Contact Elisa Corteggiani Carpinelli Website: elisacorteggiani.com Citizenship: Italian ▪ Date of birth: 04 March 1982 e-mail: [email protected]

Key Skills Enthusiastic scientist with great capability for design and management of scientific projects. Proficient or familiar with a vast array of laboratory techniques and with the fundamental data analysis tools. Skilled at scientific communication and teaching. Experienced in working in teams and in projects where a multidisciplinary approach is required.

Education 2007 to 2011 PhD in Biochemistry and Biotechnology (grade: A) University of Padua, Italy 2004 to 2006 Master Degree in Molecular Biology (110/110 with distinction) University of Padua, Italy 2001 to 2004 Bachelor Degree in Molecular Biology (110/110 with distinction) University of Padua, Italy 1996 to 2001 High school diploma (100/100) Liceo Classico F.A.Gualterio, Orvieto, Italy

Most relevant Post-graduate Schools, attended as student and/or as teacher Teacher 2013 XVII International School of Pure and Applied Biophysics (Venice) Renewable energy and biofuels: a biophysical and biochemical approach Student 2009 School on Next generation sequencing: available technologies and applications (Padova) Organized by the graduate school on Biochemistry and Biotechnology, teacher: Prof. Giorgio Valle Student 2009 School on Proteomics and Mass Spectrometry: a theoretical and practical course (Padova) Organized by the graduate school on Biochemistry and Biophysics, teacher: Prof. Peter James Student 2007 XI International School of Pure and Applied Biophysics (Venice) Advanced optical microscopy methods in biophysics

Post graduate Research University of Padua, Padua, Italy Post Doctoral Fellowship Functional Genomics Research group (PI Prof. Giorgio Valle) May 2011 to May 2013 Topics: functional genomics and mutagenesis of the microalgae Nannochloropsis gaditana metagenomic analysis of water samples from an highly polluted area Responsibilities: identification of scientific problems; design and realization of experiments; collaboration to various research projects of the group; realization of web facilities; education of undergraduate and master’s students

University of Padua, Padua, Italy PhD program Functional Genomics Research group (PI Prof. Giorgio Valle) January 2009 to April 2011 Topic: genomics and transcriptomics of the microalgae Nannochloropsis gaditana Responsibilities: identification of a scientific problem of interest and elaboration of a scientific project; design of the experimental strategies to tackle the chosen scientific problem; realization of some of the experiments; coordination of the work of the other researchers involved in the project; setting up of innovative laboratory procedures; education of undergraduate and master’s students

University of Padua, Padua, Italy PhD program Photosynthesis Research group (PI Prof. Giorgio Mario Giacometti) January 2007 to December 2008 Topics: functional and regulatory aspects of the photosynthetic apparatus of high plants and cyanobacteria peroxidase activities in the photosynthetic compartments Responsibilities: design of the experimental strategies to tackle the assigned scientific problems; realization of the experiments; setting up of new laboratory procedures; troubleshooting; education of undergraduate and master students

Employments not in Academia Various Private and Public Companies Short term contracts as Teacher Specialization courses about renewable energies for employees December 2013 to now

Various elementary and high schools Short term contracts as Teacher Laboratories experiences for school children and refresh course for life 2007 to 2012 science’s teachers

Teaching Experience in Academia University of Padua, Padua, Italy Teaching Assistant Laboratories of Molecular Biology Academic years 2006-2007; 2007-2008; 2010-2011 Program: production of a library of Lambda Phage DNA; Plasmid DNA preparation from E.coli; genomic DNA extraction from human saliva; PCR amplification; agarose and polyacrylamide gel electrophoresis.

University of Padua, Padua, Italy Teaching Assistant Laboratories of Structural Biochemistry Academic years 2008-2009; 2009-2010; 2011-2012 Program: growth and induction of E.coli strains transformed for the overexpression of a pH sensitive YFP; purification of the YFP by affinity chromatography; spectroscopic and electrophoretic analysis of the obtained fractions, fluorometric analysis of the purified proteins at different pH.

University of Padua, Padua, Italy Teaching Assistant Laboratories of Metabolic Biochemistry Academic year 2011-2012 Program: measure of the photosynthetic activity of leaf disks in a simple experimental system in response to different lights; purification of mitochondria from yeast and measure of the ATP production of the purified mitochondria using a fluorometric assay.

University of Padua, Padua, Italy Teaching Assistant Laboratories of Biochemistry Academic year 2012-2013 Program: introduction to absorbance spectroscopy, measure of the enzymatic kinetics of l-lactate dehydrogenase, mathematical formalisation of the data.

University of Padua, Padua, Italy Teaching Assistant Tutorials and Exercises of Metabolic Biochemistry Academic years 2009-2010; 2010-2011; 2011-2012 Program: principles of bioenergetics; glycolysis, gluconeogenesis and pentose phosphate pathway; citric acid cycle; metabolic regulation; fatty acid metabolism; amino acid metabolism; hormonal regulation of mammalian metabolism; biotechnological applications of the metabolic manipulation of various microorganisms.

University of Padua, Padua, Italy Teaching Assistant Practical Laboratories of Genomics Academic years 2010-2011; 2011-2012; 2012-2013 Programs of the three years: ! Library preparation of full-length transcripts using the In-Fusion Full Length library construction system, sequencing and bioinformatics analysis of the data; ! Introduction to PERL programming and realisation of a simple program for primer oligonucleotide design; experimental testing of the designed primers by PCR reaction and sequencing; ! Metagenomic analysis of a water sample: sampling, extraction of nucleic acids, library preparation, sequencing and data analysis

Technical skills Molecular Biology Purification of nucleic acids from various organisms (plants, algae and bacteria); design and production of recombinant constructs for genome mutagenesis and protein overexpression; transformation of bacteria, cyanobacteria yeast and algae; enzymatic manipulation of nucleic acids; agarose and polyacrylamide electrophoresis; pulsed field gel electrophoresis (PFGE). Genomics and Genomic DNA library preparation using the E.coli host system; preparation of mate-paired libraries Transcriptomics for SOLiD sequencing; preparation of libraries for Ion Proton sequencing; some experience with genome assembly; mRNA enrichment and ribodepletion of Total RNA samples; preparation of full length cDNA libraries; enzymatic manipulation of RNA for 5’ end capturing. Microscopy In vivo Fluorescent and Confocal Microscopy Biochemistry Purification of active proteins and protein complexes from photosynthetic membranes; overexpression and purification of proteins in E.coli host system; native and denaturing protein electrophoresis, 2D gel electrophoresis; western blotting and immunodecoration; fplc and hplc for proteins and pigments analysis and purification; measures of oxygen evolution from photosynthetic samples; preparation of protein samples for analysis with mass-spectrometry. Spectroscopy Absorbance spectroscopy; pulsed amplitude modulated (PAM) fluorometry for analysis of photosynthetic activity; fluorescence spectroscopy.

Language skills Italian (native language) English (speak fluently; read and French (basic knowledge) write with high proficiency) Informatics skills Basic knowledge of Perl programming, Proficient usage of spreadsheets and Proficient in the design and proficient usage of many available text editors, good capabilities with management of web pages and blogs biological databases and analysis tools digital graphic software and in the use of socials

Publications in international journals ! A deep survey of alternative splicing in grape reveals changes in the splicing machinery related to tissue, stress condition and genotype. Vitulo N, Forcato C, Corteggiani Carpinelli E, Telatin A, Campagna D, D’Angelo M, Zimbello R, Corso M, Vannozzi A, Bonghi C, Lucchin M and Valle G BMC Plant Biology. 14:99. doi:10.1186/1471-2229-14-99. Epub 2014 Apr 17.

! Chromosome scale genome assembly and transcriptome profiling of Nannochloropsis gaditana in nitrogen depletion. Corteggiani Carpinelli E, Telatin A, Vitulo N, Forcato C, D’Angelo M, Schiavon R, Vezzi A, Giacometti GM, Morosinotto T, Valle G. Mol. Plant (2014) 7 (2): 323-335. doi: 10.1093/mp/sst120. First published online: August 21, 2013

! Acclimation of Nannochloropsis gaditana to different illumination regimes: Effects on lipids accumulation. Simionato D, Sforza E, Corteggiani Carpinelli E, Bertucco A, Giacometti GM, Morosinotto T. Bioresour Technol. 2011 May;102(10):6026-32. doi: 10.1016/j.biortech.2011.02.100. Epub 2011 Mar 2.

! Going ultradeep to unravel the secret recipe of biofuel. Elisa Corteggiani Carpinelli LAP Pubblishing. 2011

Communication at Scientific Conferences in Italian Institutions XVII School of Pure and Applied Biophysics, Venice, Italy Lecture Annual International School for PhD Students January 2013 "Renewable energy and biofuels: a biophysical and biochemical approach" Topic of the talk: Introduction to genomics and transcriptomics. Case study: the genome and transcriptome of the microalgae N. gaditana: what did we leant? Presentation of Bioinformatics tools to interrogate the genomic data.

Italian National Academy “Accademia dei Lincei”, Rome, Italy Oral communication International Conference on renewable energy: November 2009 “Biological processes as a possible source for renewable energy” Topic of the talk: recent achievements on genomics and transcriptomics of the microalgae N. gaditana

Lectures and web Collaboration with the “Fenice Green Energy Park” for 2013 to now didactic laboratories for school children about biofuels and for the setting up of a photobioreactor

Realization of web pages and video-tutorials for Since 2008 and until now students and teachers (see http://elisacorteggiani.com/ section portfolio)

Cultural Association, Orvieto, Italy Communication at Public Conference Lectures for the 150 anniversary of “the origin of species” May 2009 Topic of the lecture: what Darwin didn’t know yet: evidences and elements that genetics and molecular biology added to Darwin’s theory of evolution by natural selection.

Hall of Residence for University Students “Marianum”, Padova, Italy Communication at Public Conference Lecture for the students of the residence January 2012 Topic of the lecture: Let’s talk about bioethics (the method used for the lecture and many of the contents were inspired by “Justice with Michel Sandel”, and I added specific references to some topics of Bioethics)

“F.A.Gualterio” High School, Orvieto, Italy Invited Author for the School Journal Editorials about the scientific literature and the wonder for School years 2007-2008; 2008-2009 nature, with suggested readings

Going ultra deep to unravel the secret recipe of biofuel Genomic, transcriptomic and biochemical analysis of the metabolism of the microalga Nannochloropsis gaditana in order to understand and increase its oil productivity

During the first two years of my PhD I was involved in various projects of biochemical characterization of the photosynthetic apparatus and of the proteins involved in its regulation. In this period I manifested a growing interest for some recent studies concerning the culturing of photosynthetic microorganisms to harness the energy of sunlight for powering human activities and I was therefore given the opportunity to contribute to a new project of the group concerning the production of biodiesel from microalgal biomass. I started working at the culturing of various oleaginous microalgae, measuring their physiological parameters and their growth kinetics and setting up the protocols for nucleic acid and protein extractions. Some of the results of this work are reported in (Simionato et al. 2011). The project envisioned the realization of efficient production plants where microalgae were used as factories of substrates for biofuel production. The plants would have been the result of the collaboration between biologists and engineers. The work in this interdisciplinary team and the discussions that we shared during the periodical meetings represented for me an excellent scientific experience and contributed to enlarge my vision of the biotechnological task. After attending a course for graduated students about next-generation sequencing, I had a proposal for my colleagues: I wanted to start a project of genome and transcriptome sequencing of a oleaginous microalga to pinpoint the genes responsible for the accumulation of oil inside the cell and to open up the perspective of genetic manipulation of the microorganism in order to boost its productivity. My supervisor agreed that the idea was interesting and gave me the chance to carry out the project on my own responsibility. In 2009 I started working on the sequencing of the genome and the transcriptome of the microalga Nannochloropsis gaditana in close collaboration with the group of Professor Giorgio Valle (Genomics Unit of the University of Padova) and of Doctor Tomas Morosinotto (Unity of Microalgal Biophysiology of the University of Padova). After three years work, the results of my research were: the complete! sequence of the genome of Nannochloropsis gaditana at chromosome level and the prediction and annotation of its genes (the data are deposited at the NCBI as bioproject 170989); the profile of the gene expression of Nannochloropsis gaditana in conditions of oil accumulation compared to conditions of standard growth (no oil) (the data are deposited at the NCBI as bioproject 231651); the elaboration of an interpretative model of the metabolic fluxes that lead to oil accumulation. My analyses of the genome and transcriptome of N. gaditana were accepted for publication on Molecular Plant in 2013 (Corteggiani Carpinelli et al. 2014) (pubmed id 23966634) Moreover together with my colleagues of the Functional Genomics Unit of the University of Padova I worked at the release of a web resource of Nannochloropsis genome (www.nannochloropsis.org) and we also opened a blog (www.nannochloropsis.org/blog) to promote communication and collaboration among scientist involved in this field of investigation.

Introduction to the Nannochloropsis’ metabolism discovery project Various species of microalgae had been observed to convert efficiently the solar energy into triacylglycerols, which are optimal substrates for the production of oil- based diesel fuel. Despite some promising results obtained by cultivating the microalgae in photobioreactors, none of the currently available strains appeared to

! 1! be suitable for energetically convenient industrial production. A leap in productivity could be possibly obtained from the genetic improvement of the available oleaginous strains. In this respect, Nannochloropsis represented an attractive candidate, being a native oil producer; moreover it was later shown to be transformable with exogenous DNA, and some strains seem to be also capable of homologous recombination.

When cultured in normal growth conditions with sufficient nitrogen, Nannochloropsis cells had an oil content of about 30% of their dry weight. Various culturing conditions were observed to increase the average oil content per cell, however these conditions supported only slow growth rates of the cultures and therefore the overall productivity resulted decreased. Among these conditions there was nitrogen deprivation. Overcoming the trade-off between oil accumulation and biomass production Figure 1 Schematic representation was the first possibility that had to be tested in order of Nannochloropsis single cell to improve the productivity.! Being Nannochloropis a poorly studied organism, the sequencing and annotation of the genome seemed the most rapid strategy to start delineating the metabolic pathways present in the cell and possibly involved in the accumulation of triacylglycerols. Moreover the genome sequence is a fundamental starting point for targeted genetic mutagenesis. Important information about the up-regulated and down-regulated pathways could be gained by comparing the abundance of the transcripts expressed when cells accumulated high amounts of triacylglycerol with the abundance of the transcripts expressed when cells showed only limited accumulation of triacylglycerols.

Results Gene annotation We obtained the sequence of the nuclear genome as well as of the genomes of the organelles of Nannochloropsis gaditana B-31. We assembled the 28.5 Mega bases of the nuclear genome in 58 large scaffolds, 21 of which accounted for complete chromosomes and we completely assembled the circular genomes of the organelles. We identified a total of 10646 genes and we attributed an annotation to 6311 of them. The analysis of the annotated genes using the “pathway tool” software yielded the metabolic map showed in Figure 2. The analysis of the annotated genes and pathways revealed various traits, which are relevant for the genetic manipulation of Nannochloropsis with the final goal of improving its oil productivity in a production plant: • We identified pathways leading to the synthesis of cellulose and sulphated fucans and pathways responsible for the remodelling of the cellulose. These indications casted a light on the molecular composition of the cell wall and also suggest possible targets of genetic modification. Indeed, one of the most energy consuming steps during oil extraction from Nannochloropsis is the breakage of the cell wall. Targeted genetic mutations of the genes assigned to these pathways might help weakening the cell wall and saving energy during oil extraction. • We identified a group of genes that could be attributed to a pathway of biosynthesis of chrysolaminarines, which are very common storage sugars found in various neighbouring species of microalgae. The identification of a pathway of sugar storage is of particular interest, since its expression can be

! 2! studied to better understand the metabolic fluxes of carbon and energy in Nannochloropsis in different culturing conditions.

Authors: Elisa Corteggiani Carpinelli, University of Padua Andrea Telatin, University of Padua Nicola Vitulo, University of Padua NgaditanaCyc: Nannochloropsis gaditana Cellular Overview

