (8gag-myc) transforms fibroblasts, 6389 Order parameter Multistep transformation by defined fragments of herpes simplex virus Fast and slow orientational fluctuations in membranes, 2029 type 2 DNA: Oncogenic region and its gene product, 8493 Oreochromis mossambicus Oncogene-related protein Isolation and partial characterization of a pair of prolactins released in Anti-peptide antibodies detect oncogene-related proteins in urine, 7924 vitro by the pituitary of a cichlid fish, Oreochromis mossambicus, 7490 Oncogenesis Organelle biogenesis Hybrid hepatitis B virus-host transcripts in a human hepatoma cell, 83 Peroxisomal organization in normal and cerebrohepatorenal (Zellweger) syndrome fibroblasts, 6556 Oncoprotein Efficient generation of antibodies to oncoproteins by using synthetic Organic solvent peptide antigens, 3400 Enzyme-catalyzed processes in organic solvents, 3192 Oncorhynchgs keta oriC gene Cloning and expression of cDNA for salmon growth hormone in Initiation of enzymatic replication at the origin of the Escherichia coli Escherichia coli, 4306 chromosome: Contributions of RNA polymerase and primase, 3562 Oncovirus type E Orientation Complete nucleotide sequence of the genome of bovine leukemia virus: Intrinsic projections within visual cortex: Evidence for Its evolutionary relationship to other retroviruses, 677 orientation-specific local connections, 935 O0cyte Origin of replication Growing Xenopus oocytes have spare translational capacity, 6586 Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in Oocyte maturation plasmid R6K, 1480 Hypoxanthine is the principal inhibitor of murine oocyte maturation in a A cosmid vector that facilitates restriction enzyme mapping, 3159 low molecular weight fraction of porcine follicular fluid, 454 A defective phage system reveals bacteriophage T4 replication origins that coincide with recombination hot spots, 3345 Oogenesls Monomers through trimers of large tumor antigen bind in region I and Biphasic pattern of histone gene expression during Drosophila monomers through tetramers bind in region II of simian virus 40 origin oogenesis, 3316 of replication DNA as stable structures in solution, 3626 Opacification Initiation of enzymatic replication at the origin of the Escherichia coli Opacification of y-crystallin solutions from calf lens in relation to cold chromosome: Primase as the sole priming enzyme, 3954 cataract 1701 Specialized nucleoprotein structures at the origin of replication of formation, bacteriophage X: Complexes with X 0 protein and with X 0, X P, and Opal termination Escherichia coli DnaB proteins, 4678 UGA is read as in 2306 In vitro replication of duplex circular DNA containing the simian virus 40 tryptophan Mycoplasma capricolum, DNA origin site, 5710 Operator Mutational studies with the trp repressor of Escherichia coli support the Ornlthine decarboxylase helix-turn-helix model of repressor recognition of operator DNA, 483 Nucleotide sequence of murine ornithine decarboxylase mRNA, 1673 Dominant negative mutations in the TnlO tet repressor: Evidence for the Role of protein kinase C in diacylglycerol-mediated induction of ornithine use of the conserved helix-turn-helix motif in DNA 6226 decarboxylase and reduction of epidermal growth factor binding, 1941 binding, Distinct roles of putrescine and spermidine in the regulation of ornithine Operator mutation - decarboxylase in Neurospora crassa, 4105 NH2-terminal arm of phage X repressor contributes energy and specificity Induction of ornithine decarboxylase activity by insulin and growth to repressor binding and determines the effects of operator factors is mediated by amino acids, 4365 mutations, 2339 Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neurite outgrowth in PC12 cells, 5223 Opiate Nerve growth factor rapidly induces ornithne decarboxylase mRNA in Morphine and other opiates from beef brain and adrenal, 5203 PC12 rat pheochromocytoma cells, 5761 Prevention of a plant disease by specific inhibition of fungal polyamine Opiate, enoenous biosynthesis, 6874 Isolation of morphine from toad skin, 1852 Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids (Correction), 8274 Opiate receptor Conformationally restricted analogs of somatostatin with high A-opiate Ornithine transcar oylse receptor specificity, 236 Arginine in the leader peptide is required for both import and proteolytic Purification and characterization of the M opiate receptor from rat brain cleavage of a mitochondrial precursor, 4930 using affinity chromatography, 594 Characterization of pH][2-D-pemcillamine, 5-D-jenicillaminejenkephalin Osmolarity binding to 8 opiate receptors in the rat brain and neuroblastoma-glioma Exclusive nuclear location of estrogen receptors in Squalus testis, 1336 hybrid cell line (NG 108-15), 2543 Purification of the opiate receptor of NG108-15 neuroblastoma-glioma Osteods hybrid cells, 4974 1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with Enkephalins have a direct positive inotropic effect on cultured cardiac several osteoclast characteristics in cultures of primate marrow, 8213 myocytes, 5930 Osteogeneis imperfecta Visualization of Al opiate receptors in rat brain by using a computerized Intron-mediated recombination may cause a deletion in an al type I autoradiographic subtraction technique, 6667 collagen chain in a lethal form of osteogenesis imperfecta, 2870 Oploid A and K opioids inhibit transmitter release by different mechanisms, 1860 Osteosarcoma Isolation, sequencing, synthesis, and pharmacological characterization of Osteosarcoma and retinoblastoma: A shared chromosomal mechanism two brain neuropeptides that modulate the action of morphine, 7757 revealing recessive predisposition, 6216 Opioid peptide Ouabaln P-Endorphin-(1-27) is a naturally occurring antagonist to Correlation of ouabain-sensitive ion movements with cell-cycle etorphine-induced analgesia, 3178 activation, 1599 Changes in plasma proenkephalin peptide F and catecholamine levels exercise in men, 6349 Ovary during graded Isolation and partial characterization of a Mr 32,000 protein with inhibin OpeSSm activity from porcine follicular fluid, 7217 Photoreactivation of UV-induced pyrimidine dimers and erythema in the Expression of preproenkephalin-like mRNA and its peptide products in marsupial Monodelphis domestica, 2409 mammalian testis and ovary, 7467 Opn Oviduct Tunicamycin blocks the incorporation of opsin into retinal rod outer Evidence for specific DNA sequences in the nuclear acceptor sites of the segment membranes, 1116 avian oviduct progesterone receptor, 4722 Optic nerve Ootransferrin gene Dispersion of growing axons within the optic nerve of the embryonic Organization of the human transferrin gene: Direct evidence that it monkey, 3906 originated by gene duplication, 3149 8914 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Ovulation Pacemaker cell Bioeffective monoclonal antibody against the decapeptide Ionic currents that generate the spontaneous diastolic depolarization in gonadotropin-releasing hormone: Reacting determinant and action on individual cardiac pacemaker cells, 7796 ovulation and estrus suppression, 1228 Packing, molecular Ovulation neurohormone Molecular packing and area compressibility of lipid bilayers, 6532 Purification and amino acid sequence of the ovulation neurohormone of Lymnaea stagnalis, 7767 Pad6 approximation Pad6 approximations and diophantine geometry, 2212 Oxddase Respiratory burst oxidase from human neutrophils: Purification and some Paleopathology properties, 3144 Immunological detection of hemoglobin in bones of ancient Roman times and of Iron and Eneolithic Ages, 7170 Oxidative phosphorylatlon