Rnascope® Probes for Cancer Research Get Probes for Your Gene of Interest Designed and Manufactured in Two Weeks

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Probe List Series Cancer Research

RNAscope® Probes for Cancer Research Get probes for your gene of interest designed and manufactured in two weeks.

Featured Publications using Cancer RNA Biomarkers RNAscope® Technology A cancer RNA biomarker refers to a coding or Increased expression of the noncoding RNA that is indicative of the presence of immune modulatory molecule cancer—either expressed by a tumor or expressed PD-L1 (CD274) in anaplastic as a specific response of the body to the presence meningioma. of cancer. Cancer researchers apply RNAscope® in Du et. al. Oncotarget. 2014 Dec 31. PMID: 25609200 situ hybridization to study the following: Tumor heterogeneity—There is a tremendous A Novel RNA In Situ Hybridization amount of inter-tumor and intra-tumor Assay for the Long Noncoding heterogeneity. The RNAscope® assay’s single- RNA SChLAP1 Predicts Poor molecule sensitivity with single-cell resolution Clinical Outcome After Radical Prostatectomy in Clinically along with intact morphological context allows for FIGURE 1. PECAM1 (red) and EGFR (green) expression in human Localized Prostate Cancer. visualization of differential gene expressions in breast cancer FFPE tissue using the RNAscope® 2-plex morphologically similar tumor cells. Mehra R. et. al. Neoplasia (2014) Chromogenic Kit PMID: 25499224 Tumor microenviroment—A tumor is a complex Novel RNA Hybridization Method organ comprised of many different cell types. for the In Situ Detection of ETV1, Its communication with neighboring normal cells, ETV4, and ETV5 Gene Fusions in extracellular matrix, and signaling molecules Prostate Cancer. like chemokines, cytokines and growth factors Kunju et. al. is a major driver of cancer progression and Appl Immunohistochem Mol metastasis. RNAscope® ISH is particularly suited Morphol. 2014 Sep;22(8):e32-40. for dissecting complex autocrine and paracrine PMID: 25203299 communication mechanisms.

See more publications at Circulating tumor cells—The unprecedented acdbio.com/publications high-fidelity signal amplification and multiplexing capability of RNAscope® technology make it possible to simultaneously detect and characterize viable CTCs in the background of FIGURE 2. PanCK, uPA and PAI-1 mRNA expression in human millions of blood cells. breast cancer FFPE tissue using RNAscope® Fluorescent Multiplex Assay RNAscope® ISH enables visualization of RNA biomarkers while preserving tissue context with single-cell resolution. It is an essential solution in a multitude of cancer research applications including risk assessment, diagnosis, prognosis, patient stratification, therapy and epidemiology.

Visualize RNA biomarkers in your cancer tissues today www.acdbio.com/cancer RNAscope® Cancer Genes Probe List Probe details are available at www.acdbio.com/probesearch

Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 432291 Hs-ABCA1 445951 Hs-AR-Intron8 410241 Hs-CALCA 419341 Hs-CD79B 401191 Hs-ABCB1 401221 Hs-AR-V*E 446241 Hs-CAMP 421471 Hs-CD80 417461 Hs-ABCB4-opt-cust 313111 Hs-AREG 419311 Hs-CARD11 430341 Hs-CD86 435591 Hs-ABCC1 408331 Hs-ARexon1 436561 Hs-CASP3 560391 Hs-CD8A 448221 Hs-ABCC11 401581 Hs-ARG1 409371 Hs-CASP8 430671 Hs-CD9 422321 Hs-ABCC4 416251 Hs-ARHGAP35 411931 Hs-CASR 559231 Hs-CDA 422721 Hs-ABCG2 538341 Hs-ARID1A 419321 Hs-CBFB 422691 Hs-CDCP1 404701 Hs-ACACA 419231 Hs-ARID2 431331 Hs-CBS 311091 Hs-CDH1 441451 Hs-ACKR3 419241 Hs-ARID5B 539041 Hs-CCK 310171 Hs-CDH2 427121 Hs-ACP5 419251 Hs-ASXL1 311101 Hs-CCKBR 407201 Hs-CDH3 310141 Hs-ACTB 419261 Hs-ASXL2 423811 Hs-CCL2 451551 Hs-CDH5-No-XMm 419191 Hs-ACVR1B 405741 Hs-ATF4 409611 Hs-CCL20 419351 Hs-CDK12 559661 Hs-ADAM10 419271 Hs-ATM 549171 Hs-CCL5 419361 Hs-CDK4 432561 Hs-ADAM12 442611 Hs-AURKA 591821 Hs-CCND1 311401 Hs-CDKN1A 435811 Hs-ADAM9 400241 Hs-AXIN2 438221 Hs-CCR2 607061 Hs-CDKN1B 450641 Hs-ADRB2 602131 Hs-AXL 426851 Hs-CCR4 408201 Hs-CDKN1C 427411 Hs-AFP 445101 Hs-A XL- O1 601501 Hs-CCR5 310181 Hs-CDKN2A 602841 Hs-AGTR1 401861 Hs-AZGP1 403911 Hs-CCR6 447331 Hs-CDKN2A-No-XMm 447421 Hs-AHSG 310161 Hs-B2M 409621 Hs-CCR6-3UTR 417661 Hs-CDKN2B-AS1 521761 Hs-AICDA 419281 Hs-BAP1 410721 Hs-CCR7 406261 Hs-CDX2 419201 Hs-AJUBA 407731 Hs-BBC3 418801 Hs-CD14 451451 Hs-CEACAM5 419211 Hs-AKT1 591721 Hs-BCL2 417061 Hs-CD163 403031 Hs-CEACAM6 434211 Hs-AKT3 408271 Hs-BCL2L1 416391 Hs-CD1D 419371 Hs-CEBPA 600941 Hs-ALB 407251 Hs-BCL6 407361 Hs-CD22 416191 Hs-CEP76 310151 Hs-ALDH1A1 416321 Hs-BCLAF1 313021 Hs-CD24 404361 Hs-CES2 311841 Hs-ALK 419291 Hs-BCOR 415451 Hs-CD27 317551 Hs-cFLIP-L 314731 Hs-ALK-E1-E18 319931 Hs-BCR 415461 Hs-CD27-sense 317561 Hs-cFLIP-S 314191 Hs-ALK-E19-29 452121 Hs-BCR-sense 600861 Hs-CD274 428731 Hs-CFH 317841 Hs-ALK-E19-E29-20P 409041 Hs-BDNF-CDS 316271 Hs-CD274-sense 603291 Hs-CFTR 405671 Hs-ALOX12 434111 Hs-BECN1 430411 Hs-CD276 419381 Hs-CHD4 420171 Hs-ALOX15B 419301 Hs-BHMT2 448871 Hs-CD28 416261 Hs-CHD8 416181 Hs-ALPK2 418611 Hs-BIK 310831 Hs-CD30 427821 Hs-CHEK1 431111 Hs-ALPL 560311 Hs-BIN1 560821 Hs-CD34 311111 Hs-CHGA 447961 Hs-ALPPL2 562551 Hs-BIRC7 451511 Hs-CD34-No-XMm 408121 Hs-CHI3L1 405451 Hs-AMACR 591931 Hs-BMI1 555241 Hs-CD38 310101 Hs-CHRNA7 594511 Hs-ANGPT2 430641 Hs-BMP2 605601 Hs-CD4 418721 Hs-CIITA 439021 Hs-ANO1 424401 Hs-BMP7 408061 Hs-CD4-40LE-FL 310201 Hs-CK17 419221 Hs-APC 595251 Hs-BRAF 578471 Hs-CD40 310211 Hs-CK18 314311 Hs-APOA1 485471 Hs-BRCA1 542341 Hs-CD40LG 310221 Hs-CK19 433091 Hs-APOE 436981 Hs-BRCA1-E11 311271 Hs-CD44 310241 Hs-CK5 404691 Hs-APOH 401371 Hs-BRCA2 430151 Hs-CD46 310261 Hs-CK8 418321 Hs-APP 437011 Hs-BRCA2-E17E18 555111 Hs-CD47 418101 Hs-CLDN18 421831 Hs-AQP1 408431 Hs-BTG2 426551 Hs-CD55 421031 Hs-CLDN3 400491 Hs-AR 438451 Hs-CA2 560591 Hs-CD68 421041 Hs-CLDN4 421371 Hs-AR-E1-E3 559341 Hs-CA9 419331 Hs-CD70 606241 Hs-CLU 401211 Hs-AR-E1*E 422171 Hs-CALB2 425521 Hs-CD70-sense 310051 Hs-CMET