GLYCOLYSIS HORMONES BIOSYNTHESIS TCA CYCLE CARBOXYLATES DEGRADATION AMINO ACIDS BIOSYNTHESIS AMINO ACIDS DEGRADATION valine degradation I S-methyl- superpathway of leucine, valine, beta-D- uridine beta-D- dTMP dCDP dCMP dCTP L-gulono- dUTP an alpha L- an XXLG xyloglucan acetoacetyl- an N10-formyl- 2,3,5,6- 4-fumaryl- glycolysis I pyridoxal a monocarboxylic- aminoacetone a mannan 5-thio- D-mannitol L-canavanine dihydrobiopterin acetylcholine trehalose 4-nitrophenyl 2-oxoglutarate leucocyanidin a sialyloligosaccharide selenohomocysteine and isoleucine biosynthesis cysteine proline diphthamide galactose fructofuranose rhamnoside oligosaccharide CoA tetracholorphenol superpathway of sulfur superpathway glycolysis III glyoxylate cycle arginine acid-amide D-ribose 1,4-lactone a protein acylcholine tetrahydrofolate phosphate acetoacetate biosynthesis IAA Deoxycytidylate dCTP Deoxyuridine amino acid biosynthesis biosynthesis biosynthesis II acetate D-gluconate Uridine Thymidylate Nucleoside of serine biosynthesis V (glucokinase) degradation Aldose 1- kinase: dtymk diphosphate Mannan endo- Mannitol 2- deaminase: Dctd pyrophosphatase 5’-triphosphate Trehalose Beta- Sialidase: IV (fungi) (from arginine) beta-D-glucose- val Amidase: kinase: udk Fructokinase: Copper Arginase- Dihydropteridine Cholinesterase: Alpha-L- Cholinesterase: Hydroxymethylglutaryl- Formate-- Pentachlorophenol 4- Leucoanthocyanidin Fumarylacetoacetase: Fah 5-methyltetrahydropteroyltriglutamate- pyruvate (Saccharomyces an L- and glycine VII (arginase conversion degradation epimerase: Pyridoxal kinase: swoH 1,4-beta- Methylthioribose dehydrogenase: Deoxycytidylate 1: DCTPP1 Gluconolactonase: gnl nucleotidohydrolase: phosphorylase: TP galactosidase: TCNA thr 6-phosphate SSO2122 scrK methylamine 1: Arg1 reductase: qdpr BCHE rhamnosidase: Cathepsin BCHE CoA synthase A: hgsA tetrahydrofolate 4-nitrophenylphosphatase: dioxygenase: A2 histidine succinate acetyl-CoA Galm kinase: PK [+ 2 isozymes] mannosidase kinase: MTK AO090011000230 deaminase: Dctd DUT lacZ monooxygenase: pcpB -homocysteine methyltransferase: metE cerevisiae) biosynthesis I indole-3- beta-D-glucose 3 pathway) to acetyl- oxidase: maoII dTDP Mahau_1189 Z: CTSZ ligase: THFS pho2 [+ 2 isozymes] L-homoserine arg in eEF-2 acetonitrile UMP 1: MAN1 dCMP beta-D- sulfate glyoxylate CoA D-fructose- S-methyl-5- beta-D- (S)-3-hydroxy- fumarate acetoacetate an oligosaccharide N-acetylneuraminate 3-phospho-D-glycerate Branched-chain-amino- D-gluconate alpha-D- dCTP L-gulonate dUMP a non glucose 1- Glucose-6- leucine arg a monocarboxylate 6-phosphate thio-alpha- D-fructose dUMP L-canaline urea tetrahydrobiopterin acetate choline choline a carboxylate glucose XXXG xyloglucan beta-D- 3-methylglutaryl- tetrachlorohydroquinone cyanidin succinate L-serine acid aminotransferase: acetate galactose pyridoxal-P a mannan alpha-L- rhamnosylated a tetrahydrofolate- phosphate isomerase, Glucokinase: glcK Malate synthase, methylglyoxal D-ribose 1- phosphate oligosaccharide galactose CoA formate 4-nitrophenol SeMet dehydratase: sds Nitrilase Glucokinase: glk glyoxysomal: acuE 37018 degradation I oligosaccharide rhamnose rhamnosyl a peptide a peptide glutamate cytosolic 1: PGIC1 Isocitrate lyase: ACU-7 phosphate L-threonine Sulfate Homoserine O- homolog [+ 2 isozymes] Branched-chain- Gluconokinase: acceptor D-3-phosphoglycerate Glucose-6- (S)-2-acetolactate dehydratase adenylyltransferase: acetyltransferase: 2-(3-carboxy- arginine 1: NIT1 amino-acid Arginase- Acetate--CoA gntK biosynthetic dehydrogenase: Phgdh phosphate isomerase, beta-D-glucose- aminotransferase: ilvE MET3 metX 3-aminopropyl) degradation leu 1: Arg1 ligase ACS, IlvA: ilvA Bifunctional 3’- proline -L-histidine [+ 2 isozymes] cytosolic: PGIC 6-phosphate indole- chloroplastic/ phosphoadenosine L-citrulline biosynthesis I VI (arginase 6-phospho- a DNA a [protein]- Ketol-acid citrulline biosynthesis in eEF-2 3-acetate glyoxysomal: dTDP a 1,4-beta- XLXG xyloglucan all-trans- D-gluconate beta-D- containing D-fructose hydrogen N6-D- dCDP a 2- an acetic 7-dehydro- (2R,3S)-2,3- (2R,3S)-2- trehalose a D-glucosyl-N- phosphoryl- a 1,2- reductoisomerase, 5’-phosphosulfate O-acetyl-L- hydrogen 2 pathway) 3-phospho- selenocysteine Glucose-6- 2-oxoisovalerate ACS glucose pyridoxamine ammonia cadaverine homoisocitrate D-glucan N-ethylmaleimide an alcohol hydroxymethylbilane oligosaccharide retinyl Co2+ sirohydrochlorin pentachlorophenol 2-oxoglutarate leucopelargonidin a phospholipid (deoxynucleotides)(m) a deoxyribonucleotide synthase 2: PAPSS2 D-fructose-6-phosphate urea pyrimidine sulfide fructosyl- monoacylglycerol ester cholesterol dimethylmalate methylisocitrate a protein acylsphingosine ethanolamine diacylglycerol chloroplastic: AHRI 2-oxobutanoate homoserine sulfide Diphthine hydroxypyruvate phosphate isomerase, D-threo-isocitrate (S)-malate Probable branched- palmitate biosynthesis L-ornithine [+ 2 isozymes] dimer L-lysine Nucleoside Ribonucleoside- glt synthase: arg chain-amino-acid cytosolic 1: PGIC1 Xylose diphosphate diphosphate Beta- Trehalose Beta- gln dph5 II (archaea and 2-oxoisovalerate aminotransferase: Fructokinase: Sulfite Copper Homoaconitase, 2-acylglycerol O- Acetyl 2,3- Probable Non-lysosomal S-formylglutathione Sirohydrochlorin Leucoanthocyanidin Phospholipid:diacylglycerol DNA ligase (Fragment): 2,3-dihydroxy-3- adenosine 5’- Ornithine Glucose-6- arginine isomerase: Pyridoxal Endonuclease Hydroxylamine reductase large glucosidase N-ethylmaleimide 7-dehydrocholesterol Malonyl CoA-acyl carrier Uroporphyrinogen- galactosidase: Pentachlorophenol 4- Phosphoethanolamine N- dehydrogenase subunit ilvE scrK reductase Fructosamine- kinase: swoH methylamine reductase: nemA Proteinase phosphorylase: TP glucosylceramidase: hydrolase: ESD cobaltochelatase: methylbutanoate phosphosulfate O-acetylhomoserine carbamoyltransferase: 2-[3-carboxy-3- Phosphoserine eukaryotes) phosphate isomerase, acetyl-CoA kinase: PK V: ENDOV reductase: hcp mitochondrial: acyltransferase esterase: aes reductase: DWF5 dimethylmalate methylisocitrate protein transacylase: III synthase, lacZ monooxygenase: pcpB methyltransferase 3: NMT3 dioxygenase: A2 acyltransferase 1: PDAT1 GSTENG00019603001 6-phosphofructokinase Probable aconitate alpha, mitochondrial: [+ 3 isozymes] degradation Ornithine cyclodeaminase: XYLA [ferredoxin]: sir 3-kinase: FN3K [+ 2 isozymes] oxidase: maoII subunit: RNR1 6: BGLU6 lyase 1: prpB1 K: PROK GBA2 [+ 4 isozymes] cbiX [+ 6 isozymes] (thiol)-lyase: cysD argF (methylammonio) aminotransferase: serC cytosolic: PGIC Malate dehydrogenase, ALDEHYDE DEGRADATION LYS4 3: MOGAT3 lyase: Dml CWATWH0003_3818 chloroplastic: UROS Delta-1- Arginase- Fructose-1,6- 3: PFK3 hydratase, BCKDHA X (arginine PHATRDRAFT_54222 [+ 3 isozymes] alpha-D- propyl]-L- 1: Arg1 ser mitochondrial: MDH2 a DNA D-fructose- a [protein]- alpha-D- Dihydroxy-acid Bifunctional 3’- Ferredoxin- pyrroline-5- bisphosphatase, Pyrophosphate-- mitochondrial: aco2 2-oxoisovalerate dTTP a 1,4-beta- beta-D- glucose 1- XXXG xyloglucan beta-D- 2-aceto-2- histidine in eEF-2 4-methyl-2- monooxygenase D-fructose pyridoxamine containing 6-phosphate N6-(3-O- hydroxylamine an alcohol acetate N-ethylsuccinimide cholesterol glucose tetrachlorohydroquinone N-methylethanolamine pelargonidin succinate a triacylglycerol a lysophospholipid dependent L-ornithine carboxylate homoserine chloroplastic: FBP fructose 6-phosphate cis- CDP glucose a 1,2- an acetic phosphate oligosaccharide galactose beta-D- cobalt- dehydratase: ilvD hydroxy- phosphoadenosine D-fructose-6-phosphate dehydrogenase oxopentanoate 5’-phosphate abasic site sulfite phospho- 5-aminopentanal D-glucan propionate pyruvate succinate pyruvate uroporphyrinogen-III a ceramide a retinol palmitate phosphate a deoxyribonucleotide Dihydroxy-acid 5’-phosphosulfate glutamate synthase: biosynthesis 3-phospho-L-serine [+ 7 isozymes] 1-phosphotransferase subunit beta, pathway) homoaconitate diacylglycerol ester a peptide a peptide glucose sirohydrochlorin butanoate Diphthine pro methylglyoxal D-fructosyl) dehydratase: ilvD synthase 2: PAPSS2 synthase P5CS Serine-- Fructose-bisphosphate subunit beta: PFP-BETA mitochondrial: bkdB arg synthase: L-ornithine cis-aconitate oxaloacetate -L-lysine Ketol-acid 2: gltS tRNA ligase, aldolase, chloroplastic: degradation I [+ 3 isozymes] L-homocysteine Ornithine dph5 6-phosphofructokinase reductoisomerase, cytoplasmic: Os11g0171300 phosphoadenosine- aminotransferase, L-glutamate- asp Phosphoserine dihydroxyacetone [+ 3 isozymes] 3: PFK3 Probable aconitate citrulline 2-oxoisovalerate chloroplastic: AHRI phosphatase: PSPH serS fructose-1,6- isobutyryl-CoA 5’-phosphosulfate mitochondrial: Oat 5-phosphate 2-[3-carboxy-3- Ornithine phosphate Pyrophosphate-- hydratase, Arginine methylglyoxal indole- an [alpha- 5-chloro- methyl an L-1- N-(5’- Serine- bisphosphate degradation a sugar dUDP dUDP a 1,4-alpha- XLLG xyloglucan glycyl- nicotinate D- (dimethylammonio) aminotransferase, Phosphoserine fructose 6-phosphate mitochondrial: aco2 decarboxylase: acrylamide shikimate myo-inositol tetrahydrobiopterin 3-glycol ammonia tubuline]- an acyl cellulose a plastoquinone 3’-ketolactose an anilide kynurenine ethanol n-butanol shikimate indole- phosphatidyl- acetyl-CoA 4-hydroxybutyrate coenzyme A o-succinylbenzoate phosphoribosyl) 5,6-dimethylbenzimidazole -tRNA isovaleryl- phosphate 5-deoxy- D-glucan 4-acetamidobutanal a protein oligosaccharide peptide ribonucleotide 2,3-dihydroxy- glt propyl]-L- mitochondrial: Oat phosphatase: PSPH Triosephosphate 1-phosphotransferase speA aldehyde L-lysine D-ribonate phosphate 3-acetate ethanolamine -anthranilate Cysteine L-glutamate ligase: serS CoA Nucleoside Ribonucleoside- 2-isopropylmalate 3-methylvalerate Probable synthase Delta-1- Aspartokinase 3, histidine in eEF-2 isomerase: tpiA subunit beta: PFP-BETA Citrate synthase, L-citrulline Branched-chain- gamma- acetyl-CoA Lactoylglutathione diphosphate diphosphate Major extracellular Alpha- Beta- synthase: leuA phosphoadenosine 2: cys12 semialdehyde pyrroline-5- chloroplastic: AK3 [+ 2 isozymes] mitochondrial: cs lyase, putative: Amidase: Inositol Protein Sepiapterin Aldehyde Hydroxylamine Alpha-tubulin N- Dihydroxy-acid NAD(P)H Beta- Chaperone Probable aldehyde Malonyl CoA-acyl carrier Malonyl CoA-acyl carrier Pentafunctional S-formylglutathione Putative Glycylpeptide N- 4-hydroxybutyrate 2-succinylbenzoate- Anthranilate amino-acid phosphosulfate Bifunctional L-glutamate Shikimate kinase: swoH reductase large Acylphosphatase- endoglucanase: glucosidase galactosidase: Kynureninase: galactosidase: Nicotinate-nucleotide-- Delta-1- carboxylate Diphthine fructose-1,6- 4-guanidinobutyramide oxygenase: CbbY: cbbY reductase: dehydrogenase reductase: hcp acetyltransferase: dehydratase: dehydrogenase protein dehydrogenase: Ananain: protein transacylase: protein transacylase: AROM polypeptide: hydrolase: ESD uncharacterized protein: tetradecanoyltransferase coenzyme A -CoA ligase: menE phosphoribosyltransferase: trpD aminotransferase: Cystathionine [+ 2 isozymes] gamma- ser L-seryl- selenide RCOM_0911940 SSO2122 kinase: aroK [+ 2 isozymes] subunit: RNR1 engXCA yihQ: yihQ kynu lacZ dimethylbenzimidazole Dihydroxy-acid reductase: pro synthase: aspartokinase/ synthase: citrate [+ 6 isozymes] SPR family 3 member PITG_13069 ilvD 2: Acyp2 lacZ AN1 CWATWH0003_3818 CWATWH0003_3818 LACBIDRAFT_233717 [+ 4 isozymes] CHLNCDRAFT_137846 2: NMT2 37018 pyrroline-5- tRNAsec bisphosphate Ornithine [+ 3 isozymes] Miox [+ 3 isozymes] [quinone] 1: NQO1 ClpB: clpB FIS1 transferase: cat2 5-phospho- phosphoribosyltransferase: cobT (2S)-2- dehydratase: ilvD SPAC13G7.06 beta-lyase P5CS homoserine dph5 semialdehyde methylacrylyl-CoA [+ 10 isozymes] Branched-chain- carboxylate carbamoyltransferase: H1: ALDH3H1 an [alpha- 4-(2’- Dihydroxy-acid L-homoserine PatB: patB dehydrogenase dUTP a 1,4-alpha- alpha-D- XXXG xyloglucan beta-D- alpha-D- isopropylmalate amino-acid synthase: argF acrylate shikimate-3- hydroxylamine tubulin]- 5-chloro-4- 3-keto-beta- beta-D- carboxyphenyl)- anthranilate dehydratase: ilvD 2, chloroplastic: methionine biosynthesis II Serine Selenide, S-lactoyl- D-glucuronate a sugar 6-pyruvoyl UDP a carboxylate D-glucan glucose ala indole- a phosphatidyl-N- N-tetradecanoylglycyl- 4-hydroxybutanoyl- ribose 1- alpha- aminotransferase: P5CS L-glutamate L-seryl- Fructose-bisphosphate 3-methylcrotonyl- phosphate hydroxy-2- a cellodextrin a plastoquinol D-galactose glucose aniline a carboxylate 4-acetamidobutanoate anthranilate ethylacetate butyl acetate oligosaccharide galactose 3-dehydroshikimate methanol acetate 4-oxobutyryl-CoA Proline AKHSDH2 hydroxymethyltransferase water Probable enoyl- glutathione tetrahydropterin indole-3- N6-acetyl- a peptide a peptide 3-acetate methylethanolamine peptide CoA diphosphate nicotinate ribazole-5’- ilvE sulfite (S)-1-pyrroline- gamma- diphthine tRNA(Sec) aldolase, chloroplastic: CoA oxopentanoate 3-isopropylmalate dehydrogenase 2: shmt2 dikinase: D-glyceraldehyde- CoA hydratase, glycolate L-lysine phosphate 2-keto-3- Homoserine O- 5-carboxylate semialdehyde in eEF-2 kinase: Pstk Os11g0171300 carbamoyl- dehydratase: IIL1 1, mitochondrial: L-glutamate- [+ 3 isozymes] selD 3-phosphate mitochondrial: echs1 methyl-valerate acetyltransferase: (S)-1- [+ 3 isozymes] 4-guanidinobutyrate phosphate Hydroxyacylglutathione 3-isopropylmalate PRODH 5-phosphate L-homoserine metX L-aspartyl- pyrroline-5- Methylcrotonoyl- hydrolase 3, dehydratase small val Delta-1- O-phospho- methionine Pyrroline-5- 4-phosphate carboxylate Glyceraldehyde- (S)-3-hydroxy- CoA carboxylase mitochondrial: GLY3 3-(all-trans- subunit 2: leuD2 Probable branched- (S)-1- pyrroline-5- L-cystathionine L-seryl- selenophosphate a monoamide (S)-2,3,4,5- a double carboxylate gly 3-phosphate isobutyryl-CoA beta chain, degradation I (to [+ 3 isozymes] a D-hexose D-ribose indole-3- indole D-arabinono- (2R)-3- chitin D-galactono- 5,6,7,8- octaprenyl) guanosine2251 a RAD21 benzyl D-glucuronate salicyl keto- 13-sophorosyloxydocosanoate chain-amino-acid O-acetyl-L- pyrroline-5- carboxylate tRNASec Triosephosphate nicotinamide of a tetrahydropiperidine- chorismate L-idonate tauropine porphobilinogen shikimate HCC 3-demethylubiquinol-8 carbamoyl- L-canaline stranded Probable reductase: PROC1 Homoserine dehydrogenase: GPDA mitochondrial: a protein glyoxal acetaldehyde 1,4-lactone sulfolactate 1,4-lactone a tRNA tetrahydropteridine benzene- in 23S rRNA cohesin alcohol alcohol phosphate asp O-ureidohomoserine phenylpyruvate 6’,6’’-diacetate aminotransferase: homoserine carboxylate synthase: (S)-1- Pyrroline-5- isomerase: tpiA homocysteine) dicarboxylate 2-carboxylate DNA hydrogen sulfide cystathionine Pyrroline-5- Aspartate- kinase: thrB [+ 2 isozymes] Mccc2 1,2-diol subunit 2-isopropylmaleate ilvE P5CS carboxylate dihydroxyacetone[+ 2 isozymes]D-glyceraldehyde- Probable 3- gamma-synthase: Cystathionine carboxylate pyrroline-5- semialdehyde diphthamide Homoserine (R)-lactate Ribokinase: Chitin [+ 3 isozymes] in eEF-2 reductase: O-phosphoseryl- 3-phosphate hydroxyisobutyryl- Amidase: Omega- Aldehyde Fatty Aldehyde L-gulonolactone L-sulfolactate Fibronectin type Dihydropteridine Anthranilate L-idonate 5- Tauropine 3-demethylubiquinone- 23S rRNA Porphobilinogen Malonyl CoA-acyl carrier Putative Pentafunctional S-formylglutathione 3-demethylubiquinone- 4-hydroxyphenylpyruvate Acetyl DNA SPBC15D4.09c gamma- reductase: proC carboxylate kinase: thrB phosphate met CO2 Glucokinase: Ornithine dehydrogenase: asd PROC1 tRNA(Sec) CoA hydrolase 3-methylglutaconyl- SSO2122 amidase glcK rbsK Protease dehydrogenase acyl-CoA dehydrogenase oxidase: Gulo dehydrogenase: deacetylase III domain protein: tRNA- reductase: qdpr synthase: dehydrogenase: dehydrogenase: 9 3-methyltransferase: (guanosine-2’-O-)- Separin: deaminase, protein transacylase: uncharacterized protein: AROM polypeptide: hydrolase: ESD 9 3-methyltransferase: Argininosuccinate dioxygenase: HPD esterase: aes endonuclease 4-aminobutyrate 1: cda1 carbamoyltransferase: 3-isopropylmalate O-acetylhomoserine Cystathionine lyase: cysA Aspartate- Pyrroline-5- selenium 1,3-bisphospho- 3: At2g30660 CoA NIT2: nit2 [+ 2 isozymes] 4: sppA family 3 member synthetase family 3 member [+ 2 isozymes] comC VDG1235_3084 dihydrouridine trpE(G) VIT_16s0100g00290 tadh ubiG methyltransferase cut1 chloroplastic: HEMC CWATWH0003_3818 PHYSODRAFT_347522 LACBIDRAFT_233717 [+ 4 isozymes] ubiG synthase: argG [+ 2 isozymes] RBBP8: gamma- Glyceraldehyde- D-lactate argF 13-[O(2’)-beta-D- dehydratase: IIL1 (thiol)-lyase: cysD Pyrroline-5- semialdehyde carboxylate transferase: D-glycerate 3-hydroxyisobutyryl- [+ 4 isozymes] H1: ALDH3H1 A: fcsA H1: ALDH3H1 synthase A: dusA RlmB: rlmB RBBP8 ile synthase: metB O-phospho- 3-phosphate dehydrogenase: 6,7- 2-methoxy- glucopyranosyl-beta-D- 3-isopropylmalate pro carboxylate dehydrogenase: asd reductase: SEPSECS CoA hydrolase 1: CHY1 S-adenosylmethionine nicotinate D-hexose 6- D-ribose-5- dehydro-D- acetate L-glutamate reductase: L-homoserine dehydrogenase: GPDA ldhA chitosan dihydropteridine 5-dehydro- 6-(all-trans- glucopyranosyloxy]docosanoate dehydratase small proC synthase: metK a dicarboxylate phosphate phosphate arabinono- 3-sulfopyruvate acetate D-galactonate tRNA anthranilate pyruvate pyruvate taurine 2-O- hydroxymethylbilane benzylacetate D-fructuronate 3-dehydroshikimate salicyl-HCH ubiquinol-8 canavaninosuccinate 2-hydroxyphenylacetate gamma- cys [+ 2 isozymes] indole-3- indole- D-gluconate octaprenyl) a peptide a peptide O-ureidohomoserine O(6’’)-acetate subunit 2: leuD2 PROC1 threonine Phosphoglycerate 2-aminoadipate containing 5,6- methylguanosine2251 a 5’-phosphooligonucleotide a 5’ phosphodinucleotide arg semialdehyde (S)-3-hydroxy- a peptide glyoxylate 3-acetate 1,4-lactone phenol Ornithine Pyrroline-5- L-aspartate- biosynthesis L-selenocysteinyl- kinase, dihydrouridine in 23S rRNA carboxylate Probable chloroplastic: PGK isobutyrate Arginase- aminotransferase, semialdehyde 1,3-bisphospho- (S)-3-hydroxy- S-adenosyl- pyruvate (2R,3S)-3- pro from tRNAsec mitochondrial: Oat reductase: cystathionine [+ 3 isozymes] D-glycerate 3-methylglutaryl- L-methionine isopropylmalate L-homocysteine 1: Arg1 proC gamma-synthase: homoserine Putative oxidoreductase CoA SPBC15D4.09c Homoserine a 6-(N-acetyl-D- Phosphoglycerate GLYR1: GLYR1 nicotine- (S)-2,3,4,5- UDP-alpha- 3-isopropylmalate tyrosine dehydrogenase: Cystathionine L-homoserine 3-phospho-D-glycerate [+ 2 isozymes] (3Z)-hex- D-sedoheptulose- indole D,L-malic (3Z)-hex- N-acetyl-L- a calmodulin L,L- benzyl an all-trans- a standard glucosaminyl)- a [protein]- kinase, Hydroxymethylglutaryl- delta1’5’- Fe2+ dihydrobiopterin tetrahydropiperidine- (2R)-3- cysteamine L-idonate A NADH 2-phosphoglycolate NADH A L-quinate CTP a dolichol 3-dehydroquinate HCC leukotriene- 4-hydroxyphenylpyruvate ethylnitronate N-acetyl-D- dehydrogenase: pro hom gamma- his 3-en-ol 7-phosphate acetaldehyde semialdehyde sulfolactate 3-en-ol ornithine gly L-lysine a protein diaminopimelate alcohol retinyl ester alpha 1-phosphatidyl- hydroxyproline biosynthesis I chloroplastic: PGK CoA lyase, 2-carboxylate glucosamine leuB S-adenosyl-L-methionine cycle II Bifunctional synthase: metB iminium ion amino acid C4 1D-myo-inositol Cysteine [+ 3 isozymes] (S)-methylmalonate- mitochondrial: HMGCL synthase 2: cys12 L-ornithine aspartokinase/ Homoserine 2,3-bisphosphoglycerate- semialdehyde S-adenosyl-L- Aldehyde Frataxin, Sepiapterin Alcohol 2-epi-5-epi- Fatty Aldehyde Aldehyde L-sulfolactate SH2 domain Acetylornithine Probable 2- Calmodulin-lysine N- L-idonate 5- NADH-quinone Phosphoglycolate Probable NADH LL-diaminopimelate Pentafunctional Dolichol Pentafunctional S-formylglutathione S-formylglutathione N-acetylglucosaminyl- 4-hydroxyphenylpyruvate Nitronate [Skp1-protein]-hydroxyproline N- chorismate [+ 2 isozymes] homoserine kinase: thrB acidification and Cathepsin (2S)-2-isopropyl- Cystathionine dehydrogenase L-cystathionine L-glutamine dependent homocysteine oxidase Histidine mitochondrial: reductase: dehydrogenase valiolone acyl-CoA dehydrogenase dehydrogenase dehydrogenase: containing protein: aminotransferase: Glycine N- aminoethanethiol methyltransferase: dehydrogenase: oxidoreductase phosphatase: PGP dehydrogenase: aminotransferase: AROM polypeptide: kinase: Dolk AROM polypeptide: hydrolase: ESD hydrolase: ESD Putative gamma- phosphatidylinositol dioxygenase: HPD monooxygenase: acetylglucosaminyltransferase: gnt1 3-oxosuccinate cysteine Homoserine phosphoglycerate 3-phospho-D-glycerate acetoacetate chitin degradation (in 1: AAO1 ammonia- fxn SPR synthase: synthetase family 3 member family 3 member comC Esi_0183_0042 argD methyltransferase dioxygenase: ado-1 Camkmt VIT_16s0100g00290 subunit C: nuoC E: Ctse dapL LACBIDRAFT_233717 LACBIDRAFT_233717 [+ 4 isozymes] [+ 4 isozymes] glutamyltransferase PA1024 beta-lyase met 2, chloroplastic: biosynthesis [NADP(+) [+ 2 isozymes] DDB_G0270104 de-N-acetylase: Pigl [+ 2 isozymes] [Skp1-protein]-hydroxyproline N- PatB: patB Ornithine biosynthesis I kinase: thrB mutase: gpmA Methylmalonate lyase: hutH ]: AKR1A1 acbC A: fcsA H1: ALDH3H1 H1: ALDH3H1 (Fragment): GNMT [+ 5 isozymes] ywrD: ywrD acetylglucosaminyltransferase: gnt1 AKHSDH2 carnivorous plants) 6-(alpha-D- Probable chorismate carbamoyltransferase: II (tRNA- [+ 6 isozymes] semialdehyde [+ 4 isozymes] (3Z)-hex- N-acetyl-L- a calmodulin a dolichyl [unspecified Cystathionine Adenosylhomocysteinase: 5-dehydro- (S)-2,3,4,5- CDP a long-chain glucosaminyl)- a protein-O- argF 2,3-bisphosphoglycerate- dehydrogenase ATP synthase subunit cotinine Fe3+ sepiapterin 3-sulfopyruvate 3-en-1- glutamate 5- hypotaurine N6-methyl- NAD+ A(H2) glycolate 3-dehydroquinate phosphate 3-dehydroshikimate benzyl-HCH all-trans- a 5-L- acetaldehyde nitrite degradation mutase: SPAC16E8.04c beta-lyase dependent) SAHH 2-epi-5-epi- D-gluconate a peptide a peptide tetrahydrodipicolinate retinol fatty acid acetate homogentisate O-phospho- dependent [acylating] 1: iolA1 beta, mitochondrial: ATP2 urocanate 2-aminoadipate indole- (S)-malate yl acetate semialdehyde sarcosine L-lysine glutamyl-L- leukotriene- 1-phosphatidyl- products] (N-acetyl-D- 5-methyltetrahydropteroyltriglutamate- ser ATP ADP valiolone 3-acetate A(H2) NAD+ D4 UDP L-homoserine PatB: patB L-homoserine (S)-3-amino-2- cis-3- 1D-myo-inositol glucosaminyl) -homocysteine methyltransferase: metE glt 2-phospho-D-glycerate phosphoglycerate Probable amino acid methylpropanoate hexenal hydroxyproline 4-methyl-2- prephenate L-citrulline S-adenosylmethionine mutase: gpmA methylmalonate- [+ 2 isozymes] L-homocysteine oxopentanoate synthase: metK [+ 6 isozymes] semialdehyde L-cystathionine Probable serine L-homocysteine Threonine dehydrogenase branched-chain alpha-keto Probable synthase: acetyltransferase Enolase: PGH1 [acylating], Probable branched- Arogenate cystathionine THR4 acid dehydrogenase complex Di-N-acetylchitobiase: CTBS a galactosylated a dietary 2: SAT2 Enolase: PGH1 2-phospho-D-glycerate mitochondrial: mmsdh a long-chain leukotriene an aliphatic nicotinamide a D-glucosyl-N- (2R)-3- N,N- guanine9 N2-succinyl- a cytosine34 S-(2E,6E) O-acetyl-L- N1- (2E,6E)- 3-hydroxy- 7,8- chain-amino-acid dehydrogenase 2, gamma-synthase: Threonine Chitinase domain- agmatine an aldehyde thiamin prostaglandin-H2 L-galactonate methylarsonite citrate galactose all-trans- L-quinate D-galacturonate methylsalicylate methanethiol isochorismate Cystathionine S-adenosyl- a nitrile alcohol A4 amine mononucleotide acylsphingosine sulfolactate dimethylaniline in tRNA L-glutamate 5- in tRNA a protein -farnesyl- homoserine acetylspermidine farnesyl protoheme IX L-kynurenine dihydroneopterin aminotransferase: chloroplastic: TYRAAT2 SPBC15D4.09c L-homocysteine synthase: an [apo BCAA containing protein 1: Chid1 triphosphate semialdehyde acceptor retinyl ester L-cysteine L-methionine chitin a chitodextrin precursor diphosphate triphosphate ilvE Cystathionine gamma-lyase: cysA O-acetyl- thrc L-glutamyl- dehydrogenase E2 2-oxoisovalerate Methionine Methionine 5-methyltetrahydropteroyltriglutamate- Enolase: PGH1 [+ 3 isozymes] gamma- serine L-serine synthase: mtr synthase: mtr -homocysteine methyltransferase: metE tRNAGln bicarbonate protein] N6-(lipoyl)lysine dehydrogenase subunit Nitrilase Long-chain- Leukotriene Copper Cytosolic 5’- Sphingolipid Putative Aldehyde L-sulfolactate Thromboxane- Fibronectin type Flavin-containing Arsenite tRNA Probable aldehyde (3S)- Beta- Lipase: Pentafunctional Putative S-formylglutathione Probable ORF: Enolase: PGH1 Thiamine- Farnesylcysteine O-acetylhomoserine Protoheme IX Kynureninase: Putative 6- 4-hydroxyphenylpyruvate synthase: metB [+ 2 isozymes] [+ 2 isozymes] alpha, mitochondrial: homolog alcohol A-4 hydrolase methylamine nucleotidase delta(4)- agmatine dehydrogenase dehydrogenase: A synthase: III domain protein: monooxygenase methyltransferase: (guanine(9)-N1)- dehydrogenase: malyl-CoA galactosidase: tRNA (cytosine(34) Nardilysin: Esi_0000_0546 AROM polypeptide: uncharacterized protein: hydrolase: ESD polyamine evm.model.contig01471.1 Adenosylhomocysteinase: racemization [+ 2 isozymes] phosphoenolpyruvate 2-ketoglutarate triphosphatase: lyase: FLCY (thiol)-lyase: cysD farnesyltransferase, kynu carboxy-5,6,7,8- cys BCKDHA 1: NIT1 oxidase homolog: lkhA oxidase: maoII 3: nt5c3 desaturase deiminase: family 3 member comC Tbxas1 VDG1235_3084 FMO GS-OX3: As3mt methyltransferase: FIS1 thioesterase: lacZ -C(5))- Nrd1 [+ 22 isozymes] LACBIDRAFT_233717 PHYSODRAFT_347522 [+ 4 isozymes] oxidase [+ 2 isozymes] SAHH thr THTPA mitochondrial: COX10 tetrahydropterin Cysteine Glutamyl-tRNA(Gln) 2-oxoisovalerate dehydrogenase complex FAO1: FAO1 Cytosolic 5’- DES1: degs1 aguA H1: ALDH3H1 FMOGS-OX3 trm10 mcl2 methyltransferase: 4: PAO4 leu met phosphoenolpyruvate a non synthase: queD synthase amidotransferase dehydrogenase nucleotidase nsun2 Tyrosine S-adenosyl-L-methionine cycle I ser leukotriene L-galactono- N2- galactosylated beta-D- all-trans- a long-chain (2E,6E) 2,3-dihydroxy-2,3- 2: cys12 subunit A: gatA subunit beta, a [2-oxoglutarate a carboxylate an aldehyde 3-sulfopyruvate thromboxane A2 nn- cacodylate N1- cys 3-dehydroquinate D-tagaturonate acetate met 3-hydroxyanthranilate ala pyruvate aminotransferase: TAT AROMATIC COMPOUNDS a long-chain B4 III: NT5C3 a D-glucosyl-N- thiamin 1,4-lactone succinylglutamate galactose galactose a peptide a peptide retinol -farnesal salicylate methanol heme o [+ 2 isozymes] Pyruvate kinase: pyk N-carbamoylputrescine dimethylaniline- fatty acid dihydrobenzoate 6-carboxy-5,6,7,8- [+ 3 isozymes] mitochondrial: bkdB dehydrogenase E2 DEGRADATION acylsphingosine a carboxylate diphosphate methylguanine9 acetate oxaloacetate putrescine 3-acetamidopropanal [+ 3 isozymes] Pyruvate kinase: pyk Probable 2-oxoglutarate aldehyde n-oxide in tRNA acceptor a 5 methylcytosine34 PPPi acetaldehyde glutamate Dihydrolipoyl protein] N6-(lipoyl)lysine nicotinamide tetrahydropterin S-adenosyl- [+ 3 isozymes] proline dehydrogenase E1 in tRNA precursor S-adenosyl-L- Probable dehydrogenase: lpdA riboside tyr L-methionine serine biosynthesis I L-glutaminyl- degradation component DHKTD1 homocysteine cys an [apo[+ BCAA 3 isozymes] an [apo BCAA dehydrogenase Dihydrolipoyl homolog, mitochondrial: odhA racemase: srr tRNAgln dehydrogenase E2 protein] N6-(S-[2- pyruvate dehydrogenase: lpdA [+ 2 isozymes] urate hypusine pyruvate E2 protein] N6- methylpropanoyl]dihydrolipoyl) Dihydrolipoyl dehydrogenase, degradation (9S,10S)-10- a dipeptide biosynthesis gln ACETYL-COA BIOSYNTHESIS pro (dihydrolipoyl)lysine lysine a trans3,cis- UDP-N- formyl-L- all-trans- 2-dehydro- glutamate mitochondrial: LPD type-1 a primary (2E,6E) hydroxy-9- 4-amino-2-methyl-5- an (3R)-3- with proline a DNA a methyl a L-prolyl N1- nicotinate D- an alkylated D-serine to allantoin an aldehyde riboflavin 5-dienoyl- nitrite mannitol-1- cholesterol a quinone pyruvate cocaine arsenite acetylmuramate prephenate methionyl uroporphyrinogen-III NADPH NAD+ retinyl dimethylallyl 3-deoxy-D- acetylspermine a tRNA ribonucleotide biosynthesis IV transmemberane amine CoA -farnesol phosphate (phosphonooxy) phosphomethylpyrimidine peptide hydroxymyristoyl- at carboxy cyclobutadipyrimidine jasmonate peptide diphosphate galactonate- DNA an eIF5A octadecanoate terminal palmitate a [2-oxoglutarate urate domains FAD