Purified hydrophobic proteins, chargerins, are essential for energy Palindrome transduction in oxidative phosphorylation, 1331 Synthesis of sperm and late histone cDNAs of the sea urchin with a Mechanism of inhibition of mitochondrial adenosine triphosphatase by primer complementary to the conserved 3' terminal palindrome: dicyclohexylcarbodiimide and oligomycin: Relationship to ATP Evidence for tissue-specific and more general histone gene synthesis, 1589 variants, 5676 Oidmetry Pancreas Spin-label oximetry: Kinetic study of cell respiration using a Identification of calmodulin-dependent protein kinase HI and its major rapid-passage Tl-sensitive electron spin resonance display, 411 Mr 100,000 substrate in mammalian tissues, 7939 Oxirane Pancreatic polypeptide Rapid purification of cytosolic epoxide hydrolase from normal and Isolation of a cDNA clone encoding pancreatic polypeptide, 1536 clofibrate-treated animals by affinity chromatography, 1663 Pancreatic thread protein Oxygen An unusual bovine pancreatic protein exhibiting pH-dependent Spin-label oximetry: Kinetic study of cell respiration using a globule-fibril transformation and unique amino acid sequence, 5627 rapid-passage Tl-sensitive electron spin resonance display, 411 Papillomavirus Oxidative stress and protective mechanisms in erythrocytes in relation to Genomic structure of the cottontail rabbit (Shope) papillomavirus, 1580 Plasomodium vinckei load, 548 Expression of a functional influenza viral cap-recognizing protein by Oxygen chemoreception by carotid body cells in culture, 1448 using a bovine papilloma virus vector, 4326 Respiratory burst oxidase from human neutrophils: Purification and some Papillomavirus genomes in human cervical tumors: Analysis of their properties, 3144 transcriptional activity, 5540 Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear Paracrine leukocytes: Possible link between inflammation and cancer, 5194 Evidence for widespread effects of noradrenaline on axon terminals in Molecular mechanism of water oxidation in photosynthesis based on the the rat frontal cortex, 945 functioning of manganese in two different environments, 6119 Genetic differences in oxygen toxicity are correlated with cytochrome Paramagnetiam P-450 inducibility, 6315 Reexamination of the evidence for paramagnetism in oxy- and Oxygen binding properties of human mutant hemoglobins synthesized in carbonmonoxyhemoglobins, 102 Escherichia coli, 7252 Control of oxidative metabolism and oxygen delivery in human skeletal Paramyxovfrus muscle: A steady-state analysis of the work/energy An alternative route of infection for viruses: Entry by means of the cost transfer asialoglycoprotein receptor of a Sendai virus mutant lacking its function, 8384 attachment protein, 978 Oxyhemoglobin Paraprotein Reexamination of the evidence for paramagnetism in oxy- and Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently carbonmonoxyhemoglobins, 102 antigens for IgM paraproteins, 6697 P element Transformation of salivary gland secretion protein gene Sgs-4 in Parasite, intracellular Drosophila: Stage- and tissue-specific regulation, dosage compensation, Cloning and expression of the Rickettsia prowazekii ADP/ATP and position effect, 5055 translocator in Escherichia coli, 3015 P-element distribution in Eurasian populations of Drosophila Parasponia rda melanogaster: A genetic and molecular analysis, 5418 Conservation of nodulation genes between Rhizobium meliloti and a Structures of defective P transposable elements prevalent in natural Q slow-growing Rhizobium strain that nodulates a nonlegume host, 5841 and Q-derived M strains of Drosophila 6236 Sex- and cell-specific regulation of yolk polypeptidemelanoqaster,genes introduced Parathymosin a into Drosophila by P-element-mediated gene transfer, 7000 Parathymosin a: A peptide for rat tissues with structural homology to Rapid change in mutation rate in a local population of Drosophila prothymosin a, 1050 melanogaster, 7671 P-element distribution in Eurasian populations of Drosophila Parathyrold hormone melanogaster: A genetic and molecular analysis (Correction), 7802 Regulation of vitamin D metabolites of messenger ribonucleic acid for Transposase titration in Drosophila melanogaster: A model of cytotype preproparathyroid hormone in isolated bovine parathyroid cells, 4270 in the P-M system of hybrid dysgenesis, 8119 Calcium-regulating hormones modulate carbonic anhydrase II in the human erythrocyte, 8832 PL promoter M~aximizing gene expression from plasmid vectors containing the X PL Paratuberculosla promoter: Strategies for overproducing transcription termination factor A glycolipid antigen specific to Mycobacterium paratuberculosis: p, 88 Structure and antigenicity, 3068 p21 protein Paraventricular nucleus Effects of two major activating lesions on the structure and conformation Vasoactive intestinal peptide-containing neurons in the paraventricular of human ras oncogene products, 38 nucleus may participate in regulating prolactin secretion, 245 Ha-ras proteins exhibit GTPase activity: Point mutations that activate Ha-ras gene products result in decreased GTPase activity, 376 Parkinsonism Expression of p21m in fresh primary and metastatic human colorectal Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6- tumors, 1795 tetrahydropyridine: Uptake of the metabolite N-methyl-4- Structural effects of substitutions on the p21 proteins, 3596 phenylpyridine by dopamine neurons explains selective toxicity, 2173 Antibodies specific for amino acid 12 of the ras oncogene product inhibit Paromomycin GTP binding, 5280 A drug-resistant mutation in the ribosomal DNA of Tetrahymena, 2844 p24 core protein Parotid gland Monoclonal antibodies specific for p24, the major core protein of human The rate-determining step in cAMP-mediated exocytosis in the rat parotid T-cell leukemia virus type III, 5199 and submandibular glands appears to involve analogous 26-kDa integral membrane phosphoproteins, 3237 p24 gag protein Bacterial expression of the acquired immunodeficiency syndrome Paroxysmal nocturnal hemoglobinuria retrovirus p24 gag protein and its use as a diagnostic reagent, 7748 Enhanced complement-mediated lysis of type III paroxysmal nocturnal hemoglobinuria erythrocytes involves increased C9 binding and p36 protein polymerization, 5520 Amino-terminal sequence of p36 and associated p10: Identification of the site of tyrosine phosphorylation and homology with S-100, 7884 Parvalbumin The Ca2+-binding protein parvalbumin: Molecular cloning and p60e pro- developmental regulation of mRNA abundance, 1414 Fine structural mapping of a critical NH2-terminal region of p60&', 1623 The neostriatal mosaic: Compartmental distribution of calcium-binding Mutation of NH2-terminal glycine of p60'- prevents both myristoylation protein and parvalbumin in the basal ganglia of the rat and and morphological transformation, 4625 monkey, 8780 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8915 pat) gene Perforin Negative control for the initiation of meiosis in Schizosaccharomyces Isolation and biochemical and functional characterization of perforin 1 pombe, 2447 from cytolytic T-cell granules, 8629 Pathogenesis Perhydroantamanide Cloning determinants of pathogenesis from Pseudomonas syringae Lithium perhydroantamanide complex (2:1): Exposure of the peptide pathovar syringae, 406 backbone in the analog of antamanide with antitoxic impotency, 7155 Pathogenesis-related protein Peritubular cell Synthesis of pathogenesis-related proteins in tobacco is regulated at the Testicular peritubular cells secrete a protein under androgen control that level of mRNA accumulation and occurs on membrane-bound