2 Probe List Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 591521 Hs-CNR1 412711 Hs-DLX4 604021 Hs-ERG 406941 Hs-FOXM1 596021 Hs-CNR2 416331 Hs-DNER 310301 Hs-ESR1 407231 Hs-FOXP1 401891 Hs-COL1A1 434621 Hs-DNM1L 311411 Hs-ETV1 418471 Hs-FOXP3 432721 Hs-COL1A2 434831 Hs-DNMT1 491521 Hs-ETV4 419511 Hs-FOXQ1 419391 Hs-CREBBP 419441 Hs-DNMT3A 528941 Hs-EZH1 450681 Hs-FRMD7 426271 Hs-CRYAB 412601 Hs-DPP4-CDS-XMmu 405491 Hs-EZH2 400501 Hs-FSHR 313001 Hs-CSF1 446251 Hs-DPYD 319861 Hs-F2RL1 408101 Hs-FSHR-ver2 310811 Hs-CSF1R 310721 Hs-DR5 407611 Hs-F3 315051 Hs-FTL 433681 Hs-CSF1R-sense 553991 Hs-DRD2 419471 Hs-FAM46C 310321 Hs-GAPDH 313981 Hs-CSF2 440211 Hs-DROSHA 411971 Hs-FAP 442201 Hs-GAPDH-No-XMm 425301 Hs-CSF3 405361 Hs-DUSP6 449051 Hs-FASLG 435261 Hs-GAPDH-O1 424631 Hs-CSMD1 436671 Hs-E2F3-tv1 449061 Hs-FASLG-sense 427811 Hs-GAS6 411041 Hs-CSPG4 443661 Hs-EDNRA 430911 Hs-FASN 403551 Hs-GATA3 402891 Hs-CTAG1B 528301 Hs-EDNRB 419481 Hs-FAT1 579821 Hs-GATA4 419401 Hs-CTCF 408471 Hs-EDNRB-R9 405801 Hs-FBXW7 603131 Hs-GATA6 560581 Hs-CTGF 433161 Hs-EFEMP1 555921 Hs-FCGR2A 600301 Hs-GDF15 554341 Hs-CTLA4 430651 Hs-EFNB2 584671 Hs-FERMT2 437871 Hs-GDNF 311731 Hs-CTNNB1 605771 Hs-EGF 312111 Hs-FGF2 311801 Hs-GFAP 419411 Hs-CUX1 310061 Hs-EGFR 439421 Hs-FGF2-O1 444211 Hs-GHR 411261 Hs-CX3CL1 319461 Hs-EGFR-delta 443441 Hs-FGF7-no-XMm 444281 Hs-GJA1 411251 Hs-CX3CR1 418731 Hs-EGFR-no-X-Mm 422421 Hs-FGF9 310991 Hs-GLI1 403981 Hs-CXADR 438311 Hs-EGFR-tv1 439431 Hs-FGF9-O1 519821 Hs-GLP1R 311851 Hs-CXCL10 428381 Hs-EGFR-tv4 310071 Hs-FGFR1 450361 Hs-GLS 422991 Hs-CXCL12 435831 Hs-EIF4E 443411 Hs-FGFR1-no-XMm 419521 Hs-GNA13 311321 Hs-CXCL13 410611 Hs-ELAVL1 430581 Hs-FGFR1-O1 553421 Hs-GNRHR 425291 Hs-CXCL14 410621 Hs-ELAVL1-sense 311171 Hs-FGFR2 411401 Hs-GNRHR-3UTR 539251 Hs-CXCR3 416401 Hs-ELF3 443421 Hs-FGFR2-no-XMm 411491 Hs-GNRHR-5UTR 310511 Hs-CXCR4 421401 Hs-ENO2 310791 Hs-FGFR3 407991 Hs-GNRHR1-noCXMm 430861 Hs-CYP19A1-O1 431851 Hs-ENO2-O1 436841 Hs-FGFR3-O1 418091 Hs-GPC3 452181 Hs-CYP2E1 601051 Hs-ENPP2 412301 Hs-FGFR4-CDS 413521 Hs-GPNMB 550331 Hs-CYP3A5 419451 Hs-EP300 443431 Hs-FGFR4-no-XMm 433111 Hs-GPR55 412041 Hs-DACH1 410591 Hs-EPAS1 450621 Hs-FIGF-No-XMm 411211 Hs-GPR68 418231 Hs-DAXX 410601 Hs-EPAS1-sense 405281 Hs-FLG 419531 Hs-GPS2 441961 Hs-DCC 310281 Hs-EPCAM 311221 Hs-FLI1 310331 Hs-GRB7 602031 Hs-DCK 407441 Hs-EPHA2 408981 Hs-FLI1-C1-part1 312831 Hs-GREM1 589521 Hs-DCN 406251 Hs-EPHB2 560701 Hs-FLT1 428421 Hs-GRM1 312371 Hs-DDB2 516401 Hs-EPHB4 419491 Hs-FLT3 437731 Hs-GRN 311131 Hs-DDIT3 414201 Hs-EPO 552441 Hs-FLT4 310601 Hs-GUCY2C 593591 Hs-DDR1 312191 Hs-EPOR 310311 Hs-FN1 445971 Hs-GZMB 419421 Hs-DDX3X 413031 Hs-ERAS 425481 Hs-FN1-E33 400771 Hs-H19 400751 Hs-DEFB4A 312671 Hs-ERBB2-FL 310801 Hs-FN14 411911 Hs-HAMP 403051 Hs-DICER1 418741 Hs-ERBB2-no-X-Mm 430541 Hs-FOLH1 560681 Hs-HAVCR2 419431 Hs-DIS3 311941 Hs-ERBB3 580751 Hs-FOLR1 316051 Hs-HAVCR2-sense 421411 Hs-DKK1 407831 Hs-ERBB4 319901 Hs-FOS 524821 Hs-HBEGF 415781 Hs-DKK3 310291 Hs-ERCC1 419501 Hs-FOXA1 431651 Hs-HBEGF-O1 603001 Hs-DLL4 419461 Hs-ERCC2 313201 Hs-FOXC2 448051 Hs-HDAC1

Cancer Research 3 RNAscope® Cancer Genes Probe List (continued) Probe details are available at www.acdbio.com/probesearch

Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 448061 Hs-HDAC2 310351 Hs-IGFBP3 419581 Hs-KDM6A 428021 Hs-MAGEA4 310081 Hs-HER2 316681 Hs-IGFBP7 591611 Hs-KDR 433311 Hs-MAL 311191 Hs-HES1 602051 Hs-IL10 451051 Hs-KDR-No-XMm 400811 Hs-MALAT1 310761 Hs-HGF 316061 Hs-IL10-sense 435371 Hs-KDR-O1 445401 Hs-MAP1LC3A 441421 Hs-HGF-No-XMm 425281 Hs-IL11 419591 Hs-KEAP1 419641 Hs-MAP2K1 435361 Hs-HGF-O1 402061 Hs-IL12A 448271 Hs-KISS1R 419651 Hs-MAP2K4 418701 Hs-HGF-v2d 402071 Hs-IL12B 606401 Hs-KIT 419661 Hs-MAP3K1 605221 Hs-HIF1A 586241 Hs-IL13 407671 Hs-KITLG 603161 Hs-MAP3K5 314331 Hs-HIF1A-3UTR 546221 Hs-IL13RA2 422041 Hs-KL 402751 Hs-MAP3K8 428351 Hs-HLA-DRB1 310931 Hs-IL17A 437321 Hs-KLF10 416271 Hs-MAP4K3 426691 Hs-HLA-G 400301 Hs-IL18 601181 Hs-KLF5 408991 Hs-MAPT 434631 Hs-HMGB1 556791 Hs-IL1A 555151 Hs-KLK3 414041 Hs-MAX 319851 Hs-HMOX1 310361 Hs-IL1B 448801 Hs-KLK5 416341 Hs-MBD1 442921 Hs-HNF4A 441601 Hs-IL1RN 419601 Hs-KMT2A 601731 Hs-MCAM 423001 Hs-HOPX 402041 Hs-IL2 419621 Hs-KMT2C 588851 Hs-MCL1 312341 Hs-HOTAIR 401251 Hs-IL21 595101 Hs-KRAS 451461 Hs-MCM2 422261 Hs-HOXA9-CDS 560811 Hs-IL22 444111 Hs-KRAS-No-XMm 311781 Hs-MDM2 422271 Hs-HOXA9-X-lncRNA 562851 Hs-IL23A 549681 Hs-KRT20 403711 Hs-MDM4 400781 Hs-HOXB13 406881 Hs-IL23A-sense 547901 Hs-KRT5 441841 Hs-MECP2-tv1-3UTR 583651 Hs-HPGD 554761 Hs-IL23R 550151 Hs-KRT7 419671 Hs-MED12 310341 Hs-HPRT1 406891 Hs-IL23R-sense 408081 Hs-LAPTM4B 400821 Hs-MEG3 442861 Hs-HPRT1-No-XMm 404301 Hs-IL24 440201 Hs-LCK 422281 Hs-MEIS1 419541 Hs-HRAS 542211 Hs-IL3 559441 Hs-LCN2 414421 Hs-MEN1 447341 Hs-HRAS-No-XMm 315191 Hs-IL4 412991 Hs-LEF1 431021 Hs-MET 432331 Hs-HSD11B1 416991 Hs-IL4R 406371 Hs-LEPR 423081 Hs-MET-E11-E20 432351 Hs-HSD11B2 310371 Hs-IL6 410381 Hs-LEPR-alltv 423061 Hs-MET-E2 436241 Hs-HSPA5 557201 Hs-IL6R 410371 Hs-LEPR-tv1 423091 Hs-MET-E21 560621 Hs-HTRA1 447251 Hs-IL6ST 311021 Hs-LGR5 423071 Hs-MET-E3-E10 402951 Hs-ICAM1 424251 Hs-IL7 435531 Hs-LHCGR 423101 Hs-MET-FL 414351 Hs-ID1 408841 Hs-IL7R 445721 Hs-LIF 443451 Hs-MET-no-XMm 537491 Hs-IDH1 419551 Hs-ING1 588991 Hs-LIN28A 416411 Hs-MGA 537791 Hs-IDH2 313571 Hs-INS 596361 Hs-LIN28B 588941 Hs-MGMT 602681 Hs-IDO1 406411 Hs-INSR 415941 Hs-LOX 427161 Hs-MICA 440101 Hs-IFI16 450061 Hs-INSR-O1 311341 Hs-LOXL2 427181 Hs-MICB 310501 Hs-IFN-G 419561 Hs-IRF4 483881 Hs-LPAR1 451041 Hs-MIF 417071 Hs-IFNB1 416201 Hs-IRF6 428801 Hs-LPAR2 310951 Hs-MITF 559781 Hs-IFNG 435071 Hs-ITGA2B 407421 Hs-LRIG1 591771 Hs-MKI67 310111 Hs-IGF-1R 559021 Hs-ITGA6 431121 Hs-LRP6 422971 Hs-MLH1 313031 Hs-IGF1 555091 Hs-ITGAM 421531 Hs-LRRK2 428911 Hs-MLH3 314641 Hs-IGF1-tv1 312491 Hs-ITGB6 310461 Hs-LTA 410891 Hs-MME 415811 Hs-IGF1R 605941 Hs-ITGB7 425101 Hs-LTF 412641 Hs-MMP1 450051 Hs-IGF1R-O1 546181 Hs-JAG1 426911 Hs-LYVE1 440061 Hs-MMP10 594361 Hs-IGF2 403791 Hs-JAK2 596391 Hs-MACC1 412651 Hs-MMP12 412751 Hs-IGF2BP1 420761 Hs-JUP 448651 Hs-MAF 403411 Hs-MMP13 558011 Hs-IGF2BP3 409681 Hs-KDM5B 428011 Hs-MAGEA1 408011 Hs-MMP14 313061 Hs-IGFBP2 419571 Hs-KDM5C 438761 Hs-MAGEA1-O1 311751 Hs-MMP2