linked [acp] 6-phosphate lysine S-adenosylmethionine Glutamate Proline a [2-oxoglutarate dehydrogenase Aldehyde Riboflavin Copper Delta(3,5)- Nitrate reductase Sterol-4-alpha- NAD(P)H Pyruvate Cocaine Lipid Arsenite Thiamine- oxidase domain- Arogenate Peptide Probable NAD(P) S-formylglutathione S-formylglutathione Probable Nicotinate Putative 3- synthase: metK synthase superpathway of acetyl- dehydrogenase dehydrogenase E2 protein] Alcohol Xaa-Pro Hydrolase, putative: Proline S-adenosyl-L- asparagine alanine RESPIRATION E2 protein] N6-(S- oxidase Delta(2,4)- Mannitol 1- methyltransferase: containing protein: (3R)- uroporphyrinogen-III transhydrogenase, hydrolase: ESD tRNA 2-dehydro-3-deoxy-6- met glutamate gln 1 [NADH], CoA biosynthesis 1, mitochondrial: 2-oxoisovalerate N6-(dihydrolipoyl)lysine Rhomboid kinase: Rfk methylamine dehydrogenase: [NADH], clone carboxylate 3- dehydrogenase carboxylase, esterase: phosphate phosphate dehydrogenase deformylase 1B, dipeptidase: RCOM_1499940 hydrolase: ESD iminopeptidase: pip polyamine phosphoribosyltransferase: methyladenine glutamate homocysteine glutamate succinyldihydrolipoyl)lysine 1: AAO1 [+ 2 isozymes] dienoyl-CoA phosphate phosphatase As3mt Esi_0523_0007 hydroxymyristoyl- [+ 4 isozymes] mitochondrial: NNT [+ 4 isozymes] dimethylallyltransferase phosphogalactonate Deoxyhypusine biosynthesis I chloroplastic: biosynthesis III PRODH dehydrogenase subunit protease oxidase: maoII adh PBNBR1412: dehydrogenase, [quinone] 1: NQO1 mitochondrial: PC cocE synthase: 2, chloroplastic: chloroplastic: PEPD C-methyltransferase: [+ 4 isozymes] oxidase naprt DNA biosynthesis V biosynthesis III Uricase: UOX gluP: gluP isomerase, [+ 7 isozymes] NIA2 dehydrogenase: decarboxylating: 2: LPP2 thiE [+ 13 isozymes] TYRAAT2 PDF1B [acyl-carrier-protein] SPCC1739.06c 4: PAO4 9: IPT9 aldolase: dgoA glycosylase: synthase: Dhps GLT1 biosynthesis II alpha, mitochondrial: MPDH2 5-phospho- Glutamate pyruvate BCKDHA mitochondrial: Nsdhl UDP-N- dehydratase: fabZ a DNA pair DSY3705 pyruvate Glutamate aerobic respiration (cytochrome c) a [pyruvate (S)-1- methyl a jasmonic all-trans- alpha-D- [+ 2 isozymes] a carboxylate FMN an aldehyde Ech1 a quinol oxaloacetate benzoate methylarsonate a standard of adjacent NADH NADP+ methanol palmitate a peptide pro a tRNA containing N6- D-glyceraldehyde- nicotinate 2-oxoglutarate asp synthase synthase cys dehydrogenase pyrroline-5- cleaved type-1 (2E,6E) ecgonine (9S,10S)-9,10- 4-amino-2-methyl-5- acetylglucosamine- methionyl acid retinol pyruvate ribose 1- an eIF5A 2 [NADH], 2-oxoglutarate Dihydrolipoyllysine- nitrate D-fructose- enolpyruvate 4-hydroxyphenylpyruvate formate pro alpha pyrimidines precorrin-1 spermidine 3-acetamidopropanal dimethylallyladenosine 3-phosphate a DNA 2-oxoglutarate gln 1 [NADH], E2 protein] N6- carboxylate 5-hydroxyisourate transmemberane -farnesal 6-phosphate cholest-5- dihydroxyoctadecanoate diphosphomethylpyrimidine peptide a trans diphosphate 5-methyltetrahydropteroyltriglutamate- chloroplastic: citrate residue succinyltransferase a trans- amino acid containing 7-methylguanine 3-methyladenine 7-methyladenine 3-methylguanine deoxyhypusine chloroplastic: (lipoyl)lysinePyruvate domains en-3-one tetradec-2- -homocysteine methyltransferase: metE Os05g0555600 NADH component of 2-oxoglutarate 2,trans-4- enoyl-[acp] a purinic site NADP-specific Asparagine GLT1 Probable cysteine dehydrogenase glutamine dehydrogenase complex, dienoyl-CoA [+ 2 isozymes] S-ribosyl-L- Dihydrolipoyl Ferredoxin- L-homocysteine glutamate synthetase [+ 3 isozymes] desulfurase, Glutamate E1 component mitochondrial (Fragment): dlst 5-hydroxyisourate Deoxyhypusine homocysteine UQ Succinyl-CoAdehydrogenase: degradation II dependent dehydrogenase: [glutamine- mitochondrial: dehydrogenase ligase [ADP- subunit beta: pdhB hydrolase: hiuH hydroxylase: dohh lpdA Dihydrolipoyllysine- glycine cleavage complex glutamate gdh hydrolyzing]: glt CG12264 2: glud2 forming] [+ 2 isozymes] 5-carboxyamino- UDP-N- Dihydrolipoyl residue 5-hydroxy-2- a single (S)- synthase 2: gltS [+ 3 isozymes] Os06g0265000 glt Probable cysteine subunit alpha-1,dehydrogenase, all-trans-13,14- a phenol apo-4’- trehalose 6- D-fructose- 2-oxo-3-hydroxy-4- an (R)-3- an 1-chloro-2,4- a purine a guanine26 an aryl N-acetyl-O- 1-(5-phospho- N5-carboxyaminoimidazole ditrans,octacis- acetylmuramoyl- acetyltransferase glt gln oxo-4-ureido- an aldehyde a phenolic stranded butanal nitrite mannitol-1- methylmalonyl- a polypeptide 2-phenylethylamine precorrin-1 RX glutathione an glutathione tributyrin [+ 3 isozymes] an eIF5A- [+ 3 isozymes] desulfurase: csd mitochondrial:mitochondrial: LPD a [glycine- dihydroretinol sulfate donor lycopenal phosphate 6-phosphate phosphobutanoate fumarate asp hydroxyoctanoyl- oligopeptide oligopeptide dinitrobenzene ribonucleoside in tRNA dialkyl acetylneuraminate glutathione hypoglycin A D-ribosyl) ribonucleotide undecaprenyl L-alanyl-gamma- component 2,5-dihydro- DNA phosphate CoA hypusine glt SCOA a [pyruvate a [pyruvate cleavage complex [acp] phosphate imidazole phosphate D-glutamyl-L- of pyruvate 1H imidazole- ATP-citrate dehydrogenase dehydrogenase H protein] N6- lysyl-D-alanine glt dehydrogenase (lipoyl)lysine 5-carboxylate Aldehyde All-trans- Putative L- DNA Alcohol Nitrate reductase Propionyl-CoA Aminopeptidase Copper Probable aldehyde Probable Probable Phosphoserine Glutathione Glutathione Purine nucleoside tRNA (guanine(26) Predicted protein: synthase: ACLY E2 protein] N6- E2 protein] N6-(S- Glutamate glutamate Iduronate 2- Mannitol 1- 6-phosphofructo- Protease Oligopeptidase Phosphotriesterase- Sialate O- Phosphoribosylaminoimidazole Phosphoribosylaminoimidazole glt asn ala complex, oxidase retinol sulfatase: Ids ascorbate primase dehydrogenase: [NADH], clone carboxylase N: pepN methylamine dehydrogenase: pseudouridine-5’- uroporphyrinogen-III aminotransferase: S-transferase L-aspartate (3R)- S-transferase phosphorylase -N(2))- MICPUN_62507 acetylesterase: Putative gamma- UDP-N-acetylglucosamine- (dihydrolipoyl) acetyldihydrolipoyl) synthase phosphate 2-kinase 1: PFK26 4: sppA A: prlC related protein: carboxylase: ade6 carboxylase: ade6 mitochondrial: Dlat Dihydrolipoyl degradation 1: AAO1 13,14- [+ 4 isozymes] peroxidase large adh PBNBR1412: beta chain, [+ 2 isozymes] oxidase: maoII FIS1 monophosphatase: C-methyltransferase: serC L3: GSTL3 oxidase: hydroxymyristoyl- L3: GSTL3 1: punA dimethyltransferase: [+ 25 isozymes] glutamyltransferase Probable NADH lysine lysine 1 [NADH], dehydrogenase: [+ 2 isozymes] [+ 4 isozymes] v1g177083 Siae -dolichyl-phosphate N- [+ 2 isozymes] dehydrogenase: Glycine reductase: 6: APX6 subunit: NIA2 mitochondrial: Gs1l SPCC1739.06c nadB [acyl-carrier-protein] Trmt1 [+ 2 isozymes] ywrD: ywrD 5-amino-1- AROMATIC COMPOUNDS BIOSYNTHESIS dehydrogenase: acetyl-CoA chloroplastic: IX (via 4- [+ 7 isozymes] MPDH2 [+ 3 isozymes] [+ 3 isozymes] 5-amino-1- acetylglucosaminephosphotransferase: lpdA dehydrogenase Retsat [+ 6 isozymes] Prim2 PCCB [+ 6 isozymes] 4-phospho- dehydratase: fabZ alpha-D- (5-phospho- (5-phospho- DPAGT1 DDB_G0270104 GLT1 aminobutyrate) apo-4’- beta-D- Dihydrolipoyl [decarboxylating]: a carboxylate a phenol [+ 2 isozymes] a polypeptide phenylacetaldehyde hydroxy-L- a glutathione- a peptide a peptide 2,4- a purine base ribose-1- 1,2-dibutyrin n-butanoate a dialkyl D-ribosyl) D-ribosyl) [+ 13 isozymes] Glutamate S-allantoin a phenoxyl lycopenoate fructose 2,6- alpha- an N2dimethylguanine26 a phenol N-acetylmuramoyl- a reduced dehydrogenase, gcvP n-butanol nitrate D-fructose- precorrin-2 threonine toxin HX succinate a peptide a peptide dinitrophenyl- phosphate phosphate N-acetylneuraminate hypoglycin B cysteinylglycine imidazole-4- O2 synthase glt all-trans- radical of propanoyl- trehalose bisphosphate iminosuccinate a trans in tRNA acetate imidazole-4- L-alanyl-gamma-D- cytochrome c mitochondrial: LPD 6-phosphate conjugate S-glutathione carboxylate carboxylate UMP 3-dehydroquinate a [glycine- 2 [NADH], retinol a phenolic CoA oct-2- glutamyl-L-lysyl- D-alanyl- FATTY ACIDS AND LIPIDS BIOSYNTHESIS o-diquinones a [glycine-cleavage a short RNA biosynthesis I cleavage complex chloroplastic: donor Segment enoyl-[acp] diphosphoundecaprenol biosynthesis H protein] N6- complex H protein] N6- Os05g0555600 PHOTOSYNTHESIS Glutamate (dihydrolipoyl) (aminomethyldihydrolipoyl) D-erythrose- decarboxylase: lysine lysine 4-phosphate catechol GAD 2,5-diamino-6- an electron- 6,7- 3alpha,7alpha- phosphatidylglycerol glt 2-trans,5-cis- alpha-L- 31-O- a plasma an L-1- ceramide cardiolipin phosphatidylcholine phosphatidylethanolamine Glutamate a trans-2- (S)-2-amino-6- (5-phospho-D- a supercoiled a negatively a 1,2- propanoyl- transfer- dimethyl-8- a (R)-3- N-acetyl-L- dihydroxy-24- N1- triacylglycerol sphingomyelin oxygenic photosynthesis glutamine cyanate supercoiled nitrite H2O tetradecadienoyl- galactose-1- desmethylFK- retinol- all-trans- a polypeptide phosphatidyl- canavaninosuccinate Glc3Man9GlcNAc2 coenzyme A L-methionyl- 10-formyl- a phosphatidylcholine S-adenosyl- biosynthesis II biosynthesis decarboxylase: enoyl-CoA oxohexanoate ribosylamino) diacylglycerol CoA related phe (1-D-ribityl) hydroxybehenoyl- a protein a protein ornithine a peptide oxo-5beta- acetylspermine tyr biosynthesis biosynthesis II biosynthesis I metabolism biosynthesis III duplex DNA CoA phosphate 506 binding retinol ethanolamine tRNAfmet tetrahydrofolate L-methionine (non-plastidic) Phospho-2- GAD degradation I pyrimidin- DNA quinone lumazine [acp] cholestanoyl CoA Tyrosinase: Aminomethyltransferase: protein dehydro-3- melC2 Cytochrome NAD+ 4(3H)-one Mannosyl- palmitoyl- gcvT Cyanate 2,4-dienoyl- Fatty ATP- Topoisomerase Nitrate reductase Propionyl-CoA Acyl-coenzyme NAD(P)H Probable enoyl- Probable Methyltransferase Riboflavin Group XIIA Argininosuccinate 3-ketoacyl- Probable Group XIIA dihydroxyacetone sn-glycerol- a CDP-diacylglycerol choline an L-1- deoxyheptonate Cytochrome b-c1 complex H2O Probable Dipeptidyl Acetylornithine oligosaccharide CoA a ceramide 4-hydroxyphenylpyruvate [+ 2 isozymes] hydratase: CoA acyl-CoA Riboflavin [NADH], clone carboxylase A thioesterase CoA hydratase, pseudouridine-5’- Aspartate peptidase synthase (3R)- Protease secretory Prolyl lyase: ASL Carboxypeptidase CoA thiolase, polyamine Methionyl-tRNA secretory phosphate 3-phosphate phosphatidylserine aldolase 1, c oxidase subunit Rieske, taurine 4-aminobutyrate gln dependent 6 subunit diacylglycerol dehydrogenase FkbM family: deacetylase: argE glucosidase: 2-iminoacetate CYN reductase synthetase biosynthesis DNA B: TOP6B PBNBR1412: beta chain, 9, mitochondrial: [quinone] 1: NQO1 mitochondrial: monophosphatase: Tpen_1716 aminotransferase, 3: dpp3 alpha hydroxymyristoyl- 4: sppA phospholipase endopeptidase: Argininosuccinate Y: CPY1 mitochondrial: oxidase formyltransferase: fmt phospholipase chloroplastic: biosynthesis 1,2- subunit 1: ctaD mitochondrial: kinase 3: dgk-3 an all-trans- MOGS synthase: thiH degradation IV [NADPH]: A: fcsA protein helicase [+ 7 isozymes] NIA2 mitochondrial: Acot9 echs1 Gs1l [+ 2 isozymes] mitochondrial: aatA chain: rib5 [acyl-carrier-protein] [+ 4 isozymes] A2: PLA2G12A Prep lyase: ASL ACAA2 4: PAO4 A2: PLA2G12A Serine Choline/ethanolamine SHKA benzoquinone [+ 6 isozymes] FES1 [+ 3 isozymes] an electron- retinol- Probable CDP- Sphingomyelin fadH RibD: ribD recQ: recQ PCCB [+ 6 isozymes] dehydratase: fabZ Glycerol-3- palmitoyltransferase Phosphatidylserine [+ 3 isozymes] succinate transfer- (plasma- N-formyl-L- diacylglycerol--glycerol- kinase: Chkb synthase- 3-deoxy- Ferredoxin- CO2 [+ 6 isozymes] a 1,2- 3-hydroxy-5-cis- 5-amino-6-(D- a 2-lyso- L-ornithine acetate a C-terminal phosphate O- 1: Sptlc1 Choline kinase alpha: Chka synthase 2: PTDSS2 tyr ornithine 5-amino-6-(5- a relaxed related keto- retinol- N-terminal Glc2Man9GlcNAc2 D-glucose a peptide N1- tetrahydrofolate methionyl- alpha- 3-phosphate 3- related protein D-arabino- taurine dependent a trans- 2-aminoadipate nitrate diacyl-sn- (S)- a carboxylate tetradecenoyl- FK-506 a peptide ribitylamino) riboflavin a fatty acid phosphatidyl- L-canavanine fumarate amino acid chenodeoxycholoyl- propanoyl- 3-aminopropanal a 2-lysophosphatidylcholine acyltransferase Serine phospho-D- DNA quinol beta-L- phenylpyruvate binding- dipeptide a trans- a peptide a peptide a peptide a peptide CoA CoA acetylspermidine tRNAfmet linolenate 2-iminoacetate 4-methylphenol 5’-deoxyadenosine met phosphatidyltransferase: 1: SAMD8 heptulosonate- degradation glutamate 2,trans-4- methylmalonyl- CoA ethanolamine 3-phosphoinositide biosynthesis 1: SCT1 palmitoyltransferase an L-1- ribosylamino) a single glycerol-3- galactose protein) uracil docos-2- pgs1 7-phosphate I (proline synthase dienoyl-CoA stranded phosphate CoA sn-glycerol-3-phosphate 2: SPTLC2 phosphoryl-choline phosphatidyl- a plastoquinol O2 Alpha-ketoglutarate- uracil enoyl-[acp] [+ 2 isozymes] Tyrosine biosynthesis) 2: gltS DNA a 1-acyl-sn- ethanolamine dependent taurine L-serine a sphingomyelin 3-dehydroquinate aminotransferase: TAT [+ 3 isozymes] myo-inositol glycerol-3- synthase: MJ1249 dioxygenase: tauD an L-1- L-ornithine degradation phosphate 3-dehydrosphinganine Choline-phosphate Cytochrome b6-f Alpha-ketoglutarate- Glycerol-3-phosphate O- phosphatidylglycerol- [+ 2 isozymes] complex subunit 4: petD a protein UDP-N- cytidylyltransferase B: Pcyt1b dependent taurine trans-delta2- OPC8-3- (R)- (S)-3- a protein- (E)-2- a DNA 3-oxo-3- a 2,3,4- 3alpha,7alpha,12alpha- acyltransferase 1: SCT1 phosphate 4-hydroxyphenylpyruvate Cytochrome b6- (S)-2-amino-6- a relaxed succinate D-threo- (6E)-8- D-glyceraldehyde- 5-hydroxyindole Mg- 17-alpha- a carboxylic a (R)-3- with N- a tRNA [procollagen]- a (mannosyl)9-(N- a long-chain acetylmuramoyl- CDP-diacylglycerol- Probable 1- dioxygenase: tauD glt prephytoene decenoyl- vernolate hydroxyacyl- nitrite methylmalonyl- hydroxybutanoyl- L-glutaminyl- gamma- benzylidenesuccinyl- containing 2-oxoglutarate coenzyme A phenylpropionyl- saturated L- CTP coenzyme A trihydroxy-24-oxo-5- NADP+ coenzyme A ditrans,octacis- H2O an oxidized f complex iron- ser oxohexanoate DNA semialdehyde isocitrate hydroxygeranial 3-phosphate acetaldehyde protoporphyrin hydroxypregnenolone ester hydroxybehenoyl- terminal uridine38-40 L-proline acetylglucosaminyl)2 aldehyde L-alanyl-gamma- -inositol 3- 3-dehydroquinate Ornithine cyclodeaminase: diphosphate CoA CoA CoA CoA peptide glutamate CoA a mismatch CoA phosphatidate beta-cholestanoyl CoA undecaprenyl acyl-sn-glycerol- CDP-choline cytochrome c sulfur subunit 1, [acp] aspartate D-glutamyl-L- a 1-acyl-sn-glycerol- phosphatidyltransferase 3-phosphate Phosphatidylglycerophosphatase PHATRDRAFT_54222 phosphate 1: PIS1 GEP4, mitochondrial: GEP4 cyanelle: petC-1 lysyl-D-alanyl- 3-phosphate acyltransferase: aminoacetaldehyde 2,4-dienoyl- Fatty Epoxide Trifunctional Topoisomerase Nitrate reductase Succinate- Isocitrate Methylmalonyl- Alcohol Probable enoyl- Glyceraldehyde- Alcohol Magnesium- Sterol-4-alpha- Cocaine Gamma- Probable enoyl- G/T mismatch- Aspartyl Predicted protein Prolyl 4- 3-ketoacyl- Probable alpha- Phosphatidate 3-ketoacyl- Isovaleryl-CoA D-alanine sphingosylphosphorylcholine L-serine Phytoene CoA acyl-CoA [NADH], clone semialdehyde dehydrogenase CoA mutase, CoA hydratase, Glutaminyl-peptide protoporphyrin O- carboxylate 3- CoA hydratase, specific hydroxylase CoA thiolase, SLC1 a sphinganine Cholinephosphotransferase glutamate hydrolase enzyme 6 subunit dehydrogenase: 3-phosphate dehydrogenase: esterase: (3R)- glutamyl aminopeptidase: (Fragment): mannosidase I cytidylyltransferase: CoA thiolase, dehydrogenase, an L-1- dehydratase: synthase: reductase synthetase PBNBR1412: dehydrogenase [NADP], cyclotransferase: methyltransferase: thymine DNA UDP-N-acetylglucosamine- [+ 4 isozymes] (C18) an L-1-phosphatidyl- pro 4: Ephx4 subunit alpha, B: TOP6B mitochondrial: adh mitochondrial: dehydrogenase gbsB dehydrogenase, cocE hydroxymyristoyl- hydrolase mitochondrial: DNPEP MICPUCDRAFT_6886 subunit mitochondrial: MNS4: MNS4 cdsA mitochondrial: mitochondrial: Ivd Probable 1-acyl-sn- phosphatidyl- 1: Chpt1 degradation I sds crtB cardiolipin glycerol a reduced plastocyanin [NADPH]: A: fcsA Epoxide mitochondrial: [+ 6 isozymes] NIA2 [NADP(+)] mitochondrial: MUT [+ 7 isozymes] echs1 2: gpd3 QCT [+ 2 isozymes] chlM decarboxylating: [+ 6 isozymes] [acyl-carrier-protein] A: gghA echs1 glycosylase: [+ 21 isozymes] alpha: phyA ACAA2 [+ 2 isozymes] [+ 2 isozymes] ACAA2 [+ 8 isozymes] -dolichyl-phosphate N- glycerol-3-phosphate inositol fadH GabD: gabD Idh2 Tdg acetylglucosaminephosphotransferase: a 1,2- biosynthesis I hydrolase HADHA [+ 2 isozymes] magnesium- Nsdhl dehydratase: fabZ acyltransferase: SLC1 diacyl-sn- all-trans- 2: EPHX2 [+ 2 isozymes] a negatively [procollagen] a CDP-2,3,4- DPAGT1 a phosphatidylcholine glutamate trans-delta2, succinyl- (6E)-8- crotonyl- a 5- protoporphyrin 2-carboxymethyl-3- a tRNA benzoyl- a (mannosyl)8-(N- propanoyl- a long-chain [+ 4 isozymes] glycerol-3- Probable cardiolipin glt pyruvate phytoene 2-aminoadipate supercoiled nitrate 1,3- 5-hydroxytryptophol pregn-5- an alcohol a carboxylate a DNA asp a peptide trans 4-hyroxy- succinate acetyl-CoA D-mannose saturated- choloyl-CoA NADPH Phosphatidylinositol Phosphatidylinositol cis-delta4- CoA oxogeranial CoA oxoprolyl- IX 13- a trans- hydroxyphenylpropionyl-CoA pseudouridine38-40 CoA CoA acyl-CoA N-acetylmuramoyl-L-alanyl- phosphate phosphatidylethanolamine degradation X OPC8-3- DNA succinate 2-oxoglutarate ene-3,20- glt a peptide containing thymine L-proline acetylglucosaminyl)2 diacylglycerol 4-kinase beta 3-kinase catalytic a CDP-diacylglycerol synthase 1: crls-1 decadienoyl- 12,13- bisphospho- peptide monomethyl ester docos-2- gamma-D-glutamyl-L- ketoacyl- dione-17-ol abasic site UMP a 1,2-diacyl-sn- 1: PI4KBETA1 subunit type 3: Pik3c3 biosynthesis II CoA dihydroxyoctadeca- D-glycerate enoyl-[acp] lysyl- D-alanyl-D-alanine- Phosphatidate a dihydroceramide choline OTHER 9-enoate CoA glycerol-3-phosphate phosphatase cyclopropane Glutamate diphosphoundecaprenol [+ 3 isozymes] a 1- biosynthesis III ketolysis UQH2 glt LPIN2: Lpin2 a cardiolipin fatty acid dehydrogenase a 1- phosphatidyl- Probable CDP- ethanolamine a reduced ferredoxin asparagine diacylglycerol--glycerol- 2: glud2 phosphatidyl- 1D-myo- (CFA) degradation I RNase G a dipetide RNase 7-aminomethyl- Phosphatidate 3-phosphate 3- phosphoryl- (R)-3- fumarate a [methionine 15,16- OPC6-3- 3-oxo-3- S-(2- a DNA 1D-myo- inositol 3- a 1,2- biosynthesis 6-hydroxymethyl- a secondary succinate campest-4- histone- degradation 6-phospho- a beta-D an (R)-3- with a (R)-3- III mRNA a sugar-1- UDP-D- 7-deazaguanine cytidylyltransferase: cdsA phosphatidyltransferase: choline a phospholipid hydroxybutanoate Glutamate AMINES AND POLYAMINES DEGRADATION prephytoene synthase]- epoxyoctadeca- hydroxyacyl- an alcohol (S)-nicotine prephenate glucoside UQ ethanol NADPH NAD+ uroporphyrinogen-I coenzyme A phenylpropionyl- UTP a sterol hydroxyacyl) containing [+ 2 isozymes] inositol 4- phosphate diacylglycerol dehydrogenase diphosphate 7,8-dihydropterin alcohol semialdehyde en-3beta-ol L-lysine ser substrate D-gluconate a protein hydroxydecanoyl- aspartate at hydroxylignoceroyl- a protein processing phosphate glucose S-adenosyl- at position pgs1 olefinic NADPH:adrenodoxin 2-oxoglutarate methylcob(I) 9,12-dienoate CoA CoA glutathione abasic site phosphate 2: glud2 mRNA [acp] N-terminal [acp] substrate L-methionine 34 of a tRNA 1-phosphatidylinositol- Diacylglycerol O- a ceramide [+ 2 isozymes] Choline-phosphate fatty acid oxidoreductase, asn alamin D-beta- Beta- containing 3-phosphate 5- Phospholipid:diacylglycerol acyltransferase acyl-CoA cytidylyltransferase mitochondrial: fdxr Epoxide Trifunctional Alcohol Alcohol Succinate- Sterol-4-alpha- Flavin-containing Histone-lysine N- Phenylalanine-4- Ribonuclease H2 Probable 3- Alcohol Soluble pyridine Ribonuclease H2 Uroporphyrinogen 3-ketoacyl- UDP-sugar Sterol 3-beta- Hydroxyacylglutathione Probable a CDP-diacylglycerol Phosphatidylinositol- hydroxybutyrate Phytoene Folic acid glucosidase Probable GUN anticodon kinase: PIKFYVE acyltransferase 1: PDAT1 2: DGAT2 phosphoryl- B: Pcyt1b Cyclopropane- Ferredoxin--NADP Methionine hydrolase enzyme dehydrogenase: dehydrogenase: semialdehyde carboxylate 3- monooxygenase methyltransferase Serine 3- hydroxylase: pah subunit A putative: hydroxyisobutyrate Imm downregulated dehydrogenase: (3R)- dipeptidase: (3R)- Protease nucleotide subunit A putative: decarboxylase: hemE CoA thiolase, pyrophosphorylase glucosyltransferase: hydrolase 3, endonuclease III 4-phosphate 5- an L-1- fatty acid hydrolysis SECONDARY METABOLITES BIOSYNTHESIS dehydrogenase, 2-oxoglutarate synthase: synthesis 6: BGLU6 [+ 11 isozymes] ethanolamine fatty-acyl- glycerol-3- reductase, embryo allantoin urea synthase protein 4: Ephx4 subunit alpha, gbsB gbsB dehydrogenase dehydrogenase, FMO GS-OX3: ATXR2: ATXR2 dehydrogenase: Arogenate AlNc14C123G6738 dehydrogenase, 3: Esi_0015_0185 gbsB hydroxymyristoyl- hydroxymyristoyl- 4: sppA transhydrogenase: AlNc14C123G6738 Uroporphyrinogen mitochondrial: 1: USP1 ATG26 mitochondrial: GLY3 homolog: nth-1 S-adenosylmethionine:tRNA kinase its3: its3 phosphatidylglycerol- activation mitochondrial: L-asparaginase crtB [+ 2 isozymes] pipD 1-phosphatidyl- a 2,3,4- phospholipid phosphate isozyme, chloroplastic: degradation to degradation II reductase: Epoxide mitochondrial: [+ 2 isozymes] [+ 7 isozymes] [NADP(+)] decarboxylating: FMOGS-OX3 [+ 16 isozymes] sdh dehydrogenase Ribonuclease mitochondrial: hibA [+ 2 isozymes] [+ 2 isozymes] [acyl-carrier-protein] [acyl-carrier-protein] [+ 11 isozymes] sthA [+ 2 isozymes] decarboxylase: hemE ACAA2 UDP-sugar [+ 2 isozymes] [+ 3 isozymes] [+ 6 isozymes] ribosyltransferase- a 1- [+ 4 isozymes] phosphate CDP-choline Bdh1 1: ansA fol1: fol1 [+ 2 isozymes] Probable CDP- 1D-myo- saturated MTRR hydrolase HADHA GabD: gabD Nsdhl 2, chloroplastic: Z: rnz [+ 5 isozymes] dehydratase: fabZ dehydratase: fabZ [+ 5 isozymes] pyrophosphorylase isomerase: queA phosphatidyl- a triacylglycerol Ethanolamine- synthase: cfa [+ 4 isozymes] shuttle Os07g0147900 ureidoglycolate I a non diacylglycerol--glycerol- a long-chain fatty 2: EPHX2 [+ 2 isozymes] histone TYRAAT2 RNase III 1: USP1 a 3’-terminal 1D-myo- a 1- inositol 3,5- phosphate Cyclopropane- 15-cis- 6-hydroxymethyl- nicotine- 2-aminomalonate- glucosylated beta-D- a single- benzoyl- an O- a 2-hydroxy Phosphatidylglycerophosphatase acyl CoA (urea producing) urea a trans- processing acetyl-CoA UDP 3-phosphate 3- inositol 3,4- phosphatidyl- bisphosphate fatty acid cytidylyltransferase: fatty-acyl- D-myo- camptothecin dihydroxyacetone phytoene a [methionine dihydropterin a ketone an aldehyde campest-4- 1’-N-oxide N6-methyl- semialdehyde a single- D-ribulose- glucose glucose a phosphoprotein acetaldehyde UQH2 a standard a trans- a peptide a peptide stranded coproporphyrinogen I CoA glutathione a 5’-phosphopolynucleotide unsaturated GEP4, mitochondrial: GEP4 Cholinephosphotransferase myo-inositol asp delta2- asp NADP+ product glucosylsterol carboxylate epoxyqueuosine phosphatidyltransferase: bisphosphate 1D-myo- Acyl-coenzyme phospholipid NADPH S-allantoin synthase]- diphosphate 15,16- OPC6-3- succinate L-lysine stranded 5-phosphate alpha tetracos-2- NADH RNA a UDP-sugar sugar pctA 1: Chpt1 inositol (1,4,5) biosynthesis acetoacetate phosphate en-3-one keto- acceptor mRNA at position 34 of a adenine pgs1 inositol 4,5- A thioesterase synthase: cfa biosynthesis cob(II)alamin dihydroxyoctadeca- ketoacyl- RNA decenoyl- amino acid enoyl-[acp] met Putative -trisphosphate phenylpyruvate [acp] tRNA containing [+ 2 isozymes] bisphosphate an L-1-phosphatidyl- CDP- 9, mitochondrial: 1,3-bisphospho- Urease: ure1 9,12-dienoate CoA long-chain- ethanolamine NADP-dependent GUN anticodon glycerol fatty-acid-- Acot9 a phosphatidylcholine a phospholipid biosynthesis D-glucose- Succinyl- D-glycerate cyclopropane trp 6-phosphate glyceraldehyde- an L-1- CoA ligase: loganin CoA:3-ketoacid- fatty acid myo-inositol 3-phosphate phosphatidylglycerol- HI_0002 a 2,3,4- coenzyme A Glycerol-3- Glycerol-3- Probable cardiolipin dehydrogenase: GPN1 ammonia a 5’-(N7- RNase E a non- N-6- phosphate Putative saturated coenzyme A Phospholipase transferase 1, phosphate phosphate 9,10- OPC4-3- N-(5’- 2-trans,5-cis- N-acetyl-L- UDP-alpha- an L-1- 1-phosphatidyl- synthase 1: crls-1 Glucose-6- [+ 3 isozymes] INORGANIC NUTRIENTS METABOLISM carbonic a primary succinate methylguanosine degradation 6-phospho- 1D-myo- an (R)-3- mitochondrial a reduced an organic a [protein]- a DNA UDP-D- glucuronosylated S-sulfanyl- isopentyl acyl-CoA fatty acid D p2: PLDP2 mitochondrial: dehydrogenase, dehydrogenase allantoate an alcohol big epoxyoctadeca- hydroxyacyl- phytyl a beta-lactam phosphoribosyl) tetradecadienoyl- homogentisate chlorophyllide a glutamate 5- a primary L-ascorbate violaxanthin folate a polypeptide pimeloyl- a diacylglycerol N-acetyl-D- phosphatidyl- 1D-myo- CDP-diacylglycerol- phosphate acid alcohol semialdehyde 5’-triphospho) substrate D-gluconate inositol (1)- hydroxyhexanoyl- intermediate cytochrome hydroperoxide L-cysteine ala with uracil glucuronate glucuronoside [acceptor] adenosine- Phosphatidylglycerophosphatase synthetase an L-1- -inositol 3- OXCT1 mitochondrial: [NAD(P)+]: gpsA endothelin 12,15-dienoate CoA diphosphate CoA semialdehyde alcohol CoA glucosamine inositol inositol 3,4,5- isomerase, -anthranilate -mRNA mRNA monophosphate [acp] protein c550 acceptor 37 tRNA GEP4, mitochondrial: GEP4 YngI: yngI phosphatidyl- phosphatidyltransferase inositol pyrophosphates biosynthesis GPD2 [+ 2 isozymes] Phosphoglycerate trisphosphate a cardiolipin cytosolic 1: PGIC1 D-myo- ethanolamine choline kinase, Allantoicase: Carbonyl Putative Epoxide Alcohol Succinate- Tryptophan Putative Enoyl-CoA delta Homogentisate Probable 3- Peroxiredoxin- Violaxanthin Putative Phosphatidylinositol N- 1: PIS1 Inositol-3- inositol (1,3,4) Trifunctional Geranylgeranyl Putative Ribonuclease H2 Pheophorbide Aspartate- Glutamate Putative dipeptidyl Uracil-DNA Hormone- (Dimethylallyl) secologanin tryptamine acetoacetyl-CoA chloroplastic: PGK D-glyceraldehyde- superpathway urea cycle allc reductase Endothelin- carbonic hydrolase enzyme dehydrogenase: semialdehyde uncharacterized biosynthesis uncharacterized isomerase 2, 1,2-dioxygenase: subunit A putative: hydroxyisobutyrate Putative inositol a oxygenase, (3R)- Mitochondrial Alcohol 1: PRDX1 de-epoxidase, 8-amino-7- sensitive uncharacterized acetylglucosaminyltransferase an L-1-phosphatidyl- a long-chain D-myo-inositol phosphate 3-phospho-D-glycerate diphosphate monophosphatase semialdehyde carboxypeptidase peptidase IV: glycosylase: adenosine tRNA an L-1- -trisphosphate [+ 3 isozymes] 3-phosphate Allantoicase: [NADPH] converting anhydrase 4: Ephx4 subunit alpha, gbsB dehydrogenase protein: protein protein: mitochondrial: hmgA AlNc14C123G6738 dehydrogenase, chloroplastic: hydroxymyristoyl- intermediate dehydrogenase: Maleylacetate chloroplastic: oxononanoate ung lipase: LIPE protein: subunit Q: PIGQ glycerol acyl-CoA (1,3,4,5,6)- synthase: ino1 of ammonia sulfide reductase: chlP 3: GA13929 dehydrogenase: asd 2: FOLH1 Esi_0282_0006 methylthiotransferase phosphatidyl- biosynthesis allc COFACTORS, 1: Cbr1 enzyme 3: cah-3 Epoxide mitochondrial: [+ 7 isozymes] [NADP(+)] PB2503_10024 TRP1: TRP1 CAOG_03223 Eci2 Homogentisate Ribonuclease mitochondrial: hibA PAO [+ 2 isozymes] [acyl-carrier-protein] peptidase: gbsB reductase VDE1 synthase: bioF Hormone- PITG_05764 [+ 2 isozymes] pentakisphosphate sn-glycerol- assimilation [+ 3 isozymes] MiaB: miaB inositol D-myo-inositol 3-ketoacyl- oxidation PROSTHETIC GROUPS, 2: ECE2 [+ 4 isozymes] hydrolase HADHA all-trans- GabD: gabD [+ 8 isozymes] 1-(o- 1,2-dioxygenase: Z: rnz [+ 5 isozymes] [+ 2 isozymes] dehydratase: fabZ MIPEP [+ 2 isozymes] 1: macA [+ 3 isozymes] an AP(apurinic sensitive Adipocyte 1D-myo- 3-phosphate capped a 6-(N-acetyl-D- (1,3,4,5)- CoA thiolase Ribulose bisphosphate (plants) arg I (sulfide- S-(-)- 2: EPHX2 [+ 2 isozymes] geranyl- carboxyphenylamino) 3,5- hmgA or apyrimidinic) lipase: LIPE a glucuronosylated plasma membrane- D-sedoheptulose- Triosephosphate ELECTRON CARRIERS mRNA a glutamate N-terminal 7-keto-8- glucosaminyl)- Phosphatidylinositol Inositol- inositol (3)- tetrakisphosphate B, peroxisomal: carboxylase a ketone an aldehyde geranyl a substituted tetradecadienoyl- a single- N-acetylglutamyl- pteroate a peptide coenzyme A site created uracil glucuronoside UDP UDP 2-methylthio- associated monophosphate 1,7-bisphosphate isomerase: tpiA ammonia quinone ureidoglycolate -1’-deoxyribulose- with cap D-ribulose- a trans a reduced a protein L-dehydro- dipeptide aminopelargonate 1-phosphatidyl- 4-kinase beta pentakisphosphate Acaa1b large chain: rbcL DEGRADATION CO2 9,10- OPC4-3- succinate beta- CoA stranded myo-inositol 71-hydroxychlorophyllide a phosphate N-terminal mature an alcohol antheraxanthin acceptor N-6- an protein: APMAP [+ 2 isozymes] endothelin 1 diphosphate 5’-phosphate I structure 4-maleyl- 5-phosphate hex-2- an aldehyde cytochrome disulfide ascorbate by glycosylic 1D-myo-inositol reductase) dihydroxyoctadeca- amino acid octapeptide protein a monoacylglycerol isopentyl 5’-deoxyadenosine unsulfurated 1: PI4KBETA1 2-kinase: IPK1 Probable hydrogen ketoacyl- acetoacetate RNA enoyl-[acp] c550 bond cleavage a carboxylate met NUCLEOSIDES AND NUCLEOTIDES BIOSYNTHESIS [+ 3 isozymes] Putative inositol acetyl-CoA cyanate sulfide heme 12,15-dienoate CoA adenosine- sulfur acceptor purine nucleotides de a diphospho- monophosphatase Inositol acetyltransferase, Glutamine ammonia 37 tRNA a 1- 1D-myo-inositol D-ribulose-1,5- dihydroxyacetone degradation degradation pyrimidine ribonucleotides de novo biosynthesis strictosidine 1D-myo-inositol 3: GA13929 polyphosphate cytosolic 2: CO2 synthetase Arginase- novo biosynthesis II adenine and phosphatidyl- 1,2,3,4,5,6- multikinase: IPMK bisphosphate phosphate tetrakisphosphate [+ 3 isozymes] At5g47720 leaf isozyme, Argininosuccinate 1: Arg1 Sulfide:quinone adenosine 1D-myo- a 1- hexakisphosphate D-myo- D-myo- D-sedoheptulose- oxidoreductase, 5-phospho- chloroplastic: GS2 lyase: ASL Carbamoyl- ammonia protoheme IX a protein epoxyqueuosine a protein N-acetyl- alpha-D- salvage VI inositol 4- phosphatidyl- inositol (1,3,4) inositol (1,4,5) 7-phosphate Type-1 glutamine mitochondrial: 12,13- beta-D- a 1,3-beta- UDP-D- bicarbonate Phosphatidylinositol- 1D-myo- Argininosuccinate phosphate with all-trans- (6E)-8- an organic at position 34 of a c-terminal a guanine10 an (R)-3- gamma- UTP beta-D- ribose 1- phosphate -trisphosphate -trisphosphate Probable ribose- Fructose-bisphosphate synthetase sqrdl lathosterol XMP epoxyoctadeca- zeaxanthin pregnenolone D-glucan a steryl-ester 71-hydroxychlorophyllide a dehydroepiandrosterone an oxidized a primary a reduced glutamate-1- 2-oxoglutarate an RNA a pimelyl- a 1-lysophosphatidylcholine galactose an RNA NAD+ (deoxynucleotides)(m) a deoxyribonucleotide 4-phosphate 5- myo-inositol acetyl-CoA lyase: ASL synthase CO2 incorrect retinol cys oxogeraniol hydroperoxide fructose 2,6- tRNA containing S-farnesyl- in tRNA hydroxydecanoyl- a protein nitrate tRNAGlu 2-oxoglutarate pro butyrobetaine ala glucosamine inositol 5- Phosphoribulokinase,5-phosphate aldolase, chloroplastic: L-arginino- Sulfide:quinone 9,15-dienoate azurin alcohol cytochrome semialdehyde [acp] diphosphate adenosine Transketolase: TKL1 1: glnA1 L-ornithine[ammonia], Heme disulfide bisphosphate GUN anticodon L-cysteine [acp] kinase its3: its3 phosphate chloroplastic:isomerase: PRKA At2g01290 Os11g0171300 oxidoreductase, [+ 4 isozymes] Transketolase: tkt-1 succinate mitochondrial: oxygenase bonds Probable Amidophosphoribosyltransferase: purF strictosamide Probable ribose- [+ 3 isozymes] Putative mitochondrial: Emopamil- Cytosolic 5’- Epoxide Retinol Alcohol Zeaxanthin Peroxiredoxin- Sterol-4-alpha- Hormone- tRNA Pheophorbide Sterol-4-alpha- Probable Terminal Neuropathy Beta-1,4- Polyribonucleotide Cps1 1: HMOX1 Fructose-2,6- glucan Protein-S- DNA ligase (Fragment): Amidophosphoribosyltransferase: purF 1-diphospho- 5-diphospho- 3-diphospho- 5-phosphate carbonic hmt2 binding Protein nucleotidase hydrolase dehydrogenase Cysteine dehydrogenase: epoxidase, 1: PRDX1 carboxylate 3- sensitive Epoxyqueuosine (guanine(10)-N2)- a oxygenase, carboxylate 3- (3R)- Protein Alcohol Nitrate reductase Glutamyl- Prolyl 4- gamma- uridylyltransferase 8-amino-7- target galactosyltransferase nucleotidyltransferase: pnp bisphosphatase: 1,3-beta- isoprenylcysteine O- GSTENG00019603001 1D-myo-inositol 1D-myo-inositol 1D-myo-inositol isomerase: At2g01290 gln Argininosuccinate anhydrase protein- disulfide- 3: nt5c3 4: Ephx4 11: RDH11 dioxygenase: adh chloroplastic: Maleylacetate dehydrogenase, lipase: LIPE methyltransferase chloroplastic: dehydrogenase, hydroxymyristoyl- disulfide- dehydrogenase: [NADH], clone tRNA hydroxylase butyrobetaine 7: Zcchc6 oxononanoate esterase: 3: B4GALT3 Polyribonucleotide 5-phospho- Adenosine D-ribulose-5-phosphate D-ribose-5-phosphate fructose-1,6- FBP26 glucosidase reductase: queG methyltransferase: DNA (2,3,4,5,6) (1,2,3,4,6) (1,2,4,5,6) bisphosphate synthase: argG carbamoyl- 3: cah-3 biliverdin- like: Ebpl isomerase Cytosolic 5’- Epoxide Retinol CDO1 [+ 7 isozymes] ZEP reductase decarboxylating: Hormone- homolog: trmt11 PAO decarboxylating: [acyl-carrier-protein] isomerase gbsB PBNBR1412: reductase: subunit dioxygenase: [+ 28 isozymes] synthase: bioF Pnpla6 nucleotidyltransferase: pnp beta-D- carbamoyl- kinase AMINOACYL- intracellular A: exgA queuosine at ICMT ligase: ligA a 1- pentakisphosphate pentakisphosphate pentakisphosphate Fructose-1,6- phosphate [+ 4 isozymes] IX-alpha A3: Pdia3 nucleotidase hydrolase dehydrogenase [+ 2 isozymes] 1: macA [+ 2 isozymes] Nsdhl sensitive [+ 2 isozymes] [+ 2 isozymes] Nsdhl dehydratase: fabZ A3: Pdia3 [+ 2 isozymes] NIA2 hemA alpha: phyA mll1440 Lysophospholipase beta-D- ribosyl- phosphate 1: ADK1 bisphosphatase, S0 position 34 phosphatidyl- TRNA CHARGING III: NT5C3 2: EPHX2 14: RDH14 lipase: LIPE a protein 2: plb2 galactosyl- amine Ribulose-phosphate chloroplastic: FBP Ornithine (6E)-8- of a tRNA 1D-myo- Glutamate zymostenol a protein D-fructose- pregn-5- alpha-D- a 1,3-beta- c-terminal an N2- a trans- trans-4- an RNA 7-keto-8- 1,4-N-acetyl- UDP a nucleoside 3-epimerase: rpe Ferredoxin- carbamoyltransferase: Cyanate bicarbonate 3-sulfinoalanine oxogeranial containing 5-androstene- a holo-[acp] an RNA Trifunctional inositol 4,5- [+ 7 isozymes] synthase carbamate with correct 12,13- antheraxanthin an alcohol 6-phosphate ene-3,20- glucose D-glucan s-farnesyl- methylguanine10 chlorophyllide b delta2- a reduced an oxidized L-glutamyl- hydroxy- succinate L-carnitine succinate aminopelargonate beta-D- diphosphate Protein camptothecin Ribulose-phosphate dependent argF hydratase: GUN 3,17-dione a peptide a peptide an aldehyde nitrite purine bisphosphate tRNA charging 1 [NADH], disulfide xanthosine dihydroxyoctadeca- all-trans- dione a fatty acid a sterol l-cysteine in tRNA decenoyl- azurin cytochrome tRNAGlu L-proline a carboxylate L-1-glycero-3- glucosamine nicotinamide AMP adenosine PYR1- AMP 3-epimerase: RPE glutamate CYN retinal anticodon phosphocholine a deoxyribonucleotide biosynthetic chloroplastic: bonds 9,15-dienoate methyl ester [acp] mononucleotide nucleotides de 3: pyr1-3 Arginine- synthase 2: gltS protein 1,5-bisdiphosphoinositol-3,5-bisdiphosphoinositol- GLT1 L-citrulline -tRNA adenosine- novo biosynthesis 1D-myo-inositol (2,3,4,6) superpathway of glyoxylate [+ 3 isozymes] [+ 3 isozymes] bilirubin 1D-myo-inositol (2,3,4,6) ligase: argS cyanate 3: Gart CTP tetrakisphosphate tetrakisphosphate arg cycle and fatty acid degradation D-xylulose-5-phosphate D-fructose-6-phosphate CO2 N-carbamoyl- synthase: Arginine- sulfite oxidation Bifunctional D-myo- glt a beta-D- UDP-N- L-aspartate URA7 -tRNA D-erythro- a tRNA a methylated purine IMP inositol (1,4,5) a 2,3,4-saturated I (sulfite a sphinganine a long-chain a [protein]-L- 5-amino- glucan 5’,5’’’- 5,6- an alpha-D- a (R)-3- an (R)-3- a RNA- a standard a (5-L- 6-hydroxymethyl- acetylmuramoyl- [+ 2 isozymes] -trisphosphate ligase: argS L-arginyl- zymosterol isoliquiritigenin a polypeptide sitosterol a ribonucleoside imidazole- H2O a [protein]- an oxidized a primary 9S rRNA precursor nucleobase biosynthetic fatty acid oxidoreductase) (C18) levulinate with a C3- a histone diadenosine dihydrouracil47 galactoside hydroxystearoyl- a protein a ubiquitin a protein alpha glutamyl)- dihydropterin 4-aminobenzoate 2-oxoglutarate ditrans,octacis- L-alanyl-D- UTP CTP tRNAarg acyl-CoA methionine diphosphate glycerol- ATP hydroxypalmitoyl- L-lysine cytochrome cL alcohol with a 5’ DNA hybrid ATP within DNA protein substituted FMN tetraphosphate in tRNA cobinamide diphosphate glutamyl- Dihydroorotase: Nucleoside phosphate [acp] [acp] extension amino acid L-peptide undecaprenyl purD: purD diphosphate tRNAarg sulfite glucose Alpha- phosphate meso-2,6- pyrC ABC OTHER BIOSYNTHESIS Putative long-chain- Transketolase: TKL1 Emopamil- Ceramide Chalcone Putative Peptide Putative Sterol-4-alpha- Delta- Probable manganese- Ribonuclease H2 Uncharacterized Alkylated Adenylosuccinate Soluble Soluble sulfite Nucleoside Imidazoleglycerol- galactosidase: Folic acid diaminopimelyl-D- kinase 4, transporter fatty-acid--CoA Transketolase: tkt-1 phosphate binding synthase Isomerase: fatty acid methionine carboxylate 3- aminolevulinic Endo- Histone tRNA- dependent inorganic (3R)- (3R)- Serine Ubiquitin- Puromycin- Alcohol subunit A putative: Ribonuclease H2 Putative gamma- DNA repair 5-phospho- synthetase: calcium- ABC calcium- serine diphosphate phosphate Bis(5’-nucleosyl)- rafA protein Mb2253c: synthesis alanyl-D-alanine chloroplastic:ATP-binding Nucleoside oxidation IV protein- dehydrogenase, acid acetyltransferase dihydrouridine(47) hydroxymyristoyl- hydroxymyristoyl- protease activating sensitive dehydrogenase: glutamyltransferase protein alkB ribosyl- PITG_16736 (S)- activated ligase: HI_0002 utilization 4: CERS4 CHI elongation sulfoxide protease 1,3(4)-beta- FAD tetraphosphatase, pyrophosphatase: AlNc14C123G6738 subunit A putative: Mb2253c Cob(I)yrinic protein NDK4 protein/ activated diphosphate transporter thiosulfate Sulfite oxidase, kinase: swoH dehydratase: HIS3 synthase Alpha- aminopeptidase: glycineamide dihydroorotate ATP-binding nucleotidase [+ 2 isozymes] like: Ebpl Ceramide Similar to protein reductase HhoA: hhoA decarboxylating: dehydratase, glucanase GCN5: GCN5 synthase: symmetrical: apaH ppaC [acyl-carrier-protein] [acyl-carrier-protein] 23: Prss23 enzyme gbsB Ribonuclease AlNc14C123G6738 [+ 2 isozymes] ywrD: ywrD acid a,c-diamide homolog UDP-N-acetylglucosamine- [+ 2 isozymes]permease nucleotidase kinase 4, in cell wall disproportionation mitochondrial: Nsdhl [+ 2 isozymes] chloroplastic: galactosidase: dehydratase: fabZ [+ 2 isozymes] E1 1: ptr3 Npepps [+ 2 isozymes] Z: rnz [+ 2 isozymes] fol1: fol1 1: Cant1 plant sterol 5alpha- synthase Chalcone 3: elo-3 A3: MSRA3 [+ 2 isozymes] 1: eng1 [+ 4 isozymes] flad1 [NAD(P)(+)]: dus3 [+ 6 isozymes] dehydratase: fabZ adenosyltransferase, 8: ALKBH8 -dolichyl-phosphate N- wht-1: wht-1 1: Cant1 chloroplastic: protein/ sulfite Suox imidazole Os10g0493600 L-dopachrome Cysteine-- regeneration III (rhodanese) 6: CERS6 Isomerase: [+ 3 isozymes] [+ 6 isozymes] HEMB [+ 2 isozymes] [+ 22 isozymes] mitochondrial: Mmab acetylglucosaminephosphotransferase: Bifunctional adenylo- Dihydroorotate [+ 126 isozymes] permease biosynthesis a 2,3,4-saturated Probable cholesta- 3-oxo- acetol- a 5-L- NDK4 PENTOSE PHOSPHATE PATHWAYS CHI a beta- a beta- a single- a nucleoside 7,8- DPAGT1 purine wht-1: wht-1 biosynthesis tRNA ligase, fatty acyl CoA a phosphate sulfite oxidase, 7,24-dien- 24-ethyl- a ribonucleoside an uracil47 a trans- a trans an a single- a DNA glutamyl-L- a peptide a nucleobase succinate dehydrogenase [+ 2 isozymes] CMP a protein-L- a polypeptide phosphate H+ alpha-D- an organic a protein- N-terminal a reduced 5S rRNA stranded dihydropteroate formaldehyde succinate biosynthetic UDP UMP [+ 126 isozymes] cytoplasmic: monoester Sulfite oxidase, thiosulfate mitochondrial: 3beta-ol a plant a long-chain cholest- triphosphate D glucan D glucan acetylated ADP octadec-2- hexadecenoyl- a peptide a peptide a peptide an aldehyde uncharged stranded monophosphate amino acid within DNA N-acetylmuramoyl-L- (quinone), (2E,6E)- methionine- porphobilinogen in tRNA galactose molecule amino acid cytochrome cL RNA adenosylcobinamide PPPi protein Uridylate cys cysS mitochondrial: CG7280 ceramide (I) acyl-CoA 5-ene histone FAD enoyl-[acp] [acp] N-ubiquityl- tRNA RNA mitochondrial: CDP farnesyl Putative peroxisomal liquiritigenin (S)-S-oxide lysine alanyl-D-glutamyl-meso- purD: purD kinase: tyr Cysteine- Suox 2,6-diaminopimelyl- UMP Dhodh tRNA methylation (yeast) diphosphate acyl-coenzyme A pentose phosphate Purple acid Adenylosuccinate URA6 -tRNA Probable Probable D-alanyl-D-alanine- lyase: ADSL 5-phospho- ligase: cysS L-cysteinyl- oxidase 1.2: ACX1.2 pathway (partial) phosphatase adenylyltransferase/ 5’-phosphoribosyl- Squalene sulfite oxidase, sulfate diphosphoundecaprenol alpha-D- a cytidine32/ tRNAcys Peroxisomal 7: PAP7 sulfurtransferase N-formylglycineamide orotate a guanine26 a cytosine49 a cytosine48 a carboxymethyluridine34 a guanine10 a uridine44 adenine58 synthase: [+ 12 isozymes] mitochondrial: ribose 1- a cytosine40 in a cytosine34 in guanosine34 a cytidine4 a cytidine4 in an adenosine4 Tyrosinase: acyl-coenzyme A D-ribulose- CG7280 MoeZ: moeZ diphosphate Orotate in tRNA in tRNA in tRNA in tRNA in tRNA in tRNAser in tRNA fdfT tRNAcys oxidase 1: Acox1 [+ 4 isozymes] dTDP- 4-(cytidine 5’- RNase (1S,2R) tRNA precursor tRNA precursor in tRNA in tRNAPro tRNAGly(GCC) in tRNAHis melC2 5-phosphate all-trans- a reduced 2-[(1R,6S)-1,6- (S)- Probable phosphoribosyltransferase: pyrE a [protein]-L- indole alpha-L- 3-hydroxyadipyl- 5’,5’’’- 5,6- uridine2552 diphospho) a (R)-3- a (R)-3- a (R)-3- E mRNA -1-C- alpha- AMP geranyl- a chalcone linoleate an alcohol kynurenine demethylmenaquinone-7 chlorophyllide a electron- crotonyl- a triacylglycerol a 2-oxo adenosylcobinamide- coenzyme A dihydroxycyclohexa- an RNA NAD+ coenzyme A methylmalonate- Orotate a holo-[acp] methionine acetaldehyde rhamnose CoA a protein a phosphorylase a diadenosine dihydrouracil17 in 23S rRNA -2-C-methyl- hydroxycerotoyl- hydroxyarachidoyl- hydroxydodecanoyl- processing L-ornithine ser (indol-3-yl) ribazole-5’- phosphoribosylformylglycinamidine tRNA (guanine(26) tRNA (cytosine(49) tRNA presqualene phosphate sulfate geranyl a thiopurine transfer CoA GDP 2,4-dien-1-yl]acetyl-coA semialdehyde phosphoribosyltransferase: pyrE tRNA (cytosine(34) tRNA guanosine-2’- tRNA guanosine-2’- tRNA guanosine-2’- dopaquinone a trans-2-enoyl-CoA Ribulose- sulfite thiocyanate triphosphate in tRNA D-erythritol [acp] [acp] [acp] substrate carboxylate glycerol 3- phosphate synthase, chloroplastic/ -N(2))- -C(5))- (guanine(10)-N2)- diphosphate diphosphate flavoprotein mitochondrial: At1g74260 -C(5))- O-methyltransferase O-methyltransferase O-methyltransferase phosphate Probable phosphate methyltransferase Similar to Fatty acid Alcohol Kynurenine 3- Putative Methylmalonate dimethyltransferase: methyltransferase: methyltransferase: a 2’-O- TRM13 homolog: TRM13 homolog: TRM13 homolog: 3-epimerase: Phytoene Peptide Alcohol rhamnose Trifunctional Ribosomal RNA 4-diphosphocytidyl- Ubiquinone/ Protochlorophyllide Ribonuclease H2 Hormone- Ribonuclease H2 Adenylate Trmt1 PYRAB06230 a 5-(2-methoxy- homolog: trmt11 a 2’-O- N1- phosphate Chalcone desaturase Malonyl CoA- methionine dehydrogenase dehydrogenase enzyme Protein monooxygenase, Phosphorylase Bis(5’-adenosyl) tRNA- large subunit (3R)- (3R)- menaquinone reductase, (3R)- Acyl-coenzyme A subunit A putative: sensitive Ornithine Tryptophan Cobalamin enoyl-CoA subunit A putative: semialdehyde orotidine-5’- a 5-methylcytosine48 nsun2 methylcytidine32/2-O- CCDC76 CCDC76 CCDC76 Probable enoyl- rpe ammonium synthase: biosynthetic 2-C-methyl- 5-phosphoribosyl-N- kinase: adk 2-oxoethyl) [+ 2 isozymes] methyluridine44 methyladenine58 Squalene Probable Ribulose- acquisition Isomerase: 2: fads2 acyl carrier sulfoxide [NADP(+) [NADP(+) subunit alpha, kinase C: putative: kmo phosphatase, Probable thiol -triphosphatase: dihydrouridine(16/ methyltransferase hydroxymyristoyl- hydroxymyristoyl- biosynthesis chloroplastic: PORA hydroxymyristoyl- dehydrogenase: AlNc14C123G6738 lipase: LIPE aminotransferase, synthase: synthase: hydratase/ AlNc14C123G6738 dehydrogenase phosphate in tRNA a 5 methylcytosine40 methylguanosine34 synthase: gln CoA hydratase, transport crtB enzyme D-erythritol formylglycineamidine GTP:AMP an N2- uridine34 in tRNA in tRNAser in tRNA glutamine- phosphate CHI Fatty acid protein reductase ]: Akr1a1 ]: Akr1a1 mitochondrial: Pkc98E Kynurenine 3- putative: methyltransferase fhit 17) synthase E: rlmE [acyl-carrier-protein] [acyl-carrier-protein] methyltransferase Protochlorophyllide [acyl-carrier-protein] fadE Ribonuclease Hormone- mitochondrial: Oat TRP-1 cobS isomerase Ribonuclease [acylating] 1: iolA1 a 5-methylcytosine49 in tRNA precursor in tRNA a 2’-O- mitochondrial: echs1 1: RHM1 kinase: ispE phosphotransferase, methylguanine26 an N2- a 2’-O- a 2’-O- fdfT Chalcone desaturase transacylase: A3: MSRA3 [+ 4 isozymes] [+ 2 isozymes] HADHA [+ 2 isozymes] monooxygenase: IMG5_051480 2: HOL3 [NAD(P)(+)]: DUS1 [+ 5 isozymes] dehydratase: fabZ dehydratase: fabZ ubiE: ubiE reductase A, dehydratase: fabZ [+ 8 isozymes] sensitive yngF: yngF Probable in tRNA a 5 methylcytosine34 -tRNA 3-epimerase: [+ 4 isozymes] Z: rnz Z: rnz mitochondrial: AK3 methylcytidine4 methylcytidine4 methyladenosine4 a phosphate Isomerase: fabD [+ 2 isozymes] 2-phospho- methylmalonate- Phosphoribosylformylglycinamidine in tRNA in tRNA precursor methylguanine10 ligase: glnS L-glutaminyl- RPE ammonium prephytoene family protein: [+ 5 isozymes] BNA4 [+ 3 isozymes] chloroplastic: PORA lipase: LIPE a standard L-glutamate in tRNA in tRNAPro in tRNAGly(GCC) in tRNAHis a (3S)-3- CARBOHYDRATES DEGRADATION monoester CHI dTDP-4- 4-(cytidine 5’- an oxidized RNase E D-glyceraldehyde- semialdehyde cyclo-ligase: purM leucodopachrome tRNAgln diphosphate Bm1_38160 indole-3- 2-O- a trans- a trans- a trans a single- alpha gamma- trp 3-hydroxyadipyl- squalene hydroxyacyl-CoA a protein-L- an aldehyde dehydro-6- uracil17 methyluridine2552 diphospho) butanoyl- electron- processing 3-phosphate adenosylcobalamin acetyl-CoA a nucleoside dehydrogenase tRNA (guanine(26) D-xylulose- D-erythrose- ethanol a phosphoprotein 3-hydroxy- a phosphorylase b a thiopurine AMP ADP in tRNA hexacos-2- eicos-2- monovinyl dodec-2- stranded amino acid semialdehyde GMP CoA a 3’ phosphooligonucleotide Phosphoribosylformylglycinamidine tRNAgln a malonyl- methionine- deoxy-beta- 3-oxoadipyl- in 23S rRNA -2-C-methyl- menaquinone-7 CoA transfer product a diacylglycerol a carboxylate 5’-phosphate 3’-phosphate [acylating], cyclo-ligase: purM -N(2))- 4-phosphate Purple acid Ammonium gamma- CoA L-kynurenine S-methylether enoyl-[acp] enoyl-[acp] protochlorophyllide a enoyl-[acp] RNA ADP 5-phosphate a flavanone [acp] (R)-S-oxide L-mannose D-erythritol flavoprotein mRNA mitochondrial: tRNA dimethyltransferase: Trifunctional enzyme phosphatase transporter linolenate 5-amino- Squalene Transketolase: Transketolase: xylose degradation IV mmsdh splicing Trmt1 subunit alpha, TKL1 TKL1 7: PAP7 NrgA: nrgA 1-(5- guanine and monooxygenase: mitochondrial: HADHA Transketolase: Transketolase: trehalose [+ 12 isozymes] phospho- guanosine Sqle beta-D- [+ 2 isozymes] tkt-1 degradation propanoyl- D-ribosyl) a polycistronic an N2dimethylguanine26 CARBOHYDRATES BIOSYNTHESIS tkt-1 glucose-6- NADH ATP salvage I L-dopachrome Glutamate-- ammonium CoA imidazole tRNA precursor in tRNA dolichyl- (3S)-2,3- phosphate II (trehalase) synthase gluconeogenesis I callose epoxy-2,3- tRNA ligase, phosphate subunit Phosphoribosylaminoimidazole Ribonucleoside- guanosine diphosphooligosaccharide dihydrosqualene chloroplastic/ a 3-oxoacyl-CoA trehalose diphosphate biosynthesis Glucose-6- carboxylase: ade6 a: ATP6 mitochondrial: biosynthesis phosphate 1- 22-hydroxy- a 3beta- 2-phospho- N-acetyl-beta- reductase large [+ 15 isozymes] tRNA-splicing At5g64050 D-glyceraldehyde- DETOXIFICATION 4-(2’- an oxidized a 2,3,4- 3-amino-3- 5-amino-1- (S)-malate a 1,3-beta- Cycloartenol dehydrogenase, pinocembrin 3-oxochol- hydroxy- (+)- peptidylproline 5,6- D-ribulose- an (R)-3- N-substituted phosphoribulosylformimino- D-glyceraldehyde- aminocarboxymuconate 4-(cytidine 5’- 1D-myo- UDP-alpha- 5,10- D-glucosaminyl- subunit: RNR1 endonuclease Bifunctional 3-phosphate Trehalase: sphingosine oleate a polypeptide carboxyphenyl)- a chitodextrin an aldehyde a chitodextrin raffinose L-arginyl- electron- saturated pyruvate D-ribose-5- deoxy-D- dUMP a dolichyl D-glucan synthase: CAS glt 3-ketoacyl-CoA thiolase, cytoplasmic chalcone 4-en-24- delta5- neomenthol (omega = 180) dihydrouracil16 5-phosphate hydroxybutanoyl- aminoacyl- a protein a protein a protein AICAR-P 3-phosphate semialdehyde phosphate diphospho) inositol (3)- N-acetyl-D- methylenetetrahydrofolate 1,2-alpha- (5-phospho- [+ 3 isozymes] subunit Purine nucleoside glutamate/ tre1 GTP 4-oxobutyryl-CoA ADP ATP tRNAarg transfer fatty fructose 6- D-ribosyl) phosphate Cycloartenol mitochondrial: ACAA2 isoform 1: ACG9 oyl-CoA steroid in tRNA [acp] tRNA -2-C-methyl- monophosphate glucosamine D-mannosyl- Sen34: Tsen34 phosphorylase 1: punA proline--tRNA Trehalase: flavoprotein acyl CoA phosphate imidazole-4- Callose synthase: cas1 GDH/6PGL Di-N- Di-N- Alpha- D-erythritol 1,3-(N-acetyl- dADP ATP Malate dehydrogenase, phytochelatins ligase: EPRS L-glutamyl- TREH Ceramide Similar to Fatty acid Trifunctional Sterol-4-alpha- 1,4- (+)-neomenthol Peptidyl- Probable aldehyde Riboflavin Imidazole Probable 2-amino-3- Bifunctional carboxylate a 5’ half- mitochondrial: MDH2 synthase endoplasmic superoxide Insulin- acetylchitobiase: acetylchitobiase: galactosidase: Transketolase: D-inositol-3- beta-D- a 3’ half- Dolichyl- NADP-dependent malic tRNAGlu a 2,3,4-saturated synthase Chalcone desaturase enzyme carboxylate 3- Dihydroxy- dehydrogenase: prolyl dehydrogenase: tRNA- biosynthesis (3R)- Peptidyl-tRNA Putative Arginyl- Proteasome Isovaleryl-CoA glycerol 1-deoxy-D- carboxymuconate- 2-C-methyl-D- dihydrofolate UDP-alpha- tRNA 7: CALS7 biosynthesis acetyl-CoA bifunctional lactose radicals glutamate arginine degrading CTBS CTBS rafA TKL1 phosphate glucosaminyl- Nucleoside tRNA phosphate beta- enzyme, mitochondrial: Me3 fatty acyl CoA beta-D- 4: CERS4 Isomerase: 2: fads2 GTPase subunit alpha, dehydrogenase, 2-naphthoyl- SDR1 cis-trans 5’,5’’’-P-1,P-4- FIS1 dihydrouridine(16/ protein ribBA, hydroxymyristoyl- hydrolase ICT1, serine tRNA-- subunit beta dehydrogenase, phosphate xylulose-5- 6-semialdehyde erythritol 2,4- reductase- N-acetyl-D- Phosphoribosylaminoimidazole- molecule cycloartenol tRNAGlu protein: H6PD dependent dependent enzyme: Ide Chitinase Chitinase Alpha- Transketolase: glycosyltransferase: 1,2-alpha- diphosphate molecule guanine NADP-dependent malic glucose degradation III degradation Ceramide CHI Fatty acid HflX: hflX mitochondrial: decarboxylating: CoA (+)-neomenthol isomerase tetraphosphate Aldehyde 17) synthase chloroplastic: [acyl-carrier-protein] mitochondrial: protease protein type-3: PBC1 mitochondrial: Ivd synthase hisHF, phosphate decarboxylase: acmsd cyclodiphosphate thymidylate glucosamine succinocarboxamide synthase: purC with a glucosyltransferase: a 1,3-beta- [+ 5 isozymes] domain- domain- galactosidase: tkt-1 mshA D-mannosyl- kinase: swoH with a ALG5 oxaloacetate enzyme, chloroplastic: MOD1 glutathione acid acid synthase Chalcone desaturase [+ 129 isozymes] HADHA Nsdhl synthase: dehydrogenase: D: PPID phosphorylase dehydrogenase [NAD(P)(+)]: DUS1 RIBBA dehydratase: fabZ ict1 HhoA: hhoA transferase [+ 27 isozymes] [+ 8 isozymes] chloroplastic: synthase, [+ 2 isozymes] synthase, synthase 2’,3’ cyclic a dolichyl D-glucan oxaloacetate 6-phospho- containing containing Os10g0493600 1,6)-beta-D- [+ 2 isozymes] hydroxyl an N- superoxide resistance resistance 6: CERS6 Isomerase: family protein: [+ 2 isozymes] menB SDR1 [+ 26 isozymes] 2: APA2 family 3 member [+ 2 isozymes] [+ 4 isozymes] 1: ATE1 At4g26900 chloroplastic: chloroplastic: ISPF 2: THY-2 5’-phosphoribosyl-4- phosphate beta-D- D-glucono- Glucokinase: lactose protein protein 1-deoxy- 1-O-(2-acetamido- mannosyl- on its 5’ end acetylglucosaminyl- Phosphoenolpyruvate pyruvate Citrate synthase, CHI Bm1_38160 a 3-oxo- H1: ALDH3H1 1-deoxy- a reduced CLA1 1-imino-D- (N-succinocarboxamide) on its 3’ end a dolichyl mannosyl superpathway of cytosolic glycolysis (plants) 1,5-lactone glcK 3,22- 1,4- 1: Chid1 1: Chid1 uracil16 2-aminomuconate D-sedoheptulose- 2-deoxy-alpha-D- 1,4-N-acetyl- Xanthine diphosphodolichol carboxykinase [ATP]: pckA Phosphoenolpyruvate glt a peptide delta5- alpha-D- L-glycero- a crotonyl- an N- a trans-2- electron- D-erythro- 2-C-methyl-D- -5-aminoimidazole beta-D- phosphate mitochondrial: cs arg dioxochol- dihydroxy- peptidylproline 5’,5’’’- in tRNA sucrose formate a peptide a peptide aminoimidazole semialdehyde erythrose 4- 7-phosphate glucopyranosyl) UDP 7,8-dihydrofolate beta-D- phosphoribosyltransferase: xpt Phosphoenolpyruvate carboxylase: ppc Glutathione gamma- , pyruvate dehydrogenase and TCA cycle Glucokinase: glk Beta- Superoxide a ceramide GDP steroid galactose tetrulose 4- [acp] a tRNA substituted a [protein]- enoyl-CoA transfer imidazole- 1-deoxy-D- erythritol-2,4- dTMP glucosyl Probable Probable 6- (2S)- 4-en-24- 2-naphthoyl- (-)-menthone (omega = 0) diadenosine a peptide a peptide tRNAarg carboxamide phosphate CMP -D-myo-inositol- monoglutamate glucosaminyl-R carboxykinase [ATP]: pckA glutamylcysteinyltransferase linoleate a carboxylate N,N’- amino acid L-arginine flavoprotein glycerol- xylulose 5- Adenylosuccinate [+ 2 isozymes] phosphate 24-methylenecycloartanol isoleucine-- galactosidase: dismutase CoA chitotriose tetraphosphate phosphate ribonucleotide cyclodiphosphate 3-phosphate colanic acid building blocks biosynthesis 1: PCS1 phosphogluconolactonase 4, beta-D- pinocembrin oyl-CoA diacetylchitobiose phosphate phosphate lyase: ADSL tRNA ligase, D-fructose-6-phosphate chloroplastic: Os09g0529100 glucose-6- lacZ [Cu-Zn]: Sod Glutathione gamma- [+ 4 isozymes] Glutamate Arginine Putative a 2’- cytoplasmic: phosphate dATP phospho- an (N- glutamylcysteinyltransferase Malate dehydrogenase, decarboxylase: decarboxylase: uncharacterized aminoimidazole ileS beta-D- beta-D- GMP acetylglucosaminyl) UTP beta-D-glucose- 1: PCS1 ile mitochondrial: MDH2 6-phospho- GAD speA protein [ligated alpha-D-galactose Isoleucine- galactose carboxamide 2-diphosphodolichol phosphoenolpyruvate 6-phosphate (S)-malate citrate 6-phosphofructokinase 3: PFK3 glucose hydrogen Glutamate B618R: B618R ribonucleotide tRNA] -tRNA Pyrophosphate--fructose 6- D-gluconate 4alpha- Pyrophosphate--fructose 6- peroxide decarboxylase: Beta-1,4-mannosyl- a poly gamma- ligase: ileS phosphate 1-phosphotransferase hydroxymethyl,4beta,14alpha- L-isoleucyl- subunit beta: PFP-BETA phosphate 1-phosphotransferase GAD agmatine glycoprotein 4-beta-N- Bifunctional glutamylcysteine- tRNAile Uncharacterized Enolase: PGH1 UTP--glucose- dimethyl-9beta,19-cyclo-5alpha- subunit beta: PFP-BETA acetylglucosaminyltransferase: purine Galactokinase: Glucose-6- glycine Malate synthase, Probable aconitate oxidoreductase Catalase: Enolase: PGH1 1-phosphate ergost-24(241)-en-3beta-ol tRNAile Mgat3 biosynthesis GALK1 phosphate glyoxysomal: acuE hydratase, ykwC: ykwC CAT a mannosyl-(N- Galactokinase: uridylyltransferase: [+ 2 isozymes] mitochondrial: aco2 4-aminobutyrate protein Ugp2 isomerase, fructose-1,6-bisphosphate [+ 5 isozymes] (1,4)-beta- PURH: ATIC an acetylglucosaminyl) GALK1 cytosolic 1: PGIC1 N-acetyl-beta- 2-diphosphodolichol Probable xylan uncharged ADP ribose 2-phospho-D-glycerate Glucose-6- O2 D-glucosaminyl- adenine and salvage pathways of pyrimidine ribonucleotides phosphoglucomutase, D-ribulose- phosphoribosyl- tRNA 1’’,2’’-cyclic phosphate 4alpha- degradation 1,2-alpha- adenosine alpha-D-galactose cytoplasmic acetyl-CoA glyoxylate cis-aconitate 5-phosphate a (1-> formamido- phosphate isomerase, formyl,4beta,14alpha- Fructose-bisphosphate aldolase, D-mannosyl- 2,3-bisphosphoglycerate- 1-phosphate 2: At1g70730 Probable aconitate carboxamide salvage II cytidine cytosolic: PGIC dimethyl-9beta,19- chloroplastic: Os11g0171300 4)-beta- 1,3-(N-acetyl- dependent phosphoglycerate