modulates Sertoli cell functions, 114 polysomes, 7999 Permeability Pattern score H The Ca channel in skeletal muscle is a large pore, 7149 Significance of similarities in patterns: An application to , DNA on human chromosome 2, 4090 Permease, lactose interferon-related Site-specific mutagenesis of histidine residues in the lac permease of PC-1 membrane antigen Escherichia coli, 6765 Murine plasma cell membrane antigen PC-1: Molecular cloning of cDNA and analysis of expression, 8619 Peroxidation Essential role of phospholipase A2 activity in endothelial cell-induced Peanut agglutinin modification oflow density lipoprotein, 3000 Bone marrow engraftment efficiency is enhanced by competitive of the hepatic asialoglycoprotein receptor, 2508 Peroxide inhibition Peroxide-producing potential of tissues: Inverse correlation with Peanut stunt virus longevity of mammalian species, 4798 Nucleotide sequence of the satellite of peanut stunt virus reveals structural homologies with viroids and certain nuclear and Peroxisome introns, 3110 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in mitochondrial peroxisomes in normal rat liver cells, 770 Penfluridol Cloning of cDNA coding for peroxisomal acyl-CoA oxidase from the Neuroleptic drugs attenuate calcium influx and tension development in yeast Candida tropicalis pK233, 3973 rabbit thoracic aorta: Effects of pimozide, penfluridol, chlorpromazine, Primary structure of the soybean nodulin-35 gene encoding uricase II and haloperidol, 1237 localized in the peroxisomes of uninfected cells of nodules, 5040 Peroxisomal organization in normal and cerebrohepatorenal (Zellweger) D-Penlicllamine syndrome fibroblasts, 6556 Characterization of [3H][2-D-jpenicillamine, 5-D-penicillamine]enkephalin binding to 8 opiate receptors in the rat brain and neuroblastoma-glioma Perturbation, minimum hybrid cell line (NG 108-15), 2543 Structure of proteins with single-site mutations: A minimum perturbation approach, 1697 Penicillin-binding protein Sequences of the active-site peptides of three of the high-Mr Pertussis toxin penicillin-binding proteins of Escherichia coli K-12, 1999 Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils Penicillin binding proteins: Role in initiation of murein synthesis in with a GTP-binding protein sensitive to pertussis toxin, 869 Escherichia coli, 5632 Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line, 2637 Pep MS protein Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated Presence of two distinct regions in the coiled-coil structure of the changes in rabbit neutrophils: Role of G proteins in excitation response streptococcal Pep M5 protein: Relationship to mammalian coiled-coil coupling, 2708 proteins and implications to its biological properties, 1064 Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human Pepper leukemic (HL-60) cells, 3277 Isolation and characterization of an olfactory receptor protein for odorant A pertussis toxin-sensitive GTP-binding protein in the human neutrophil pyrazines, 3050 regulates multiple receptors, calcium mobilization, and lectin-induced Pepsinogen gene capping, 8643 Variable numbers of pepsinogen genes are located in the centromeric Pertussis toxin is required for pertussis vaccine encephalopathy, 8733 region of human chromosome 11 and determine the high-frequency Petunia electrophoretic polymorphism, 6240 Linkage and homology analysis divides the eight genes for the small Peptidase subunit of petunia ribulose 1,5-bisphosphate carboxylase into three Immunochemical characterization of carboxypeptidase B-like gene families, 4964 peptide-hormone-processing enzyme, 4745 pgsA gene Peptide Genetic manipulation of membrane phospholipid composition in Brain-specific polypeptide 1B236 exists in multiple molecular forms, 2009 Escherichia coli: pgsA mutants defective in phosphatidylglycerol synthesis, 7530 Peptide backbone Lithium perhydroantamanide complex (2:1): Exposure of the peptide pH backbone in the analog of antamanide with antitoxic impotency, 7155 See also Acid Characterization of the activation of Na+/H+ exchange in lymphocytes Peptide chain release factor by phorbol esters: Change in cytoplasmic pH dependence of the Bacterial peptide chain release factors: Conserved primary structure and antiport, 1429 possible frameshift regulation of release factor 2, 3616 Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells, 1736 Peptide, ectopic Ionic responses rapidly elicited by activation of protein kinase C in Ectopic peptides released by a human melanoma cell line that modulate quiescent Swiss 3T3 cells, 2384 the transformed phenotype, 5015 Susceptibility of human malaria parasites to chloroquine is pH Peptide-peptide interaction dependent, 2784 Similarity between the corticotropin (ACTH) receptor and a peptide Phage encoded by an RNA that is complementary to ACTH mRNA, 1372 See Bacteriophage Peptide substrate, synthetic Phate A synthetic peptide substrate specific for casein kinase II, 737 Respiratory burst oxidase from human neutrophils: Purification and some Peptide synthesis properties, 3144 esmall peptides induce antibodies with a sequence and structural Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a requirement for binding antigen comparable to antibodies raised against metabolite that may induce differentiation of the human monoblastic the native protein, 178 cell line U937, 8218 Semisynthesis of horse heart cytochrome c analogues from two or three Phagotosis fragments, 8279 Presence of two distinct regions in the coiled-coil structure of the Peptide synthei, solid-phase streptococcal Pep MS protein: Relationship to mammalian coiled-coil Molecular cloning, cD)NA sequencing, and chemical synthesis of cecropin proteins and implications to its biological properties, 1064 B from Hyalophora cecropia, 2240 Relationship of M protein genes in group A streptococci, 1822 General method for the rapid solid-phase synthesis of large numbers of Generation of leukotrienes by human monocytes upon stimulation of peptides: Specificity of antigen-antibody interaction at the level of their ,-glucan receptor during phagocytosis, 2751 individual amino acids, 5131 3-Deazaadenosine-induced disorganization of macrophage microfilaments, 4060 Peptidoglycan transpeptidase Sequences of the active-site peptides of three of the high-M, Phase-change inetics penicillin-binding proteins of Escherichia coli K-12, 1999 Phase-change kinetics for a microtubule with two free ends, 431 Peptidyl site Phase variation A second tRNA binding site on elongation factor Tu is induced while the An invertible element of DNA controls phase variation of type 1 fimbriae factor is bound to the ribosome, 3212 of Escherichia coli, 5724 8916 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Phaseolin 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of Expression of phaseolin cDNA genes in yeast under control of natural inositol phosphates in human platelets: Possible implications for plant DNA sequences, 334 negative feedback regulation of inositol phospholipid hydrolysis, 2623 Phorbol esters induce transient internalization without degradation of 3-Phaseolin gene unoccupied epidermal growth factor receptors, 2774 Developmentally regulated expression of the bean P-phaseolin gene in Platelet-derived growth factor mimics phorbol diester action on epidermal tobacco seed, 3320 growth factor receptor phosphorylation at threonine-654, 4080 Phaseolus vdgaris Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol Cloning determinants of pathogenesis from Pseudomonas syringae ester, 4369 pathovar syringae, 406 Phorbol esters promote a1-adrenergic receptor phosphorylation and