4 Probe List Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 311331 Hs-MMP9 558991 Hs-NOTCH3 441541 Hs-PDGFD-No-XMm 430851 Hs-PRKAA1-O1 313811 Hs-MMP9-30LE 409631 Hs-NOTCH4 604481 Hs-PDGFRA 561721 Hs-PRKAB1 603091 Hs-MPO 412051 Hs-NOV 452051 Hs-PDGFRA-No-XMm 315811 Hs-PRL-C2 426771 Hs-MS4A1 413641 Hs-NOX4 548991 Hs-PDGFRB 542551 Hs-PRLR 414591 Hs-MSH2 419751 Hs-NPM1-X-CLEC2D 452061 Hs-PDGFRB-No-XMm 605331 Hs-PROCR 428921 Hs-MSH3 448511 Hs-NPPB 311211 Hs-PDL1 311261 Hs-PROM1 428891 Hs-MSH6 555671 Hs-NQO1 539751 Hs-PDPN 530241 Hs-PROX1 444751 Hs-MSI1 440881 Hs-NR1H3 437081 Hs-PDX1 417531 Hs-PSCA 413101 Hs-MSLN 422361 Hs-NR1I2 548451 Hs-PECAM1 405781 Hs-PTCH1 312461 Hs-MST1R 424721 Hs-NR3C1 443471 Hs-PECAM1-no-XMm 310121 Hs-PTEN 441681 Hs-MSX2 582621 Hs-NR4A2 424051 Hs-PFN1 408511 Hs-PTEN-3UTR 431321 Hs-MTAP 413021 Hs-NRAS 311771 Hs-PGF 406791 Hs-PTGER2 310631 Hs-MTNR1A 311181 Hs-NRG1 310401 Hs-PGK1 406771 Hs-PTGER4 419681 Hs-MTOR 418301 Hs-NRG1-alltv 589751 Hs-PGR 406811 Hs-PTGS1 310391 Hs-MUC1 418291 Hs-NRG1-alpha-beta1 435961 Hs-PGR-O1 406801 Hs-PTGS2 409591 Hs-MUC16 418311 Hs-NRG1-beta3 433921 Hs-PGR-tv2 537131 Hs-PTH1R 312871 Hs-MUC2 416721 Hs-NRG1-tv-alpha 419771 Hs-PHF6 404141 Hs-PTK7 312881 Hs-MUC4 424361 Hs-NRP1 603041 Hs-PIK3CA 429201 Hs-PTK7-O1 312891 Hs-MUC5AC 424371 Hs-NRP2 423891 Hs-PIK3CB 419841 Hs-PTPN11 312901 Hs-MUC6 419761 Hs-NSD1 437791 Hs-PIK3CB-O1 601991 Hs-PTPRC 424701 Hs-MXI1 437931 Hs-NT5E 520981 Hs-PIK3CD 442251 Hs-PTPRD 419691 Hs-MXRA5 449531 Hs-NTN1 590471 Hs-PIK3CG 414601 Hs-PVR 419701 Hs-MYB 402631 Hs-NTRK1 419781 Hs-PIK3R1 414611 Hs-PVR-sense 311761 Hs-MYC 406391 Hs-NTRK1-ver2 401901 Hs-PIM1 407641 Hs-PYCARD 447281 Hs-MYC-No-XMm 402621 Hs-NTRK2 425001 Hs-PLAU 416351 Hs-QKI 417501 Hs-MYCN 406341 Hs-NTRK3 542701 Hs-PLAUR 419851 Hs-RAC1 419711 Hs-MYD88 406511 Hs-OCLN 434841 Hs-PLK1 416421 Hs-RAD21 444151 Hs-MYH11 311041 Hs-OLFM4 430681 Hs-PLXNB1 559121 Hs-RAF1 416211 Hs-MYOCD 424191 Hs-OLIG2 428901 Hs-PMS2 444331 Hs-RARA 599311 Hs-NAMPT 554091 Hs-P2RX7 432551 Hs-PMS2-O1 545401 Hs-RARRES3 604491 Hs-NANOG 429811 Hs-PARP1 402431 Hs-PODXL 419861 Hs-RASA1 421461 Hs-NCAM1 588881 Hs-PAX6 419791 Hs-POLE 419871 Hs-RB1 419721 Hs-NCOR1 402361 Hs-PAX8 429901 Hs-POMC 419881 Hs-RBM10 419731 Hs-NF1 403311 Hs-PBRM1 409181 Hs-POSTN 445701 Hs-RECQL 426781 Hs-NF1-tv1tv2 312201 Hs-PCA3 419801 Hs-POU2AF1 597541 Hs-RECQL5 419741 Hs-NFE2L2 416281 Hs-PCBP1 419811 Hs-POU2F2 310551 Hs-REG1A 549451 Hs-NGF 553071 Hs-PCNA 438441 Hs-POU4F1 312071 Hs-REG4 406331 Hs-NGFR 602021 Hs-PDCD1 592861 Hs-POU5F1 417871 Hs-REST 417681 Hs-NKX2-1-ver2 316281 Hs-PDCD1-sense 445201 Hs-PPARA 424871 Hs-RET 436681 Hs-NKX3-1 406721 Hs-PDGFA 441691 Hs-PPARG 424881 Hs-RET-tv2 431311 Hs-NNMT 441061 Hs-PDGFA-No-XMm 420631 Hs-PPIA-no-X-Mm 416221 Hs-RHEB 413481 Hs-NOD2 406701 Hs-PDGFB 602231 Hs-PPM1D 416291 Hs-RHOA 416541 Hs-NODAL 441571 Hs-PDGFB-No-XMm 410251 Hs-PPP2R1A 586581 Hs-RIPK1 424991 Hs-NOS2 404281 Hs-PDGFC 419821 Hs-PPP6C 419891 Hs-RIT1 446771 Hs-NOS3 442911 Hs-PDGFC-No-XMm 401851 Hs-PRAME 432301 Hs-ROBO1 311861 Hs-NOTCH1 406711 Hs-PDGFD 419831 Hs-PRDM1 402831 Hs-ROR1