cyclo-5alpha-ergost- PRPP hydratase, D-xylan beta-D- leu [+ 3 isozymes] Probable a (mannosyl)2-(N- mutase: gpmA 24(241)-en-3beta-ol biosynthesis I Leucine- mitochondrial: aco2 Ribulose- Bifunctional adenosine UDP-D-glucose Endo- glucosaminyl- acetylglucosaminyl) [+ 6 isozymes] D-fructose- -tRNA ribose-5- phosphate purine 1,4-beta- 1,2-alpha- 2-diphosphodolichol 6-phosphate ligase: leuS L-leucyl- phosphate 3-epimerase: C1 COMPOUNDS UTILIZATION AND ASSIMILATION D-mannosyl- UDP biosynthesis D-ribose-5- Isocitrate lyase: ACU-7 Triosephosphate isomerase: tpiA isomerase: rpe xylanase protein phosphate tRNAleu 1,6)-(N- [+ 2 isozymes] D-xylose At2g01290 Ribulose- B: xynB PURH: ATIC xanthine and 3-phospho-D-glycerate UDP-D-galactose 4alpha-carboxy- D-glyceraldehyde-3-phosphate acetyl-beta-D- cytosine uridine CMP Probable UDP- tRNAleu succinate dihydroxyacetone phosphate Probable phosphate ADP xanthosine glucose 6- Mannose-6- 4beta,14alpha- a (1->4)- glucosaminyl- Ribose-phosphate D-threo-isocitrate ribose-5- 3-epimerase: ribose 1’’- Cytosine dehydrogenase phosphate dimethyl- beta-D-xylan 1,4)-beta-D- salvage pyrophosphokinase Xylose phosphate RPE formaldehyde phosphate deaminase: a (mannosyl)3-(N- Phosphoglycerate 1: UGD1 isomerase: PMI1 9beta,19- Glyceraldehyde-3-phosphate oligosaccharide CO2 methanol mannosyl- acetylglucosaminyl) kinase, chloroplastic: PGK cyclo-5alpha- 4: PRS4 isomerase: isomerase: oxidation II 1,4-N-acetyl- IMP FCA1 xanthosine UDP-glucose 4- dehydrogenase: GPDA At2g01290 oxidation to [+ 3 isozymes] UDP-D- ergost-24(241) [+ 2 isozymes] Glyceraldehyde-3-phosphate XYLA fixation into beta-D- adenine 2-diphosphodolichol epimerase: galE D-mannose [+ 2 isozymes] D-xylulose- (glutathione- formaldehyde II Uridine CDP glucuronate -en-3beta-ol dehydrogenase 2: gpd3 oxaloacetate glucosaminyl-R Uracil [+ 6 isozymes] 6-phosphate 5-phospho- 5-phosphate dependent) kinase: udk Glycolipid 2-alpha- alpha-D- [+ 3 isozymes] D-xylulose (anapleurotic) phosphoribosyltransferase: upp Purine nucleoside fumarate Phosphoglycerate D-ribose-5- formaldehyde methanol Inosine-5’- mannosyltransferase: 1,3-bisphospho-D-glycerate ribose 1- val beta-D- Adenylosuccinate Uracil Nucleoside phosphorylase 1: punA Valine- 1,3-bisphospho-D-glycerate kinase, chloroplastic: PGK phosphate CO2 RNase II a [protein]-N4- monophosphate Adenine KRE2 UDP-D-glucose xylopyranose (S)-3- a reduced alpha-D- synthetase: phosphoribosyltransferase: diphosphate diphosphate -tRNA Rubisco shunt [+ 3 isozymes] L-threonine a protein- (2E,6E) degradation 15-cis- an UDP-D- (N-acetyl-D- dehydrogenase: phosphoribosyltransferase: apt uracil [+ 2 isozymes] Phosphomannomutase: Xylulose cellobiose lathosterol R’C(R)SH a ribonucleoside isopentenyl DNAn pyridoxal an aldehyde L-lactaldehyde hydroxybutanoyl- L-aspartyl- a polypeptide adenosine electron- glucose 6- a ferrocytochrome stearoyl- a deoxyribonucleoside an aldehyde PITG_16736 FUR1 kinase 4, ligase: valS L-valyl- Fumarate hydratase GDP-alpha- O-3- L-tyrosine -farnesal a phosphoprotein substrate a protein UQ a plastoquinone phytoene acetylated glucose glucosaminyl) DNAn 4-hydroxysphinganine phosphoribosyl- impdh Glyceraldehyde-3-phosphate PMM kinase: Xylb NAD-dependent monophosphate diphosphate CoA tRNAasn transfer phosphate b5 CoA GTP triphosphate ADP-ribose chloroplastic: xanthine cycloeucalenone tRNAval class II: fumC 3-phospho-D-glycerate Transketolase: Putative carbonic methanol D-mannose phosphate phosphate mRNA histone -L-asparagine ATP a (mannosyl)5-(N- dehydrogenase: GPDA D-fructose- D-xylulose flavoprotein UMP NDK4 Fumarate hydratase TKL1 anhydrase 3: cah-3 dehydrogenase: Lactase- acetylglucosaminyl) [+ 2 isozymes] tRNAval 6-phosphate kinase: xylB Delta(7)- Putative 3-oxoacyl- Aldehyde Probable aldehyde Aldehyde Probable 3- Tripeptidyl- Phytoene Alpha,alpha- Putative Ceramide [+ 2 isozymes] alpha-D-mannose class I, aerobic: fumA Transketolase: [+ 4 isozymes] mdh phlorizin Cytosolic 5’- Dual specificity 4-hydroxy- DNA Ribonuclease H2 Purine nucleoside Retrovirus- adenylo- AMP 2-diphosphodolichol 1-phosphate tkt-1 sterol-C5(6) FAD-linked Putative [acyl-carrier- dehydrogenase Dual specificity dehydrogenase: dehydrogenase hydroxyacyl-CoA Glutamyl-tRNA(Gln) peptidase Putative Electron transfer dehydrogenase: Histone trehalose- Stearoyl- uncharacterized synthase Xanthine 2,3-bisphosphoglycerate- [+ 5 isozymes] hydrolase: nucleotidase protein 3-methylbut- polymerase subunit A putative: phosphorylase related Pol succinate XMP S-hydroxymethylglutathione -desaturase sulfhydryl GDP- threonine- protein] family 3 member protein FIS1 family 3 member dehydrogenase amidotransferase 2: TPP2 serine flavoprotein- carB deacetylase phosphate CoA GTP protein: 4: CERS4 ATP phosphoribosyltransferase: CTP phosphoribosyltransferase: xpt dependent phosphoglycerate D-xylulose- Lct phosphatase: 2-enyl epsilon AlNc14C123G6738 1: punA polyprotein Transketolase: 1: STE1 oxidase mannose 3,5- 3: nt5c3 phosphate reductase H1: ALDH3H1 phosphatase: Aldehyde H1: ALDH3H1 B0272.3: subunit A: gatA Tripeptidyl- protease ubiquinone Phytoene 1: HDAC1 synthase desaturase cyclohydrolase SCAT_4833 Ceramide HIS1 D-glyceraldehyde-3-phosphate (S)-malate mutase: gpmA 5-phosphate D-mannose bicarbonate Cytosolic 5’- VH-PTP13 subunit Ribonuclease from dihydroxyacetone phosphate TKL1 D-glyceraldehyde- D-sedoheptulose- Lactase- epimerase: decarboxylase: diphosphate VH-PTP13 Probable aldehyde B0272.3 [+ 3 isozymes] HhoA: hhoA oxidoreductase, [+ 2 isozymes] [UDP-forming] 5: SCD5 1: SPAC17A5.13 synthase Lathosterol 347L: C: DPB3 FabG: fabG Probable aldehyde dehydrogenase Z: rnz peptidase dehydrogenase: [+ 3 isozymes] transposon Probable glutamine Transketolase: [+ 6 isozymes] 3-phosphate 7-phosphate degradation Alcohol formaldehyde phlorizin nucleotidase cobD [+ 14 isozymes] reductase: ispH [+ 11 isozymes] mitochondrial: oxidase: IIV6-347L At5g28840 [+ 5 isozymes] [+ 2 isozymes] dehydrogenase: family 3 member dehydrogenase: [+ 2 isozymes] 2: TPP2 [+ 2 isozymes] carB 5: TPS5 [+ 2 isozymes] 297: pol 6: CERS6 Adenylosuccinate amidotransferase XMP cycloeucalenol tkt-1 dehydrogenase hydrolase: III: NT5C3 ETFDH 5-phospho- a (mannosyl)6-(N- Alanine- Malate dehydrogenase, SC5DL [+ 2 isozymes] (R)-1- 1-hydroxy-2- FIS1 H1: ALDH3H1 FIS1 alpha-D- [+ 2 isozymes] 7,8- lyase: ADSL DUG3: DUG3 acetylglucosaminyl) Fructose-bisphosphate aldolase, -tRNA D-mannose class-3: ADHIII Phosphoenolpyruvate Lct L-asparaginyl- adenine ribose-1- 9,15,9’-tri- a deacetylated N6-acetyl- N-acetyl-beta- a [protein]- ATP alpha-D- ala mitochondrial: MDH2 amino-2- a [protein]- methyl-2-(E) acetoacetyl- a nucleoside formate dihydroneopterin ribose 1- 2-diphosphodolichol chloroplastic: Os11g0171300 ligase: 2-phospho-D-glycerate carboxylase: ppc tRNAasn monophosphate phosphate an oxidized cis-zeta- histone L-lysine a ferricytochrome glucosaminylamine L-aspartate D-erythrose- Transaldolase: tal 6-phosphate GDP-L- propanol L-tyrosine -butenyl 4- a nucleoside 4-pyridoxolactone (2-trans- a protein a polypeptide a tripeptide a peptide a peptide a plastoquinol trehalose 6- oleoyl-CoA triphosphate DNAn a phytoceramide Cycloeucalenol ALATS beta-D- 7-dehydro- R’C(R)S- a ribonucleoside monophosphate a carboxylate CoA electron- carotene UDP diphosphate [+ 3 isozymes] GDP-alpha- 4-phosphate Transaldolase: tal galactose O-2- diphosphate 6-trans)- (S)-lactate UQH2 b5 cycloisomerase: S-formylglutathione glucose cholesterol S(R)CR’ transfer phosphate D-mannose [+ 2 isozymes] L-alanyl- oxaloacetate phosphate farnesoate AMP GMP CPI1 Enolase: PGH1 Mannose-6- oxaloacetate flavoprotein tRNAala phosphate AMINES AND POLYAMINES BIOSYNTHESIS Transaldolase: tal Enolase: PGH1 D-erythrose- D-fructose- fructose-1,6-bisphosphate tRNAala 4-phosphate 6-phosphate isomerase: a (mannosyl)7-(N- Transaldolase: tal S-formylglutathione obtusifoliol Phosphoenolpyruvate PMI1 acetylglucosaminyl) GDP-mannose 4,6- hydrolase: ESD (6E,8Z,11Z,14Z) 1-(5-phosphoribosyl)-5- carboxykinase [ATP]: pckA a (R)-3- a damaged a [TusE sulfur 5-(methylthio) 2-diphosphodolichol dehydratase: gmd phosphoenolpyruvate 4alpha- all-trans- alpha- an (3R)-3- -(5s)-5- (S)-3- divinyl a tRNA [(5-phosphoribosylamino) Fructose-1,6-bisphosphatase, Phosphoenolpyruvate Transketolase: methyl- zeta- a stearoyl- dihydroxyacetone dimethylallyl L(or D)-O- a nucleoside octanal L-lactaldehyde hydroxyhexanoyl- hydroxy-cis- meso- a polypeptide guanine46 DNA a malonyl- a decanoyl- a reduced carrier protein]-S- -2,3- sn-glycerol- a palmitoyl- 1-palmitoylglycerol a deoxyribonucleoside chloroplastic: FBP GDP-mannose D-glyceraldehyde- D-sedoheptulose- D-fructose- tocopherol glt hydroxymyristoyl- hydroperoxycosa- in tRNA NADP+ protochlorophyllide a uridine34 ubiquinone-8 DNAn methylideneamino]imidazole- phosphoribosyl- UDP-N- choline putrescine Obtusifoliol carboxykinase [ATP]: pckA 3-phosphate 7-phosphate TKL1 6-phosphate formate zymosterol carotene ATP [acp] diphosphate phosphoserine triphosphate CoA vaccenoyl- diaminopimelate pyrimidine [acp] [acp] flavodoxin sulfanylcysteine dioxopentyl 3-phosphate [acp] 3-phosphate triphosphate Probable Dol-P- [+ 7 isozymes] 4,6 dehydratase [acp] 6,8,11,14- phosphate 4-carboxamide ATP acetyl-D- glycine betaine degradation I biosynthesis III Man:Man(7)GlcNAc(2) 2: gmd-2 14-alpha Pyruvate kinase: pyk Transketolase: tetraenoate [acp] glycine betaine demethylase: Asparagine- tkt-1 Zeta- Leukotriene- Aldehyde Aldehyde Probable 3- Tripeptidyl- tRNA (guanine-N(7) Formamidopyrimidine- Protochlorophyllide Mitochondrial 1-(5-phosphoribosyl)-5- glucosamine biosynthesis -PP-Dol alpha-1,6- [+ 3 isozymes] Putative 3,4- 4-hydroxy- Chaperone Probable bifunctional Glycerol-3- DNA biosynthesis CYP51 -tRNA phosphoenolpyruvate Transketolase: Emopamil- carotene B(4) omega- Arginine Acyl-[acyl- Phosphoserine dehydrogenase Rhamnolipids dehydrogenase hydroxyacyl-CoA (3R)- Diaminopimelate peptidase -)-methyltransferase DNA glycosylase: mutM 3-oxoacyl- Ferredoxin-- reductase, tRNA-specific 1-acyl-sn- [(5-phosphoribosylamino) mannosyltransferase: D-fructose-6-phosphate dihydroxy- 3-methylbut- protein Arachidonate 5- methylthioribulose- phosphate polymerase biosynthesis II II (Gram- asn ligase: asnS TKL1 glucose and glucose-1- binding desaturase: hydroxylase DNA biosynthesis carrier-protein] phosphatase: family 3 member biosynthesis 3- family 3 member dehydrogenase hydroxymyristoyl- decarboxylase: lysA 2: TPP2 B: mettl1-B Putative [acyl-carrier- NADP reductase, chloroplastic: PORA 2-thiouridylase glycerol-3- methylideneamino] ATP phosphoribosyltransferase: I (Gram- choline CG8412 GDP-4-dehydro- 4alpha- ALCOHOLS DEGRADATION 2-butanone 2-enyl ClpB1: lipoxygenase: 1-phosphate dehydrogenase, epsilon D-fructose- positive L-ornithine Asparagine- D-glyceraldehyde- protein- crtQ 1: CYP4F2 bifunctional desaturase 7, PSPH H1: ALDH3H1 oxoacyl-[acyl- H1: ALDH3H1 B0272.3: [acyl-carrier-protein] Diaminopimelate Tripeptidyl- tRNA (guanine-N(7) DNA protein] embryo isozyme, Protochlorophyllide 1: trmu phosphate imidazole-4- negative 6-deoxy- methyl- Transketolase: pyruvate phosphate degradation helicase kinase: diphosphate CLPB1 ALOX5 dehydratase/enolase- mitochondrial: subunit HIS1 6-phosphate -tRNA 3-phosphate like: Ebpl Zeta- Leukotriene- II: uvrD protein ArgJ, chloroplastic: Phosphoserine Probable aldehyde carrier-protein] Arachidonate 5- B0272.3 dehydratase: fabZ decarboxylase: lysA peptidase -)-methyltransferase: glycosylase synthase chloroplastic: reductase A, tRNA-specific acyltransferase carboxamide isomerase, bacteria) a (mannosyl)8-(N- Glucose-6-phosphate D-mannose 5alpha- tkt-1 a [pyruvate dehydrogenase DHBK reductase: ispH [+ 126 isozymes] Probable aldehyde phosphatase E1: GPD2 C: DPB3 bacteria) ligase: asnS L-asparaginyl- alpha-D- carotene B(4) omega- [+ 127 isozymes] mitochondrial: FAB2 phosphatase: dehydrogenase: reductase: rhlG lipoxygenase: dehydrogenase: [+ 2 isozymes] 2: TPP2 trmB Mb2491c: 2: fabF Os07g0147900 chloroplastic: PORA 2-thiouridylase 1, chloroplastic: chloroplastic: HIS6 choline Choline acetylglucosaminyl) isomerase, cytosolic 1: PGIC1 ergosta- E2 protein] N6-(lipoyl)lysine 4alpha- Os11g0484000 [+ 22 isozymes] 5-phospho- choline tRNAasn glucose 1- hydroxylase PITG_04698 PSPH FIS1 [+ 3 isozymes] Mb2491c [+ 2 isozymes] mnmA: mnmA LPAT1 dehydrogenase: Ornithine 2-diphosphodolichol Glucose-6-phosphate 8,14,24(28)- Glyceraldehyde- ethanol methyl- desaturase: 1-hydroxy-2- ALOX5 FIS1 a cis- alpha-D- Glucosamine- D-xylulose- D-ribose-5- Pyruvate dehydrogenase E1 phosphate 1: CYP4F2 dihydroxyacetone ATP betA decarboxylase: isomerase, cytosolic: PGIC GDP-L-fucose trien-3beta-ol tRNAasn 3-phosphate ethanol ethanol 5alpha- crtQ methyl-2-(E) a nucleoside 3-oxohexanoyl- vaccen-2- lys N7- a DNA dihydroxyacetone ribose 1- -fructose-6- spermidine phosphate degradation II an oleoyl- phosphate a polypeptide a tripeptide methylguanine46 an oxidized divinylchlorophyllide a a [TusE ubiquinol-8 phosphoribulosylformimino- Choline [+ 4 isozymes] ODC1 synthase: ger 5-phosphate component subunit beta: pdhB dehydrogenase: cholesta- N-acetyl-L- -butenyl 4- diphosphate a 3-oxo- enoyl-[acp] containing a a 3-oxo- NADPH 5-methylthioribulose- phosphate phosphate Choline Dihydrolipoyl dehydrogenase: lpdA degradation IV degradation I [acp] (L) or (D) octanoate leukotriene CoA flavodoxin a tRNA 2- sulfur carrier dipalmitoyl DNAn AICAR-P diphosphate dehydrogenase: biosynthesis I Probable Dihydrolipoyl dehydrogenase, [+ 2 isozymes] GPDA Probable 7,24-dien- 13’-hydroxy- ADP diphosphate (S)-lactate in tRNA apyrimidinic dodecanoyl- 1-phosphate a holo-[acp] aminotransferase dehydrogenase: all-trans glutamate -serine myristoyl- A4 a holo-[acp] thiouridine34 protein]- phosphatidate betA Ribulose- ribose-5- pseudouridine-5’- 3beta-ol alpha- site [acp] [isomerizing]: glmS betA betaine beta-D-glucose-6-phosphate mitochondrial: LPD [+ 2 isozymes] ethanol neurosporene [acp] L-cysteine putrescine a (mannosyl)9-(N- phosphate phosphate monophosphatase: ethanol tocopherol [+ 4 isozymes] aldehyde S-adenosyl- 4alpha- ethanol GDP-L-fucose 3-epimerase: isomerase: Dihydrolipoyllysine-residue Gs1l betaine L-methionine acetylglucosaminyl) methyl- 1,3- alpha-D- D-glucosamine- 2-diphosphodolichol GDP-L-fucose Aspartate-- rpe At2g01290 acetyltransferase acomponent [pyruvate dehydrogenase bisphospho- [+ 6 isozymes] aldehyde 5alpha- a [pyruvate dehydrogenase E2 glucose 6- Alcohol 6-phosphate betaine Betaine aldehyde tRNA ligase, Ribulose- Probable of pyruvate dehydrogenaseE2 protein] N6-(S- D-glycerate 3-(4- 2-[(2R,5Z)- biosynthesis ergosta- protein] N6-(dihydrolipoyl)lysine phosphate dehydrogenase: Alcohol a feruloyl- N-acetyl-D- aldehyde cytoplasmic: phosphate ribose-5- complex, mitochondrial:acetyldihydrolipoyl)lysine Dlat Catalase: CAT hydroxyphenyl) a (R)-3- an (R)-3- a (3R)-3- hydrogen O-acetyl- a [protein]- lotaustralin hydrogen UDP-D- (2-carboxy-4- dehydrogenase II (from 8,24-dien- adh dehydrogenase: adh an acyl-CoA histidinol a stearoyl- (R)-lactate kynurenine a ferricytochrome arachidonate L-lactaldehyde a monoacylglycerol dihydrolipoamide an RNA a malonyl- an octanoyl- polysaccharide 2-oxoglutarate L-aspartate- cob(I) a polycistronic 3-mercaptopyruvate galactosamine- Betaine aldehyde 2, mitochondrial: S-adenosylmethionine DARS 3-epimerase: phosphate [+ 2 isozymes] Phosphoglycerate D-glucose -3-hydroxy- hydroxystearoyl- hydroxyoctanoyl- hydroxyacyl- selenide L-serine GDP-L- L-aspartate pyruvate cyanide galactose 4-amino-2-methyl-5- methylthiazol- UDP-D- 3beta-ol Putative [+ 7 isozymes] [+ 7 isozymes] IMP dGDP dGDP [acp] b5 [acp] [acp] semialdehyde ATP yrinate a,c- tRNA precursor [glycoprotein] dehydrogenase ALDH10A9 decarboxylase L-fucose) Aspartate-- RPE isomerase: kinase, propionyl-CoA [acp] [acp] [acp] galactose diphosphomethylpyrimidine 5(2H)- Betaine aldehyde proenzyme: amd1 a glucosyl- galacturonate asp glucose-6- glycerol diamide 2, mitochondrial: Betaine aldehyde L-fucose Emopamil- tRNA ligase, At2g01290 chloroplastic: PGK acetaldehyde Feruloyl ylidene]ethyl dehydrogenase (mannosyl)9-(N- phosphate degradation I Peroxisomal Histidinol D-isomer specific Kynurenine-- Aldehyde Hormone- Dihydrolipoyl Exosome Cysteine Aspartyl/ Lactase- 3-mercaptopyruvate ALDH10A9 dehydrogenase biosynthesis I binding cytoplasmic: [+ 3 isozymes] Trifunctional Arachidonate 5- esterase phlorizin Glycoprotein-N- phosphate 2, mitochondrial: acetylglucosaminyl) acetyl-CoA 1-epimerase: acetaldehyde acetaldehyde acyl-coenzyme dehydrogenase: Acyl-[acyl- 2-hydroxyacid oxoglutarate NADH- Rhamnolipids Rhamnolipids dehydrogenase sensitive (3R)- dehydrogenase: complex synthase, 3-oxoacyl- asparaginyl Uncharacterized Ribonuclease H2 sulfurtransferase: acetylgalactosamine N-acetyl-D- Betaine aldehyde 2, mitochondrial: S-adenosyl-L- (from UDP-D- protein- DARS L-aspartyl- enzyme lipoxygenase: B: ESTA hydrolase: ALDH10A9 putrescine 2-diphosphodolichol UDP-D- yeaD GMP Nucleoside Ribonucleoside- A oxidase hisD carrier-protein] dehydrogenase subunit alpha, transaminase: cytochrome biosynthesis 3- biosynthesis 3- family 3 member lipase: LIPE hydroxymyristoyl- lpdA component chloroplastic/ GDP-L-galactose [acyl-carrier- beta- DAPA-like lyase Cob(I)yrinic subunit A putative: sseA 3-beta- Thiamine- glucosamine- dehydrogenase ALDH10A9 methioninamine like: Ebpl tRNAasp Aldehyde glycerol ALOX5 Probable Lct 6-phosphate Betaine aldehyde glucuronate) oxaloacetate 3-phospho- Glucose-6- reductase diphosphate diphosphate 1: Acox1 Histidine desaturase 7, NAD-binding mitochondrial: ccbl b5 reductase oxoacyl-[acyl- oxoacyl-[acyl- H1: ALDH3H1 Hormone- [acyl-carrier-protein] Dihydrolipoyl RRP43: chromoplastic: phosphorylase protein] hydroxylase: Caur_1967: acid a,c-diamide AlNc14C123G6738 Putative 3- galactosyltransferase phosphate 2, mitochondrial: L-fucose glucuronate beta-D- Arachidonate 5- feruloyl Lactase- dehydrogenase D-glycerate phosphate Aldehyde dehydrogenase Probable aldehyde 2: Gmpr2 kinase: swoH reductase large Putative biosynthesis chloroplastic: protein: Kynurenine-- 2: CYB5R2 carrier-protein] carrier-protein] Probable aldehyde sensitive dehydratase: fabZ dehydrogenase, EXOSC8 CYSK 1: VTC2 synthase ASPH Caur_1967 adenosyltransferase, mercaptopyruvate 1: C38H2.2 synthase: ALDH10A9 kinase: FUK tRNAasp HADHA lipoxygenase: esterase phlorizin Ribonuclease 2, mitochondrial: glycine Citrate synthase, mitochondrial: cs glucose 1-epimerase: dehydrogenase family 3 member dehydrogenase: FIS1 [+ 2 isozymes] subunit: RNR1 peroxisomal trifunctional FAB2 Snas_3082 [+ 2 isozymes] oxoglutarate [+ 3 isozymes] reductase: rhlG reductase: rhlG dehydrogenase: lipase: LIPE mitochondrial: LPD [+ 6 isozymes] 2: fabF [+ 2 isozymes] Dihydrodipicolinate mitochondrial: Mmab sulfurtransferase: thiE Spermidine synthase UDP- 24-methylenelophenol ALOX5 C: faeC Z: rnz Phosphoacetylglucosamine ALDH10A9 betaine YMR099C family 3 member H1: ALDH3H1 Glycerol [+ 3 isozymes] acyl-coenzyme protein: HIS4 transaminase: [+ 3 isozymes] [+ 3 isozymes] FIS1 a trans- [+ 2 isozymes] hydrolase: synthase: dapA SPCC4B3.01 1: SPDSYN1 a (glucosyl) glucuronate Lct beta-D- mutase: PGM3 glycine beta-L- 2,3-bisphosphoglycerate- H1: ALDH3H1 Probable aldehyde kinase: glpK A oxidase 3-(4- ccbl (6E,8Z,11Z,14Z) delta2- alpha-L- a tRNA 2(mannosyl)9-(N- 4-epimerase Glucokinase: hydroxyphenyl) a peptide adenosyl- galactosyl-1,3- betaine fucose 1- dependent beta-D- Probable aldehyde dehydrogenase: Glycerol acetyl-CoA GMP 1.2: ACX1.2 an oleoyl- pyruvate a ferrocytochrome -(5s)-5- glycerol a carboxylate enoyl- lipoamide a nucleoside selenocysteine acetate GDP galactose-1- succinate 3-hydroxy- cobyrinate PPPi precursor N-acetyl-D- UDP thiamin N-acetyl-alpha- glycine acetylglucosaminyl) 4: GAE4 phosphoglycerate glcK -3-oxo- a 3-oxo- a 3-oxo- an RNA a 3-oxo- a polysaccharide (S)-2,3- phosphate S-methyl-5’- phosphate glucose-6- dehydrogenase: FIS1 kinase: glpK dGTP histidinal [acp] 4-(2- b5 hydroperoxycosa- (S)-lactate acyl-[acp] diphosphate phosphate ferulate L-aspartate a,c-diamide with a 5’ a polycistronic pyruvate thiocyanate galactosaminyl- D-glucosamine betaine spermidine 2-diphosphodolichol UDP- mutase: gpmA Glucokinase: glk propionyl-CoA stearoyl- octanoyl- decanoyl- a holo-[acp] (2R)-2-hydroxy-2- beta-D- dihydrodipicolinate Tyrosine- phosphate FIS1 GDP aminophenyl)-2,4- 6,8,11,14- extension tRNA precursor 1-phosphate thioadenosine glucuronate a trans-2- [acp] [acp] [acp] methylbutanenitrile glucose [glycoprotein] Dol-P-Glc:Glc(2) -tRNA Malate dehydrogenase, [+ 6 isozymes] dioxobutanoate tetraenoate and a short 4-epimerase 4alpha- tyr D-ribulose- (S)-malatemitochondrial: MDH2 citrate beta-D- D-glucono- sn-glycerol- enoyl-CoA Man(9)GlcNAc(2)- ligase: acetate 3’ extension 4: GAE4 hydroxymethyl- 5-phosphate glucose-6- 1,5-lactone 3-phosphate Probable UDP-N- PP-Dol alpha-1,2- YARS acetate 24-ethylidenelophenol 2-phospho- phosphate acetylglucosamine glucosyltransferase: UDP-D- ergosta- [+ 2 isozymes] 7,24(241)- L-tyrosyl- D-glycerate pyrophosphorylase: ALG10 galacturonate Phosphoribulokinase, Gluconolactonase: gnl Acetate--CoA 1-(o- tRNAtyr Glycerol-3- a protein DNA combined 4,4- At2g35020 dien-3beta-ol chloroplastic: PRKA Probable aconitate hydratase, Fibronectin type Acetate--CoA ligase ACS, naringenin dTDP-alpha- an (R)-3- an alpha-D- 1-(5- a ubiquitin a 2,3,4- a 2,3,4- GDP-L- phosphate a [protein]- with with exogenous dimethyl- carboxyphenylamino) a (R)-3- O-acetyl- guanine527 a 1-acyl-sn- (S)-2,3,4,5- an organic shikimate-3- a polycistronic fructose-1- tRNAtyr mitochondrial: aco2 Enolase: III domain protein: ligase ACS, chloroplastic/ D-glucose OPC8-CoA acetyl-CoA -1’-deoxyribulose- mannoside thiosulfate a malonyl- saturated a reduced 2-oxoglutarate isochorismate saturated a 2,3,4-saturated 2- UDP-alpha- an oligosaccharide- fucose Fumarate hydratase class II: fumC dehydrogenase, chalcone a phosphorylase b L-histidine reduced DNA to form a a protein 5alpha- hydroxypalmitoyl- hydroxydodecanoyl- phospho- L-serine in 16S rRNA C-terminal an ADP- an acyl-[acp] glycerol-3- tetrahydrodipicolinate phosphate phosphate PGH1 VDG1235_3084 chloroplastic/ glyoxysomal: ACS IMP [acp] fatty flavoprotein molecule tRNA precursor fatty lysophosphatidate IMP N-acetyl-D- D-ribulose-1,5- Fumarate hydratase sulfide recombinational cholest-7- [acp] 5’-phosphate [acp] D-ribosyl) thioester sugar phosphate diphosphodolichol 4alpha- Enolase: glyoxysomal: ACS [+ 2 isozymes] mitochondrial: acyl-[acp] acyl-[acp] glucosamine class I, aerobic: fumA groups junction en-3beta-ol Predicted -AMP hydroxymethyl- 4alpha- bisphosphate PGH1 GPD2 Similar to Peroxisomal [Pyruvate Propionyl-CoA Ribosomal RNA Dihydrodipicolinate fumarate cis-aconitate [+ 2 isozymes] Probable Indole-3- protein: Cysteine 3-phosphoshikimate 1- 2-succinyl-5- Fructose- stigmasta- acyl-coenzyme Calcium/ dehydrogenase carboxylase Protein Extracellular Rhamnolipids Rhamnolipids small subunit Ubiquitin 3-oxoacyl- 1-acyl-sn- Cytochrome Probable 1- formyl- Probable aconitate hydratase, D-gluconate Chalcone rhamnose Putative Methylsterol glycerol v1g244860 synthase, reductase 1, carboxyvinyltransferase, enolpyruvyl- Ribonuclease H2 bisphosphate 7,24(241)- ergosta- acetyl-CoA Isomerase: A oxidase calmodulin- [lipoamide]] beta chain, disulfide- signal- monooxygenase biosynthesis 3- biosynthesis 3- Histidine chloroplastic/ methyltransferase carboxyl- [acyl-carrier- glycerol-3- P450: acyl-sn-glycerol- aldolase, Ribulose mitochondrial: aco2 dihydroxyacetone Cytosolic 5’- biosynthetic Holliday phosphate Lysosomal ADP-sugar chloroplastic: DAPB1 chloroplastic: At2g45300 6-hydroxy-3- subunit A putative: Xanthine dien-3beta-ol 7,24(241) Tryptophan- phosphoenolpyruvate CHI 1: Acox1 dependent kinase, mitochondrial: isomerase regulated 1: Msmo1 oxoacyl-[acyl- oxoacyl-[acyl- biosynthesis chromoplastic: G: rsmG terminal pyrophosphatase: protein] phosphate Dihydrodipicolinate CYP97E3 3-phosphate chloroplastic: bisphosphate acetyl-CoA phosphate nucleotidase enzyme junction synthase: alpha- cyclohexene- AlNc14C123G6738 phosphoribosyltransferase: xpt -tRNA Chalcone Putative protein mitochondrial: PCCB TMX3: tmx3 kinase 1: erkA carrier-protein] carrier-protein] trifunctional Ribosomal RNA hydrolase synthase acyltransferase reductase 1, Flavoprotein 3-phosphoshikimate 1- acyltransferase: COFACTORS, PROSTHETIC GROUPS, ELECTRON CARRIERS BIOSYNTHESIS -dien- carboxylase melibiose III: NT5C3 1: RHM1 resolvase: Methylsterol trpC mannosidase: CYSK NUDT5 carboxyvinyltransferase, 1-carboxylate Ribonuclease Os11g0171300 [+ 2 isozymes] 3beta-ol ligase: trpS Isomerase: Cytosolic 5’- peroxisomal kinase type SPAC644.11c [+ 2 isozymes] [+ 25 isozymes] [+ 4 isozymes] monooxygenase reductase: rhlG reductase: rhlG protein: HIS4 small subunit 15: Usp15 2: fabF 1, chloroplastic: chloroplastic: DAPB1 Monooxygenase: SLC1 [+ 3 isozymes] large chain: rbcL Probable CAB571 [+ 3 isozymes] manA chloroplastic: At2g45300 synthase: menD Z: rnz Tryptophan-- Pyruvate degradation CHI nucleotidase acyl-coenzyme II: unc-43 [+ 4 isozymes] 1: Msmo1 [+ 3 isozymes] [+ 3 isozymes] methyltransferase [+ 17 isozymes] [+ 2 isozymes] LPAT1 Esi_0008_0229 [+ 4 isozymes] tRNAtrp rhamnose a protein [+ 2 isozymes] 1-(5-phosphoribosyl)-5- 5-phospho- tRNA ligase, A oxidase (1S,2R) G: rsmG an alpha-D- 2-succinyl-5- a tRNA 4alpha- kinase: pyk 3: nt5c3 biosynthetic with resolution of 4beta- [(5-phosphoribosylamino) S-sulfo- (S)-2,3- alpha-D- cytoplasmic: 3-phospho- [+ 3 isozymes] 1.2: ACX1.2 a protein N- malonyl-CoA -1-C- alpha-D- an organic acetate AMP aldose-1- a 1,2- 5-enolpyruvyl- enolpyruvyl- precursor dihydroxyacetone hypoxanthine molybdenum cofactor biosynthesis formyl- succinate D-threo-isocitrate melibiose (2S)- enzyme oxidized recombinational a phosphoprotein hydroxymethyl- a 3-oxo- a 3-oxo- methylideneamino]imidazole- L-cysteine dihydrodipicolinate a 2,3,4- D-glyceraldehyde Wars L-tryptophanyl- D-glycerate phospho- (indol-3-yl) mannose molecule phosphate a 3-oxoacyl- diacyl-sn- an oxidized shikimate-3- 6-hydroxy-3- with a 5’ a polycistronic phosphate ribose 1- stigmasta- 4alpha- naringenin 2: RHM2 a phosphorylase a disulfide palmitoyl- dodecanoyl- 4-carboxamide N7-methylguanine527 a ubiquitin a thiol a holo-[acp] a holo-[acp] an alcohol saturated L- a holo-[acp] diphosphate NAD phosphopantothenate thiamin diphosphate biotin biosynthesis tRNAtrp PROTEIN DEGRADATION OPC8- L-histidine junction 4alpha-methyl- glycerol 3- [acp] glycerol-3- flavoprotein phosphate cyclohexene- extension tRNA precursor heme 7,24(241) carboxy- NUCLEOSIDES inosine bonds formation of two 5alpha-cholest- [acp] [acp] in 16S rRNA phosphatidate biosynthesis biosynthesis I biosynthesis III from 7-keto-8- Succinyl-CoA ligase [ADP- dTDP-4- trans-2- phosphate phosphate 1-carboxylate and a long biosynthesis from -dien- ergosta- 2,3-bisphosphoglycerate- pyruvate Alpha- AND NUCLEOTIDES dehydro- intact strands 7-en-3beta-ol 7,24(241) trp forming] subunit alpha- enoyl-CoA 3’ trailer cys I (from (Staphylococcus) aminopelargonate 3beta-ol dependent galactosidase: 6-deoxy- uroporphyrinogen-III I -dien- phosphoglycerate 1, mitochondrial: SCOA DEGRADATION aspartate) 2-(2-carboxy-4- rafA alpha-D- 2-oxoisovalerate 4-amino-2-methyl-5- 7-keto-8- 3beta-ol mutase: gpmA ATP-citrate synthase: ACLY Alpha- methylthiazol-5- D-lactate seed glucose uroporphyrinogen-III diphosphomethylpyrimidine aminopelargonate [+ 6 isozymes] galactosidase: wound- Probable asp yl)ethyl phosphate dehydrogenase: germination Os10g0493600 adenosine cysteine 3-methyl-2-oxobutanoate 4alpha- succinyl-CoA 2-oxoglutarate ldhA induced a small subunit of carboxy- protein 24-hydroxy- an all-trans cis- a tRNA guanine at desulfurase, hydroxymethyltransferase: Thiamine-phosphate Adenosylmethionine-8- 2-phospho- proteolysis I nucleotides a protein molybdopterin Uroporphyrinogen stigmasta- alpha-D- beta-D- turnover a (3R)-3- 3-oxocholest- retinol- imidazole an (R)-3- coumarinic [protein] N6- a cis-delta3- a glutaryl- a protein- precursor (2E,6E)- position mitochondrial: gamma-glutamyl cycle panB synthase: thiE amino-7-oxononanoate thr Threonine- D-glycerate degradation II [tRNAArg2]- OPC6-CoA D-glucosamine- succinate linamarin a deoxyribonucleoside S-farnesyl- nicotinamide a malonyl- a myristoyl- a nucleoside a malonyl- a malonyl- L-ascorbate antheraxanthin a [protein]- a glycerophosphodiester S-adenosyl- synthase L-aspartate decarboxylase: hemE (S)-lactate