Developmentally regulated expression of the bean ,-phaseolin gene in receptor uncoupling from inositol phospholipid metabolism, 5651 tobacco seed, 3320 Demonstration of a stimulatory protein for virus-specified DNA Accumulation of hydroxyproline-rich glycoprotein mRNAs in response to polymerase in phorbol ester-treated Epstein-Barr virus-carrying fungal elicitor and infection, 6551 cells, 5728 Rapid transient induction of phenylalanine ammonia-lyase mRNA in Acetylcholine and phorbol esters inhibit potassium currents evoked by elicitor-treated bean cells, 6731 adenosine and cAMP in Xenopus oocytes, 6001 Regulation of ribulose bisphosphate carboxylase activity in vivo by a light-modulated inhibitor Phorbol 12-myristate 13-acetate of catalysis, 8024 Effects of phorbol ester on catecholamine secretion and protein Phe-Met-Arg-Phe-NH2 phosphorylation in adrenal medullary cell cultures, 930 Peptidergic modulation of patterned motor activity in identified neurons Identification and partial characterization of hepatocyte-stimulating factor of Helisoma, 7140 from leukemia cell lines: Comparison with interleukin 1, 1443 Isolation, sequencing, synthesis, and pharmacological characterization of Correlation of ouabain-sensitive ion movements with cell-cycle two brain neuropeptides that modulate the action of morphine, 7757 activation, 1599 Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization Phencyclidine and phosphatidylinositol 4,5-bisphosphate hydrolysis in human Demonstration and affinity labeling of a stereoselective binding site for a platelets, 3859 benzomorphan opiate on acetylcholine receptor-rich membranes from Phorbol 12-myristate 13-acetate and insulin increase the concentration of Torpedo electroplaque, 940 fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts, 6440 Phenotype modulation Phorbol ester induces a differential effect on the effector function of Arterial smooth muscle cells in primary culture produce a human allospecific cytotoxic T lymphocyte and natural killer platelet-derived growth factor-like protein, 4418 clones, 6642 Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma Phenotypic choice virus transforming protein, serum, or phorbol ester, 7621 Purifiocation and partial characterization of a cholinergic neuronal Activation of Na+/H+ exchange in cultured fibroblasts: Synergism and differentiation factor, 8795 antagonism between phorbol ester, Ca2+ ionophore, and growth Phenotypic state factors, 8053 Expected time for random genetic drift of a population between stable Phosmid phenotypic states, 7641 A cosmid vector that facilitates restriction enzyme mapping, 3159 Phenylalanine ammonia-lyase Phosphatase Rapid transient induction of phenylalanine ammonia-lyase mRNA in Differential regulation of bovine brain calmodulin-dependent cyclic elicitor-treated bean cells, 6731 nucleotide phosphodiesterase isozymes by cyclic AMP-dependent Phenylalanine hydroxylase gene protein kinase and calmodulin-dependent phosphatase, 2603 Regional mapping of the phenylalanine hydroxylase gene and the Stoichiometric methylation of calcineurin by protein carboxyl phenylketonuria locus in the human genome, 6221 O-methyltransferase and its effects on calmodulin-stimulated phosphatase activity, 5612 Phenyliminodmidazolidine Characterization of octopamine-sensitive adenylate cyclase: Elucidation Phosphate, 2',3'-cyclc of a class of potent and selective octopamine-2 receptor agonists with Cyclization of RNA 3'-terminal phosphate by cyclase from HeLa cells toxic effects in insects, 599 proceeds via formation of N(3')pp(5')A activated intermediate, 1316 Phenylketonuria Phosphate metabolism Regional mapping of the phenylalanine hydroxylase gene and the Noninvasive detection and monitoring of regional myocardial ischemia in phenylketonuria locus in the human genome, 6221 situ using depth-resolved 31P NMR spectroscopy, 8747 Pheromone Phosphatldyglycerol Synthetic pheromones that promote inter-male aggression in mice, 2059 Genetic manipulation of membrane phospholipid composition in Induction of surface exclusion (entry exclusion) by Streptococcus Escherichia coli: pgsA mutants defective in phosphatidylglycerol faecalis sex pheromones: Use of monoclonal antibodies to identify an synthesis, 7530 inducible surface antigen involved in the exclusion process, 8582 Phosphatldyichoine Pheromone-degrading enzyme Interferon stimulates cholesterol and phosphatidylcholine synthesis but Kinetic properties of a sex pheromone-degrading enzyme: The sensillar inhibits cholesterol ester synthesis in HeLa-S3 cells, 2417 esterase of Antheraea polyphemus, 8827 Phosphatidylcholine produced in rat synaptosomes by N-methylation is Phloridzin enriched in polyunsaturated fatty acids, 4828 Correction of hyperglycemia with phloridzin restores the glucagon Sterol control of the phosphatidylethanolaminephosphatidylcholine response to glucose in insulin-deficient dogs: Implications for human conversion in the yeast mutant GL7, 5715 diabetes, 1544 Phophasdylethanolamine PHM-27 peptlde Evidence for conduction of protons along the interface between water Coding sequences for vasoactive intestinal peptide and PHM-27 peptide and a polar lipid monolayer, 3217 are located on two adjacent exons in the human 3548 Sterol control of the phosphatidylethanolamine-phosphatidylcholine genome, conversion in the yeast mutant GL7, 5715 phoA promoter On the correlation between HI, phase and the contact-induced Synthesis and secretion of human epidermal growth factor by Escherichia destabilization of phosphatidylethanolamine-containing coli, 7212 membranes, 5742 Genetic manipulation of membrane phospholipid composition in Phorbol 12,13-dbutyrate Escherichia coli: pgsA mutants defective in phosphatidylglycerol Activators of protein kinase C down-regulate and phosphorylate the synthesis, 7530 T3/T-cell antigen receptor complex of human T lymphocytes, 8158 Phouphatidylethaaomne N-methy"ltransferase Phorbol ester Phosphatidylcholine produced in rat synaptosomes by N-methylation is Phorbol ester effects on neurotransmission: Interaction with enriched in polyunsaturated fatty acids, 4828 neurotransmitters and calcium in smooth muscle, 604 Diacylglycerols mimic phorbol diester induction of leukemic cell Phosp Htloitol differentiation, 815 Lithium induces corticotropin secretion and desensitization in cultured Characterization of the activation of Na+/H+ exchange in lymphocytes anterior pituitary cells, 1286 by phorbol esters: Change in cytoplasmic pH dependence of the Evidence from two transformed cell lines that the phosphorylations of antiport, 1429 peptide tyrosine and phosphatidylinositol are catalyzed by different Role of protein kinase C in diacylglycerol-mediated induction of ornithine proteins, 3993 decarboxylase and reduction of epidermal growth factor binding, 1941 Inositol cyclic phosphates are produced by cleavage of Tumor-promoting phorbol diesters cause the phosphorylation of phosphatidylphosphoinositols (polyphosphoinositides) with purified epidermal growth factor receptors in normal human fibroblasts at sheep seminal vesicle phospholipase C enzymes, 4013 threonine-654, 1974 Ionic responses rapidly elicited by activation of protein kinase C in Phosphatddylinouitol 4,5-bsphosphate quiescent Swiss 3T3 cells, 2384 Phorbol myristate acetate inhibits thrombin-stimulated Ca24 mobilization Protein kinase C regulates ionic conductance in hippocampal pyramidal and phosphatidylinositol 4,5-bisphosphate hydrolysis in human neurons: Electrophysiological effects of phorbol esters, 2538 platelets, 3859 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8917