Cancer Research 5 RNAscope® Cancer Genes Probe List (continued) Probe details are available at www.acdbio.com/probesearch

Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 411091 Hs-ROR1-alltv 427981 Hs-SKIL 416371 Hs-STX2 447761 Hs-TNFRSF10A 408601 Hs-ROR2 422341 Hs-SLC19A1 403581 Hs-SULF1 412281 Hs-TNFRSF11A 316861 Hs-ROS1-E1-E11 606431 Hs-SLC29A1 422831 Hs-SYK 427131 Hs-TNFRSF11A-O1 314751 Hs-ROS1-E1-E30 423141 Hs-SLC2A1 423501 Hs-T 412291 Hs-TNFRSF11B 314321 Hs-ROS1-E30-E43 315831 Hs-SLC39A6-E2 551641 Hs-TACC3 430601 Hs-TNFRSF11B-O1 316871 HS-ROS1-E35-E43 429341 Hs-SLC4A5 310701 Hs-TACR1 406961 Hs-TNFRSF13C 416361 Hs-RPL5 604741 Hs-SLC6A4 405471 Hs-TACSTD2 319731 Hs-TNFRSF14 310411 Hs-RRM1 404231 Hs-SMAD2 498961 Hs-TAGLN 319721 Hs-TNFRSF14-sense 415911 Hs-RRM2 404241 Hs-SMAD3 416441 Hs-TAP1 400611 Hs-TNFRSF1A 445631 Hs-RRM2-No-XMm 404251 Hs-SMAD4 601121 Hs-TBK1 417651 Hs-TNFRSF1B 402211 Hs-RTN4 419141 Hs-SMAD7 420021 Hs-TBL1XR1 429831 Hs-TNFRSF6B 419901 Hs-RUNX1 419931 Hs-SMARCA4 444731 Hs-TBX3 593451 Hs-TNFRSF8 440071 Hs-RUNX2 419941 Hs-SMARCB1 420031 Hs-TCEB1 415171 Hs-TNFRSF9 416431 Hs-RXRA 521561 Hs-SMC1A 420041 Hs-TCF7L2 411841 Hs-TNFSF10 400861 Hs-S100A11 419951 Hs-SMC3 414801 Hs-TEK 431641 Hs-TNFSF10-O1 422071 Hs-S100A4 405831 Hs-SMO 312361 Hs-TERC 412271 Hs-TNFSF11 433241 Hs-S100A6 560421 Hs-SNAI1 605511 Hs-TERT 430591 Hs-TNFSF11-O1 425271 Hs-S100A8 554581 Hs-SNAI2 420051 Hs-TET2 440891 Hs-TNFSF12 417581 Hs-S100A9 605681 Hs-SNCA 427761 Hs-TFE3-E4-E10 406981 Hs-TNFSF13 430891 Hs-S100B 409021 Hs-SNCA-CDS 430461 Hs-TFE3-E4-E10-O1 406971 Hs-TNFSF13B 401931 Hs-S100P 421311 Hs-SNCA-ver2 435281 Hs-TFE3-E4-E10-O2 403121 Hs-TNFSF15 313421 Hs-SAT1 410501 Hs-SNCG 417281 Hs-TFF1 605201 Hs-TP53 410431 Hs-SCGB2A2 427311 Hs-SOD1 407431 Hs-TFF2 416241 Hs-TP53BP1 430281 Hs-SCN5A 410061 Hs-SOD1-noXMm 403101 Hs-TFF3 601891 Hs-TP63 416961 Hs-SDC1 408411 Hs-SOS1 437341 Hs-TFR2-XMfa 405481 Hs-TPBG 432181 Hs-SDC2 419961 Hs-SOX17 437351 Hs-TFRC-XMfa 403931 Hs-TPBG-O1 440361 Hs-SELE 400871 Hs-SOX2 313131 Hs-TGFA 434351 Hs-TPD52 435081 Hs-SELP 404221 Hs-SOX9 400881 Hs-TGFB1 416311 Hs-TPX2 416561 Hs-SEMA3A 431031 Hs-SOX9-O1 407121 Hs-TGFB1-long 420061 Hs-TRAF3 432201 Hs-SEMA3F 425111 Hs-SPARC 443481 Hs-TGFB1-no-XMm 495221 Hs-TRIM23 435441 Hs-SERPINA1 419971 Hs-SPEN 404581 Hs-TGFB2 412471 Hs-TRPC6 412671 Hs-SERPINA3 416041 Hs-SPHK1 431041 Hs-TGFBR1 439211 Hs-TRPS1 401941 Hs-SERPINB5 422931 Hs-SPINT1 407941 Hs-TGFBR2 415381 Hs-TRPV1 555961 Hs-SERPINE1 419981 Hs-SPOP 441031 Hs-TGFBR3 420071 Hs-TSC1 310561 Hs-SERT 420101 Hs-SPP1 439761 Hs-THPO 312731 Hs-TSC2 419911 Hs-SETD2 405321 Hs-SPRY2 430611 Hs-THY1 403541 Hs-TSLP 416231 Hs-SETDB1 415881 Hs-SQSTM1 433101 Hs-TIMP3 438021 Hs-TSPO 419921 Hs-SF3B1 445601 Hs-SQSTM1-No-XMm 440381 Hs-TJP1 402841 Hs-TSPY1 429381 Hs-SFRP1 310571 Hs-SSTR2 446261 Hs-TK1 445131 Hs-TTK 313351 Hs-SFRP4 312861 Hs-SSTR5 403111 Hs-TLR2 588791 Hs-TUBB 416301 Hs-SGK1 422911 Hs-ST14 605951 Hs-TLR3 318901 Hs-TUBB3 431861 Hs-SHC1 498361 Hs-ST8SIA1 311281 Hs-TLR4 310431 Hs-TWIST 600951 Hs-SHH 420001 Hs-STAG2 541441 Hs-TLR7 602381 Hs-TXNIP 430331 Hs-SIRPA 425631 Hs-STAT3 420771 Hs-TNC 446271 Hs-TYMP 429781 Hs-SIRT1 413011 Hs-STK11 310421 Hs-TNF-a 415871 Hs-TYMS 412401 Hs-SIX1 420011 Hs-STK19 426481 Hs-TNFAIP3 446201 Hs-TYMS-CDS