hydroxyacyl- [cellular- acetol- hydroxydecanoyl- acid-beta- (dihydrolipoyl) an RNA decenoyl- [acp] proline with a 5’ farnesyl preQ1 34 of a a tRNA CG12264 coenzyme A aminotransferase: bioA 7,24(241) -tRNA (R)-lactate galactose glucose AMP GMP adenosine34 6-phosphate 4-en-26- 8-oxo-dGTP diphosphate L-cysteine [acp] [acp] triphosphate [acp] [acp] L-cysteine L-methionine ATP CTP oxidase: Uroporphyrinogen -dien- episterone a peptide a peptide [acp] oyl-CoA retinol- phosphate [acp] D-glucoside lysine [acp] methyl ester extension diphosphate bacterial precursor Probable biosynthesis ligase: thrS nadB decarboxylase: hemE thiamin diphosphate 3beta-ol [+ 2 isozymes] Enolase: binding- and a short tRNA Adenylyltransferase cysteine 2-dehydropantoate L-threonyl- Peroxisomal Trifunctional Succinate Lactase- Lactase- Putative Probable Xaa-Pro Violaxanthin glutathione thiamin phosphate biosynthesis 7,8- PGH1 AMP Putative protein] Histidinol- Ribonucleoside- CAAX DNA- 3’ extension Protein Glycerophosphoryl and sulfurtransferase desulfurase: trans, trans- diaminopelargonate tRNAthr tRNA- acyl-coenzyme 3-oxoacyl- enzyme dehydrogenase Rhamnolipids phlorizin phlorizin Dihydrolipoyl prenyl nicotinamide N- 3-oxoacyl- 3-oxoacyl- 3-oxoacyl- aminopeptidase de-epoxidase, diester Alanine alpha- D-4’-phosphopantothenate Enolase: glucosamine- phosphate diphosphate directed farnesyltransferase Queuine tRNA- MOCS3 1: GA24966 csd farnesyl IV (eukaryotes) tRNAthr Probable Cytosolic 5’- specific A oxidase [acyl-carrier- subunit alpha, 7,8-dihydro- cytochrome Epidermal retinol biosynthesis 3- hydrolase: hydrolase: dehydrogenase: protease 1 methyltransferase: [acyl-carrier- [acyl-carrier- [acyl-carrier- P: AMPP chloroplastic: Ribonuclease H2 phosphodiesterase: aminotransferase CCA tRNA iminosuccinate coproporphyrinogen III PGH1 6-phosphate aminotransferase: reductase small RNA subunit beta: FTB ribosyltransferase: ORF: 4-methyl-5-(2- Probable cytosol Probable cytosol AMP adenosine 1: Acox1 protein] mitochondrial: 8-oxoguanine b560 subunit, dehydrogenase oxoacyl-[acyl- Lct Lct lpdA NNT1 protein] protein] protein] Xaa-Pro VDE1 subunit A putative: 2, mitochondrial: nucleotidyltransferase, a carboxy- diphosphate Putative gamma- 4-amino-2-methyl-5- nucleotidase deaminase- hisC chain: rnr-2 homolog: polymerase Protein qtrt1 glpQ GTP an [L-cysteine evm.model.contig01328.2 Purple acid phosphonooxyethyl) Adenosylmethionine-8- deaminase: III: NT5C3 deaminase: Putative reductase HADHA triphosphatase: mitochondrial: 2: SDR16C5 carrier-protein] Lactase- Lactase- Dihydrolipoyl FACE1 Putative synthase synthase synthase Violaxanthin AlNc14C123G6738 Glycerophosphodiester ALAAT2 mitochondrial: CCA1 adenylated glutamyltransferase phosphatase 21: PAP21 aminopeptidase: aminopeptidase: Cytosolic 5’- like protein Histidinol- [+ 3 isozymes] II subunit aminopeptidase farnesyltransferase Queuine tRNA- desulfurase]- biosynthesis [+ 2 isozymes] Phosphopantothenate- diphosphomethylpyrimidine amino-7-oxononanoate AMPD tadA peroxisomal FabG: fabG Nudt1 sdhC reductase: rhlG phlorizin dehydrogenase, nicotinamide N- 2: fabF 2: fabF 2: fabF de-epoxidase, [+ 2 isozymes] phosphodiesterase [+ 4 isozymes] CCA tRNA small subunit of Coproporphyrinogen- ywrD: ywrD thiazole avenastenone episterol phosphoenolpyruvate pepA pepA nucleotidase Cytosolic 5’- BT_0258: [+ 2 isozymes] an all-trans phosphate phlorizin rpb3: polr2c 1: xpnpep1 subunit beta: FTB ribosyltransferase: tgt S-sulfanyl- -cysteine ligase: PPCS [+ 9 isozymes] aminotransferase: bioA pseudouridine tRNA- acyl-coenzyme [+ 3 isozymes] Putative fumarate [+ 3 isozymes] hydrolase: mitochondrial: LPD methyltransferase: [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] chloroplastic: molybdopterin III oxidase, isopentenyl Probable cytosol Probable cytosol III: NT5C3 nucleotidase BT_0258 retinal- aminotransferase: hydrolase: a protein [+ 27 isozymes] a tRNA domain-containing nucleotidyltransferase, L-cysteine diphosphate Thiamine-phosphate degradation 3: nt5c3 specific A oxidase 3,24- reductase: Lct Lct NNT1 VDE1 7-aminomethyl- protein 1: GDPD1 mitochondrial: CCA1 synthase chloroplastic: CPX beta-alanine aminopeptidase: aminopeptidase: Cytosolic 5’- [cellular- HIS5 a ribonucleoside c-terminal precursor a single- Molybdenum (R)-pantoate synthase: thiE Serine-- adenosine 1.2: ACX1.2 dioxocholest-4- SPAC17A2.05 a peptide a 3-oxo- a protein- 7-deazaguanine S-methyl-5’- 1-aminocyclopropane- Coproporphyrinogen- R-4’-phosphopantothenoyl- dethiobiotin Pyruvate pepA pepA nucleotidase 8-oxo- retinol- a 3-oxo- a lipoyl- diphosphate S-farnesyl- a 3-oxo- a 3-oxo- with a stranded a farnesylated thiamin tRNA ligase, IMP deaminase a 3-oxoacyl- D-fructose- en-26-oyl-CoA cis-delta5- N-terminal- a peptide at position thioadenosine 1-carboxylate cofactor Adenylyltransferase III oxidase: Coprox L-cysteine kinase: pyk 3: nt5c3 dGMP binding- decanoyl- beta-D- acetone beta-D- carrier L-cysteine palmitoyl- a holo-[acp] a holo-[acp] pimelyl-[acp] a holo-[acp] L-dehydro- short 3’ RNA guanine a tRNA quinolinate Squalene Glutathione cytoplasmic: pseudouridine guanosine 2: adat2 OPC6- [acp] 6-phosphate coumarinate 1-methylnicotinamide an RNA dodecenoyl- Proline zeaxanthin protein 34 of a tRNA sn-glycerol- biosynthesis and sulfurtransferase [+ 3 isozymes] a peptide a peptide protein] L-histidinol- [acp] cyanohydrin glucose protein [acp] methyl ester ascorbate extension synthase: synthetase: gshB trans-2- glucose [acp] an alcohol 3-phosphate containing a protein MOCS3 1: GA24966 Pantothenate ser serS fumarate phosphate containing fdfT Glutathione synthetase, Phosphopantothenoylcysteine thiamin phosphate Biotin 5-dehydro enoyl-CoA 3’ CCA end 1: mocs1 protoporphyrinogen IX synthetase: panC Thiamin avenasterol Serine- adenosine GUN anticodon Isopentenyl- chloroplastic: GSH2 cysteinylglycine decarboxylase: Ppcdc pyrophosphokinase synthase: bioB episterol [tRNAArg2]- Nicotinate-nucleotide L-gamma- a 5-L-glutamyl- -tRNA pyruvate a thiocarboxylated diphosphate 1: TPK1 [+ 2 isozymes] inosine34 pyrophosphorylase glutamylcysteine L-amino acid ligase: serS L-seryl- cyclic pyranopterin small subunit of Delta- Purple acid [carboxylating] Protoporphyrinogen tRNAser monophosphate molybdopterin (R)-pantothenate (Fragment): qprt oxidase: hemY isomerase: idi1 4’-phosphopantetheine phosphatase 21: PAP21 Adenosine synthase [+ 9 isozymes] biotin tRNAser pseudouridine Nicotinate thiamin diphosphate FATTY ACID AND LIPIDS DEGRADATION deaminase: add Protoporphyrinogen 5’-phosphate 4beta- a [biotin- an electron- guanine at a tRNA beta-D- alpha-D- a 3’- a (R)-3- trans-1,2- 2-C- 9,9’-di- 1-deoxy- phosphoribosyltransferase: oxidase, dimethylallyl a cis-5- hydroxymethyl- an (R)-3- a tRNA carboxyl- transfer- 5-amino-6-(D- a cis-delta7- [lipoamide acyltransferase] N6-(S- position precursor galactosyl-1,4- a [protein]- an oligosaccharide- Molybdopterin naprt chloroplastic: PPOX1 Pantothenate Phosphopantetheine 5-dehydroavenasterol 24-methylenecholesterol oleamide glucose 6- phosphate- OPC4-CoA hydroxy-cis- histidinol a biotinylated dihydrobenzene- methyl-D- a malonyl- a hexanoyl- a malonyl- an acetyl- cis-zeta- a malonyl- a malonyl- a dodecanoyl- L-glycero- a malonyl- UDP-D- synthase catalytic diphosphate kinase 2: At4g32180 adenylyltransferase: COAD thiamin enoyl-CoA met 4alpha-methyl- hydroxyhexanoyl- a protein uridine54 biotin carrier related an acyl-[acp] ribitylamino) tetradecenoyl- [2-methylbutanoyl]dihydrolipoyl) queuine 34 of a with a 5’ N-acetyl-beta- L-asparagine diphosphodolichol ORF: inosine phosphate terminated vaccenoyl- an mRNA ATP [BCCP dimer] 1,2-diol erythritol-4- GTP [acp] [acp] [acp] [acp] carotene [acp] [acp] [acp] tetrulose 4- [acp] galactose Pseudouridine- 5alpha-cholest- [acp] protein quinone uracil [acp] lysine bacterial extension D-glucosaminyl- subunit: MOCS2 evm.model.contig03405.1 cys gly phospholipases RNA [acp] phosphate phosphate nicotinate D- 5’-phosphate 7-en-3beta-ol monomer] tRNA and a long [glycoprotein] protoporphyrin IX Farnesyl [+ 2 isozymes] D-4’- triacylglycerol 3-phosphoinositide Fatty-acid Glucose-6- Peroxisomal Peroxisomal Trans-1,2- tRNA (uracil(54) Zeta- ribonucleotide dephospho-CoA Proline- glycosidase: psuG RNA 3’- Histidinol 1-deoxy-D-xylulose 6,7-dimethyl-8- 3’ trailer diphosphate phosphopantothenate Thiamin -tRNA degradation amide phosphate acyl-coenzyme acyl-coenzyme Peptide Rhamnolipids Propionyl-CoA Rhamnolipids dihydrobenzene- Probable -C(5))- Biotin-- 3-oxoacyl- 3-oxoacyl- carotene 3-oxoacyl- 3-oxoacyl- 3-oxoacyl- Lipoamide Dolichyl- a 1-phosphatidyl- degradation terminal dehydrogenase: Methylsterol 5-phosphate ribityllumazine Queuine tRNA- Probable beta-1,3- molybdopterin synthase: fps pyrophosphokinase ligase: Purine nucleoside hydrolase isomerase, A oxidase A oxidase methionine biosynthesis 3- Poly(A) carboxylase biosynthesis 3- 1,2-diol serine/ methyltransferase: [acetyl-CoA- Probable GTP [acyl-carrier- [acyl-carrier- desaturase: [acyl-carrier- [acyl-carrier- [acyl-carrier- acyltransferase Ribonuclease H2 diphosphooligosaccharide- phycoerythrobilin 1D-myo-inositol a 1,2-diacylglycerol uracil hisD monooxygenase reductoisomerase: dxr synthase: ribosyltransferase: galactosyltransferase Ferrochelatase: [+ 6 isozymes] 1: TPK1 1-phosphatidyl- phosphorylase 1: FAAH cytosolic phosphate 1: Acox1 1: Acox1 sulfoxide oxoacyl-[acyl- polymerase: alpha chain, oxoacyl-[acyl- dehydrogenase: threonine- SPAC4G8.07c carboxylase] protein] protein] crtQ protein] protein] protein] component of subunit A putative: -protein glycosyltransferase Nicotinate-nucleotide biosynthesis pro proRS 4,5-bisphosphate cyclase: Histidine 1: Msmo1 1-deoxy-D-xylulose pyrophosphokinase: relA MGG_04626 qtrt1 16: B3GALT16 hemH Dephospho-CoA kinase: coaE Proline- a triacylglycerol 1D-myo- 1: punA Fatty-acid 1: PGIC1 Putative Putative reductase carrier-protein] papA mitochondrial: carrier-protein] Dhdh protein tRNA (uracil(54) synthetase: GTP synthase synthase Zeta- synthase synthase synthase branched-chain AlNc14C123G6738 subunit 2: ost2 adenylyltransferase: isofucosterol 24-methyldesmosterol biosynthesis Methylsterol 5-phosphate 6,7-dimethyl-8- Queuine tRNA- [+ 2 isozymes] inositol 3,4,5- Glucose-6- RTCD1 peroxisomal peroxisomal A3: MSRA3 reductase: rhlG PCCA reductase: rhlG Trans-1,2- kinase -C(5))- pyrophosphokinase: relA 2: fabF 2: fabF 2: fabF 2: fabF 2: fabF alpha-keto acid Ribonuclease [+ 4 isozymes] nadD glt 5-oxoproline folate polyglutamylation -tRNA amide trifunctional Poly(A) birA carotene lipoate geranyl hydrolase phosphate Probable acyl-coenzyme acyl-coenzyme [+ 2 isozymes] monooxygenase dihydrobenzene- pkwA: pkwA methyltransferase: reductoisomerase: dxr [+ 2 isozymes] [+ 2 isozymes] desaturase: [+ 2 isozymes] [+ 2 isozymes] ribityllumazine [+ 2 isozymes] dehydrogenase ribosyltransferase: tgt Z: rnz alpha-D- thiamin diphosphate protoheme IX ligase: proS L-prolyl- trisphosphate [+ 6 isozymes] [+ 3 isozymes] protein: HIS4 polymerase [+ 3 isozymes] diphosphate Triacylglycerol isomerase, RNA 3’- A oxidase A oxidase 1: Msmo1 [+ 160 isozymes] synthase complex, galactosyl- biosynthesis nicotinate protoheme IX tRNApro 1: FAAH gamma: 1,2-diol trmA a biotinylated crtQ a glycoprotein coenzyme A cytosolic: terminal 1-deoxy-D- (Precursor): ribH mitochondrial: Dbt a tRNA a tRNA (1,3)-beta-D- lipase: Phosphatidylinositol- hypoxanthine 1.2: ACX1.2 1.2: ACX1.2 Papolg 3beta-hydroxy- a 3-oxo- dehydrogenase: [BCCP a 3-oxo- a 3-oxo- a 3-oxo- with the adenylyl- and adenine tetrahydrofolate tRNApro phosphate a 3-oxo-cis- a carboxylated- xylulose 5- an an electron- containing precursor galactosyl-(1,4) UDP p-aminobenzoate Phospholipase At4g13550 3,4,5-trisphosphate 5- PGIC L-methionine- 4beta-methyl- dhdh a tRNA pppGpp a 3-oxoacyl- 6,7- cis-delta9- an [apo BCAA molybdopterin dinucleotide Farnesyl Heme oxygenase cyclase-like vaccenoyl- biotinylated hexanoyl- monomer] phosphate octanoyl- a holo-[acp] a holo-[acp] acetoacetyl- 7,9,9’-cis- transfer- a holo-[acp] myristoyl- a holo-[acp] a holo-[acp] GUN with a 5’ a nucleoside -N-acetyl-D- oligosaccharide dolichyl incorporation I D p2: PLDP2 a 1,2-diacyl- [+ 25 isozymes] phosphatase 2: Inppl1 oleate OPC4- a trans2,cis- (S)-S-oxide his 5alpha- containing 5- [acp] dimethyl-8- hexadecenoyl- chain attached Glutamine- biosynthesis 1: HMOX1 protein: rcl1 [acp] [BCCP dimer] [acp] a phosphoprotein [acp] [acp] neurosporene related [acp] dehydrogenase anticodon guanine extension monophosphate glucosaminyl- diphosphate delta24-25- a phosphatidylcholine sn-glycerol- a 1- trans-2- 5-dienoyl- cholest-7- methyluridine54 (1-D-ribityl) [acp] diphosphate dependent 24-epi- [+ 2 isozymes] D-fructose- an mRNA E2 protein] N6- with and a short by N-glycosyl an octanoyl-[acp] synthase: fps Serine sitosterol campesterol 3-phosphate phosphatidyl- enoyl-CoA CoA ene-4alpha- catechol quinol lumazine [glycoprotein] NAD(+) Formate-- campesterol 6-phosphate a 2’,3’-cyclic- (dihydrolipoyl) quenosine at 3’ extension linkage to protein 5-oxoprolinase: OXP1 a diacylglycerol a 1- 1D-myo- carbaldehyde synthetase: chorismate tetrahydrofolate hydroxymethyltransferase biliverdin-IX-alpha phosphate- lysine position 34 L-asparagine Nadsyn1 (2E,6E)- ligase: THFS 2: shmt2 phosphatidyl- inositol 4,5- terminated Octanoyltransferase: lipB farnesyl [+ 3 isozymes] Phenylalanine- 1D-myo- bisphosphate RNA molybdenum diphosphate -tRNA ligase inositol 3,4- Octanoyltransferase: lipB NAD+ Probable glutamine a tetrahydrofolate- 15,16- phe xanthine cofactor glutamate 10-formyl- alpha subunit: bisphosphate amidotransferase dihydrobiliverdin:ferredoxin DUG3: DUG3 tetrahydrofolate 5,10- sitosterol FARSA Group XIIA an electron- an electron- RNase II oxidoreductase: pebA a 2-lysophosphatidylcholine a non- 9,9’-di- a [ThiI sulfur- a peptide an octanoylated [+ 2 isozymes] methylenetetrahydrofolate crinosterol brassicasterol [+ 3 isozymes] L-phenylalanyl- secretory a 1- a 2,3,4- octanoyl- 4alpha-hydroxy- guanine37 transfer- transfer- 7,9,9’-cis- poly-A methylmalonate protein thioredoxin Folylpolyglutamate phospholipase a 2- saturated nitrite histidinal pyridoxamine methylated a ADP- Fe3+ sulfite cis-zeta- a malonyl- a butyryl- detyrosinated a malonyl- a palmitoleoyl- a [tRNAIle2]- protoporphyrin IX carrier a deoxyribonucleoside with proline NAD+ coenzyme A folate transformations I acyl carrier tRNAphe phosphatidyl- CoA an oxidized trp tetrahydrobiopterin in tRNA related related neurosporene substrate tyr lys Mg2+ a cytochrome c cys DNAn semialdehyde lipoyl-domain pathway synthase, monoacylglycerol GMP fatty an acyl-[acp] ATP hemoprotein 5’-phosphate guanine ITP ribosomal NAD+ D-ribosyl carotene [acp] [acp] alpha-tubulin [acp] [acp] cytidine34 protein]- triphosphate in the third protein 15,16- A2: PLA2G12A 1D-myo- quinone quinone mRNA 4-amino-4- tRNAphe a phosphatidylcholine protein L11 acceptor L-cysteine position Formate-- metabolism mitochondrial: FPGS dihydrobiliverdin a 1- a 1- inositol 5- acyl-[acp] tetrahydrofolate deoxychorismate [+ 2 isozymes] a fatty acid phosphatidyl- phosphatidyl- Putative Nitrate Putative tRNA Sulfite oxidase, Zeta- Zeta- Magnesium- Probable Lipoyl synthase, tetrahydrofolate phosphate Histidinol Pyridoxamine Ribonuclease H2 DNA- ligase: THFS an oxidized an N10-formyl- 1D-myo- 1D-myo- Enoyl-[acyl- Enoyl-[acyl- peroxisomal Probable reductase Indoleamine pterin-4-alpha- Ribosomal (guanine(37)-N1)- mitochondrial: carotene 3-oxoacyl- carotene Tubulin-- 3-oxoacyl- tRNA(Ile) chelatase Probable Probable ORF: methylmalonate- apicoplast: lipA thioredoxin Phycoerythrobilin:ferredoxin urate dehydrogenase: 5’-phosphate subunit A putative: directed glutathione 10-formyl- tetrahydrofolate inositol 3- inositol 4- Guanylate carrier- carrier- Kinesin- acyl-coenzyme bifunctional [NADH] Probable guanine 2,3- Inosine triphosphate carbinolamine protein L11 Poly [ADP- methyltransferase: Suox desaturase: [acyl-carrier- desaturase: tyrosine [acyl-carrier- -lysidine subunit cytochrome cysteine evm.model.contig03842.1 semialdehyde Lipoyl synthase, a holo-[acp] Branched-chain- a 5,10-methylene- stigmasterol hisD oxidase-related DNA/RNA redox tetrahydrofolate a tetrahydrofolate- oxidoreductase: pebB phosphate phosphate kinase: Guk1 protein] protein] like protein A oxidase P-450/ 1: NIA1 deaminase: dioxygenase pyrophosphatase: dehydratase: methyltransferase: ribose] PITG_12867 Probable crtQ protein] crtQ AlNc14C123G6738 ligase-like protein] synthase: ChlD: chlD c-type heme desulfurase, Serine/ dehydrogenase mitochondrial: amino-acid tetrahydrofolate Histidine FMN-binding: Ribonuclease polymerase glutamate a 1- Guanylate reductase reductase KIFC3: 1.2: ACX1.2 NADPH- Nitrate reductase SPCC1672.03c family At4g13720 Plav_1388 prmA polymerase tRNA sulfite oxidase, Zeta- synthase Zeta- protein synthase tilS Magnesium- lyase: cchl mitochondrial: threonine- [acylating], reactions I PITG_14852 aminotransferase- biosynthesis Esi_0074_0067 Z: rnz mu: Polm Bifunctional Probable monoacylglycerol kinase: Guk1 [NADH] [NADH] KIFC3 Peroxisomal P450 [NADH], clone Guanine protein: BNA2 Inosine triphosphate Putative Ribosomal 16: Parp16 (guanine(37)-N1)- mitochondrial: carotene 2: fabF carotene 12: TTLL12 2: fabF tRNA(Ile) chelatase Probable CG12264 protein mitochondrial: like protein 3, (3Z)- trifunctional Pyridoxine/ DNA- glutathione protein folC: folC Bifunctional met methionine-- FabI: fabI FabI: fabI [+ 147 isozymes] acyl-coenzyme reductase PBNBR1412: deaminase: Indoleamine pyrophosphatase: pterin-4-alpha- protein L11 methyltransferase: CG7280 desaturase: [+ 2 isozymes] desaturase: [+ 3 isozymes] [+ 2 isozymes] -lysidine subunit cytochrome Probable phosphatase mmsdh chloroplastic: phycoerythrobilin a phosphatidylcholine a 1-lysophosphatidylcholine protein: HIS4 directed disulfide a lipoylated Thioredoxin [+ 2 isozymes] tRNA ligase: Enoyl-[acyl- Enoyl-[acyl- A oxidase 2: cypE NIA2 pyridoxamine 2,3- carbinolamine methyltransferase: PITG_12867 crtQ crtQ synthase: H: bchH c-type heme cysteine 2A activator: Methylmalonate At5g57850 protein folC: folC Monoglyceride 5’-phosphate guaD PITG_03601 DNA/RNA protein reductase L-aminoadipate- [+ 2 isozymes] Os06g0508700 SECONDARY METABOLITES DEGRADATION carrier- carrier- 1: Acox1 [+ 2 isozymes] dioxygenase dehydratase: prmA a ADP- RNase II tilS lyase: cchl-1 desulfurase: Ppp2r4 semialdehyde lipase: Mgll an L-1- oxidase: pdxH an electron- a 3-oxo- an electron- substrate a 3-oxo-cis- polymerase lipoyl-domain Bifunctional 5,10- 2: trxr2 [+ 3 isozymes] L-methionyl- GDP protein] protein] 1: Ido1 CT0342 D-ribosyl nicotinamide N1- Fe2+ csd dehydrogenase semialdehyde [+ 3 isozymes] transfer- hexanoyl- a holo-[acp] transfer- AMP alpha-tubulin vaccenoyl- a holo-[acp] Mg- protein an N10-formyl- tRNAmet phosphatidyl- reductase reductase nitrate his methylguanine37 with no mu: Polm a tripeptide [acylating] 1: iolA1 methenyltetrahydrofolate Thioredoxin dehydrogenase- 4-aminobenzoate thio- ADP trans-oct-2- xanthine acceptor prolycopene prolycopene [acp] protoporphyrin FolD: folD tetrahydrofolate a 5,10-methylene- inositol a reduced a methylated related [acp] related poly-A tail a [tRNAIle2]- an with proline reductase 2, phosphopantetheinyl tRNAmet [NADH] [NADH] IMP ribosomal in tRNA protoheme IX a [ThiI sulfur- a peptide Glutathione Glutathione Methionine Methylenetetrahydrofolate tetrahydrofolate tetrahydrofolate molybdenum enoyl-CoA pyridoxal-P quinol quinol 2-lysidine34 mitochondrial: transferase: aasdhppt glycerol betanidin 1: fabI1 1: fabI1 hemoprotein N-formylkynurenine dihydrobiopterin apocytochrome c ala at the third reductase: gsr synthase: mtr Serine Methenyltetrahydrofolate protein L11 carrier protein]-S- DNAn propanoyl- peroxidase dehydrogenase [NAD(+)]: thfA Txnrd2 [+ 2 isozymes] salvage from 5,10- cofactor Glycerophosphodiester position NADH 1: GPX1 Glutathione hydroxymethyltransferase synthase domain- degradation DIMBOA- sulfanylcysteine CoA 2: shmt2 methenyltetrahydrofolate NAD biosynthesis phosphodiesterase a trans- a trans- [+ 3 isozymes] reductase: gsr containing protein: mthfsd glucoside delta2- delta2- [+ 3 isozymes] [+ 2 isozymes] molybdenum domain-containing 5,10- phosphorylation and degradation enoyl- enoyl- cofactor protein 1: GDPD1 betanidin methenyltetrahydrofolate dephosphorylation a phosphatidylcholine a 1,2-diacylglycerol DIMBOA- acyl-[acp] acyl-[acp] fatty acid beta-oxidation II (core pathway) beta-D- 5-formyl- a reduced Lysine- tetrahydrofolate an apo-[acp] glutathione NAD+ Molybdenum tRNAlys glucoside Methylenetetrahydrofolate thioredoxin -tRNA Putative L- 5-methyl- 5,10- cofactor 3beta-hydroxy- 3-[(3aS,4S,5R,7aS)- 5-hydroxy-3- beta-D- N4-{N-acetyl-beta-D- glutathione reductase 1: MTHFR1 redox ligase: Kars a [protein]- a mitochondrial beta-D- UDP-alpha- tetrahydrofolate methylenetetrahydrofolate di-trans,poly- sulfurase: a trans-2-enoyl-CoA ascorbate Beta- a 2,3,4- 7,8-dihydrofolate 4beta-methyl- 5-hydroxy-7a-methyl- [(3aS,4S,5R,7aS) 5,6- preprotein glucuronosyl- glucosaminyl-(1,2)- beta-D- [+ 2 isozymes] reactions II peroxidase saturated a palmitoyl- adenosine 3’,5’- pyridoxine- L-beta- N-acetyl-L- a sulfur L-asparaginyl- O-succinyl-L- xylopyranosyl- N-acetyl-D- geranyl cis- MOCOS [+ 3 isozymes] L-lysyl- glucosidase D-tryptophan monoglutamate 5alpha- 1-oxo-octahydro- -7a-methyl-1,5- dihydrouracil20 glt cys including a L-allo- cys (1->3)-beta- alpha-D-mannosyl- mannosyl- Probable 6: APX6 ATP fatty [acp] ATP bisphosphate 5’-phosphate ATP GDP isoaspartate ppGpp ornithine acceptor GTP ADP-ribose threonine ATP selenate tRNAasn homoserine (1->4)-beta-D- coenzyme A ATP octanoate [glycoprotein] glucosamine diphosphate 10-formyl- Molybdenum tRNAlys 6: BGLU6 ATP cholest-7- 1H-inden-4-yl]-3- dioxo-octahydro- in tRNA UDP-alpha- D-galactosyl- (1,3)-[N-acetyl-beta-D- undecaprenyl NAD kinase 2, NAD(P) mitochondrial xylopyranosyl- glutathione tetrahydrofolate cofactor [+ 6 isozymes] acyl-[acp] ene-4alpha- hydroxypropanoyl- 1H-inden-4- targeting N-acetyl-D- (1->3)-beta- GDP-L- glucosaminyl-(1,2)-alpha- biosynthesis phosphate chloroplastic: transhydrogenase, lys Dihydrofolate (1->4)-beta-D- sulfurase: Putative long-chain- Pyridoxamine carbaldehyde Protein-L- CoA yl]propanoyl-CoA sequence xylopyranose- glucosamine D-galactosyl- fucose D-mannosyl-(1,6)]-beta-D- Putative Purple acid Os11g0191400 mitochondrial: NNT ABA3 fatty acid beta- Probable enoyl- Enoyl-[acyl- Enoyl-[acyl- Indoleamine reductase: Probable tRNA- Arginine Probable L-allo- Peptidyl-tRNA Probable isopentenyl (2E,6E)-biosynthesis fatty-acid--CoA Putative peroxisomal betanidin DIMBOA 3’(2’),5’- 5’-phosphate isoaspartate(D- oligosaccharide (1->4)-beta- mannosyl-(1,4)-N-acetyl- uncharacterized menaquinol-6 Bifunctional phosphatase NADH kinase: a 2,3,4-saturated acyl-coenzyme A CoA hydratase, Soluble carrier- Probable 2,3- Nucleoside Trifunctional dihydrouridine biosynthesis cysteine ADP-ribose Mitochondrial- threonine Sulfate hydrolase 2, cystathionine Putative farnesyl oxidation III coenzyme A ligase: HI_0002 quinone carrier- Uncharacterized bisphosphate Rmar_0341 Methylsterol aspartate) O- Sterol-4-alpha- Guanosine-3’,5’- Uracil- D-xylosyl- beta-D-glucosaminyl- diphosphate menaquinol-8 21: PAP21 NADK3 fatty acid calcium- protein] dioxygenase Bifunctional oxidase-related synthase 2: dus2 bifunctional desulfurase, aldolase: mitochondrial: gamma-synthase: protein biosynthesis purine diphosphate thio- [+ 2 isozymes] oxidase 1.2: ACX1.2 mitochondrial: echs1 protein] RNA ABC transporter nucleotidase diphosphate methyltransferase: enzyme bis(diphosphate) 3’- regulated pyrophosphatase: processing adenylyltransferase: Reducing [core protein] acyl-CoA (1,4)-N-acetyl-beta-D- biosynthesis Glutathione biosynthetic [+ 9 isozymes] (unsaturated, activated reductase family dihydrofolate FMN-binding: monooxygenase carboxylate 3- tRNA- protein ArgJ, mitochondrial: ltaA Ptrh2 SPBC15D4.09c B618R: B618R pyridoxal 5’- thiamin molybdenum Peroxisomal reductase helicase ATP-binding CysQ: cysQ Esi_0074_0067 kinase 4, 1: Msmo1 PCMT1 subunit alpha, dehydrogenase, pyrophosphohydrolase: protein nudF peptidase MET3 end xylose- synthetase glucosaminyl}asparagine Beta-1,4-mannosyl- reductase: gsr protein odd number) acyl-coenzyme A nucleotidase [NADH] [NADH] SDE3: protein/permease protein: BNA2 reductase- chloroplastic: mitochondrial: dihydrouridine(20) mitochondrial: CG12264 1: urg1 ADP-ribose subunit L-allo- Bifunctional 3’- Peptidyl-tRNA Cystathionine YngI: yngI Farnesyl phosphate salvage III Undecaprenyl cofactor Histidine-- a 2,3,4-saturated a (3S)-3- SAL1 Pyridoxine/ Methylsterol Protein-L- decarboxylating: spoT releasing exo- glycoprotein 4-beta-N- demethylmenaquinol-6 Glutathione purD: purD a cis-3- oxidase 1: Acox1 1: Cant1 FabI: fabI 1: fabI1 SDE3 Indoleamine thymidylate NDK4 HADHA synthase [NAD(P) PITG_04698 Probable [+ 2 isozymes] pyrophosphatase: alpha: MPP threonine phosphoadenosine hydrolase 2, gamma- Xylosyltransferase Medium- diphosphate pyrophosphate tRNA ligase, fatty acyl CoA hydroxyacyl-CoA YOL075C: phosphatase: pyridoxamine monooxygenase isoaspartate(D- Nsdhl Guanosine-3’,5’- oligoxylanase: Alpha-(1,3)- acetylglucosaminyltransferase: biosynthesis II demethylmenaquinol-8 reductase: gsr his enoyl-CoA Trifunctional enzyme Enoyl-[acyl- Enoyl-[acyl- [+ 128 isozymes] YOL075C/ 2,3- synthase [+ 2 isozymes] [+ 2 isozymes] +]-like: Dus2l bis(diphosphate) 3’- cysteine nudF [+ 4 isozymes] aldolase: 5’-phosphosulfate mitochondrial: synthase: metB BH2105 1 (Fragment): Xylt1 chain-fatty- fucosyltransferase: synthase: fps synthase: uppS cytoplasmic: SAL1 5’-phosphate 1: Msmo1 aspartate) O- 2,5-diamino-6- Mgat3 subunit alpha, carrier- carrier- YOL074C dioxygenase 2: THY-2 3-[(3aS,4S,7aS) desulfurase: ltaA synthase 2: PAPSS2 PTRH2 [+ 2 isozymes] acid--CoA FUT4 [+ 6 isozymes] thiamin hars oxidase: pdxH methyltransferase: 3-[(3aS,4S,5R,7aS) pyrophosphohydrolase: (5-phospho-D- Reducing D-ribose-5- D-glyceraldehyde- tetrahydrofolate mitochondrial: HADHA protein] protein] 1: Ido1 3beta- -7a-methyl- N-acetyl-L- csd ligase: alkK gln Ubiquinone/ di-trans,octa- [+ 3 isozymes] Enoyl-CoA delta [+ 152 isozymes] PCMT1 -5-hydroxy-7a- spoT L-ornithine a processed end xylose- Glycoprotein phosphate 3-phosphate Ubiquinone/ L-histidyl- [+ 2 isozymes] AMP reductase reductase hydroxy- 1,5-dioxo- uracil20 glutamate ribosylamino) formate succinate L-cystathionine alpha-N- 4-(N-acetyl- menaquinone cis- NADP+ isomerase 2, anandamide methyl-1-oxo- mitochondrial a peptide releasing exo- 3-alpha-L- menaquinone tRNAhis [NADH] tetrahydrofolate a protein octahydro- in tRNA pyrimidin- D-ribose-5- adenosine 5’- beta-D- geranyl biosynthesis glutathione undecaprenyl degradation [NADH] ADP N-formyl-D- AMP GTP ADP 4beta-methyl- octahydro-1H- AMP protein gly acetaldehyde asn tRNAasn oligoxylanase: acetyl-D- fucosyltransferase Thiamin mitochondrial: 1: fabI1 pyridoxal-P 5alpha- L-beta- 1H-inden-4- S-sulfanyl- 4(3H)-one phosphate phosphoselenate glucosaminyl- UDP glucosaminyl) diphosphate methyltransferase biosynthesis diphosphate tRNAhis FabI: fabI ala BH2105 A: FUT11 Pyridoxal pyrophosphokinase methyltransferase disulfide adenosylcobalamin Eci2 kynurenine isoaspartate inden-4-yl]-3- yl]propanoyl- [acceptor] octanoyl- -beta-D- ubiE: ubiE ADP cholest-7- oxopropanoyl-CoA GDP (1->4)-beta-D- AMP biosynthesis 1: TPK1 ubiE: ubiE salvage from alpha- CoA beta-D- CoA mannosyl- [+ 3 isozymes] anandamide a trans- a trans ene-4alpha- glucuronosyl- N(4)-{N-acetyl-beta- lyase pdxS: pdxS [+ 3 isozymes] a trans-2- a 2,3,4-saturated delta2- carboxylate methyl ester xylopyranosyl- (1->3)-beta- [glycoprotein] cobalamin a 3-oxoacyl-CoA hexadecenoyl- beta-D- UDP D-glucosaminyl-(1,2) enoyl-CoA fatty acyl CoA enoyl- xylopyranose (1->4)-beta-D- D-galactosyl- -alpha-D-mannosyl- thiamin [acp] xylopyranose- diphosphate menaquinol-6 cob(I)alamin Fatty-acid amide acyl-[acp] (1->3)-beta- (1,3)-[N-acetyl-beta-D- menaquinol-8 oligosaccharide D-galactosyl- pyridoxal-P Glycine-- hydrolase 1: FAAH glucosaminyl-(1,2)-alpha- tRNA ligase 1, Fatty-acid amide (1->4)-beta- D-mannosyl-(1,6)]-beta-D- GDP Cob(I)yrinic mitochondrial: hydrolase 1: FAAH D-xylosyl- mannosyl-(1,4)-N-acetyl- acid a,c-diamide gly GLYRS-1 3-ketoacyl-CoA thiolase, [core protein] beta-D-glucosaminyl- adenosyltransferase, Glycine- mitochondrial: ACAA2 (1,4)-[alpha-L-fucosyl- mitochondrial: Mmab -tRNA arachidonate ethanolamine (1,3)]-N-acetyl-beta-D- ligase: glyQS glycyl- glucosaminyl}asparagine tRNAgly coenzyme B12 tRNAgly