Phosphatidylserine Phosphorus metabolim Isolation of a somatic-cell mutant defective in phosphatidylserine Combinng solid-state and solution-state 31P NMR to study in vivo biosynthesis, 1926 phosphorus metabolism, 391 Characterization of pituitary calcium-activated, phospholipid-dependent Control of oxidative metabolism and oxygen delivery in human skeletal protein kinase: Redistribution by gonadotropin-releasing hormone, 8203 muscle: A steady-state analysis of the work/energy cost transfer function, 8384 Phosphoenopyruvate carboxykinase gene Sequential changes in DNA methylation patterns of the rat Phosphorylation phosphoenolpyruvate carboxykinase gene during development, 267 Phosphorylation of ribosomal protein S6 on serine after microinjection of the Abelson murine leukemia virus tyrosine-specific protein kinase into Phospboenolpyruvate carboxykdnse (GTP) Xenopus oocytes, 272 1Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in Phosphorylation enzymes of the propionic acid bacteria and the roles of vivo, 4346 ATP, inorganic pyrophosphate, and polyphosphates, 312 Phosphofrutokinase Phosphorylation of lens fiber cell membrane proteins, 653 Inhibition by 2,5-anhydromannitol of glycolysis in isolated rat Phosphorylation of DNA topoisomerase II by casein kinase II: hepatocytes and in Ehrlich ascites cells, 78 Modulation of eukaryotic topoisomerase II activity in vitro, 3164 Evidence from two transformed cell lines that the phosphorylations of Phosphofructpklnase deficiency peptide tyrosine and phosphatidylinositol are catalyzed by different Characterization of the enzymatic lesion in inherited phosphofructokinase proteins, 3993 'deficiency in the dog: An animal analogue of human glycogen storage Identification of an inhibitory region of the heat-stable protein inhibitor of disease type VII, 8109 the cAMP-dependent protein kinase, 4379 Mechanism of insulin action on membrane protein recycling: A selective 6-Phosphogluconolactonase deficiency decrease in the phosphorylation state of insulin-like growth factor II 6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme receptors in the cell surface membrane, 7314 deficiency: Possible interaction with glucose--phosphate A unique structure at the carboxyl terminus of the largest subunit of dehydrogenase deficiency, 3876 eukaryotic RNA polymerase II, 7934 Phosphoglucose isomerase Phosphorylatlon, cyclic AMP-dependent Mutations in the phosphoglucose isomerase gene can lead to marked of bovine lens 4712 alterations in cellular ATP levels in cultured fibroblasts exposed to cAMP-dependent phosphorylation a-crystallin, simple nutrient shifts, 2761 Phosphorylation, neurofilament Phosphoglycerate kinase gene Aberrant neurofilament phosphorylation in Alzheimer disease, 4274 Structure of the human phosphoglycerate kinase gene and the Phosphorylation, oxidative intron-mediated evolution and dispersal of the nucleotide-binding Purified hydrophobic proteins, chargerins, are essential for energy domain, 6965 transduction in oxidative phosphorylation, 1331 0'-Phosphohydroxylysine Studies on the mechanism of oxidative phosphorylation: Effects of Phosphorylation of hydroxylysine residues in collagen synthesized by specific FO modifiers on ligand-induced conformation changes of cultured aortic smooth muscle cells, 3091 F1, 7550 Phosholipse A2 Inhibition of human platelet phospholipase A2 activity by unsaturated iated with the murine T-cell antigen receptor is fatty acids, 371 phosphorylated in response to activation by antigen or concanavalin Inhibitors of the cytochrome P4S0 enzymes block the A, 1969 secretagogue-induced release of corticotropin in mouse pituitary tumor Tumor-promoting phorbol diesters cause the phosphorylation of cells, 1012 epidermal growth factor receptors in normal human fibroblasts at Essential role of phospholipase A2 activity in endothelial cell-induced threonine-654, 1974 modification of low density lipoprotein, 3000 Phosphorylation of hydroxylysine residues in collagen synthesized by cultured aortic smooth muscle cells, 3091 Phospholipe C Hemin inhibits internalization of transferrin by reticulocytes and Pertussis toxin inhibits chemotactic peptide-stimulated generation of promotes phosphorylation of the membrane transferrin receptor, 5170 inositol phosphates and lysosomal enzyme secretion in human Phosphorylation of the yeast equivalent of ribosomal protein S6 is not leukemic (HL-60) cells, 3277 essential for growth, 7515 Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified Phosphoserine sheep seminal vesicle phospholipase C enzymes, 4013 Phosphorylation of DNA topoisomerase II by casein kinase II: Modulation of eukarydtic topoisomerase II activity in vitro, 3164 Phospholiid3Combining solid-state and solution-state 31P NMR to study in vivo Phosphotransferase system phosphorus metabolism, 391 Reconstitution of regulatory properties of adenylate cyclase in Abnormal polyunsaturated fatty acid patterns of serum lipids in Escherichia coli extracts, 8300 alcoholism and cirrhosis: Arachidonic acid deficiency in cirrhosis, 1815 Isolation of a somatic-cell mutant defective in phosphatidylserine Phosphotyrosine biosynthesis, 1926 Purification of the platelet-derived growth factor receptor by using an Mechanism of activation of the heme-stabilized translational inhibitor of anti-phosphotyrosine antibody, 2684 reticulocyte lysates by calcium ions and phospholipid, 3119 Phosphotyrosine-containing proteins are concentrated in focal adhesions Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by and intercellular junctions in normal cells, 6576 Escherichia coli-synthesized Ha-ras encoded p21, 8310 Photius pyrals Phospomannosyl receptor Cloning of firefly luciferase cDNA and the expression of active luciferase Properties of the Syrian hamster phosphomannosyl receptor: An in Escherichia coli, 7870 aggregate of low molecular weight proteins, 8379 Photoalnty labelig N(Phosphonacetyl)-L-aspartate Identification of an active site peptide of skeletal myosin after Structure at a 2.9-A resolution of aspartate carbamoyltransferase photoaffinity labeling with N-(4-azido-2-nitrophenyl)-2-aminoethyl complexed with the bisubstrate analogue N-(phospho- diphosphate, 1575 nacetyl)-L-aspartate, 1643 PhotobacterinM kiognath Phosphoprotein kinase The presence of a copper/zinc superoxide dismutase in the bacterium Evidence that a 90-kDa phosphoprotein, an associated kinase, and a Photobacterium leiognathi: A likely case of gene transfer from specific phosphatase are involved in the regulation of Cloudman to 149 melanoma cell proliferation by insulin, 1007 eukaryotes prokaryotes, Phosphoprotein phosphatase Photobacterinum phosphorewm Evidence that a 90kDa phosphoprotein, an associated kinase, and a Acyl-acyl carrier protein as a source of fatty acids for bacterial specific phosphatase are involved in the regulation of Cloudman bioluminescence, 6085 melanoma cell proliferation by insulin, 1007 Photochemcal cyce Inhibition of the Mg(II)ATP-dependent phosphoprotein phosphatase by 4115 the regulatory subunit of cAMP-dependent protein kinase, 7565 Unidirectional circulation in a prebiotic photochemical cycle, Phosphorlbosylamlnolmldazlecarboxamlde transformylae Eubacteria, halobacteria, and the origin of photosynthesis: The Inhibition of phosphorbosylaminoimidazolecarboxamide transformylase photocytes, 3716 by methotrexate and dihydrofolic acid polyglutamates, 4881 Eubacteria, halobacteria, and the origin of photosynthesis: The Phosphoribosyltransferase photocytes (Correction), 7154 Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: Presence of a coding region common Photodissoclaton to animal and bacterial phosphoribosyltransferases that has a variable Molecular