6 Probe List Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 420081 Hs-U2AF1 412011 Hs-VEGFA-noXrodent 429431 Hs-WNT3A 431591 Hs-YAP1-tv2-CDS 402241 Hs-UBB 450611 Hs-VEGFC-No-XMm 604921 Hs-WNT5A 313191 Hs-ZEB1 407341 Hs-UBB-sense 312121 Hs-VEGFR2 445711 Hs-WRN 404271 Hs-ZEB2 410971 Hs-UBC-sense 401951 Hs-VHL 415581 Hs-WT1 420091 Hs-ZFHX3 594281 Hs-UCHL1 310441 Hs-VIM 421351 Hs-WWTR1 427351 Hs-ZFP36 446281 Hs-UMPS 418081 Hs-VTCN1 427771 Hs-WWTR1-tv1-E1E2 416381 Hs-ZNF750 440371 Hs-VCAM1 440901 Hs-VTN 412481 Hs-XAGE1B 416451 Hs-ZRANB3 430071 Hs-VCAN 560461 Hs-VWF 436251 Hs-XBP1 310971 S100B 452231 Hs-VCAN-E7 451521 Hs-VWF-No-XMm 427211 Hs-XIAP 310711 TAC1 452241 Hs-VCAN-E8 429391 Hs-WIF1 415101 Hs-XPO1 311351 Hs-VEGF 429421 Hs-WNT1 419131 Hs-YAP1 423161 Hs-VEGFA 584071 Hs-WNT2 427751 Hs-YAP1-E1