This diagram was automatically generated by SRI International Pathway Tools version 16.0, authors S. Paley and P.D. Karp. ! Figure 2 Map of the metabolic pathways identified in Nannochloropsis gaditana after genome sequencing and annotation

• A comparative analysis of the genes of Nannochloropsis in relation to the genes of various other algae of the red, brown and green groups has shown that Nannochloropsis has an expanded repertoire of some of the genes involved in triacylglycerol assembly. Most interestingly we found a high number of triacylglycerol lipases, many of them belonging to a gene family which seems to be exclusive to Nannochloropsis. Triacylglycerol lipases can affect lipid metabolism in many ways through triacylglycerol degradation and lipid remodeling. Further studies will be needed to enlighten the function of these genes are their rule in Nannochloropsis metabolism. • We found genes essential for the RNA silencing process and we also found indication that miRNA might be expressed in Nannochloropsis. These findings open interesting perspectives for the genetic manipulation of Nannochloropsis using gene knock-down techniques based on the transient expression of siRNA. • We found genes whose orthologous are annotated as blu-light sensors. Confocal microscopy analysis revealed the presence of red eye-spots in the cells located outside of the chloroplast that could be assigned as a blu-light sensing structure. If these attributions are correct, they open the perspective that a circadian regulation of growth and metabolic activity might be present in this microalga. Such a possibility would not be in contrast with some observations collected in outdoor cultivation plants and has important implication for the exploitation of this organism in production plants.