dynamics simulation of photodissociation of carbon monoxide intron/exon arrangement, 2731 from hemoglobin, 2034 Phosphorus-31 NMR Combining solid-state and solution-state 31P NMR to study in vivo The primary process of vision and the structure of bathorhodopsin: A phosphorus metabolism, 391 mechanism for photoisomerization of polyenes, 259 8918 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Photoperiodism Pigment-dispersing hormone Neurochemical basis for the photic control of circadian rhythms and Characterization of a pigment-dispersing hormone in eyestalks of the seasonal reproductive cycles: Role for acetylcholine, 4277 fiddler crab Uca pugilator, 5319 Photophosphorylation Pln Evidence that the Mg-dependent low-affinity binding site for ATP and Pi Antibodies to peptides corresponding to a conserved sequence of demonstrated on the isolated fl subunit of the FoF1 ATP synthase is a gonococcal pilins block bacterial adhesion, 915 catalytic site, 1886 P1us Photoreactivation Adhesion to human cells by Escherichia coli lacking the major subunit of Photoreactivation of UV-induced pyrimidine dimers and erythema in the a digalactoside-specific pilus-adhesin, 1800 marsupial Monodelphis domestica, 2409 Pimozide Photoreceptor Neuroleptic drugs attenuate calcium influx and tension development in Statistical test of linearity of photoreceptor transduction process: Limulus rabbit thoracic aorta: Effects of pimozide, penfluridol, chlorpromazine, passes, others fail, 232 Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to and haloperidol, 1237 kainate, 1837 Pindolol Photorespiration (-)-S-[3H]CGP-12177 and its use to determine the rate constants of Structure of glycolate oxidase from spinach, 6855 unlabeled P-adrenergic antagonists, 925 Photosporulation Piper futokaisura Modified cryptochrome in vivo absorption in dim photosporulation Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): Specific inhibition of in mutants of Trichoderma, 2736 vitro and in vivo platelet-activating factor-induced effects, 672 Photosynthesis Eubacteria, halobacteria, and the origin of photosynthesis: The Pisum sativum photocytes, 3716 Inheritance, organization, and mapping of rbcS and cab multigene Molecular mechanism of water oxidation in photosynthesis based on the families in pea, 5083 functioning of manganese in two different environments, 6119 Gene expression of pigment-binding proteins of the bacterial Pituitary photosynthetic apparatus: Transcription and assembly in the membrane Calcitonin gene-related peptide and its binding sites in the human central of Rhodopseudomonas capsulata, 6485 nervous system and pituitary, 248 Effect of magnetic fields on the triplet state lifetime in photosynthetic A nonmitogenic pituitary function of fibroblast growth factor: Regulation reaction centers: Evidence for thermal repopulation of the initial of thyrotropin and prolactin secretion, 5545 radical pair, 6850 Isolation and partial characterization of a pair of prolactins released in Excited states and primary photochemical reactions in the photosynthetic vitro by the pituitary of a cichlid fish, Oreochromis mossambicus, 7490 bacterium Heliobacterium chlorum, 6865 Eubacteria, halobacteria, and the origin of photosynthesis: The Pituitary cell photocytes (Correction), 7154 Calcium currents in GH3 cultured pituitary cells under whole-cell Subunit stoichiometry and juxtaposition of the photosynthetic coupling voltage-clamp: Inhibition by voltage-dependent potassium factor 1: Immunoelectron microscopy using monoclonal currents, 1108 antibodies, 7874 Lithium induces corticotropin secretion and desensitization in cultured Regulation of ribulose bisphosphate carboxylase activity in vivo by a anterior pituitary cells, 1286 light-modulated inhibitor of catalysis, 8024 Leukotriene C4 as a mediator of luteinizing hormone release from rat Analysis of optical spectra from single crystals of Rhodopseudomonas anterior pituitary cells, 3834 viridis reaction centers, 8463 Pituitary hormone secretion Photosystem II Effects of intravenous and intraventricular injection of antisera directed Organization of pigment proteins in the photosystem II complex of the against corticotropin-releasing factor on the secretion of anterior cyanobacterium Anacystis nidulans R2, 6903 pituitary hormones, 7787 Phototoxdcity Pituitary tumor A possible mechanism of psoralen phototoxicity not involving direct Inhibition of growth of a prolactin and growth hormone-secreting interaction with DNA, 6158 pituitary tumor in rats by D-tryptophan-6 analog of luteinizing hormone-releasing hormone, 1252 Phototransduction Amino acid sequence of the a subunit of transducin deduced from the pK cDNA sequence, 4311 Modification of pK values caused by change in H-bond geometry, 2741 Light-activated guanosinetriphosphatase in Musca eye membranes resembles the prolonged depolarizing afterpotential in photoreceptor Placenta cells, 7116 Incomplete X chromosome dosage compensation in chorionic villi of human placenta, 3390 Phycobiliprotein Insulin-related genes expressed in human placenta from normal and Molecular cloning and nucleotide sequence of the a and , subunits of diabetic pregnancies, 3868 allophycocyanin from the cyanelle genome of Cyanophora Identification of proliferin mRNA and protein in mouse placenta, 4356 paradoxa, 3242 Human placental alkaline phosphatase in liver and intestine, 6080 Phylogeny Planetary nebula Evolution of green plants as deduced from SS rRNA sequences, 820 Spectrum and chemical composition of the remarkable planetary nebula Pattern analysis of 5S rRNA, 2437 NGC 6537, 2202 Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses, 6955 Plant evolution Evolution of green plants as deduced from 5S rRNA sequences, 820 Physarum polycephalum Cloning of Physarum actin sequences in an exonuclease-deficient Plant gene bacterial host, 2698 Expression of phaseolin cDNA genes in yeast under control of natural Replication timing of the H4 histone genes in Physarum plant DNA sequences, 334 polycephalum, 6475 Plant pathogen Phytoalexin Cloning determinants of pathogenesis from Pseudomonas syringae Rapid transient induction of phenylalanine ammonia-lyase mRNA in pathovar syringae, 406 elicitor-treated bean cells, 6731 Plaque, neuritic Phytochrome Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are Mode of coaction between blue/UV light and light absorbed by antigenically related, 8729 phytochrome in light-mediated anthocyanin formation in the milo (Sorghum vulgare Pers.) seedling, 6124 Plasma membrane Isolation and partial characterization of a fatty acid binding protein in rat Phytohemagglutinin liver plasma membranes, 4 Expression of cell-cycle-dependent genes in phytohemagglutinin- Calcium channel antagonists inhibit the acrosome reaction and bind to stimulated human lymphocytes, 5375 plasma membranes of sea urchin sperm, 1460 Phytotoxin Selective internalization of granule membrane after secretion in mast Bipolaroxin, a selective phytotoxin produced by Bipolaris cells, 1711 cynodontis, 8291 Piasmacytoma ir electron Gene localization on sorted chromosomes: Definitive evidence on the Topology of bonding in if-electron systems, 1 relative positioning of genes participating in the mouse plasmacytoma-associated typical translocation, 6975 Picornavirus Sequence analysis of hepatitis A virus cDNA coding for capsid proteins Plasmid and RNA polymerase, 2143 Genes specifying degradation of 3-chlorobenzoic acid in plasmids pAC27 Primary structure and gene organization of human hepatitis A virus, 2627 and pJP4, 1638 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985) 8919