RNAscope® Probes available for Breast Cancer Related Genes

ABCB1 BCL2 CDH1 CTNNB1 GATA3 IGFBP3 MAPK3 MYC PTGS2 SLC39A6 TP73 ABCG2 BIRC5 CDH13 CTSD GLI1 IL6 MAPK8 NME1 PYCARD SLIT2 TWIST1 ADAM23 BRCA1 CDK2 EGF GRB7 JUN MGMT NOTCH1 RARB SNAI2 VEGFA AKT1 BRCA2 CDKN1A EGFR GSTP1 KRT18 MKI67 NR3C1 RASSF1 SRC XBP1 APC CCNA1 CDKN1C ERBB2 HIC1 KRT19 MLH1 PGR RB1 TFF3 AR CCND1 CDKN2A ESR1 ID1 KRT5 MMP2 PLAU SERPINE1 TGFB1 ATM CCND2 CSF1 ESR2 IGF1 KRT8 MMP9 PRDM2 SFN THBS1 BAD CCNE1 CST6 FOXA1 IGF1R MAPK1 MUC1 PTEN SFRP1 TP53

RNAscope® Probes available for Lung Cancer Related Genes

AGER BRAF CEACAM5 CXCL12 ERBB3 IRF4 MKI67 NFKB1 RB1 SPRR1A TOX3 AGR2 CA4 CEACAM6 CXCL13 FABP4 KRAS MLH1 NKX2-1 SCGB1A1 STAT1 TP53 AKT1 CADM1 CLCA2 CYP1B1 FHIT KRT14 MMD OPCML SFRP1 STAT2 VEGFA ANXA5 CDH1 CLDN18 DLC1 GPM6A KRT5 MMP1 PAX5 SFTA3 TCF21 WIF1 APBA1 CDH13 CLIC5 DSG3 GREM1 LCK MMP12 PRDM2 SFTPC TERT APC CDKN1C COL11A1 DUSP6 HGF LGSN MMP9 PTGS2 SOSTDC1 TGFB1 BCL2 CDKN2A CP EGFR HMMR MET MTHFR RASSF1 SPINK1 TNF BIRC5 CDKN2B CSF3 ERBB2 HRAS MGMT NF1 RASSF2 SPP1 TOP2A

RNAscope® Probes available for Prostate Cancer Related Genes

ACACA CASP3 CLN3 EGFR GSTP1 LGALS4 NDRG3 PRKAB1 SEPT7 TFPI2 AKT1 CAV1 CREB1 EGR3 HAL LOXL1 NFKB1 PTEN SFRP1 TIMP2 APC CAV2 DAXX ERG HMGCR MAPK1 NKX3-1 PTGS1 SLC5A8 TIMP3 AR CCNA1 * ETV1 IGF1 MAX NRIP1 PTGS2 SOCS3 TMPRSS2 ARNTL CCND1 DKK3 FASN IGFBP5 MGMT PDLIM4 RARB SOX4 TNFRSF10D BCL2 CCND2 DLC1 FOXO1 IL6 MKI67 PDPK1 RASSF1 SREBF1 TP53 CAMKK1 CDH1 ECT2 GNRH1 KLHL13 MSX1 PES1 RBM39 STK11 VEGFA CAMSAP1 CDKN2A EDNRB GPX3 KLK3 MTO1 PPP2R1B SCAF11 SUPT7L ZNF185

*No RNAscope® probe was designed for DDX11 gene, due to very high homology with DDX12P.

Cancer Research 7 RNAscope® Probes available for Human Papillomavirus Genes

Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name Catalog No. Probe Name 421581 HPV5 421651 HPV19 407531 HPV43 407581 HPV71 407501 HPV6 421661 HPV20 407541 HPV44 311681 HPV73 415211 HPV6/11 421671 HPV21 311591 HPV45 407591 HPV74 421591 HPV8 421681 HPV22 421751 HPV47 421771 HPV75 421601 HPV9 421691 HPV23 421761 HPV49 421781 HPV76 316431 HPV10-E6 421701 HPV24 311601 HPV51 421791 HPV80 319951 HPV10-E6E7 421711 HPV25 311611 HPV52 311691 HPV82 311471 HPV11 311541 HPV26 311621 HPV53 421801 HPV92 421611 HPV12 311551 HPV31 407551 HPV54 421811 HPV93 421621 HPV14 311561 HPV33 311631 HPV56 421821 HPV96 421631 HPV15 311571 HPV35 311641 HPV58 312591 HPV-HR18 311521 HPV16 421721 HPV36 311651 HPV59 312351 HPV-HR7 311121 HPV16/18 421731 HPV37 311661 HPV66 314551 HPVLR10 315571 HPV16-E2 421741 HPV38 404091 HPV67-E6E7 407601 HPVLR6 315601 HPV16-L1 311581 HPV39 311671 HPV68 421641 HPV17 407511 HPV40 407561 HPV69 311531 HPV18 407521 HPV42 407571 HPV70

ACD offers an ever-growing selection of RNA ISH probes. Don’t see your gene of interest? RNAscope® Made-to-Order Target Probes and manufactured within 2 weeks for virtually ANY gene from ANY species in ANY tissue. Learn more at www.acdbio.com/target-probes-made-order

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For Research Use Only. Not for diagnostic use. RNAscope is a registered trademark of Advanced Cell Diagnostics, Inc. in the United States or other countries. All rights reserved. California, USA ©2016 Advanced Cell Diagnostics, Inc. Doc #: MK 51-013/Rev A/Effective date 04152016