! 3! Triacylglycerol accumulation in nitrogen scarcity

Upon treating Nannochloropsis cells with a substance that stains specifically the neutral lipids (Nile Red) we can observe that in nitrogen deprivation (-Nitrate) they accumulate big lipid droplets (yellow signal) usually not present in the cells grown in the presence of nitrogen (+Nitrate). Comparison of the abundance of the transcripts in the cultures with sufficient nitrogen and poor lipid accumulation and in the cultures with scarce nitrogen and high lipid accumulation, offered the possibility to delineate the activation and the tuning down of Figure!3!Confocal!microscopy! various metabolic pathways and to hypothesize the images!of!Nannochloropsis!cells.!In! balancing of the fluxes responsible for the red!the!chlorophyll,!in!yellow!the! accumulation of triacylglycerols inside the lipid lipid!droplets.!From!11Corteggiani! droplets in nitrogen deprivation. Carpinelli!et!al!2014

The analysis of the gene expression revealed that Nannochloropsis activated various mechanisms of nitrogen assimilation and redistribution in nitrogen scarcity and survived thanks to a partial reorganisation of its cellular metabolism. Various genes whose function is related to controlled protein degradation were induced in nitrogen stress, together with genes coding for proteins involved in the formation of cytosolic sequestering vesicles, which are used for degradation and recycling of cellular components. The up-regulation of these degradative processes made aminoacids available for biosynthetic processes without the need of nitrogen input (which is normally needed for the synthesis of new aminoacids). In addition various degradative processes that release ammonium were also found over- expressed. The GS/GOGAT pathway (L-glutamine + 2-oxoglutarate + NADPH + H+ ←→ 2 L-glutamate + NADP+) was activated in the nitrogen-deprived cells. The enzymes of this pathway are: glutamine synthetase (GS), which has a high affinity for NH3 and catalyzes the incorporation of ammonia into glutamine; glutamate synthases and glutamine amidotransferase, which are able to transfer one amino group from glutamine to 2-oxoglutarate and release, as a result, two molecules of glutamic acid. The glutamic acid produced through this pathway is an available substrate for further incorporation of intracellular ammonia and represents also a source of amine groups for cellular biosynthetic processes. I therefore hypothesize that this glutamine–glutamate shuffle might act as a central intermediary of amine groups’ exchange between degradative and biosynthetic pathways.

! !

Figure! 4! Schematic! representation! of! the! reorganization! of! the! cellular! metabolism! in! Nannochloropsis!in!nitrogen!scarcity!as!deduced!from!RNA

! 4! The genes predicted to function in the biosynthetic processes were still actively expressed at high levels for at least for 2-3 days after nitrogen deprivation with the exception of those responsible for protein biosynthesis of the organelles, which were instead severely tuned down even during early nitrogen deprivation. In response to nitrogen deprivation, the cells reorganized their metabolism by degrading selectively unnecessary molecules and synthesizing new ones to allow survival even in the deficiency of a fundamental nutrient and the first activities that were tuned down were those that take place in the organelles. ! The transcriptomic data showed that the genes involved in fatty acid and triacylglycerol biosynthesis were always abundant in the cells (both when nitrogen was available and when it was deficient) and that their expression was not correlated with the amount of oil accumulated in the cells. Also the expression of the genes involved in lipid degradation did not seem to change significantly. The general conclusion suggested by the experimental evidence was that Nannochloropsis constitutively synthesized lipids and that the metabolic reorganization that followed nitrogen deprivation increased the flux of substrates through the lipid biosynthetic pathways, which were in turn capable to sustain the increased metabolic flux. Based on the available data I proposed a model of the metabolic response of Nannochloropsis to nitrogen deficiency that could justify an overproduction of fatty acids and as a consequence an accumulation of oil.

! Figure 5 Potential Model of the flux trough the fatty acid synthesis pathways in nitrogen sufficient and nitrogen deficient culturing conditions based on transcriptomic data. P, plastid; M, mitochondrion; L, lipid droplet.

Simionato et al. showed that despite the decrease of photosynthetic yield, photosynthesis is the only energy supply of the cells in nitrogen starvation. One of the most evident effects of nitrogen starvation that we noticed was the deescalation of the organelles. The model therefore states that the energy came into the system through the photosynthetic activity of the chloroplasts in both nitrogen sufficient and nitrogen depleted cultures, and produced glucose. After degradation of the glucose by glycolysis (the genes of this pathway were expressed at similar levels in both the two culturing conditions) the Acetyl-CoA and the reduced NAD(P)H were mainly reoxidised through the Krebs cycle and the mitochondrial respiration in nitrogen sufficient cultures. Only a small fraction of the Acetyl-CoA and of the reduced NAD(P)H entered the fatty acid biosynthetic pathway in this condition. During nitrogen starvation, due to the severe down-regulation of the mitochondrial genes, the reoxidation of the Acetyl-CoA and of the reduced NAD(P)H became less efficient and more substrates were available to enter the fatty acid biosynthetic pathway,

! 5! leading to the accumulation of oil into the lipid droplets. This interpretative model was tested experimentally using various inhibitors of the mitochondrial respiratory chain in nitrogen sufficient cultures and measuring the average amount of intracellular lipids of the growing cells. The results were encouraging but not conclusive because of the scarce uptake of the inhibitors by Nannochloropsis cells. According to this model the mitochondrial complex I subunits would be interesting targets for genetic modification aimed at increasing the lipid productivity of the cultures. ! A web resource of Nannochloropsis to support research While the production of data has become faster and cheaper, the necessity to fully analyze, organize and share them has become more pressing. I was deeply persuaded that the community of biochemists, biotechnologists and physiologist that worked with Nannochloropsis would have gained a lot of utility from the full access to the sequences of the genes and chromosomes, as well as to the metabolic and functional annotation and to the gene expression analysis in a format that could be accessible to anyone without the need of specific informatics skills. Thanks to the great resources of the bioinformatics group of the Functional Genomic Research Unit it was possible to developed a comprehensive bioinformatic platform for information retrieval and data analysis, which is available online at www.nannochloropsis.org. The platform integrates several resources: a quick search engine that, upon the input of a gene ID or Figure!6!Screenshot!of!the!home!page!of!the! function, returns the complete Nannochloropsis!web!platform! characterization of the gene, its sequence, and its genomic context; a query system that allows the user to obtain all the available information concerning a gene or a group of genes that correspond to the criteria used for the research (e.g. level of expression or enzymatic function); a genome browser displaying the annotation and the level of expression of each gene in different experiments; a blast search engine; a database of the metabolic pathways elaborate using the pathway tools framework and a scientific blog.

Three months after the platform was made available on the web, it had more than 1000 unique visitors per month and the number of pageviews has been steadily growing since then.

My personal view of this scientific experience The Nannochloropsis project has represented the most complete and autonomous research experience of my early carrier as research scientist. It has allowed me to cultivate my scientific interest for metabolic biochemistry, it was the first scientific project that I had the possibility to conceive and it has been a nice teamwork experience thanks to many excellent colleagues and students. All the work was characterized by a lively curiosity, a motivational commitment and a lot of creativity.

! 6! ! Metagenomics One of the first applications of the next generation sequencing technologies to sparkle my interest was metagenomics. Throughout immeasurable time, microorganisms have evolved and accumulated remarkable physiological and functional heterogeneity, and now constitute the major reserve for genetic diversity on earth. Cultivation-independent assessment of microbial genomes offers a major resource for observing the pallet of the different metabolic strategies; furthermore, this material is a major asset in the search for new enzymes for various industrial processes. Currently, there is a global political drive to promote industrial biotechnology as a central feature of the sustainable economic future of modern industrialized societies. This requires the development of novel enzymes, processes, products and applications. Metagenomics might represent an important resource for finding new molecules with diverse functions.

During my Post-Doc at CRIBI in the group of Genomics, while collaborating on various projects of the group (including the realization of a metabolic pathways database of Vitis vinifera) I was given the possibility to design and realize a metagenomic experiment together with my colleague Andrea Telatin. The experiment had to fulfill the task of testing the performances of the Ion Proton sequencer on amplicons, whole metagenomes and ribosomal RNA fragments. We identified an interesting ecosystem, the Canale Scaricatore in Padova. This river crosses for a short trait an industrial area and collects various pollutants. We collected various water samples from the polluted area and we set up an innovative protocol to extract both total DNA and RNA at the same time in order to allow a more significant comparison of the sequencing data. I also prepared the sequencing libraries and we worked together on the analysis of the sequencing data testing various available software tools. The sequences produced by this first run of Ion Proton resulted too short and too few to support significant conclusions. Nevertheless we noticed the presence of various bacteria capable to degrade toluene and benzene derivatives and we focused our attention on the search of their genomic sequences in order to gain some information about possible enzymes of interest.

Despite the poor biological conclusions that we were able to reach using the available data, this scientific experience was of great interest for the two of us. Indeed we were very happy to try ourselves at this new task and to earn some technical instruments useful for metagenomic analysis, which we both hope to use again in the future.

! 7! Photosynthesis I carried out the research project for my Second Level Degree in the research unit of Photosynthesis of Professor James Barber at Imperial College in London. During my stay in the laboratory I focused my efforts in the purification of functional Photosystem II (PSII) complexes from various cultures of Synechocystis PCC 6803 in which the PSII was present in relatively small amounts (i.e. from cultures grown in iron depletion and from strains with mutations effecting PSII subunits). The result of my efforts was the successful purification of functional and relatively pure PSII complexes from the iron-depleted cultures and from the mutant cultures of Synechocystis. The analysis of the particles of PSII obtained from the iron depleted cultures revealed that the Photosystem II did not undergo structural or functional changes upon iron deprivation differently from PSI, which in iron scarcity was surrounded by an extra antenna giving rise to a PSI-antenna supercomplex. According to the evidence that we produced the absence of iron was affecting only the amount of Photosystem but not its structural or functional characteristics. It is during this experience in the laboratory of James Barber that I acquired much of my knowledge about photosynthesis and the lot of my abilities as scientist. The beginning of my interest for renewable energies and for artificial photosynthesis also dates back to that period and to the interesting discussions with the scientists with whom I came in touch. During the first two years of my PhD training a continued working on photosynthesis, this time in the laboratory of Professor Giorgio Giacometti at University of Padova. My work in Padova was mainly focused on the regulative aspects of the photosynthetic process and I was involved in various projects of the group. The most of my research was concentrated on the study of peroxidase activities in the thylakoid lumen. ! ! ! ! !

! 8! Teaching During my PhD and Post-Doc I had an intense activity as Teaching Assistant in molecular biology, biochemistry and genomics and I was also given the responsibility of tutoring some Undergraduate Students during their Graduation Projects. Despite teaching in Academia is not strictly a research experience I found it relevant to include a short paragraph about this activity in my report. My research interests indeed have both shaped and been shaped by my experiences as teacher, especially in the design of the laboratory activities. The activity as teacher has been often the occasion for me for great experimentations, both for the scientific topics that I chose to examine and for the abilities that I had the chance to test and improve. When I organized my first laboratory class of metabolic biochemistry I decided to include a simple experience about photosynthesis, which I was very confident to carry out with enthusiasm and competence, and a second experience about the measuring of the ATP production of isolated mitochondria, which I had never done before but I had been willing to observe for a long time. Choosing the topics for the tutorials and exercises of metabolic biochemistry I allowed myself to study something about diets and human metabolism during one academic year and about the industrial applications of various strains of bacteria during another. I once agreed to organize a laboratory experience of metagenomics for the students of the course of genomics in order to enjoy also myself for the first time working on a project in this interesting field. To my delight both the students and me were able to learn a lot from that laboratory experience. Working in the didactic laboratories gave me the opportunity to collaborate with many different colleagues and to have various roles. Being responsible of conceiving and organizing in various occasions the didactic laboratories was a good training for learning how to manage a project and how to coordinate the work of a group of people. Teaching was a great opportunity to improve my communication skills and was also the occasion for testing various instruments. It is during my laboratory classes indeed that I decided to exploit the potential of web pages and blogs for science communication for the first time. In Figure 7 I show the screenshot of a blog that I’ve used for a few years with the students of metabolic biochemistry and that other teachers often visit. I have recently tested the video-tutorials as useful tools to integrate the lectures and I am still studying and practising to improve my capability of producing good quality videos as well as useful illustrations. ! Figure 7 Screenshot of my blog about metabolic biochemistry, used by students and by other teachers

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