Plasmid DNA Platelet-activating factor Plasmid-induced "hit-and-run" tumorigenesis in Chinese hamster embryo Characterization of a platelet-activating factor receptor antagonist fibroblast (CHEF) cells, 2839 isolated from haifenteng (Piperfutokadsura): Specific inhibition of in vitro and in vivo platelet-activating factor-induced effects, 672 Plasmid pBR322 Site-specific cleavage of left-handed DNA in pBR322 by Platelet aggregation A-tris(diphenylphenanthroline)cobalt(III), 6460 A monoclonal antibody against human thrombospondin inhibits platelet aggregation, 3472 Plasmid pT181 Inhibition of platelet aggregation by a monoclonal antibr by against Plasmid pT181 replication is regulated by two countertranscripts, 638 human fibronectin, 3844 Plasmid RK2 Platelet-derived growth factor korA function of promiscuous plasmid RK2: An autorepressor that Platelet-derived growth factor agonist activity of a secreted form of the inhibits expression of host-lethal gene kilA gene and replication gene v-sis oncogene product, 1721 trfA, 7374 Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture, 2404 Plasmid R6K Purification of the platelet-derived growth factor receptor by using an Mutations in direct repeat sequences and in a conserved sequence anti-phosphotyrosine antibody, 2684 adjacent to the repeats result in a defective replication origin in Platelet-derived growth factor mimics phorbol diester action on epidermal plasmid R6K, 1480 growth factor receptor phosphorylation at threonine-654, 4080 Replication initiator protein of plasmid R6K autoregulates its own Stimulation of in vitro human skin collagenase expression by synthesis at the transcriptional step, 2574 platelet-derived growth factor, 4132 Plasmid RSF1010 Arterial smooth muscle cells in primary culture produce a Protein RepC is involved in copy number control of the broad host range platelet-derived growth factor-like protein, 4418 In vitro mutagenesis of the v-sis transforming gene defines functional plasmid RSF1010, 6090 domains of its growth factor-related product, 5295 Plasmid transduction Inhibitory effects of-interferon on the expression of genes regulated by A defective phage system reveals bacteriophage T4 replication origins platelet-derived growth factor, 7608 that coincide with recombination hot spots, 3345 The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor, 7845 Plasmin, seminal The structure of caltrin, the calcium-transport inhibitor of bovine seminal Platelet membrane plasma, 6490 Synthesis of analogs of human platelet membrane glycoprotein IIb-IIIa complex by chicken peripheral blood thrombocytes, 7319 Plasminogen activator Production of plasminogen activator in cultures of superior cervical Ploidy ganglia and isolated Schwann cells, 3519 Invasiveness and ploidy of human mammary carcinomas in short-term Coronary thrombolysis with facilitated absorption of intramuscularly culture, 1805 injected tissue-type plasminogen activator, 4258 Human urokinase gene is located on the long arm of chromosome Plumbago zeylanica 10, 4448 Preferential fertilization in Plumbago: Ultrastructural evidence for Differentiation-enhanced binding of the amino-terminal fragment of gamete-level recognition in an angiosperm, 6129 human urokinase plasminogen activator to a specific receptor on U937 monocytes, 4939 Podocyte Basement membrane heparan sulfate proteoglycans are concentrated in Plasminogen activator inhibitor the laminae rarae and in podocytes of the rat renal glomerulus, 32% Activated protein C stimulates the fibrinolytic activity of cultured Localization of sialic acid in kidney glomeruli: Regionalization in the endothelial cells and decreases antiactivator activity, 1121 podocyte plasma membrane and loss in experimental nephrosis, 8508 The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related, 8710 pol gene Expression of enzymatically active reverse transcriptase in Escherichia Plasmodium chabaudi coli, 4944 Enhanced mosquito blood-finding success on parasitemic hosts: Evidence Presence of retrovirus reverse transcriptase-related gene sequences in for vector-parasite mutualism, 7725 avian cells lacking endogenous avian leukosis viruses, 5097 Pknodinfalfparum Poliovylpis Interspersed blocks of repetitive and charged amino acids in a dominant Synthetic peptides from four separate regions of the poliovirus type 1 immunogen of Plasmodium falciparum, 543 capsid protein VP1 induce neutralizing antibodies, 910 Expression of Plasmodium falciparum surface antigens in Escherichia Poliovirus protease does not mediate cleavage of the 220,000-Da coli, 2518 component of the cap binding protein complex, 2723 Susceptibility of human malaria parasites to chloroquine is pH In vitro synthesis of infectious poliovirus RNA, 8424 dependent, 2784 Synthesis of small nuclear ribonucleoprotein particles by the malarial Politics parasite Plasmodiumfalciparum, 3635 Outlining social physics for modern societies-locating culture, Membrane knobs are required for the microcirculatory obstruction economics, and politics: The Enlightenment reconsidered, 5582 induced by Plasmodium falciparum-infected erythrocytes, 3829 A blood stage antigen of Plasmodium falciparum shares determinants Pollination with the sporozoite coat protein, 5121 Flower petal microtexture is a tactile cue for bees, 4750 Monkey-denved monoclonal antibodies against Plasmodium Poly(A) falciparum, 6272 A unique subspecies of histone H4 mRNA from rat myoblasts contains Plasnodium vinckei poly(A), 6760 Oxidative stress and protective mechanisms in erythrocytes in relation to Poly(A)-bindin protein Plasomodium vinckei load, 548 Heat shock increases the synthesis of the poly(A)-binding protein in Plastome HeLa cells, 6884 Efficient induction and selection of chloroplast-encoded mutants in 1485 Polyadenylylation antibiotic-resistant Nicotiana, Polyadenylylation of sea urchin histone RNA sequences in transfected Platelet COS cells, 1094 Inhibition of human platelet phospholipase A2 activity by unsaturated Role of an RNA cleavage/poly(A) addition site in the production of fatty acids, 371 membrane-bound and secreted IgM mRNA, 8658 Calmodulin accelerates the rate of polymerization of human platelet actin Poly(ADP-ribose) snhetase and alters the structural characteristics of actin filaments, 1683 Accumulation of DNA intermediates in cells Lysosomotropic agents selectively potentiate thrombin-induced acid 1O-kilobase replication hydrolase secretion from platelets, 2374 treated with 3-aminobenzamide, 104 Platelet-derived collagenase inhibitor: Characterization and subcellular Polyamine biosynthesis localization, 2779 Nucleotide sequence of murine ornithine decarboxylase mRNA, 1673 Phorbol myristate acetate inhibits thrombin-stimulated Ca2W mobilization Prevention of a plant disease by specific inhibition of fungal polyamine and phosphatidylinositol 4,5-bisphosphate hydrolysis in human 6874 platelets, 3859 biosynthesis, In vitro correction of the abnormal multimeric structure of von Poly(dA-dT) Willebrand factor in type Ha von Willebrand's disease, 5968 Naturally occurring poly(dA-dT) sequences are upstream promoter Interaction of purified type IIB von Willebrand factor with the platelet elements for constitutive transcription in yeast, 8419 membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein Ub/Illa complex and initiates aggregation, 7424 Poly(dC-dG)-pol(dC-dG) Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding Ethylation of poly(dC-dG)poly(dC-dG) by ethyl methanesulfonate site from human platelets, 7434 stimulates the activity of mammalian DNA methyltransferase in The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von vitro, 1045 Willebrand factor binding to platelets, 8057 The primary plasminogen-activator inhibitors in endothelial cells, Poly[d(G-C)] platelets, serum, and plasma are immunologically related, 8710 Unusual proton exchange properties of Z-form poly[d(G-C)], 1594 8920 Subject Index Proc. Natl. Acad. Sci. USA 82 (1985)

Polyene Postsyaptic deniy The primary process of vision and the structure of bathorhodopsin: A The postsynaptic density: A possible role in long-lasting effects in the mechanism for photoisomerization of polyenes, 259 central nervous system, 3494 A neutron diffraction study on the location of the polyene chain of retinal Evidence that receptors mediating central synaptic potentials extend in bacteriorhodopsin, 3227 beyond the postsynaptic density, 3504 Polygenic segregation Posture training Detection of simple polygenic segregations in a natural population, 8552 Behavioral method for the treatment of idiopathic scoliosis, 2493 Poly(GluAlamTyrl@) Potassium Gene repertoire of the anti-poly(Glu6wAla"TWyrie) (GAT) immune Correlation of ouabain-sensitive ion movements with cell-cycle response: Comparison of VH, V,, and D regions used by anti-GAT activation, 1599 antibodies and monoclonal antibodies produced after anti-idiotypic Adenosine-activated potassium conductance in cultured striatal immunization, 4788 neurons, 4857 Poly(Glu"Ala-Tyr') Potassium-39 (Glu 62,Ala3O,Tyr5),, serves as high-affinity substrate for tyrosylprotein 23Na and 39K NMR studies of ion transport in human erythrocytes, 1099 sulfotransferase: A Golgi enzyme, 6143 Potassium-40 Polyhedrosis virus Biological effects of background radiation: Mutagenicity of 'OK, 8602 human interleukin 2 in insect Modification and secretion of produced Potassium channel cells by a baculovirus expression vector, 8404 Voltage-dependent sodium and potassium channels in mammalian Polymorphism cultured Schwann cells, 948 Allelic polymorphism and transassociation of molecules encoded by the The all-or-none role of innervation in expression of apamin receptor and HLA-DQ subregion, 1776 of apamin-sensitive Ca24-activated K+ channel in mammalian skeletal Chloroplast DNA diversity is low in a wild plant, Lupinus texensis, 6950 muscle, 2188 Dual modulation of K channels by thyrotropin-releasing hormone in Polynesia clonal pituitary cells, 4282 Bird remains from an archaeological site on Henderson Island, South Intracellular calcium regulates basolateral potassium channels in a Pacific: Man-caused extinctions on an "uninhabited" island, 6191 chloride-secreting epithelium, 8823 Polyneuropathy Potassium conductance Capillary number and percentage closed in human diabetic sural At and K opioids inhibit transmitter release by different mechanisms, 1860 nerve, 2513 Protein kinase C regulates ionic conductance in hippocampal pyramidal Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently neurons: Electrophysiological effects of phorbol esters, 2538 antigens for IgM paraproteins, 6697 Potassium curet Polynudeotide phosphorylase Calcium currents in GH3 cultured pituitary cells under whole-cell Purification and characterization of polynucleotide phosphorylase from voltage-clamp: Inhibition by voltage-dependent potassium cucumber, 1311 currents, 1108 GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal Polyoma virus cells in hippocampal cultures, 1558 An adenovirus vector system used to express polyoma virus tumor Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion antigens, 1359 cells, 3040 Tyrosine phosphorylation within the amino-terminal domain of pp60c-sm Acetylcholine and phorbol esters inhibit potassium currents evoked by molecules associated with polyoma virus middle-sized tumor adenosine and cAMP in Xenopus oocytes, 6001 antigen, 4568 Ionic currents that generate the spontaneous diastolic depolarization in Complexes of polyoma virus medium T antigen and cellular individual cardiac pacemaker cells, 7796 proteins, 7952 Potato spindle tuber virold Polypeptide folding Ultraviolet light-induced crosslinking reveals a unique region of local Is there a single pathway for the folding of a polypeptide chain?, 4028 tertiary structure in potato spindle tuber viroid and HeLa 5S RNA, 6590 Polyphosphate Phosphorylation enzymes of the propionic acid bacteria and the roles of Potyvirus ATP, inorganic pyrophosphate, and polyphosphates, 312 Sequence determination of the capsid protein gene and flanking regions of tobacco etch virus: Evidence for synthesis and processing of a Polyprotein polyprotein in potyvirus-genome expression, 3969 Primary structure and gene organization of human hepatitis A virus, 2627 Sequence determination of the capsid protein gene and flanking regions pp60gw protein of tobacco etch virus: Evidence for synthesis and processing of a Tyrosine phosphorylation within the amino-terminal domain of pp60-src polyprotein in potyvirus genome expression, 3969 molecules associated with polyoma virus middle-sized tumor antigen, 4568 Polysaccharide Exopolysaccharide-deficient mutants of Rhizobium meliloti that form pp6O'v-m ineffective nodules, 6231 Partial purification and characterization of a pp60v1srC-related tyrosine kinase from bovine brain, 6025 Polysaccharlde capsule NZB mouse system for production of monoclonal antibodies to weak Prazosin bacterial antigens: Isolation of an IgG antibody to the polysaccharide Prazosin, an ai-adrenergic receptor antagonist, suppresses experimental capsules of Escherichia coli K1 and group B meningococci, 1194 autoimmune encephalomyelitis in the Lewis rat, 5915 Polysome Pre-B-lymphocyte Mobilization of specific maternal RNA species into polysomes after Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell fertilization in Xenopus laevis, 7636 line, 479 Population, natural pre-S region Detection of simple polygenic segregations in a natural population, 8552 A frameshift mutation of the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates Porcine follicular fluid binding to polymerized albumin, 3440 Hypoxanthine is the principal inhibitor of murine oocyte maturation in a Prealbumin low molecular weight fraction of porcine follicular fluid, 454 Plasma and cellular retinoid-binding proteins and transthyretin Porphyrin (prealbumin) are all localized in the islets of Langerhans in the Stabilization of higher-valent states of iron porphyrin by hydroxide and rat, 2488 methoxide ligands: Electrochemical generation of iron(IV)-oxo Precambrian porphyrins, 4301 Pellet microfossils: Possible evidence for metazoan life in Early Positron emission tomography Proterozoic time, 5809 Muscarinic cholinergic receptor in the human heart evidenced under Precursor sequence physiological conditions by positron emission tomography, 584 and of a cDNA Substituted benzamides as ligands for visualization of dopamine receptor Cloning sequence analysis encoding porcine binding in the human brain by positron emission tomography, 3863 mitochondrial aspartate aminotransferase precursor, 6065 Functional mapping of the human cerebellum with positron emission Predation tomography, 7462 Persistence and coexistence of a nonsymbiotic coral in open reef Post-transcriptional regulation environments, 2432 Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is Pregnancy controlled by sequences in the 3'-terminal part of the gene, 4389 Unusual apparently constitutive interferons and antagonists in human placental blood, 5010 Post-transtional modification A first exon-encoded domain of ElA sufficient for posttranslational Prehitiation complex modification, nuclear-localization, and induction of adenovirus E3 Ribosomal RNA transcription: Proteins and DNA sequences involved in promoter expression in Xenopus oocytes, 8434 preinitiation complex formation, 1668